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Background/Aim. The gold standard in treating the advanced ovarian cancer (AOC) is primary debulking surgery (PDS) followed by platinum-based adjuvant chemotherapy. In the AOC, the extent of tumor resection (residual tumor volume) is the most important prognostic factor for overall survival (OS) and progression-free survival (PFS). Neoadjuvant chemotherapy (NACT) followed by interval debulking surgery (IDS) is an experimental treatment of the AOC, introduced in clinical practice in order to improve cytoreduction rate and prolong survival. The aim of this study was to compare the survival and cytoreduction rate of NACT+IDS and PDS in patients with the AOC. Methods. This retrospective cohort study included patients with the AOC, separated into two groups. The first group treated with PDS had 59 patients, while the second group, treated with NACT + IDS, had 33 patients. Results. A lower rate of suboptimal cytoreduction (39.39%) was found in the NACT + IDS group than in the PDS group (57.63%). The percentage of complete cytoreduction was higher in patients treated with NACT + IDS (51.52%) than in those treated with PDS (38.98%). Nevertheless, median OS and PFS were not significantly different between the groups (p < 0.05). OS was 35 months and 31 months in the PDS and NACT + IDS groups, respectively. PFS was 16 months in the PDS and 19 months in the NACT + IDS group. Conclusion. Despite the higher rate of optimal debulking surgery after NACT+ IDS, survival of patients treated with method was not better than those treated with PDS. The decision for either NACT+IDS or PDS should be tailored to the individual patient.

Introduction/Background Endometrial cancer is the most common malignancy of the female reproductive tract. Lymph node metastases are an important prognostic factor in endometrial cancer. Several prognostic factors have been shown to correlate with lymph node metastasis: depth of myometrial invasion, cervical infiltration, histologic grade of the tumor, tumor diameter, serous histology, lymphovascular invasion, and positive peritoneal cytology. Methodology Finding the pathohistological parameters that will indicate with greater certainty the possibility of metastases in the lymph nodes, on the basis of which it will be evaluated whether such patients should undergo lymphadenectomy or not. A retrospective analysis of patients with endometrial cancer who underwent surgery at the Oncology Institute of Vojvodina (Clinic for Operative Oncology – Department of Gynecology) in the period from 2012 to 2018.The study included 120 patients who underwent hysterectomy with bilateral adnexectomy and pelvic lymphadenectomy. Results Among patients who had lymph node metastases, there were statistically significant more patients (p Conclusion Histopathological parameters such as type 2 endometrial cancer, myometrial invasion depth greater than 50%, cervical stroma infiltration, lymphovascular invasion and positive peritoneal cytology increase the chances of lymph node metastases. Tumor size (> 2 cm) as well as histologic grade did not correlate with a higher incidence of lymph node metastases. In this study, both the parametrial infiltration and the number of lymph nodes removed have clinical significance, but not statistical significance.