44 results on '"Dunford, Paul J."'
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2. Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study
3. The Role of Histamine in Asthma
4. Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo
5. The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis
6. Histamine H 4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus
7. Histamine H4 receptor antagonists
8. The CSF-1-receptor inhibitor, JNJ-40346527 (PRV-6527), reduced inflammatory macrophage recruitment to the intestinal mucosa and suppressed murine T cell mediated colitis
9. Leukotriene A4 Hydrolase Inhibition Attenuates Allergic Airway Inflammation and Hyperresponsiveness
10. The Histamine H4 Receptor: Drug Discovery in the Post-genomic Era
11. The histamine H4 receptor: A novel modulator of inflammatory and immune disorders
12. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus
13. Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat
14. Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines
15. Toreforant, an orally active histamine H4-receptor antagonist, in patients with active rheumatoid arthritis despite methotrexate: mechanism of action results from a phase 2, multicenter, randomized, double-blind, placebo-controlled synovial biopsy study
16. The Histamine H4 Receptor Antagonist, JNJ 39758979, Is Effective in Reducing Histamine-Induced Pruritus in a Randomized Clinical Study in Healthy Subjects
17. Discovery and SAR of 6-Alkyl-2,4-diaminopyrimidines as Histamine H4 Receptor Antagonists
18. Clinical and Preclinical Characterization of the Histamine H4 Receptor Antagonist JNJ-39758979
19. The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis
20. Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines
21. The Histamine H4 Receptor Mediates Inflammation and Pruritus in Th2-Dependent Dermal Inflammation
22. Identification of a Potent, Selective, and Orally Active Leukotriene A4 Hydrolase Inhibitor with Anti-Inflammatory Activity
23. Histamine 4 Receptor Antagonism modulates TH2 cell function, IL13 production, and lung remodeling in a model of chronic asthma
24. A novel B-RAF inhibitor blocks interleukin-8 (IL-8) synthesis in human melanoma xenografts, revealing IL-8 as a potential pharmacodynamic biomarker
25. Measurement and Inhibition of Airway Hyperreactivity in a Guinea Pig Model of Allergic Asthma
26. Leukotriene A 4 Hydrolase Inhibitors Decrease Allergic Airway Inflammation and Hyperreactivity by Modulating Leukocyte Recruitment and IL‐13 Production
27. The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines
28. A cross-sectional study of the prevalence of neck pain, decreased cervical range of motion and head repositioning accuracy in forwards and backs in rugby union
29. The Histamine H4 Receptor (H4R) Mediates Inflammatory Responses in a Th2-dependent, FITC-induced Atopic Dermatitis Model (B199)
30. Anti-Inflammatory Activity of a Potent, Selective Leukotriene A4 Hydrolase Inhibitor in Comparison with the 5-Lipoxygenase Inhibitor Zileuton
31. The Histamine H4 Receptor Mediates Allergic Airway Inflammation by Regulating the Activation of CD4+ T Cells
32. Preparation and Biological Evaluation of Indole, Benzimidazole, and Thienopyrrole Piperazine Carboxamides: Potent Human Histamine H4Antagonists
33. A Potent and Selective Histamine H4 Receptor Antagonist with Anti-Inflammatory Properties
34. Rapid Up-Regulation of CXC Chemokines in the Airways after Ag-Specific CD4+ T Cell Activation
35. Discovery and SAR of 6-Alkyl-2,4-diaminopyrimidinesas Histamine H4Receptor Antagonists.
36. The histamine H4 receptor mediates inflammation and Th17 responses in preclinical models of arthritis.
37. Histamine H4 receptor antagonists.
38. Histamine H4 receptor antagonism diminishesexisting airway inflammation and dysfunction viamodulation of Th2 cytokines.
39. Pharmacological characterization of oxime agonists of the histamine H4 receptor.
40. The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines.
41. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus.
42. The Histamine H4 Receptor Mediates Inflammation and Pruritus in Th2-Dependent Dermal Inflammation.
43. The histamine H4 receptor: A novel modulator of inflammatory and immune disorders
44. Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat
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