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186 results on '"Duncker, Dirk-jan"'

1. Comparison of Large Animal Models for Acute Ischemic Stroke:Which Model to Use?

Author

Taha, Aladdin, Bobi, Joaquim, Dammers, R., Dijkhuizen, Rick M., Dreyer, Antje Y., Van Es, Adriaan C.G.M., Ferrara, Fabienne, Gounis, Matthew, Nitzsche, Björn, Platt, Simon, Stoffel, Michael H., Volovici, Victor, Del Zoppo, Gregory J., Duncker, Dirk-jan, Dippel, Diederik, Boltze, Johannes, van Beusekom, H.M.M., Taha, Aladdin, Bobi, Joaquim, Dammers, R., Dijkhuizen, Rick M., Dreyer, Antje Y., Van Es, Adriaan C.G.M., Ferrara, Fabienne, Gounis, Matthew, Nitzsche, Björn, Platt, Simon, Stoffel, Michael H., Volovici, Victor, Del Zoppo, Gregory J., Duncker, Dirk-jan, Dippel, Diederik, Boltze, Johannes, and van Beusekom, H.M.M.

Abstract

Translation of acute ischemic stroke research to the clinical setting remains limited over the last few decades with only one drug, recombinant tissue-type plasminogen activator, successfully completing the path from experimental study to clinical practice. To improve the selection of experimental treatments before testing in clinical studies, the use of large gyrencephalic animal models of acute ischemic stroke has been recommended. Currently, these models include, among others, dogs, swine, sheep, and nonhuman primates that closely emulate aspects of the human setting of brain ischemia and reperfusion. Species-specific characteristics, such as the cerebrovascular architecture or pathophysiology of thrombotic/ischemic processes, significantly influence the suitability of a model to address specific research questions. In this article, we review key characteristics of the main large animal models used in translational studies of acute ischemic stroke, regarding (1) anatomy and physiology of the cerebral vasculature, including brain morphology, coagulation characteristics, and immune function; (2) ischemic stroke modeling, including vessel occlusion approaches, reproducibility of infarct size, procedural complications, and functional outcome assessment; and (3) implementation aspects, including ethics, logistics, and costs. This review specifically aims to facilitate the selection of the appropriate large animal model for studies on acute ischemic stroke, based on specific research questions and large animal model characteristics.

Published
2022

3. Towards standardization of echocardiography for the evaluation of left ventricular function in adult rodents: a position paper of the ESC Working Group on Myocardial Function

Author

Zacchigna, S, Paldino, A, Falcao-Pires, I, Daskalopoulos, EP, Dal Ferro, M, Vodret, S, Lesizza, P, Cannata, A, Miranda-Silva, D, Lourenco, A P, Pinamonti, B, Sinagra, G, Weinberger, F, Eschenhagen, T, Carrier, L, Kehat, I, Tocchetti, CG, Russo, M, Ghigo, A, Cimino, J, Hirsch, E, Dawson, D, Ciccarelli, M, Oliveti, M, Linke, WA, Cuijpers, I, Heymans, S, Hamdani, N, Boer, Monique, Duncker, Dirk-jan, Kuster, D, Velden, J, Beauloye, C, Bertrand, L, Mayr, M, Giacca, M, Leuschner, F, Backs, J, Thum, T, Zacchigna, S, Paldino, A, Falcao-Pires, I, Daskalopoulos, EP, Dal Ferro, M, Vodret, S, Lesizza, P, Cannata, A, Miranda-Silva, D, Lourenco, A P, Pinamonti, B, Sinagra, G, Weinberger, F, Eschenhagen, T, Carrier, L, Kehat, I, Tocchetti, CG, Russo, M, Ghigo, A, Cimino, J, Hirsch, E, Dawson, D, Ciccarelli, M, Oliveti, M, Linke, WA, Cuijpers, I, Heymans, S, Hamdani, N, Boer, Monique, Duncker, Dirk-jan, Kuster, D, Velden, J, Beauloye, C, Bertrand, L, Mayr, M, Giacca, M, Leuschner, F, Backs, J, and Thum, T

Abstract

Echocardiography is a reliable and reproducible method to assess non-invasively cardiac function in clinical and experimental research. Significant progress in the development of echocardiographic equipment and transducers has led to the successful translation of this methodology from humans to rodents, allowing for the scoring of disease severity and progression, testing of new drugs, and monitoring cardiac function in genetically modified or pharmacologically treated animals. However, as yet, there is no standardization in the procedure to acquire echocardiographic measurements in small animals. This position paper focuses on the appropriate acquisition and analysis of echocardiographic parameters in adult mice and rats, and provides reference values, representative images, and videos for the accurate and reproducible quantification of left ventricular function in healthy and pathological conditions.

Published
2021

4. The relation between pre-existing plaque burden and strut coverage after DES implantation in familial hypercholesterolemia swine: an OCT study

Author

Razzi, Francesca, primary, Dijkstra, Jouke, additional, Witberg, Karen, additional, Ligthart, Jurgen, additional, Ramlal, Sharad, additional, Stam, Mathijs, additional, Krabbendam-Peters, Ilona, additional, Hoogendoorn, Ayla, additional, Duncker, Dirk-Jan, additional, van Esch, Jan, additional, Wentzel, Jolanda, additional, van Soest, Gijs, additional, van Steijn, Volkert, additional, Regar, Evelyn, additional, and van Beusekom, Heleen, additional

Published
2021
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5. Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases in Extracellular Matrix Remodeling during Left Ventricular Diastolic Dysfunction and Heart Failure with Preserved Ejection Fraction: A Systematic Review and Meta-Analysis

Author

Krebber, M M, van Dijk, CGM, Vernooij, RWM, Brandt, Maarten, Emter, CA, Rau, CD, Fledderus, J O, Duncker, Dirk-jan, Verhaar, MC, Cheng, CE, Joles, JA, Krebber, M M, van Dijk, CGM, Vernooij, RWM, Brandt, Maarten, Emter, CA, Rau, CD, Fledderus, J O, Duncker, Dirk-jan, Verhaar, MC, Cheng, CE, and Joles, JA

Published
2020

6. Cellular, mitochondrial and molecular alterations associate with early left ventricular diastolic dysfunction in a porcine model of diabetic metabolic derangement

Author

Heinonen, Ilkka, Sorop, Oana, van Dalen, Bas, Wüst, RCI, van de Wouw, Jens, Beer, Vincent, Octavia, Yanti, Duin, Richard, Hoogstrate, Youri, Blonden, Lau, Alkio, M, Anttila, K, Stubbs, Andrew, Velden, J, Merkus, Daphne, Duncker, Dirk-jan, Heinonen, Ilkka, Sorop, Oana, van Dalen, Bas, Wüst, RCI, van de Wouw, Jens, Beer, Vincent, Octavia, Yanti, Duin, Richard, Hoogstrate, Youri, Blonden, Lau, Alkio, M, Anttila, K, Stubbs, Andrew, Velden, J, Merkus, Daphne, and Duncker, Dirk-jan

Published
2020

7. H3K27ac acetylome signatures reveal the epigenomic reorganization in remodeled non-failing human hearts

Author

Pei, JY, Harakalova, M, Treibel, TA, Lumbers, RT, Boukens, BJ, Efimov, IR, van Dinter, JT, Gonzalez, A, Lopez, B, el Azzouzi, H, van den Dungen, N, van Dijk, CGM, Krebber, M M, den Ruijter, HM, Pasterkamp, G, Duncker, Dirk-jan, Nieuwenhuis, EES, de Weger, R, Huibers, MMH, Vink, A, Moore, JH, Moon, JC, Verhaar, MC, Kararigas, G, Mokry, M, Asselbergs, FW, Cheng, Caroline, Pei, JY, Harakalova, M, Treibel, TA, Lumbers, RT, Boukens, BJ, Efimov, IR, van Dinter, JT, Gonzalez, A, Lopez, B, el Azzouzi, H, van den Dungen, N, van Dijk, CGM, Krebber, M M, den Ruijter, HM, Pasterkamp, G, Duncker, Dirk-jan, Nieuwenhuis, EES, de Weger, R, Huibers, MMH, Vink, A, Moore, JH, Moon, JC, Verhaar, MC, Kararigas, G, Mokry, M, Asselbergs, FW, and Cheng, Caroline

Published
2020

9. A new microfluidic model that allows monitoring of complex vascular structures and cell interactions in a 3D biological matrix

Author

van Dijk, CGM, Brandt, Maarten, Poulis, N, Anten, J, van der Moolen, M, Kramer, L, Homburg, E, Louzao-Martinez, L, Pei, JY, Krebber, M M, van Balkom, BWM, de Graaf, P, Duncker, Dirk-jan, Verhaar, MC, Luttge, R, Cheng, Caroline, van Dijk, CGM, Brandt, Maarten, Poulis, N, Anten, J, van der Moolen, M, Kramer, L, Homburg, E, Louzao-Martinez, L, Pei, JY, Krebber, M M, van Balkom, BWM, de Graaf, P, Duncker, Dirk-jan, Verhaar, MC, Luttge, R, and Cheng, Caroline

Published
2020

11. Lentiviral Hematopoietic Stem Cell Gene Therapy Corrects Murine Pompe Disease

Author

Stok, Merel, Boer, Helen, Huston, MW, Jacobs, EH, Roovers, Onno, Visser, Trui, Jahr, Holger, Duncker, Dirk-jan, Deel, Elza, Reuser, Arnold, Til, Niek, Wagemaker, Gerard, Stok, Merel, Boer, Helen, Huston, MW, Jacobs, EH, Roovers, Onno, Visser, Trui, Jahr, Holger, Duncker, Dirk-jan, Deel, Elza, Reuser, Arnold, Til, Niek, and Wagemaker, Gerard

Published
2020

12. Both male and female obese ZSF1 rats develop cardiac dysfunction in obesity-induced heart failure with preserved ejection fraction

Author

Nguyen, ITN, Brandt, Maarten, van de Wouw, Jens, van Drie, Ruben, Wesseling, M, Cramer, MJM, de Jager, SCA, Merkus, Daphne, Duncker, Dirk-jan, Cheng, Caroline, Joles, JA, Verhaar, MC, Nguyen, ITN, Brandt, Maarten, van de Wouw, Jens, van Drie, Ruben, Wesseling, M, Cramer, MJM, de Jager, SCA, Merkus, Daphne, Duncker, Dirk-jan, Cheng, Caroline, Joles, JA, and Verhaar, MC

Published
2020

14. Multidirectional wall shear stress promotes advanced coronary plaque development: comparing five shear stress metrics

Author

Hoogendoorn, Ayla, Kok, Annette, Hartman, Eline, De Nisco, G, Casadonte, L, Chiastra, C, Coenen, Adriaan, Korteland, SA (Suze-Anne), van der Heiden, Kim, Gijsen, Frank, Duncker, Dirk-jan, van der Steen, Ton, Wentzel, Jolanda, Hoogendoorn, Ayla, Kok, Annette, Hartman, Eline, De Nisco, G, Casadonte, L, Chiastra, C, Coenen, Adriaan, Korteland, SA (Suze-Anne), van der Heiden, Kim, Gijsen, Frank, Duncker, Dirk-jan, van der Steen, Ton, and Wentzel, Jolanda

Published
2020

16. Lower Plasma Melatonin Levels Predict Worse Long-Term Survival in Pulmonary Arterial Hypertension

Author

Cai, Zongye, Klein, Theo, Geenen, Laurie, Tu, L, Tian, Siyu, Bosch, Annemien, Rijke, Yolanda, Reiss, Irwin, Boersma, Eric, Duncker, Dirk-jan, Boomars, Karin, Guignabert, C, Merkus, Daphne, Cai, Zongye, Klein, Theo, Geenen, Laurie, Tu, L, Tian, Siyu, Bosch, Annemien, Rijke, Yolanda, Reiss, Irwin, Boersma, Eric, Duncker, Dirk-jan, Boomars, Karin, Guignabert, C, and Merkus, Daphne

Published
2020

19. A direct comparison of natural and acoustic-radiation-force-induced cardiac mechanical waves

Author

Keijzer, Lana, Caenen, Annette, Voorneveld, Jason, Strachinaru, Mihai, Bowen, Daniel, van de Wouw, Jens, Sorop, Oana, Merkus, Daphne, Duncker, Dirk-jan, van der Steen, Ton, Jong, Nico, Bosch, Hans, Vos, Rik, Keijzer, Lana, Caenen, Annette, Voorneveld, Jason, Strachinaru, Mihai, Bowen, Daniel, van de Wouw, Jens, Sorop, Oana, Merkus, Daphne, Duncker, Dirk-jan, van der Steen, Ton, Jong, Nico, Bosch, Hans, and Vos, Rik

Published
2020

23. Vascular remodelling

Author

Gielen, S, Laughlin, MH, Duncker, Dirk-jan, and Cardiology

Published
2019

25. A proteome comparison between human fetal and mature renal extracellular matrix identifies EMILIN1 as a regulator of renal epithelial cell adhesion

Author

Louzau-Martinez, L, van Dijk, CGM, Xu, YJ (Yan Juan), Korn, A, Bekker, NJ, Brouwhuis, R, Novella Nicese, M, Demmers, Jeroen, Goumans, MJ, Masereeuw, R, Duncker, Dirk-jan, Verhaar, MC, Cheng, Caroline, Louzau-Martinez, L, van Dijk, CGM, Xu, YJ (Yan Juan), Korn, A, Bekker, NJ, Brouwhuis, R, Novella Nicese, M, Demmers, Jeroen, Goumans, MJ, Masereeuw, R, Duncker, Dirk-jan, Verhaar, MC, and Cheng, Caroline

Published
2019

29. Variation in Coronary Atherosclerosis Severity Related to a Distinct LDL (Low-Density Lipoprotein) Profile Findings From a Familial Hypercholesterolemia Pig Model

Author

Hoogendoorn, Ayla, den Hoedt, Sandra, Hartman, Eline, Peters, Ilona, Lintel Hekkert, Maaike, Van der Zee - van Vark, Leonie, van Gaalen, Kim, Witberg, Karen, Dorst - Lagerwerf, Kristien, Ligthart, Jurgen, Drouet, L, van der Heiden, Kim, Roeters van Lennep, Jeanine, van der Steen, Ton, Duncker, Dirk-jan, Mulder, Monique, Wentzel, Jolanda, Hoogendoorn, Ayla, den Hoedt, Sandra, Hartman, Eline, Peters, Ilona, Lintel Hekkert, Maaike, Van der Zee - van Vark, Leonie, van Gaalen, Kim, Witberg, Karen, Dorst - Lagerwerf, Kristien, Ligthart, Jurgen, Drouet, L, van der Heiden, Kim, Roeters van Lennep, Jeanine, van der Steen, Ton, Duncker, Dirk-jan, Mulder, Monique, and Wentzel, Jolanda

Published
2019

38. Endothelial loss of Fzd5 stimulates PKC/Ets1-mediated transcription of Angpt2 and Flt1

Author

Brandt, Maarten, van Dijk, CGM, Chrifi, Ihsane, Kool, Heleen, Bürgisser, Petra, Louzao-Martinez, L, Pei, JY, Rottier, Robbert, Verhaar, MC, Duncker, Dirk-jan, Cheng, Caroline, Brandt, Maarten, van Dijk, CGM, Chrifi, Ihsane, Kool, Heleen, Bürgisser, Petra, Louzao-Martinez, L, Pei, JY, Rottier, Robbert, Verhaar, MC, Duncker, Dirk-jan, and Cheng, Caroline

Published
2018

41. Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening

Author

Sorop, Oana, Heinonen, Ilkka, Kranenburg, Matthijs, van de Wouw, Jens, Beer, Vincent, Nguyen, Isabel. TN, Octavia, Yanti, Duin, Richard, Stam, Kelly, van Geuns, Robert Jan, Wielopolski, Piotr, Krestin, Gabriel, van den Meiracker, Ton, Verjans, R, van Bilsen, M, Danser, AHJ, Paulus, WJ, Cheng, Caroline, Linke, WA, Joles, JA, Verhaar, MC, Velden, J, Merkus, Daphne, Duncker, Dirk-jan, Sorop, Oana, Heinonen, Ilkka, Kranenburg, Matthijs, van de Wouw, Jens, Beer, Vincent, Nguyen, Isabel. TN, Octavia, Yanti, Duin, Richard, Stam, Kelly, van Geuns, Robert Jan, Wielopolski, Piotr, Krestin, Gabriel, van den Meiracker, Ton, Verjans, R, van Bilsen, M, Danser, AHJ, Paulus, WJ, Cheng, Caroline, Linke, WA, Joles, JA, Verhaar, MC, Velden, J, Merkus, Daphne, and Duncker, Dirk-jan

Abstract

Aims: More than 50% of patients with heart failure have preserved ejection fraction characterized by diastolic dysfunction. The prevalance of diastolic dysfunction is higher in females and associates with multiple comorbidities such as hypertension (HT), obesity, hypercholesterolemia (HC), and diabetes mellitus (DM). Although its pathophysiology remains incompletely understood, it has been proposed that these comorbidities induce systemic inflammation, coronary microvascular dysfunction, and oxidative stress, leading to myocardial fibrosis, myocyte stiffening and, ultimately, diastolic dysfunction. Here, we tested this hypothesis in a swine model chronically exposed to three common comorbidities. Methods and results: DM (induced by streptozotocin), HC (produced by high fat diet), and HT (resulting from renal artery embolization), were produced in 10 female swine, which were followed for 6 months. Eight female healthy swine on normal pig-chow served as controls. The DM + HC + HT group showed hyperglycemia, HC, hypertriglyceridemia, renal dysfunction and HT, which were associated with systemic inflammation. Myocardial superoxide production was markedly increased, due to increased NOX activity and eNOS uncoupling, and associated with reduced NO production, and impaired coronary small artery endothelium-dependent vasodilation. These abnormalities were accompanied by increased myocardial collagen content, reduced capillary/fiber ratio, and elevated passive cardiomyocyte stiffness, resulting in an increased left ventricular end-diastolic stiffness (measured by pressure–volume catheter) and a trend towards a reduced E/A ratio (measured by cardiac MRI), while ejection fraction was maintained. Conclusions: The combination of three common comorbidities leads to systemic inflammation, myocardial oxidative stress, and coronary microvascular dysfunction, which associate with myocardial stiffening and LV diastolic dysfunction with pres

Published
2018

44. The effect of bioresorbable vascular scaffold implantation on distal coronary endothelial function in dyslipidemic swine with and without diabetes

Author

Heuvel, Mieke, Sorop, Oana, Ditzhuijzen, Nienke, de Vries, René, Duin, Richard, Peters, Ilona, Loon, Janine, de Maat, Moniek, van Beusekom, H.M.M., Giessen, Wim, Danser, AHJ, Duncker, Dirk-jan, Heuvel, Mieke, Sorop, Oana, Ditzhuijzen, Nienke, de Vries, René, Duin, Richard, Peters, Ilona, Loon, Janine, de Maat, Moniek, van Beusekom, H.M.M., Giessen, Wim, Danser, AHJ, and Duncker, Dirk-jan

Abstract

Background: We studied the effect of bioresorbable vascular scaffold (BVS) implantation on distal coronary endothelial function, in swine on a high fat diet without (HFD) or with diabetes (DM + HFD). Methods: Five DM + HFD and five HFD swine underwent BVS implantation on top of coronary plaques, and were studied six months later. Conduit artery segments >5 mm proximal and distal to the scaffold and corresponding segments of non-scaffolded coronary arteries, and segments of small arteries within the flow-territory of scaffolded and non-scaffolded arteries were harvested for in vitro vasoreactivity studies. Results: Conduit segments proximal and distal of the BVS edges showed reduced endothelium-dependent vasodilation as compared to control vessels (p ≤ 0.01), with distal segments being most prominently affected (p ≤ 0.01). Endothelial dysfunction was only observed in DM ± HFD swine and was principally due to a loss of NO. Endothelium-independent vasodilation and vasoconstriction were unaffected. Surprisingly, segments from the microcirculation distal to the BVS showed enhanced endothelium-dependent vasodilation (p < 0.01), whereas endothelium-independent vasodilation and vasoconstriction were unaltered. This enhanced vasorelaxation was only observed in DM + HFD swine, and did not appear to be either NO- or EDHF-mediated. Conclusions: Six months of BVS implantation in DM + HFD swine causes NO-mediated endothelial dysfunction in nearby coronary segments, which is accompanied by a, possibly compensatory, increase in endothelial function of the distal microcirculation. Endothelial dysfunction extending into coronary conduit segments beyond the implantation-site, is in agreement with recent reports expressing concern for late scaffold thrombosis and of early BVS failure in diabetic patients.

Published
2018

46. Activation of CECR1 in M2-like TAMs promotes paracrine stimulation-mediated glial tumor progression

Author

Zhu, Changbin, Mustafa, Dana, Zheng, Ping-Pin, van der Weiden, Marcel, Sacchetti, Andrea, Brandt, Maarten, Chrifi, Ihsan, Tempel, D., Leenen, Pieter J M, Duncker, Dirk Jan, Cheng, Caroline, Kros, Johan M, Zhu, Changbin, Mustafa, Dana, Zheng, Ping-Pin, van der Weiden, Marcel, Sacchetti, Andrea, Brandt, Maarten, Chrifi, Ihsan, Tempel, D., Leenen, Pieter J M, Duncker, Dirk Jan, Cheng, Caroline, and Kros, Johan M

Published
2017

47. Activation of CECR1 in M2-like TAMs promotes paracrine stimulation-mediated glial tumor progression

Author

Onderzoek Vrouw Hart & Vaatziekten, Other research (not in main researchprogram), Experimentele Afd. Cardiologie 2, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Circulatory Health, Zhu, Changbin, Mustafa, Dana, Zheng, Ping-Pin, van der Weiden, Marcel, Sacchetti, Andrea, Brandt, Maarten, Chrifi, Ihsan, Tempel, D., Leenen, Pieter J M, Duncker, Dirk Jan, Cheng, Caroline, Kros, Johan M, Onderzoek Vrouw Hart & Vaatziekten, Other research (not in main researchprogram), Experimentele Afd. Cardiologie 2, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, Circulatory Health, Zhu, Changbin, Mustafa, Dana, Zheng, Ping-Pin, van der Weiden, Marcel, Sacchetti, Andrea, Brandt, Maarten, Chrifi, Ihsan, Tempel, D., Leenen, Pieter J M, Duncker, Dirk Jan, Cheng, Caroline, and Kros, Johan M

Published
2017

48. Folic acid reduces doxorubicin-induced cardiomyopathy by modulating endothelial nitric oxide synthase

Author

Octavia, Yanti, Kararigas, G, Boer, Meta, Chrifi, Ihsane, Kietadisorn, R, Swinnen, M, Duimel, H, Verheyen, FK, Brandt, Maarten, Fliegner, D, Cheng, Caroline, Janssens, S, Duncker, Dirk-jan, Moens, AL, Octavia, Yanti, Kararigas, G, Boer, Meta, Chrifi, Ihsane, Kietadisorn, R, Swinnen, M, Duimel, H, Verheyen, FK, Brandt, Maarten, Fliegner, D, Cheng, Caroline, Janssens, S, Duncker, Dirk-jan, and Moens, AL

Published
2017

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