1. Mapping abnormal subcortical neurodevelopment in a cohort of Thai children with HIV
- Author
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Wade, Benjamin SC, Valcour, Victor G, Puthanakit, Thanyawee, Saremi, Arvin, Gutman, Boris A, Nir, Talia M, Watson, Christa, Aurpibul, Linda, Kosalaraksa, Ounchanum, Pradthana, Kerr, Stephen, Dumrongpisutikul, Netsiri, Visrutaratna, Pannee, Srinakarin, Jiraporn, Pothisri, Monthana, Narr, Katherine L, Thompson, Paul M, Ananworanich, Jintanat, Paul, Robert H, Jahanshad, Neda, and Groups, on behalf of the PREDICT and Resilience Study
- Subjects
Medical Microbiology ,Biomedical and Clinical Sciences ,HIV/AIDS ,Neurosciences ,Clinical Research ,Pediatric ,Infectious Diseases ,Brain Disorders ,Good Health and Well Being ,Anti-Retroviral Agents ,Asian People ,Brain ,CD4 Lymphocyte Count ,Child ,Cohort Studies ,Female ,HIV Infections ,Humans ,Infectious Disease Transmission ,Vertical ,Magnetic Resonance Imaging ,Male ,Thailand ,Neuro HIV ,Pediatric HIV ,Brain development ,Subcortical shape analysis ,MRI ,PREDICT and Resilience Study Groups ,Biological psychology ,Clinical and health psychology - Abstract
Alterations in subcortical brain structures have been reported in adults with HIV and, to a lesser extent, pediatric cohorts. The extent of longitudinal structural abnormalities in children with perinatal HIV infection (PaHIV) remains unclear. We modeled subcortical morphometry from whole brain structural magnetic resonance imaging (1.5 T) scans of 43 Thai children with PaHIV (baseline age = 11.09±2.36 years) and 50 HIV- children (11.26±2.80 years) using volumetric and surface-based shape analyses. The PaHIV sample were randomized to initiate combination antiretroviral treatment (cART) when CD4 counts were 15-24% (immediate: n = 22) or when CD4
- Published
- 2019