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438 results on '"Dumonde, D. C."'

1. Stress Proteins in Behçet's Disease and Experimental Uveitis

Author

Lehner, T., primary, Childerstone, A., additional, Pervin, K., additional, Hasan, A., additional, Direskeneli, H., additional, Stanford, M. R., additional, Whiston, R., additional, Kasp, E., additional, Dumonde, D. C., additional, Shinnick, T., additional, van der Zee, R., additional, and Mizushima, Y., additional

Published
2020
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3. Abstracts

Author

Morgan, J. G., Pereira, H. A., Sukiennicki, T., Spitznagel, J. K., Larrick, J. W., Forsdyke, D. R., Blum, S., Sideris, D. P., Forsdyke, R. E., Yu, H., Carstens, E., Hattori, T., Yamamura, Y., Ohmoto, Y., Nishida, T., Takatsuki, K., Tekamp-Olson, P., Gallegos, C., Bauer, D., McClain, J., Sherry, B., Fabre, M., van Deventer, S., Cerami, A., Napolitano, M., Modi, W. S., Seuanez, V. H., Cevario, S. J., Leonard, W. J., Schall, T., Toy, K., Goeddel, D. V., Hébert, C. A., Luscinskas, F. W., Kiely, J-M., Luis, E. A., Darbonne, W. C., Bennett, G. T., Liu, C. C., Obin, M. S., Gimbrone, M. A., Jr, Baker, J. B., Brown, K. A., Le Roy, F., Noble, G., Bacon, K., Camp, R., Vora, A., Dumonde, D. C., Collins, P. D., Jose, P. J., Williams, T. J., Rampart, M., Van Damme, J., Fiers, W., Herman, A. G., Pos, O., Geertsma, M. F., Stevenhagen, A., Nibbering, P. N., van Furth, R., Bacon, K. B., Camp, R. D. R., Millar, A. B., Meager, A., Semple, S. J. G., Rook, G. A. W., Stein, M., Gordon, S., Morrison, K., Jones, D. B., Jones, E. Y., Stuart, D. I., Walker, N. P. C., Thomsen, M. K., Larsen, C. G., Thestrup-Pedersen, K., Kristensen, M., Paludan, K., Deleuren, B., Kragballe, K., Matsushima, K., Wang, J. M., Taraboletti, G., Mantovani, A., Sica, A., Zachariae, K., Colditz, I., Baggiolini, M., Cunha, F. Q., Lorenzetti, B. B., Ferreira, S. H., Standiford, T. J., Kunkel, S. L., Strieter, R. M., Chensue, S. W., Westwick, J., Kasahara, K., Ribeiro, R. A., Faccioli, L. H., Souza, G. E. P., Flores, C. A., Quinn, D. G., Haslberger, A., Foster, C., Ceska, M., Ryder, N., Kugler, E., Lindley, I., Barker, J. N. W. N., Jones, M. L., Mitra, R. S., Swenson, C., Johnson, K., Fantone, J. C., Dixit, V. M., Nickoloff, B. J., Lam, C., Klein, L., Tuschil, A., Shyy, J. Y., Li, Y. S., Massop, D. W., Cornhill, J. F., Kolattukudy, P. E., Pleass, R., Brown, Z., Fairbanks, L., Thomas, R., Westwick, J., editor, Lindley, I. J. D., editor, and Kunkel, S. L., editor

Published
1991
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13. Abstracts

Author

Morgan, J. G., primary, Pereira, H. A., additional, Sukiennicki, T., additional, Spitznagel, J. K., additional, Larrick, J. W., additional, Forsdyke, D. R., additional, Blum, S., additional, Sideris, D. P., additional, Forsdyke, R. E., additional, Yu, H., additional, Carstens, E., additional, Hattori, T., additional, Yamamura, Y., additional, Ohmoto, Y., additional, Nishida, T., additional, Takatsuki, K., additional, Tekamp-Olson, P., additional, Gallegos, C., additional, Bauer, D., additional, McClain, J., additional, Sherry, B., additional, Fabre, M., additional, van Deventer, S., additional, Cerami, A., additional, Napolitano, M., additional, Modi, W. S., additional, Seuanez, V. H., additional, Cevario, S. J., additional, Leonard, W. J., additional, Schall, T., additional, Toy, K., additional, Goeddel, D. V., additional, Hébert, C. A., additional, Luscinskas, F. W., additional, Kiely, J-M., additional, Luis, E. A., additional, Darbonne, W. C., additional, Bennett, G. T., additional, Liu, C. C., additional, Obin, M. S., additional, Gimbrone, M. A., additional, Baker, J. B., additional, Brown, K. A., additional, Le Roy, F., additional, Noble, G., additional, Bacon, K., additional, Camp, R., additional, Vora, A., additional, Dumonde, D. C., additional, Collins, P. D., additional, Jose, P. J., additional, Williams, T. J., additional, Rampart, M., additional, Van Damme, J., additional, Fiers, W., additional, Herman, A. G., additional, Pos, O., additional, Geertsma, M. F., additional, Stevenhagen, A., additional, Nibbering, P. N., additional, van Furth, R., additional, Bacon, K. B., additional, Camp, R. D. R., additional, Millar, A. B., additional, Meager, A., additional, Semple, S. J. G., additional, Rook, G. A. W., additional, Stein, M., additional, Gordon, S., additional, Morrison, K., additional, Jones, D. B., additional, Jones, E. Y., additional, Stuart, D. I., additional, Walker, N. P. C., additional, Thomsen, M. K., additional, Larsen, C. G., additional, Thestrup-Pedersen, K., additional, Kristensen, M., additional, Paludan, K., additional, Deleuren, B., additional, Kragballe, K., additional, Matsushima, K., additional, Wang, J. M., additional, Taraboletti, G., additional, Mantovani, A., additional, Sica, A., additional, Zachariae, K., additional, Colditz, I., additional, Baggiolini, M., additional, Cunha, F. Q., additional, Lorenzetti, B. B., additional, Ferreira, S. H., additional, Standiford, T. J., additional, Kunkel, S. L., additional, Strieter, R. M., additional, Chensue, S. W., additional, Westwick, J., additional, Kasahara, K., additional, Ribeiro, R. A., additional, Faccioli, L. H., additional, Souza, G. E. P., additional, Flores, C. A., additional, Quinn, D. G., additional, Haslberger, A., additional, Foster, C., additional, Ceska, M., additional, Ryder, N., additional, Kugler, E., additional, Lindley, I., additional, Barker, J. N. W. N., additional, Jones, M. L., additional, Mitra, R. S., additional, Swenson, C., additional, Johnson, K., additional, Fantone, J. C., additional, Dixit, V. M., additional, Nickoloff, B. J., additional, Lam, C., additional, Klein, L., additional, Tuschil, A., additional, Shyy, J. Y., additional, Li, Y. S., additional, Massop, D. W., additional, Cornhill, J. F., additional, Kolattukudy, P. E., additional, Pleass, R., additional, Brown, Z., additional, Fairbanks, L., additional, and Thomas, R., additional

Published
1991
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36. The protective effects of omega-6 fatty acids in experimental autoimmune encephalomyelitis (EAE) in relation to transforming growth factor-beta 1 (TGF-beta1) up-regulation and increased prostaglandin E2 (PGE2) production

Author

Harbige, L S, Layward, L, Morris-Downes, M M, Dumonde, D C, Amor, S, Pathology, Amsterdam Neuroscience - Neuroinfection & -inflammation, and AII - Inflammatory diseases

Abstract

Polyunsaturated fatty acids are known to affect the immune response and administration of the omega-6 fatty acid linoleic acid has been reported to be beneficial in multiple sclerosis (MS) and EAE. In this study we have investigated the effects of oral feeding of plant lipid rich in the omega-6 fatty acid gamma-linolenic acid from Borago officinalis on acute and relapse disease and the immune response in EAE using SJL mice. EAE was induced by an encephalitogenic peptide (92-106) of myelin oligodendrocyte glycoprotein (MOG), and mice were fed the plant lipid daily from 7 days after EAE induction to assess the effects on acute disease and from day 25 to assess the effects on disease relapse. The clinical incidence and histological manifestations of acute EAE, and the clinical relapse phase of chronic relapsing EAE (CREAE) were markedly inhibited by omega-6 fatty acid feeding. A significant increase in the production of TGF-beta1 in response to concanavalin A (Con A) at day 13 and a significant increase in TGF-beta1 and PGE2 to Con A, PPD and MOG peptide (92-106) at day 21 were detected in spleen mononuclear cells from fatty acid-fed mice. There was no difference in interferon-gamma, IL-4 and IL-2 production between the fatty acid-fed and control groups. Significantly higher TGF-beta mRNA expression was found in the spleens of omega-6 fatty acid-fed mice at day 21. There were no differences in spleen cell proliferative response to Con A, PPD and MOG peptide (92-106). Biochemical analysis of spleen cell membrane fatty acids revealed significant increases in the eicosanoid precursor fatty acids dihomo-gamma-linolenic acid and arachidonic acid in response to gamma-linolenic acid feeding, indicating rapid metabolism to longer chain omega-6 fatty acids. These results show that oral feeding of gamma-linolenic acid-rich plant lipid markedly affects the disease course of acute EAE and CREAE and is associated with an increase in cell membrane long chain omega-6 fatty acids, production of PGE2 and gene transcription and, on activation, secretion of TGF-beta1.

Published
2000

37. Selective up-regulation of human granulocyte integrins and complement receptor 1 by cytokines

Author

Gloria Astrid Limb, Hamblin, A. S., Wolstencroft, R. A., and Dumonde, D. C.

Subjects
Integrins, Antigens, CD, CD11 Antigens, CD18 Antigens, Dose-Response Relationship, Immunologic, Receptors, Complement 3b, Cytokines, Humans, Cycloheximide, Cells, Cultured, Research Article, Granulocytes, Receptors, Complement
Abstract

The percentage of human granulocytes expressing the integrins CD11b and CD11c as well as complement receptor 1 (CD35) was increased by short-term incubation of whole blood with interleukin-2 (IL-2), interleukin-4 (IL-4) and tumour necrosis factors alpha and beta (TNF-alpha and TNF-beta). The mean fluorescence intensity of granulocyte CD18 was also increased by the above cytokines, whilst that of CD11b was only increased by TNF-alpha. Up-regulation of granulocyte CD18 expression was seen with 1 U/ml of IL-2, TNF-alpha or TNF-beta, in contrast to the effect of IL-4 which was only observed with 100 U/ml. Similarly, enhanced expression of CD35 was induced by 1 U/ml of IL-2 or TNF-alpha but not by concentrations of IL-4 or TNF-beta lower than 100 U/ml. Cytokine effects on the CD11/CD18 complex and CD35 molecules were not modified by cycloheximide, suggesting that their increased expression was not due simply to synthesis de novo. None of the granulocyte surface determinants investigated was altered upon short-term incubation of blood with either IL-1, IL-6 or interferon-gamma (IFN-gamma). The demonstration in vitro that cytokines selectively up-regulate granulocyte integrins and complement receptor 1, suggests that similar mechanisms may be operating during the control of granulocyte-mediated inflammatory processes.

Published
1991

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