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41 results on '"Dufrusine, Beatrice"'

3. Unveiling the immunomodulatory shift: Epithelial-mesenchymal transition Alters immune mechanisms of amniotic epithelial cells

Author

Di Lollo, Valeria, Canciello, Angelo, Peserico, Alessia, Orsini, Massimiliano, Russo, Valentina, Cerveró-Varona, Adrián, Dufrusine, Beatrice, El Khatib, Mohammad, Curini, Valentina, Mauro, Annunziata, Berardinelli, Paolo, Tournier, Cathy, Ancora, Massimo, Cammà, Cesare, Dainese, Enrico, Mincarelli, Luana Fiorella, and Barboni, Barbara

Published
2023
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4. Pancreatic beta-cell specific BAG3 knockout results in chronic hyperinsulinemia inducing insulin resistance

Author

Damiani, Verena, Lamolinara, Alessia, Cicalini, Ilaria, Cufaro, Maria Concetta, Del Pizzo, Francesco, Di Marco, Federica, Del Boccio, Piero, Dufrusine, Beatrice, Hahne, Michael, Lattanzio, Rossano, Pieragostino, Damiana, Iezzi, Manuela, Federici, Massimo, Turco, Maria Caterina, Maiorana, Arianna, Dionisi-Vici, Carlo, and De Laurenzi, Vincenzo

Published
2023
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6. Development and validation of a novel method for evaluation of multiple islet autoantibodies in dried blood spot using dissociation‐enhanced lanthanide fluorescent immunoassays technology, specific and suitable for paediatric screening programmes.

Author

Dufrusine, Beatrice, Natale, Luca, Sallese, Michele, Mozzillo, Enza, Di Candia, Francesca, Cuccurullo, Irene, Iafusco, Dario, Zanfardino, Angela, Passariello, Luana, Iannilli, Antonio, Santarelli, Sara, Federici, Luca, De Laurenzi, Vincenzo, Cherubini, Valentino, and Pieragostino, Damiana

Subjects
*TYPE 1 diabetes, *TYPE 2 diabetes, *DIABETES in children, *ENZYME-linked immunosorbent assay, *CHILD patients, *DIABETIC acidosis, *AUTOANTIBODIES
Abstract

The article discusses the development and validation of a new method for evaluating multiple islet autoantibodies in dried blood spots, specifically for pediatric screening programs. The study was conducted in Italy as part of a national screening program for type 1 diabetes and celiac disease. The method uses dissociation-enhanced lanthanide fluorescent immunoassays (DELFIA) technology on dried blood spots, providing a simple and reliable alternative to venous blood sampling. The results show that the DELFIA multiplex assay is effective in detecting autoantibodies with good sensitivity and specificity, making it a viable option for T1D screening programs. [Extracted from the article]

Published
2025
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7. Graphene oxide accelerates TGFβ-mediated epithelial-mesenchymal transition and stimulates pro-inflammatory immune response in amniotic epithelial cells

Author

Cerverò-Varona, Adrian, primary, Canciello, Angelo, additional, Peserico, Alessia, additional, Haidar Montes, Arlette Alina, additional, Citeroni, Maria Rita, additional, Mauro, Annunziata, additional, Russo, Valentina, additional, Moffa, Samanta, additional, Pilato, Serena, additional, Di Giacomo, Stefano, additional, Dufrusine, Beatrice, additional, Dainese, Enrico, additional, Fontana, Antonella, additional, and Barboni, Barbara, additional

Published
2023
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16. Extracellular LGALS3BP : a potential disease marker and actionable target for antibody–drug conjugate therapy in glioblastoma

Author

Dufrusine, Beatrice, primary, Capone, Emily, additional, Ponziani, Sara, additional, Lattanzio, Rossano, additional, Lanuti, Paola, additional, Giansanti, Francesco, additional, De Laurenzi, Vincenzo, additional, Iacobelli, Stefano, additional, Ippoliti, Rodolfo, additional, Mangiola, Annunziato, additional, Trevisi, Gianluca, additional, and Sala, Gianluca, additional

Published
2023
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18. Characterization of Nero Antico di Pretalucente Wine and Grape Fungal Microbiota: An Expression of Abruzzo Region Cultivar Heritage

Author

Perpetuini, Giorgia, primary, Rossetti, Alessio Pio, additional, Giordano, Lucia, additional, Pulcini, Marta, additional, Dufrusine, Beatrice, additional, Battistelli, Noemi, additional, Zulli, Camillo, additional, Arfelli, Giuseppe, additional, Palliotti, Alberto, additional, Dainese, Enrico, additional, and Tofalo, Rosanna, additional

Published
2023
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19. Iron Dyshomeostasis in COVID-19: Biomarkers Reveal a Functional Link to 5-Lipoxygenase Activation

Author

Dufrusine, Beatrice, primary, Valentinuzzi, Silvia, additional, Bibbò, Sandra, additional, Damiani, Verena, additional, Lanuti, Paola, additional, Pieragostino, Damiana, additional, Del Boccio, Piero, additional, D’Alessandro, Ersilia, additional, Rabottini, Alberto, additional, Berghella, Alessandro, additional, Allocati, Nerino, additional, Falasca, Katia, additional, Ucciferri, Claudio, additional, Mucedola, Francesco, additional, Di Perna, Marco, additional, Martino, Laura, additional, Vecchiet, Jacopo, additional, De Laurenzi, Vincenzo, additional, and Dainese, Enrico, additional

Published
2022
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20. Tendon 3D Scaffolds Establish a Tailored Microenvironment Instructing Paracrine Mediated Regenerative Amniotic Epithelial Stem Cells Potential

Author

Russo, Valentina, primary, El Khatib, Mohammad, additional, Prencipe, Giuseppe, additional, Mauro, Annunziata, additional, Di Giacinto, Oriana, additional, Haidar-Montes, Arlette A., additional, Pulcini, Fanny, additional, Dufrusine, Beatrice, additional, Cerveró-Varona, Adrián, additional, Faydaver, Melisa, additional, Di Berardino, Chiara, additional, Dainese, Enrico, additional, Berardinelli, Paolo, additional, Schnabelrauch, Matthias, additional, and Barboni, Barbara, additional

Published
2022
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23. Proteomics Approach Highlights Early Changes in Human Fibroblasts-Pancreatic Ductal Adenocarcinoma Cells Crosstalk

Author

Damiani, Verena, primary, Cufaro, Maria Concetta, additional, Fucito, Maurine, additional, Dufrusine, Beatrice, additional, Rossi, Claudia, additional, Del Boccio, Piero, additional, Federici, Luca, additional, Turco, Maria Caterina, additional, Sallese, Michele, additional, Pieragostino, Damiana, additional, and De Laurenzi, Vincenzo, additional

Published
2022
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24. Cover Image, Volume 123, Number 1, January 2022

Author

Dufrusine, Beatrice, primary, Damiani, Verena, additional, Capone, Emily, additional, Pieragostino, Damiana, additional, Dainese, Enrico, additional, De Marco, Margot, additional, Reppucci, Francesca, additional, Turco, Maria C., additional, Rosati, Alessandra, additional, Marzullo, Liberato, additional, Sala, Gianluca, additional, Sallese, Michele, additional, and De Laurenzi, Vincenzo, additional

Published
2022
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25. Iron Dyshomeostasis in COVID-19: Biomarkers Reveal a Functional Link to 5-Lipoxygenase Activation.

Author

Dufrusine, Beatrice, Valentinuzzi, Silvia, Bibbò, Sandra, Damiani, Verena, Lanuti, Paola, Pieragostino, Damiana, Del Boccio, Piero, D'Alessandro, Ersilia, Rabottini, Alberto, Berghella, Alessandro, Allocati, Nerino, Falasca, Katia, Ucciferri, Claudio, Mucedola, Francesco, Di Perna, Marco, Martino, Laura, Vecchiet, Jacopo, De Laurenzi, Vincenzo, and Dainese, Enrico

Subjects
*CERULOPLASMIN, *COVID-19, *POST-acute COVID-19 syndrome, *TRANSFERRIN, *IRON metabolism, *BIOMARKERS, *IRON proteins
Abstract

Coronavirus disease 2019 (COVID-19) is characterized by a broad spectrum of clinical symptoms. After acute infection, some subjects develop a post-COVID-19 syndrome known as long-COVID. This study aims to recognize the molecular and functional mechanisms that occur in COVID-19 and long-COVID patients and identify useful biomarkers for the management of patients with COVID-19 and long-COVID. Here, we profiled the response to COVID-19 by performing a proteomic analysis of lymphocytes isolated from patients. We identified significant changes in proteins involved in iron metabolism using different biochemical analyses, considering ceruloplasmin (Cp), transferrin (Tf), hemopexin (HPX), lipocalin 2 (LCN2), and superoxide dismutase 1 (SOD1). Moreover, our results show an activation of 5-lipoxygenase (5-LOX) in COVID-19 and in long-COVID possibly through an iron-dependent post-translational mechanism. Furthermore, this work defines leukotriene B4 (LTB4) and lipocalin 2 (LCN2) as possible markers of COVID-19 and long-COVID and suggests novel opportunities for prevention and treatment. [ABSTRACT FROM AUTHOR]

Published
2023
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26. Proteomic Analysis of Marinesco–Sjogren Syndrome Fibroblasts Indicates Pro-Survival Metabolic Adaptation to SIL1 Loss

Author

Potenza, Francesca, primary, Cufaro, Maria, additional, Di Biase, Linda, additional, Panella, Valeria, additional, Di Campli, Antonella, additional, Ruggieri, Anna, additional, Dufrusine, Beatrice, additional, Restelli, Elena, additional, Pietrangelo, Laura, additional, Protasi, Feliciano, additional, Pieragostino, Damiana, additional, De Laurenzi, Vincenzo, additional, Federici, Luca, additional, Chiesa, Roberto, additional, and Sallese, Michele, additional

Published
2021
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27. BAG3 induces fibroblasts to release key cytokines involved in pancreatic cell migration

Author

Dufrusine, Beatrice, primary, Damiani, Verena, additional, Capone, Emily, additional, Pieragostino, Damiana, additional, Dainese, Enrico, additional, De Marco, Margot, additional, Reppucci, Francesca, additional, Turco, Maria C., additional, Rosati, Alessandra, additional, Marzullo, Liberato, additional, Sala, Gianluca, additional, Sallese, Michele, additional, and De Laurenzi, Vincenzo, additional

Published
2021
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28. Insight into Hypoxia Stemness Control

Author

Di Mattia, Miriam, primary, Mauro, Annunziata, additional, Citeroni, Maria Rita, additional, Dufrusine, Beatrice, additional, Peserico, Alessia, additional, Russo, Valentina, additional, Berardinelli, Paolo, additional, Dainese, Enrico, additional, Cimini, Annamaria, additional, and Barboni, Barbara, additional

Published
2021
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29. Normal breathing releases SARS-CoV-2 into the air

Author

Di Carlo, Piero, primary, Falasca, Katia, additional, Ucciferri, Claudio, additional, Sinjari, Bruna, additional, Aruffo, Eleonora, additional, Antonucci, Ivana, additional, Di Serafino, Alessandra, additional, Pompilio, Arianna, additional, Damiani, Verena, additional, Mandatori, Domitilla, additional, De Fabritiis, Simone, additional, Dufrusine, Beatrice, additional, Capone, Emily, additional, Chiacchiaretta, Piero, additional, Brune, William H., additional, Di Bonaventura, Giovanni, additional, and Vecchiet, Jacopo, additional

Published
2021
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31. USP19 modulates cancer cell migration and invasion and acts as a novel prognostic marker in patients with early breast cancer

Author

Rossi, Fabiana A, primary, Steinberg, Juliana H Enriqué, additional, Roitberg, Ezequiel H Calvo, additional, Joshi, Molishree, additional, Pandey, Ahwan, additional, Abba, Martin C, additional, Dufrusine, Beatrice, additional, Buglioni, Simonetta, additional, De Laurenzi, Vincenzo, additional, Sala, Gianluca, additional, Lattanzio, Rossano, additional, Espinosa, Joaquín M, additional, and Rossi, Mario, additional

Published
2020
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40. Role of palmitoylation of cysteine 415 in functional coupling CB1 receptor to Gαi2 protein.

Author

Oddi, Sergio, Totaro, Antonio, Scipioni, Lucia, Dufrusine, Beatrice, Stepniewski, Tomasz Maciej, Selent, Jana, Maccarrone, Mauro, and Dainese, Enrico

Subjects
PALMITOYLATION, POST-translational modification, G proteins, MEMBRANE proteins, CYTOHESINS
Abstract

Abstract: In this study, we investigated the role of CB1 palmitoylation in modulating the functional interaction with G proteins both in the absence and presence of agonist binding. Our data show that the nonpalmitoylated CB1 receptor significantly reduced its association with Gαi2. The agonist stimulation induced a partial dissociation of Gαi2 proteins from the wild‐type receptor, while on the C415A mutant the agonist binding was not able to induce a significant dissociation of Gαi2 from the receptor. The lack of palmitoyl chain seems to hamper the ability of the receptor to functionally interact with the Gαi2 and indicate that the palmitoyl chain is responsible for the functional transmission of the agonist‐induced conformational change in the receptor of the G protein. These data were further corroborated by molecular dynamics simulations. Overall these results suggest that palmitoylation of the CB1 receptor finely tunes its interaction with G proteins and serves as a targeting signal for its functional regulation. Of note, the possibility to reversibly modulate the palmitoylation of CB1 receptor may offer a coordinated process of regulation and could open new therapeutic approaches. [ABSTRACT FROM AUTHOR]

Published
2018
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41. Green synthesis and two-step chromatographic separation of thiocanthal and thiocanthol: Two novel biologically active sulfur derivatives of oleocanthal and oleacein from extra virgin olive oil.

Author

Di Risola, Daniel, Mattioli, Roberto, Federico, Rodolfo, Pascarella, Gianmarco, Fontana, Mario, Dainese, Enrico, Dufrusine, Beatrice, Ciogli, Alessia, Gasparrini, Francesco, Morea, Veronica, Villani, Claudio, Mosca, Luciana, and Francioso, Antonio

Subjects
*SUSTAINABLE chemistry, *COMPUTATIONAL chemistry, *CHEMICAL purification, *ATOMIC mass, *MOLECULAR docking
Abstract

Oleocanthal and oleacein are the two major secoiridoids exclusively present in extra virgin olive oil (EVOO). Both compounds exert important pharmacological activities, including anti-inflammatory, anti-tumoral, neuro- and cardiovascular protective effects. Due to their enormous potential as possible drugs the extraction of these two bioactive natural products from EVOO has been extensively investigated in the last years and is generally supported by the use of organic chemistry. It is quite difficult to produce large quantities of these two compounds, either by organic solvent extraction and purification or by chemical synthesis, and furthermore organic processes such as cleaning, defatting, and extraction of EVOO pose a threat to the environment and are potentially harmful to workers. In this work we set up a novel aqueous extraction and isolation method from EVOO by transforming oleocanthal and oleacein into two water-soluble sulfonated products. The two derived compounds, here named thiocanthal and thiocanthol, were isolated by a two-step organic free chromatographic strategy, chemically characterized, and evaluated for their inhibitory activity on cyclooxygenase (COX). The results demonstrate that thiocanthal and thiocanthol possess anti-inflammatory effect, which is comparable to their precursors and higher than the well-known non-steroidal anti-inflammatory drug ibuprofen. Computational docking studies were performed to obtain and analyse putative models of the interaction of thiocanthal and thiocanthol with COX-1 and COX-2 binding sites. Predicted binding energy values suggested that both compounds might preferentially bind COX-2, which may have a significant pharmacological impact. Therefore, thiocanthal and thiocanthol, obtained by this novel green process, are extremely interesting both as new bioactive compounds per se and as lead compounds for the development of novel non-steroidal anti-inflammatory drugs (NSAIDs). [Display omitted] • Green synthesis of two novel water-soluble secoiridoids starting from EVOO. • Isolation of the sulfur-derivatives using aqueous-based chromatographic strategies. • Thiocanthal and thiocanthol demonstrate in-vitro anti-inflammatory properties. • In-silico studies suggested a possible COX-2 selective inhibition activity. [ABSTRACT FROM AUTHOR]

Published
2025
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