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128 results on '"Duell, E J"'

1. SEROLOGIC MARKERS OF CHLAMYDIA TRACHOMATIS AND OTHER SEXUALLY TRANSMITTED INFECTIONS AND SUBSEQUENT OVARIAN CANCER RISK: RESULTS FROM THE EPIC COHORT: EP874

Author: Idahl, A, Le Cornet, C, Maldonado, González S, Waterboer, T, Bender, N, Tjønneland, A, Hansen, L, Boutron-Ruault, M-C, Fournier, A, Kvaskoff, M, Boeing, H, Trichopoulou, A, Valanou, E, Peppa, E, Palli, D, Agnoli, C, Mattiello, A, Tumino, R, Sacerdote, C, Onland-Moret, C, Gram, I T, Weiderpass, E, Quirós, J R, Duell, E J, Sánchez, M-J, Chirlaque, M-D, Barricarte, A, Gil, L, Brändstedt, J, Riesbeck, K, Lundin, E, Khaw, K-T, Perez-Cornago, A, Gunter, M, Dossus, L, Kaaks, R, and Fortner, Turzanski R
Published: 2019
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2. Dietary acrylamide and the risk of pancreatic cancer in the International Pancreatic Cancer Case–Control Consortium (PanC4)

Author: Pelucchi, C., Rosato, V., Bracci, P. M., Li, D., Neale, R. E., Lucenteforte, E., Serraino, D., Anderson, K. E., Fontham, E., Holly, E. A., Hassan, M. M., Polesel, J., Bosetti, C., Strayer, L., Su, J., Boffetta, P., Duell, E. J., and La Vecchia, C.
Published: 2017
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3. Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation to pancreatic cancer risk: a study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Grote, V. A., Rohrmann, S., Nieters, A., Dossus, L., Tjønneland, A., Halkjær, J., Overvad, K., Fagherazzi, G., Boutron-Ruault, M. C., Morois, S., Teucher, B., Becker, S., Sluik, D., Boeing, H., Trichopoulou, A., Lagiou, P., Trichopoulos, D., Palli, D., Pala, V., Tumino, R., Vineis, P., Panico, S., Rodríguez, L., Duell, E. J., Molina-Montes, E., Dorronsoro, M., Huerta, J. M., Ardanaz, E., Jeurnink, S. M., Beulens, J. W. J., Peeters, P. H. M., Sund, M., Ye, W., Lindkvist, B., Johansen, D., Khaw, K. T., Wareham, N., Allen, N., Crowe, F., Jenab, M., Romieu, I., Michaud, D. S., Riboli, E., Romaguera, D., Bueno-de-Mesquita, H. B., and Kaaks, R.
Published: 2011
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4. Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium

Author: Bosetti, C., Rosato, V., Li, D., Silverman, D., Petersen, G. M., Bracci, P. M., Neale, R. E., Muscat, J., Anderson, K., Gallinger, S., Olson, S. H., Miller, A. B., Bas Bueno-de-Mesquita, H., Scelo, G., Janout, V., Holcatova, I., Lagiou, P., Serraino, D., Lucenteforte, E., Fabianova, E., Ghadirian, P., Baghurst, P. A., Zatonski, W., Foretova, L., Fontham, E., Bamlet, W. R., Holly, E. A., Negri, E., Hassan, M., Prizment, A., Cotterchio, M., Cleary, S., Kurtz, R. C., Maisonneuve, P., Trichopoulos, D., Polesel, J., Duell, E. J., Boffetta, P., and La Vecchia, C.
Published: 2014
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5. Dietary intake of acrylamide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Obón-Santacana, M., Slimani, N., Lujan-Barroso, L., Travier, N., Hallmans, G., Freisling, H., Ferrari, P., Boutron-Ruault, M. C., Racine, A., Clavel, F., Saieva, C., Pala, V., Tumino, R., Mattiello, A., Vineis, P., Argüelles, M., Ardanaz, E., Amiano, P., Navarro, C., Sánchez, M. J., Molina Montes, E., Key, T., Khaw, K.-T., Wareham, N., Peeters, P. H., Trichopoulou, A., Bamia, C., Trichopoulos, D., Boeing, H., Kaaks, R., Katzke, V., Ye, W., Sund, M., Ericson, U., Wirfält, E., Overvad, K., Tjønneland, A., Olsen, A., Skeie, G., Åsli, L. A., Weiderpass, E., Riboli, E., Bueno-de-Mesquita, H. B., and Duell, E. J.
Published: 2013
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6. Pancreatitis and pancreatic cancer risk: a pooled analysis in the International Pancreatic Cancer Case-Control Consortium (PanC4)

Author: Duell, E. J., Lucenteforte, E., Olson, S. H., Bracci, P. M., Li, D., Risch, H. A., Silverman, D. T., Ji, B. T., Gallinger, S., Holly, E. A., Fontham, E. H., Maisonneuve, P., Bueno-de-Mesquita, H. B., Ghadirian, P., Kurtz, R. C., Ludwig, E., Yu, H., Lowenfels, A. B., Seminara, D., Petersen, G. M., La Vecchia, C., and Boffetta, P.
Published: 2012
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7. Cigarette smoking and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (Panc4)

Author: Bosetti, C., Lucenteforte, E., Silverman, D. T., Petersen, G., Bracci, P. M., Ji, B. T., Negri, E., Li, D., Risch, H. A., Olson, S. H., Gallinger, S., Miller, A. B., Bueno-de-Mesquita, H. B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P. A., Zatonski, W., Fontham, E., Bamlet, W. R., Holly, E. A., Bertuccio, P., Gao, Y. T., Hassan, M., Yu, H., Kurtz, R. C., Cotterchio, M., Su, J., Maisonneuve, P., Duell, E. J., Boffetta, P., and La Vecchia, C.
Published: 2012
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8. Helicobacter pylori infection assessed by ELISA and by immunoblot and noncardia gastric cancer risk in a prospective study: the Eurgast-EPIC project

Author: González, C. A., Megraud, F., Buissonniere, A., Lujan Barroso, L., Agudo, A., Duell, E. J., Boutron-Ruault, M. C., Clavel-Chapelon, F., Palli, D., Krogh, V., Mattiello, A., Tumino, R., Sacerdote, C., Quirós, J. R., Sanchez-Cantalejo, E., Navarro, C., Barricarte, A., Dorronsoro, M., Khaw, K.-T., Wareham, N., Allen, N. E., Tsilidis, K. K., Bas Bueno-de-Mesquita, H., Jeurnink, S. M., Numans, M. E., Peeters, P. H. M., Lagiou, P., Valanou, E., Trichopoulou, A., Kaaks, R., Lukanova-McGregor, A., Bergman, M. M., Boeing, H., Manjer, J., Lindkvist, B., Stenling, R., Hallmans, G., Mortensen, L. M., Overvad, K., Olsen, A., Tjonneland, A., Bakken, K., Dumeaux, V., Lund, E., Jenab, M., Romieu, I., Michaud, D., Mouw, T., Carneiro, F., Fenge, C., and Riboli, E.
Published: 2012
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9. Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case–Control Consortium (PanC4)

Author: Lucenteforte, E., La Vecchia, C., Silverman, D., Petersen, G. M., Bracci, P. M., Ji, B. T., Bosetti, C., Li, D., Gallinger, S., Miller, A. B., Bueno-de-Mesquita, H. B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P. A., Zatonski, W., Fontham, E., Bamlet, W. R., Holly, E. A., Gao, Y. T., Negri, E., Hassan, M., Cotterchio, M., Su, J., Maisonneuve, P., Boffetta, P., and Duell, E. J.
Published: 2012
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10. Primary brain tumours and specific serum immunoglobulin E: a case–control study nested in the European Prospective Investigation into Cancer and Nutrition cohort

Author: Schlehofer, B., Siegmund, B., Linseisen, J., Schüz, J., Rohrmann, S., Becker, S., Michaud, D., Melin, B., Bueno-de-Mesquita, Bas H., Peeters, P. H. M., Vineis, P., Tjonneland, A., Olsen, A., Overvad, K., Romieu, I., Boeing, H., Aleksandrova, K., Trichopoulou, A., Bamia, C., Lagiou, P., Sacerdote, C., Palli, D., Panico, S., Sieri, S., Tumino, R., Sanchez, M.-J., Rodriguez, L., Dorronsoro, M., Duell, E. J., Chirlaque, M.-D., Barricarte, A., Borgquist, S., Manjer, J., Gallo, V., Allen, N. E., Key, T. J., Riboli, E., Kaaks, R., and Wahrendorf, J.
Published: 2011
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11. Reply to Are cohort data on smokeless tobacco use and pancreatic cancer confounded by alcohol use?

Author: Bertuccio, P., La Vecchia, C., Silverman, D. T., Petersen, G. M., Bracci, P. M., Negri, E., Li, D., Risch, H. A., Olson, S. H., Gallinger, S., Miller, A. B., Bueno-de-Mesquita, H. B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P. A., Zatonski, W., Fontham, E., Bamlet, W. R., Holly, E. A., Lucenteforte, E., Hassan, M., Yu, H., Kurtz, R. C., Cotterchio, M., Su, J., Maisonneuve, P., Duell, E. J., Bosetti, C., and Boffetta, P.
Published: 2011
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12. Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

Author: Bertuccio, P., La Vecchia, C., Silverman, D. T., Petersen, G. M., Bracci, P. M., Negri, E., Li, D., Risch, H. A., Olson, S. H., Gallinger, S., Miller, A. B., Bueno-de-Mesquita, H. B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P. A., Zatonski, W., Fontham, E. T., Bamlet, W. R., Holly, E. A., Lucenteforte, E., Hassan, M., Yu, H., Kurtz, R. C., Cotterchio, M., Su, J., Maisonneuve, P., Duell, E. J., Bosetti, C., and Boffetta, P.
Published: 2011
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13. Serologic markers of Chlamydia trachomatis and other sexually transmitted infections and subsequent ovarian cancer risk : results from the EPIC cohort

Author: Idahl, Annika, Le Cornet, C., Maldonado, S. González, Waterboer, T., Bender, N., Tjønneland, A., Hansen, L., Boutron-Ruault, M-C, Fournier, A., Kvaskoff, M., Boeing, H., Trichopoulou, A., Valanou, E., Peppa, E., Palli, D., Agnoli, C., Mattiello, A., Tumino, R., Sacerdote, C., Onland-Moret, C., Gram, I. T., Weiderpass, E., Quirós, J. R., Duell, E. J., Sánchez, M-J, Chirlaque, M-D, Barricarte, A., Gil, L., Brändstedt, J., Riesbeck, K., Lundin, Eva, Khaw, K-T, Perez-Cornago, A., Gunter, M., Dossus, L., Kaaks, R., Fortner, R. Turzanski, Idahl, Annika, Le Cornet, C., Maldonado, S. González, Waterboer, T., Bender, N., Tjønneland, A., Hansen, L., Boutron-Ruault, M-C, Fournier, A., Kvaskoff, M., Boeing, H., Trichopoulou, A., Valanou, E., Peppa, E., Palli, D., Agnoli, C., Mattiello, A., Tumino, R., Sacerdote, C., Onland-Moret, C., Gram, I. T., Weiderpass, E., Quirós, J. R., Duell, E. J., Sánchez, M-J, Chirlaque, M-D, Barricarte, A., Gil, L., Brändstedt, J., Riesbeck, K., Lundin, Eva, Khaw, K-T, Perez-Cornago, A., Gunter, M., Dossus, L., Kaaks, R., and Fortner, R. Turzanski
Abstract: Introduction/Background Sexually transmitted infections (STI) and pelvic inflammatory disease may cause damage to the fallopian tube where a substantial proportion of epithelial ovarian cancer (EOC) likely arises. The aim of this study was to determine whether Chlamydia trachomatis antibodies are associated with higher EOC risk. As secondary objectives, we investigated Mycoplasma genitalium,herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) 16, 18 and 45 and EOC risk. Methodology In a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort,791 cases and 1,669 matched controls with pre-diagnosis blood samples were analyzed. Cases and controls were matched on study center, and at blood collection age, time of day, fasting status, exogenous hormone use, menopausal status, and menstrual cycle phase. Antibodies against C. trachomatis, M. genitalium, HSV-2, and HPV 16, 18 and 45 (E6, E7, L1) were assessed using multiplex fluorescent bead-based serology. Conditional logistic regression was used to estimate relative risks (RR) and 95% confidence intervals [CI] comparing women with positive vs. negative serology. Results A total of 40% of the study population was seropositive to at least one STI. Positive serology to C. trachomatis Pgp3 antibodies was not associated with EOC risk overall, but was associated with higher risk of the mucinous histotype (RR=2.56 [95% CI=1.3–5.05]). Positive serology for chlamydia heat shock protein 60 (cHSP60-1), produced during persistent infection, was associated with higher risk of EOC overall (1.33 [1.09–1.62]) and of the serous subtype (1.42 [1.09–1.84]). None of the other evaluated STIs were associated with EOC risk overall; in analyses by histotype, HSV-2 was associated with higher risk of endometrioid EOC (2.93 [1.50–5.74]). Conclusion C. trachomatis infection may influence carcinogenesis of serous and mucinous EOC, while HSV-2 might promote endometrioid disease. Mec, Supplement: 4Meeting Abstract: EP874
Published: 2019
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14. Shared heritability and functional enrichment across six solid cancers

Author: Jiang, X. (Xia), Finucane, H. K. (Hilary K.), Schumacher, F. R. (Fredrick R.), Schmit, S. L. (Stephanie L.), Tyrer, J. P. (Jonathan P.), Han, Y. (Younghun), Michailidou, K. (Kyriaki), Lesseur, C. (Corina), Kuchenbaecker, K. B. (Karoline B.), Dennis, J. (Joe), Conti, D. V. (David V.), Casey, G. (Graham), Gaudet, M. M. (Mia M.), Huyghe, J. R. (Jeroen R.), Albanes, D. (Demetrius), Aldrich, M. C. (Melinda C.), Andrew, A. S. (Angeline S.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antoniou, A. C. (Antonis C.), Antonenkova, N. N. (Natalia N.), Arnold, S. M. (Susanne M.), Aronson, K. J. (Kristan J.), Arun, B. K. (Banu K.), Bandera, E. V. (Elisa V.), Barkardottir, R. B. (Rosa B.), Barnes, D. R. (Daniel R.), Batra, J. (Jyotsna), Beckmann, M. W. (Matthias W.), Benitez, J. (Javier), Benlloch, S. (Sara), Berchuck, A. (Andrew), Berndt, S. I. (Sonja I.), Bickeboeller, H. (Heike), Bien, S. A. (Stephanie A.), Blomqvist, C. (Carl), Boccia, S. (Stefania), Bogdanova, N. V. (Natalia V.), Bojesen, S. E. (Stig E.), Bolla, M. K. (Manjeet K.), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brenton, J. D. (James D.), Brook, M. N. (Mark N.), Brunet, J. (Joan), Brunnstrom, H. (Hans), Buchanan, D. D. (Daniel D.), Burwinkel, B. (Barbara), Butzow, R. (Ralf), Cadoni, G. (Gabriella), Caldes, T. (Trinidad), Caligo, M. A. (Maria A.), Campbell, I. (Ian), Campbell, P. T. (Peter T.), Cancel-Tassin, G. (Geraldine), Cannon-Albright, L. (Lisa), Campa, D. (Daniele), Caporaso, N. (Neil), Carvalho, A. L. (Andre L.), Chan, A. T. (Andrew T.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Chen, C. (Chu), Christiani, D. C. (David C.), Claes, K. B. (Kathleen B. M.), Claessens, F. (Frank), Clements, J. (Judith), Collee, J. M. (J. Margriet), Correa, M. C. (Marcia Cruz), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cunningham, J. M. (Julie M.), Cybulski, C. (Cezary), Czene, K. (Kamila), Daly, M. B. (Mary B.), defazio, A. (Anna), Devilee, P. (Peter), Diez, O. (Orland), Gago-Dominguez, M. (Manuela), Donovan, J. L. (Jenny L.), Doerk, T. (Thilo), Duell, E. J. (Eric J.), Dunning, A. M. (Alison M.), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Edlund, C. K. (Christopher K.), Edwards, D. R. (Digna R. Velez), Ellberg, C. (Carolina), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Ferris, R. L. (Robert L.), Liloglou, T. (Triantafillos), Figueiredo, J. C. (Jane C.), Fletcher, O. (Olivia), Fortner, R. T. (Renee T.), Fostira, F. (Florentia), Franceschi, S. (Silvia), Friedman, E. (Eitan), Gallinger, S. J. (Steven J.), Ganz, P. A. (Patricia A.), Garber, J. (Judy), Garcia-Saenz, J. A. (Jose A.), Gayther, S. A. (Simon A.), Giles, G. G. (Graham G.), Godwin, A. K. (Andrew K.), Goldberg, M. S. (Mark S.), Goldgar, D. E. (David E.), Goode, E. L. (Ellen L.), Goodman, M. T. (Marc T.), Goodman, G. (Gary), Grankvist, K. (Kjell), Greene, M. H. (Mark H.), Gronberg, H. (Henrik), Gronwald, J. (Jacek), Guenel, P. (Pascal), Hakansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Hamdy, F. C. (Freddie C.), Hamilton, R. J. (Robert J.), Hampe, J. (Jochen), Haugen, A. (Aage), Heitz, F. (Florian), Herrero, R. (Rolando), Hillemanns, P. (Peter), Hoffmeister, M. (Michael), Hogdall, E. (Estrid), Hong, Y.-C. (Yun-Chul), Hopper, J. L. (John L.), Houlston, R. (Richard), Hulick, P. J. (Peter J.), Hunter, D. J. (David J.), Huntsman, D. G. (David G.), Idos, G. (Gregory), Imyanitov, E. N. (Evgeny N.), Ingles, S. A. (Sue Ann), Isaacs, C. (Claudine), Jakubowska, A. (Anna), James, P. (Paul), Jenkins, M. A. (Mark A.), Johansson, M. (Mattias), Johansson, M. (Mikael), John, E. M. (Esther M.), Joshi, A. D. (Amit D.), Kaneva, R. (Radka), Karlan, B. Y. (Beth Y.), Kelemen, L. E. (Linda E.), Kuhl, T. (Tabea), Khaw, K.-T. (Kay-Tee), Khusnutdinova, E. (Elza), Kibel, A. S. (Adam S.), Kiemeney, L. A. (Lambertus A.), Kim, J. (Jeri), Kjaer, S. K. (Susanne K.), Knight, J. A. (Julia A.), Kogevinas, M. (Manolis), Kote-Jarai, Z. (Zsofia), Koutros, S. (Stella), Kristensen, V. N. (Vessela N.), Kupryjanczyk, J. (Jolanta), Lacko, M. (Martin), Lam, S. (Stephan), Lambrechts, D. (Diether), Landi, M. T. (Maria Teresa), Lazarus, P. (Philip), Le, N. D. (Nhu D.), Lee, E. (Eunjung), Lejbkowicz, F. (Flavio), Lenz, H.-J. (Heinz-Josef), Leslie, G. (Goska), Lessel, D. (Davor), Lester, J. (Jenny), Levine, D. A. (Douglas A.), Li, L. (Li), Li, C. I. (Christopher I.), Lindblom, A. (Annika), Lindor, N. M. (Noralane M.), Liu, G. (Geoffrey), Loupakis, F. (Fotios), Lubinski, J. (Jan), Maehle, L. (Lovise), Maier, C. (Christiane), Mannermaa, A. (Arto), Le Marchand, L. (Loic), Margolin, S. (Sara), May, T. (Taymaa), McGuffog, L. (Lesley), Meindl, A. (Alfons), Middha, P. (Pooja), Miller, A. (Austin), Milne, R. L. (Roger L.), MacInnis, R. J. (Robert J.), Modugno, F. (Francesmary), Montagna, M. (Marco), Moreno, V. (Victor), Moysich, K. B. (Kirsten B.), Mucci, L. (Lorelei), Muir, K. (Kenneth), Mulligan, A. M. (Anna Marie), Nathanson, K. L. (Katherine L.), Neal, D. E. (David E.), Ness, A. R. (Andrew R.), Neuhausen, S. L. (Susan L.), Nevanlinna, H. (Heli), Newcomb, P. A. (Polly A.), Newcomb, L. F. (Lisa F.), Nielsen, F. C. (Finn Cilius), Nikitina-Zake, L. (Liene), Nordestgaard, B. G. (Borge G.), Nussbaum, R. L. (Robert L.), Offit, K. (Kenneth), Olah, E. (Edith), Al Olama, A. A. (Ali Amin), Olopade, O. I. (Olufunmilayo I.), Olshan, A. F. (Andrew F.), Olsson, H. (Hakan), Osorio, A. (Ana), Pandha, H. (Hardev), Park, J. Y. (Jong Y.), Pashayan, N. (Nora), Parsons, M. T. (Michael T.), Pejovic, T. (Tanja), Penney, K. L. (Kathryn L.), Peters, W. H. (Wilbert H. M.), Phelan, C. M. (Catherine M.), Phipps, A. I. (Amanda I.), Plaseska-Karanfilska, D. (Dijana), Pring, M. (Miranda), Prokofyeva, D. (Darya), Radice, P. (Paolo), Stefansson, K. (Kari), Ramus, S. J. (Susan J.), Raskin, L. (Leon), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), van Rensburg, E. J. (Elizabeth J.), Riggan, M. J. (Marjorie J.), Risch, H. A. (Harvey A.), Risch, A. (Angela), Roobol, M. J. (Monique J.), Rosenstein, B. S. (Barry S.), Rossing, M. A. (Mary Anne), De Ruyck, K. (Kim), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schabath, M. B. (Matthew B.), Schleutker, J. (Johanna), Schmidt, M. K. (Marjanka K.), Setiawan, V. W. (V. Wendy), Shen, H. (Hongbing), Siegel, E. M. (Erin M.), Sieh, W. (Weiva), Singer, C. F. (Christian F.), Slattery, M. L. (Martha L.), Sorensen, K. D. (Karina Dalsgaard), Southey, M. C. (Melissa C.), Spurdle, A. B. (Amanda B.), Stanford, J. L. (Janet L.), Stevens, V. L. (Victoria L.), Stintzing, S. (Sebastian), Stone, J. (Jennifer), Sundfeldt, K. (Karin), Sutphen, R. (Rebecca), Swerdlow, A. J. (Anthony J.), Tajara, E. H. (Eloiza H.), Tangen, C. M. (Catherine M.), Tardon, A. (Adonina), Taylor, J. A. (Jack A.), Teare, M. D. (M. Dawn), Teixeira, M. R. (Manuel R.), Terry, M. B. (Mary Beth), Terry, K. L. (Kathryn L.), Thibodeau, S. N. (Stephen N.), Thomassen, M. (Mads), Bjorge, L. (Line), Tischkowitz, M. (Marc), Toland, A. E. (Amanda E.), Torres, D. (Diana), Townsend, P. A. (Paul A.), Travis, R. C. (Ruth C.), Tung, N. (Nadine), Tworoger, S. S. (Shelley S.), Ulrich, C. M. (Cornelia M.), Usmani, N. (Nawaid), Vachon, C. M. (Celine M.), Van Nieuwenhuysen, E. (Els), Vega, A. (Ana), Aguado-Barrera, M. E. (Miguel Elias), Wang, Q. (Qin), Webb, P. M. (Penelope M.), Weinberg, C. R. (Clarice R.), Weinstein, S. (Stephanie), Weissler, M. C. (Mark C.), Weitzel, J. N. (Jeffrey N.), West, C. M. (Catharine M. L.), White, E. (Emily), Whittemore, A. S. (Alice S.), Wichmann, H.-E. (H-Erich), Wiklund, F. (Fredrik), Winqvist, R. (Robert), Wolk, A. (Alicja), Woll, P. (Penella), Woods, M. (Michael), Wu, A. H. (Anna H.), Wu, X. (Xifeng), Yannoukakos, D. (Drakoulis), Zheng, W. (Wei), Zienolddiny, S. (Shanbeh), Ziogas, A. (Argyrios), Zorn, K. K. (Kristin K.), Lane, J. M. (Jacqueline M.), Saxena, R. (Richa), Thomas, D. (Duncan), Hung, R. J. (Rayjean J.), Diergaarde, B. (Brenda), Mckay, J. (James), Peters, U. (Ulrike), Hsu, L. (Li), Garcia-Closas, M. (Montserrat), Eeles, R. A. (Rosalind A.), Chenevix-Trench, G. (Georgia), Brennan, P. J. (Paul J.), Haiman, C. A. (Christopher A.), Simard, J. (Jacques), Easton, D. F. (Douglas F.), Gruber, S. B. (Stephen B.), Pharoah, P. D. (Paul D. P.), Price, A. L. (Alkes L.), Pasaniuc, B. (Bogdan), Amos, C. I. (Christopher I.), Kraft, P. (Peter), Lindstrom, S. (Sara), Jiang, X. (Xia), Finucane, H. K. (Hilary K.), Schumacher, F. R. (Fredrick R.), Schmit, S. L. (Stephanie L.), Tyrer, J. P. (Jonathan P.), Han, Y. (Younghun), Michailidou, K. (Kyriaki), Lesseur, C. (Corina), Kuchenbaecker, K. B. (Karoline B.), Dennis, J. (Joe), Conti, D. V. (David V.), Casey, G. (Graham), Gaudet, M. M. (Mia M.), Huyghe, J. R. (Jeroen R.), Albanes, D. (Demetrius), Aldrich, M. C. (Melinda C.), Andrew, A. S. (Angeline S.), Andrulis, I. L. (Irene L.), Anton-Culver, H. (Hoda), Antoniou, A. C. (Antonis C.), Antonenkova, N. N. (Natalia N.), Arnold, S. M. (Susanne M.), Aronson, K. J. (Kristan J.), Arun, B. K. (Banu K.), Bandera, E. V. (Elisa V.), Barkardottir, R. B. (Rosa B.), Barnes, D. R. (Daniel R.), Batra, J. (Jyotsna), Beckmann, M. W. (Matthias W.), Benitez, J. (Javier), Benlloch, S. (Sara), Berchuck, A. (Andrew), Berndt, S. I. (Sonja I.), Bickeboeller, H. (Heike), Bien, S. A. (Stephanie A.), Blomqvist, C. (Carl), Boccia, S. (Stefania), Bogdanova, N. V. (Natalia V.), Bojesen, S. E. (Stig E.), Bolla, M. K. (Manjeet K.), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brenton, J. D. (James D.), Brook, M. N. (Mark N.), Brunet, J. (Joan), Brunnstrom, H. (Hans), Buchanan, D. D. (Daniel D.), Burwinkel, B. (Barbara), Butzow, R. (Ralf), Cadoni, G. (Gabriella), Caldes, T. (Trinidad), Caligo, M. A. (Maria A.), Campbell, I. (Ian), Campbell, P. T. (Peter T.), Cancel-Tassin, G. (Geraldine), Cannon-Albright, L. (Lisa), Campa, D. (Daniele), Caporaso, N. (Neil), Carvalho, A. L. (Andre L.), Chan, A. T. (Andrew T.), Chang-Claude, J. (Jenny), Chanock, S. J. (Stephen J.), Chen, C. (Chu), Christiani, D. C. (David C.), Claes, K. B. (Kathleen B. M.), Claessens, F. (Frank), Clements, J. (Judith), Collee, J. M. (J. Margriet), Correa, M. C. (Marcia Cruz), Couch, F. J. (Fergus J.), Cox, A. (Angela), Cunningham, J. M. (Julie M.), Cybulski, C. (Cezary), Czene, K. (Kamila), Daly, M. B. (Mary B.), defazio, A. (Anna), Devilee, P. (Peter), Diez, O. (Orland), Gago-Dominguez, M. (Manuela), Donovan, J. L. (Jenny L.), Doerk, T. (Thilo), Duell, E. J. (Eric J.), Dunning, A. M. (Alison M.), Dwek, M. (Miriam), Eccles, D. M. (Diana M.), Edlund, C. K. (Christopher K.), Edwards, D. R. (Digna R. Velez), Ellberg, C. (Carolina), Evans, D. G. (D. Gareth), Fasching, P. A. (Peter A.), Ferris, R. L. (Robert L.), Liloglou, T. (Triantafillos), Figueiredo, J. C. (Jane C.), Fletcher, O. (Olivia), Fortner, R. T. (Renee T.), Fostira, F. (Florentia), Franceschi, S. (Silvia), Friedman, E. (Eitan), Gallinger, S. J. (Steven J.), Ganz, P. A. (Patricia A.), Garber, J. (Judy), Garcia-Saenz, J. A. (Jose A.), Gayther, S. A. (Simon A.), Giles, G. G. (Graham G.), Godwin, A. K. (Andrew K.), Goldberg, M. S. (Mark S.), Goldgar, D. E. (David E.), Goode, E. L. (Ellen L.), Goodman, M. T. (Marc T.), Goodman, G. (Gary), Grankvist, K. (Kjell), Greene, M. H. (Mark H.), Gronberg, H. (Henrik), Gronwald, J. (Jacek), Guenel, P. (Pascal), Hakansson, N. (Niclas), Hall, P. (Per), Hamann, U. (Ute), Hamdy, F. C. (Freddie C.), Hamilton, R. J. (Robert J.), Hampe, J. (Jochen), Haugen, A. (Aage), Heitz, F. (Florian), Herrero, R. (Rolando), Hillemanns, P. (Peter), Hoffmeister, M. (Michael), Hogdall, E. (Estrid), Hong, Y.-C. (Yun-Chul), Hopper, J. L. (John L.), Houlston, R. (Richard), Hulick, P. J. (Peter J.), Hunter, D. J. (David J.), Huntsman, D. G. (David G.), Idos, G. (Gregory), Imyanitov, E. N. (Evgeny N.), Ingles, S. A. (Sue Ann), Isaacs, C. (Claudine), Jakubowska, A. (Anna), James, P. (Paul), Jenkins, M. A. (Mark A.), Johansson, M. (Mattias), Johansson, M. (Mikael), John, E. M. (Esther M.), Joshi, A. D. (Amit D.), Kaneva, R. (Radka), Karlan, B. Y. (Beth Y.), Kelemen, L. E. (Linda E.), Kuhl, T. (Tabea), Khaw, K.-T. (Kay-Tee), Khusnutdinova, E. (Elza), Kibel, A. S. (Adam S.), Kiemeney, L. A. (Lambertus A.), Kim, J. (Jeri), Kjaer, S. K. (Susanne K.), Knight, J. A. (Julia A.), Kogevinas, M. (Manolis), Kote-Jarai, Z. (Zsofia), Koutros, S. (Stella), Kristensen, V. N. (Vessela N.), Kupryjanczyk, J. (Jolanta), Lacko, M. (Martin), Lam, S. (Stephan), Lambrechts, D. (Diether), Landi, M. T. (Maria Teresa), Lazarus, P. (Philip), Le, N. D. (Nhu D.), Lee, E. (Eunjung), Lejbkowicz, F. (Flavio), Lenz, H.-J. (Heinz-Josef), Leslie, G. (Goska), Lessel, D. (Davor), Lester, J. (Jenny), Levine, D. A. (Douglas A.), Li, L. (Li), Li, C. I. (Christopher I.), Lindblom, A. (Annika), Lindor, N. M. (Noralane M.), Liu, G. (Geoffrey), Loupakis, F. (Fotios), Lubinski, J. (Jan), Maehle, L. (Lovise), Maier, C. (Christiane), Mannermaa, A. (Arto), Le Marchand, L. (Loic), Margolin, S. (Sara), May, T. (Taymaa), McGuffog, L. (Lesley), Meindl, A. (Alfons), Middha, P. (Pooja), Miller, A. (Austin), Milne, R. L. (Roger L.), MacInnis, R. J. (Robert J.), Modugno, F. (Francesmary), Montagna, M. (Marco), Moreno, V. (Victor), Moysich, K. B. (Kirsten B.), Mucci, L. (Lorelei), Muir, K. (Kenneth), Mulligan, A. M. (Anna Marie), Nathanson, K. L. (Katherine L.), Neal, D. E. (David E.), Ness, A. R. (Andrew R.), Neuhausen, S. L. (Susan L.), Nevanlinna, H. (Heli), Newcomb, P. A. (Polly A.), Newcomb, L. F. (Lisa F.), Nielsen, F. C. (Finn Cilius), Nikitina-Zake, L. (Liene), Nordestgaard, B. G. (Borge G.), Nussbaum, R. L. (Robert L.), Offit, K. (Kenneth), Olah, E. (Edith), Al Olama, A. A. (Ali Amin), Olopade, O. I. (Olufunmilayo I.), Olshan, A. F. (Andrew F.), Olsson, H. (Hakan), Osorio, A. (Ana), Pandha, H. (Hardev), Park, J. Y. (Jong Y.), Pashayan, N. (Nora), Parsons, M. T. (Michael T.), Pejovic, T. (Tanja), Penney, K. L. (Kathryn L.), Peters, W. H. (Wilbert H. M.), Phelan, C. M. (Catherine M.), Phipps, A. I. (Amanda I.), Plaseska-Karanfilska, D. (Dijana), Pring, M. (Miranda), Prokofyeva, D. (Darya), Radice, P. (Paolo), Stefansson, K. (Kari), Ramus, S. J. (Susan J.), Raskin, L. (Leon), Rennert, G. (Gad), Rennert, H. S. (Hedy S.), van Rensburg, E. J. (Elizabeth J.), Riggan, M. J. (Marjorie J.), Risch, H. A. (Harvey A.), Risch, A. (Angela), Roobol, M. J. (Monique J.), Rosenstein, B. S. (Barry S.), Rossing, M. A. (Mary Anne), De Ruyck, K. (Kim), Saloustros, E. (Emmanouil), Sandler, D. P. (Dale P.), Sawyer, E. J. (Elinor J.), Schabath, M. B. (Matthew B.), Schleutker, J. (Johanna), Schmidt, M. K. (Marjanka K.), Setiawan, V. W. (V. Wendy), Shen, H. (Hongbing), Siegel, E. M. (Erin M.), Sieh, W. (Weiva), Singer, C. F. (Christian F.), Slattery, M. L. (Martha L.), Sorensen, K. D. (Karina Dalsgaard), Southey, M. C. (Melissa C.), Spurdle, A. B. (Amanda B.), Stanford, J. L. (Janet L.), Stevens, V. L. (Victoria L.), Stintzing, S. (Sebastian), Stone, J. (Jennifer), Sundfeldt, K. (Karin), Sutphen, R. (Rebecca), Swerdlow, A. J. (Anthony J.), Tajara, E. H. (Eloiza H.), Tangen, C. M. (Catherine M.), Tardon, A. (Adonina), Taylor, J. A. (Jack A.), Teare, M. D. (M. Dawn), Teixeira, M. R. (Manuel R.), Terry, M. B. (Mary Beth), Terry, K. L. (Kathryn L.), Thibodeau, S. N. (Stephen N.), Thomassen, M. (Mads), Bjorge, L. (Line), Tischkowitz, M. (Marc), Toland, A. E. (Amanda E.), Torres, D. (Diana), Townsend, P. A. (Paul A.), Travis, R. C. (Ruth C.), Tung, N. (Nadine), Tworoger, S. S. (Shelley S.), Ulrich, C. M. (Cornelia M.), Usmani, N. (Nawaid), Vachon, C. M. (Celine M.), Van Nieuwenhuysen, E. (Els), Vega, A. (Ana), Aguado-Barrera, M. E. (Miguel Elias), Wang, Q. (Qin), Webb, P. M. (Penelope M.), Weinberg, C. R. (Clarice R.), Weinstein, S. (Stephanie), Weissler, M. C. (Mark C.), Weitzel, J. N. (Jeffrey N.), West, C. M. (Catharine M. L.), White, E. (Emily), Whittemore, A. S. (Alice S.), Wichmann, H.-E. (H-Erich), Wiklund, F. (Fredrik), Winqvist, R. (Robert), Wolk, A. (Alicja), Woll, P. (Penella), Woods, M. (Michael), Wu, A. H. (Anna H.), Wu, X. (Xifeng), Yannoukakos, D. (Drakoulis), Zheng, W. (Wei), Zienolddiny, S. (Shanbeh), Ziogas, A. (Argyrios), Zorn, K. K. (Kristin K.), Lane, J. M. (Jacqueline M.), Saxena, R. (Richa), Thomas, D. (Duncan), Hung, R. J. (Rayjean J.), Diergaarde, B. (Brenda), Mckay, J. (James), Peters, U. (Ulrike), Hsu, L. (Li), Garcia-Closas, M. (Montserrat), Eeles, R. A. (Rosalind A.), Chenevix-Trench, G. (Georgia), Brennan, P. J. (Paul J.), Haiman, C. A. (Christopher A.), Simard, J. (Jacques), Easton, D. F. (Douglas F.), Gruber, S. B. (Stephen B.), Pharoah, P. D. (Paul D. P.), Price, A. L. (Alkes L.), Pasaniuc, B. (Bogdan), Amos, C. I. (Christopher I.), Kraft, P. (Peter), and Lindstrom, S. (Sara)
Abstract: Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10−8), breast and ovarian cancer (rg = 0.24, p = 7 × 10−5), breast and lung cancer (rg = 0.18, p =1.5 × 10−6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10−4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
Published: 2019

15. Publisher Correction: Shared heritability and functional enrichment across six solid cancers (Nature Communications, (2019), 10, 1, (431), 10.1038/s41467-018-08054-4)

Author: Jiang, X., Finucane, H. K., Schumacher, F. R., Schmit, S. L., Tyrer, J. P., Han, Y., Michailidou, K., Lesseur, C., Kuchenbaecker, K. B., Dennis, J., Conti, D. V., Casey, G., Gaudet, M. M., Huyghe, J. R., Albanes, D., Aldrich, M. C., Andrew, A. S., Andrulis, I. L., Anton-Culver, H., Antoniou, A. C., Antonenkova, N. N., Arnold, S. M., Aronson, K. J., Arun, B. K., Bandera, E. V., Barkardottir, R. B., Barnes, D. R., Batra, J., Beckmann, M. W., Benitez, J., Benlloch, S., Berchuck, A., Berndt, S. I., Bickeboller, H., Bien, S. A., Blomqvist, C., Boccia, S., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Brauch, H., Brenner, H., Brenton, J. D., Brook, M. N., Brunet, J., Brunnstrom, H., Buchanan, D. D., Burwinkel, B., Butzow, R., Cadoni, G., Caldes, T., Caligo, M. A., Campbell, I., Campbell, P. T., Cancel-Tassin, G., Cannon-Albright, L., Campa, D., Caporaso, N., Carvalho, A. L., Chan, A. T., Chang-Claude, J., Chanock, S. J., Chen, Chen, Christiani, D. C., Claes, K. B. M., Claessens, F., Clements, J., Collee, J. M., Correa, M. C., Couch, F. J., Cox, A., Cunningham, J. M., Cybulski, C., Czene, K., Daly, M. B., deFazio, A., Devilee, P., Diez, O., Gago-Dominguez, M., Donovan, J. L., Dork, T., Duell, E. J., Dunning, A. M., Dwek, M., Eccles, D. M., Edlund, C. K., Edwards, D. R. V., Ellberg, C., Evans, D. G., Fasching, P. A., Ferris, R. L., Liloglou, T., Figueiredo, J. C., Fletcher, O., Fortner, R. T., Fostira, F., Franceschi, S., Friedman, E., Gallinger, S. J., Ganz, P. A., Garber, J., Garcia-Saenz, J. A., Gayther, S. A., Giles, G. G., Godwin, A. K., Goldberg, M. S., Goldgar, D. E., Goode, E. L., Goodman, M. T., Goodman, G., Grankvist, K., Greene, M. H., Gronberg, H., Gronwald, J., Guenel, P., Hakansson, N., Hall, P., Hamann, U., Hamdy, F. C., Hamilton, R. J., Hampe, J., Haugen, A., Heitz, F., Herrero, R., Hillemanns, P., Hoffmeister, M., Hogdall, E., Hong, Y. -C., Hopper, J. L., Houlston, R., Hulick, P. J., Hunter, D. J., Huntsman, D. G., Idos, G., Imyanitov, E. N., Ingles, S. A., Isaacs, C., Jakubowska, A., James, P., Jenkins, M. A., Johansson, M., John, E. M., Joshi, A. D., Kaneva, R., Karlan, B. Y., Kelemen, L. E., Kuhl, T., Khaw, K. -T., Khusnutdinova, E., Kibel, A. S., Kiemeney, L. A., Kim, J., Kjaer, S. K., Knight, J. A., Kogevinas, M., Kote-Jarai, Z., Koutros, S., Kristensen, V. N., Kupryjanczyk, J., Lacko, M., Lam, S., Lambrechts, D., Landi, M. T., Lazarus, P., Le, N. D., Lee, E., Lejbkowicz, F., Lenz, H. -J., Leslie, G., Lessel, D., Lester, J., Levine, D. A., Li, L., Li, C. I., Lindblom, A., Lindor, N. M., Liu, G., Loupakis, F., Lubinski, J., Maehle, L., Maier, C., Mannermaa, A., Marchand, L. L., Margolin, S., May, T., McGuffog, L., Meindl, A., Middha, P., Miller, A., Milne, R. L., MacInnis, R. J., Modugno, F., Montagna, M., Moreno, V., Moysich, K. B., Mucci, L., Muir, K., Mulligan, A. M., Nathanson, K. L., Neal, D. E., Ness, A. R., Neuhausen, S. L., Nevanlinna, H., Newcomb, P. A., Newcomb, L. F., Nielsen, F. C., Nikitina-Zake, L., Nordestgaard, B. G., Nussbaum, R. L., Offit, K., Olah, E., Olama, A. A. A., Olopade, O. I., Olshan, A. F., Olsson, H., Osorio, A., Pandha, H., Park, J. Y., Pashayan, N., Parsons, M. T., Pejovic, T., Penney, K. L., Peters, W. H. M., Phelan, C. M., Phipps, A. I., Plaseska-Karanfilska, D., Pring, M., Prokofyeva, D., Radice, P., Stefansson, K., Ramus, S. J., Raskin, L., Rennert, G., Rennert, H. S., van Rensburg, E. J., Riggan, M. J., Risch, H. A., Risch, A., Roobol, M. J., Rosenstein, B. S., Rossing, M. A., De Ruyck, K., Saloustros, E., Sandler, D. P., Sawyer, E. J., Schabath, M. B., Schleutker, J., Schmidt, M. K., Setiawan, V. W., Shen, H., Siegel, E. M., Sieh, W., Singer, C. F., Slattery, M. L., Sorensen, K. D., Southey, M. C., Spurdle, A. B., Stanford, J. L., Stevens, V. L., Stintzing, S., Stone, J., Sundfeldt, K., Sutphen, R., Swerdlow, A. J., Tajara, E. H., Tangen, C. M., Tardon, A., Taylor, J. A., Teare, M. D., Teixeira, M. R., Terry, M. B., Terry, K. L., Thibodeau, S. N., Thomassen, M., Bjorge, L., Tischkowitz, M., Toland, A. E., Torres, D., Townsend, P. A., Travis, R. C., Tung, N., Tworoger, S. S., Ulrich, C. M., Usmani, N., Vachon, C. M., Van Nieuwenhuysen, E., Vega, A., Aguado-Barrera, M. E., Wang, Q., Webb, P. M., Weinberg, C. R., Weinstein, S., Weissler, M. C., Weitzel, J. N., West, C. M. L., White, E., Whittemore, A. S., Wichmann, H. -E., Wiklund, F., Winqvist, R., Wolk, A., Woll, P., Woods, M., Wu, A. H., Wu, X., Yannoukakos, D., Zheng, W., Zienolddiny, S., Ziogas, A., Zorn, K. K., Lane, J. M., Saxena, R., Thomas, D., Hung, R. J., Diergaarde, B., McKay, J., Peters, U., Hsu, L., Garcia-Closas, M., Eeles, R. A., Chenevix-Trench, G., Brennan, P. J., Haiman, C. A., Simard, J., Easton, D. F., Gruber, S. B., Pharoah, P. D. P., Price, A. L., Pasaniuc, B., Amos, C. I., Kraft, P., Lindstrom, S., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chen C., Liu G., Wang Q., Jiang, X., Finucane, H. K., Schumacher, F. R., Schmit, S. L., Tyrer, J. P., Han, Y., Michailidou, K., Lesseur, C., Kuchenbaecker, K. B., Dennis, J., Conti, D. V., Casey, G., Gaudet, M. M., Huyghe, J. R., Albanes, D., Aldrich, M. C., Andrew, A. S., Andrulis, I. L., Anton-Culver, H., Antoniou, A. C., Antonenkova, N. N., Arnold, S. M., Aronson, K. J., Arun, B. K., Bandera, E. V., Barkardottir, R. B., Barnes, D. R., Batra, J., Beckmann, M. W., Benitez, J., Benlloch, S., Berchuck, A., Berndt, S. I., Bickeboller, H., Bien, S. A., Blomqvist, C., Boccia, S., Bogdanova, N. V., Bojesen, S. E., Bolla, M. K., Brauch, H., Brenner, H., Brenton, J. D., Brook, M. N., Brunet, J., Brunnstrom, H., Buchanan, D. D., Burwinkel, B., Butzow, R., Cadoni, G., Caldes, T., Caligo, M. A., Campbell, I., Campbell, P. T., Cancel-Tassin, G., Cannon-Albright, L., Campa, D., Caporaso, N., Carvalho, A. L., Chan, A. T., Chang-Claude, J., Chanock, S. J., Chen, Chen, Christiani, D. C., Claes, K. B. M., Claessens, F., Clements, J., Collee, J. M., Correa, M. C., Couch, F. J., Cox, A., Cunningham, J. M., Cybulski, C., Czene, K., Daly, M. B., deFazio, A., Devilee, P., Diez, O., Gago-Dominguez, M., Donovan, J. L., Dork, T., Duell, E. J., Dunning, A. M., Dwek, M., Eccles, D. M., Edlund, C. K., Edwards, D. R. V., Ellberg, C., Evans, D. G., Fasching, P. A., Ferris, R. L., Liloglou, T., Figueiredo, J. C., Fletcher, O., Fortner, R. T., Fostira, F., Franceschi, S., Friedman, E., Gallinger, S. J., Ganz, P. A., Garber, J., Garcia-Saenz, J. A., Gayther, S. A., Giles, G. G., Godwin, A. K., Goldberg, M. S., Goldgar, D. E., Goode, E. L., Goodman, M. T., Goodman, G., Grankvist, K., Greene, M. H., Gronberg, H., Gronwald, J., Guenel, P., Hakansson, N., Hall, P., Hamann, U., Hamdy, F. C., Hamilton, R. J., Hampe, J., Haugen, A., Heitz, F., Herrero, R., Hillemanns, P., Hoffmeister, M., Hogdall, E., Hong, Y. -C., Hopper, J. L., Houlston, R., Hulick, P. J., Hunter, D. J., Huntsman, D. G., Idos, G., Imyanitov, E. N., Ingles, S. A., Isaacs, C., Jakubowska, A., James, P., Jenkins, M. A., Johansson, M., John, E. M., Joshi, A. D., Kaneva, R., Karlan, B. Y., Kelemen, L. E., Kuhl, T., Khaw, K. -T., Khusnutdinova, E., Kibel, A. S., Kiemeney, L. A., Kim, J., Kjaer, S. K., Knight, J. A., Kogevinas, M., Kote-Jarai, Z., Koutros, S., Kristensen, V. N., Kupryjanczyk, J., Lacko, M., Lam, S., Lambrechts, D., Landi, M. T., Lazarus, P., Le, N. D., Lee, E., Lejbkowicz, F., Lenz, H. -J., Leslie, G., Lessel, D., Lester, J., Levine, D. A., Li, L., Li, C. I., Lindblom, A., Lindor, N. M., Liu, G., Loupakis, F., Lubinski, J., Maehle, L., Maier, C., Mannermaa, A., Marchand, L. L., Margolin, S., May, T., McGuffog, L., Meindl, A., Middha, P., Miller, A., Milne, R. L., MacInnis, R. J., Modugno, F., Montagna, M., Moreno, V., Moysich, K. B., Mucci, L., Muir, K., Mulligan, A. M., Nathanson, K. L., Neal, D. E., Ness, A. R., Neuhausen, S. L., Nevanlinna, H., Newcomb, P. A., Newcomb, L. F., Nielsen, F. C., Nikitina-Zake, L., Nordestgaard, B. G., Nussbaum, R. L., Offit, K., Olah, E., Olama, A. A. A., Olopade, O. I., Olshan, A. F., Olsson, H., Osorio, A., Pandha, H., Park, J. Y., Pashayan, N., Parsons, M. T., Pejovic, T., Penney, K. L., Peters, W. H. M., Phelan, C. M., Phipps, A. I., Plaseska-Karanfilska, D., Pring, M., Prokofyeva, D., Radice, P., Stefansson, K., Ramus, S. J., Raskin, L., Rennert, G., Rennert, H. S., van Rensburg, E. J., Riggan, M. J., Risch, H. A., Risch, A., Roobol, M. J., Rosenstein, B. S., Rossing, M. A., De Ruyck, K., Saloustros, E., Sandler, D. P., Sawyer, E. J., Schabath, M. B., Schleutker, J., Schmidt, M. K., Setiawan, V. W., Shen, H., Siegel, E. M., Sieh, W., Singer, C. F., Slattery, M. L., Sorensen, K. D., Southey, M. C., Spurdle, A. B., Stanford, J. L., Stevens, V. L., Stintzing, S., Stone, J., Sundfeldt, K., Sutphen, R., Swerdlow, A. J., Tajara, E. H., Tangen, C. M., Tardon, A., Taylor, J. A., Teare, M. D., Teixeira, M. R., Terry, M. B., Terry, K. L., Thibodeau, S. N., Thomassen, M., Bjorge, L., Tischkowitz, M., Toland, A. E., Torres, D., Townsend, P. A., Travis, R. C., Tung, N., Tworoger, S. S., Ulrich, C. M., Usmani, N., Vachon, C. M., Van Nieuwenhuysen, E., Vega, A., Aguado-Barrera, M. E., Wang, Q., Webb, P. M., Weinberg, C. R., Weinstein, S., Weissler, M. C., Weitzel, J. N., West, C. M. L., White, E., Whittemore, A. S., Wichmann, H. -E., Wiklund, F., Winqvist, R., Wolk, A., Woll, P., Woods, M., Wu, A. H., Wu, X., Yannoukakos, D., Zheng, W., Zienolddiny, S., Ziogas, A., Zorn, K. K., Lane, J. M., Saxena, R., Thomas, D., Hung, R. J., Diergaarde, B., McKay, J., Peters, U., Hsu, L., Garcia-Closas, M., Eeles, R. A., Chenevix-Trench, G., Brennan, P. J., Haiman, C. A., Simard, J., Easton, D. F., Gruber, S. B., Pharoah, P. D. P., Price, A. L., Pasaniuc, B., Amos, C. I., Kraft, P., Lindstrom, S., Boccia S. (ORCID:0000-0002-1864-749X), Cadoni G. (ORCID:0000-0001-8244-784X), Chen C., Liu G., and Wang Q.
Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Published: 2019

16. Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations

Author: van Duijnhoven, F. J. B., Jenab, M., Hveem, K., Siersema, P. D., Fedirko, V., Duell, E. J., Kampman, E., Halfweeg, A., van Kranen, H. J., van den Ouweland, J. M. W., Weiderpass, E., Langhammer, A., Ness-Jensen, E., Olsen, A., Tjonneland, A., Overvad, K., Cadeau, C., Kvaskoff, M., Boutron-Ruault, M. C., Katzke, V. A., Kuhn, T., Boeing, H., Trichopoulou, A., Kotanidou, A., Kritikou, M., Palli, D., Agnoli, C., Tumino, R., Panico, S., Matullo, G., Peeters, P., Brustad, M., Olsen, K. S., Lasheras, C., Obon-Santacana, M., Sanchez, M. J., Dorronsoro, M., Chirlaque, M. D., Barricarte, A., Manjer, J., Almquist, M., Renstrom, F., Ye, W., Wareham, N., Khaw, K. T., Bradbury, K. E., Freisling, H., Aune, D., Norat, T., Riboli, E., and Bueno-de-Mesquita, H. B. A.
Subjects: SDG 3 - Good Health and Well-being
Abstract: Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre‐diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case‐control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord‐Trøndelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow‐up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope‐dilution liquid chromatography‐tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42–1.20); 0.94 (0.72–1.22); 1.12 (0.82–1.53) and 1.26 (0.79–2.01) for clinically pre‐defined categories of ≤25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season‐standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre‐diagnostic concentrations of vitamin D, they are not statistically significant.
Published: 2018

17. Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

Author: Matejcic, M. Lesueur, F. Biessy, C. Renault, A. L. and Mebirouk, N. Yammine, S. Keski-Rahkonen, P. Li, K. and Hemon, B. Weiderpass, E. Rebours, V. Boutron-Ruault, M. C. and Carbonnel, F. Kaaks, R. Katzke, V. Kuhn, T. Boeing, H. Trichopoulou, A. Palli, D. Agnoli, C. Panico, S. and Tumino, R. Sacerdote, C. Quiros, J. R. Duell, E. J. and Porta, M. Sanchez, M. J. Chirlaque, M. D. Barricarte, A. and Amiano, P. Ye, W. Peeters, P. H. Khaw, K. T. and Perez-Cornago, A. Key, T. J. Bueno-de-Mesquita, H. B. and Riboli, E. Vineis, P. Romieu, I. Gunter, M. J. Chajes, V.
Abstract: There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from375 incident pancreatic cancer cases and375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (ORT3-T1[odds ratio for highest versus lowest tertile] =0.63; 95%CI[confidence interval] = 0.41-0.98; p(trend) = 0.036), n-3 polyunsaturated -linolenic acid (ORT3-T1 = 0.60; 95%CI = 0.39-0.92; p(trend) = 0.02) and docosapentaenoic acid (ORT3-T1 = 0.52; 95%CI = 0.32-0.85; p(trend) = 0.008). Industrial trans-fatty acids were positively associated with pancreatic cancer risk among men (ORT3-T1 = 3.00; 95%CI = 1.13-7.99; p(trend) = 0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (ORT3-T1 = 0.37; 95%CI = 0.17-0.81; p(trend) = 0.008). Among current smokers, the long-chain n-6/n-3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (ORT3-T1 = 3.40; 95%CI = 1.39-8.34; p(trend) = 0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n-3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex-specific and modulated by smoking.
Published: 2018

18. Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

Author: Matejcic, M., Lesueur, F., Biessy, C., Renault, A. L., Mebirouk, N., Yammine, S., Keski-Rahkonen, P., Li, K., Hemon, B., Weiderpass, E., Rebours, V., Boutron-Ruault, M. C., Carbonnel, F., Kaaks, R., Katzke, V., Kuhn, T., Boeing, H., Trichopoulou, A., Palli, D., Agnoli, C., Panico, S., Tumino, R., Sacerdote, C., Quiros, J. R., Duell, E. J., Porta, M., Sanchez, M. J., Chirlaque, M. D., Barricarte, A., Amiano, P., Ye, Weimin, Peeters, P. H., Khaw, K. T., Perez-Cornago, A., Key, T. J., Bueno-de-Mesquita, H. B., Riboli, E., Vineis, P., Romieu, I., Gunter, M. J., Chajes, V., Matejcic, M., Lesueur, F., Biessy, C., Renault, A. L., Mebirouk, N., Yammine, S., Keski-Rahkonen, P., Li, K., Hemon, B., Weiderpass, E., Rebours, V., Boutron-Ruault, M. C., Carbonnel, F., Kaaks, R., Katzke, V., Kuhn, T., Boeing, H., Trichopoulou, A., Palli, D., Agnoli, C., Panico, S., Tumino, R., Sacerdote, C., Quiros, J. R., Duell, E. J., Porta, M., Sanchez, M. J., Chirlaque, M. D., Barricarte, A., Amiano, P., Ye, Weimin, Peeters, P. H., Khaw, K. T., Perez-Cornago, A., Key, T. J., Bueno-de-Mesquita, H. B., Riboli, E., Vineis, P., Romieu, I., Gunter, M. J., and Chajes, V.
Abstract: There are both limited and conflicting data on the role of dietary fat and specific fatty acids in the development of pancreatic cancer. In this study, we investigated the association between plasma phospholipid fatty acids and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The fatty acid composition was measured by gas chromatography in plasma samples collected at recruitment from375 incident pancreatic cancer cases and375 matched controls. Associations of specific fatty acids with pancreatic cancer risk were evaluated using multivariable conditional logistic regression models with adjustment for established pancreatic cancer risk factors. Statistically significant inverse associations were found between pancreatic cancer incidence and levels of heptadecanoic acid (ORT3‐T1[odds ratio for highest versus lowest tertile] =0.63; 95%CI[confidence interval] = 0.41–0.98; ptrend = 0.036), n‐3 polyunsaturated α‐linolenic acid (ORT3‐T1 = 0.60; 95%CI = 0.39–0.92; ptrend = 0.02) and docosapentaenoic acid (ORT3‐T1 = 0.52; 95%CI = 0.32–0.85; ptrend = 0.008). Industrial trans‐fatty acids were positively associated with pancreatic cancer risk among men (ORT3‐T1 = 3.00; 95%CI = 1.13–7.99; ptrend = 0.029), while conjugated linoleic acids were inversely related to pancreatic cancer among women only (ORT3‐T1 = 0.37; 95%CI = 0.17–0.81; ptrend = 0.008). Among current smokers, the long‐chain n‐6/n‐3 polyunsaturated fatty acids ratio was positively associated with pancreatic cancer risk (ORT3‐T1 = 3.40; 95%CI = 1.39–8.34; ptrend = 0.007). Results were robust to a range of sensitivity analyses. Our findings suggest that higher circulating levels of saturated fatty acids with an odd number of carbon atoms and n‐3 polyunsaturated fatty acids may be related to lower risk of pancreatic cancer. The influence of some fatty acids on the development of pancreatic cancer may be sex‐specific and modulated by smoking.
Published: 2018
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19. Circulating plasma phospholipid fatty acids and risk of pancreatic cancer in a large European cohort

Author: JC onderzoeksprogramma Kanker, Cancer, Epi Kanker Team B, UMC Utrecht, Matejcic, M., Lesueur, F., Biessy, C., Renault, A. L., Mebirouk, N., Yammine, S., Keski-Rahkonen, P., Li, K., Hémon, B., Weiderpass, E., Rebours, V., Boutron-Ruault, M. C., Carbonnel, F., Kaaks, R., Katzke, V., Kuhn, T., Boeing, H., Trichopoulou, A., Palli, D., Agnoli, C., Panico, S., Tumino, R., Sacerdote, C., Quirós, J. R., Duell, E. J., Porta, M., Sánchez, M. J., Chirlaque, M. D., Barricarte, A., Amiano, P., Ye, W., Peeters, P. H., Khaw, K. T., Perez-Cornago, A., Key, T. J., Bueno-de-Mesquita, H. B., Riboli, E., Vineis, P., Romieu, I., Gunter, M. J., Chajès, V., JC onderzoeksprogramma Kanker, Cancer, Epi Kanker Team B, UMC Utrecht, Matejcic, M., Lesueur, F., Biessy, C., Renault, A. L., Mebirouk, N., Yammine, S., Keski-Rahkonen, P., Li, K., Hémon, B., Weiderpass, E., Rebours, V., Boutron-Ruault, M. C., Carbonnel, F., Kaaks, R., Katzke, V., Kuhn, T., Boeing, H., Trichopoulou, A., Palli, D., Agnoli, C., Panico, S., Tumino, R., Sacerdote, C., Quirós, J. R., Duell, E. J., Porta, M., Sánchez, M. J., Chirlaque, M. D., Barricarte, A., Amiano, P., Ye, W., Peeters, P. H., Khaw, K. T., Perez-Cornago, A., Key, T. J., Bueno-de-Mesquita, H. B., Riboli, E., Vineis, P., Romieu, I., Gunter, M. J., and Chajès, V.
Published: 2018

20. Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study

Author: Fehringer, G., Brenner, D. R., Zhang, Z. -F., Lee, Y. -C. A., Matsuo, K., Ito, H., Lan, Q., Vineis, P., Johansson, M., Overvad, K., Riboli, E., Trichopoulou, A., Sacerdote, C., Stucker, I., Boffetta, P., Brennan, P., Christiani, D. C., Hong, Y. -C., L, i, M. T., Morgenstern, H., Schwartz, A. G., Wenzlaff, A. S., Rennert, G., McLaughlin, J. R., Harris, C. C., Olivo-Marston, S., Orlow, I., Park, B. J., Zauderer, M., Barros Dios, J. M., Ruano Raviña, A., Siemiatycki, J., Koushik, A., Lazarus, P., Fernández-Somoano, A., Tardon, A., Le March, Brenner, H., Saum, K. -U., Duell, E. J., Andrew, A. S., Szeszenia-Dabrowska, N., Lissowska, J., Zaridze, D., Rudnai, P., Fabianova, E., Mates, D., Foretova, L., Janout, V., Bencko, V., Holcatova, I., Pesatori, A. C., Consonni, D., Olsson, A., Straif, K., Hung, R. J., and Fehringer, G. and Brenner, D.R. and Zhang, Z.-F. and Lee, Y.-C.A. and Matsuo, K. and Ito, H. and Lan, Q. and Vineis, P. and Johansson, M. and Overvad, K. and Riboli, E. and Trichopoulou, A. and Sacerdote, C. and Stucker, I. and Boffetta, P. and Brennan, P. and Christiani, D.C. and Hong, Y.-C. and Landi, M.T. and Morgenstern, H. and Schwartz, A.G. and Wenzlaff, A.S. and Rennert, G. and McLaughlin, J.R. and Harris, C.C. and Olivo-Marston, S. and Orlow, I. and Park, B.J. and Zauderer, M. and Barros Dios, J.M. and Ruano Raviña, A. and Siemiatycki, J. and Koushik, A. and Lazarus, P. and Fernández-Somoano, A. and Tardon, A. and Le Marchand, L. and Brenner, H. and Saum, K.-U. and Duell, E.J. and Andrew, A.S. and Szeszenia-Dabrowska, N. and Lissowska, J. and Zaridze, D. and Rudnai, P. and Fabianova, E. and Mates, D. and Foretova, L. and Janout, V. and Bencko, V. and Holcatova, I. and Pesatori, A.C. and Consonni, D. and Olsson, A. and Straif, K. and Hung, R.J.
Subjects: Male, Asia, Alcohol Drinking, alcohol consumption, sex difference, cohort analysi, environmental exposure, cancer risk, high risk patient, Article, smoking, liquor, adverse effect, middle aged, controlled study, smoking, Aged, human, Alcoholic Beverage, wine, risk reduction, alcohol, adult, Risk Factor, disease association, drinking behavior, occupational exposure, case control study, lung adenocarcinoma, major clinical study, Europe, Lung Neoplasm, aged, lung cancer, female, North America, pathology, beer, small cell lung cancer, Cohort Studie, Case-Control Studie, squamous cell lung carcinoma
Abstract: It is not clear whether alcohol consumption is associated with lung cancer risk. The relationship is likely confounded by smoking, complicating the interpretation of previous studies. We examined the association of alcohol consumption and lung cancer risk in a large pooled international sample, minimizing potential confounding of tobacco consumption by restricting analyses to never smokers. Our study included 22 case-control and cohort studies with a total of 2548 never-smoking lung cancer patients and 9362 never-smoking controls from North America, Europe and Asia within the International Lung Cancer Consortium (ILCCO) and SYNERGY Consortium. Alcohol consumption was categorized into amounts consumed (grams per day) and also modelled as a continuous variable using restricted cubic splines for potential non-linearity. Analyses by histologic sub-type were included. Associations by type of alcohol consumed (wine, beer and liquor) were also investigated. Alcohol consumption was inversely associated with lung cancer risk with evidence most strongly supporting lower risk for light and moderate drinkers relative to non-drinkers (>0–4.9 g per day: OR = 0.80, 95% CI = 0.70–0.90; 5–9.9 g per day: OR = 0.82, 95% CI = 0.69–0.99; 10–19.9 g per day: OR = 0.79, 95% CI = 0.65–0.96). Inverse associations were found for consumption of wine and liquor, but not beer. The results indicate that alcohol consumption is inversely associated with lung cancer risk, particularly among subjects with low to moderate consumption levels, and among wine and liquor drinkers, but not beer drinkers. Although our results should have no relevant bias from the confounding effect of smoking we cannot preclude that confounding by other factors contributed to the observed associations. Confounding in relation to the non-drinker reference category may be of particular importance. © 2017 UICC
Published: 2017

21. Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S

Author: Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., Scelo, G., Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., and Scelo, G.
Published: 2017

22. Alcohol consumption and the risk of renal cancers in the European Prospective Investigation into Cancer and Nutrition (EPIC). Wozniak MB, Brennan P, Brenner DR, Overvad K, Olsen A, Tjønneland A, Boutron-Ruault MC, Clavel-Chapelon F, Fagherazzi G, Katzke V, Kühn T, Boeing H, Bergmann MM, Steffen A, Naska A, Trichopoulou A, Trichopoulos D, Saieva C, Grioni S, Panico S, Tumino R, Vineis P, Bueno-de-Mesquita HB, Peeters PH, Hjartåker A, Weiderpass E, Arriola L, Molina-Montes E, Duell EJ, Santiuste C, Alonso de la Torre R, Barricarte Gurrea A, Stocks T, Johansson M, Ljungberg B, Wareham N, Khaw KT, Travis RC, Cross AJ, Murphy N, Riboli E, Scelo G.Int J Cancer. 2015 Oct 15;137(8):1953-66. [Epub 2015 Apr 28]. doi

Author: MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., Scelo, G., MS MDL 1, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Jay, Raman, Brennan, P., Brenner, X., Overvad, K., Olsen, A., Tjønneland, A., Boutron-Ruault, M. C., Clavel-Chapelon, F., Fagherazzi, X., Katzke, V., Kühn, T., Boeing, H., Bergmann, M. M., Steffen, A., Naska, A., Trichopoulou, A., Trichopoulos, D., Saieva, C., Grioni, S., Panico, S., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Hjartåker, A., Peeters, P. H., Weiderpass, E., Arriola, L., Molina-Montes, E., Duell, E. J., Santiuste, C., Alonso de la Torre, R., Barricarte Gurrea, A., Stocks, T., Johansson, M., Ljungberg, B., Wareham, N., Khaw, K. T., Travis, R. C., Cross, A. J., Murphy, N., Riboli, E., and Scelo, G.
Published: 2017

23. Flavonoid and lignan intake and pancreatic cancer risk in the European prospective investigation into cancer and nutrition cohort

Author: Molina-Montes, E., Sanchez, M. J., Zamora-Ros, R., Bueno-de-Mesquita, H. B., Wark, P. A., Obon-Santacana, M., Kuhn, T., Katzke, V., Travis, R. C., Ye, W., Sund, M., Naccarati, A., Mattiello, A., Krogh, V., Martorana, C., Masala, G., Amiano, P., Huerta, J. M., Barricarte, A., Quiros, J. R., Weiderpass, E., Angell Asli, L., Skeie, G., Ericson, U., Sonestedt, E., Peeters, P. H., Romieu, I., Scalbert, A., Overvad, K., Clemens, M., Boeing, H., Trichopoulou, A., Peppa, E., Vidalis, P., Khaw, K. T., Wareham, N., Olsen, A., Tjonneland, A., Boutroun-Rualt, M. C., Clavel-Chapelon, F., Cross, A. J., Riboli, E., and Duell, E. J.
Subjects: SDG 3 - Good Health and Well-being
Abstract: Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between dietary intakes of flavonoids and lignans and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 865 exocrine pancreatic cancer cases occurred after 11.3 years of follow-up of 477,309 cohort members. Dietary flavonoid and lignan intake was estimated through validated dietary questionnaires and the US Department of Agriculture (USDA) and Phenol Explorer databases. Hazard ratios (HR) and 95% confidence intervals (CIs) were calculated using age, sex and center-stratified Cox proportional hazards models, adjusted for energy intake, body mass index (BMI), smoking, alcohol and diabetes status. Our results showed that neither overall dietary intake of flavonoids nor of lignans were associated with pancreatic cancer risk (multivariable-adjusted HR for a doubling of intake 5 1.03, 95% CI: 0.95–1.11 and 1.02; 95% CI: 0.89– 1.17, respectively). Statistically significant associations were also not observed by flavonoid subclasses. An inverse association between intake of flavanones and pancreatic cancer risk was apparent, without reaching statistical significance, in microscopically confirmed cases (HR for a doubling of intake 5 0.96, 95% CI: 0.91–1.00). In conclusion, we did not observe an association between intake of flavonoids, flavonoid subclasses or lignans and pancreatic cancer risk in the EPIC cohort.
Published: 2016

24. Common colorectal cancer risk alleles contribute to the multiple colorectal adenoma phenotype, but do not influence colonic polyposis in FAP

Author: Cheng, T. H. T., Gorman, M., Martin, L., Barclay, E., Casey, G., Newcomb, P. A., Conti, D. V., Schumacher, F. R., Gallinger, S., Lindor, N. M., Hopper, J., Jenkins, M., Hunter, D. J., Kraft, P., Jacobs, K. B., Cox, D. G., Yeager, M., Hankinson, S. E., Wacholder, S., Wang, Z., Welch, R., Hutchinson, A., Wang, J., Yu, K., Chatterjee, N., Orr, N., Willett, W. C., Colditz, G. A., Ziegler, R. G., Berg, C. D., Buys, S. S., McCarty, C. A., Feigelson, H. S., Calle, E. E., Thun, M. J., Hayes, R. B., Tucker, M., Gerhard, D. S., Fraumeni, J. F., Jr., Hoover, R. N., Thomas, G., Chanock, S. J., Ciampa, J., Gonzalez-Bosquet, J., Berndt, S., Amundadottir, L., Diver, W. R., Albanes, D., Virtamo, J., Weinstein, S. J., Cancel-Tassin, G., Cussenot, O., Valeri, A., Andriole, G. L., Crawford, E. D., Haiman, C. A., Henderson, B., Kolonel, L., March, L. L., Siddiq, A., Riboli, E., Key, T. J., Kaaks, R., Isaacs, W., Isaacs, S., Wiley, K. E., Gronberg, H., Wiklund, F., Stattin, P., Xu, J., Zheng, S. L., Sun, J., Vatten, L. J., Hveem, K., Kumle, M., Purdue, M. P., Johansson, M., Zelenika, D., Toro, J. R., Scelo, G., Moore, L. E., Prokhortchouk, E., Wu, X., Kiemeney, L. A., Gaborieau, V., Chow, W. -H., Zaridze, D., Matveev, V., Lubinski, J., Trubicka, J., Szeszenia-Dabrowska, N., Lissowska, J., Rudnai, P., Fabianova, E., Bucur, A., Bencko, V., Foretova, L., Janout, V., Boffetta, P., Colt, J. S., Davis, F. G., Schwartz, K. L., Banks, R. E., Selby, P. J., Harnden, P., Hsing, A. W., Grubb, R. L., III, Boeing, H., Vineis, P., Clavel-Chapelon, F., Palli, D., Tumino, R., Krogh, V., Panico, S., Duell, E. J., Quirós, J. R., Sanchez, M. -J., Navarro, C., Ardanaz, E., Dorronsoro, M., Khaw, K. -T., Allen, N. E., Bueno-de-Mesquita, H. B., Peeters, P. H. M., Trichopoulos, D., Linseisen, J., Ljungberg, B., Overvad, K., Tjønnel, Romieu, I., Mukeria, A., Shangina, O., Stevens, V. L., Gapstur, S. M., Pharoah, P. D., Easton, D. F., Njølstad, I., Tell, G. S., Stoltenberg, C., Kumar, R., Koppova, K., Benhamou, S., Oosterwijk, E., Vermeulen, S. H., Aben, K. K. H., Van Der Marel, S. L., Ye, Y., Wood, C. G., Pu, X., Mazur, A. M., Boulygina, E. S., Chekanov, N. N., Foglio, M., Lechner, D., Gut, I., Heath, S., Blanche, H., Skryabin, K. G., McKay, J. D., Rothman, N., Lathrop, M., Brennan, P., Saunders, B., Thomas, H., Clark, S., Tomlinson, I., and Cheng, T.H.T. and Gorman, M. and Martin, L. and Barclay, E. and Casey, G. and Newcomb, P.A. and Conti, D.V. and Schumacher, F.R. and Gallinger, S. and Lindor, N.M. and Hopper, J. and Jenkins, M. and Hunter, D.J. and Kraft, P. and Jacobs, K.B. and Cox, D.G. and Yeager, M. and Hankinson, S.E. and Wacholder, S. and Wang, Z. and Welch, R. and Hutchinson, A. and Wang, J. and Yu, K. and Chatterjee, N. and Orr, N. and Willett, W.C. and Colditz, G.A. and Ziegler, R.G. and Berg, C.D. and Buys, S.S. and McCarty, C.A. and Feigelson, H.S. and Calle, E.E. and Thun, M.J. and Hayes, R.B. and Tucker, M. and Gerhard, D.S. and Fraumeni, J.F., Jr. and Hoover, R.N. and Thomas, G. and Chanock, S.J. and Ciampa, J. and Gonzalez-Bosquet, J. and Berndt, S. and Amundadottir, L. and Diver, W.R. and Albanes, D. and Virtamo, J. and Weinstein, S.J. and Cancel-Tassin, G. and Cussenot, O. and Valeri, A. and Andriole, G.L. and Crawford, E.D. and Haiman, C.A. and Henderson, B. and Kolonel, L. and Marchand, L.L. and Siddiq, A. and Riboli, E. and Key, T.J. and Kaaks, R. and Isaacs, W. and Isaacs, S. and Wiley, K.E. and Gronberg, H. and Wiklund, F. and Stattin, P. and Xu, J. and Zheng, S.L. and Sun, J. and Vatten, L.J. and Hveem, K. and Kumle, M. and Purdue, M.P. and Johansson, M. and Zelenika, D. and Toro, J.R. and Scelo, G. and Moore, L.E. and Prokhortchouk, E. and Wu, X. and Kiemeney, L.A. and Gaborieau, V. and Chow, W.-H. and Zaridze, D. and Matveev, V. and Lubinski, J. and Trubicka, J. and Szeszenia-Dabrowska, N. and Lissowska, J. and Rudnai, P. and Fabianova, E. and Bucur, A. and Bencko, V. and Foretova, L. and Janout, V. and Boffetta, P. and Colt, J.S. and Davis, F.G. and Schwartz, K.L. and Banks, R.E. and Selby, P.J. and Harnden, P. and Hsing, A.W. and Grubb, R.L., III and Boeing, H. and Vineis, P. and Clavel-Chapelon, F. and Palli, D. and Tumino, R. and Krogh, V. and Panico, S. and Duell, E.J. and Quirós, J.R. and Sanchez, M.-J. and Navarro, C. and Ardanaz, E. and Dorronsoro, M. and Khaw, K.-T. and Allen, N.E. and Bueno-de-Mesquita, H.B. and Peeters, P.H.M. and Trichopoulos, D. and Linseisen, J. and Ljungberg, B. and Overvad, K. and Tjønneland, A. and Romieu, I. and Mukeria, A. and Shangina, O. and Stevens, V.L. and Gapstur, S.M. and Pharoah, P.D. and Easton, D.F. and Njølstad, I. and Tell, G.S. and Stoltenberg, C. and Kumar, R. and Koppova, K. and Benhamou, S. and Oosterwijk, E. and Vermeulen, S.H. and Aben, K.K.H. and Van Der Marel, S.L. and Ye, Y. and Wood, C.G. and Pu, X. and Mazur, A.M. and Boulygina, E.S. and Chekanov, N.N. and Foglio, M. and Lechner, D. and Gut, I. and Heath, S. and Blanche, H. and Skryabin, K.G. and McKay, J.D. and Rothman, N. and Lathrop, M. and Brennan, P. and Saunders, B. and Thomas, H. and Clark, S. and Tomlinson, I.
Subjects: Male, pathogenesi, genetic association, phenotype, Adenomatous Polyposis Coli Protein, colorectal cancer, Colorectal Neoplasm, cancer risk, gene frequency, Polymorphism, Single Nucleotide, Article, DNA glycosyltransferase, adult, DNA glycosylase MutY, colon polyposi, single nucleotide polymorphism, genetic variability, middle aged, controlled study, Genetic Predisposition to Disease, human, DNA Glycosylase, Germ-Line Mutation, Aged, colorectal adenoma, Allele, modifier gene, Genes, Modifier, disease predisposition, APC protein, human, major clinical study, digestive system diseases, human tissue, APC protein, female, priority journal, Adenomatous Polyposis Coli, germline mutation, familial colon polyposi, adenoma, single nucleotide polymorphism, Adenoma, genetic, genetic predisposition
Abstract: The presence of multiple (5-100) colorectal adenomas suggests an inherited predisposition, but the genetic aetiology of this phenotype is undetermined if patients test negative for Mendelian polyposis syndromes such as familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP). We investigated whether 18 common colorectal cancer (CRC) predisposition single-nucleotide polymorphisms (SNPs) could help to explain some cases with multiple adenomas who phenocopied FAP or MAP, but had no pathogenic APC or MUTYH variant. No multiple adenoma case had an outlying number of CRC SNP risk alleles, but multiple adenoma patients did have a significantly higher number of risk alleles than population controls (P = 5.7 × 10-7). The association was stronger in those with ≥ 10 adenomas. The CRC SNPs accounted for 4.3% of the variation in multiple adenoma risk, with three SNPs (rs6983267, rs10795668, rs3802842) explaining 3.0% of the variation. In FAP patients, the CRC risk score did not differ significantly from the controls, as we expected given the overwhelming effect of pathogenic germline APC variants on the phenotype of these cases. More unexpectedly, we found no evidence that the CRC SNPs act as modifier genes for the number of colorectal adenomas in FAP patients. In conclusion, common colorectal tumour risk alleles contribute to the development of multiple adenomas in patients without pathogenic germline APC or MUTYH variants. This phenotype may have 'polygenic' or monogenic origins. The risk of CRC in relatives of multiple adenoma cases is probably much lower for cases with polygenic disease, and this should be taken into account when counselling such patients. © 2015 Macmillan Publishers Limited All rights reserved.
Published: 2015

25. A meta-analysis of Hodgkin lymphoma reveals 19p13.3 TCF3 as a novel susceptibility locus

Author: Cozen, W., Timofeeva, M. N., Diepstra, A., Hazelett, D., Delahaye-Sourdeix, M., Edlund, C. K., Franke, L., Rostgaard, K., Van Den Berg, D. J., Cortessis, V. K., Smedby, K. E., Glaser, S. L., Westra, H. J., Robison, L. L., Mack, T. M., Ghesquieres, H., Hwang, A. E., Nieters, A., De Sanjose, S., Lightfoot, T., Becker, N., Maynadie, M., Foretova, L., Roman, E., Benavente, Y., Rand, K. A., Nathwani, B. N., Glimelius, B., Staines, A., Boffetta, P., Link, B. K., Kiemeney, L., Ansell, S. M., Bhatia, S., Strong, L. C., Galan, P., Vatten, L., Habermann, T. M., Duell, E. J., Lake, A., Veenstra, R. N., Visser, L., Liu, Y., Urayama, K. Y., Montgomery, D., Gaborieau, V., Weiss, L. M., Byrnes, G., Lathrop, M., Cocco, P., Best, T., Skol, A. D., Adami, H. O., Melbye, M., Cerhan, J. R., Gallagher, A., Taylor, G. M., Slager, S. L., Brennan, P., Coetzee, G. A., Conti, D. V., Onel, K., Jarrett, R. F., Hjalgrim, H., Van Den Berg, A., and McKay, J. D.
Abstract: Recent genome-wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio (OR)=0.81, 95% confidence interval (95% CI)=0.76-0.86, P combined =3.5 × 10 10), located in intron 2 of TCF3 (also known as E2A), a regulator of B-and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16, 5q31, 6p31, 8q24 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk.
Published: 2014

26. Exposure to secondhand tobacco smoke and lung cancer by histological type: a pooled analysis of the International Lung Cancer Consortium (ILCCO)

Author: Kim, C. H., Lee, Y. -C. A., Hung, R. J., McNallan, S. R., Cote, M. L., Lim, W. -Y., Chang, S. -C., Kim, J. H., Ugolini, D., Chen, Y., Liloglou, T., Andrew, A. S., Onega, T., Duell, E. J., Field, J. K., Lazarus, P., Le Marchand, L., Neri, M., Vineis, P., Kiyohara, C., Hong, Y. -C., Morgenstern, H., Matsuo, K., Tajima, K., Christiani, D. C., McLaughlin, J. R., Bencko, V., Holcatova, I., Boffetta, P., Brennan, P., Fabianova, E., Foretova, L., Janout, V., Lissowska, J., Mates, D., Rudnai, P., Szeszenia-Dabrowska, N., Mukeria, A., Zaridze, D., Seow, A., Schwartz, A. G., Yang, P., Zhang, Z. -F., Kim, C.H., Lee, Y.-C.A., Hung, R.J., McNallan, S.R., Cote, M.L., Lim, W.-Y., Chang, S.-C., Kim, J.H., Ugolini, D., Chen, Y., Liloglou, T., Andrew, A.S., Onega, T., Duell, E.J., Field, J.K., Lazarus, P., Le Marchand, L., Neri, M., Vineis, P., Kiyohara, C., Hong, Y.-C., Morgenstern, H., Matsuo, K., Tajima, K., Christiani, D.C., McLaughlin, J.R., Bencko, V., Holcatova, I., Boffetta, P., Brennan, P., Fabianova, E., Foretova, L., Janout, V., Lissowska, J., Mates, D., Rudnai, P., Szeszenia-Dabrowska, N., Mukeria, A., Zaridze, D., Seow, A., Schwartz, A.G., Yang, P., and Zhang, Z.-F.
Subjects: Lung Neoplasms, International Lung Cancer Consortium, environmental tobacco smoke, Environmental Exposure, lung cancer, Secondhand tobacco smoke, Adenocarcinoma, Small Cell Lung Carcinoma, Article, Risk Factors, involuntary smoking, Carcinoma, Non-Small-Cell Lung, Case-Control Studies, Carcinoma, Squamous Cell, Humans, Tobacco Smoke Pollution, secondhand smoke
Abstract: While the association between exposure to secondhand smoke and lung cancer risk is well established, few studies with sufficient power have examined the association by histological type. In this study, we evaluated the secondhand smoke-lung cancer relationship by histological type based on pooled data from 18 case-control studies in the International Lung Cancer Consortium (ILCCO), including 2,504 cases and 7,276 control who were never smokers and 10,184 cases and 7,176 controls who were ever smokers. We used multivariable logistic regression, adjusting for age, sex, race/ethnicity, smoking status, pack-years of smoking, and study. Among never smokers, the odds ratios (OR) comparing those ever exposed to secondhand smoke with those never exposed were 1.31 (95% CI: 1.17-1.45) for all histological types combined, 1.26 (95% CI: 1.10-1.44) for adenocarcinoma, 1.41 (95% CI: 0.99-1.99) for squamous cell carcinoma, 1.48 (95% CI: 0.89-2.45) for large cell lung cancer, and 3.09 (95% CI: 1.62-5.89) for small cell lung cancer. The estimated association with secondhand smoke exposure was greater for small cell lung cancer than for nonsmall cell lung cancers (OR=2.11, 95% CI: 1.11-4.04). This analysis is the largest to date investigating the relation between exposure to secondhand smoke and lung cancer. Our study provides more precise estimates of the impact of secondhand smoke on the major histological types of lung cancer, indicates the association with secondhand smoke is stronger for small cell lung cancer than for the other histological types, and suggests the importance of intervention against exposure to secondhand smoke in lung cancer prevention. © 2014 UICC.
Published: 2014

27. Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Author: Obon-Santacana, M. Kaaks, R. Slimani, N. Lujan-Barroso, L. and Freisling, H. Ferrari, P. Dossus, L. Chabbert-Buffet, N. and Baglietto, L. Fortner, R. T. Boeing, H. Tjonneland, A. and Olsen, A. Overvad, K. Menendez, V. Molina-Montes, E. and Larranaga, N. Chirlaque, M-D Ardanaz, E. Khaw, K-T and Wareham, N. Travis, R. C. Lu, Y. Merritt, M. A. and Trichopoulou, A. Benetou, V. Trichopoulos, D. Saieva, C. and Sieri, S. Tumino, R. Sacerdote, C. Galasso, R. and Bueno-de-Mesquita, H. B. Wirfalt, E. Ericson, U. Idahl, A. and Ohlson, N. Skeie, G. Gram, I. T. Weiderpass, E. and Onland-Moret, N. C. Riboli, E. Duell, E. J.
Abstract: Background: Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk. Methods: Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method. Results: No associations were observed between acrylamide intake and overall EC (n = 1382) or type-I EC risk (n = 627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n = 203). Conclusions: Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.
Published: 2014

28. An epidemiologic risk prediction model for ovarian cancer in Europe : the EPIC study

Author: Li, K., Huesing, A., Fortner, R. T., Tjonneland, A., Hansen, L., Dossus, L., Chang-Claude, J., Bergmann, M., Steffen, A., Bamia, C., Trichopoulos, D., Trichopoulou, A., Palli, D., Mattiello, A., Agnoli, C., Tumino, R., Onland-Moret, N. C., Peeters, P. H., Bueno-de-Mesquita, H. B(as), Gram, I. T., Weiderpass, E., Sanchez-Cantalejo, E., Chirlaque, M-D, Duell, E. J., Ardanaz, E., Idahl, Annika, Lundin, E., Khaw, K-T, Travis, R. C., Merritt, M. A., Gunter, M. J., Riboli, E., Ferrari, P., Terry, K., Cramer, D., Kaaks, R., Li, K., Huesing, A., Fortner, R. T., Tjonneland, A., Hansen, L., Dossus, L., Chang-Claude, J., Bergmann, M., Steffen, A., Bamia, C., Trichopoulos, D., Trichopoulou, A., Palli, D., Mattiello, A., Agnoli, C., Tumino, R., Onland-Moret, N. C., Peeters, P. H., Bueno-de-Mesquita, H. B(as), Gram, I. T., Weiderpass, E., Sanchez-Cantalejo, E., Chirlaque, M-D, Duell, E. J., Ardanaz, E., Idahl, Annika, Lundin, E., Khaw, K-T, Travis, R. C., Merritt, M. A., Gunter, M. J., Riboli, E., Ferrari, P., Terry, K., Cramer, D., and Kaaks, R.
Abstract: Background: Ovarian cancer has a high case-fatality ratio, largely due to late diagnosis. Epidemiologic risk prediction models could help identify women at increased risk who may benefit from targeted prevention measures, such as screening or chemopreventive agents. Methods: We built an ovarian cancer risk prediction model with epidemiologic risk factors from 202 206 women in the European Prospective Investigation into Cancer and Nutrition study. Results: Older age at menopause, longer duration of hormone replacement therapy, and higher body mass index were included as increasing ovarian cancer risk, whereas unilateral ovariectomy, longer duration of oral contraceptive use, and higher number of full-term pregnancies were decreasing risk. The discriminatory power (overall concordance index) of this model, as examined with five-fold cross-validation, was 0.64 (95% confidence interval (CI): 0.57, 0.70). The ratio of the expected to observed number of ovarian cancer cases occurring in the first 5 years of follow-up was 0.90 (293 out of 324, 95% CI: 0.81-1.01), in general there was no evidence for miscalibration. Conclusion: Our ovarian cancer risk model containing only epidemiological data showed modest discriminatory power for a Western European population. Future studies should consider adding informative biomarkers to possibly improve the predictive ability of the model.
Published: 2015
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29. Diabetes and Onset of Natural Menopause : Results From the European Prospective Investigation Into Cancer and Nutrition EDITORIAL COMMENT

Author: Brand, J. S., Onland-Moret, N. C., Eijkemans, M. J. C., Tjonneland, A., Roswall, N., Overvad, K., Fagherazzi, G., Clavel-Chapelon, F., Dossus, L., Lukanova, Annekatrin, Grote, V., Bergmann, M. M., Boeing, H., Trichopoulou, A., Tzivoglou, M., Trichopoulos, D., Grioni, S., Mattiello, A., Masala, G., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Weiderpass, E., Redondo, M. L., Sanchez, M. J., Castano, J. M. Huerta, Arriola, L., Ardanaz, E., Duell, E. J., Rolandsson, O., Franks, P. W., Butt, S., Nilsson, P., Khaw, K. T., Wareham, N., Travis, R., Romieu, I., Gunter, M. J., Riboli, E., van der Schouw, Y. T., Brand, J. S., Onland-Moret, N. C., Eijkemans, M. J. C., Tjonneland, A., Roswall, N., Overvad, K., Fagherazzi, G., Clavel-Chapelon, F., Dossus, L., Lukanova, Annekatrin, Grote, V., Bergmann, M. M., Boeing, H., Trichopoulou, A., Tzivoglou, M., Trichopoulos, D., Grioni, S., Mattiello, A., Masala, G., Tumino, R., Vineis, P., Bueno-de-Mesquita, H. B., Weiderpass, E., Redondo, M. L., Sanchez, M. J., Castano, J. M. Huerta, Arriola, L., Ardanaz, E., Duell, E. J., Rolandsson, O., Franks, P. W., Butt, S., Nilsson, P., Khaw, K. T., Wareham, N., Travis, R., Romieu, I., Gunter, M. J., Riboli, E., and van der Schouw, Y. T.
Abstract: The age at natural menopause (ANM) in the Western world ranges from 40 to 60 years, with an average onset of 51 years. The exact mechanisms underlying the timing of ANM are not completely understood. Both genetic and environmental factors are involved. The best-established environmental factor affecting ANM is smoking; menopause occurs 1 to 2 years earlier in smokers. In addition to genetic and environmental factors, chronic metabolic diseases may influence ANM. Some evidence suggests that diabetes may accelerate menopausal onset. With more women of childbearing age receiving a diagnosis of diabetes, it is important to examine the impact of diabetes on reproductive health. This study was designed to determine whether ANM occurs at an earlier age among women who have diabetes before menopause than in women without diabetes. Data were obtained from the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a large multicenter prospective cohort study investigating the relationship between diet, lifestyle, and genetic factors and the incidence of cancer and other chronic diseases. A cohort of 519,978 men and women, mostly aged 27 to 70 years, were recruited primarily from the general population between 1992 and 2000. A total of 367,331 women participated in the EPIC study. After exclusions, 258,898 of these women met study inclusion criteria. Diabetes status at baseline and menopausal age were based on self-report and were obtained through questionnaires. Participants were asked if they had ever been diagnosed with diabetes and if so at what age. Associations of diabetes and age at diabetes diagnosis with ANM were estimated using time-dependent Cox regression analyses, with stratification by center and adjustments for age, smoking, reproductive, and known diabetes risk factors including smoking and with age from birth to menopause or censoring as the underlying time scale. Overall, there was no statistically significant lower risk of becoming menopa
Published: 2015
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30. Diabetes and onset of natural menopause : results from the European Prospective Investigation into Cancer and Nutrition

Author: Brand, J. S., Onland-Moret, N. C., Eijkemans, M. J. C., Tjönneland, A., Roswall, N., Overvad, K., Fagherazzi, G., Clavel-Chapelon, F., Dossus, L., Lukanova, Annekatrin, Grote, V., Bergmann, M. M., Boeing, H., Trichopoulou, A., Tzivoglou, M., Trichopoulos, D., Grioni, S., Mattiello, A., Masala, G., Tumino, R., Vineis, P., Bueno-De-Mesquita, H. B., Weiderpass, E., Redondo, M. L., Sanchez, M. J., Huerta Castano, J. M., Arriola, L., Ardanaz, E., Duell, E. J., Rolandsson, Olov, Franks, Paul, Butt, S., Nilsson, P., Khaw, K. T., Wareham, N., Travis, R., Romieu, I., Gunter, M. J., Riboli, E., van der Schouw, Y. T., Brand, J. S., Onland-Moret, N. C., Eijkemans, M. J. C., Tjönneland, A., Roswall, N., Overvad, K., Fagherazzi, G., Clavel-Chapelon, F., Dossus, L., Lukanova, Annekatrin, Grote, V., Bergmann, M. M., Boeing, H., Trichopoulou, A., Tzivoglou, M., Trichopoulos, D., Grioni, S., Mattiello, A., Masala, G., Tumino, R., Vineis, P., Bueno-De-Mesquita, H. B., Weiderpass, E., Redondo, M. L., Sanchez, M. J., Huerta Castano, J. M., Arriola, L., Ardanaz, E., Duell, E. J., Rolandsson, Olov, Franks, Paul, Butt, S., Nilsson, P., Khaw, K. T., Wareham, N., Travis, R., Romieu, I., Gunter, M. J., Riboli, E., and van der Schouw, Y. T.
Abstract: STUDY QUESTION: Do women who have diabetes before menopause have their menopause at an earlier age compared with women without diabetes? SUMMARY ANSWER: Although there was no overall association between diabetes and age at menopause, our study suggests that early-onset diabetes may accelerate menopause. WHAT IS KNOWN ALREADY: Today, more women of childbearing age are being diagnosed with diabetes, but little is known about the impact of diabetes on reproductive health. STUDY DESIGN, SIZE, DURATION: We investigated the impact of diabetes on age at natural menopause (ANM) in 258 898 women from the European Prospective Investigation into Cancer and Nutrition (EPIC), enrolled between 1992 and 2000. PARTICIPANTS/MATERIALS, SETTING, METHODS: Determinant and outcome information was obtained through questionnaires. Time-dependent Cox regression analyses were used to estimate the associations of diabetes and age at diabetes diagnosis with ANM, stratified by center and adjusted for age, smoking, reproductive and diabetes risk factors and with age from birth to menopause or censoring as the underlying time scale. MAIN RESULTS AND THE ROLE OF CHANCE: Overall, no association between diabetes and ANM was found (hazard ratio (HR) = 0.94; 95% confidence interval (CI) 0.89-1.01). However, women with diabetes before the age of 20 years had an earlier menopause (10-20 years: HR = 1.43; 95% CI 1.02-2.01, <10 years: HR = 1.59; 95% CI 1.03-2.43) compared with non-diabetic women, whereas women with diabetes at age 50 years and older had a later menopause (HR = 0.81; 95% CI 0.70-0.95). None of the other age groups were associated with ANM. LIMITATIONS, REASONS FOR CAUTION: Strengths of the study include the large sample size and the broad set of potential confounders measured. However, results may have been underestimated due to survival bias. We cannot be sure about the sequence of the events in women with a late age at diabetes, as both events then occur in a short period. We could no
Published: 2015
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31. An epidemiologic risk prediction model for ovarian cancer in Europe: The EPIC study

Author: Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Li, K., Huesing, A., Fortner, R. T., Tjonneland, A., Hansen, L., Dossus, L., Chang-Claude, J., Bergmann, M., Steffen, A., Bamia, C., Trichopoulos, D., Trichopoulou, A., Palli, D., Mattiello, A., Agnoli, C., Tumino, R., Onland-Moret, N. C., Peeters, P. H., Bueno-de-Mesquita, H. B(as), Gram, I. T., Weiderpass, E., Sanchez-Cantalejo, E., Chirlaque, M-D, Duell, E. J., Ardanaz, E., Idahl, A., Lundin, E., Khaw, K-T, Travis, R. C., Merritt, M. A., Gunter, M. J., Riboli, E., Ferrari, P., Terry, K., Cramer, D., Kaaks, R., Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Cardiovasculaire Epi Team 3, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Li, K., Huesing, A., Fortner, R. T., Tjonneland, A., Hansen, L., Dossus, L., Chang-Claude, J., Bergmann, M., Steffen, A., Bamia, C., Trichopoulos, D., Trichopoulou, A., Palli, D., Mattiello, A., Agnoli, C., Tumino, R., Onland-Moret, N. C., Peeters, P. H., Bueno-de-Mesquita, H. B(as), Gram, I. T., Weiderpass, E., Sanchez-Cantalejo, E., Chirlaque, M-D, Duell, E. J., Ardanaz, E., Idahl, A., Lundin, E., Khaw, K-T, Travis, R. C., Merritt, M. A., Gunter, M. J., Riboli, E., Ferrari, P., Terry, K., Cramer, D., and Kaaks, R.
Published: 2015

32. Diabetes and onset of natural menopause: Results from the European Prospective Investigation into Cancer and Nutrition

Author: Cardiovasculaire Epi Team 3, Circulatory Health, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Biostatistiek Onderzoek, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, MS MDL 1, Cardiovasculaire Epidemiologie, Brand, J. S., Onland-Moret, N. C., Eijkemans, M. J C, Tjønneland, A., Roswall, N., Overvad, K., Fagherazzi, G., Clavel-Chapelon, F., Dossus, L., Lukanova, A., Grote, V., Bergmann, M. M., Boeing, H., Trichopoulou, A., Tzivoglou, M., Trichopoulos, D., Grioni, S., Mattiello, A., Masala, G., Tumino, R., Vineis, P., Bueno-De-Mesquita, H. B., Weiderpass, E., Redondo, M. L., Sánchez, M. J., Castaño, J. M Huerta, Arriola, L., Ardanaz, E., Duell, E. J., Rolandsson, O., Franks, P. W., Butt, S., Nilsson, P., Khaw, K. T., Wareham, N., Travis, R., Romieu, I., Gunter, M. J., Riboli, E., Van Der Schouw, Y. T., Cardiovasculaire Epi Team 3, Circulatory Health, Cancer, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, JC onderzoeksprogramma Kanker, Biostatistiek Onderzoek, JC onderzoeksprogramma Infectieziekten, JC onderzoeksprogramma Methodologie, MS MDL 1, Cardiovasculaire Epidemiologie, Brand, J. S., Onland-Moret, N. C., Eijkemans, M. J C, Tjønneland, A., Roswall, N., Overvad, K., Fagherazzi, G., Clavel-Chapelon, F., Dossus, L., Lukanova, A., Grote, V., Bergmann, M. M., Boeing, H., Trichopoulou, A., Tzivoglou, M., Trichopoulos, D., Grioni, S., Mattiello, A., Masala, G., Tumino, R., Vineis, P., Bueno-De-Mesquita, H. B., Weiderpass, E., Redondo, M. L., Sánchez, M. J., Castaño, J. M Huerta, Arriola, L., Ardanaz, E., Duell, E. J., Rolandsson, O., Franks, P. W., Butt, S., Nilsson, P., Khaw, K. T., Wareham, N., Travis, R., Romieu, I., Gunter, M. J., Riboli, E., and Van Der Schouw, Y. T.
Published: 2015

33. Dietary intake of acrylamide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Obon-Santacana, M. Slimani, N. Lujan-Barroso, L. Travier, N. and Hallmans, G. Freisling, H. Ferrari, P. Boutron-Ruault, M. C. Racine, A. Clavel, F. Saieva, C. Pala, V. and Tumino, R. Mattiello, A. Vineis, P. Argueelles, M. and Ardanaz, E. Amiano, P. Navarro, C. Sanchez, M. J. and Montes, E. Molina Key, T. Khaw, K. -T. Wareham, N. and Peeters, P. H. Trichopoulou, A. Bamia, C. Trichopoulos, D. and Boeing, H. Kaaks, R. Katzke, V. Ye, W. Sund, M. and Ericson, U. Wirfalt, E. Overvad, K. Tjonneland, A. and Olsen, A. Skeie, G. Asli, L. A. Weiderpass, E. Riboli, E. Bueno-De-Mesquita, H. B. Duell, E. J.
Abstract: In 1994, acrylamide (AA) was classified as a probable human carcinogen by the International Agency for Research on Cancer. In 2002, AA was discovered at relatively high concentrations in some starchy, plant-based foods cooked at high temperatures. A prospective analysis was conducted to evaluate the association between the dietary intake of AA and ductal adenocarcinoma of the exocrine pancreatic cancer (PC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort using Cox regression modeling. EPIC includes > 500 000 men and women aged 35-75 at enrollment from 10 European countries. AA intake was estimated for each participant by combining questionnaire-based food consumption data with a harmonized AA database derived from the EU monitoring database of AA levels in foods, and evaluated in quintiles and continuously. After a mean follow-up of 11 years, 865 first incident adenocarcinomas of the exocrine pancreas were observed and included in the present analysis. At baseline, the mean dietary AA intake in EPIC was 26.22 mu g/day. No overall association was found between continuous or quintiles of dietary AA intake and PC risk in EPIC (HR:0.95, 95%CI:0.89-1.01 per 10 mu g/day). There was no effect measure modification by smoking status, sex, diabetes, alcohol intake or geographic region. However, there was an inverse association (HR: 0.73, 95% CI: 0.61-0.88 per 10 mu g/day) between AA intake and PC risk in obese persons as defined using the body mass index (BMI, >= 30 kg/m(2)), but not when body fatness was defined using waist and hip circumference or their ratio. Dietary intake of AA was not associated with an increased risk of PC in the EPIC cohort.
Published: 2013

34. Inflammation marker and risk of pancreatic cancer: a nested case-control study within the EPIC cohort

Author: Grote, V. A. Kaaks, R. Nieters, A. Tjonneland, A. and Halkjaer, J. Overvad, K. Nielsen, M. R. Skjelbo and Boutron-Ruault, M. C. Clavel-Chapelon, F. Racine, A. and Teucher, B. Becker, S. Pischon, T. Boeing, H. and Trichopoulou, A. Cassapa, C. Stratigakou, V. Palli, D. and Krogh, V. Tumino, R. Vineis, P. Panico, S. Rodriguez, L. and Duell, E. J. Sanchez, M-J Dorronsoro, M. Navarro, C. and Gurrea, A. B. Siersema, P. D. Peeters, P. H. M. Ye, W. and Sund, M. Lindkvist, B. Johansen, D. Khaw, K-T Wareham, N. Allen, N. E. Travis, R. C. Fedirko, V. Jenab, M. and Michaud, D. S. Chuang, S-C Romaguera, D. Bueno-de-Mesquita, H. B. Rohrmann, S.
Abstract: BACKGROUND: Established risk factors for pancreatic cancer include smoking, long-standing diabetes, high body fatness, and chronic pancreatitis, all of which can be characterised by aspects of inflammatory processes. However, prospective studies investigating the relation between inflammatory markers and pancreatic cancer risk are scarce. METHODS: We conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition, measuring prediagnostic blood levels of C-reactive protein (CRP), interleukin-6 (IL-6), and soluble receptors of tumour necrosis factor-a (sTNF-R1, R2) in 455 pancreatic cancer cases and 455 matched controls. Odds ratios (ORs) were estimated using conditional logistic regression models. RESULTS: None of the inflammatory markers were significantly associated with risk of pancreatic cancer overall, although a borderline significant association was observed for higher circulating sTNF-R2 (crude OR = 1.52 (95% confidence interval (CI) 0.97-2.39), highest vs lowest quartile). In women, however, higher sTNF-R1 levels were significantly associated with risk of pancreatic cancer (crude OR = 1.97 (95% CI 1.02-3.79)). For sTNF-R2, risk associations seemed to be stronger for diabetic individuals and those with a higher BMI. CONCLUSION: Prospectively, CRP and IL-6 do not seem to have a role in our study with respect to risk of pancreatic cancer, whereas sTNF-R1 seemed to be a risk factor in women and sTNF-R2 might be a mediator in the risk relationship between overweight and diabetes with pancreatic cancer. Further large prospective studies are needed to clarify the role of proinflammatory proteins and cytokines in the pathogenesis of exocrine pancreatic cancer. British Journal of Cancer (2012) 106, 1866-1874. doi:10.1038/bjc.2012.172 www.bjcancer.com Published online 26 April 2012 (C) 2012 Cancer Research UK
Published: 2012

35. Concentrations of IGF-I and IGFBP-3 and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition

Author: Rohrmann, S. Grote, V. A. Becker, S. Rinaldi, S. and Tjonneland, A. Roswall, N. Gronbaek, H. Overvad, K. and Boutron-Ruault, M. C. Clavel-Chapelon, F. Racine, A. and Teucher, B. Boeing, H. Drogan, D. Dilis, V. Lagiou, P. and Trichopoulou, A. Palli, D. Tagliabue, G. Tumino, R. and Vineis, P. Mattiello, A. Rodriguez, L. Duell, E. J. and Molina-Montes, E. Dorronsoro, M. Huerta, J-M Ardanaz, E. and Jeurnink, S. Peeters, P. H. M. Lindkvist, B. Johansen, D. and Sund, M. Ye, W. Khaw, K-T Wareham, N. J. Allen, N. E. Crowe, F. L. Fedirko, V. Jenab, M. Michaud, D. S. and Norat, T. Riboli, E. Bueno-de-Mesquita, H. B. Kaaks, R.
Abstract: BACKGROUND: Insulin-like growth factors (IGFs) and their binding proteins (BPs) regulate cell differentiation, proliferation and apoptosis, and may have a role in the aetiology of various cancers. Information on their role in pancreatic cancer is limited and was examined here in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition. METHODS: Serum concentrations of IGF-I and IGFBP-3 were measured using enzyme-linked immunosorbent assays in 422 cases and 422 controls matched on age, sex, study centre, recruitment date, and time since last meal. Conditional logistic regression was used to compute odds ratios (OR) and 95% confidence intervals (CI) adjusted for confounding variables. RESULTS: Neither circulating levels of IGF-I (OR = 1.21, 95% CI 0.75-1.93 for top vs bottom quartile, P-trend 0.301), IGFBP-3 (OR = 1.00, 95% CI 0.66-1.51, P-trend 0.79), nor the molar IGF-I/IGFBP-3 ratio, an indicator of free IGF-I level (OR = 1.22, 95% CI 0.75-1.97, P-trend 0.27), were statistically significantly associated with the risk of pancreatic cancer. In a cross-classification, however, a high concentration of IGF-I with concurrently low levels of IGFBP-3 was related to an increased risk of pancreatic cancer (OR = 1.72, 95% CI 1.05-2.83; P-interaction = 0.154). CONCLUSION: On the basis of these results, circulating levels of components of the IGF axis do not appear to be the risk factors for pancreatic cancer. However, on the basis of the results of a subanalysis, it cannot be excluded that a relatively large amount of IGF-1 together with very low levels of IGFBP-3 might still be associated with an increase in pancreatic cancer risk. British Journal of Cancer (2012) 106, 1004-1010. doi:10.1038/bjc.2012.19 www.bjcancer.com Published online 7 February 2012 (C) 2012 Cancer Research UK
Published: 2012

36. Primary brain tumours and specific serum immunoglobulin E: a case-control study nested in the European Prospective Investigation into Cancer and Nutrition cohort

Author: Schlehofer, B. Siegmund, B. Linseisen, J. Schuez, J. and Rohrmann, S. Becker, S. Michaud, D. Melin, B. and Bueno-de-Mesquita, H. Bas Peeters, P. H. M. Vineis, P. and Tjonneland, A. Olsen, A. Overvad, K. Romieu, I. Boeing, H. Aleksandrova, K. Trichopoulou, A. Bamia, C. Lagiou, P. Sacerdote, C. Palli, D. Panico, S. Sieri, S. and Tumino, R. Sanchez, M. -J. Rodriguez, L. Dorronsoro, M. and Duell, E. J. Chirlaque, M. -D. Barricarte, A. Borgquist, S. and Manjer, J. Gallo, V. Allen, N. E. Key, T. J. Riboli, E. Kaaks, R. Wahrendorf, J.
Abstract: Background: Case-control studies suggest that patients with allergic diseases have a lower risk of developing glioma but not meningioma or schwannoma. However, those data can be differentially biased. Prospective studies with objective measurements of immunologic biomarkers, like immunoglobulin E (IgE), in blood obtained before cancer diagnosis could help to clarify whether an aetiological association exists. Methods: The present case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) measured specific serum IgE as a biomarker for the most common inhalant allergens in 275 glioma, 175 meningioma and 49 schwannoma cases and 963 matched controls using the ImmunoCAP specific IgE test. Subjects with an IgE level >= 0.35 kUA/l (kilo antibody units per litre) were classified as sensitized by allergens. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by adjusted conditional logistic regression models for each tumour subtype. The effect of dose-response relationship was assessed in five increasing IgE level categories to estimate P-values for trend. Results: The risk of glioma was inversely related to allergic sensitization (OR = 0.73; 95% CI 0.51-1.06), especially pronounced in women (OR = 0.53; 95% CI 0.30-0.95). In dose-response analyses, for high-grade glioma, the lowest OR was observed in sera with the highest IgE levels (P for trend = 0.04). No association was seen for meningioma and schwannoma. Conclusion: The results, based on serum samples prospectively collected in a cohort study, provide some support for the hypothesis that individuals with allergic sensitization are at reduced risk of glioma and confirm results from previous case-control studies.
Published: 2011

37. Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies

Author: Key, T. J. Appleby, P. N. Reeves, G. K. Roddam, A. W. and Helzlsouer, K. J. Alberg, A. J. Rollison, D. E. Dorgan, J. F. Brinton, L. A. Overvad, K. Kaaks, R. Trichopoulou, A. and Clavel-Chapelon, F. Panico, S. Duell, E. J. Peeters, P. H. M. Rinaldi, S. Riboli, E. Fentiman, I. S. Dowsett, M. and Manjer, J. Lenner, P. Hallmans, G. Baglietto, L. and English, D. R. Giles, G. G. Hopper, J. L. Severi, G. and Morris, H. A. Koenig, K. Zeleniuch-Jacquotte, A. Arslan, A. A. Toniolo, P. Shore, R. E. Krogh, V. Micheli, A. and Berrino, F. Muti, P. Barrett-Connor, E. Laughlin, G. A. and Kabuto, M. Akiba, S. Stevens, R. G. Neriishi, K. Land, C. E. Cauley, J. A. Lui, Li Yung Cummings, Steven R. and Gunter, M. J. Rohan, T. E. Strickler, H. D. Endogenous Hormones Breast Canc
Abstract: BACKGROUND: Breast cancer risk for postmenopausal women is positively associated with circulating concentrations of oestrogens and androgens, but the determinants of these hormones are not well understood. METHODS: Cross-sectional analyses of breast cancer risk factors and circulating hormone concentrations in more than 6000 postmenopausal women controls in 13 prospective studies. RESULTS: Concentrations of all hormones were lower in older than younger women, with the largest difference for dehydroepiandrosterone sulphate (DHEAS), whereas sex hormone-binding globulin (SHBG) was higher in the older women. Androgens were lower in women with bilateral ovariectomy than in naturally postmenopausal women, with the largest difference for free testosterone. All hormones were higher in obese than lean women, with the largest difference for free oestradiol, whereas SHBG was lower in obese women. Smokers of 15+ cigarettes per day had higher levels of all hormones than non-smokers, with the largest difference for testosterone. Drinkers of 20+ g alcohol per day had higher levels of all hormones, but lower SHBG, than non-drinkers, with the largest difference for DHEAS. Hormone concentrations were not strongly related to age at menarche, parity, age at first full-term pregnancy or family history of breast cancer. CONCLUSION: Sex hormone concentrations were strongly associated with several established or suspected risk factors for breast cancer, and may mediate the effects of these factors on breast cancer risk. British Journal of Cancer (2011) 105, 709-722. doi:10.1038/bjc.2011.254 www.bjcancer.com Published online 19 July 2011 (C) 2011 Cancer Research UK
Published: 2011

38. Diabetes mellitus, glycated haemoglobin and C-peptide levels in relation to pancreatic cancer risk: a study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Author: Grote, V. A. Rohrmann, S. Nieters, A. Dossus, L. and Tjonneland, A. Halkjaer, J. Overvad, K. Fagherazzi, G. and Boutron-Ruault, M. C. Morois, S. Teucher, B. Becker, S. and Sluik, D. Boeing, H. Trichopoulou, A. Lagiou, P. and Trichopoulos, D. Palli, D. Pala, V. Tumino, R. Vineis, P. Panico, S. Rodriguez, L. Duell, E. J. Molina-Montes, E. Dorronsoro, M. Huerta, J. M. Ardanaz, E. Jeurnink, S. M. Beulens, J. W. J. Peeters, P. H. M. Sund, M. Ye, W. and Lindkvist, B. Johansen, D. Khaw, K. T. Wareham, N. and Allen, N. Crowe, F. Jenab, M. Romieu, I. Michaud, D. S. and Riboli, E. Romaguera, D. Bueno-de-Mesquita, H. B. Kaaks, R.
Abstract: Aims/hypothesis There has been long-standing debate about whether diabetes is a causal risk factor for pancreatic cancer or a consequence of tumour development. Prospective epidemiological studies have shown variable relationships between pancreatic cancer risk and blood markers of glucose and insulin metabolism, overall and as a function of lag times between marker measurements (blood donation) and date of tumour diagnosis. Methods Pre-diagnostic levels of HbA(1c) and C-peptide were measured for 466 participants with pancreatic cancer and 466 individually matched controls within the European Prospective Investigation into Cancer and Nutrition. Conditional logistic regression models were used to estimate ORs for pancreatic cancer. Results Pancreatic cancer risk gradually increased with increasing pre-diagnostic HbA(1c) levels up to an OR of 2.42 (95% CI 1.33, 4.39 highest [>= 6.5%, 48 mmol/mol] vs lowest [
Published: 2011

39. Diabetes and Onset of Natural Menopause

Author: Brand, J. S., primary, Onland-Moret, N. C., additional, Eijkemans, M. J. C., additional, Tjønneland, A., additional, Roswall, N., additional, Overvad, K., additional, Fagherazzi, G., additional, Clavel-Chapelon, F., additional, Dossus, L., additional, Lukanova, A., additional, Grote, V., additional, Bergmann, M. M., additional, Boeing, H., additional, Trichopoulou, A., additional, Tzivoglou, M., additional, Trichopoulos, D., additional, Grioni, S., additional, Mattiello, A., additional, Masala, G., additional, Tumino, R., additional, Vineis, P., additional, Bueno-de-Mesquita, H. B., additional, Weiderpass, E., additional, Redondo, M. L., additional, Sánchez, M. J., additional, Huerta Castaño, J. M., additional, Arriola, L., additional, Ardanaz, E., additional, Duell, E. J., additional, Rolandsson, O., additional, Franks, P. W., additional, Butt, S., additional, Nilsson, P., additional, Khaw, K. T., additional, Wareham, N., additional, Travis, R., additional, Romieu, I., additional, Gunter, M. J., additional, Riboli, E., additional, and van der Schouw, Y. T., additional
Published: 2015
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40. Diabetes and onset of natural menopause: results from the European Prospective Investigation into Cancer and Nutrition

Author: Brand, J. S., primary, Onland-Moret, N. C., additional, Eijkemans, M. J. C., additional, Tjonneland, A., additional, Roswall, N., additional, Overvad, K., additional, Fagherazzi, G., additional, Clavel-Chapelon, F., additional, Dossus, L., additional, Lukanova, A., additional, Grote, V., additional, Bergmann, M. M., additional, Boeing, H., additional, Trichopoulou, A., additional, Tzivoglou, M., additional, Trichopoulos, D., additional, Grioni, S., additional, Mattiello, A., additional, Masala, G., additional, Tumino, R., additional, Vineis, P., additional, Bueno-de-Mesquita, H. B., additional, Weiderpass, E., additional, Redondo, M. L., additional, Sanchez, M. J., additional, Castano, J. M. H., additional, Arriola, L., additional, Ardanaz, E., additional, Duell, E. J., additional, Rolandsson, O., additional, Franks, P. W., additional, Butt, S., additional, Nilsson, P., additional, Khaw, K. T., additional, Wareham, N., additional, Travis, R., additional, Romieu, I., additional, Gunter, M. J., additional, Riboli, E., additional, and van der Schouw, Y. T., additional
Published: 2015
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41. An epidemiologic risk prediction model for ovarian cancer in Europe: the EPIC study

Author: Li, K, primary, Hüsing, A, additional, Fortner, R T, additional, Tjønneland, A, additional, Hansen, L, additional, Dossus, L, additional, Chang-Claude, J, additional, Bergmann, M, additional, Steffen, A, additional, Bamia, C, additional, Trichopoulos, D, additional, Trichopoulou, A, additional, Palli, D, additional, Mattiello, A, additional, Agnoli, C, additional, Tumino, R, additional, Onland-Moret, N C, additional, Peeters, P H, additional, Bueno-de-Mesquita, H B(as), additional, Gram, I T, additional, Weiderpass, E, additional, Sánchez-Cantalejo, E, additional, Chirlaque, M-D, additional, Duell, E J, additional, Ardanaz, E, additional, Idahl, A, additional, Lundin, E, additional, Khaw, K-T, additional, Travis, R C, additional, Merritt, M A, additional, Gunter, M J, additional, Riboli, E, additional, Ferrari, P, additional, Terry, K, additional, Cramer, D, additional, and Kaaks, R, additional
Published: 2015
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42. Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Author: Obón-Santacana, M., Kaaks, R., Slimani, N., Lujan-Barroso, L., Freisling, H., Ferrari, P., Dossus, L., Chabbert-Buffet, N., Baglietto, L., Fortner, R. T., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Menéndez, V., Molina-Montes, E., Larrañaga, N., Chirlaque, M-D, Ardanaz, E., Khaw, K-T, Wareham, N., Travis, R. C., Lu, Y., Merritt, M. A., Trichopoulou, A., Benetou, V., Trichopoulos, D., Saieva, C., Sieri, S., Tumino, R., Sacerdote, C., Galasso, R., Bueno-de-Mesquita, H. B., Wirfalt, E., Ericson, U., Idahl, Annika, Ohlson, Nina, Skeie, G., Gram, I. T., Weiderpass, E., Onland-Moret, N. C., Riboli, E., Duell, E. J., Obón-Santacana, M., Kaaks, R., Slimani, N., Lujan-Barroso, L., Freisling, H., Ferrari, P., Dossus, L., Chabbert-Buffet, N., Baglietto, L., Fortner, R. T., Boeing, H., Tjønneland, A., Olsen, A., Overvad, K., Menéndez, V., Molina-Montes, E., Larrañaga, N., Chirlaque, M-D, Ardanaz, E., Khaw, K-T, Wareham, N., Travis, R. C., Lu, Y., Merritt, M. A., Trichopoulou, A., Benetou, V., Trichopoulos, D., Saieva, C., Sieri, S., Tumino, R., Sacerdote, C., Galasso, R., Bueno-de-Mesquita, H. B., Wirfalt, E., Ericson, U., Idahl, Annika, Ohlson, Nina, Skeie, G., Gram, I. T., Weiderpass, E., Onland-Moret, N. C., Riboli, E., and Duell, E. J.
Abstract: BACKGROUND: Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk. METHODS: Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method. RESULTS: No associations were observed between acrylamide intake and overall EC (n = 1382) or type-I EC risk (n = 627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n = 203). CONCLUSIONS: Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.
Published: 2014
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43. Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort.

Author: Obón-Santacana, M, Kaaks, R, Slimani, N, Lujan-Barroso, L, Freisling, H, Ferrari, P, Dossus, L, Chabbert-Buffet, N, Baglietto, L, Fortner, R T, Boeing, H, Tjønneland, A, Olsen, A, Overvad, K, Menéndez, V, Molina-Montes, E, Larrañaga, N, Chirlaque, M-D, Ardanaz, E, Khaw, K-T, Wareham, N, Travis, R C, Lu, Y, Merritt, M A, Trichopoulou, A, Benetou, V, Trichopoulos, D, Saieva, C, Sieri, S, Tumino, R, Sacerdote, C, Galasso, R, Bueno-de-Mesquita, H B, Wirfält, Elisabet, Ericson, Ulrika, Idahl, A, Ohlson, N, Skeie, G, Gram, I T, Weiderpass, E, Onland-Moret, N C, Riboli, E, Duell, E J, Obón-Santacana, M, Kaaks, R, Slimani, N, Lujan-Barroso, L, Freisling, H, Ferrari, P, Dossus, L, Chabbert-Buffet, N, Baglietto, L, Fortner, R T, Boeing, H, Tjønneland, A, Olsen, A, Overvad, K, Menéndez, V, Molina-Montes, E, Larrañaga, N, Chirlaque, M-D, Ardanaz, E, Khaw, K-T, Wareham, N, Travis, R C, Lu, Y, Merritt, M A, Trichopoulou, A, Benetou, V, Trichopoulos, D, Saieva, C, Sieri, S, Tumino, R, Sacerdote, C, Galasso, R, Bueno-de-Mesquita, H B, Wirfält, Elisabet, Ericson, Ulrika, Idahl, A, Ohlson, N, Skeie, G, Gram, I T, Weiderpass, E, Onland-Moret, N C, Riboli, E, and Duell, E J
Abstract: Background:Three prospective studies have evaluated the association between dietary acrylamide intake and endometrial cancer (EC) risk with inconsistent results. The objective of this study was to evaluate the association between acrylamide intake and EC risk: for overall EC, for type-I EC, and in never smokers and never users of oral contraceptives (OCs). Smoking is a source of acrylamide, and OC use is a protective factor for EC risk.Methods:Cox regression was used to estimate hazard ratios (HRs) for the association between acrylamide intake and EC risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Acrylamide intake was estimated from the EU acrylamide monitoring database, which was matched with EPIC questionnaire-based food consumption data. Acrylamide intake was energy adjusted using the residual method.Results:No associations were observed between acrylamide intake and overall EC (n=1382) or type-I EC risk (n=627). We observed increasing relative risks for type-I EC with increasing acrylamide intake among women who both never smoked and were non-users of OCs (HRQ5vsQ1: 1.97, 95% CI: 1.08-3.62; likelihood ratio test (LRT) P-value: 0.01, n=203).Conclusions:Dietary intake of acrylamide was not associated with overall or type-I EC risk; however, positive associations with type I were observed in women who were both non-users of OCs and never smokers.British Journal of Cancer advance online publication, 17 June 2014; doi:10.1038/bjc.2014.328 www.bjcancer.com.
Published: 2014

44. Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33

Author: Wang, Z., primary, Zhu, B., additional, Zhang, M., additional, Parikh, H., additional, Jia, J., additional, Chung, C. C., additional, Sampson, J. N., additional, Hoskins, J. W., additional, Hutchinson, A., additional, Burdette, L., additional, Ibrahim, A., additional, Hautman, C., additional, Raj, P. S., additional, Abnet, C. C., additional, Adjei, A. A., additional, Ahlbom, A., additional, Albanes, D., additional, Allen, N. E., additional, Ambrosone, C. B., additional, Aldrich, M., additional, Amiano, P., additional, Amos, C., additional, Andersson, U., additional, Andriole, G., additional, Andrulis, I. L., additional, Arici, C., additional, Arslan, A. A., additional, Austin, M. A., additional, Baris, D., additional, Barkauskas, D. A., additional, Bassig, B. A., additional, Beane Freeman, L. E., additional, Berg, C. D., additional, Berndt, S. I., additional, Bertazzi, P. A., additional, Biritwum, R. B., additional, Black, A., additional, Blot, W., additional, Boeing, H., additional, Boffetta, P., additional, Bolton, K., additional, Boutron-Ruault, M.-C., additional, Bracci, P. M., additional, Brennan, P., additional, Brinton, L. A., additional, Brotzman, M., additional, Bueno-de-Mesquita, H. B., additional, Buring, J. E., additional, Butler, M. A., additional, Cai, Q., additional, Cancel-Tassin, G., additional, Canzian, F., additional, Cao, G., additional, Caporaso, N. E., additional, Carrato, A., additional, Carreon, T., additional, Carta, A., additional, Chang, G.-C., additional, Chang, I.-S., additional, Chang-Claude, J., additional, Che, X., additional, Chen, C.-J., additional, Chen, C.-Y., additional, Chen, C.-H., additional, Chen, C., additional, Chen, K.-Y., additional, Chen, Y.-M., additional, Chokkalingam, A. P., additional, Chu, L. W., additional, Clavel-Chapelon, F., additional, Colditz, G. A., additional, Colt, J. S., additional, Conti, D., additional, Cook, M. B., additional, Cortessis, V. K., additional, Crawford, E. D., additional, Cussenot, O., additional, Davis, F. G., additional, De Vivo, I., additional, Deng, X., additional, Ding, T., additional, Dinney, C. P., additional, Di Stefano, A. L., additional, Diver, W. R., additional, Duell, E. J., additional, Elena, J. W., additional, Fan, J.-H., additional, Feigelson, H. S., additional, Feychting, M., additional, Figueroa, J. D., additional, Flanagan, A. M., additional, Fraumeni, J. F., additional, Freedman, N. D., additional, Fridley, B. L., additional, Fuchs, C. S., additional, Gago-Dominguez, M., additional, Gallinger, S., additional, Gao, Y.-T., additional, Gapstur, S. M., additional, Garcia-Closas, M., additional, Garcia-Closas, R., additional, Gastier-Foster, J. M., additional, Gaziano, J. M., additional, Gerhard, D. S., additional, Giffen, C. A., additional, Giles, G. G., additional, Gillanders, E. M., additional, Giovannucci, E. L., additional, Goggins, M., additional, Gokgoz, N., additional, Goldstein, A. M., additional, Gonzalez, C., additional, Gorlick, R., additional, Greene, M. H., additional, Gross, M., additional, Grossman, H. B., additional, Grubb, R., additional, Gu, J., additional, Guan, P., additional, Haiman, C. A., additional, Hallmans, G., additional, Hankinson, S. E., additional, Harris, C. C., additional, Hartge, P., additional, Hattinger, C., additional, Hayes, R. B., additional, He, Q., additional, Helman, L., additional, Henderson, B. E., additional, Henriksson, R., additional, Hoffman-Bolton, J., additional, Hohensee, C., additional, Holly, E. A., additional, Hong, Y.-C., additional, Hoover, R. N., additional, Hosgood, H. D., additional, Hsiao, C.-F., additional, Hsing, A. W., additional, Hsiung, C. A., additional, Hu, N., additional, Hu, W., additional, Hu, Z., additional, Huang, M.-S., additional, Hunter, D. J., additional, Inskip, P. D., additional, Ito, H., additional, Jacobs, E. J., additional, Jacobs, K. B., additional, Jenab, M., additional, Ji, B.-T., additional, Johansen, C., additional, Johansson, M., additional, Johnson, A., additional, Kaaks, R., additional, Kamat, A. M., additional, Kamineni, A., additional, Karagas, M., additional, Khanna, C., additional, Khaw, K.-T., additional, Kim, C., additional, Kim, I.-S., additional, Kim, J. H., additional, Kim, Y. H., additional, Kim, Y.-C., additional, Kim, Y. T., additional, Kang, C. H., additional, Jung, Y. J., additional, Kitahara, C. M., additional, Klein, A. P., additional, Klein, R., additional, Kogevinas, M., additional, Koh, W.-P., additional, Kohno, T., additional, Kolonel, L. N., additional, Kooperberg, C., additional, Kratz, C. P., additional, Krogh, V., additional, Kunitoh, H., additional, Kurtz, R. C., additional, Kurucu, N., additional, Lan, Q., additional, Lathrop, M., additional, Lau, C. C., additional, Lecanda, F., additional, Lee, K.-M., additional, Lee, M. P., additional, Le Marchand, L., additional, Lerner, S. P., additional, Li, D., additional, Liao, L. M., additional, Lim, W.-Y., additional, Lin, D., additional, Lin, J., additional, Lindstrom, S., additional, Linet, M. S., additional, Lissowska, J., additional, Liu, J., additional, Ljungberg, B., additional, Lloreta, J., additional, Lu, D., additional, Ma, J., additional, Malats, N., additional, Mannisto, S., additional, Marina, N., additional, Mastrangelo, G., additional, Matsuo, K., additional, McGlynn, K. A., additional, McKean-Cowdin, R., additional, McNeill, L. H., additional, McWilliams, R. R., additional, Melin, B. S., additional, Meltzer, P. S., additional, Mensah, J. E., additional, Miao, X., additional, Michaud, D. S., additional, Mondul, A. M., additional, Moore, L. E., additional, Muir, K., additional, Niwa, S., additional, Olson, S. H., additional, Orr, N., additional, Panico, S., additional, Park, J. Y., additional, Patel, A. V., additional, Patino-Garcia, A., additional, Pavanello, S., additional, Peeters, P. H. M., additional, Peplonska, B., additional, Peters, U., additional, Petersen, G. M., additional, Picci, P., additional, Pike, M. C., additional, Porru, S., additional, Prescott, J., additional, Pu, X., additional, Purdue, M. P., additional, Qiao, Y.-L., additional, Rajaraman, P., additional, Riboli, E., additional, Risch, H. A., additional, Rodabough, R. J., additional, Rothman, N., additional, Ruder, A. M., additional, Ryu, J.-S., additional, Sanson, M., additional, Schned, A., additional, Schumacher, F. R., additional, Schwartz, A. G., additional, Schwartz, K. L., additional, Schwenn, M., additional, Scotlandi, K., additional, Seow, A., additional, Serra, C., additional, Serra, M., additional, Sesso, H. D., additional, Severi, G., additional, Shen, H., additional, Shen, M., additional, Shete, S., additional, Shiraishi, K., additional, Shu, X.-O., additional, Siddiq, A., additional, Sierrasesumaga, L., additional, Sierri, S., additional, Loon Sihoe, A. D., additional, Silverman, D. T., additional, Simon, M., additional, Southey, M. C., additional, Spector, L., additional, Spitz, M., additional, Stampfer, M., additional, Stattin, P., additional, Stern, M. C., additional, Stevens, V. L., additional, Stolzenberg-Solomon, R. Z., additional, Stram, D. O., additional, Strom, S. S., additional, Su, W.-C., additional, Sund, M., additional, Sung, S. W., additional, Swerdlow, A., additional, Tan, W., additional, Tanaka, H., additional, Tang, W., additional, Tang, Z.-Z., additional, Tardon, A., additional, Tay, E., additional, Taylor, P. R., additional, Tettey, Y., additional, Thomas, D. M., additional, Tirabosco, R., additional, Tjonneland, A., additional, Tobias, G. S., additional, Toro, J. R., additional, Travis, R. C., additional, Trichopoulos, D., additional, Troisi, R., additional, Truelove, A., additional, Tsai, Y.-H., additional, Tucker, M. A., additional, Tumino, R., additional, Van Den Berg, D., additional, Van Den Eeden, S. K., additional, Vermeulen, R., additional, Vineis, P., additional, Visvanathan, K., additional, Vogel, U., additional, Wang, C., additional, Wang, J., additional, Wang, S. S., additional, Weiderpass, E., additional, Weinstein, S. J., additional, Wentzensen, N., additional, Wheeler, W., additional, White, E., additional, Wiencke, J. K., additional, Wolk, A., additional, Wolpin, B. M., additional, Wong, M. P., additional, Wrensch, M., additional, Wu, C., additional, Wu, T., additional, Wu, X., additional, Wu, Y.-L., additional, Wunder, J. S., additional, Xiang, Y.-B., additional, Xu, J., additional, Yang, H. P., additional, Yang, P.-C., additional, Yatabe, Y., additional, Ye, Y., additional, Yeboah, E. D., additional, Yin, Z., additional, Ying, C., additional, Yu, C.-J., additional, Yu, K., additional, Yuan, J.-M., additional, Zanetti, K. A., additional, Zeleniuch-Jacquotte, A., additional, Zheng, W., additional, Zhou, B., additional, Mirabello, L., additional, Savage, S. A., additional, Kraft, P., additional, Chanock, S. J., additional, Yeager, M., additional, Landi, M. T., additional, Shi, J., additional, Chatterjee, N., additional, and Amundadottir, L. T., additional
Published: 2014
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45. Lifetime alcohol use and overall and cause-specific mortality in the European Prospective Investigation into Cancer and nutrition (EPIC) study

Author: Ferrari, P., primary, Licaj, I., additional, Muller, D. C., additional, Kragh Andersen, P., additional, Johansson, M., additional, Boeing, H., additional, Weiderpass, E., additional, Dossus, L., additional, Dartois, L., additional, Fagherazzi, G., additional, Bradbury, K. E., additional, Khaw, K.-T., additional, Wareham, N., additional, Duell, E. J., additional, Barricarte, A., additional, Molina-Montes, E., additional, Sanchez, C. N., additional, Arriola, L., additional, Wallstrom, P., additional, Tjonneland, A., additional, Olsen, A., additional, Trichopoulou, A., additional, Benetou, V., additional, Trichopoulos, D., additional, Tumino, R., additional, Agnoli, C., additional, Sacerdote, C., additional, Palli, D., additional, Li, K., additional, Kaaks, R., additional, Peeters, P., additional, Beulens, J. W., additional, Nunes, L., additional, Gunter, M., additional, Norat, T., additional, Overvad, K., additional, Brennan, P., additional, Riboli, E., additional, and Romieu, I., additional
Published: 2014
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46. Dietary intake of acrylamide and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition cohort

Author: Obón-Santacana, M, primary, Kaaks, R, additional, Slimani, N, additional, Lujan-Barroso, L, additional, Freisling, H, additional, Ferrari, P, additional, Dossus, L, additional, Chabbert-Buffet, N, additional, Baglietto, L, additional, Fortner, R T, additional, Boeing, H, additional, Tjønneland, A, additional, Olsen, A, additional, Overvad, K, additional, Menéndez, V, additional, Molina-Montes, E, additional, Larrañaga, N, additional, Chirlaque, M-D, additional, Ardanaz, E, additional, Khaw, K-T, additional, Wareham, N, additional, Travis, R C, additional, Lu, Y, additional, Merritt, M A, additional, Trichopoulou, A, additional, Benetou, V, additional, Trichopoulos, D, additional, Saieva, C, additional, Sieri, S, additional, Tumino, R, additional, Sacerdote, C, additional, Galasso, R, additional, Bueno-de-Mesquita, H B, additional, Wirfält, E, additional, Ericson, U, additional, Idahl, A, additional, Ohlson, N, additional, Skeie, G, additional, Gram, I T, additional, Weiderpass, E, additional, Onland-Moret, N C, additional, Riboli, E, additional, and Duell, E J, additional
Published: 2014
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47. Axonal guidance signaling pathway interacting with smoking in modifying the risk of pancreatic cancer: a gene- and pathway-based interaction analysis of GWAS data

Author: Tang, H., primary, Wei, P., additional, Duell, E. J., additional, Risch, H. A., additional, Olson, S. H., additional, Bueno-de-Mesquita, H. B., additional, Gallinger, S., additional, Holly, E. A., additional, Petersen, G., additional, Bracci, P. M., additional, McWilliams, R. R., additional, Jenab, M., additional, Riboli, E., additional, Tjonneland, A., additional, Boutron-Ruault, M. C., additional, Kaaks, R., additional, Trichopoulos, D., additional, Panico, S., additional, Sund, M., additional, Peeters, P. H. M., additional, Khaw, K.-T., additional, Amos, C. I., additional, and Li, D., additional
Published: 2014
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48. Diabetes and risk of pancreatic cancer : a pooled analysis from the pancreatic cancer cohort consortium

Author: Elena, J. W., Steplowski, E., Yu, K., Hartge, P., Tobias, G. S., Brotzman, M. J., Chanock, S. J., Stolzenberg-Solomon, R. Z., Arslan, A. A., Bueno-De-Mesquita, H. B., Helzlsouer, K., Jacobs, E. J., Lacroix, A., Petersen, G., Zheng, W., Albanes, D., Allen, N. E., Amundadottir, L., Bao, Y., Boeing, H., Boutron-Ruault, M. -C, Buring, J. E., Gaziano, J. M., Giovannucci, E. L., Duell, E. J., Hallmans, Göran, Howard, B. V., Hunter, D. J., Hutchinson, A., Jacobs, K. B., Kooperberg, C., Kraft, P., Mendelsohn, J. B., Michaud, D. S., Palli, D., Phillips, L. S., Overvad, K., Patel, A. V., Sansbury, L., Shu, X. -O, Simon, M. S., Slimani, N., Trichopoulos, D., Visvanathan, K., Virtamo, J., Wolpin, B. M., Zeleniuch-Jacquotte, A., Fuchs, C. S., Hoover, R. N., Gross, M., Elena, J. W., Steplowski, E., Yu, K., Hartge, P., Tobias, G. S., Brotzman, M. J., Chanock, S. J., Stolzenberg-Solomon, R. Z., Arslan, A. A., Bueno-De-Mesquita, H. B., Helzlsouer, K., Jacobs, E. J., Lacroix, A., Petersen, G., Zheng, W., Albanes, D., Allen, N. E., Amundadottir, L., Bao, Y., Boeing, H., Boutron-Ruault, M. -C, Buring, J. E., Gaziano, J. M., Giovannucci, E. L., Duell, E. J., Hallmans, Göran, Howard, B. V., Hunter, D. J., Hutchinson, A., Jacobs, K. B., Kooperberg, C., Kraft, P., Mendelsohn, J. B., Michaud, D. S., Palli, D., Phillips, L. S., Overvad, K., Patel, A. V., Sansbury, L., Shu, X. -O, Simon, M. S., Slimani, N., Trichopoulos, D., Visvanathan, K., Virtamo, J., Wolpin, B. M., Zeleniuch-Jacquotte, A., Fuchs, C. S., Hoover, R. N., and Gross, M.
Abstract: Purpose: Diabetes is a suspected risk factor for pancreatic cancer, but questions remain about whether it is a risk factor or a result of the disease. This study prospectively examined the association between diabetes and the risk of pancreatic adenocarcinoma in pooled data from the NCI pancreatic cancer cohort consortium (PanScan). Methods: The pooled data included 1,621 pancreatic adenocarcinoma cases and 1,719 matched controls from twelve cohorts using a nested case-control study design. Subjects who were diagnosed with diabetes near the time (<2 years) of pancreatic cancer diagnosis were excluded from all analyses. All analyses were adjusted for age, race, gender, study, alcohol use, smoking, BMI, and family history of pancreatic cancer. Results: Self-reported diabetes was associated with a forty percent increased risk of pancreatic cancer (OR = 1.40, 95 % CI: 1.07, 1.84). The association differed by duration of diabetes; risk was highest for those with a duration of 2-8 years (OR = 1.79, 95 % CI: 1.25, 2.55); there was no association for those with 9+ years of diabetes (OR = 1.02, 95 % CI: 0.68, 1.52). Conclusions: These findings provide support for a relationship between diabetes and pancreatic cancer risk. The absence of association in those with the longest duration of diabetes may reflect hypoinsulinemia and warrants further investigation.
Published: 2013
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49. Integrating gene expression and epidemiological data for the discovery of genetic interactions associated with cancer risk

Author: Bonifaci, N., primary, Colas, E., additional, Serra-Musach, J., additional, Karbalai, N., additional, Brunet, J., additional, Gomez, A., additional, Esteller, M., additional, Fernandez-Taboada, E., additional, Berenguer, A., additional, Reventos, J., additional, Muller-Myhsok, B., additional, Amundadottir, L., additional, Duell, E. J., additional, and Pujana, M. A., additional
Published: 2013
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50. The association of pattern of lifetime alcohol use and cause of death in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Author: Bergmann, M. M., primary, Rehm, J., additional, Klipstein-Grobusch, K., additional, Boeing, H., additional, Schutze, M., additional, Drogan, D., additional, Overvad, K., additional, Tjonneland, A., additional, Halkjaer, J., additional, Fagherazzi, G., additional, Boutron-Ruault, M.-C., additional, Clavel-Chapelon, F., additional, Teucher, B., additional, Kaaks, R., additional, Trichopoulou, A., additional, Benetou, V., additional, Trichopoulos, D., additional, Palli, D., additional, Pala, V., additional, Tumino, R., additional, Vineis, P., additional, Beulens, J. W., additional, Redondo, M. L., additional, Duell, E. J., additional, Molina-Montes, E., additional, Navarro, C., additional, Barricarte, A., additional, Arriola, L., additional, Allen, N. E., additional, Crowe, F. L., additional, Khaw, K.-T., additional, Wareham, N., additional, Romaguera, D., additional, Wark, P. A., additional, Romieu, I., additional, Nunes, L., additional, Riboli, E., additional, and Ferrari, P., additional
Published: 2013
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