Search

Your search keyword '"Dudziński, Marek"' showing total 135 results
Start Over Author "Dudziński, Marek"
135 results on '"Dudziński, Marek"'

1. Does a Multiple Myeloma Polygenic Risk Score Predict Overall Survival of Patients with Myeloma?

Author

Macauda, Angelica, Clay-Gilmour, Alyssa, Hielscher, Thomas, Hildebrandt, Michelle, Kruszewski, Marcin, Orlowski, Robert, Kumar, Shaji, Ziv, Elad, Orciuolo, Enrico, Brown, Elizabeth, Försti, Asta, Waller, Rosalie, Machiela, Mitchell, Chanock, Stephen, Camp, Nicola, Rymko, Marcin, Raźny, Małgorzata, Cozen, Wendy, Várkonyi, Judit, Piredda, Chiara, Pelosini, Matteo, Belachew, Alem, Subocz, Edyta, Hemminki, Kari, Rybicka-Ramos, Malwina, Giles, Graham, Milne, Roger, Hofmann, Jonathan, Zaucha, Jan, Vangsted, Annette, Goldschmidt, Hartmut, Rajkumar, S, Tomczak, Waldemar, Sainz, Juan, Butrym, Aleksandra, Watek, Marzena, Iskierka-Jazdzewska, Elżbieta, Buda, Gabriele, Robinson, Dennis, Jurczyszyn, Artur, Dudziński, Marek, Martinez-Lopez, Joaquin, Sinnwell, Jason, Slager, Susan, Jamroziak, Krzysztof, Reis, Rui, Weinhold, Niels, Bhatti, Parveen, Carvajal-Carmona, Luis, Zawirska, Daria, Norman, Aaron, Mazur, Grzegorz, Berndt, Sonja, Campa, Daniele, Vachon, Celine, and Canzian, Federico

Subjects
Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Multiple Myeloma, Polymorphism, Single Nucleotide, Risk Factors
Abstract

BACKGROUND: Genome-wide association studies (GWAS) of multiple myeloma in populations of European ancestry (EA) identified and confirmed 24 susceptibility loci. For other cancers (e.g., colorectum and melanoma), risk loci have also been associated with patient survival. METHODS: We explored the possible association of all the known risk variants and their polygenic risk score (PRS) with multiple myeloma overall survival (OS) in multiple populations of EA [the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the International Lymphoma Epidemiology consortium, CoMMpass, and the German GWAS] for a total of 3,748 multiple myeloma cases. Cox proportional hazards regression was used to assess the association between each risk SNP with OS under the allelic and codominant models of inheritance. All analyses were adjusted for age, sex, country of origin (for IMMEnSE) or principal components (for the others) and disease stage (ISS). SNP associations were meta-analyzed. RESULTS: SNP associations were meta-analyzed. From the meta-analysis, two multiple myeloma risk SNPs were associated with OS (P < 0.05), specifically POT1-AS1-rs2170352 [HR = 1.37; 95% confidence interval (CI) = 1.09-1.73; P = 0.007] and TNFRSF13B-rs4273077 (HR = 1.19; 95% CI = 1.01-1.41; P = 0.04). The association between the combined 24 SNP MM-PRS and OS, however, was not significant. CONCLUSIONS: Overall, our results did not support an association between the majority of multiple myeloma risk SNPs and OS. IMPACT: This is the first study to investigate the association between multiple myeloma PRS and OS in multiple myeloma.

Published
2022

3. A polygenic risk score for multiple myeloma risk prediction

Author

Canzian, Federico, Piredda, Chiara, Macauda, Angelica, Zawirska, Daria, Andersen, Niels Frost, Nagler, Arnon, Zaucha, Jan Maciej, Mazur, Grzegorz, Dumontet, Charles, Wątek, Marzena, Jamroziak, Krzysztof, Sainz, Juan, Várkonyi, Judit, Butrym, Aleksandra, Beider, Katia, Abildgaard, Niels, Lesueur, Fabienne, Dudziński, Marek, Vangsted, Annette Juul, Pelosini, Matteo, Subocz, Edyta, Petrini, Mario, Buda, Gabriele, Raźny, Małgorzata, Gemignani, Federica, Marques, Herlander, Orciuolo, Enrico, Kadar, Katalin, Jurczyszyn, Artur, Druzd-Sitek, Agnieszka, Vogel, Ulla, Andersen, Vibeke, Reis, Rui Manuel, Suska, Anna, Avet-Loiseau, Hervé, Kruszewski, Marcin, Tomczak, Waldemar, Rymko, Marcin, Minvielle, Stephane, and Campa, Daniele

Published
2022
Full Text
View/download PDF

5. Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients.

Author

Dean, Eric, Hu, Donglei, Martino, Alessandro, Serie, Daniel, Curtin, Karen, Campa, Daniele, Aftab, Blake, Bracci, Paige, Buda, Gabriele, Zhao, Yi, Caswell-Jin, Jennifer, Diasio, Robert, Dumontet, Charles, Dudziński, Marek, Greenberg, Alexandra, Huntsman, Scott, Jamroziak, Krzysztof, Jurczyszyn, Artur, Kumar, Shaji, Atanackovic, Djordje, Glenn, Martha, Cannon-Albright, Lisa, Jones, Brandt, Lee, Adam, Marques, Herlander, Martin, Thomas, Martinez-Lopez, Joaquin, Rajkumar, Vincent, Sainz, Juan, Vangsted, Annette, Wątek, Marzena, Wolf, Jeffrey, Slager, Susan, Camp, Nicola, Canzian, Federico, Vachon, Celine, Ziv, Elad, and Fejerman, Laura

Subjects
Chromosomes, Human, Pair 16, Genome-Wide Association Study, Humans, Kaplan-Meier Estimate, Multiple Myeloma, Polymorphism, Single Nucleotide
Abstract

Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI: 1.94-3.58) relative to patients homozygous for the major allele. We replicate the association in the IMMEnSE cohort including 772 patients, and a University of Utah cohort including 318 patients (rs72773978 P=0.044). Using publicly available data, we find that the minor allele was associated with increased expression of FOPNL and increased expression of FOPNL was associated with higher expression of centrosomal genes and with shorter survival. Polymorphisms at the FOPNL locus are associated with survival among MM patients.

Published
2015

6. Genetically determined telomere length and multiple myeloma risk and outcome

Author

Giaccherini, Matteo, Macauda, Angelica, Orciuolo, Enrico, Rymko, Marcin, Gruenpeter, Karolina, Dumontet, Charles, Raźny, Malgorzata, Moreno, Victor, Buda, Gabriele, Beider, Katia, Varkonyi, Judit, Avet-Loiseau, Hervé, Martinez-Lopez, Joaquín, Marques, Herlander, Watek, Marzena, Sarasquete, Maria Eugenia, Andersen, Vibeke, Karlin, Lionel, Suska, Anna, Kruszewski, Marcin, Abildgaard, Niels, Dudziński, Marek, Butrym, Aleksandra, Nagler, Arnold, Vangsted, Annette Juul, Kadar, Katalin, Waldemar, Tomczak, Jamroziak, Krzysztof, Jacobsen, Svend Erik Hove, Ebbesen, Lene Hyldahl, Taszner, Michał, Mazur, Grzegorz, Lesueur, Fabienne, Pelosini, Matteo, Garcia-Sanz, Ramon, Jurczyszyn, Artur, Demangel, Delphine, Reis, Rui Manuel, Iskierka-Jażdżewska, Elżbieta, Markiewicz, Miroslaw, Gemignani, Federica, Subocz, Edyta, Zawirska, Daria, Druzd-Sitek, Agnieszka, Stępień, Anna, Alonso, M. Henar, Sainz, Juan, Canzian, Federico, and Campa, Daniele

Published
2021
Full Text
View/download PDF

7. Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma

Author

Pertesi, Maroulio, Vallée, Maxime, Wei, Xiaomu, Revuelta, Maria V., Galia, Perrine, Demangel, Delphine, Oliver, Javier, Foll, Matthieu, Chen, Siwei, Perrial, Emeline, Garderet, Laurent, Corre, Jill, Leleu, Xavier, Boyle, Eileen M., Decaux, Olivier, Rodon, Philippe, Kolb, Brigitte, Slama, Borhane, Mineur, Philippe, Voog, Eric, Le Bris, Catherine, Fontan, Jean, Maigre, Michel, Beaumont, Marie, Azais, Isabelle, Sobol, Hagay, Vignon, Marguerite, Royer, Bruno, Perrot, Aurore, Fuzibet, Jean-Gabriel, Dorvaux, Véronique, Anglaret, Bruno, Cony-Makhoul, Pascale, Berthou, Christian, Desquesnes, Florence, Pegourie, Brigitte, Leyvraz, Serge, Mosser, Laurent, Frenkiel, Nicole, Augeul-Meunier, Karine, Leduc, Isabelle, Leyronnas, Cécile, Voillat, Laurent, Casassus, Philippe, Mathiot, Claire, Cheron, Nathalie, Paubelle, Etienne, Moreau, Philippe, Bignon, Yves–Jean, Joly, Bertrand, Bourquard, Pascal, Caillot, Denis, Naman, Hervé, Rigaudeau, Sophie, Marit, Gérald, Macro, Margaret, Lambrecht, Isabelle, Cliquennois, Manuel, Vincent, Laure, Helias, Philippe, Avet-Loiseau, Hervé, Moreno, Victor, Reis, Rui Manuel, Varkonyi, Judit, Kruszewski, Marcin, Vangsted, Annette Juul, Jurczyszyn, Artur, Zaucha, Jan Maciej, Sainz, Juan, Krawczyk-Kulis, Malgorzata, Wątek, Marzena, Pelosini, Matteo, Iskierka-Jażdżewska, Elzbieta, Grząśko, Norbert, Martinez-Lopez, Joaquin, Jerez, Andrés, Campa, Daniele, Buda, Gabriele, Lesueur, Fabienne, Dudziński, Marek, García-Sanz, Ramón, Nagler, Arnon, Rymko, Marcin, Jamroziak, Krzysztof, Butrym, Aleksandra, Canzian, Federico, Obazee, Ofure, Nilsson, Björn, Klein, Robert J., Lipkin, Steven M., McKay, James D., and Dumontet, Charles

Published
2019
Full Text
View/download PDF

8. Supporting the Diagnosis of Fabry Disease Using a Natural Language Processing-Based Approach

Author

Michalski, Adrian A., primary, Lis, Karol, additional, Stankiewicz, Joanna, additional, Kloska, Sylwester M., additional, Sycz, Arkadiusz, additional, Dudziński, Marek, additional, Muras-Szwedziak, Katarzyna, additional, Nowicki, Michał, additional, Bazan-Socha, Stanisława, additional, Dabrowski, Michal J., additional, and Basak, Grzegorz W., additional

Published
2023
Full Text
View/download PDF

9. Analiza skuteczności ibrutynibu w podgrupie chorych na przewlekłą białaczkę limfocytową z delecją 17p: badanie obserwacyjne Polskiej Grupy ds. Leczenia Białaczek u Dorosłych (PALG)

Author

Puła, Bartosz, Iskierka-Jażdżewska, Elżbieta, Hus, Marek, Szymczyk, Agnieszka, Gołos, Aleksandra, Piotrowska, Magdalena, Zawirska, Daria, Zaucha, Jan Maciej, Steckiewicz, Paweł, Pasiarski, Marcin, Chraniuk, Dominik, Piszczek, Weronika, Osowiecki, Michał, Subocz, Edyta, Hałka, Janusz, Waszczuk-Gajda, Anna, Drozd-Sokołowska, Joanna, Knopińska-Posłuszny, Wanda, Dudziński, Marek, Hołojda, Jadwiga, Wojciechowska, Małgorzata, Kulikowski, Waldemar, Szeremet, Agnieszka, Kumiega, Beata, Pluta, Andrzej, Markiewicz, Mirosław, Giannopoulos, Krzysztof, Robak, Tadeusz, Warzocha, Krzysztof, and Jamroziak, Krzysztof

Published
2017
Full Text
View/download PDF

10. A pleiotropic variant in DNAJB4 is associated with multiple myeloma risk

Author

Dicanio, Marco, Giaccherini, Matteo, Clay-Gilmour, Alyssa, Macauda, Angelica, Sainz, Juan, Machiela, Mitchell J., Rybicka-Ramos, Malwina, Norman, Aaron D., Tyczyńska, Agata, Chanock, Stephen J., Barington, Torben, Kumar, Shaji K., Bhatti, Parveen, Cozen, Wendy, Brown, Elizabeth E., Suska, Anna, Haastrup, Eva K., Orlowski, Robert Z., Dudziński, Marek, Garcia-Sanz, Ramon, Kruszewski, Marcin, Martinez-Lopez, Joaquin, Beider, Katia, Iskierka-Jazdzewska, Elżbieta, Pelosini, Matteo, Berndt, Sonja I., Raźny, Małgorzata, Jamroziak, Krzysztof, Rajkumar, S. Vincent, Jurczyszyn, Artur, Vangsted, Annette Juul, Collado, Pilar Garrido, Vogel, Ulla, Hofmann, Jonathan N., Petrini, Mario, Butrym, Aleksandra, Slager, Susan L., Ziv, Elad, Subocz, Edyta, Giles, Graham G., Andersen, Niels Frost, Mazur, Grzegorz, Watek, Marzena, Lesueur, Fabienne, Hildebrandt, Michelle A.T., Zawirska, Daria, Ebbesen, Lene Hyldahl, Marques, Herlander, Gemignani, Federica, Dumontet, Charles, Várkonyi, Judit, Buda, Gabriele, Nagler, Arnon, Druzd-Sitek, Agnieszka, Wu, Xifeng, Kadar, Katalin, Camp, Nicola J., Grzasko, Norbert, Waller, Rosalie G., Vachon, Celine, Canzian, Federico, Campa, Daniele, Dicanio, Marco, Giaccherini, Matteo, Clay-Gilmour, Alyssa, Macauda, Angelica, Sainz, Juan, Machiela, Mitchell J., Rybicka-Ramos, Malwina, Norman, Aaron D., Tyczyńska, Agata, Chanock, Stephen J., Barington, Torben, Kumar, Shaji K., Bhatti, Parveen, Cozen, Wendy, Brown, Elizabeth E., Suska, Anna, Haastrup, Eva K., Orlowski, Robert Z., Dudziński, Marek, Garcia-Sanz, Ramon, Kruszewski, Marcin, Martinez-Lopez, Joaquin, Beider, Katia, Iskierka-Jazdzewska, Elżbieta, Pelosini, Matteo, Berndt, Sonja I., Raźny, Małgorzata, Jamroziak, Krzysztof, Rajkumar, S. Vincent, Jurczyszyn, Artur, Vangsted, Annette Juul, Collado, Pilar Garrido, Vogel, Ulla, Hofmann, Jonathan N., Petrini, Mario, Butrym, Aleksandra, Slager, Susan L., Ziv, Elad, Subocz, Edyta, Giles, Graham G., Andersen, Niels Frost, Mazur, Grzegorz, Watek, Marzena, Lesueur, Fabienne, Hildebrandt, Michelle A.T., Zawirska, Daria, Ebbesen, Lene Hyldahl, Marques, Herlander, Gemignani, Federica, Dumontet, Charles, Várkonyi, Judit, Buda, Gabriele, Nagler, Arnon, Druzd-Sitek, Agnieszka, Wu, Xifeng, Kadar, Katalin, Camp, Nicola J., Grzasko, Norbert, Waller, Rosalie G., Vachon, Celine, Canzian, Federico, and Campa, Daniele

Abstract

Pleiotropy, which consists of a single gene or allelic variant affecting multiple unrelated traits, is common across cancers, with evidence for genome-wide significant loci shared across cancer and noncancer traits. This feature is particularly relevant in multiple myeloma (MM) because several susceptibility loci that have been identified to date are pleiotropic. Therefore, the aim of this study was to identify novel pleiotropic variants involved in MM risk using 28 684 independent single nucleotide polymorphisms (SNPs) from GWAS Catalog that reached a significant association (P < 5 × 10−8) with their respective trait. The selected SNPs were analyzed in 2434 MM cases and 3446 controls from the International Lymphoma Epidemiology Consortium (InterLymph). The 10 SNPs showing the strongest associations with MM risk in InterLymph were selected for replication in an independent set of 1955 MM cases and 1549 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium and 418 MM cases and 147 282 controls from the FinnGen project. The combined analysis of the three studies identified an association between DNAJB4-rs34517439-A and an increased risk of developing MM (OR = 1.22, 95%CI 1.13-1.32, P = 4.81 × 10−7). rs34517439-A is associated with a modified expression of the FUBP1 gene, which encodes a multifunctional DNA and RNA-binding protein that it was observed to influence the regulation of various genes involved in cell cycle regulation, among which various oncogenes and oncosuppressors. In conclusion, with a pleiotropic scan approach we identified DNAJB4-rs34517439 as a potentially novel MM risk locus.

Published
2023

11. A pleiotropic variant in DNAJB4 is associated with multiple myeloma risk

Author

Università di Pisa, German Cancer Research Center, Dicanio, Marco, Giaccherini, Matteo, Clay-Gilmour, Alyssa, Macauda, Angelica, Sainz, Juan, Machiela, Mitchell J., Rybicka-Ramos, Malwina, Norman, Aaron D., Tyczyńska, Agata, Chanock, Stephen J., Barington, Torben, Kumar, Shaji K., Bhatti, Parveen, Cozen, Wendy, Brown, Elizabeth E., Suska, Anna, Haastrup, Eva K., Orlowski, R. Z., Dudziński, Marek, García-Sanz, Ramón, Kruszewski, Marcin, Martínez-López, Joaquín, Beider, Katia, Iskierka-Jazdzewska, Elżbieta, Pelosini, Matteo, Berndt, Sonja, Raźny, Małgorzata, Jamroziak, Krzysztof, Rajkumar, S. Vincent, Jurczyszyn, Artur, Vangsted, Annette Juul, Garrido, Pilar, Vogel, Ulla, Hofmann, Jonathan N., Petrini, Mario, Butrym, Aleksandra, Slager, Susan L., Ziv, Elad, Subocz, Edyta, Giles, Graham G., Frost Andersen, Niels, Mazur, Grzegorz, Watek, Marzena, Lesueur, Fabienne, Hildebrandt, Michelle A. T., Zawirska, Daria, Hyldahl Ebbesen, Lene, Marques, Herlander, Gemignani, Federica, Dumontet, Charles, Várkonyi, Judit, Buda, Gabriele, Nagler, Arnon, Druzd-Sitek, Agnieszka, Wu, Xifeng, Kadar, Katalin, Camp, Nicola J., Grzasko, Norbert, Waller, Rosalie G., Vachon, Celine, Canzian, Federico, Campa, Daniele, Università di Pisa, German Cancer Research Center, Dicanio, Marco, Giaccherini, Matteo, Clay-Gilmour, Alyssa, Macauda, Angelica, Sainz, Juan, Machiela, Mitchell J., Rybicka-Ramos, Malwina, Norman, Aaron D., Tyczyńska, Agata, Chanock, Stephen J., Barington, Torben, Kumar, Shaji K., Bhatti, Parveen, Cozen, Wendy, Brown, Elizabeth E., Suska, Anna, Haastrup, Eva K., Orlowski, R. Z., Dudziński, Marek, García-Sanz, Ramón, Kruszewski, Marcin, Martínez-López, Joaquín, Beider, Katia, Iskierka-Jazdzewska, Elżbieta, Pelosini, Matteo, Berndt, Sonja, Raźny, Małgorzata, Jamroziak, Krzysztof, Rajkumar, S. Vincent, Jurczyszyn, Artur, Vangsted, Annette Juul, Garrido, Pilar, Vogel, Ulla, Hofmann, Jonathan N., Petrini, Mario, Butrym, Aleksandra, Slager, Susan L., Ziv, Elad, Subocz, Edyta, Giles, Graham G., Frost Andersen, Niels, Mazur, Grzegorz, Watek, Marzena, Lesueur, Fabienne, Hildebrandt, Michelle A. T., Zawirska, Daria, Hyldahl Ebbesen, Lene, Marques, Herlander, Gemignani, Federica, Dumontet, Charles, Várkonyi, Judit, Buda, Gabriele, Nagler, Arnon, Druzd-Sitek, Agnieszka, Wu, Xifeng, Kadar, Katalin, Camp, Nicola J., Grzasko, Norbert, Waller, Rosalie G., Vachon, Celine, Canzian, Federico, and Campa, Daniele

Abstract

Pleiotropy, which consists of a single gene or allelic variant affecting multiple unrelated traits, is common across cancers, with evidence for genome-wide significant loci shared across cancer and noncancer traits. This feature is particularly relevant in multiple myeloma (MM) because several susceptibility loci that have been identified to date are pleiotropic. Therefore, the aim of this study was to identify novel pleiotropic variants involved in MM risk using 28 684 independent single nucleotide polymorphisms (SNPs) from GWAS Catalog that reached a significant association (P < 5 × 10−8) with their respective trait. The selected SNPs were analyzed in 2434 MM cases and 3446 controls from the International Lymphoma Epidemiology Consortium (InterLymph). The 10 SNPs showing the strongest associations with MM risk in InterLymph were selected for replication in an independent set of 1955 MM cases and 1549 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium and 418 MM cases and 147 282 controls from the FinnGen project. The combined analysis of the three studies identified an association between DNAJB4-rs34517439-A and an increased risk of developing MM (OR = 1.22, 95%CI 1.13-1.32, P = 4.81 × 10−7). rs34517439-A is associated with a modified expression of the FUBP1 gene, which encodes a multifunctional DNA and RNA-binding protein that it was observed to influence the regulation of various genes involved in cell cycle regulation, among which various oncogenes and oncosuppressors. In conclusion, with a pleiotropic scan approach we identified DNAJB4-rs34517439 as a potentially novel MM risk locus.

Published
2023

13. A pleiotropic variant in DNAJB4 is associated with multiple myeloma risk

Author

Dicanio, Marco, primary, Giaccherini, Matteo, additional, Clay‐Gilmour, Alyssa, additional, Macauda, Angelica, additional, Sainz, Juan, additional, Machiela, Mitchell J., additional, Rybicka‐Ramos, Malwina, additional, Norman, Aaron D., additional, Tyczyńska, Agata, additional, Chanock, Stephen J., additional, Barington, Torben, additional, Kumar, Shaji K., additional, Bhatti, Parveen, additional, Cozen, Wendy, additional, Brown, Elizabeth E., additional, Suska, Anna, additional, Haastrup, Eva K., additional, Orlowski, Robert Z., additional, Dudziński, Marek, additional, Garcia‐Sanz, Ramon, additional, Kruszewski, Marcin, additional, Martinez‐Lopez, Joaquin, additional, Beider, Katia, additional, Iskierka‐Jazdzewska, Elżbieta, additional, Pelosini, Matteo, additional, Berndt, Sonja I., additional, Raźny, Małgorzata, additional, Jamroziak, Krzysztof, additional, Rajkumar, S. Vincent, additional, Jurczyszyn, Artur, additional, Vangsted, Annette Juul, additional, Collado, Pilar Garrido, additional, Vogel, Ulla, additional, Hofmann, Jonathan N., additional, Petrini, Mario, additional, Butrym, Aleksandra, additional, Slager, Susan L., additional, Ziv, Elad, additional, Subocz, Edyta, additional, Giles, Graham G., additional, Andersen, Niels Frost, additional, Mazur, Grzegorz, additional, Watek, Marzena, additional, Lesueur, Fabienne, additional, Hildebrandt, Michelle A. T., additional, Zawirska, Daria, additional, Ebbesen, Lene Hyldahl, additional, Marques, Herlander, additional, Gemignani, Federica, additional, Dumontet, Charles, additional, Várkonyi, Judit, additional, Buda, Gabriele, additional, Nagler, Arnon, additional, Druzd‐Sitek, Agnieszka, additional, Wu, Xifeng, additional, Kadar, Katalin, additional, Camp, Nicola J., additional, Grzasko, Norbert, additional, Waller, Rosalie G., additional, Vachon, Celine, additional, Canzian, Federico, additional, and Campa, Daniele, additional

Published
2022
Full Text
View/download PDF

14. Identification of miRSNPs associated with the risk of multiple myeloma

Author

Macauda, Angelica, Calvetti, Diego, Maccari, Giuseppe, Hemminki, Kari, Försti, Asta, Goldschmidt, Hartmut, Weinhold, Niels, Houlston, Richard, Andersen, Vibeke, Vogel, Ulla, Buda, Gabriele, Varkonyi, Judit, Sureda, Anna, Martinez Lopez, Joaquin, Watek, Marzena, Butrym, Aleksandra, Sarasquete, Maria Eugenia, Dudziński, Marek, Jurczyszyn, Artur, DruzdSitek, Agnieszka, Kruszewski, Marcin, Subocz, Edyta, Petrini, Mario, IskierkaJażdżewska, Elzbieta, Raźny, Malgorzata, Szombath, Gergely, Marques, Herlander, Zawirska, Daria, Chraniuk, Dominik, Halka, Janusz, Hove Jacobsen, Svend Erik, Mazur, Grzegorz, García Sanz, Ramón, Dumontet, Charles, Moreno, Victor, Stępień, Anna, Beider, Katia, Pelosini, Matteo, Manuel Reis, Rui, KrawczykKulis, Malgorzata, Rymko, Marcin, AvetLoiseau, Hervé, Lesueur, Fabienne, Grząśko, Norbert, Ostrovsky, Olga, Jamroziak, Krzysztof, Vangsted, Annette J., Jerez, Andrés, Tomczak, Waldemar, Zaucha, Jan Maciej, Kadar, Katalin, Sainz, Juan, Nagler, Arnon, Landi, Stefano, Gemignani, Federica, and Canzian, Federico

Published
2017
Full Text
View/download PDF

16. Polish Experts’ Position Statement on the use of granulocyte colony-stimulating factor in the treatment of chronic lymphocytic leukemia with venetoclax combined with rituximab

Author

Iskierka-Jażdżewska, Elżbieta, primary, Giannopoulos, Krzysztof, additional, Grosicki, Sebastian, additional, Jamroziak, Krzysztof, additional, Wróbel, Tomasz, additional, Zaucha, Jan Maciej, additional, Dudziński, Marek, additional, Bołkuń, Łukasz, additional, Bodzenta, Ewa, additional, Drozd-Sokołowska, Joanna, additional, Samborska, Agnieszka, additional, Wolska-Washer, Anna, additional, and Hus, Iwona, additional

Published
2021
Full Text
View/download PDF

17. A polygenic risk score for multiple myeloma risk prediction

Author

Canzian, Federico, primary, Piredda, Chiara, additional, Macauda, Angelica, additional, Zawirska, Daria, additional, Andersen, Niels Frost, additional, Nagler, Arnon, additional, Zaucha, Jan Maciej, additional, Mazur, Grzegorz, additional, Dumontet, Charles, additional, Wątek, Marzena, additional, Jamroziak, Krzysztof, additional, Sainz, Juan, additional, Várkonyi, Judit, additional, Butrym, Aleksandra, additional, Beider, Katia, additional, Abildgaard, Niels, additional, Lesueur, Fabienne, additional, Dudziński, Marek, additional, Vangsted, Annette Juul, additional, Pelosini, Matteo, additional, Subocz, Edyta, additional, Petrini, Mario, additional, Buda, Gabriele, additional, Raźny, Małgorzata, additional, Gemignani, Federica, additional, Marques, Herlander, additional, Orciuolo, Enrico, additional, Kadar, Katalin, additional, Jurczyszyn, Artur, additional, Druzd-Sitek, Agnieszka, additional, Vogel, Ulla, additional, Andersen, Vibeke, additional, Reis, Rui Manuel, additional, Suska, Anna, additional, Avet-Loiseau, Hervé, additional, Kruszewski, Marcin, additional, Tomczak, Waldemar, additional, Rymko, Marcin, additional, Minvielle, Stephane, additional, and Campa, Daniele, additional

Published
2021
Full Text
View/download PDF

18. Risk of multiple myeloma is associated with polymorphisms within telomerase genes and telomere length

Author

Campa, Daniele, Martino, Alessandro, Varkonyi, Judit, Lesueur, Fabienne, Jamroziak, Krzysztof, Landi, Stefano, Jurczyszyn, Artur, Marques, Herlander, Andersen, Vibeke, Jurado, Manuel, Brenner, Hermann, Petrini, Mario, Vogel, Ulla, García-Sanz, Ramón, Buda, Gabriele, Gemignani, Federica, Ríos, Rafael, Vangsted, Annette Juul, Dumontet, Charles, Martínez-López, Joaquín, Moreno, María José, Stępień, Anna, Wątek, Marzena, Moreno, Victor, Dieffenbach, Aida Karina, Rossi, Anna Maria, Butterbach, Katja, Jacobsen, Svend E. Hove, Goldschmidt, Hartmut, Sainz, Juan, Hillengass, Jens, Orciuolo, Enrico, Dudziński, Marek, Weinhold, Niels, Reis, Rui Manuel, and Canzian, Federico

Published
2015
Full Text
View/download PDF

19. Common gene variants within 3′-untranslated regions as modulators of multiple myeloma risk and survival

Author

Melaiu, Ombretta, Macauda, Angelica, Sainz, Juan, Calvetti, Diego, Facioni, Maria Sole, Maccari, Giuseppe, ter Horst, Rob, Netea, Mihai G., Li, Yang, Grząśko, Norbert, Moreno, Victor, Jurczyszyn, Artur, Jerez, Andrés, Watek, Marzena, Varkonyi, Judit, Garcia-Sanz, Ramon, Kruszewski, Marcin, Dudziński, Marek, Kadar, Katalin, Jacobsen, Svend Erik Hove, Mazur, Grzegorz, Andersen, Vibeke, Rybicka, Malwina, Zawirska, Daria, Raźny, Malgorzata, Zaucha, Jan Maciej, Ostrovsky, Olga, Iskierka-Jazdzewska, Elzbieta, Reis, Rui Manuel, Stępień, Anna, Beider, Katia, Nagler, Arnon, Druzd-Sitek, Agnieszka, Marques, Herlander, Martìnez-Lopez, Joaquin, Lesueur, Fabienne, Avet-Loiseau, Hervé, Vangsted, Annette Juul, Krawczyk-Kulis, Malgorzata, Butrym, Aleksandra, Jamroziak, Krzysztof, Dumontet, Charles, Vogel, Ulla, Rymko, Marcin, Pelosini, Matteo, Subocz, Edyta, Szombath, Gergely, Sarasquete, Maria Eugenia, Silvestri, Roberto, Morani, Federica, Landi, Stefano, Campa, Daniele, Canzian, Federico, Gemignani, Federica, Melaiu, Ombretta, Macauda, Angelica, Sainz, Juan, Calvetti, Diego, Facioni, Maria Sole, Maccari, Giuseppe, ter Horst, Rob, Netea, Mihai G., Li, Yang, Grząśko, Norbert, Moreno, Victor, Jurczyszyn, Artur, Jerez, Andrés, Watek, Marzena, Varkonyi, Judit, Garcia-Sanz, Ramon, Kruszewski, Marcin, Dudziński, Marek, Kadar, Katalin, Jacobsen, Svend Erik Hove, Mazur, Grzegorz, Andersen, Vibeke, Rybicka, Malwina, Zawirska, Daria, Raźny, Malgorzata, Zaucha, Jan Maciej, Ostrovsky, Olga, Iskierka-Jazdzewska, Elzbieta, Reis, Rui Manuel, Stępień, Anna, Beider, Katia, Nagler, Arnon, Druzd-Sitek, Agnieszka, Marques, Herlander, Martìnez-Lopez, Joaquin, Lesueur, Fabienne, Avet-Loiseau, Hervé, Vangsted, Annette Juul, Krawczyk-Kulis, Malgorzata, Butrym, Aleksandra, Jamroziak, Krzysztof, Dumontet, Charles, Vogel, Ulla, Rymko, Marcin, Pelosini, Matteo, Subocz, Edyta, Szombath, Gergely, Sarasquete, Maria Eugenia, Silvestri, Roberto, Morani, Federica, Landi, Stefano, Campa, Daniele, Canzian, Federico, and Gemignani, Federica

Abstract

We evaluated the association between germline genetic variants located within the 3′-untranlsated region (polymorphic 3′UTR, ie, p3UTR) of candidate genes involved in multiple myeloma (MM). We performed a case-control study within the International Multiple Myeloma rESEarch (IMMEnSE) consortium, consisting of 3056 MM patients and 1960 controls recruited from eight countries. We selected p3UTR of six genes known to act in different pathways relevant in MM pathogenesis, namely KRAS (rs12587 and rs7973623), VEGFA (rs10434), SPP1 (rs1126772), IRF4 (rs12211228) and IL10 (rs3024496). We found that IL10-rs3024496 was associated with increased risk of developing MM and with a worse overall survival of MM patients. The variant allele was assayed in a vector expressing eGFP chimerized with the IL10 3′-UTR and it was found functionally active following transfection in human myeloma cells. In this experiment, the A-allele caused a lower expression of the reporter gene and this was also in agreement with the in vivo expression of mRNA measured in whole blood as reported in the GTEx portal. Overall, these data are suggestive of an effect of the IL10-rs3024496 SNP on the regulation of IL10 mRNA expression and it could have clinical implications for better characterization of MM patients in terms of prognosis.

Published
2021

21. Expression quantitative trait loci of genes predicting outcome are associated with survival of multiple myeloma patients

Author

Macauda, Angelica, primary, Piredda, Chiara, additional, Clay‐Gilmour, Alyssa I., additional, Sainz, Juan, additional, Buda, Gabriele, additional, Markiewicz, Miroslaw, additional, Barington, Torben, additional, Ziv, Elad, additional, Hildebrandt, Michelle A. T., additional, Belachew, Alem A., additional, Varkonyi, Judit, additional, Prejzner, Witold, additional, Druzd‐Sitek, Agnieszka, additional, Spinelli, John, additional, Andersen, Niels Frost, additional, Hofmann, Jonathan N., additional, Dudziński, Marek, additional, Martinez‐Lopez, Joaquin, additional, Iskierka‐Jazdzewska, Elzbieta, additional, Milne, Roger L., additional, Mazur, Grzegorz, additional, Giles, Graham G., additional, Ebbesen, Lene Hyldahl, additional, Rymko, Marcin, additional, Jamroziak, Krzysztof, additional, Subocz, Edyta, additional, Reis, Rui Manuel, additional, Garcia‐Sanz, Ramon, additional, Suska, Anna, additional, Haastrup, Eva Kannik, additional, Zawirska, Daria, additional, Grzasko, Norbert, additional, Vangsted, Annette Juul, additional, Dumontet, Charles, additional, Kruszewski, Marcin, additional, Dutka, Magdalena, additional, Camp, Nicola J., additional, Waller, Rosalie G., additional, Tomczak, Waldemar, additional, Pelosini, Matteo, additional, Raźny, Małgorzata, additional, Marques, Herlander, additional, Abildgaard, Niels, additional, Wątek, Marzena, additional, Jurczyszyn, Artur, additional, Brown, Elizabeth E., additional, Berndt, Sonja, additional, Butrym, Aleksandra, additional, Vachon, Celine M., additional, Norman, Aaron D., additional, Slager, Susan L., additional, Gemignani, Federica, additional, Canzian, Federico, additional, and Campa, Daniele, additional

Published
2021
Full Text
View/download PDF

22. A polygenic risk score for multiple myeloma risk prediction:E-poster

Author

Macauda, Angelica, Canzian, Federico, Piredda, Chiara, Zawirska, Daria, Andersen, Niels Frost, Nagler, Arnon, Zaucha, Jan Maciej, Mazur, Grzegorz, Dumontet, Charles, Wątek, Marzena, Jamroziak, Krzysztof, Sainz, Juan, Várkonyi, Judit, Butrym , Aleksandra, Beider, Katia, Abildgaard, Niels, Lesueur, Fabienne, Dudziński, Marek, Vangsted, Annette Juul, Pelosini, Matteo, Subocz, Edyta, Petrini, Mario, Buda, Gabriele, Raźny, Małgorzata, Gemignani, Federica, Marques, Herlander, Orciuolo, Enrico, Kadar, Katalin, J. Jurczyszyn, Artur, Druzd-Sitek, Agnieszka, Vogel, Ulla, Andersen, Vibeke, Reis, Rui Manuel, Suska, Anna, Avet-Loiseau, Hervé, Kruszewski, Marcin, Tomczak, Waldemar, Rymko, Marcin, Stephane Minvielle, Stephane, and Campa, Daniele

Published
2020

23. Common gene variants within 3′‐untranslated regions as modulators of multiple myeloma risk and survival

Author

Melaiu, Ombretta, primary, Macauda, Angelica, additional, Sainz, Juan, additional, Calvetti, Diego, additional, Facioni, Maria Sole, additional, Maccari, Giuseppe, additional, Horst, Rob, additional, Netea, Mihai G., additional, Li, Yang, additional, Grząśko, Norbert, additional, Moreno, Victor, additional, Jurczyszyn, Artur, additional, Jerez, Andrés, additional, Watek, Marzena, additional, Varkonyi, Judit, additional, Garcia‐Sanz, Ramon, additional, Kruszewski, Marcin, additional, Dudziński, Marek, additional, Kadar, Katalin, additional, Jacobsen, Svend Erik Hove, additional, Mazur, Grzegorz, additional, Andersen, Vibeke, additional, Rybicka, Malwina, additional, Zawirska, Daria, additional, Raźny, Malgorzata, additional, Zaucha, Jan Maciej, additional, Ostrovsky, Olga, additional, Iskierka‐Jazdzewska, Elzbieta, additional, Reis, Rui Manuel, additional, Stępień, Anna, additional, Beider, Katia, additional, Nagler, Arnon, additional, Druzd‐Sitek, Agnieszka, additional, Marques, Herlander, additional, Martìnez‐Lopez, Joaquin, additional, Lesueur, Fabienne, additional, Avet‐Loiseau, Hervé, additional, Vangsted, Annette Juul, additional, Krawczyk‐Kulis, Malgorzata, additional, Butrym, Aleksandra, additional, Jamroziak, Krzysztof, additional, Dumontet, Charles, additional, Vogel, Ulla, additional, Rymko, Marcin, additional, Pelosini, Matteo, additional, Subocz, Edyta, additional, Szombath, Gergely, additional, Sarasquete, Maria Eugenia, additional, Silvestri, Roberto, additional, Morani, Federica, additional, Landi, Stefano, additional, Campa, Daniele, additional, Canzian, Federico, additional, and Gemignani, Federica, additional

Published
2020
Full Text
View/download PDF

24. Cereblon (CRBN) gene polymorphisms predict clinical response and progression-free survival in relapsed/refractory multiple myeloma patients treated with lenalidomide: a pharmacogenetic study from the IMMEnSE consortium

Author

Iskierka-Jażdżewska, Elżbieta, primary, Canzian, Federico, additional, Stępień, Anna, additional, Martino, Alessandro, additional, Campa, Daniele, additional, Stein, Angelica, additional, Krawczyk-Kuliś, Małgorzata, additional, Rybicka-Ramos, Malwina, additional, Kyrcz-Krzemień, Sławomira, additional, Butrym, Aleksandra, additional, Mazur, Grzegorz, additional, Jurczyszyn, Artur, additional, Zawirska, Daria, additional, Grząśko, Norbert, additional, Tomczak, Waldemar, additional, Subocz, Edyta, additional, Wątek, Marzena, additional, Pasiarski, Marcin, additional, Rymko, Marcin, additional, Całbecka, Małgorzata, additional, Druzd-Sitek, Agnieszka, additional, Walewski, Jan, additional, Kruszewski, Marcin, additional, Raźny, Małgorzata, additional, Zaucha, Jan Maciej, additional, Dudziński, Marek, additional, Gaj, Paweł, additional, Robak, Tadeusz, additional, Warzocha, Krzysztof, additional, and Jamroziak, Krzysztof, additional

Published
2019
Full Text
View/download PDF

25. Exome sequencing identifies germline variants in DIS3 in familial multiple myeloma.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Pertesi, Maroulio, Vallée, Maxime, Wei, Xiaomu, Revuelta, Maria V, Galia, Perrine, Demangel, Delphine, Oliver, Javier, Foll, Matthieu, Chen, Siwei, Perrial, Emeline, Garderet, Laurent, Corre, Jill, Leleu, Xavier, Boyle, Eileen M, Decaux, Olivier, Rodon, Philippe, Kolb, Brigitte, Slama, Borhane, Mineur, Philippe, Voog, Eric, Le Bris, Catherine, Fontan, Jean, Maigre, Michel, Beaumont, Marie, Azais, Isabelle, Sobol, Hagay, Vignon, Marguerite, Royer, Bruno, Perrot, Aurore, Fuzibet, Jean-Gabriel, Dorvaux, Véronique, Anglaret, Bruno, Cony-Makhoul, Pascale, Berthou, Christian, Desquesnes, Florence, Pegourie, Brigitte, Leyvraz, Serge, Mosser, Laurent, Frenkiel, Nicole, Augeul-Meunier, Karine, Leduc, Isabelle, Leyronnas, Cécile, Voillat, Laurent, Casassus, Philippe, Mathiot, Claire, Cheron, Nathalie, Paubelle, Etienne, Moreau, Philippe, Bignon, Yves-Jean, Joly, Bertrand, Bourquard, Pascal, Caillot, Denis, Naman, Hervé, Rigaudeau, Sophie, Marit, Gérald, Macro, Margaret, Lambrecht, Isabelle, Cliquennois, Manuel, Vincent, Laure, Helias, Philippe, Avet-Loiseau, Hervé, Moreno, Victor, Reis, Rui Manuel, Varkonyi, Judit, Kruszewski, Marcin, Vangsted, Annette Juul, Jurczyszyn, Artur, Zaucha, Jan Maciej, Sainz, Juan, Krawczyk-Kulis, Malgorzata, Wątek, Marzena, Pelosini, Matteo, Iskierka-Jażdżewska, Elzbieta, Grząśko, Norbert, Martinez-Lopez, Joaquin, Jerez, Andrés, Campa, Daniele, Buda, Gabriele, Lesueur, Fabienne, Dudziński, Marek, García-Sanz, Ramón, Nagler, Arnon, Rymko, Marcin, Jamroziak, Krzysztof, Butrym, Aleksandra, Canzian, Federico, Obazee, Ofure, Nilsson, Björn, Klein, Robert J, Lipkin, Steven M, McKay, James D, Dumontet, Charles, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service d'hématologie, Pertesi, Maroulio, Vallée, Maxime, Wei, Xiaomu, Revuelta, Maria V, Galia, Perrine, Demangel, Delphine, Oliver, Javier, Foll, Matthieu, Chen, Siwei, Perrial, Emeline, Garderet, Laurent, Corre, Jill, Leleu, Xavier, Boyle, Eileen M, Decaux, Olivier, Rodon, Philippe, Kolb, Brigitte, Slama, Borhane, Mineur, Philippe, Voog, Eric, Le Bris, Catherine, Fontan, Jean, Maigre, Michel, Beaumont, Marie, Azais, Isabelle, Sobol, Hagay, Vignon, Marguerite, Royer, Bruno, Perrot, Aurore, Fuzibet, Jean-Gabriel, Dorvaux, Véronique, Anglaret, Bruno, Cony-Makhoul, Pascale, Berthou, Christian, Desquesnes, Florence, Pegourie, Brigitte, Leyvraz, Serge, Mosser, Laurent, Frenkiel, Nicole, Augeul-Meunier, Karine, Leduc, Isabelle, Leyronnas, Cécile, Voillat, Laurent, Casassus, Philippe, Mathiot, Claire, Cheron, Nathalie, Paubelle, Etienne, Moreau, Philippe, Bignon, Yves-Jean, Joly, Bertrand, Bourquard, Pascal, Caillot, Denis, Naman, Hervé, Rigaudeau, Sophie, Marit, Gérald, Macro, Margaret, Lambrecht, Isabelle, Cliquennois, Manuel, Vincent, Laure, Helias, Philippe, Avet-Loiseau, Hervé, Moreno, Victor, Reis, Rui Manuel, Varkonyi, Judit, Kruszewski, Marcin, Vangsted, Annette Juul, Jurczyszyn, Artur, Zaucha, Jan Maciej, Sainz, Juan, Krawczyk-Kulis, Malgorzata, Wątek, Marzena, Pelosini, Matteo, Iskierka-Jażdżewska, Elzbieta, Grząśko, Norbert, Martinez-Lopez, Joaquin, Jerez, Andrés, Campa, Daniele, Buda, Gabriele, Lesueur, Fabienne, Dudziński, Marek, García-Sanz, Ramón, Nagler, Arnon, Rymko, Marcin, Jamroziak, Krzysztof, Butrym, Aleksandra, Canzian, Federico, Obazee, Ofure, Nilsson, Björn, Klein, Robert J, Lipkin, Steven M, McKay, James D, and Dumontet, Charles

Abstract

To the Editor, Multiple myeloma (MM) is the third most common hematological malignancy, after Non-Hodgkin Lymphoma and Leukemia. MM is generally preceded by Monoclonal Gammopathy of Undetermined Significance (MGUS) [1], and epidemiological studies have identified older age, male gender, family history, and MGUS as risk factors for developing MM [...]

Published
2019

26. Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival:an IMMEnSE study

Author

Campa, Daniele, Martino, Alessandro, Macauda, Angelica, Dudziński, Marek, Suska, Anna, Druzd-Sitek, Agnieszka, Raab, Marc-Steffen, Moreno, Victor, Huhn, Stefanie, Butrym, Aleksandra, Sainz, Juan, Szombath, Gergely, Rymko, Marcin, Marques, Herlander, Lesueur, Fabienne, Vangsted, Annette Juul, Vogel, Ulla, Kruszewski, Marcin, Subocz, Edyta, Buda, Gabriele, Iskierka-Jażdżewska, Elżbieta, Ríos, Rafael, Merz, Maximilian, Schöttker, Ben, Mazur, Grzegorz, Perrial, Emeline, Martinez-Lopez, Joaquin, Butterbach, Katja, García Sanz, Ramón, Goldschmidt, Hartmut, Brenner, Hermann, Jamroziak, Krzysztof, Reis, Rui Manuel, Kadar, Katalin, Dumontet, Charles, Wątek, Marzena, Haastrup, Eva Kannik, Helbig, Grzegorz, Jurczyszyn, Artur, Jerez, Andrés, Varkonyi, Judit, Barington, Torben, Grzasko, Norbert, Zaucha, Jan Maciej, Andersen, Vibeke, Zawirska, Daria, Canzian, Federico, Campa, Daniele, Martino, Alessandro, Macauda, Angelica, Dudziński, Marek, Suska, Anna, Druzd-Sitek, Agnieszka, Raab, Marc-Steffen, Moreno, Victor, Huhn, Stefanie, Butrym, Aleksandra, Sainz, Juan, Szombath, Gergely, Rymko, Marcin, Marques, Herlander, Lesueur, Fabienne, Vangsted, Annette Juul, Vogel, Ulla, Kruszewski, Marcin, Subocz, Edyta, Buda, Gabriele, Iskierka-Jażdżewska, Elżbieta, Ríos, Rafael, Merz, Maximilian, Schöttker, Ben, Mazur, Grzegorz, Perrial, Emeline, Martinez-Lopez, Joaquin, Butterbach, Katja, García Sanz, Ramón, Goldschmidt, Hartmut, Brenner, Hermann, Jamroziak, Krzysztof, Reis, Rui Manuel, Kadar, Katalin, Dumontet, Charles, Wątek, Marzena, Haastrup, Eva Kannik, Helbig, Grzegorz, Jurczyszyn, Artur, Jerez, Andrés, Varkonyi, Judit, Barington, Torben, Grzasko, Norbert, Zaucha, Jan Maciej, Andersen, Vibeke, Zawirska, Daria, and Canzian, Federico

Abstract

Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence the risk of developing multiple myeloma (MM). During B-cell maturation, several programmed genetic rearrangements occur to increase the variation of the immunoglobulin chains. Class switch recombination (CSR) is one of the most important among these mechanisms. Germline polymorphisms altering even subtly this process could play a role in the etiology and outcome of MM. We performed an association study of 30 genetic variants in the key CSR genes, using 2632 MM patients and 2848 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the Heidelberg MM Group and the ESTHER cohort. We found an association between LIG4-rs1555902 and decreased MM risk, which approached statistical significance, as well as significant associations between AICDA-rs3794318 and better outcome. Our results add to our knowledge on the genetic component of MM risk and survival.

Published
2019

27. Efficacy and safety of obinutuzumab-chlorambucil combination in the frontline treatment of elderly patients with chronic lymphocytic leukemia and comorbidities : real‑life data from Polish Adult Leukemia Group (PALG) analysis

Author

Długosz-Danecka, Monika, Jurczak, Wojciech, Łątka-Cabała, Ewa, Morawska, Marta, Gawroński, Krzysztof, Wiśniewska, Anna, Dudziński, Marek, Wąsik-Szczepanek, Ewa, Chmielowska, Ewa, Łabędź, Anna, Wdowiak, Kamil, and Hus, Iwona

Subjects
obinutuzumab, Cumulative Illness Rating Scale, hemic and lymphatic diseases, chronic lymphocytic leukemia, comorbidities
Abstract

Fludarabine- or bendamustine‑based upfront immunochemotherapy is the current standard of care in fit patients with chronic lymphocytic leukemia (CLL). These regimens are poorly tolerated by patients with comorbidities, for whom the obinutuzumab-chlorambucil combination became the recommended first‑line treatment. We aimed to analyze real‑life experience with the obinutuzumab-chlorambucil combination as the frontline treatment in elderly and unfit patients. The retrospective analysis included 86 elderly patients (median age, 74 years) with CLL and a significant burden of comorbidities, treated with obinutuzumab-chlorambucil as the frontline regimen. All patients had a Cumulative Illness Rating Scale score greater than 6 and/or creatinine clearance of 30 to 69 ml/min. Overall response rate at 2 months after treatment completion was 95.3%, with complete remission (CR) rate of 43% and partial remission (PR) rate of 52.3%. Stable disease rate was 4.7%. Progressive disease was not observed after treatment completion. The median progression‑free survival (PFS) was not reached after a median follow‑up of 18 months; estimated PFS at 30 months was 62%. We observed 6 relapses (7%), 3 (3.5%) in patients obtaining CR, and 3 (3.5%) in those with PR after immunochemotherapy. The most frequent adverse events were neutropenia and infusion‑related reactions (IRRs). Grade-3 neutropenia occurred in 11.6% of patients, and grade-3 IRRs, in 2.3%. There were no adverse events of grade 4 or 5. Our data confirm that the obinutuzumab-chlorambucil combination is an effective and well‑tolerated regimen in untreated CLL patients with comorbidities.

Published
2018

29. Ruksolitynib w terapii chorych na mielofibrozę — pytania i odpowiedzi

Author

Warzocha, Krzysztof, primary, Homenda, Wojciech, additional, Pluta, Andrzej, additional, Sacha, Tomasz, additional, Cioch, Maria, additional, Dudziński, Marek, additional, Krochmalczyk, Dorota, additional, Góra-Tybor, Joanna, additional, Seferyńska, Ilona, additional, Joks, Monika, additional, and Sobas, Marta, additional

Published
2019
Full Text
View/download PDF

30. Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study

Author

Campa, Daniele, primary, Martino, Alessandro, additional, Macauda, Angelica, additional, Dudziński, Marek, additional, Suska, Anna, additional, Druzd-Sitek, Agnieszka, additional, Raab, Marc-Steffen, additional, Moreno, Victor, additional, Huhn, Stefanie, additional, Butrym, Aleksandra, additional, Sainz, Juan, additional, Szombath, Gergely, additional, Rymko, Marcin, additional, Marques, Herlander, additional, Lesueur, Fabienne, additional, Vangsted, Annette Juul, additional, Vogel, Ulla, additional, Kruszewski, Marcin, additional, Subocz, Edyta, additional, Buda, Gabriele, additional, Iskierka-Jażdżewska, Elżbieta, additional, Ríos, Rafael, additional, Merz, Maximilian, additional, Schöttker, Ben, additional, Mazur, Grzegorz, additional, Perrial, Emeline, additional, Martinez-Lopez, Joaquin, additional, Butterbach, Katja, additional, García Sanz, Ramón, additional, Goldschmidt, Hartmut, additional, Brenner, Hermann, additional, Jamroziak, Krzysztof, additional, Reis, Rui Manuel, additional, Kadar, Katalin, additional, Dumontet, Charles, additional, Wątek, Marzena, additional, Haastrup, Eva Kannik, additional, Helbig, Grzegorz, additional, Jurczyszyn, Artur, additional, Jerez, Andrés, additional, Varkonyi, Judit, additional, Barington, Torben, additional, Grzasko, Norbert, additional, Zaucha, Jan Maciej, additional, Andersen, Vibeke, additional, Zawirska, Daria, additional, and Canzian, Federico, additional

Published
2019
Full Text
View/download PDF

31. Inherited variation in the xenobiotic transporter pathway and survival of multiple myeloma patients

Author

Macauda, Angelica, Castelli, Eleonora, Buda, Gabriele, Pelosini, Matteo, Butrym, Aleksandra, Watek, Marzena, Kruszewski, Marcin, Vangsted, Annette Juul, Rymko, Marcin, Jamroziak, Krzysztof, Abildgaard, Niels, Haastrup, Eva Kannik, Mazur, Grzegorz, Ríos, Rafael, Jurczyszyn, Artur, Zawirska, Daria, Dudziński, Marek, Raźny, Małgorzata, Dutka, Magdalena, Tomczak, Waldemar, Suska, Anna, Druzd-Sitek, Agnieszka, Marques, Herlander, Petrini, Mario, Markiewicz, Miroslaw, Martinez-Lopez, Joaquin, Ebbesen, Lene Hyldahl, Iskierka-Jażdżewska, Elżbieta, Sainz, Juan, Canzian, Federico, Campa, Daniele, Macauda, Angelica, Castelli, Eleonora, Buda, Gabriele, Pelosini, Matteo, Butrym, Aleksandra, Watek, Marzena, Kruszewski, Marcin, Vangsted, Annette Juul, Rymko, Marcin, Jamroziak, Krzysztof, Abildgaard, Niels, Haastrup, Eva Kannik, Mazur, Grzegorz, Ríos, Rafael, Jurczyszyn, Artur, Zawirska, Daria, Dudziński, Marek, Raźny, Małgorzata, Dutka, Magdalena, Tomczak, Waldemar, Suska, Anna, Druzd-Sitek, Agnieszka, Marques, Herlander, Petrini, Mario, Markiewicz, Miroslaw, Martinez-Lopez, Joaquin, Ebbesen, Lene Hyldahl, Iskierka-Jażdżewska, Elżbieta, Sainz, Juan, Canzian, Federico, and Campa, Daniele

Abstract

Over the past four decades, remarkable progress has been made in the treatment and prognosis of multiple myeloma (MM), although it remains an incurable disease. Chemotherapy resistance is a major hurdle for treatment efficacy. Drug resistance can be innate and so driven by genes involved in the drug metabolism pathways. We performed an association study of 71 germline variants within the major genes in those pathways (ABCB1, ABCC2, ABCG2, and their regulators NR1I2/PXR and NR1I3/CAR) in the International Multiple Myeloma rESEarch (IMMEnSE) consortium, consisting of 1365 MM cases with survival information recruited in 5 European countries. Two of the SNPs showed a significant association with the survival of MM patients, namely rs2235013, located in ABCB1 [Hazard ratio (HR) = 1·52, 95% confidence interval (CI) = 1·18-1·95, P = 0·00087], and rs4148388, located in ABCC2 (HR = 2·15, 95% CI = 1·44-3·22, P = 0·0001). ABCC2 plays an essential role in transporting various anticancer drugs, including several used against MM, out of the cell. In silico analyses predict that the variant alleles of four SNPs in linkage disequilibrium with ABCC2-rs4148388 are associated with increased gene expression. Overexpression of ABCC2 increases drug clearance and therefore may induce drug resistance mechanisms. In conclusion, we found a promising association between ABCC2-rs4148388 and MM outcome that is supported by a plausible biological explanation.

Published
2018

34. Inherited variation in the xenobiotic transporter pathway and survival of multiple myeloma patients

Author

Macauda, Angelica, primary, Castelli, Eleonora, additional, Buda, Gabriele, additional, Pelosini, Matteo, additional, Butrym, Aleksandra, additional, Watek, Marzena, additional, Kruszewski, Marcin, additional, Vangsted, Annette Juul, additional, Rymko, Marcin, additional, Jamroziak, Krzysztof, additional, Abildgaard, Niels, additional, Haastrup, Eva Kannik, additional, Mazur, Grzegorz, additional, Ríos, Rafael, additional, Jurczyszyn, Artur, additional, Zawirska, Daria, additional, Dudziński, Marek, additional, Raźny, Małgorzata, additional, Dutka, Magdalena, additional, Tomczak, Waldemar, additional, Suska, Anna, additional, Druzd-Sitek, Agnieszka, additional, Marques, Herlander, additional, Petrini, Mario, additional, Markiewicz, Miroslaw, additional, Martinez-Lopez, Joaquin, additional, Ebbesen, Lene Hyldahl, additional, Iskierka-Jażdżewska, Elżbieta, additional, Sainz, Juan, additional, Canzian, Federico, additional, and Campa, Daniele, additional

Published
2018
Full Text
View/download PDF

35. Efficacy and safety of the obinutuzumab-chlorambucil combination in the frontline treatment of elderly CLL patients with comorbidities – Polish Adult Leukemia Group (PALG) real-life analysis

Author

Długosz-Danecka, Monika, primary, Jurczak, Wojciech, additional, Łątka-Cabała, Ewa, additional, Morawska, Marta, additional, Gawroński, Krzysztof, additional, Wiśniewska, Anna, additional, Dudziński, Marek, additional, Wąsik-Szczepanek, Ewa, additional, Chmielowska, Ewa, additional, Łabędź, Anna, additional, Wdowiak, Kamil, additional, and Hus, Iwona, additional

Published
2018
Full Text
View/download PDF

36. Praktyka kliniczna oceny minimalnej choroby resztkowej u chorych na szpiczaka plazmocytowego w Polsce: badanie ankietowe Polskiego Konsorcjum Szpiczakowego

Author

Krzywdzińska, Agnieszka, primary, Solarska, Iwona, additional, Puła, Bartosz, additional, Czyż, Anna, additional, Dytfeld, Dominik, additional, Jurczyszyn, Artur, additional, Giannopoulos, Krzysztof, additional, Balana-Nowak, Agnieszka, additional, Własiuk, Paulina, additional, Waszczuk-Gajda, Anna, additional, Król, Maria, additional, Dudziński, Marek, additional, Burdacki, Adrian, additional, Wróbel, Tomasz, additional, Szymczak, Donata, additional, Jankowska-Łęcka, Olga, additional, Bernatowicz, Paweł, additional, Zaucha, Jan, additional, Tyczyńska, Agata, additional, Druzd-Sitek, Agnieszka, additional, Centkowski, Piotr, additional, Świderska, Alina, additional, Elżbieta, Rutkowska, additional, Lewandowski, Krzysztof, additional, Warzocha, Krzysztof, additional, and Jamroziak, Krzysztof, additional

Published
2018
Full Text
View/download PDF

37. A multicenter prospective study on efficacy and safety of imatinib generics: A report from Polish Adult Leukemia Group imatinib generics registry

Author

Sacha, Tomasz, primary, Góra-Tybor, Joanna, additional, Szarejko, Monika, additional, Bober, Grażyna, additional, Grzybowska-Izydorczyk, Olga, additional, Niesiobędzka-Krężel, Joanna, additional, Dudziński, Marek, additional, Wasilewska, Ewa, additional, Myśliwiec, Krzysztof, additional, Gil, Justyna, additional, Gniot, Michał, additional, Pietkun, Iwona, additional, Mędraś, Ewa, additional, Hołojda, Jadwiga, additional, Wącław, Joanna, additional, and Giannopoulos, Krzysztof, additional

Published
2017
Full Text
View/download PDF

38. Efficacy and toxicity of compassionate ibrutinib use in relapsed/refractory chronic lymphocytic leukemia in Poland: analysis of the Polish Adult Leukemia Group (PALG)

Author

Iskierka-Jażdżewska, Elżbieta, primary, Hus, Marek, additional, Giannopoulos, Krzysztof, additional, Mądro, Elżbieta, additional, Hołojda, Jadwiga, additional, Piotrowska, Magdalena, additional, Zaucha, Jan M., additional, Piszczek, Weronika, additional, Szeremet, Agnieszka, additional, Wojciechowska, Małgorzata, additional, Steckiewicz, Paweł, additional, Knopińska-Posłuszny, Wanda, additional, Osowiecki, Marek, additional, Drozd-Sokołowska, Joanna, additional, Kumiega, Beata, additional, Kyrcz-Krzemień, Sławomira, additional, Hałka, Janusz, additional, Dudziński, Marek, additional, Wieszczy, Paulina, additional, Robak, Tadeusz, additional, Warzocha, Krzysztof, additional, and Jamroziak, Krzysztof, additional

Published
2017
Full Text
View/download PDF

39. Imatinib Generics in Treatment of Chronic Myeloid Leukemia; A Prospective Observation in Large Cohort of Patients from Polish (PALG) Imatinib Generics Registry

Author

Sacha, Tomasz, primary, Gora-Tybor, Joanna, additional, Szarejko, Monika, additional, Bober, Grażyna, additional, Grzybowska-Izydorczyk, Olga, additional, Niesiobędzka-Krężel, Joanna, additional, Dudziński, Marek, additional, Wasilewska, Ewa, additional, Myśliwiec, Krzysztof, additional, Gil, Justyna, additional, Gniot, Michał, additional, Pietkun, Iwona, additional, Mędraś, Ewa, additional, Wącław, Joanna, additional, and Giannopoulos, Krzysztof, additional

Published
2016
Full Text
View/download PDF

40. Identification of miRSNPs associated with the risk of multiple myeloma

Author

Macauda, Angelica, primary, Calvetti, Diego, additional, Maccari, Giuseppe, additional, Hemminki, Kari, additional, Försti, Asta, additional, Goldschmidt, Hartmut, additional, Weinhold, Niels, additional, Houlston, Richard, additional, Andersen, Vibeke, additional, Vogel, Ulla, additional, Buda, Gabriele, additional, Varkonyi, Judit, additional, Sureda, Anna, additional, Martinez Lopez, Joaquin, additional, Watek, Marzena, additional, Butrym, Aleksandra, additional, Sarasquete, Maria Eugenia, additional, Dudziński, Marek, additional, Jurczyszyn, Artur, additional, Druzd-Sitek, Agnieszka, additional, Kruszewski, Marcin, additional, Subocz, Edyta, additional, Petrini, Mario, additional, Iskierka-Jażdżewska, Elzbieta, additional, Raźny, Malgorzata, additional, Szombath, Gergely, additional, Marques, Herlander, additional, Zawirska, Daria, additional, Chraniuk, Dominik, additional, Halka, Janusz, additional, Hove Jacobsen, Svend Erik, additional, Mazur, Grzegorz, additional, García Sanz, Ramón, additional, Dumontet, Charles, additional, Moreno, Victor, additional, Stępień, Anna, additional, Beider, Katia, additional, Pelosini, Matteo, additional, Manuel Reis, Rui, additional, Krawczyk-Kulis, Malgorzata, additional, Rymko, Marcin, additional, Avet-Loiseau, Hervé, additional, Lesueur, Fabienne, additional, Grząśko, Norbert, additional, Ostrovsky, Olga, additional, Jamroziak, Krzysztof, additional, Vangsted, Annette J., additional, Jerez, Andrés, additional, Tomczak, Waldemar, additional, Zaucha, Jan Maciej, additional, Kadar, Katalin, additional, Sainz, Juan, additional, Nagler, Arnon, additional, Landi, Stefano, additional, Gemignani, Federica, additional, and Canzian, Federico, additional

Published
2016
Full Text
View/download PDF

41. Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients

Author

Ziv, Elad, Dean, Eric, Hu, Donglei, Martino, Alessandro, Serie, Daniel, Curtin, Karen, Campa, Daniele, Aftab, Blake, Bracci, Paige, Buda, Gabriele, Zhao, Yi, Caswell-Jin, Jennifer, Diasio, Robert, Dumontet, Charles, Dudziński, Marek, Fejerman, Laura, Greenberg, Alexandra, Huntsman, Scott, Jamroziak, Krzysztof, Jurczyszyn, Artur, Kumar, Shaji, Atanackovic, Djordje, Glenn, Martha, Cannon-Albright, Lisa A, Jones, Brandt, Lee, Adam, Marques, Herlander, Martin, Thomas, Martinez-Lopez, Joaquin, Rajkumar, Vincent, Sainz, Juan, Vangsted, Annette Juul, Wątek, Marzena, Wolf, Jeffrey, Slager, Susan, Camp, Nicola J, Canzian, Federico, Vachon, Celine, and Universidade do Minho

Subjects
Science & Technology, Ciências Médicas::Ciências da Saúde, Humans, Kaplan-Meier Estimate, Multiple Myeloma, Polymorphism, Single Nucleotide, Chromosomes, Human, Pair 16, Genome-Wide Association Study
Abstract

A corrigendum to this article was published on 09 December 2015: https://doi.org/10.1038/ncomms10203. The corrigendum is also available at: http://hdl.handle.net/1822/62281, Here we perform the first genome-wide association study (GWAS) of multiple myeloma (MM) survival. In a meta-analysis of 306 MM patients treated at UCSF and 239 patients treated at the Mayo clinic, we find a significant association between SNPs near the gene FOPNL on chromosome 16p13 and survival (rs72773978; P=6 × 10(-10)). Patients with the minor allele are at increased risk for mortality (HR: 2.65; 95% CI: 1.94-3.58) relative to patients homozygous for the major allele. We replicate the association in the IMMEnSE cohort including 772 patients, and a University of Utah cohort including 318 patients (rs72773978 P=0.044). Using publicly available data, we find that the minor allele was associated with increased expression of FOPNL and increased expression of FOPNL was associated with higher expression of centrosomal genes and with shorter survival. Polymorphisms at the FOPNL locus are associated with survival among MM patients., This work was supported by the Steve and Nancy Grand Multiple Myeloma Translational Initiative and a grant from Expression Analysis and a grant from the National Cancer Institute (R21CA191896). E.Z. is supported in part by a mid-career award in patient research from the National Cancer Institute (K24169004). Collection of blood samples from Polish patients and controls from Łodz area, and DNA extraction was supported by a grant from Polish Ministry of Science and Higher Education (No. NN402178334).DNA extraction from Danish healthy controls was supported by The Research Fund at Region Sjælland, Denmark. The Utah study was supported by LLS 6067–09, CA152336and CA134674, with data collection made possible, in part, by the Utah Population Database (UPDB) and the Utah Cancer Registry (UCR). Partial support for all data sets within the UPDB is provided by the Huntsman Cancer Institute (HCI) and the HCICancer Center Support grant, P30 CA42014. The UCR is supported in part by NIH contract HHSN261201000026C from the NCI SEER Program with additional support from the Utah State Department of Health and the University of Utah. In Utah, we thank Jathine Wong for support in formatting files and advice on R programming. Several authors (E.Z., N.C., F.C., C.V.) are members of the International Multiple Myeloma Consortium. We are grateful to the leadership and other members of the International Multiple Myeloma Consortium for facilitating this collaborative study.

Published
2015

43. Correction: Corrigendum: Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients

Author

Ziv, Elad, primary, Dean, Eric, additional, Hu, Donglei, additional, Martino, Alessandro, additional, Serie, Daniel, additional, Curtin, Karen, additional, Campa, Daniele, additional, Aftab, Blake, additional, Bracci, Paige, additional, Buda, Gabriele, additional, Zhao, Yi, additional, Caswell-Jin, Jennifer, additional, Diasio, Robert, additional, Dumontet, Charles, additional, Dudziński, Marek, additional, Fejerman, Laura, additional, Greenberg, Alexandra, additional, Huntsman, Scott, additional, Jamroziak, Krzysztof, additional, Jurczyszyn, Artur, additional, Kumar, Shaji, additional, Atanackovic, Djordje, additional, Glenn, Martha, additional, Cannon-Albright, Lisa A., additional, Jones, Brandt, additional, Lee, Adam, additional, Marques, Herlander, additional, Martin, Thomas, additional, Martinez-Lopez, Joaquin, additional, Rajkumar, Vincent, additional, Sainz, Juan, additional, Juul Vangsted, Annette, additional, Watek, Marzena, additional, Wolf, Jeffrey, additional, Slager, Susan, additional, Camp, Nicola J., additional, Canzian, Federico, additional, and Vachon, Celine, additional

Published
2015
Full Text
View/download PDF

45. Exome sequencing identifies germline variants in DIS3in familial multiple myeloma

Author

Pertesi, Maroulio, Vallée, Maxime, Wei, Xiaomu, Revuelta, Maria V., Galia, Perrine, Demangel, Delphine, Oliver, Javier, Foll, Matthieu, Chen, Siwei, Perrial, Emeline, Garderet, Laurent, Corre, Jill, Leleu, Xavier, Boyle, Eileen M., Decaux, Olivier, Rodon, Philippe, Kolb, Brigitte, Slama, Borhane, Mineur, Philippe, Voog, Eric, Le Bris, Catherine, Fontan, Jean, Maigre, Michel, Beaumont, Marie, Azais, Isabelle, Sobol, Hagay, Vignon, Marguerite, Royer, Bruno, Perrot, Aurore, Fuzibet, Jean-Gabriel, Dorvaux, Véronique, Anglaret, Bruno, Cony-Makhoul, Pascale, Berthou, Christian, Desquesnes, Florence, Pegourie, Brigitte, Leyvraz, Serge, Mosser, Laurent, Frenkiel, Nicole, Augeul-Meunier, Karine, Leduc, Isabelle, Leyronnas, Cécile, Voillat, Laurent, Casassus, Philippe, Mathiot, Claire, Cheron, Nathalie, Paubelle, Etienne, Moreau, Philippe, Bignon, Yves–Jean, Joly, Bertrand, Bourquard, Pascal, Caillot, Denis, Naman, Hervé, Rigaudeau, Sophie, Marit, Gérald, Macro, Margaret, Lambrecht, Isabelle, Cliquennois, Manuel, Vincent, Laure, Helias, Philippe, Avet-Loiseau, Hervé, Moreno, Victor, Reis, Rui Manuel, Varkonyi, Judit, Kruszewski, Marcin, Vangsted, Annette Juul, Jurczyszyn, Artur, Zaucha, Jan Maciej, Sainz, Juan, Krawczyk-Kulis, Malgorzata, Wątek, Marzena, Pelosini, Matteo, Iskierka-Jażdżewska, Elzbieta, Grząśko, Norbert, Martinez-Lopez, Joaquin, Jerez, Andrés, Campa, Daniele, Buda, Gabriele, Lesueur, Fabienne, Dudziński, Marek, García-Sanz, Ramón, Nagler, Arnon, Rymko, Marcin, Jamroziak, Krzysztof, Butrym, Aleksandra, Canzian, Federico, Obazee, Ofure, Nilsson, Björn, Klein, Robert J., Lipkin, Steven M., McKay, James D., and Dumontet, Charles

Published
2019
Full Text
View/download PDF

46. Genome-wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients

Author

Ziv, Elad, primary, Dean, Eric, additional, Hu, Donglei, additional, Martino, Alessandro, additional, Serie, Daniel, additional, Curtin, Karen, additional, Campa, Daniele, additional, Aftab, Blake, additional, Bracci, Paige, additional, Buda, Gabriele, additional, Zhao, Yi, additional, Caswell-Jin, Jennifer, additional, Diasio, Robert, additional, Dumontet, Charles, additional, Dudziński, Marek, additional, Fejerman, Laura, additional, Greenberg, Alexandra, additional, Huntsman, Scott, additional, Jamroziak, Krzysztof, additional, Jurczyszyn, Artur, additional, Kumar, Shaji, additional, Atanackovic, Djordje, additional, Glenn, Martha, additional, Cannon-Albright, Lisa A., additional, Jones, Brandt, additional, Lee, Adam, additional, Marques, Herlander, additional, Martin, Thomas, additional, Martinez-Lopez, Joaquin, additional, Rajkumar, Vincent, additional, Sainz, Juan, additional, Vangsted, Annette Juul, additional, Wątek, Marzena, additional, Wolf, Jeffrey, additional, Slager, Susan, additional, Camp, Nicola J., additional, Canzian, Federico, additional, and Vachon, Celine, additional

Published
2015
Full Text
View/download PDF

48. Type 2 Diabetes-Related Variants Influence on the Risk of Developing Multiple Myeloma: Results from the Immense Consortium

Author

Sainz, Juan, primary, Lupiañez, Carmen Belén, additional, Campa, Daniele, additional, Buda, Gabriele, additional, Moreno, Hernan Jose, additional, Dudziński, Marek, additional, Dumontet, Charles, additional, García-Sanz, Ramón, additional, Jamroziak, Krzysztof, additional, Jurczyszyn, Artur J., additional, Landi, Stefano, additional, Lesueur, Fabienne, additional, Marques, Herlander, additional, Martínez-López, Joaquín, additional, Moreno, Victor, additional, Petrini, Mario, additional, Reis, Rui Manuel, additional, Szemraj-Rogucka, Zofia, additional, Vangsted, Annette Juul, additional, Varkonyi, Judit, additional, Vogel, Ulla, additional, Wątek, Marzena, additional, Canzian, Federico, additional, and Rios, Rafael, additional

Published
2014
Full Text
View/download PDF

49. Praktyka kliniczna oceny minimalnej choroby resztkowej u chorych na szpiczaka plazmocytowego w Polsce: badanie ankietowe Polskiego Konsorcjum Szpiczakowego.

Author

Krzywdzińska, Agnieszka, Solarska, Iwona, Puła, Bartosz, Czyż, Anna, Dytfeld, Dominik, Jurczyszyn, Artur, Balana-Nowak, Agnieszka, Giannopoulos, Krzysztof, Własiuk, Paulina, Waszczuk-Gajda, Anna, Król, Maria, Dudziński, Marek, Burdacki, Adrian, Wróbel, Tomasz, Szymczak, Donata, Jankowska-Łęcka, Olga, Bernatowicz, Paweł, Zaucha, Jan, Tyczyńska, Agata, and Druzd-Sitek, Agnieszka

Published
2017
Full Text
View/download PDF

50. Abstract 5078: Genome wide association study identifies variants at 16p13 associated with survival in multiple myeloma patients

Author

Ziv, Elad, primary, Dean, Eric, additional, Hu, Donglei, additional, Martino, Alessandro, additional, Serie, Daniel, additional, Campa, Daniele, additional, Aftab, Blake, additional, Bracci, Paige, additional, Buda, Gabriele, additional, Caswell, Jennifer, additional, Dumontet, Charles, additional, Dudziński, Marek, additional, Fejerman, Laura, additional, Greenberg, Alexandra, additional, Hunstman, Scott, additional, Jurczyszyn, Artur, additional, Jamroziak, Krzysztof, additional, Kumar, Shaji, additional, Marques, Herlander, additional, Martin, Thomas, additional, Martinez-Lopez, Joaquin, additional, Rajkumar, Vincent, additional, Sainz, Juan, additional, Vangsted, Annette Juul, additional, Watek, Marzena, additional, Wolf, Jeffrey, additional, Slager, Susan, additional, Canzian, Federico, additional, and Vachon, Celine, additional

Published
2014
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results