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6. Analisi delle caratteristiche dei carcinomi d’intervallo e screening detected a 10 anni dall’attivazione del programma di screening mammografico regionale del Friuli Venezia-Giulia nella provincia di Trieste

Author

GIUDICI, FABIOLA, BORTUL, MARINA, ARNEZ, ZORAN MARIJ, COVA, MARIA ASSUNTA, RIZZARDI, CLARA, BOTTIN, CRISTINA, SCAGGIANTE, BRUNA, TORELLI, LUCIO, ZANCONATI, FABRIZIO, Tonutti, M., Perulli, A., Assante, M., Cressa, C., Perrone, R., Pravato, M., Makuc, E., Kus, S., Lorusso, A., Gasparini, C., Ober, E., Martellani, F., Biagi, C., Dudine, S., Bonazza, D., Pinamonti, M., Rozze, D., Bellio, G., Scomersi, S., Dell’Antonio, A., Martinolli, S., Renzi, N., Manara, M., Oblak, M., Dore, F., Vidali, C., Ceccherini, R., Dellach, C, Foladore, S., Dudine, L., Malagoli, M., Guglielmi, A., Bonazza, T., Reho, A., Lepre, L., Bradaschia, S., Danieli, L., Gregorich, P, Matarrese, M., Pesavento, V., Coppola, N., Gongolo, F, Franzo, A., Gobbato, M., Clagnan, E., Zanier, L., Delli Quadri, N., Pubblicazione on line, Giudici, Fabiola, Tonutti, M., Bortul, Marina, Arnez, ZORAN MARIJ, Perulli, A., Assante, M., Cressa, C., Perrone, R., Pravato, M., Makuc, E., Kus, S., Lorusso, A., Cova, MARIA ASSUNTA, Gasparini, C., Ober, E., Martellani, F., Rizzardi, Clara, Biagi, C., Bottin, Cristina, Dudine, S., Bonazza, D., Pinamonti, M., Rozze, D., Bellio, G., Scomersi, S., Dell’Antonio, A., Martinolli, S., Renzi, N., Manara, M., Oblak, M., Dore, F., Vidali, C., Ceccherini, R., Dellach, C, Foladore, S., Dudine, L., Malagoli, M., Guglielmi, A., Bonazza, T., Reho, A., Lepre, L., Bradaschia, S., Danieli, L., Gregorich, P, Matarrese, M., Pesavento, V., Scaggiante, Bruna, Torelli, Lucio, Coppola, N., Gongolo, F, Franzo, A., Gobbato, M., Clagnan, E., Zanier, L., Delli Quadri, N., and Zanconati, Fabrizio

Subjects
Breast Unit, Screening Mammografico, Carcinomi Intervallo
Abstract

l cancro di intervallo (CI) è un’entità patologica che viene descritta solo nell’ambito dei programmi di screening organizzato. Si intende per CI un carcinoma successivo ad un processo di screening negativo e comparso prima del passaggio di screening successivo. Qualsiasi sia la motivazione della loro genesi, i CI rappresentano un insuccesso del programma di screening che, in teoria, mira a diagnosticare tutti i carcinomi in fase di screening, e a non consentire la comparsa di CI. L’analisi dei CI (loro frequenza di comparsa nel tempo, caratteristiche morfologiche e cliniche, revisione della precedente mammografia di screening) è un momento fondamentale della valutazione di performance dello screening.Per questo motivo a 10 anni dall’attivazione del programma di Screening a Trieste, si è voluto confrontare i fattori prognostici dei carcinomi screening-detected (CSD) e dei (CI), alla luce dell’ampio dibattito in letteratura riguardo la maggior aggressività di questi ultimi.

Published
2016

7. Cyto-radiological disageement: management

Author

Zanconati, Fabrizio, Giudici, Fabiola, Bianco, Alberto, Bonifacio, Daniela, Bottin, Cristina, Dudine, S., Martellani, F., Ober, E., Romano, A., Zacchi, A., Pinamonti, Maurizio, Zandonà, L., AL OMOUSH, Tahseen, Tonutti, M., Bortul, Marina, Assante, A., Cova, MARIA ASSUNTA, Gasparini, C., Frezza, F., Bortolotto, M. P., Cressa, C., Perrone, R., Makuc, E., Petz, G., de Morpurgo, P. L., Torelli, Lucio, DI BONITO, Luigi, Zanconati, Fabrizio, Giudici, Fabiola, Bianco, Alberto, Bonifacio, Daniela, Bottin, Cristina, Dudine, S., Martellani, F., Ober, E., Romano, A., Zacchi, A., Pinamonti, Maurizio, Zandonà, L., AL OMOUSH, Tahseen, Tonutti, M., Bortul, Marina, Assante, A., Cova, MARIA ASSUNTA, Gasparini, C., Frezza, F., Bortolotto, M. P., Cressa, C., Perrone, R., Makuc, E., Petz, G., de Morpurgo, P. L., Torelli, Lucio, and DI BONITO, Luigi

Subjects
cyto-radiological correlation, breast cytology, diagnostic category, quality control, cyto-histological correlation
Abstract

In Trieste, pathologists have been actively involved in breast diagnostics working alongside radiologists in the sampling time in order to set up together the most adequate approach in case-solving basing on the clinical/radiological and rapid stain cytological findings. Based on our own experience we prefer, whenever possible, to use the fine needle aspiration sampling method (FNA), almost always under ultrasound guidance, even for palpable lesions, reserving tru-cut biopsy only for a limited number of cases and vacuum-assisted biopsy (VAB) only in not ultrasound detectable lesions (id: isolated microcalcifications). The collaboration between radiologist and pathologist is essential to correctly evaluate identified lesions: the more coincident the results of radiological and cytological exams are, the more accurate the final diagnosis will be. Nevertheless there are some cases in which radiology and cytology do not agree. We decided to reassess the entire database, focusing on the management of discrepant cases in the light of the final histological diagnosis for surgical-treated cases or referring to the follow-up exams in the cases that did not undergo surgery.

Published
2012

8. Breast cytology: reporting

Author

DI BONITO, LUIGI, BONIFACIO, DANIELA, AL OMOUSH, TAHSEEN, BONAZZA, DEBORAH, DE PELLEGRIN, ALESSANDRO, GIUDICI, FABIOLA, TORELLI, LUCIO, BORTUL, MARINA, ZANCONATI, FABRIZIO, Martellani F., Dudine S., Di Napoli M., Isidoro E., Ober E., Leonardo E., Romano A., Zacchi A., Haxhijmeri O., Petris M., Zandonà L., Bandiera V., Tonutti M., DI BONITO, Luigi, Martellani, F., Bonifacio, Daniela, Dudine, S., Di Napoli, M., Isidoro, E., Ober, E., Leonardo, E., Romano, A., Zacchi, A., AL OMOUSH, Tahseen, Bonazza, Deborah, DE PELLEGRIN, Alessandro, Haxhijmeri, O., Petris, M., Zandonà, L., Bandiera, V., Giudici, Fabiola, Torelli, Lucio, Bortul, Marina, Tonutti, M., and Zanconati, Fabrizio

Subjects
fine needle aspiration, breast lesions, diagnostic categories C1-C5, breast lesion
Abstract

Fine needle aspiration cytology (FNAC) is widely used as first choice approach for the definition of the radiologically dubious or sospicious cases to confim their benign origin. Trieste's Breast Unit has been using FNAC as first morphological investigation for many years, in particular in 2008-2009, it was used as first diagnostic approach for 1835 cases (88.6%) out of 2091. The use of five diagnostic categories in cytology reporting has found wide acceptance among radiologists and surgeons, because it allows to apply to each lesiod, a precise diagnostic/terapeutic pathway and it represents, in oir experience, an essential element of the report itself.

Published
2010

9. Unusual cytologic aspects of a primary bladder neoplasm

Author

Dudine, S., Di Napoli, M., Leonardo, E., Martellani, F., Romano, A., Zacchi, A., FABRIZIO ZANCONATI, Rosano, I., Slatich, G., Di Bonito, L., Dudine, S., Di Napoli, M., Leonardo, E., Martellani, F., Romano, A., Zacchi, A., Zanconati, Fabrizio, Rosano, I., Slatich, G., and DI BONITO, Luigi

Subjects
bladder cancer, immunohistochemistry, cyto-histological comparison
Published
2009

10. Role of ultrasound (US)-guided FNA of axillary lymph nodes in breast carcinoma screening detected. P363

Author

Zanconati, Fabrizio, Tonutti, F., Martellani, F., Bortul, Marina, Contessa, N., Dore, F., De Pellegrin, A., Di Napoli, M., Dudine, S., Haxhiymeri, O., Isidoro, E., Pellis, G., Romano, A., Sarcinella, D., Schiavon, I., Zacchi, A., DI BONITO, Luigi, Zanconati, Fabrizio, Tonutti, F., Martellani, F., Bortul, Marina, Contessa, N., Dore, F., De Pellegrin, A., Di Napoli, M., Dudine, S., Haxhiymeri, O., Isidoro, E., Pellis, G., Romano, A., Sarcinella, D., Schiavon, I., Zacchi, A., and DI BONITO, Luigi

Subjects
sentinel lymph node, Breast cancer screening, sentinel lymph nodes, FNA cytology
Abstract

Breast carcinoma's screening in Trieste's area detected 60 women with cancer (two of them with bilateral cisease) in 2008. Forty-eight cases were diagnosed only by FNA (C5), 12 by VAB/mammotome and two by Fine Needle biopsy after undeterminated cytology. Axillary lymph nodes US was performed in 62,9% (39) of cases. They had alle been diagnosed as malignant (C5) by rapid cytology during breast nodule aspiration. .... Our study outlines cyology's accuracy to define axillary nodes' status suggestin the possibility to extent US followed by aspiration cytology to all screening detected cases with U3/4 axillary nodes.

Published
2009

11. Breast Cytology

Author

DI BONITO, Luigi, Bonifacio, Daniela, Dudine, S., Leonardo, E., Martellani, F., Romano, A., Tonutti, M., Zacchi, A., Zanconati, Fabrizio, DI BONITO, Luigi, Bonifacio, Daniela, Dudine, S., Leonardo, E., Martellani, F., Romano, A., Tonutti, M., Zacchi, A., and Zanconati, Fabrizio

Subjects
breast cancer, fine needle aspiration, screening-program
Published
2009

12. Clinical significance of ASC-H in non menopausal, perimenopausal and postmenopausal women

Author

Di Napoli, M., Zanconati, Fabrizio, Isidoro, E., Bonifacio, Daniela, De Pellegrin, A., Dudine, S. Leonardo E., Romano, A., Sarcinella, D., Schiavon, I., DI BONITO, Luigi, Di Napoli, M., Zanconati, Fabrizio, Isidoro, E., Bonifacio, Daniela, De Pellegrin, A., Dudine, S. Leonardo E., Romano, A., Sarcinella, D., Schiavon, I., and DI BONITO, Luigi

Subjects
cervical cancer screening, ASC-H, menopausal status
Abstract

Our study

Published
2009

13. Rolo of ultrasound (US)-guided FNA of axillary lymph nodes in breast carcinoma screening detected

Author

ZANCONATI, FABRIZIO, BORTUL, MARINA, DORE, FRANCA, DI BONITO, LUIGI, TONUTTI M, MARTELLANI F, CONTESSA N, DE PELLEGRIN A, DI NAPOLI M, DUDINE S, HAXHIYMERI O, ISIDORO E, PELLIS G, ROMANO A, SARCINELLA D, SCHIAVON I, ZACCHI A, Zanconati, Fabrizio, Tonutti, M, Martellani, F, Bortul, Marina, Contessa, N, Dore, Franca, DE PELLEGRIN, A, DI NAPOLI, M, Dudine, S, Haxhiymeri, O, Isidoro, E, Pellis, G, Romano, A, Sarcinella, D, Schiavon, I, Zacchi, A, and DI BONITO, Luigi

Subjects
fine needle aspiration, breast carcinoma, axillary limph
Published
2009

14. An unusual case of 'C3' FNA of breast screening detected lesion with cytohistological and immunohistochemical correlaion

Author

Zanconati, Fabrizio, Leonardo, E., Martellani, F., Haxhiymeri, O., Bonifacio, Daniela, Dudine, S., Romano, A., Neves, B., Pellis, G., Zacchi, A., Tonutti, M., DI BONITO, Luigi, Zanconati, Fabrizio, Leonardo, E., Martellani, F., Haxhiymeri, O., Bonifacio, Daniela, Dudine, S., Romano, A., Neves, B., Pellis, G., Zacchi, A., Tonutti, M., and DI BONITO, Luigi

Subjects
brest screening program, breast cancer, immunohistochemestry
Abstract

Accordin to the guidelines ofBreast Unit of Trieste's Province (Italy) all the mammographic abnormalities and lesions with clinical symptoms must be submitted to echography and in presenc of a doubtful finiding they must be investigated with fine needle Aspiration (FNA)under ultrasound guidance. Core or aspiation biopsy is reserved instead for those cases with inconclusive (C3-C4)

Published
2009

15. Cito-histological correlation of ASC-H in five years period

Author

Zanconati, Fabrizio, Isidoro, E., Di Napoli, M., Dudine, S., Martellani, F., Romano, A., Rosano, I., Slatich, G., Ulcigrai, L., Zacchi, A., DI BONITO, Luigi, Zanconati, Fabrizio, Isidoro, E., Di Napoli, M., Dudine, S., Martellani, F., Romano, A., Rosano, I., Slatich, G., Ulcigrai, L., Zacchi, A., and DI BONITO, Luigi

Subjects
H-SIL, Cervical cancer screening Bethesda system, cytohistological correlatio
Abstract

Incidence of ASC-H has been reported to be 0.13-0,84% and SIL on follow-up biopsy ranged from 27 to 89%. This diagnosis is used for cases that show cellular abnormalities more marked than reactive changes but that fall short of a definitive diagnosis of HSIL. We used cyto histologic correlation to determe the clinical significance of ASC-H fron 2004 to 2008.Out of 77 709 Pap smears, 182 were ASC-H (0,23%). ....... The diagnosis of ASC-H is associatd with an appreciable risk of lesion, so the patiensts should undergo colposcopic and histologic assessment to toule out SIL. Negative biopsy review outlined doubtful cases were mainly squamous metaplasia.

Published
2009

16. Ruolo della citologia nel programma di screening mammografico

Author

DI BONITO, LUIGI, BONIFACIO, DANIELA, ZANCONATI, FABRIZIO, DUDINE S, LEONARDO E, MARTELLANI F, ROMANO A, TONUTTI M, TORELLI, LUCIO, DI BONITO, Luigi, Bonifacio, Daniela, Dudine, S, Leonardo, E, Martellani, F, Romano, A, Tonutti, M, Torelli, Lucio, and Zanconati, Fabrizio

Published
2008

17. Considerazioni sul rapporto costo/beneficio del protocollo istologico del linfonodo sentinella nello screening mammografico

Author

DE PELLEGRIN, A, Zanconati, Fabrizio, Bortul, M, Dell'Antonio, A, Borea, B, Pellis, G, Dore, F, Tonutti, M, Bonifacio, Daniela, Contessa, N, DI NAPOLI, M, Dudine, S, Sarcinella, D, Schiavon, I, Ober, E, Zacchi, A, DI BONITO, Luigi, DE PELLEGRIN, A, Zanconati, Fabrizio, Bortul, M, Dell'Antonio, A, Borea, B, Pellis, G, Dore, F, Tonutti, M, Bonifacio, Daniela, Contessa, N, DI NAPOLI, M, Dudine, S, Sarcinella, D, Schiavon, I, Ober, E, Zacchi, A, and DI BONITO, Luigi

Published
2008

18. Unditermined lesions (C3 and C4) in breast cancer screening programme and in daily routine

Author

ZANCONATI, FABRIZIO, BONIFACIO, DANIELA, DI BONITO, LUIGI, CONTESSA N, DI NAPOLI M, DUDINE S, ISIDORO E, MARTELLANI F, OBER E, ROMANO A, SARCINELLA D, SCHIAVON I, SLATICH G, ULCIGRAI L, ZACCHI A, Zanconati, Fabrizio, Bonifacio, Daniela, Contessa, N, DI NAPOLI, M, Dudine, S, Isidoro, E, Martellani, F, Ober, E, Romano, A, Sarcinella, D, Schiavon, I, Slatich, G, Ulcigrai, L, Zacchi, A, and DI BONITO, Luigi

Subjects
sospicious lesions C3-C4, brest cancer, fine needle aspiration
Abstract

C3 and C4 represent the grey zone of breast aspiration cytology; we performed a comparison between C3 and C4 cases detected in 1314 consecutiva patients undergoing fine-needle aspiration cytology in the last 2 years.

Published
2008

19. Ruolo della citologia agoaspirativa nella definizione delle tumefazioni sovraclaveari

Author

Ober, E, Bonifacio, Daniela, Contessa, N, DE PELLEGRIN, Alessandro, DI NAPOLI, M, Dudine, S, Isidoro, E, Leonardo, E, Martellani, F, Romano, A, Rosano, I, Sarcinella, D, Schiavon, I, Slatich, G, Zacchi, A, Zanconati, Fabrizio, DI BONITO, Luigi, Ober, E, Bonifacio, Daniela, Contessa, N, DE PELLEGRIN, Alessandro, DI NAPOLI, M, Dudine, S, Isidoro, E, Leonardo, E, Martellani, F, Romano, A, Rosano, I, Sarcinella, D, Schiavon, I, Slatich, G, Zacchi, A, Zanconati, Fabrizio, and DI BONITO, Luigi

Subjects
citologia agoaspirativa, tumefazioni sovraclaveari, diagnosi
Published
2008

20. Immunocytochemistry's role in detecting primary tumor site of malignant effusions

Author

DI BONITO, LUIGI, ZANCONATI, FABRIZIO, BONIFACIO, DANIELA, LEONARDO E, ROMANO A, DUDINE S, DI BONITO, Luigi, Leonardo, E, Zanconati, Fabrizio, Romano, A, Dudine, S, and Bonifacio, Daniela

Subjects
immunohistochemistry, malignant effusions
Abstract

Neoplastic cells detection in effusions is extremely important as this may give information regarding primary tumor site, when unknown, for cancer staging and for cancer recurrence in the follow-up of oncologic patients

Published
2008

21. Classificazione NMH in citologia tiroidea: contributo ad una migliore definizione delle lesioni dubbie

Author

Zanconati, Fabrizio, Romano, A, Sabato, N, Bonifacio, Daniela, Dudine, S, DI NAPOLI, M, Isidoro, E, Rosano, I, Slatich, G, Ulcigrai, L, Martellani, F, DI BONITO, Luigi, Zanconati, Fabrizio, Romano, A, Sabato, N, Bonifacio, Daniela, Dudine, S, DI NAPOLI, M, Isidoro, E, Rosano, I, Slatich, G, Ulcigrai, L, Martellani, F, and DI BONITO, Luigi

Subjects
Fine-needle aspiration, citologia, lesioni tiroidee, classificazione
Published
2007

22. Indicatori surrogati di possibile amplificazione di HER-2/neu nel carcinoma mammario in assenza di immunoreattività

Author

Zanconati, Fabrizio, Bonifacio, Daniela, Dudine, S, Schiavon, I, Romano, A, Martellani, F, Sarcinella, D, Ober, E, DE PELLEGRIN, A, DI BONITO, Luigi, Zanconati, Fabrizio, Bonifacio, Daniela, Dudine, S, Schiavon, I, Romano, A, Martellani, F, Sarcinella, D, Ober, E, DE PELLEGRIN, A, and DI BONITO, Luigi

Subjects
FISH, Her-2, Carcinoma mammario, immunoistochimica
Published
2007

23. Contributo integrato della FNA e della microbiopsia mammaria nella gestione delle donne con anomalie rilevate in corso di screening mammografico: l'esperienza nel 2006 a Trieste

Author

ZANCONATI, FABRIZIO, BONIFACIO, DANIELA, DI BONITO, LUIGI, DI NAPOLI M, DUDINE S, FREZZA F, GASPARINI C, ISIDORO E, MARTELLANI F, ROMANO A, SARCINELLA D, SCHIAVON I, ULCIGRAI L, TONUTTI M, Zanconati, Fabrizio, Bonifacio, Daniela, DI NAPOLI, M, Dudine, S, Frezza, F, Gasparini, C, Isidoro, E, Martellani, F, Romano, A, Sarcinella, D, Schiavon, I, Ulcigrai, L, Tonutti, M, and DI BONITO, Luigi

Subjects
Fine-needle aspiration, lesioni mammarie, screening mammografico
Published
2007

24. Cytological approach to an uncommon pulmonary neoplasm

Author

Dudine, S, Bonifacio, Daniela, Romano, A, Zanconati, Fabrizio, DI BONITO, Luigi, Dudine, S, Bonifacio, Daniela, Romano, A, Zanconati, Fabrizio, and DI BONITO, Luigi

Subjects
cytological diagnosis, Lung cancer
Published
2006

25. Cytological and mammographic correlation: Trieste's experience

Author

Zanconati, Fabrizio, Bonifacio, Daniela, Dudine, S, Martellani, F, Romano, A, Tonutti, M, DI BONITO, Luigi, Zanconati, Fabrizio, Bonifacio, Daniela, Dudine, S, Martellani, F, Romano, A, Tonutti, M, and DI BONITO, Luigi

Subjects
Mammography, cytology, breast lesions
Published
2006

26. Fine needle aspiration of non-palpable breast lesions: Trieste experience

Author

ZANCONATI, FABRIZIO, BONIFACIO, DANIELA, DI BONITO, LUIGI, DUDINE S, GERARDI E, MARTELLANI F, ROMANO A, Zanconati, Fabrizio, Bonifacio, Daniela, Dudine, S, Gerardi, E, Martellani, F, Romano, A, and DI BONITO, Luigi

Subjects
Fine-needle aspiration, cytology, breast lesions
Published
2005

27. Il confronto cito-istologico

Author

DI BONITO, Luigi, Dudine, S, Bonifacio, Daniela, Romano, A, Zanconati, Fabrizio, Gerardi, E., DI BONITO, Luigi, Dudine, S, Bonifacio, Daniela, Romano, A, Zanconati, Fabrizio, and Gerardi, E.

Subjects
correlazione, Diagnosi citologica, diagnosi istologica
Published
2005

28. La citologia agoaspirativa mammaria

Author

ZANCONATI, FABRIZIO, BONIFACIO, DANIELA, DI BONITO, LUIGI, Martellani F., Romano A., Gerardi E., Dudine S., Spinelli R., Centro Didattico Morgani Firenze, Zanconati, Fabrizio, Bonifacio, Daniela, Martellani, F., Romano, A., Gerardi, E., Dudine, S., Spinelli, R., and DI BONITO, Luigi

Subjects
citologia agoaspirativa, categorie diagnostiche, lesioni mammarie
Published
2005

29. Cervical screening: quality control

Author

DI BONITO, LUIGI, BONIFACIO, DANIELA, ZANCONATI, FABRIZIO, DUDINE S, ISIDORO E, ROMANO A, DI BONITO, Luigi, Bonifacio, Daniela, Dudine, S, Isidoro, E, Romano, A, and Zanconati, Fabrizio

Subjects
Pap test, screening, quality control
Published
2005

30. Citologia dei versamenti pleurici

Author

DI BONITO, Luigi, Dudine, S., Bonifacio, Daniela, Romano, A., Zanconati, Fabrizio, SIAPEC-IAP, DI BONITO, Luigi, Dudine, S., Bonifacio, Daniela, Romano, A., and Zanconati, Fabrizio

Subjects
Versametno pleurico, diagnostica citologica
Published
2005

32. La citologia agoaspirativa nella definizione delle lesioni multiple della mammella

Author

ZANCONATI, FABRIZIO, BONIFACIO, DANIELA, COLAUTTI, ISABELLA, DI BONITO, LUIGI, MARTELLANI F, ROMANO A, SPINELLI M, DUDINE S, Zanconati, Fabrizio, Bonifacio, Daniela, Martellani, F, Romano, A, Spinelli, M, Colautti, Isabella, Dudine, S, and DI BONITO, Luigi

Subjects
Citologia agoaspirativa, lesioni mammarie, noduli multipli
Published
2004

33. Il patologo in citologia agoaspirativa mammaria: solo diagnosi?

Author

DI BONITO, Luigi, Zanconati, Fabrizio, Bonifacio, Daniela, Colautti, Isabella, Dudine, S., Martellani, F., Ruggiero, F., Brizzi, F., Cressa, C., Ferrara, P., Lombardo, M., Tonutti, M., Comitato Scientifico, DI BONITO, Luigi, Zanconati, Fabrizio, Bonifacio, Daniela, Colautti, Isabella, Dudine, S., Martellani, F., Ruggiero, F., Brizzi, F., Cressa, C., Ferrara, P., Lombardo, M., and Tonutti, M.

Subjects
citologia agoaspirativa, compresenza patologo e radiologo, lesioni mammarie
Abstract

///

Published
2001

37. Effusion Cytology of Hepatocellular Carcinoma

Author

Falconieri, G., Zanconati, F., Colautti, I., Dudine, S., Davide Gori, Di Bonito, L., Falconieri, Giovanni, Zanconati, Fabrizio, Colautti, I., Dudine, S., Bonifacio, Daniela, and DI BONITO, Luigi

Subjects
immunocytochemistry, liver cirrhosi, hepatocellular carcinoma, liver cirrhosis, effusions
Abstract

This study wants to evaluate effusion cytology on routine smears in pateints with hepatocellular carcinoma. Filed smears from 106 patients with autpsy-proven hepatocellular carcinoma were retrospectively reviewed for the presence of malignant cells. The results indicate that although the yield of hepatocellular carcinoma in effusion cytology iws limited, it may be important in the initial assessment of the disease, given the ineligibility of most patients for invasive procedures and the equivocal features of instrumental investigations. Immunocytochemistry may further assist in differentiating doubtful cases.

Published
1995

42. Cervical cytopathology - an evaluation of its accuracy based on cytohistologic comparison

Author

Dibonito, L., Falconieri, G., Tomasic, G., Colautti, I., Bonifacio, D., and Dudine, S.

Subjects
Cervical cancer -- Diagnosis, Cervix dysplasia -- Diagnosis, Cytodiagnosis -- Evaluation, Business, Health care industry
Abstract

According to the authors' abstract of an article published in Cancer, 'Background: Although Papanicolaou cytology represents the most effective technique to prevent and detect precancerous conditions of the uterine cervix, [...]

Published
1993

43. Cervical cytopathology: An evaluation of its accuracy based on cytohistologic comparison

Author

Gorana Tomasic, Daniela Bonifacio, Luigi Dibonito, I. Colautti, Sandra Dudine, Giovanni Falconieri, DI BONITO, Luigi, Falconieri, G, Tomasic, G, Colautti, I, Bonifacio, Daniela, and Dudine, S.

Subjects
Adult, Cancer Research, medicine.medical_specialty, Adolescent, Uterine Cervical Neoplasms, Papanicolaou stain, Cervix Uteri, Cervical intraepithelial neoplasia, Sensitivity and Specificity, Predictive Value of Tests, Cytology, Humans, Medicine, False Negative Reactions, Aged, Aged, 80 and over, Vaginal Smears, Gynecology, business.industry, Carcinoma in situ, Papanicolaou Test, Middle Aged, Uterine Cervical Dysplasia, medicine.disease, Oncology, Cytopathology, Predictive value of tests, Female, Radiology, business, Precancerous Conditions, Carcinoma in Situ
Abstract

Background. Although Papanicolaou cytology represents the most effective technique to prevent and detect precancerous conditions of the uterine cervix, its false-negative yield is still a reason of concern among pathologists and gynecologists. Methods. Because histologic control is one of the best ways to assess the accuracy of cytology diagnosis, the authors have investigated 1000 women who had cervical smears and tissue sampling obtained during the same colposcopic evaluation between 1987 and 1990. Results. Out of 1000 cases (average age, 34.6 years; range, 14–80 years), 918 had adequate, 62 had less than optimal, and 10 had unsatisfactory samples. Cytology unsatisfactory and less than optimal cases as well as inadequate histology cases have been disregarded from all calculations. After histologic comparison, confirmed negatives were 622 of 918 (67.8%). Cytologic diagnoses of cervical intra-epithelial neoplasia (CIN) I were 96, of CIN II were 44, of CIN III, inclusive of carcinoma in situ, were 39, and of invasive carcinoma were 2. Atypical cases were 56. The overall sensitivity was 76.3%, with group sensitivity rates increasing directly with CIN grade. Positive predictive value was 80.2%. Specificity was 93.0%, and negative predictive value was 91.3%. False-negatives were 59 of 681 (8.7%), basically due to sampling errors. Among true-positives, there was 1 category discrepancy in 30 cases (mostly undercalled or overcalled CIN II) and 2 category discrepancies in 4 cases. Conclusions. Cervical cytology has an overall accuracy close to that reported in studies employing indirect control methods, such as patient follow-up. Higher sensitivity rates emerged for CIN II, CIN III, and cervical carcinoma. Our figures of sensitivity and specificity may represent a useful reference source for future studies dealing with quality control in cervical cytopathology.

Published
1993
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44. Cytopathology of malignant mesothelioma: a study of its patterns and histological bases

Author

D Bonifacio Gori, Luigi Dibonito, I. Colautti, Sandra Dudine, Giovanni Falconieri, Luigi Giarelli, DI BONITO, Luigi, Falconieri, G, Colautti, I, Bonifacio, Daniela, Dudine, S, and Giarelli, L.

Subjects
Male, Mesothelioma, Pathology, medicine.medical_specialty, Histology, Cytodiagnosis, Pleural Neoplasms, Autopsy, Malignancy, Pathology and Forensic Medicine, Carcinoembryonic antigen, Cytology, medicine, Humans, Peritoneal Neoplasms, Aged, Retrospective Studies, Aged, 80 and over, biology, business.industry, General Medicine, Middle Aged, medicine.disease, Cytopathology, biology.protein, Adenocarcinoma, Female, business
Abstract

We have reviewed the effusion cytology of 51 cases of histologically proven malignant mesothelioma of the pleura (49 cases) and the peritoneum (2 cases). The patient group included 45 males and 6 females, aged 45-83 yr. A cytological diagnosis of malignancy had been rendered on 43 cases, and in 30 of them it was consistent with, or at least suggestive of, a mesothelioma. Diagnostic clues, especially evident in epithelial and biphasic tumors were hypercellularity and/or morular aggregates of malignant cells showing scalloped borders and nuclei with dense chromatin and evident nucleoli. Cytomegaly with multinucleation was also frequently observed. Reactive mesothelial cells were often present along with other non specific features such as red blood cells, fibrin, necrotic debris. In 13 cases, a diagnosis of malignancy was entertained but mesothelioma, although considered, was not reported out because of scantiness of material. In four cases, adenocarcinoma was erroneously diagnosed for the presence of deceptive cell vacuoles. In eight cases, no diagnostic cells were recovered in repeated effusions. The first diagnosis was a cytologic one in 37 patients, Tissue study was performed on autopsy (35 patients) and surgical material. The latter was the only source of histology in six cases. Immunocytochemical investigation was negative for carcinoembryonic antigen in all but one tested cases (1/21) and positive for human milk fat globulin in about one-half of the epithelial and biphasic tumors. In 18 of 21 cases, positivity for combined high- and low-molecular-weight keratins was detected.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1993

45. Cytology of transitional-cell carcinoma of the urinary bladder: diagnostic yield and histologic basis

Author

Sandra Dudine, Giovanni Falconieri, Mohamed Moallim Musse, Luigi Dibonito, DI BONITO, Luigi, Musse, Mm, Dudine, S, and Falconieri, G.

Subjects
medicine.medical_specialty, Pathology, Histology, cytological diagnosis, Urology, malignant neoplasm, Pathology and Forensic Medicine, transitional-cell carcinoma, Cytology, Atypia, Carcinoma, Humans, Medicine, Exfoliative cytology, Carcinoma, Transitional Cell, Urinary bladder, business.industry, Atypical cells, General Medicine, medicine.disease, medicine.anatomical_structure, Transitional cell carcinoma, Urinary Bladder Neoplasms, Pleomorphism (cytology), business
Abstract

The diagnostic yield of cytology in histologically proven transitional-cell carcinoma (TCC) of the urinary bladder has been studied in 100 cases. Cytohistologic correlation rates were 20 percent, 61.7 percent, and 92.8 percent, respectively, for grade 1, 2, and 3 tumors. When further evaluated, G2 cases were segregated into 2 subcategories, G2a and G2b, based on histologic preservation of nuclear polarity, pleomorphism, and other cellular irregularities. Correlation rates were rather low for G2a cases (6/18, 33%) and high for G2b cases, (23/29; 79%). The prevalence of atypical cells was 2 (11.1%) cases in G2a and 16 (55.2%) cases in G2b. The results of this study confirm that cytology has an extremely varying diagnostic yield in urinary bladder TCC. Greater cell exfoliation, increased atypia, and a tendency to infiltration of G2b and G3 cases probably account for the higher diagnostic yield detected in these groups. © 1992 Wiley-Liss, Inc.

Published
1992

46. Cytopathology of exocrine pancreatic carcinoma in effusions

Author

L, Di Bonito, S, Dudine, G, Falconieri, DI BONITO, Luigi, Dudine, S, and Falconieri, G.

Subjects
Cell Nucleus, Male, Staining and Labeling, malignant effusion, Pancreatic Neoplasms, Pleural Effusion, Connective Tissue, cytology, Ascitic Fluid, Humans, Female, Autopsy, Pancreatic carcinoma, Aged
Abstract

The cytomorphologic features were analyzed in 26 fluid samples (18 peritoneal and 8 pleural fluids) obtained in vivo from 20 patients with pancreatic carcinoma. All tumors were ductal adenocarcinomas, as proven histologically on autopsy samples. The basic cytomorphologic pattern in the smears was that of a malignant glandular tumor, consisting of cell groups with various degrees of cohesiveness. The most prominent feature was a linear arrangement (the so-called "Indian file") of tumor cells showing nuclear molding; these aggregates were frequently closely associated with the flat round clusters of cells. Other nonspecific features of adenocarcinoma included eccentric hyperchromatic nuclei, abundant, often well-preserved vacuolated cytoplasm, a variable amount of fibrin and a reactive background. Review of the autopsy specimens also revealed the presence of an "Indian-file" pattern in most cases, especially when a conspicuous desmoplastic reaction was present. These findings suggest that pancreatic carcinoma should be included in the differential diagnosis of positive serous effusions showing these cytomorphologic features.

Published
1991

47. Correction: Clinical validation of full HR-HPV genotyping HPV Selfy assay according to the international guidelines for HPV test requirements for cervical cancer screening on clinician-collected and self-collected samples.

Author

Avian A, Clemente N, Mauro E, Isidoro E, Di Napoli M, Dudine S, Del Fabro A, Morini S, Perin T, Giudici F, Cammisuli T, Foschi N, Mocenigo M, Montrone M, Modena C, Polenghi M, Puzzi L, Tomaic V, Valenti G, Sola R, Zanolla S, Vogrig E, Riva E, Angeletti S, Ciccozzi M, Castriciano S, Pachetti M, Petti M, Centonze S, Gerin D, Banks L, Marini B, Canzonieri V, Sopracordevole F, Zanconati F, and Ippodrino R

Published
2023
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48. Clinical validation of full HR-HPV genotyping HPV Selfy assay according to the international guidelines for HPV test requirements for cervical cancer screening on clinician-collected and self-collected samples.

Author

Avian A, Clemente N, Mauro E, Isidoro E, Di Napoli M, Dudine S, Del Fabro A, Morini S, Perin T, Giudici F, Cammisuli T, Foschi N, Mocenigo M, Montrone M, Modena C, Polenghi M, Puzzi L, Tomaic V, Valenti G, Sola R, Zanolla S, Vogrig E, Riva E, Angeletti S, Ciccozzi M, Castriciano S, Pachetti M, Petti M, Centonze S, Gerin D, Banks L, Marini B, Canzonieri V, Sopracordevole F, Zanconati F, and Ippodrino R

Subjects
Early Detection of Cancer methods, Female, Genotype, Humans, Mass Screening, Papillomaviridae genetics, Reproducibility of Results, Sensitivity and Specificity, Papillomavirus Infections complications, Papillomavirus Infections diagnosis, Uterine Cervical Neoplasms diagnosis
Abstract

Background: According to international guidelines, Human Papillomavirus (HPV) DNA tests represent a valid alternative to Pap Test for primary cervical cancer screening, provided that they guarantee balanced clinical sensitivity and specificity for cervical intraepithelial neoplasia grade 2 or more (CIN2+) lesions. The study aimed to assess whether HPV Selfy (Ulisse BioMed - Trieste, Italy), a full-genotyping HPV DNA test that detects and differentiates 14 high-risk HPV (HR-HPV) types, meets the criteria for primary cervical cancer screening described in the international guidelines, on clinician-collected as well as on self-collected samples., Methods: For each participant woman, consecutively referring to Azienda Sanitaria Universitaria Giuliano Isontina (Trieste, Italy) and CRO-National Cancer Institute (Aviano, Italy) for the cervical cancer screening program, the following samples were tested: (a) a clinician-collected cervical specimen, analyzed with the reference test (Hybrid Capture®2 test, HC2) and HPV Selfy; and (b) a self-collected vaginal sample, analyzed with HPV Selfy. Enrolled women were also asked to fulfill a questionnaire about self-sampling acceptability. As required by guidelines, a non-inferiority test was conducted to compare the clinical performance of the test under evaluation with its reference test., Results: HPV Selfy clinical sensitivity and specificity resulted non-inferior to those of HC2. By analysis of a total of 889 cervical liquid-based cytology samples from a screening population, of which 98 were from women with CIN2+, HPV Selfy showed relative sensitivity and specificity for CIN2+ of 0.98 and 1.00 respectively (non-inferiority score test: P = 0.01747 and P = 0.00414, respectively); the test reached adequate intra- and inter-laboratory reproducibility. Moreover, we demonstrated that the performance of HPV Selfy on self-collected vaginal samples was non-inferior to the performance obtained on clinician-collected cervical specimen (0.92 relative sensitivity and 0.97 relative specificity). Finally, through HPV Selfy genotyping, we were able to describe HPV types prevalence in the study population., Conclusions: HPV Selfy fulfills all the requirements of the international Meijer's guidelines and has been clinically validated for primary cervical cancer screening purposes. Moreover, HPV Selfy has also been validated for self-sampling according to VALHUDES guidelines. Therefore, at date, HPV Selfy is the only full-genotyping test validated both for screening purposes and for self-sampling. Trial registration ASUGI Trieste n. 16008/2018; CRO Aviano n.17149/2018., (© 2022. The Author(s).)

Published
2022
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49. [The cyto-histologic comparison].

Author

Di Bonito L, Dudine S, Bonifacio D, Romano A, Zanconati F, Martellani F, and Gerardi E

Subjects
Humans, Reproducibility of Results, Pathology standards
Published
2005

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