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183 results on '"Dudek, Nadine L."'

1. The self-peptide repertoire plays a critical role in transplant tolerance induction

Author

Son, Eric T., Faridi, Pouya, Paul-Heng, Moumita, Leong, Mario L., English, Kieran, Ramarathinam, Sri H., Braun, Asolina, Dudek, Nadine L., Alexander, Ian E., Lisowski, Leszek, Bertolino, Patrick, Bowen, David G., Purcell, Anthony W., Mifsud, Nicole A., and Sharland, Alexandra F.

Subjects
Major histocompatibility complex -- Physiological aspects -- Health aspects, Immunological tolerance -- Physiological aspects, Peptides -- Physiological aspects -- Health aspects, Health care industry
Abstract

While direct allorecognition underpins both solid organ allograft rejection and tolerance induction, the specific molecular targets of most directly alloreactive [CD8.sup.+] T cells have not been defined. In this study, we used a combination of genetically engineered major histocompatibility complex class I (MHC I) constructs, mice with a hepatocyte-specific mutation in the class I antigen-presentation pathway, and immunopeptidomic analysis to provide definitive evidence for the contribution of the peptide cargo of allogeneic MHC I molecules to transplant tolerance induction. We established a systematic approach for the discovery of directly recognized pMHC epitopes and identified 17 strongly immunogenic H-2[K.sup.b]-associated peptides recognized by [CD8.sup.+] T cells from B10.BR (H-[2.sup.k]) mice, 13 of which were also recognized by BALB/c (H-[2.sup.d]) mice. As few as 5 different tetramers used together were able to identify a high proportion of alloreactive T cells within a polyclonal population, suggesting that there are immunodominant allogeneic MHC-peptide complexes that can account for a large component of the alloresponse., Introduction Allorecognition may result in either graft rejection, graft versus host disease, or transplantation tolerance, depending on the context in which the recipient immune system encounters the allogeneic major histocompatibility [...]

Published
2021
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4. T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

Author

Beringer, Dennis X, Kleijwegt, Fleur S, Wiede, Florian, van der Slik, Arno R, Loh, Khai Lee, Petersen, Jan, Dudek, Nadine L, Duinkerken, Gaby, Laban, Sandra, Joosten, Antoinette, Vivian, Julian P, Chen, Zhenjun, Uldrich, Adam P, Godfrey, Dale I, McCluskey, James, Price, David A, Radford, Kristen J, Purcell, Anthony W, Nikolic, Tatjana, Reid, Hugh H, Tiganis, Tony, Roep, Bart O, and Rossjohn, Jamie

Published
2015
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10. Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 Diabetes

Author

Pathiraja, Vimukthi, Kuehlich, Janine P., Campbell, Peter D., Krishnamurthy, Balasubramanian, Loudovaris, Thomas, Coates, P. Toby H., Brodnicki, Thomas C., O’Connell, Philip J., Kedzierska, Katherine, Rodda, Christine, Bergman, Philip, Hill, Erin, Purcell, Anthony W., Dudek, Nadine L., Thomas, Helen E., Kay, Thomas W.H., and Mannering, Stuart I.

Published
2015
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13. Short Duration Alagebrium Chloride Therapy Prediabetes Does Not Inhibit Progression to Autoimmune Diabetes in an Experimental Model

Author

Borg, Danielle J., primary, Faridi, Pouya, additional, Giam, Kai Lin, additional, Reeves, Peta, additional, Fotheringham, Amelia K., additional, McCarthy, Domenica A., additional, Leung, Sherman, additional, Ward, Micheal S., additional, Harcourt, Brooke E., additional, Ayala, Rochelle, additional, Scheijen, Jean L., additional, Briskey, David, additional, Dudek, Nadine L., additional, Schalkwijk, Casper G., additional, Steptoe, Raymond, additional, Purcell, Anthony W., additional, and Forbes, Josephine M., additional

Published
2021
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15. MR1 presents microbial vitamin B metabolites to MAIT cells

Author

Kjer-Nielsen, Lars, Patel, Onisha, Corbett, Alexandra J., Le Nours, Jerome, Meehan, Bronwyn, Liu, Ligong, Bhati, Mugdha, Chen, Zhenjun, Kostenko, Lyudmila, Reantragoon, Rangsima, Williamson, Nicholas A., Purcell, Anthony W., Dudek, Nadine L., McConville, Malcolm J., O'Hair, Richard A.J., Khairallah, George N., Godfrey, Dale I., Fairlie, David P., Rossjohn, Jamie, and McCluskey, James

Subjects
Virulence (Microbiology) -- Research -- Physiological aspects -- Health aspects, T cells -- Physiological aspects -- Health aspects -- Research, Metabolites -- Physiological aspects -- Health aspects -- Research, Vitamin B -- Physiological aspects -- Health aspects -- Research, Vitamin B complex -- Physiological aspects -- Health aspects -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Antigen-presenting molecules, encoded by the major histocompatibility complex (MHC) and CD1 family, bind peptideand lipid-based antigens, respectively, for recognition by T cells. Mucosal- associated invariant T (mAit) cells are an abundant population of innate-like T cells in humans that are activated by an antigen(s) bound to the MHC class I-like molecule MR1. Although the identity of MR1-restricted antigen(s) is unknown, it is present in numerous bacteria and yeast. Here we show that the structure and chemistry within the antigen-binding cleft of MR1 is distinct from the MHC and CD1 families. MR1 is ideally suited to bind ligands originating from vitamin metabolites. The structure of MR1 in complex with 6-formyl pterin, a folic acid (vitamin B9) metabolite, shows the pterin ring sequestered within MR1. Furthermore, we characterize related MR1-restricted vitamin derivatives, originating from the bacterial riboflavin (vitamin B2) biosynthetic pathway, which specifically and potently activate MAIT cells. Accordingly, we show that metabolites of vitamin B represent a class of antigen that are presented by MR1 for MAIT-cell immunosurveillance. As many vitamin biosynthetic pathways are unique to bacteria and yeast, our data suggest that MAIT cells use these metabolites to detect microbial infection., MAIT cells, which comprise up to 10% of the peripheral blood T-cell population of humans, are readily detected in blood, mesenteric lymph nodes and the gastrointestinal mucosa (1). Despite the [...]

Published
2012
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16. Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

Author

Ooi, Joshua D., Petersen, Jan, Tan, Yu H., Huynh, Megan, Willett, Zoe J., Ramarathinam, Sri H., Eggenhuizen, Peter J., Loh, Khai L., Watson, Katherine A., Gan, Poh Y., Alikhan, Maliha A., Dudek, Nadine L., Handel, Andreas, Hudson, Billy G., Fugger, Lars, Power, David A., Holt, Stephen G., Coates, P. Toby, Gregersen, Jon W., Purcell, Anthony W., Holdsworth, Stephen R., La Gruta, Nicole L., Reid, Hugh H., Rossjohn, Jamie, and Kitching, A. Richard

Subjects
Immune response -- Observations, T cells -- Health aspects, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Author(s): Joshua D. Ooi [1]; Jan Petersen [2, 3]; Yu H. Tan [2]; Megan Huynh [1]; Zoe J. Willett [1]; Sri H. Ramarathinam [2]; Peter J. Eggenhuizen [1]; Khai L. [...]

Published
2017
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17. HLA class ii specificity assessed by high-density peptide microarray interactions

Author

Osterbye, Thomas, Nielsen, Morten, Dudek, Nadine L., Ramarathinam, Sri H., Purcell, Anthony W., Schafer-Nielsen, Claus, Buus, Soren, Osterbye, Thomas, Nielsen, Morten, Dudek, Nadine L., Ramarathinam, Sri H., Purcell, Anthony W., Schafer-Nielsen, Claus, and Buus, Soren

Abstract

The ability to predict and/or identify MHC binding peptides is an essential component of T cell epitope discovery, something that ultimately should benefit the development of vaccines and immunotherapies. In particular, MHC class I prediction tools have matured to a point where accurate selection of optimal peptide epitopes is possible for virtually all MHC class I allotypes; in comparison, current MHC class II (MHC-II) predictors are less mature. Because MHC-II restricted CD4+ T cells control and orchestrated most immune responses, this shortcoming severely hampers the development of effective immunotherapies. The ability to generate large panels of peptides and subsequently large bodies of peptide-MHC-II interaction data are key to the solution of this problem, a solution that also will support the improvement of bioinformatics predictors, which critically relies on the availability of large amounts of accurate, diverse, and representative data. In this study, we have used rHLA-DRB1∗01:01 and HLA-DRB1∗03:01 molecules to interrogate high-density peptide arrays, in casu containing 70,000 random peptides in triplicates. We demonstrate that the binding data acquired contains systematic and interpretable information reflecting the specificity of the HLA-DR molecules investigated, suitable of training predictors able to predict T cell epitopes and peptides eluted from human EBV-transformed B cells. Collectively, with a cost per peptide reduced to a few cents, combined with the flexibility of rHLA technology, this poses an attractive strategy to generate vast bodies of MHC-II binding data at an unprecedented speed and for the benefit of generating peptide-MHC-II binding data as well as improving MHC-II prediction tools.

Published
2020

19. Contributors

Author

Aalen, Reidunn B., primary, Abdel-Wahab, Yasser H.A., additional, Adams, Michael E., additional, Adan, Roger A.H., additional, Ahima, Rexford S., additional, Ahmed, Naima, additional, Al-Massadi, Omar, additional, Altstein, Miriam, additional, Anouar, Youssef, additional, Anselmi, Laura, additional, Ansorge, Siegfried, additional, Antcheva, Nikolinka, additional, Antonova-Koch, Yevgeniya, additional, Appel, Jon R., additional, Arik, Anam J., additional, Arter, Alison L., additional, Arvan, Peter, additional, Ashkenazi, Avraham, additional, Baas, P.W., additional, Bado, André, additional, Baird, Andrew, additional, Baiula, Monica, additional, Bakaletz, Lauren O., additional, Bakken, Earl E., additional, Balaskó, Márta, additional, Baldwin, Graham S., additional, Banks, William A., additional, Barra, Donatella, additional, Barson, Jessica R., additional, Basille, Magali, additional, Bauer, Natalie N., additional, Bedini, Andrea, additional, Beeton, Christine, additional, Begley, David J., additional, Beinfeld, Margery C., additional, Bendena, William G., additional, Benoit, Stephen C., additional, Bentov, Itay, additional, Bern, Howard, additional, Bierbaum, Gabriele, additional, Billington, Charles J., additional, Blasiak, Anna, additional, Block, Norman L., additional, Bloom, Stephen. R., additional, Bonney, Iwona, additional, Bowie, John H., additional, Boyd, Sunny K., additional, Brain, Susan D., additional, Brede, Dag A., additional, Broeck, Jozef Vanden, additional, Brown, Kelly L., additional, Brown, Mark R., additional, Bugni, James M., additional, Bundgaard, Jens R., additional, Burel, Delphine, additional, Butenko, Melinka A., additional, Call, Melissa J., additional, Calò, Girolamo, additional, Campbell, Duncan John, additional, Carlsson, Anna, additional, Carr, Daniel B., additional, Carraway, Robert E., additional, Carreira, Marcos C., additional, Casanueva, Felipe F., additional, Cassella, Sarah N., additional, Casson, Stuart A., additional, Castaño, Justo P., additional, Cebrat, Marek, additional, Chappe, Valerie, additional, Chatenet, David, additional, Chen, Keqiang, additional, Chen, Chen, additional, Chen, Longchuan, additional, Chen, Duan, additional, Cheng, Carrie Y.Y., additional, Cho, Sung Ki, additional, Chow, Billy K.C., additional, Christopoulos, Arthur, additional, Chu, Shijian, additional, Clarke, Iain J., additional, Coast, Geoffrey M., additional, Compere, Vincent, additional, Concepcion, Gisela P., additional, Cone, Roger D., additional, Conlon, J. Michael, additional, Cornélissen, Germaine, additional, Courel, Maité, additional, Couture, Réjean, additional, Cramer, W.A., additional, Croft, Nathan P., additional, Crujeiras, Ana B., additional, Cuttitta, Frank, additional, Cynis, Holger, additional, D’Acquisto, F., additional, Davis, Jon F., additional, Davis, Thomas P., additional, de La Serre, Claire Barbier, additional, de Lartigue, Guillaume, additional, de Lecea, Luis, additional, de Oliveira Santos, Marcelo, additional, De Waard, Michel, additional, Bolette Hartmann, Carolyn F. Deacon, additional, Delestre, Charlène, additional, Delgado, Mario, additional, Demuth, Hans-Ulrich, additional, Deng, Xiaoming, additional, Dharmawardhana, Palitha, additional, Di Cosmo, Anna, additional, Dias, Simoni Campos, additional, Dickerson, Jonathan W., additional, Diep, Dzung B., additional, Dircksen, H., additional, Dischinger, Jasmin, additional, do Rego, Jean-Claude, additional, Dobner, Paul R., additional, Dockray, Graham J., additional, Dores, Robert M., additional, Ducroc, Robert, additional, Dudek, Nadine L., additional, Dumont, Yvan, additional, Duraffourd, Celine, additional, Duterte-Boucher, Dominique, additional, Eberlé, Alex N., additional, Egleton, Richard D., additional, Eipper, Betty A., additional, Engel, Jorg B., additional, Englander, Ella W., additional, Epelbaum, Jacques, additional, Erlanson-Albertsson, Charlotte, additional, Evangelista, S., additional, Fagan, Karen A., additional, Farber, Joshua M., additional, Farkasfalvi, Klára, additional, Fekete, Csaba, additional, Flatt, Peter R., additional, Flower, R.J., additional, Forssmann, Wolf-Georg, additional, Fournier, Alain, additional, Foy, Kevin Chu, additional, Franco, Octávio Luiz, additional, Frenkel, Dan, additional, Fricker, Lloyd D., additional, de la Fuente-Núñez, César, additional, Fukuda, Hiroo, additional, Gäde, Gerd, additional, Galas, Ludovic, additional, Gallagher, Patricia E., additional, Gandolfo, Pierrick, additional, Garcia-Espinosa, Maria A., additional, García-Sanmartín, Josune, additional, Geary, Nori, additional, Geng, Hua, additional, Germano, Patrizia M., additional, Goetze, Jens P., additional, Gonzalez, Alexis A., additional, Gonzalez, Ana, additional, Gosnell, Blake A., additional, Goto, Katsutoshi, additional, Gourcerol, Guillaume, additional, Gozes, I., additional, Gracia-Navarro, Francisco, additional, Grayson, Bernadette E., additional, Greeley, George H., additional, Greenwald-Yarnell, Megan, additional, Gressens, Pierre, additional, Grider, John R., additional, Grünewald, Jan, additional, Guerreiro, Juliano R., additional, Guerrini, Remo, additional, Guida, Filomena, additional, Guilhaudis, Laure, additional, Guilmeau, Sandra, additional, Gundlach, Andrew L., additional, Gutkowska, Jolanta, additional, Hackbarth, Clifton, additional, Haim Ohana, Y., additional, Halberg, Franz, additional, Hallberg, Mathias, additional, Hamidi, Sayyed A., additional, Han, Song, additional, Han, Ji-Sheng, additional, Hancock, Robert E.W., additional, Haque, Samer-ul, additional, Hara-Nishimura, Ikuko, additional, Hariton, Aliza, additional, Hartsock, Wendy J., additional, Harvey, Alan L., additional, Hasunuma, Itaru, additional, Henning, Robert J., additional, Heppner, Kristy M., additional, Hertweck, Kate L., additional, Herzog, Herbert, additional, Higashiyama, Tetsuya, additional, Hinuma, Shuji, additional, Hippenstiel, Stefan, additional, Hirakawa, Yuki, additional, Hirose, Shuichi, additional, Hirsch, Jochen R., additional, Hocke, Andreas C., additional, Hodges, Robert S., additional, Hoffmann, Werner, additional, Hökfelt, Tomas, additional, Holst, Jens Juul, additional, Holzer, Peter, additional, Horodyski, Frank M., additional, Hosoda, Hiroshi, additional, Hou, Xiaowen, additional, Huffaker, Alisa, additional, Iijima, Norio, additional, Ikeuchi, Momoko, additional, Imperial, Julita S., additional, Improta, Giovanna, additional, Inui, Akio, additional, Irwin, Nigel, additional, Ishii, Munehiro, additional, Iturrioz, Xavier, additional, Ivanisevic, Ljubica, additional, Iwao, Hiroshi, additional, Iwata, Takeo, additional, Izumi, Yasukatsu, additional, Izumiyama, Hajime, additional, Jankowski, Marek, additional, Janssen, Tom, additional, Jégou, Sylvie, additional, Jensen, Robert T., additional, Jethwa, Preeti H., additional, Johannessen, Helene, additional, Johanson, Conrad, additional, Judkowski, Valeria, additional, Kaczmarek, Przemyslaw, additional, Kageyama, Haruaki, additional, Kakimoto, Tatsuo, additional, Kang, Ki Sung, additional, Kangawa, Kenji, additional, Kastin, Abba J., additional, Kato, Johji, additional, Kaumaya, Pravin T.P., additional, Keep, Richard F., additional, Kem, William R., additional, Khomenko, Tetyana, additional, Kikuyama, Sakae, additional, Kim, Young-Joon, additional, Kimura, Sadao, additional, King, Ross, additional, Kiptoo, Paul, additional, Kishimoto, Ichiro, additional, Kitamura, Kazuo, additional, Kluczyk, Alicja, additional, Kobori, Hiroyuki, additional, Kodama, Yosuke, additional, Kojima, Masayasu, additional, Kondo, Yuki, additional, Körner, Meike, additional, Kosson, Piotr, additional, Kotz, Catherine M., additional, Krishnan, Bhavani, additional, Kulseng, Bård, additional, Kumpf, Robert, additional, Laburthe, Marc, additional, Lacaille, Hélène, additional, Ladenheim, Ellen E., additional, Ladram, Ali, additional, Laksitorini, Marlyn D., additional, Lambert, David G., additional, Lange, Angela B., additional, Langhans, Wolfgang, additional, Larauche, Muriel, additional, Larhammar, Dan, additional, Larráyoz, Ignacio M., additional, Lattanzi, Roberta, additional, Lechan, Ronald M., additional, Lefranc, Benjamin, additional, Leibowitz, Sarah F., additional, Lelièvre, Vincent, additional, Leprince, Jérôme, additional, Levine, Allen S., additional, Li, Qun, additional, Lifshitz, Veronica, additional, Lihrmann, Isabelle, additional, Chi-Jen Lin, James, additional, Lindberg, Iris, additional, Lindsey, Keith, additional, Lipkowski, Andrzej W., additional, Liron, T., additional, Liu, Junli, additional, Liu, Ying, additional, Liu, Min, additional, Llorens-Cortes, Catherine, additional, Loizidou, Marilena, additional, Lopez, C., additional, Lovejoy, David A., additional, Luca, Vincenzo, additional, Lutz, Thomas A., additional, Ma, Sherie, additional, Mains, Richard E., additional, Malagon, Maria M., additional, Malendowicz, Ludwik K., additional, Wan, Jennifer Man-Fan, additional, Mangoni, Maria Luisa, additional, Manigrasso, Michaele B, additional, Marahiel, Mohamed A., additional, Marco, Heather G., additional, Maric-Bilkan, Christine, additional, Marks, Nikki J., additional, Martin, Roland, additional, Martinez, Vicente, additional, Martínez, Alfredo, additional, Martinez-Fuentes, Antonio J., additional, Masler, Edward P., additional, Matsubayashi, Yoshikatsu, additional, Mattu, Harman S., additional, Maule, Aaron G., additional, McLaughlin, Patricia J., additional, McMurtry, Ivan F., additional, Meelkop, Ellen, additional, Mehdi, Saher, additional, Melchiorri, Pietro, additional, Millar, R.P., additional, Miller, Laurence J., additional, Miller, Miles, additional, Million, Mulugeta, additional, Minamino, Naoto, additional, Mittelman, M., additional, Miyauchi, Takashi, additional, Miyazato, Mikiya, additional, Mizoguchi, Hirokazu, additional, Mohme, Malte, additional, Montero-Hadjadje, Maité, additional, Moody, Terry W., additional, Mookherjee, Neeloffer, additional, Moran, Timothy H., additional, Morganstern, Irene, additional, Mori, Masatomo, additional, Morin, Fabrice, additional, Morris, John F., additional, Moura, Daniel S., additional, Mudge, Anna J., additional, Mul, Joram D., additional, Murthy, Karnam S., additional, Myers, Martin G., additional, Nachman, Ronald J., additional, Nahon, Jean-Louis, additional, Naithani, Sushma, additional, Nakada, Tomoaki, additional, Nakamachi, Tomoya, additional, Nakamura, Yuki, additional, Nalivaeva, Natalia N., additional, Nasrallah, June B., additional, Nässel, Dick R., additional, Navar, L. Gabriel, additional, Neelakantan, Pratap, additional, Negri, Lucia, additional, Nes, Ingolf F., additional, Neumann, D., additional, Neveu, Cindy, additional, Ng, Tzi Bun, additional, Ng, Stephanie Y.L., additional, Nicholson, Graham M., additional, Nicolas, Pierre, additional, Nishikimi, Toshio, additional, Nishiyama, Mariko, additional, Nogueiras, Rubén, additional, Norton, Raymond S., additional, Novotny, Laura A., additional, Nowak, Krzysztof W., additional, Nyberg, Fred, additional, Ochoa-Callejero, Laura, additional, Ove Ögren, Sven, additional, Ohgusu, Hideko, additional, Oh-I, Shinsuke, additional, Ojo, Opeolu O., additional, Olivera, Baldomero M., additional, Olucha-Bordonau, Francisco E., additional, Oppenheim, Joost J., additional, Orchard, Ian, additional, Ouellette, André J., additional, Pacheco-López, Gustavo, additional, Page, Nigel M., additional, Palma, Mario Sergio, additional, Pan, Weihong, additional, Park, Yoonseong, additional, Parmentier, Marc, additional, Passemard, Sandrine, additional, Patterson, Michael, additional, Paunovic, Brankica, additional, Pearce, Gregory, additional, Pedersen, Jens, additional, Peeters, Theo L., additional, Eugene Pekary, A., additional, Pelletier, Georges, additional, Perboni, Simona, additional, Pérez-Tilve, Diego, additional, Perjés, Ábel, additional, Perretti, M., additional, Pétervári, Erika, additional, Pinilla, Clemencia, additional, Pinskim, Jacek, additional, Pisegna, Joseph R., additional, Plankensteiner, Kristof, additional, Podvin, Sonia, additional, Poitras, Pierre, additional, Polese, Gianluca, additional, Pollock, David M., additional, Porto, William Farias, additional, Possani, Lourival D., additional, Pothoulakis, Charalabos, additional, Presse, Françoise, additional, Prieto, Minolfa C., additional, Prutchi-Sagiv, S., additional, Purcell, Anthony W., additional, Purtell, Louise, additional, Quirion, Rémi, additional, Rabat, Catalina Abad, additional, Rademaker, Miriam, additional, Rajpal, Gautam, additional, Randeva, Harpal S., additional, Rebuffat, Sylvie, additional, Reeve, Joseph R., additional, Rehfeld, Jens F., additional, Reinhold, Dirk, additional, Reinscheid, Rainer K., additional, Reubi, Jean Claude, additional, Rezvani, Katayoun, additional, Ribeiro, Suzana Meira, additional, Richard, D., additional, Richards, Mark, additional, Riehle, Michael A., additional, Rinaldi, Andrea C., additional, Rode, Bernd M., additional, de la Vega, Ricardo C. Rodríguez, additional, Rotzinger, Susan, additional, Rucinski, Marcin, additional, Ruskoaho, Heikki, additional, Ryan, Philip J., additional, Sabatier, Jean-Marc, additional, Sahl, Hans-Georg, additional, Said, Sami I., additional, Sakurada, Tsukasa, additional, Sakurada, Shinobu, additional, Salomon, David S., additional, Samson, Willis K., additional, Sandor, Zsuzsanna, additional, Saragovi, H. Uri, additional, Sasaki, Kazuki, additional, Sato, Takahiro, additional, Satou, Ryousuke, additional, Sawa, Shinichiro, additional, Sayegh, Ayman I., additional, Schally, Andrew V., additional, Schilling, Stephan, additional, Schoofs, Liliane, additional, Schooley, David A., additional, Schubert, Mitchell L., additional, Segalas-Milazzo, Isabelle, additional, Seidah, Nabil G., additional, Selsted, Michael E., additional, Seroogy, Kim B., additional, Severini, Cinzia, additional, Sexton, Patrick M., additional, Shai, Yechiel, additional, Sharma, O., additional, Shichiri, Masayoshi, additional, Shimada, Tomoo, additional, Shimizu, Hiroyuki, additional, Shioda, Seiji, additional, Shulkes, Arthur, additional, Siahaan, Teruna J., additional, Siemion, Ignacy Z., additional, Silva, Osmar Nascimento, additional, Silva-Filho, Marcio C., additional, Skwarczynski, Mariusz, additional, Small, Caroline. J., additional, Smith, Craig M., additional, Smith, David E., additional, Smith, A. Ian, additional, Solomon, Beka, additional, Solomon, Travis E., additional, Sospedra, Mireia, additional, Souroujon, M.C., additional, Spampinato, Santi, additional, Spindel, Eliot R., additional, Steiger, A., additional, Stengel, Andreas, additional, Sternini, Catia, additional, Steyn, Frederik J., additional, Stopa, Edward, additional, Strowski, Mathias Z., additional, Sugano, Shigeo S., additional, Sundström, Görel, additional, Sutcliffe, J. Gregor, additional, Suttorp, Norbert, additional, Sweedler, Jonathan V., additional, Szabo, Sandor, additional, Székely, Miklós, additional, Szokodi, István, additional, Taché, Yvette, additional, Takahashi, Kazuhiro, additional, Takei, Yoshio, additional, Takenoya, Fumiko, additional, Talbot, Sébastien, additional, Tallant, E. Ann, additional, Tan, Tricia M., additional, Temmerman, Liesbet, additional, Temmesfeld-Wollbrück, Bettina, additional, Tena-Sempere, Manuel, additional, Thorsell, Annika, additional, Tilakaratne, Nanda, additional, Tobe, Stephen S., additional, Tokudome, Takeshi, additional, Tolstanova, Ganna, additional, Tonon, Marie-Christine, additional, Topping, Jennifer F., additional, Tossi, Alessandro, additional, Tostivint, Hervé, additional, Toth, Istvan, additional, Totsune, Kazuhito, additional, Toyoda, Fumiyo, additional, Troke, Rachel, additional, Tschöp, Matthias H., additional, Tso, Patrick, additional, Tsukaya, Hirokazu, additional, Tsutsui, Kazuyoshi, additional, Tu, Hong, additional, Turner, Anthony J., additional, Ubuka, Takayoshi, additional, Valdivia, Elene R., additional, Vandersmissen, Hans Peter, additional, Vaudry, David, additional, Vaudry, Hubert, additional, Vazquez-Martinez, Rafael, additional, Verbalis, Joseph G., additional, Vicari, Daniele, additional, Vidal, Nicolas, additional, Vignoni, Marzia, additional, Viollet, Cécile, additional, Vishwanatha, K.S., additional, Vivoli, Mirella, additional, Voisin, Thierry, additional, Vu, John P., additional, Walker, John C., additional, Wallace, B.A., additional, Wang, Ji Ming, additional, Wang, Lixin, additional, Wardman, Jonathan H., additional, Watanabe, Takuya, additional, Welch, Hazel, additional, Werner, Haim, additional, Whitmore, L., additional, Wiedemann, Imke, additional, Winsky-Sommerer, Raphaelle, additional, Witt, Ken A., additional, Wojciechowicz, Tatiana, additional, Wong, Jack Ho, additional, Woods, Stephen C., additional, Wootten, Denise, additional, Wu, Vincent, additional, Wurtz, Olivier, additional, Xiong, Ximing, additional, David Xu, Zhi-Qing, additional, Yamaguchi, Yube, additional, Yamaguchi, Takahiro, additional, Yamamoto, Kazutoshi, additional, Yamashita, E., additional, Yamazaki, Hiroyuki, additional, Yang, De, additional, Yoshikawa, Masaaki, additional, Yuan, Pu-Qing, additional, Yung, Sunny C., additional, Zagon, Ian S., additional, Zakharov, S.D., additional, Zaman, Mehfuz, additional, Zhalnina, M.V., additional, Zhang, Ning, additional, Zhang-Auberson, Lixin, additional, Zhao, Chun-Mei, additional, Ziolkowska, Agnieszka, additional, and Zitnan, Dusan, additional

Published
2013
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20. Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP

Author

Krishnamurthy, Balasubramanian, Dudek, Nadine L., McKenzie, Mark D., Purcell, Anthony W., Brooks, Andrew G., Gellert, Shane, Colman, Peter G., Harrison, Leonard C., Lew, Andrew M., Thomas, Helen E., and Kay, Thomas W.H.

Subjects
Autoantigens -- Physiological aspects, Genetically modified mice -- Research, Type 1 diabetes -- Prevention, Type 1 diabetes -- Physiological aspects, Pancreatic beta cells -- Physiological aspects
Abstract

Type 1 diabetes (T1D) is characterized by immune responses against several autoantigens expressed in pancreatic [beta] cells. T cells specific for proinsulin and islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) can [...]

Published
2006

24. The self-peptide repertoire plays a critical role in transplant tolerance induction

Author

Son, Eric T., primary, Faridi, Pouya, additional, Paul-Heng, Moumita, additional, Leong, Mario, additional, English, Kieran, additional, Ramarathinam, Sri H., additional, Braun, Asolina, additional, Dudek, Nadine L., additional, Alexander, Ian E., additional, Lisowski, Leszek, additional, Bertolino, Patrick, additional, Bowen, David G., additional, Purcell, Anthony W., additional, Mifsud, Nicole A., additional, and Sharland, Alexandra F., additional

Published
2020
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34. Defining the HLA class I‐associated viral antigen repertoire from HIV‐1‐infected human cells

Author

Ternette, Nicola, Yang, Hongbing, Partridge, Thomas, Llano, Anuska, Cedeño, Samandhy, Fischer, Roman, Charles, Philip D., Dudek, Nadine L., Mothe, Beatriz, Crespo, Manuel, Fischer, William M., Korber, Bette T. M., Nielsen, Morten, Borrow, Persephone, Purcell, Anthony W., Brander, Christian, Dorrell, Lucy, Kessler, Benedikt M., and Hanke, Tomáš

Subjects
Antigen Processing, Human immunodeficiency virus type I, Human leukocyte antigen, Mass spectrometry, Histocompatibility Antigens Class I, Regular Article, Cytotoxic T cells, Immunopeptidome, Cell Line, Tandem Mass Spectrometry, HIV-1, Humans, Antigens, Viral, Chromatography, High Pressure Liquid, T-Lymphocytes, Cytotoxic
Abstract

Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T-cell responses against pathogens such as HIV-1. We utilized a liquid chromatography tandem mass spectrometry workflow including de novo-assisted database searching to define the HLA class I-associated immunopeptidome of HIV-1-infected human cells. We here report for the first time the identification of 75 HIV-1-derived peptides bound to HLA class I complexes that were purified directly from HIV-1-infected human primary CD4(+) T cells and the C8166 human T-cell line. Importantly, one-third of eluted HIV-1 peptides had not been previously known to be presented by HLA class I. Over 82% of the identified sequences originated from viral protein regions for which T-cell responses have previously been reported but for which the precise HLA class I-binding sequences have not yet been defined. These results validate and expand the current knowledge of virus-specific antigenic peptide presentation during HIV-1 infection and provide novel targets for T-cell vaccine development.

Published
2015

36. Dominant protection from HLA-mediated autoimmune disease is conferred by antigen specific regulatory T cells

Author

Ooi, Joshua D., primary, Petersen, Jan, additional, Tan, Yu H., additional, Huynh, Megan, additional, Willett, Zoe J., additional, Dudek, Nadine L., additional, Eggenhuizen, Peter J., additional, Loh, Khai L., additional, Watson, Katherine A., additional, Gan, Poh-Y., additional, Handel, Andreas, additional, Hudson, Billy G., additional, Fugger, Lars, additional, Power, David A., additional, Holt, Stephen G., additional, Coates, Patrick T., additional, Purcell, Anthony W., additional, Gregersen, Jon W., additional, Holdsworth, Stephen R., additional, La Gruta, Nicole L., additional, Reid, Hugh H., additional, Rossjohn, Jamie, additional, and Kitching, A. Richard, additional

Published
2018
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37. Defining the HLA class I-associated viral antigen repertoire from HIV-1-infected human cells

Author

Ternette, Nicola, Yang, Hongbing, Partridge, Thomas, Llano, Anuska, Cedeño, Samandhy, Fischer, Roman, Charles, Philip D., Dudek, Nadine L., Mothe, Beatriz, Crespo, Manuel, Fischer, William M., Korber, Bette T. M., Nielsen, Morten, Borrow, Persephone, Purcell, Anthony W., Brander, Christian, Dorrell, Lucy, Kessler, Benedikt M., and Hanke, Tomáš

Subjects
MASS SPECTROMETRY, purl.org/becyt/ford/3.3 [https], Salud Ocupacional, CIENCIAS MÉDICAS Y DE LA SALUD, SDG 3 - Good Health and Well-being, Ciencias de la Salud, purl.org/becyt/ford/3 [https], HUMAN LEUKOCYTE ANTIGEN, IMMUNOPEPTIDOME, CYTOTOXIC T CELLS, HUMAN IMMUNODEFICIENCY VIRUS TYPE I
Abstract

Recognition and eradication of infected cells by cytotoxic T lymphocytes is a key defense mechanism against intracellular pathogens. High-throughput definition of HLA class I-associated immunopeptidomes by mass spectrometry is an increasingly important analytical tool to advance our understanding of the induction of T-cell responses against pathogens such as HIV-1. We utilized a liquid chromatography tandem mass spectrometry workflow including de novo-assisted database searching to define the HLA class I-associated immunopeptidome of HIV-1-infected human cells. We here report for the first time the identification of 75 HIV-1-derived peptides bound to HLA class I complexes that were purified directly from HIV-1-infected human primary CD4+ T cells and the C8166 human T-cell line. Importantly, one-third of eluted HIV-1 peptides had not been previously known to be presented by HLA class I. Over 82% of the identified sequences originated from viral protein regions for which T-cell responses have previously been reported but for which the precise HLA class I-binding sequences have not yet been defined. These results validate and expand the current knowledge of virus-specific antigenic peptide presentation during HIV-1 infection and provide novel targets for T-cell vaccine development. Fil: Ternette, Nicola. University of Oxford; Reino Unido Fil: Yang, Hongbing. University of Oxford; Reino Unido Fil: Partridge, Thomas. University of Oxford; Reino Unido Fil: Llano, Anuska. Universitat Autònoma de Barcelona; España Fil: Cedeño, Samandhy. Universitat Autònoma de Barcelona; España Fil: Fischer, Roman. University of Oxford; Reino Unido Fil: Charles, Philip D.. University of Oxford; Reino Unido Fil: Dudek, Nadine L.. Monash University; Australia Fil: Mothe, Beatriz. Hospital Universitari Germans Trias I Pujol; . Universitat Autònoma de Barcelona; España. Hospital Germans Trias i Pujol; España Fil: Crespo, Manuel. Universitat Central de Catalunya; España. Hospital de la Vall d'Hebrón. HIV Unit; España Fil: Fischer, William M.. Los Alamos National High Magnetic Field Laboratory; Estados Unidos Fil: Korber, Bette T. M.. Los Alamos National High Magnetic Field Laboratory; Estados Unidos Fil: Nielsen, Morten. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús). Universidad Nacional de San Martín. Instituto de Investigaciones Biotecnológicas. Instituto de Investigaciones Biotecnológicas "Dr. Raúl Alfonsín" (sede Chascomús); Argentina. Technical University of Denmark; Dinamarca Fil: Borrow, Persephone. University of Oxford; Reino Unido Fil: Purcell, Anthony W.. Monash University; Australia Fil: Brander, Christian. Universitat Autònoma de Barcelona; España. Institució Catalana de Recerca i Estudis Avancats; España. Universitat Central de Catalunya; España Fil: Dorrell, Lucy. University of Oxford; Reino Unido Fil: Kessler, Benedikt M.. University of Oxford; Reino Unido Fil: Hanke, Tomáš. University of Oxford; Reino Unido

Published
2016
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40. Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

Author

Benham, Helen, primary, Nel, Hendrik J., additional, Law, Soi Cheng, additional, Mehdi, Ahmed M., additional, Street, Shayna, additional, Ramnoruth, Nishta, additional, Pahau, Helen, additional, Lee, Bernett T., additional, Ng, Jennifer, additional, G. Brunck, Marion E., additional, Hyde, Claire, additional, Trouw, Leendert A., additional, Dudek, Nadine L., additional, Purcell, Anthony W., additional, O’Sullivan, Brendan J., additional, Connolly, John E., additional, Paul, Sanjoy K., additional, Lê Cao, Kim-Anh, additional, and Thomas, Ranjeny, additional

Published
2015
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42. The cellular redox environment alters antigen presentation

Author

Trujillo, Jonathan A., Croft, Nathan P., Dudek, Nadine L., Channappanavar, Rudragouda, Theodossis, Alex, Webb, Andrew I., Dunstone, Michelle A., Illing, Patricia T., Butler, Noah S., Fett, Craig, Tscharke, David C., Rossjohn, Jamie, Perlman, Stanley, Purcell, Anthony W., Trujillo, Jonathan A., Croft, Nathan P., Dudek, Nadine L., Channappanavar, Rudragouda, Theodossis, Alex, Webb, Andrew I., Dunstone, Michelle A., Illing, Patricia T., Butler, Noah S., Fett, Craig, Tscharke, David C., Rossjohn, Jamie, Perlman, Stanley, and Purcell, Anthony W.

Abstract

Cysteine-containing peptides represent an important class of T cell epitopes, yet their prevalence remains underestimated. We have established and interrogated a database of around 70,000 naturally processed MHC-bound peptides and demonstrate that cysteine-containing peptides are presented on the surface of cells in an MHC allomorph-dependent manner and comprise on average 5-10% of the immunopeptidome. A significant proportion of these peptides are oxidatively modified, most commonly through covalent linkage with the antioxidant glutathione. Unlike some of the previously reported cysteine-based modifications, this represents a true physiological alteration of cysteine residues. Furthermore, our results suggest that alterations in the cellular redox state induced by viral infection are communicated to the immune system through the presentation of S-glutathionylated viral peptides, resulting in altered T cell recognition. Our data provide a structural basis for how the glutathione modification alters recognition by virus-specific T cells. Collectively, these results suggest that oxidative stress represents a mechanism for modulating the virus-specific T cell response.

Published
2014

45. The Cellular Redox Environment Alters Antigen Presentation

Author

Trujillo, Jonathan A., primary, Croft, Nathan P., additional, Dudek, Nadine L., additional, Channappanavar, Rudragouda, additional, Theodossis, Alex, additional, Webb, Andrew I., additional, Dunstone, Michelle A., additional, Illing, Patricia T., additional, Butler, Noah S., additional, Fett, Craig, additional, Tscharke, David C., additional, Rossjohn, Jamie, additional, Perlman, Stanley, additional, and Purcell, Anthony W., additional

Published
2014
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46. Proinsulin-Specific, HLA-DQ8, and HLA-DQ8-Transdimer–Restricted CD4+ T Cells Infiltrate Islets in Type 1 Diabetes

Author

Pathiraja, Vimukthi, primary, Kuehlich, Janine P., additional, Campbell, Peter D., additional, Krishnamurthy, Balasubramanian, additional, Loudovaris, Thomas, additional, Coates, P. Toby H., additional, Brodnicki, Thomas C., additional, O’Connell, Philip J., additional, Kedzierska, Katherine, additional, Rodda, Christine, additional, Bergman, Philip, additional, Hill, Erin, additional, Purcell, Anthony W., additional, Dudek, Nadine L., additional, Thomas, Helen E., additional, Kay, Thomas W.H., additional, and Mannering, Stuart I., additional

Published
2014
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48. A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

Author

Scally, Stephen W., primary, Petersen, Jan, additional, Law, Soi Cheng, additional, Dudek, Nadine L., additional, Nel, Hendrik J., additional, Loh, Khai Lee, additional, Wijeyewickrema, Lakshmi C., additional, Eckle, Sidonia B.G., additional, van Heemst, Jurgen, additional, Pike, Robert N., additional, McCluskey, James, additional, Toes, Rene E., additional, La Gruta, Nicole L., additional, Purcell, Anthony W., additional, Reid, Hugh H., additional, Thomas, Ranjeny, additional, and Rossjohn, Jamie, additional

Published
2013
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