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4. Effect of Obesity on Aquaporin5 Expression in Human Placental and Uterus Tissues.

Author

Kemény, Kata Kira, Kozinszky, Zoltan, Altorjay, Ábel T., Kolcsár, Bálint, Surányi, Andrea, and Ducza, Eszter

Subjects
OXIDANT status, DURATION of pregnancy, BIOTRANSFORMATION (Metabolism), PATHOLOGICAL physiology, CHILDBEARING age
Abstract

Background: Obesity and overweight are also becoming more prevalent among women of childbearing age and pregnant women. In maternal obesity, the activation of metabolic, inflammatory, and oxidative stress pathways is proven, which appears to be a key step in the pathological changes observed in placental and uterine function. Several recent studies have evidenced that aquaporins (AQPs) are critical players in adipose tissue biology and are involved in the onset of obesity. Methods: Our studies aimed to investigate the changes in placental volume and vascularization and measure the AQP5 expression and total antioxidant capacity (TAC) in the placenta and uterus tissues in obese and typical-weight mothers. We also aim to measure the AQP5 plasma concentration. Results: We found AQP5 dominance in the uterus and plasma at 34 weeks of normal pregnancy. The placental volume increased and the vascularization decreased in obese mothers compared to the control. The AQP5 expression increased in the uterus of the obese group and did not change in the placenta. The TAC decreased in the plasma of overweight mothers. Conclusions: We hypothesize that increased AQP5 expression prolongs the length of pregnancy and inhibits the onset of contractions. Based on our findings, we can develop diagnostic tests and provide new targets for tocolytic drug development. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of long-term metformin and liraglutide treatment

Author

Ivić, Vedrana, primary, Zjalić, Milorad, additional, Blažetić, Senka, additional, Fenrich, Matija, additional, Labak, Irena, additional, Scitovski, Rudolf, additional, Szűcs, Kálmán Ferenc, additional, Ducza, Eszter, additional, Tábi, Tamás, additional, Bagamery, Fruzsina, additional, Szökő, Éva, additional, Vuković, Rosemary, additional, Rončević, Alen, additional, Mandić, Dario, additional, Debeljak, Željko, additional, Berecki, Monika, additional, Balog, Marta, additional, Seres-Bokor, Adrienn, additional, Sztojkov-Ivanov, Anita, additional, Hajagos-Tóth, Judit, additional, Gajović, Srećko, additional, Imširović, Alen, additional, Bakula, Marina, additional, Mahiiovych, Solomiia, additional, Gaspar, Robert, additional, Vari, Sandor G., additional, and Heffer, Marija, additional

Published
2023
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11. Elderly rats fed with a high-fat high-sucrose diet developed sex-dependent metabolic syndrome regardless of longterm metformin and liraglutide treatment.

Author

Ivić, Vedrana, Zjalić, Milorad, Blažetić, Senka, Fenrich, Matija, Labak, Irena, Scitovski, Rudolf, Szűcs, Kálmán Ferenc, Ducza, Eszter, Tábi, Tamás, Bagamery, Fruzsina, Szökő, Éva, Vuković, Rosemary, Rončević, Alen, Mandić, Dario, Debeljak, Željko, Berecki, Monika, Balog, Marta, Seres-Bokor, Adrienn, Sztojkov-Ivanov, Anita, and Hajagos-Tóth, Judit

Subjects
HIGH-fat diet, METABOLIC syndrome, LIRAGLUTIDE, METFORMIN, WEIGHT gain, SUCROSE, FRUCTOSE, FAT
Abstract

Aim/Introduction: The study aimed to determine the effectiveness of early antidiabetic therapy in reversing metabolic changes caused by high-fat and high-sucrose diet (HFHSD) in both sexes. Methods: Elderly Sprague-Dawley rats, 45 weeks old, were randomized into four groups: a control group fed on the standard diet (STD), one group fed the HFHSD, and two groups fed the HFHSD along with long-term treatment of either metformin (HFHSD+M) or liraglutide (HFHSD+L). Antidiabetic treatment started 5 weeks after the introduction of the diet and lasted 13 weeks until the animals were 64 weeks old. Results: Unexpectedly, HFHSD-fed animals did not gain weight but underwent significant metabolic changes. Both antidiabetic treatments produced sexspecific effects, but neither prevented the onset of prediabetes nor diabetes. Conclusion: Liraglutide vested benefits to liver and skeletal muscle tissue in males but induced signs of insulin resistance in females. [ABSTRACT FROM AUTHOR]

Published
2023
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15. High Fat High Sucrose Diet Modifies Uterine Contractility and Cervical Resistance in Pregnant Rats: The Roles of Sex Hormones, Adipokines and Cytokines

Author

Gáspár, Róbert, primary, Hajagos-Tóth, Judit, additional, Schaffer, Annamária, additional, Kothencz, Anna, additional, Siska-Szabó, Lilla, additional, Ducza, Eszter, additional, Csányi, Adrienn, additional, Tábi, Tamás, additional, Bagaméry, Fruzsina, additional, Szökő, Éva, additional, Kovács, Orsolya, additional, Barna, Tamara, additional, Samavati, Reza, additional, Mirdamadi, Mohsen, additional, Sztojkov-Ivanov, Anita, additional, Szűcs, Kálmán Ferenc, additional, and Vari, Sandor G., additional

Published
2022
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16. Fentanyl but Not Morphine or Buprenorphine Improves the Severity of Necrotizing Acute Pancreatitis in Rats

Author

Bálint, Emese Réka, primary, Fűr, Gabriella, additional, Kui, Balázs, additional, Balla, Zsolt, additional, Kormányos, Eszter Sára, additional, Orján, Erik Márk, additional, Tóth, Brigitta, additional, Horváth, Gyöngyi, additional, Szűcs, Edina, additional, Benyhe, Sándor, additional, Ducza, Eszter, additional, Pallagi, Petra, additional, Maléth, József, additional, Venglovecz, Viktória, additional, Hegyi, Péter, additional, Kiss, Lóránd, additional, and Rakonczay, Zoltán, additional

Published
2022
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21. Detection of acute stress by smooth muscle electromyography: A translational study on rat and human

Author

Pribék, Ildikó Katalin, primary, Szűcs, Kálmán Ferenc, additional, Süle, Miklós, additional, Grosz, György, additional, Ducza, Eszter, additional, Vigh, Dóra, additional, Tóth, Erika, additional, Janka, Zoltán, additional, Kálmán, János, additional, Datki, Zsolt László, additional, Gáspár, Róbert, additional, and Andó, Bálint, additional

Published
2021
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22. Sex differences in oxidative stress level and antioxidative enzymes expression and activity in obese pre-diabetic elderly rats treated with metformin or liraglutide

Author

Matić, Anita, Vuković, Rosemary, Heffer, Marija, Balog, Marta, Ivić, Vedrana, Gaspar, Robert, Ducza, Eszter, Szucs, Kalman F., Seres, Adrienn, Vari, Sandor G., Drenjančević, Ines, Matić, Anita, Vuković, Rosemary, Heffer, Marija, Balog, Marta, Ivić, Vedrana, Gaspar, Robert, Ducza, Eszter, Szucs, Kalman F., Seres, Adrienn, Vari, Sandor G., and Drenjančević, Ines

Abstract

Aim To determine the effects of metformin or liraglutide on oxidative stress level and antioxidative enzymes gene ex - pression and activity in the blood and vessels of pre-diabet - ic obese elderly Sprague-Dawley (SD) rats of both sexes. Methods Male and female SD rats were assigned to the following groups: a) control group (fed with standard ro - dent chow); b) high-fat and high-carbohydrate diet (HSHFD) group fed with HSHFD from 20-65 weeks of age; c) HSHFD+metformin treatment (50 mg/kg/d s.c.); and d) HSHFD+liraglutide treatment (0.3 mg/kg/d s.c). Oxidative stress parameters (ferric reducing ability of plasma and thiobarbituric acid reactive substances) and superoxide dis - mutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activity and gene expression were determined from serum, aortas, and surface brain blood vessels (BBV). Results HSHFD increased body weight in both sexes com - pared with the control group, while liraglutide prevented this increase. Blood glucose level did not change. The lira - glutide group had a significantly increased antioxidative ca - pacity compared with the HSHFD group in both sexes. The changes in antioxidative enzymes’ activities in plasma were more pronounced in male groups. The changes in gene ex - pression of antioxidative enzymes were more prominent in microvessels and may be attributed to weight gain preven - tion. Conclusions Obesity and antidiabetic drugs caused sexrelated differences in the level of antioxidative parameters. Liraglutide exhibited stronger antioxidative effects than metformin. These results indicate that weight gain due to HSHFD is crucial for developing oxidative stress and for in - hibiting antioxidative protective mechanisms

Published
2021

23. Sex differences in oxidative stress level and antioxidative enzymes expression and activity in obese pre-diabetic elderly rats treated with metformin or liraglutide

Author

Matić, Anita, primary, Vuković, Rosemary, additional, Heffer, Marija, additional, Balog, Marta, additional, Ivić, Vedrana, additional, Gaspar, Robert, additional, Ducza, Eszter, additional, Szucs, Kalman F., additional, Seres, Adrienn, additional, Vari, Sandor G., additional, and Drenjančević, Ines, additional

Published
2021
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31. Preparation and characterization of lamotrigine containing nanocapsules for nasal administration

Author

Gieszinger, Péter, primary, Stefania Csaba, Noemi, additional, Garcia-Fuentes, Marcos, additional, Prasanna, Maruthi, additional, Gáspár, Róbert, additional, Sztojkov-Ivanov, Anita, additional, Ducza, Eszter, additional, Márki, Árpád, additional, Janáky, Tamás, additional, Kecskeméti, Gábor, additional, Katona, Gábor, additional, Szabó-Révész, Piroska, additional, and Ambrus, Rita, additional

Published
2020
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32. Nasal delivery of nanosuspension-based mucoadhesive formulation with improved bioavailability of loratadine: Preparation, characterization, and in vivo evaluation

Author

Alshweiat, Areen, primary, Csóka, IIdikó, additional, Tömösi, Ferenc, additional, Janáky, Tamás, additional, Kovács, Anita, additional, Gáspár, Róbert, additional, Sztojkov-Ivanov, Anita, additional, Ducza, Eszter, additional, Márki, Árpád, additional, Szabó-Révész, Piroska, additional, and Ambrus, Rita, additional

Published
2020
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34. Development of Meloxicam-Human Serum Albumin Nanoparticles for Nose-to-Brain Delivery via Application of a Quality by Design Approach

Author

Katona, Gábor, primary, Balogh, György Tibor, additional, Dargó, Gergő, additional, Gáspár, Róbert, additional, Márki, Árpád, additional, Ducza, Eszter, additional, Sztojkov-Ivanov, Anita, additional, Tömösi, Ferenc, additional, Kecskeméti, Gábor, additional, Janáky, Tamás, additional, Kiss, Tamás, additional, Ambrus, Rita, additional, Pallagi, Edina, additional, Szabó-Révész, Piroska, additional, and Csóka, Ildikó, additional

Published
2020
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39. Transformation of Meloxicam Containing Nanosuspension into Surfactant-Free Solid Compositions to Increase the Product Stability and Drug Bioavailability for Rapid Analgesia

Author

Bartos,Csaba, Ambrus,Rita, Katona,Gábor, Sovány,Tamás, Gáspár,Róbert, Márki,Árpád, Ducza,Eszter, Ivanov,Anita, Tömösi,Ferenc, Janáky,Tamás, Szabó-Révész,Piroska, Bartos,Csaba, Ambrus,Rita, Katona,Gábor, Sovány,Tamás, Gáspár,Róbert, Márki,Árpád, Ducza,Eszter, Ivanov,Anita, Tömösi,Ferenc, Janáky,Tamás, and Szabó-Révész,Piroska

Abstract

Csaba Bartos,1 Rita Ambrus,1 Gábor Katona,1 Tamás Sovány,1 Róbert Gáspár,2 Árpád Márki,3 Eszter Ducza,4 Anita Ivanov,4 Ferenc Tömösi,5 Tamás Janáky,5 Piroska Szabó-Révész1 1Faculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Szeged, Hungary; 2Faculty of Medicine, Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary; 3Faculty of Medicine, Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary; 4Faculty of Pharmacy, Department of Pharmacodynamics and Biopharmacy, University of Szeged, Szeged, Hungary; 5Interdisciplinary Excellence Centre, Department of Medical Chemistry, University of Szeged, Szeged, HungaryCorrespondence: Piroska Szabó-RévészFaculty of Pharmacy, Institute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u 6, Szeged H-6720, HungaryTel +36 62 545 5722Fax +36 62 545 571Email revesz@pharm.u-szeged.huPurpose: The aim of this work was to study the influence of solidification of meloxicam (Mel) containing nanosuspension (nanoMel) on the physical stability and drug bioavailability of the products. The nanoMel sample had poly(vinyl alcohol) (PVA) as a protective polymer, but no surfactant as a further stabilizing agent because the final aim was to produce surfactant-free solid phase products as well.Methods: The solidified samples produced by fluidization and lyophilization (fluidMel, lyoMel) were examined for particle size, crystallinity, and in vitro release of Mel compared to similar parameters of nanoMel. The products were subjected to an animal experiment using per oral administration to verify their bioavailability.Results: Mel containing (1%) nanoMel sample was produced by wet milling p

Published
2019

40. Transformation of Meloxicam Containing Nanosuspension into Surfactant-Free Solid Compositions to Increase the Product Stability and Drug Bioavailability for Rapid Analgesia

Author

Bartos, Csaba, primary, Ambrus, Rita, additional, Katona, Gábor, additional, Sovány, Tamás, additional, Gáspár, Róbert, additional, Márki, Árpád, additional, Ducza, Eszter, additional, Ivanov, Anita, additional, Tömösi, Ferenc, additional, Janáky, Tamás, additional, and Szabó-Révész, Piroska, additional

Published
2019
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41. A Hypercaloric Diet Induces Early Podocyte Damage in Aged, Non-Diabetic Rats.

Author

Seikrit, Claudia, Lausberg, Eva, Buhl, Eva Miriam, Gaspar, Robert, Tabi, Tamas, Heffer, Marija, Ducza, Eszter, Sztojkov-Ivanov, Anita, Seres, Adrienn B., Szucs, Kalman, Ivic, Vedrana, Floege, Jürgen, Vari, Sandor G., Boor, Peter, and Klinkhammer, Barbara Mara

Abstract

Background/Aims: The number of patients of older age with metabolic syndrome, obesity, and associated kidney disease, which is characterized by podocyte damage, glomerular hypertrophy, and focal segmental glomerulosclerosis (FSGS), is increasing worldwide. Animal models that would reflect the development of such kidney diseases could facilitate the testing of drugs. We investigated the renal effects of a long-term high caloric diet in aged rats and the potential effects of drugs used to treat metabolic syndrome. Methods: We analyzed nine-month-old male and female Sprague Dawley rats fed five months with a normal diet (control group) or high-fat-high-carbohydrate diet (HFHCD group). Two additional groups were fed with HFHCD and treated with drugs used in patients with metabolic syndrome, i.e., the glucagon-like peptide receptor 1 agonist liraglutide (HFHCD+liraglutide group) or metformin (HFHCD+metformin group). Results: Except an increase of waist circumference as a sign of visceral obesity, the HFHCD diet did not induce metabolic syndrome or obesity. There were no significant changes in kidney function and all groups showed similar indices of glomerular injury, i.e., no differences in glomerular size or the number of glomeruli with FSGS or with FSGS-precursor lesions quantified by CD44 expression as a marker of parietal epithelial cell (PEC) activation. Analysis of ultrastructural morphology revealed mild podocyte stress and a decrease of glomerular nestin expression in the HFHCD group, whereas podocin and desmin were not altered. HFHCD did not promote fibrogenesis, however, treatment with liraglutide led to a slightly increased tubulointerstitial damage, immune cell infiltration, and collagen IV expression compared to the control and HFHCD groups. Conclusion: A five-month feeding with HFHCD in aged rats induced mild podocyte injury and microinflammation, which was not alleviated by liraglutide or metformin. [ABSTRACT FROM AUTHOR]

Published
2021
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