Search

Your search keyword '"Ducroux, Célina"' showing total 39 results
Start Over Author "Ducroux, Célina"
39 results on '"Ducroux, Célina"'

1. Successful thrombectomy is beneficial in patients with pre-stroke disability: Results from an international multicenter cohort study

Author

Piotin, Michel, Blanc, Raphael, Escalard, Hocine Redjem Simon, Desilles, Jean-Philippe, Delvoye, François, Smajda, Stanislas, Maier, Benjamin, Hebert, Solène, Mazighi, Mikael, Obadia, Mikael, Sabben, Candice, Seners, Pierre, Raynouard, Igor, Corabianu, Ovide, de Broucker, Thomas, Manchon, Eric, Taylor, Guillaume, Ben Maacha, Malek, Thion, Laurie-Anne, Lecler, Augustin, Savatovsky, Julien, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Ajili, Nadia, Lapergue, Bertrand, Weisenburger-Lile, David, Gorza, Lucas, Buard, Géraldine, Coskun, Oguzhan, Consoli, Arturo, Di Maria, Federico, Rodesh, Georges, Zimatore, Sergio, Leguen, Morgan, Gratieux, Julie, Pico, Fernando, Rakotoharinandrasana, Haja, Tassan, Philippe, Poll, Roxanna, Marinier, Sylvie, Nighoghossian, Norbert, Riva, Roberto, Eker, Omer, Turjman, Francis, Derex, Laurent, Cho, Tae-Hee, Mechtouff, Laura, Lukaszewicz, Anne Claire, Philippeau, Frédéric, Cakmak, Serkan, Blanc-Lasserre, Karine, Vallet, Anne-Evelyne, Marnat, Gaultier, Gariel, Florent, Barreau, Xavier, Berge, Jérôme, Menegon, Patrice, Sibon, Igor, Lucas, Ludovic, Olindo, Stéphane, Renou, Pauline, Sagnier, Sharmila, Poli, Mathilde, Debruxelles, Sabrina, Rouanet, François, Tourdias, Thomas, Liegey, Jean-Sebastien, Briau, Pierre, Pangon, Nicolas, Bourcier, Romain, Detraz, Lili, Daumas-Duport, Benjamin, Alexandre, Pierre-Louis, Roy, Monica, Lenoble, Cédric, Desal, Hubert, Guillon, Benoît, de Gaalon, Solène, Preterre, Cécile, Gory, Benjamin, Bracard, Serge, Anxionnat, René, Braun, Marc, Derelle, Anne-Laure, Tonnelet, Romain, Liao, Liang, Zhu, François, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Humbertjean, Lisa, Mione, Gioia, Lacour, Jean-Christophe, Riou-Comte, Nolwenn, Audibert, Gérard, Voicu, Marcela, Alb, Ionel, Reitter, Marie, Brezeanu, Madalina, Masson, Agnès, Tabarna, Adriana, Podar, Iona, Macian-montoro, Francisco, Saleme, Suzanna, Mounayer, Charbel, Rouchaud, Aymeric, Costalat, Vincent, Arquizan, Caroline, Dargazanli, Cyril, Gascou, Grégory, Lefèvre, Pierre-Henri, Derraz, Imad, Riquelme, Carlos, Gaillard, Nicolas, Mourand, Isabelle, Corti, Lucas, Cagnazzo, Federico, ter Schiphorst, Adrien, Francois, Eugene, Vannier, Stéphane, Ferre, Jean-christophe, Raoult, Helene, Ronziere, Thomas, Lassale, Maria, Paya, Christophe, Gauvrit, Jean-Yves, Tracol, Clément, Langnier-Lemercier, Sophie, Samson, Yves, Rosso, Charlotte, Leger, Anne, Deltour, Sandrine, Clarencon, Frederic, Shotar, Eimad, Spelle, Laurent, Denier, Christian, Chassin, Olivier, Chalumeau, Vanessa, Caroff, Jildaz, Venditti, Laura, Naggara, Olivier, Hassen, Wagih Ben, Boulouis, Grégoire, Rodriguez-Régent, Christine, Trystram, Denis, Kerleroux, Basile, Turc, Guillaume, Domigo, Valérie, Lamy, Catherine, Birchenall, Julia, Isabel, Clothilde, Lun, François, Viguier, Alain, Cognard, Christophe, Januel, Anne Christine, Olivot, Jean-Marc, Raposo, Nicolas, Bonneville, Fabrice, Albucher, Jean François, Calviere, Lionel, Darcourt, Jean, Tall, Philippe, Bellanger, Guillaume, Fontaine, Louis, Touze, Emmanuel, Barbier, Charlotte, Schneckenburger, Romain, Boulanger, Marion, Cogez, Julien, Guettier, Sophie, Timsit, Serge, Gentric, Jean-christophe, Ognard, Julien, Merrien, Francois Mathias, Wermester, Ozlem Ozkul, Massardier, Evelyne, Papagiannaki, Chrysanthi, Bourdain, Frédéric, Bernady, Patricia, Lagoarde-Segot, Laurent, Cailliez, Hélène, Veunac, Louis, Higue, David, Wolff, Valérie, Pop, Raoul, Beaujeux, Rémi, Dan-Sorin, Mihoc, Manisor, Monica, Le Bras, Anthony, Evain, Sarah, Le Guen, Arnaud, Richter, Sebastian, Hubrecht, Regis, Demasles, Stéphanie, Barroso, Bruno, Sablot, Denis, Farouil, Geoffroy, Tardieu, Maxime, Smadja, Philippe, Aptel, Sabine, Seiler, Ian, Ducroux, Célina, Nourredine, Mikaïl, Haesebaert, Julie, Buisson, Marielle, Alesefir, Walid, Boisseau, William, Daneault, Nicole, Deschaintre, Yan, Diestro, Jose Danilo B., Eneling, Johanna, Gioia, Laura C., Iancu, Daniella, Jacquin, Grégory, Odier, Céline, Stapf, Christian, Raymond, Jean, Roy, Daniel, Weill, Alain, and Poppe, Alexandre Y.

Published
2023
Full Text
View/download PDF

2. Non-contrast CT markers of intracerebral hematoma expansion: a reliability study

Author

Nehme, Ahmad, Ducroux, Célina, Panzini, Marie-Andrée, Bard, Céline, Bereznyakova, Olena, Boisseau, William, Deschaintre, Yan, Diestro, Jose Danilo Bengzon, Guilbert, François, Jacquin, Grégory, Maallah, Mohamed Taoubane, Nelson, Kristoff, Padilha, Igor Gomes, Poppe, Alexandre Y., Rioux, Bastien, Roy, Daniel, Touma, Lahoud, Weill, Alain, Gioia, Laura C., and Létourneau-Guillon, Laurent

Published
2022
Full Text
View/download PDF

3. Serum glial fibrillary acidic protein in acute stroke: feasibility to determine stroke-type, timeline and tissue-impact.

Author

Paul, Julien F., Ducroux, Célina, Correia, Pamela, Daigneault, Audrey, Larochelle, Catherine, Stapf, Christian, and Gioia, Laura C.

Abstract

Background: Interest is emerging regarding the role of blood biomarkers in acute stroke. The aim of this pilot study was to determine the feasibility of biomarker acquisition in suspected acute stroke, using modern ultrasensitive immunoassay techniques, and explore their potential usefulness for stroke diagnosis and management. Methods: In 62 patients with suspected acute stroke, blood samples were prospectively obtained upon arrival and prior to neuroimaging. Serum levels of glial fibrillary acidic protein (sGFAP) and neurofilament light chain (sNfL) were analyzed using a single molecule array (SIMOA®) method, according to time of symptom onset, neuroimaging, and final diagnosis. Results: Acute ischemic stroke (AIS) was diagnosed in 35 patients, 10 with large-vessel occlusion (LVO). The remaining were diagnosed with intracerebral hemorrhage (ICH) (n = 12), transient ischemic attack (n = 4), and stroke mimics (n = 11). Median (IQR) sGFAP levels were significantly higher in ICH (2,877.8 [1,002.1–10,402.5] pg./mL) compared to others diagnoses. In AIS, GFAP levels appear to increase with longer delays since symptom onset and were higher in patients with more extensive ischemic changes on baseline CT (ASPECTS ≤7) than those without, particularly in LVO stroke. NfL values were similar across groups. Conclusion: In acute stroke, serum GFAP levels show potential as an adjunct tool for the distinction between ICH and AIS. Specific to AIS, GFAP may also offer insight into time from onset, and extent of ischemic tissue injury on neuroimaging, particularly in LVO stroke. These preliminary findings merit further study. [ABSTRACT FROM AUTHOR]

Published
2025
Full Text
View/download PDF

4. Serum glial fibrillary acidic protein in acute stroke: feasibility to determine stroke-type, timeline and tissue-impact.

Author

Paul, Julien F., Ducroux, Célina, Correia, Pamela, Daigneault, Audrey, Larochelle, Catherine, Stapf, Christian, and Gioia, Laura C.

Subjects
HEMORRHAGIC stroke, GLIAL fibrillary acidic protein, TRANSIENT ischemic attack, ISCHEMIC stroke, STROKE
Abstract

Background: Interest is emerging regarding the role of blood biomarkers in acute stroke. The aim of this pilot study was to determine the feasibility of biomarker acquisition in suspected acute stroke, using modern ultrasensitive immunoassay techniques, and explore their potential usefulness for stroke diagnosis and management. Methods: In 62 patients with suspected acute stroke, blood samples were prospectively obtained upon arrival and prior to neuroimaging. Serum levels of glial fibrillary acidic protein (sGFAP) and neurofilament light chain (sNfL) were analyzed using a single molecule array (SIMOA®) method, according to time of symptom onset, neuroimaging, and final diagnosis. Results: Acute ischemic stroke (AIS) was diagnosed in 35 patients, 10 with large-vessel occlusion (LVO). The remaining were diagnosed with intracerebral hemorrhage (ICH) (n = 12), transient ischemic attack (n = 4), and stroke mimics (n = 11). Median (IQR) sGFAP levels were significantly higher in ICH (2,877.8 [1,002.1–10,402.5] pg./mL) compared to others diagnoses. In AIS, GFAP levels appear to increase with longer delays since symptom onset and were higher in patients with more extensive ischemic changes on baseline CT (ASPECTS ≤7) than those without, particularly in LVO stroke. NfL values were similar across groups. Conclusion: In acute stroke, serum GFAP levels show potential as an adjunct tool for the distinction between ICH and AIS. Specific to AIS, GFAP may also offer insight into time from onset, and extent of ischemic tissue injury on neuroimaging, particularly in LVO stroke. These preliminary findings merit further study. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

5. Thrombectomy for Comatose Patients with Basilar Artery Occlusion: A Multicenter Study

Author

Guenego, Adrien, Lucas, Ludovic, Gory, Benjamin, Richard, Sébastien, Aubertin, Mathilde, Weisenburger-Lile, David, Labreuche, Julien, Dargazanli, Cyril, Benali, Amel, Bourcier, Romain, Detraz, Lili, Vannier, Stéphane, Guillen, Maud, Eugene, François, Walker, Gregory, Lun, Ronda, Wormsbecker, Andrew, Ducroux, Célina, Piotin, Michel, Blanc, Raphael, Consoli, Arturo, Lapergue, Bertrand, and Fahed, Robert

Published
2021
Full Text
View/download PDF

7. Clinical uncertainty in large vessel occlusion ischemic stroke: does automated perfusion imaging make a difference? An intra-rater and inter-rater agreement study

Author

Diestro, Jose Danilo Bengzon, Fahed, Robert, Omar, Abdelsimar Tan, Hawkes, Christine, Hendriks, Eef J, Enriquez, Clare, Eesa, Muneer, Stotts, Grant, Lee, Hubert, Nagendra, Shashank, Poppe, Alexandre, Ducroux, Célina, Lim, Timothy, Narvacan, Karl, Rizzuto, Michael, Alfalahi, Afra, Nishi, Hidehisa, Sarma, Pragyan, Itsekson Hayosh, Ze'ev, Ignacio, Katrina, Boisseau, William, Pimenta Ribeiro Pontes Almeida, Eduardo, Benomar, Anass, Almekhlafi, Mohammed A, Milot, Genvieve, Deshmukh, Aviraj, Kishore, Kislay, Tampieri, Donatella, Wang, Jeffrey, Srivastava, Abhilekh, Roy, Daniel, Carpani, Federico, Kashani, Nima, Candale-Radu, Claudia, Singh, Nishita, Bres Bullrich, Maria, Sarmiento, Robert, Muir, Ryan T, Parra-Fariñas, Carmen, Reiter, Stephanie, Deschaintre, Yan, Singh, Ravinder-Jeet, Bodani, Vivek, Katsanos, Aristeidis, Agid, Ronit, Zafar, Atif, Pereira, Vitor M, Spears, Julian, Marotta, Thomas R, Djiadeu, Pascal, Sharma, Sunjay, and Farrokhyar, Forough

Abstract

BackgroundLimited research exists regarding the impact of neuroimaging on endovascular thrombectomy (EVT) decisions for late-window cases of large vessel occlusion (LVO) stroke.ObjectiveT0 assess whether perfusion CT imaging: (1) alters the proportion of recommendations for EVT, and (2) enhances the reliability of EVT decision-making compared with non-contrast CT and CT angiography.MethodsWe conducted a survey using 30 patients drawn from an institutional database of 3144 acute stroke cases. These were presented to 29 Canadian physicians with and without perfusion imaging. We used non-overlapping 95% confidence intervals and difference in agreement classification as criteria to suggest a difference between the Gwet AC1 statistics (κG).ResultsThe percentage of EVT recommendations differed by 1.1% with or without perfusion imaging. Individual decisions changed in 21.4% of cases (11.3% against EVT and 10.1% in favor). Inter-rater agreement (κG) among the 29 raters was similar between non-perfusion and perfusion CT neuroimaging (κG=0.487; 95% CI 0.327 to 0.647 and κG=0.552; 95% CI 0.430 to 0.675). The 95% CIs overlapped with moderate agreement in both. Intra-rater agreement exhibited overlapping 95% CIs for all 28 raters. κGwas either substantial or excellent (0.81–1) for 71.4% (20/28) of raters in both groups.ConclusionsDespite the minimal difference in overall EVT recommendations with either neuroimaging protocol one in five decisions changed with perfusion imaging. Regarding agreement we found that the use of automated CT perfusion images does not significantly impact the reliability of EVT decisions for patients with late-window LVO.

Published
2025
Full Text
View/download PDF

8. Thrombectomy for Basilar Artery Occlusion with Mild Symptoms

Author

Piotin, Michel, Blanc, Raphael, Redjem, Hocine, Escalard, Simon, Desilles, Jean-Philippe, Ciccio, Gabriele, Smajda, Stanislas, Maier, Benjamin, Hebert, Solene, Delvoye, François, Mazighi, Mikael, Obadia, Mikael, Sabben, Candice, Peres, Roxanne, Corabianu, Ovide, de Broucker, Thomas, Smadja, Didier, Alamowitch, Sonia, Ille, Olivier, Manchon, Eric, Garcia, Pierre-Yves, Taylor, Guillaume, Ben Maacha, Malek, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Ajili, Nadia, Lapergue, Bertrand, Weisenburger, David, Gorza, Lucas, Buard, Géraldine, Coskun, Oguzhan, Consoli, Arturo, Di Maria, Federico, Rodesh, Georges, Zimatore, Sergio, Leguen, Morgan, Gratieux, Julie, Pico, Fernando, Rakotoharinandrasana, Haja, Tassan, Philippe, Poll, Roxanna, Marinier, Sylvie, Marnat, Gaultier, Gariel, Florent, Barreau, Xavier, Berge, Jérôme, Veunac, Louis, Menegon, Patrice, Sibon, Igor, Lucas, Ludovic, Olindo, Stéphane, Renou, Pauline, Sagnier, Sharmila, Poli, Mathilde, Debruxelles, Sabrina, Bourcier, Romain, Detraz, Lili, Daumas-Duport, Benjamin, Alexandre, Pierre-Louis, Roy, Monica, Lenoble, Cédric, L'allinec, Vincent, Girot, Jean-Baptiste, Desal, Hubert, Gory, Benjamin, Bracard, Serge, Anxionnat, René, Braun, Marc, Derelle, Anne-Laure, Tonnelet, Romain, Liao, Liang, Zhu, François, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Humbertjean, Lisa, Mione, Gioia, Lacour, Jean-Christophe, Bonnerot, Mathieu, Riou-Comte, Nolwenn, Costalat, Vincent, Arquizan, Caroline, Dargazanli, Cyril, Gascou, Grégory, Lefèvre, Pierre-Henri, Derraz, Imad, Riquelme, Carlos, Gaillard, Nicolas, Mourand, Isabelle, Corti, Lucas, François, Eugene, Vannier, Stéphane, Ferre, Jean-Christophe, Raoult, Helene, Ronziere, Thomas, Lassale, Maria, Paya, Christophe, Gauvrit, Jean-Yves, Tracol, Clément, Langnier-Lemercier, Sophie, Guenego, Adrien, Weisenburger-Lile, David, Ducroux, Célina, Labreuche, Julien, Aubertin, Mathilde, Benali, Amel, Guillen, Maud, Eugene, François, Walker, Gregory, Lun, Ronda, and Fahed, Robert

Published
2021
Full Text
View/download PDF

10. Characteristics of Ischemic Stroke Despite Oral Anticoagulant Use For Atrial Fibrillation

Author

Dubé, Marie-Christine, Ducroux, Célina, Daneault, Nicole, Deschaintre, Yan, Jacquin, Grégory, Odier, Céline, Stapf, Christian, Poppe, Alexandre Y., Romanelli, Giovanni, and Gioia, Laura C.

Abstract

ABSTRACT:Oral anticoagulation (OAC) prevents stroke in atrial fibrillation, yet a residual stroke risk remains. In this single-center retrospective analysis of acute ischemic stroke patients despite OAC, suboptimal OAC treatment is common (30%: inappropriate dosing (17%); patient non-adherence (13%)). Other causes of stroke included OAC interruption (14.5%), a competing stroke mechanism (11.0%), and undetermined breakthrough stroke in 44.5%. Overall, easily modifiable causes of ischemic stroke despite OAC are common. Accordingly, strategies to improve treatment compliance, including appropriate dosing along with guideline-based risk factor and periprocedural OAC management, should be emphasized to improve secondary stroke prevention in this patient population.

Published
2024
Full Text
View/download PDF

11. First-Pass Effect in Basilar Artery Occlusions: Insights From the Endovascular Treatment of Ischemic Stroke Registry

Author

Aubertin, Mathilde, Weisenburger-Lile, David, Gory, Benjamin, Richard, Sébastien, Blanc, Raphael, Ducroux, Célina, Piotin, Michel, Labreuche, Julien, Lucas, Ludovic, Dargazanli, Cyril, Benali, Amel, Bourcier, Romain, Detraz, Lili, Vannier, Stéphane, Guillen, Maud, Eugene, François, Walker, Gregory, Lun, Ronda, Guenego, Adrien, Consoli, Arturo, Marnat, Gaultier, Maier, Benjamin, Lapergue, Bertrand, and Fahed, Robert

Published
2021
Full Text
View/download PDF

16. Successful thrombectomy is beneficial in patients with pre-stroke disability: Results from an international multicenter cohort study

Author

Ducroux, Célina, primary, Derex, Laurent, additional, Nourredine, Mikaïl, additional, Haesebaert, Julie, additional, Buisson, Marielle, additional, Alesefir, Walid, additional, Boisseau, William, additional, Daneault, Nicole, additional, Deschaintre, Yan, additional, Diestro, Jose Danilo B., additional, Eker, Omer, additional, Eneling, Johanna, additional, Gioia, Laura C., additional, Iancu, Daniella, additional, Jacquin, Grégory, additional, Odier, Céline, additional, Stapf, Christian, additional, Raymond, Jean, additional, Roy, Daniel, additional, Weill, Alain, additional, Lapergue, Bertrand, additional, Poppe, Alexandre Y., additional, Piotin, Michel, additional, Blanc, Raphael, additional, Escalard, Hocine Redjem Simon, additional, Desilles, Jean-Philippe, additional, Delvoye, François, additional, Smajda, Stanislas, additional, Maier, Benjamin, additional, Hebert, Solène, additional, Mazighi, Mikael, additional, Obadia, Mikael, additional, Sabben, Candice, additional, Seners, Pierre, additional, Raynouard, Igor, additional, Corabianu, Ovide, additional, de Broucker, Thomas, additional, Manchon, Eric, additional, Taylor, Guillaume, additional, Ben Maacha, Malek, additional, Thion, Laurie-Anne, additional, Lecler, Augustin, additional, Savatovsky, Julien, additional, Wang, Adrien, additional, Evrard, Serge, additional, Tchikviladze, Maya, additional, Ajili, Nadia, additional, Weisenburger-Lile, David, additional, Gorza, Lucas, additional, Buard, Géraldine, additional, Coskun, Oguzhan, additional, Consoli, Arturo, additional, Di Maria, Federico, additional, Rodesh, Georges, additional, Zimatore, Sergio, additional, Leguen, Morgan, additional, Gratieux, Julie, additional, Pico, Fernando, additional, Rakotoharinandrasana, Haja, additional, Tassan, Philippe, additional, Poll, Roxanna, additional, Marinier, Sylvie, additional, Nighoghossian, Norbert, additional, Riva, Roberto, additional, Turjman, Francis, additional, Cho, Tae-Hee, additional, Mechtouff, Laura, additional, Lukaszewicz, Anne Claire, additional, Philippeau, Frédéric, additional, Cakmak, Serkan, additional, Blanc-Lasserre, Karine, additional, Vallet, Anne-Evelyne, additional, Marnat, Gaultier, additional, Gariel, Florent, additional, Barreau, Xavier, additional, Berge, Jérôme, additional, Menegon, Patrice, additional, Sibon, Igor, additional, Lucas, Ludovic, additional, Olindo, Stéphane, additional, Renou, Pauline, additional, Sagnier, Sharmila, additional, Poli, Mathilde, additional, Debruxelles, Sabrina, additional, Rouanet, François, additional, Tourdias, Thomas, additional, Liegey, Jean-Sebastien, additional, Briau, Pierre, additional, Pangon, Nicolas, additional, Bourcier, Romain, additional, Detraz, Lili, additional, Daumas-Duport, Benjamin, additional, Alexandre, Pierre-Louis, additional, Roy, Monica, additional, Lenoble, Cédric, additional, Desal, Hubert, additional, Guillon, Benoît, additional, de Gaalon, Solène, additional, Preterre, Cécile, additional, Gory, Benjamin, additional, Bracard, Serge, additional, Anxionnat, René, additional, Braun, Marc, additional, Derelle, Anne-Laure, additional, Tonnelet, Romain, additional, Liao, Liang, additional, Zhu, François, additional, Schmitt, Emmanuelle, additional, Planel, Sophie, additional, Richard, Sébastien, additional, Humbertjean, Lisa, additional, Mione, Gioia, additional, Lacour, Jean-Christophe, additional, Riou-Comte, Nolwenn, additional, Audibert, Gérard, additional, Voicu, Marcela, additional, Alb, Ionel, additional, Reitter, Marie, additional, Brezeanu, Madalina, additional, Masson, Agnès, additional, Tabarna, Adriana, additional, Podar, Iona, additional, Macian-montoro, Francisco, additional, Saleme, Suzanna, additional, Mounayer, Charbel, additional, Rouchaud, Aymeric, additional, Costalat, Vincent, additional, Arquizan, Caroline, additional, Dargazanli, Cyril, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Derraz, Imad, additional, Riquelme, Carlos, additional, Gaillard, Nicolas, additional, Mourand, Isabelle, additional, Corti, Lucas, additional, Cagnazzo, Federico, additional, ter Schiphorst, Adrien, additional, Francois, Eugene, additional, Vannier, Stéphane, additional, Ferre, Jean-christophe, additional, Raoult, Helene, additional, Ronziere, Thomas, additional, Lassale, Maria, additional, Paya, Christophe, additional, Gauvrit, Jean-Yves, additional, Tracol, Clément, additional, Langnier-Lemercier, Sophie, additional, Samson, Yves, additional, Rosso, Charlotte, additional, Leger, Anne, additional, Deltour, Sandrine, additional, Clarencon, Frederic, additional, Shotar, Eimad, additional, Spelle, Laurent, additional, Denier, Christian, additional, Chassin, Olivier, additional, Chalumeau, Vanessa, additional, Caroff, Jildaz, additional, Venditti, Laura, additional, Naggara, Olivier, additional, Hassen, Wagih Ben, additional, Boulouis, Grégoire, additional, Rodriguez-Régent, Christine, additional, Trystram, Denis, additional, Kerleroux, Basile, additional, Turc, Guillaume, additional, Domigo, Valérie, additional, Lamy, Catherine, additional, Birchenall, Julia, additional, Isabel, Clothilde, additional, Lun, François, additional, Viguier, Alain, additional, Cognard, Christophe, additional, Januel, Anne Christine, additional, Olivot, Jean-Marc, additional, Raposo, Nicolas, additional, Bonneville, Fabrice, additional, Albucher, Jean François, additional, Calviere, Lionel, additional, Darcourt, Jean, additional, Tall, Philippe, additional, Bellanger, Guillaume, additional, Fontaine, Louis, additional, Touze, Emmanuel, additional, Barbier, Charlotte, additional, Schneckenburger, Romain, additional, Boulanger, Marion, additional, Cogez, Julien, additional, Guettier, Sophie, additional, Timsit, Serge, additional, Gentric, Jean-christophe, additional, Ognard, Julien, additional, Merrien, Francois Mathias, additional, Wermester, Ozlem Ozkul, additional, Massardier, Evelyne, additional, Papagiannaki, Chrysanthi, additional, Bourdain, Frédéric, additional, Bernady, Patricia, additional, Lagoarde-Segot, Laurent, additional, Cailliez, Hélène, additional, Veunac, Louis, additional, Higue, David, additional, Wolff, Valérie, additional, Pop, Raoul, additional, Beaujeux, Rémi, additional, Dan-Sorin, Mihoc, additional, Manisor, Monica, additional, Le Bras, Anthony, additional, Evain, Sarah, additional, Le Guen, Arnaud, additional, Richter, Sebastian, additional, Hubrecht, Regis, additional, Demasles, Stéphanie, additional, Barroso, Bruno, additional, Sablot, Denis, additional, Farouil, Geoffroy, additional, Tardieu, Maxime, additional, Smadja, Philippe, additional, Aptel, Sabine, additional, and Seiler, Ian, additional

Published
2023
Full Text
View/download PDF

18. DWI-ASPECTS (Diffusion-Weighted Imaging–Alberta Stroke Program Early Computed Tomography Scores) and DWI-FLAIR (Diffusion-Weighted Imaging–Fluid Attenuated Inversion Recovery) Mismatch in Thrombectomy Candidates: An Intrarater and Interrater Agreement Study

Author

Fahed, Robert, Lecler, Augustin, Sabben, Candice, Khoury, Naim, Ducroux, Célina, Chalumeau, Vanessa, Botta, Daniele, Kalsoum, Erwah, Boisseau, William, Duron, Loïc, Cabral, Dominique, Koskas, Patricia, Benaïssa, Azzedine, Koulakian, Hasmik, Obadia, Michael, Maïer, Benjamin, Weisenburger-Lile, David, Lapergue, Bertrand, Wang, Adrien, Redjem, Hocine, Ciccio, Gabriele, Smajda, Stanislas, Desilles, Jean-Philippe, Mazighi, Mikaël, Ben Maacha, Malek, Akkari, Inès, Zuber, Kevin, Blanc, Raphaël, Raymond, Jean, and Piotin, Michel

Published
2018
Full Text
View/download PDF

21. Three-month functional outcomes following endovascular thrombectomy during the first wave of the COVID-19 pandemic: a Canadian single-center cohort study

Author

Neves Briard, Joel, primary, Dufort, Gabrielle, additional, Jacquin, Grégory, additional, Alesefir, Walid, additional, Bereznyakova, Olena, additional, Boisseau, William, additional, Daneault, Nicole, additional, Deschaintre, Yan, additional, Diestro, Jose Danilo Bengzon, additional, Ducroux, Célina, additional, Eneling, Johanna, additional, Gioia, Laura, additional, Iancu, Daniela E, additional, Odier, Céline, additional, Raymond, Jean, additional, Roy, Daniel, additional, Stapf, Christian, additional, Weill, Alain, additional, and Poppe, Alexandre Y, additional

Published
2021
Full Text
View/download PDF

22. Thrombectomy for Basilar Artery Occlusion with Mild Symptoms

Author

Guenego, Adrien, primary, Dargazanli, Cyril, additional, Weisenburger-Lile, David, additional, Gory, Benjamin, additional, Richard, Sébastien, additional, Ducroux, Célina, additional, Piotin, Michel, additional, Blanc, Raphael, additional, Labreuche, Julien, additional, Lucas, Ludovic, additional, Aubertin, Mathilde, additional, Benali, Amel, additional, Bourcier, Romain, additional, Detraz, Lili, additional, Vannier, Stéphane, additional, Guillen, Maud, additional, Eugene, François, additional, Walker, Gregory, additional, Lun, Ronda, additional, Consoli, Arturo, additional, Lapergue, Bertrand, additional, Fahed, Robert, additional, Redjem, Hocine, additional, Escalard, Simon, additional, Desilles, Jean-Philippe, additional, Ciccio, Gabriele, additional, Smajda, Stanislas, additional, Maier, Benjamin, additional, Hebert, Solene, additional, Delvoye, François, additional, Mazighi, Mikael, additional, Obadia, Mikael, additional, Sabben, Candice, additional, Peres, Roxanne, additional, Corabianu, Ovide, additional, de Broucker, Thomas, additional, Smadja, Didier, additional, Alamowitch, Sonia, additional, Ille, Olivier, additional, Manchon, Eric, additional, Garcia, Pierre-Yves, additional, Taylor, Guillaume, additional, Ben Maacha, Malek, additional, Wang, Adrien, additional, Evrard, Serge, additional, Tchikviladze, Maya, additional, Ajili, Nadia, additional, Weisenburger, David, additional, Gorza, Lucas, additional, Buard, Géraldine, additional, Coskun, Oguzhan, additional, Di Maria, Federico, additional, Rodesh, Georges, additional, Zimatore, Sergio, additional, Leguen, Morgan, additional, Gratieux, Julie, additional, Pico, Fernando, additional, Rakotoharinandrasana, Haja, additional, Tassan, Philippe, additional, Poll, Roxanna, additional, Marinier, Sylvie, additional, Marnat, Gaultier, additional, Gariel, Florent, additional, Barreau, Xavier, additional, Berge, Jérôme, additional, Veunac, Louis, additional, Menegon, Patrice, additional, Sibon, Igor, additional, Olindo, Stéphane, additional, Renou, Pauline, additional, Sagnier, Sharmila, additional, Poli, Mathilde, additional, Debruxelles, Sabrina, additional, Daumas-Duport, Benjamin, additional, Alexandre, Pierre-Louis, additional, Roy, Monica, additional, Lenoble, Cédric, additional, L'allinec, Vincent, additional, Girot, Jean-Baptiste, additional, Desal, Hubert, additional, Bracard, Serge, additional, Anxionnat, René, additional, Braun, Marc, additional, Derelle, Anne-Laure, additional, Tonnelet, Romain, additional, Liao, Liang, additional, Zhu, François, additional, Schmitt, Emmanuelle, additional, Planel, Sophie, additional, Humbertjean, Lisa, additional, Mione, Gioia, additional, Lacour, Jean-Christophe, additional, Bonnerot, Mathieu, additional, Riou-Comte, Nolwenn, additional, Costalat, Vincent, additional, Arquizan, Caroline, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Derraz, Imad, additional, Riquelme, Carlos, additional, Gaillard, Nicolas, additional, Mourand, Isabelle, additional, Corti, Lucas, additional, François, Eugene, additional, Ferre, Jean-Christophe, additional, Raoult, Helene, additional, Ronziere, Thomas, additional, Lassale, Maria, additional, Paya, Christophe, additional, Gauvrit, Jean-Yves, additional, Tracol, Clément, additional, and Langnier-Lemercier, Sophie, additional

Published
2021
Full Text
View/download PDF

23. Early Impact of the COVID-19 Pandemic on Acute Stroke Treatment Delays

Author

Neves Briard, Joel, primary, Ducroux, Célina, additional, Jacquin, Grégory, additional, Alesefir, Walid, additional, Boisseau, William, additional, Daneault, Nicole, additional, Deschaintre, Yan, additional, Eneling, Johanna, additional, Gioia, Laura C., additional, Iancu, Dana, additional, Odier, Céline, additional, Raymond, Jean, additional, Roy, Daniel, additional, Stapf, Christian, additional, Weill, Alain, additional, and Poppe, Alexandre Y., additional

Published
2020
Full Text
View/download PDF

24. Embolus Retriever with Interlinked Cages (ERIC) versus conventional stent retrievers for thrombectomy: a propensity score-based analysis

Author

Ducroux, Célina, primary, Renaud, Nicolas, additional, Bourcier, Romain, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Gory, Benjamin, additional, Richard, Sébastien, additional, Dargazanli, Cyril, additional, Arquizan, Caroline, additional, Eugene, Francois, additional, Vannier, Stephane, additional, Labreuche, Julien, additional, Walker, Gregory, additional, Blanc, Raphaël, additional, Obadia, Mickael, additional, Consoli, Arturo, additional, Lapergue, Bertrand, additional, and Fahed, Robert, additional

Published
2020
Full Text
View/download PDF

25. Three-month functional outcomes following endovascular thrombectomy during the first wave of the COVID-19 pandemic: a Canadian single-center cohort study.

Author

Briard, Joel Neves, Dufort, Gabrielle, Jacquin, Grégory, Alesefir, Walid, Bereznyakova, Olena, Boisseau, William, Daneault, Nicole, Deschaintre, Yan, Diestro, Jose Danilo Bengzon, Ducroux, Célina, Eneling, Johanna, Gioia, Laura, Iancu, Daniela E., Odier, Céline, Raymond, Jean, Roy, Daniel, Stapf, Christian, Weill, Alain, and Poppe, Alexandre Y.

Subjects
STROKE-related mortality, STROKE, SCIENTIFIC observation, CONFIDENCE intervals, MULTIVARIATE analysis, REGRESSION analysis, VEIN surgery, FUNCTIONAL assessment, TREATMENT delay (Medicine), THROMBECTOMY, DESCRIPTIVE statistics, ENDOVASCULAR surgery, REPERFUSION, DEATH, LOGISTIC regression analysis, ODDS ratio, COVID-19 pandemic, LONGITUDINAL method
Abstract

Background The COVID-19 pandemic has disrupted acute stroke care logistics, including delays in hyperacute management and decreased monitoring following endovascular therapy (EVT). We aimed to assess the impact of the pandemic on 90-day functional outcome among patients treated with EVT. Methods This is an observational cohort study including all patients evaluated for an acute stroke between March 30, 2020 and September 30, 2020 (pandemic cohort) and 2019 (reference cohort) in a highvolume Canadian academic stroke center. We collected baseline characteristics, acute reperfusion treatment and management metrics. For EVT-treated patients, we assessed the modified Rankin score (mRS) at 90 days. We evaluated the impact of the pandemic on a 90-day favourable functional status (defined as mRS 0-2) and death using multivariable logistic regressions. Results Among 383 and 339 patients included in the pandemic and reference cohorts, baseline characteristics were similar. Delays from symptom onset to evaluation and in-house treatment were longer during the early first wave, but returned to reference values in the subsequent months. Among the 127 and 136 EVT-treated patients in each respective cohort, favourable 90-day outcome occurred in 53/99 (53%) vs 52/109 (48%, p=0.40), whereas 22/99 (22%) and 28/109 (26%, p=0.56) patients died. In multivariable regressions, the pandemic period was not associated with 90-day favourable functional status (aOR 1.27, 95% CI 0.60 to 2.56) or death (aOR 0.74, 95% CI 0.33 to 1.63). Conclusion In this single-center cohort study conducted in a Canadian pandemic epicenter, the first 6 months of the COVID-19 pandemic did not impact 90-day functional outcomes or death among EVT-treated patients. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

26. Agreement between core laboratory and study investigators for imaging scores in a thrombectomy trial

Author

Fahed, Robert, Ben Maacha, Malek, Ducroux, Célina, Khoury, Naim, Blanc, Raphaël, Piotin, Michel, Lapergue, Bertrand, Costalat, Vincent, Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpital Foch [Suresnes], CHU Montpellier, and Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)

Subjects
Diagnostic Imaging, Male, medicine.medical_specialty, medicine.medical_treatment, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, Severity of Illness Index, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Cohen's kappa, Primary outcome, Physicians, medicine, Humans, 030212 general & internal medicine, Trial registration, Stroke, Aged, Retrospective Studies, Thrombectomy, Cerebral infarction, business.industry, Clinical Laboratory Techniques, General Medicine, Thrombolysis, Cerebral Infarction, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Research Personnel, Inter-rater reliability, Treatment Outcome, Surgery, Female, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), Radiology, Core laboratory, business, Tomography, X-Ray Computed, 030217 neurology & neurosurgery
Abstract

PurposeWe aimed to assess the agreement between study investigators and the core laboratory (core lab) of a thrombectomy trial for imaging scores.MethodsThe Alberta Stroke Program Early CT Score (ASPECTS), the European Collaborative Acute Stroke Study (ECASS) hemorrhagic transformation (HT) classification, and the Thrombolysis In Cerebral Infarction (TICI) scores as recorded by study investigators were compared with the core lab scores in order to assess interrater agreement, using Cohen’s unweighted and weighted kappa statistics.ResultsThere were frequent discrepancies between study sites and core lab for all the scores. Agreement for ASPECTS and ECASS HT classification was less than substantial, with disagreement occurring in more than one-third of cases. Agreement was higher on MRI-based scores than on CT, and was improved after dichotomization on both CT and MRI. Agreement for TICI scores was moderate (with disagreement occurring in more than 25% of patients), and went above the substantial level (less than 10% disagreement) after dichotomization (TICI 0/1/2a vs 2b/3).ConclusionDiscrepancies between scores assessed by the imaging core lab and those reported by study sites occurred in a significant proportion of patients. Disagreement in the assessment of ASPECTS and day 1 HT scores was more frequent on CT than on MRI. The agreement for the dichotomized TICI score (the trial’s primary outcome) was substantial, with less than 10% of disagreement between study sites and core lab.Trial registration numberNCT02523261, Post-results.

Published
2018
Full Text
View/download PDF

29. Hemorrhagic transformation after stroke: Interrater and intrarater agreement

Author

Guenego, Adrien, primary, Lecler, Augustin, additional, Raymond, Jean, additional, Sabben, Candice, additional, Khoury, Naim, additional, Premat, Kevin, additional, Botta, Daniele, additional, Boisseau, William, additional, Maïer, Benjamin, additional, Ciccio, Gabriele, additional, Redjem, Hocine, additional, Smajda, Stanislas, additional, Ducroux, Célina, additional, Di Meglio, Lucas, additional, Davy, Vincent, additional, Olivot, Jean-Marc, additional, Wang, Adrien, additional, Duplantier, Julien, additional, Roques, Margaux, additional, Krystal, Sidney, additional, Koskas, Patricia, additional, Collin, Adrien, additional, Maacha, Malek Ben, additional, Hamdani, Mylène, additional, Zuber, Kevin, additional, Blanc, Raphaël, additional, Piotin, Michel, additional, and Fahed, Robert, additional

Published
2019
Full Text
View/download PDF

30. Three-month functional outcomes following endovascular thrombectomy during the first wave of the COVID-19 pandemic: a Canadian single-center cohort study

Author

Neves Briard, Joel, Dufort, Gabrielle, Jacquin, Grégory, Alesefir, Walid, Bereznyakova, Olena, Boisseau, William, Daneault, Nicole, Deschaintre, Yan, Diestro, Jose Danilo Bengzon, Ducroux, Célina, Eneling, Johanna, Gioia, Laura, Iancu, Daniela E, Odier, Céline, Raymond, Jean, Roy, Daniel, Stapf, Christian, Weill, Alain, and Poppe, Alexandre Y

Abstract

BackgroundThe COVID-19 pandemic has disrupted acute stroke care logistics, including delays in hyperacute management and decreased monitoring following endovascular therapy (EVT). We aimed to assess the impact of the pandemic on 90-day functional outcome among patients treated with EVT.MethodsThis is an observational cohort study including all patients evaluated for an acute stroke between March 30, 2020 and September 30, 2020 (pandemic cohort) and 2019 (reference cohort) in a high-volume Canadian academic stroke center. We collected baseline characteristics, acute reperfusion treatment and management metrics. For EVT-treated patients, we assessed the modified Rankin score (mRS) at 90 days. We evaluated the impact of the pandemic on a 90-day favourable functional status (defined as mRS 0–2) and death using multivariable logistic regressions.ResultsAmong 383 and 339 patients included in the pandemic and reference cohorts, baseline characteristics were similar. Delays from symptom onset to evaluation and in-house treatment were longer during the early first wave, but returned to reference values in the subsequent months. Among the 127 and 136 EVT-treated patients in each respective cohort, favourable 90-day outcome occurred in 53/99 (53%) vs 52/109 (48%, p=0.40), whereas 22/99 (22%) and 28/109 (26%, p=0.56) patients died. In multivariable regressions, the pandemic period was not associated with 90-day favourable functional status (aOR 1.27, 95% CI 0.60 to 2.56) or death (aOR 0.74, 95% CI 0.33 to 1.63).ConclusionIn this single-center cohort study conducted in a Canadian pandemic epicenter, the first 6 months of the COVID-19 pandemic did not impact 90-day functional outcomes or death among EVT-treated patients.

Published
2022
Full Text
View/download PDF

31. Embolus Retriever with Interlinked Cages (ERIC) versus conventional stent retrievers for thrombectomy: a propensity score-based analysis.

Author

Ducroux, Célina, Renaud, Nicolas, Bourcier, Romain, Marnat, Gaultier, Sibon, Igor, Gory, Benjamin, Richard, Sébastien, Dargazanli, Cyril, Arquizan, Caroline, Eugene, Francois, Vannier, Stephane, Labreuche, Julien, Walker, Gregory, Blanc, Raphaël, Obadia, Mickael, Consoli, Arturo, Lapergue, Bertrand, and Fahed, Robert

Subjects
CLINICAL trials, COMPARATIVE studies, LONGITUDINAL method, MEDICAL cooperation, PROBABILITY theory, RESEARCH, SURGICAL stents, VEIN surgery, TREATMENT effectiveness, THROMBECTOMY
Abstract

Background The Embolus Retriever with Interlinked Cages (ERIC) is one of the latest devices for thrombectomies. It has several architectural features that are supposed to enhance its ability to remove clots and prevent distal emboli. We aimed to compare ERIC with standard stent retrievers (SRs) using propensity score (PS) matching. Methods The clinical and radiological data of all consecutive patients treated with ERIC or standard FDA-approved stent retrievers were collected from a prospective multicenter registry. We compared procedural outcomes (recanalization rates according to the modified Thrombolysis In Cerebral Infarction (mTICI) score and procedural complications) and clinical outcomes (modified Rankin Scale (mRS) and mortality at 3 months). Matching of the populations with PS was performed to account for differences in baseline characteristics. Results A total of 1230 patients were included. In both the PS-matched cohort (195 ERIC patients, 630 SR patients) and the inverse probability of treatment weighting PS-adjusted cohort (206 ERIC patients, 1024 SR patients) there was no difference in terms of successful recanalization (modified TICI score >2b), good clinical outcome (mRS=0-2 or equal to pre-stroke mRS), or mortality at 3 months. Patients treated with first-line ERIC had a higher rate of complete recanalization (mTICI 3); however, they also required more passes and more frequent rescue therapy than the SR patient group. Conclusion In a large multicenter registry with PS matching, the ERIC device provided equivalent angiographic and clinical results to conventional SRs. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

32. Visual assessment of diffusion weighted imaging infarct volume lacks accuracy and reliability

Author

Khoury, Naim, primary, Dargazanli, Cyril, additional, Guenego, Adrien, additional, Zuber, Kevin, additional, Ekmen, Asya, additional, Charbonnier, Guillaume, additional, Hebert, Solène, additional, Capron, Jean, additional, Sabben, Candice, additional, Morvan, Erwan, additional, Boisseau, William, additional, Maier, Benjamin, additional, Premat, Kévin, additional, Clarençon, Frédéric, additional, Smajda, Stanislas, additional, Redjem, Hocine, additional, Chalumeau, Vanessa, additional, Boulouis, Gregoire, additional, Chetrit, Annaëlle, additional, Lecler, Augustin, additional, Koskas, Patricia, additional, Duron, Loic, additional, Ciccio, Gabriele, additional, Ducroux, Célina, additional, Escalard, Simon, additional, Desilles, Jean Philippe, additional, Hamdani, Mylène, additional, Lapergue, Bertrand, additional, Mazighi, Mikael, additional, Ben Maacha, Malek, additional, Brikci-Nigassa, Nahida, additional, Blanc, Raphael, additional, Piotin, Michel, additional, and Fahed, Robert, additional

Published
2019
Full Text
View/download PDF

33. First pass effect with contact aspiration and stent retrievers in the Aspiration versus Stent Retriever (ASTER) trial.

Author

Ducroux, Célina, Piotin, Michel, Gory, Benjamin, Labreuche, Julien, Blanc, Raphael, Maacha, Malek Ben, Lapergue, Bertrand, and Fahed, Robert

Subjects
CONFIDENCE intervals, HEALTH outcome assessment, SURGICAL stents, THROMBOLYTIC therapy, THROMBOSIS, VEIN surgery, RANDOMIZED controlled trials, TREATMENT effectiveness, RESPIRATORY aspiration, DATA analysis software, DESCRIPTIVE statistics
Abstract

Background The 'first pass effect' (FPE), which was originally described with stent retrievers, designates a (near-)complete revascularization obtained after a single device pass with no rescue therapy, and is associated with improved clinical outcome and decreased mortality. Objective We report the rate and benefits of FPE in the Aspiration versus Stent Retriever (ASTER) trial. Materials and methods ASTER is a randomized trial comparing angiographic revascularization with the stent retriever (SR) and contact aspiration (CA) thrombectomy techniques, assessed by an external core laboratory using the modified Thrombolysis in Cerebral Infarction (mTICI) scale. Rates of FPE (defined by mTICI 2c/3 after a single pass with no rescue therapy) were compared between patients treated with SR and CA techniques. Outcomes were compared between FPE-SR and FPE-CA patients, and between FPE and non-FPE patients. Results FPE was achieved in 97/336 patients (28.9%), with no significant difference between SR and CA (respectively 53/169 patients (31.3%) vs 44/167 patients (26.3%), adjusted RR for CA versus SR 0.84, 95% CI 0.54 to 1.31; p=0.44). After prespecified adjustment for allocated arm and randomization stratification factors, FPE in patients was associated with a significantly improved clinical outcome and a decreased mortality, and a significantly lower rate of hemorrhagic transformation and procedural complications than in non-FPE patients. Conclusion In the ASTER trial, similar rates of FPE were achieved with SR and CA, and FPE was associated with a significantly improved outcome. New techniques and devices to improve the rate of FPE are warranted. Trial registration number Unique identifier: NCT02523261. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

34. Downstream Microvascular Thrombosis in Cortical Venules Is an Early Response to Proximal Cerebral Arterial Occlusion

Author

Desilles, Jean‐Philippe, primary, Syvannarath, Varouna, additional, Di Meglio, Lucas, additional, Ducroux, Célina, additional, Boisseau, William, additional, Louedec, Liliane, additional, Jandrot‐Perrus, Martine, additional, Michel, Jean‐Baptiste, additional, Mazighi, Mikael, additional, and Ho‐Tin‐Noé, Benoît, additional

Published
2018
Full Text
View/download PDF

35. Testing The Clinical-Imaging Mismatch Selection Criteria of Dawn Trial : There Is Still Room For Improvement in Patient Selection.

Author

Ducroux, Célina and Khoury, Naim

Abstract

ObjectiveWe aimed to conduct an external validation of the selection criteria of the diffusion-weighted-imaging assessment with clinical mismatch in the triage of wake-up and late-presenting strokes undergoing Neurointervention with Trevo (DAWN) trial in a cohort of unknown onset stroke (UOS) patients treated with thrombectomy.MethodsA study cohort of UOS patients was selected from a prospectively collected thrombectomy database. Patients were stratified according to DAWN Groups A/B/C. Group A criteria identified patientsu226580 years old with a NIHSSu226510 + DWI volume

Published
2017

37. Early Impact of the COVID-19 Pandemic on Acute Stroke Treatment Delays

Author

Neves Briard, Joel, Ducroux, Célina, Jacquin, Grégory, Alesefir, Walid, Boisseau, William, Daneault, Nicole, Deschaintre, Yan, Eneling, Johanna, Gioia, Laura C., Iancu, Dana, Odier, Céline, Raymond, Jean, Roy, Daniel, Stapf, Christian, Weill, Alain, and Poppe, Alexandre Y.

Abstract

ABSTRACT:This is an observational cohort study comparing 156 patients evaluated for acute stroke between March 30 and May 31, 2020 at a comprehensive stroke center with 138 patients evaluated during the corresponding time period in 2019. During the pandemic, the proportion of COVID-19 positive patients was low (3%), the time from symptom onset to hospital presentation was significantly longer, and a smaller proportion of patients underwent reperfusion therapy. Among patients directly evaluated at our institution, door-to-needle and door-to-recanalization metrics were significantly longer. Our findings support concerns that the current pandemic may have a negative impact on the management of acute stroke.

Published
2021
Full Text
View/download PDF

38. Endovascular treatment versus medical management for basilar artery occlusion with low-to-moderate symptoms (National Institutes of Health Stroke Scale < 10)

Author

Dargazanli, Cyril, Mourand, Isabelle, Mahmoudi, Mehdi, Poirier, Laurence, Labreuche, Julien, Weisenburger-Lile, David, Gory, Benjamin, Richard, Sébastien, Ducroux, Célina, Piotin, Michel, Blanc, Raphael, Lucas, Ludovic, Marnat, Gaultier, Aubertin, Mathilde, Arquizan, Caroline, Bourcier, Romain, Detraz, Lili, Vannier, Stéphane, Guillen, Maud, Eugene, François, Walker, Gregory, Lun, Ronda, Dowlatshahi, Dariush, Shamy, Michel, Consoli, Arturo, Costalat, Vincent, Lapergue, Bertrand, Maïer, Benjamin, Guenego, Adrien, and Fahed, Robert

Abstract

Background: Patients with acute basilar artery occlusion (BAO) and low-to-moderate symptoms (National Institutes of Health Stroke Scale [NIHSS] < 10) are poorly represented in thrombectomy trials. Our objective is to compare thrombectomy and best medical management (BMT) in this population.Methods: We compared data of all consecutive patients presenting with an initial NIHSS < 10 and acute symptomatic BAO included in two registries. The main outcome was the proportion of patients achieving a 3-months favorable outcome (mRS 0-2 or equal to the pre-stroke value). Secondary outcomes included the proportion of patients with an excellent outcome (mRS 0-1 or equal to pre-stroke value), overall mRs distribution (shift analysis) and mortality. Effect sizes for thrombectomy versus BMT alone were calculated using binary or ordinal logistic regression model before after considering confounders using the inverse probability of treatment weighting (IPTW) propensity score method.Results: One hundred twenty-seven patients were included: sixty-four patients treated with thrombectomy (mean ± SD age: 63.4 ± 16.1) and sixty-three with BMT (mean ± SD age: 69.0 ± 14.3). There was no significant difference between groups for the rate of 3 month-favorable outcome or mortality. After propensity-score adjustment, thrombectomy was associated with a significantly higher chance of excellent outcome at 3 months (mRS 0-1 or equal to pre-stroke value; adjusted OR, 2.68; 95%CI, 1.04–6.90; p= 0.041).Conclusion: Our study suggests that thrombectomy in patients with low-to-moderate symptoms (NIHSS < 10) due to BAO does not improve the rate of favorable outcome but could lead to a higher chance of excellent outcome at 3 months. Trial Registration: ETIS Registry. http://www.clinicaltrials.govNCT03776877

Published
2024
Full Text
View/download PDF

39. Agreement between core laboratory and study investigators for imaging scores in a thrombectomy trial.

Author

Fahed R, Ben Maacha M, Ducroux C, Khoury N, Blanc R, Piotin M, and Lapergue B

Subjects
Aged, Brain Ischemia therapy, Cerebral Infarction diagnostic imaging, Cerebral Infarction therapy, Diagnostic Imaging methods, Female, Humans, Magnetic Resonance Imaging methods, Magnetic Resonance Imaging standards, Male, Middle Aged, Retrospective Studies, Stroke therapy, Thrombectomy methods, Tomography, X-Ray Computed methods, Tomography, X-Ray Computed standards, Treatment Outcome, Brain Ischemia diagnostic imaging, Clinical Laboratory Techniques standards, Diagnostic Imaging standards, Physicians standards, Research Personnel standards, Severity of Illness Index, Stroke diagnostic imaging
Abstract

Purpose: We aimed to assess the agreement between study investigators and the core laboratory (core lab) of a thrombectomy trial for imaging scores., Methods: The Alberta Stroke Program Early CT Score (ASPECTS), the European Collaborative Acute Stroke Study (ECASS) hemorrhagic transformation (HT) classification, and the Thrombolysis In Cerebral Infarction (TICI) scores as recorded by study investigators were compared with the core lab scores in order to assess interrater agreement, using Cohen's unweighted and weighted kappa statistics., Results: There were frequent discrepancies between study sites and core lab for all the scores. Agreement for ASPECTS and ECASS HT classification was less than substantial, with disagreement occurring in more than one-third of cases. Agreement was higher on MRI-based scores than on CT, and was improved after dichotomization on both CT and MRI. Agreement for TICI scores was moderate (with disagreement occurring in more than 25% of patients), and went above the substantial level (less than 10% disagreement) after dichotomization (TICI 0/1/2a vs 2b/3)., Conclusion: Discrepancies between scores assessed by the imaging core lab and those reported by study sites occurred in a significant proportion of patients. Disagreement in the assessment of ASPECTS and day 1 HT scores was more frequent on CT than on MRI. The agreement for the dichotomized TICI score (the trial's primary outcome) was substantial, with less than 10% of disagreement between study sites and core lab., Trial Registration Number: NCT02523261, Post-results., Competing Interests: Competing interests: None declared., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)

Published
2018
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results