Search

Your search keyword '"Ducrocq, R."' showing total 174 results
Start Over Author "Ducrocq, R."
174 results on '"Ducrocq, R."'

6. Strategy linking several analytical methods of neonatal screening for sickle cell disease

Author

Ducrocq, R, Pascaud, O, Bevier, A, Finet, C, Benkerrou, M, and Elion, J

Subjects
Sickle cell anemia -- Diagnosis, Isoelectric focusing -- Usage, Infants -- Diseases -- Usage, Liquid chromatography -- Usage, Health, Social sciences
Abstract

Abstract Background--The French national programme for the neonatal screening of sickle cell disease (SCD) was set up in 1995. This screening is targeted at newborn infants at risk. Over 5 [...]

Published
2001

15. Hétérogénéité génotypique du déficit en G6PD à l’Ouest de l’Afrique Sub-saharienne

Author

Congrès 2000 de la Société Française d’Hématologie (12-14/03/2000: Paris), Messie, K., Pasquaud, O., Benkerrou, Malika, Belloy, M., Lahary, A., Cotton, Frédéric, Elion, J., Ducrocq, R., Congrès 2000 de la Société Française d’Hématologie (12-14/03/2000: Paris), Messie, K., Pasquaud, O., Benkerrou, Malika, Belloy, M., Lahary, A., Cotton, Frédéric, Elion, J., and Ducrocq, R.

Abstract

Hématologie 2000; 6(HS):45, info:eu-repo/semantics/nonPublished

Published
2000

17. Le dépistage néonatal de la drépanocytose en France métropolitaine

Author

Bardakjian, J, primary, Benkerrou, M, additional, Bernaudin, F, additional, Briard, M.L, additional, Ducrocq, R, additional, Lambilliotte, A, additional, Léna-Russo, D, additional, de Montalembert, M, additional, Thuret, I, additional, Bégué, P, additional, Elion, J, additional, and Galactéros, F, additional

Published
2000
Full Text
View/download PDF

25. Three-Year Follow-Up of Hydroxyurea Treatment in Severely Ill Children with Sickle Cell Disease

Author

de Montalembert, M., primary, Belloy, M., additional, Bernaudin, F., additional, Gouraud, F., additional, Capdeville, R., additional, Mardini, R., additional, Philippe, N., additional, Jais, J. P., additional, Bardakdjian, J., additional, Ducrocq, R., additional, Maier-Redelsperger, M., additional, Elion, J., additional, Labie, D., additional, and Girot, R., additional

Published
1997
Full Text
View/download PDF

26. NEWBORN SCREENING FOR SICLE CELL DISEASE IN FRANCE. 523

Author

Bardakdjian-Michau, J., primary, Galacteros, F., additional, Elion, J., additional, Ducrocq, R., additional, Feingold, J., additional, Farriaux, J. P., additional, Paux, E., additional, Girot, R., additional, Maier-Redelsperger, M., additional, Lena-Russo, D., additional, Giraud, F., additional, Briard, M. L., additional, Rey, J., additional, Dhondt, J. L., additional, and North, M. L., additional

Published
1997
Full Text
View/download PDF

29. La drepanocytose a cotonou: Realites et perspectives

Author

Rahimy, M.C., primary, Ahouignan, G., additional, Gangbo, A., additional, Zohoun, I., additional, Allhonou, E., additional, Can, V., additional, Ducrocq, R., additional, Krishnamoorty, R., additional, Elion, J., additional, and Vilmer, E., additional

Published
1996
Full Text
View/download PDF

33. Variation in fetal hemoglobin parameters and predicted hemoglobin S polymerization in sickle cell children in the first two years of life: Parisian Prospective Study on Sickle Cell Disease

Author

Maier-Redelsperger, M, primary, Noguchi, CT, additional, de Montalembert, M, additional, Rodgers, GP, additional, Schechter, AN, additional, Gourbil, A, additional, Blanchard, D, additional, Jais, JP, additional, Ducrocq, R, additional, and Peltier, JY, additional

Published
1994
Full Text
View/download PDF

36. Foetal haemoglobin in normal healthy adults: relationship with polymorphic sequences cis to the β globin gene.

Author

Zertal-Zidani, S., Ducrocq, R., Sahbatou, M., Satta, D., and Krishnamoorthy, R.

Subjects
*GENETIC markers, *GENE expression, *HUMAN genetics
Abstract

We evaluated the effects of polymorphic markers within the β globin gene cluster on HbF expression in two groups. These groups were randomly selected from a survey of HbF distribution in a large population study of unrelated healthy Algerian adults (n=827). The first group contained individuals with normal HbF levels (0.1-0.5%) and the second group contained individuals with raised HbF levels (0.8-2.3%). Of the various polymorphic markers analysed, only the -309 Gγ A→G, the -158 Gγ C→T, the Gγ IVS2 TC (TG)[sub 9] AG (TG)[sub 2] (CG)[sub 2] and the -540β (AT)[sub 9] T[sub 5] sequence configurations were significantly associated with increased HbF levels. More than 84% of the subjects with elevated HbF levels carried one or several of these four marker configurations, suggesting that the β giobin gene cluster exerts a significant effect on HbF expression in healthy individuals. [ABSTRACT FROM AUTHOR]

Published
2002
Full Text
View/download PDF

40. Special Management of Insulin Lispro in Continuous Subcutaneous Insulin Infusion in Young Diabetic Children: A Randomized Cross-Over Study

Author

Tubiana-Rufi, N., Coutant, R., Bloch, J., Munz-Licha, G., Delcroix, C., Montaud-Raguideau, N., Ducrocq, R., Limal, J.-M., and Czernichow, P.

Abstract

AbstractObjective: To compare the safety, efficacy and management of insulin lispro (LP) with regular human insulin (RH) in young diabetic children treated with continuous subcutaneous insulin infusion (CSII). Study Design: 27 very young diabetic children (age 4.6 ± 2.2 years) treated with CSII participated in an open-label, randomized cross-over multicenter study comparing 2 periods of 16 weeks of CSII with LP or RH. Results: Mean daily basal rate was significantly higher during the LP period (p = 0.04). No differences were seen in changes in HbA1c levels, number of hypoglycemic events, cutaneous infections and catheter occlusions. There was no significant difference between the two treatments for preprandial and postprandial glucose values, although prandial glucose excursions tended to be lower with LP (significant at dinner, p = 0.01). Mean blood glucose levels were significantly higher at 0.00 and 3.00 a.m. during LP therapy (p < 0.05). No episode of ketoacidosis occurred during LP treatment. More parents indicated that LP made their own and the child’s daily life easier (p = 0.02) and preferred LP (p = 0.01). Conclusions: LP in CSII therapy in children is safe, as effective as RH, improved postprandial excursions, met the needs of young children in their daily life well, and gained their parents’ satisfaction and preference. However, a shorter duration of LP resulted in hyperglycemia during the first part of the night, which must be compensated for by increasing nocturnal basal rates during this time.Copyright © 2004 S. Karger AG, Basel

Published
2004

41. Two New Gγ Chain Variants: Hb F-Clamart [γ17(A14)Lys→Asn] and Hb F-Ouled Rabah [γ19(B1)Asn→Lys]

Author

Wajcman, H., Borensztajn, K., Riou, J., Prome, D., Hurtre, D., Bardakdjian, J., Lena-Russo, D., Amouroux, I., and Ducrocq, R.

Abstract

Two new fetal hemoglobin variants affecting the Gγ chain are reported. Hb F-Clamart was found during investigation of a French newborn who presented with a mild microcytemia. the second variant was found during neonatal screening for hemoglobinopathies of 30,000 babies from a population-at-risk living in the Paris region. It was named Hb F-Ouled Rabah because its structural modification and ethnic distribution is similar to that of Hb D-Ouled Rabah [Gγ19(B1)AsnLys]. Hb F-Ouled Rabah is clinically silent and occurs at a frequency of ca. 0.1% in newborns originating from Maghreb. Structural characterization of both variants was done by protein chemistry methods, including amino acids analysis and mass spectrometry.

Published
2000
Full Text
View/download PDF

43. A novel C→A transversion within the distal CCAAT motif of the Gγ-globin gene in the algerian Gγβ+-hereditary persistence of fetal hemoglobin

Author

Zertal-Zidani, S., Merghoub, T., Ducrocq, R., Gerard, N., Satta, D., and Krishnamoorthy, R.

Abstract

Hereditary persistence of fetal hemoglobin (HPFH) is a group of genetically heterogeneous conditions characterized by the continued expression of fetal hemoglobin in adulthood. These constitute natural models for understanding the mechanism(s) of the hemoglobin switch. Many large deletions in the β-globin gene cluster and point mutations in one of the fetal globin gene promoters have been described before. In this study we describe a novel C→A transversion (-114) in the distal CCAAT box of the Gγ-globin gene promoter associated with the Gγβ+-HPFH phenotype in an Algerian family. Individuals heterozygous for this mutation exhibit moderate raise in Hb F levels (0.6-3.5 %). Much higher Hb F levels (3.8- 11.2%) are observed when a β-thalas-semia allele is present in trans to the hereditary persistence of fetal hemoglobin allele. This novel Algerian HPFH mutation further stresses the importance of the distal CCA AT box in the postnatal regulation of γ-globin gene expression.

Published
1999
Full Text
View/download PDF

44. The relative importance of the X-linked FCP locus and beta-globin haplotypes in determining haemoglobin F levels: a study of SS patients homozygous for betaS haplotypes

Author

Chang, Y.P.C., Maier-Redelsperger, M., Smith, K.D., Contu, L., Ducrocq, R., Montalembert, M. de, Belloy, M., Elion, J., Dover, G. J, and Girot, R.

Abstract

Five factors have been hypothesized to influence the 20-fold variation in fetal haemoglobin (Hb F) levels in sickle cell anaemia (SS): age sex, alpha-globin gene number, beta-globin haplotype, and the X-linked F-cell production locus (FCP) that regulates the production of Hb F containing erythrocytes (F cells). We analysed the association of these factors with Hb F levels in 112 SS patients living in France who are homozygous for the three common African beta-globin haplotypes (Benin, Bantu or Central African Republic and Senegal). We found that: (1) FCP accounts for about 40% of the overall variation in Hb F levels, (2) when the FCP influence is removed, beta-globin haplotype is associated with 14% of the remaining Hb F variation, and (3) the other factors have little influence. Comparison with our previous study of SS individuals in Jamaica leads to the following conclusions: (1) the X-linked FCP locus is a major determinant of Hb F levels in SS disease, (2) factors linked to the beta-globin haplotype have only a small effect on the variation in Hb F levels, in either the homozygous or heterozygous state, and (3) approximately half of the variation in Hb F levels still remains to be explained.

Published
1997
Full Text
View/download PDF

48. Importation route of the sickle cell trait into Portugal: contribution of molecular epidemiology

Author

Lavinha, J., Joao Goncalves, Faustino, P., Romão, L., Osório-Almeida, L., Peres, M. J., Picanço, I., Martins, M. C., Ducrocq, R., and Labie, D.

Subjects
Genetics, Population, Phenotype, Haplotypes, Models, Genetic, Portugal, Hemoglobin, Sickle, Mutation, Humans, Polymerase Chain Reaction, Sickle Cell Trait
Abstract

To elucidate the origin and spread of the sickle cell trait into the Portuguese population, we examined nine polymorphic DNA markers within the beta globin gene cluster defining the haplotype. The population sample included 64 sickle-cell-gene-bearing individuals from defined Portuguese-speaking white, black, and Asian Indian populations. The nature and geographic distribution of the different beta S haplotypes in Portugal suggest that the sickle cell trait has been imported twice: between the eighth and the thirteenth centuries from the Mediterranean basin (in association with the Benin haplotype) and after the fifteenth century from black Africa over an Atlantic route (Senegal and Bantu haplotypes).

Catalog

Books, media, physical & digital resources
See catalog results