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1. Qualitative evaluation of motives for acceptance or refusal of early palliative care in patients included in early-phase clinical trials in a French comprehensive cancer center: the PALPHA study

Author

Lochmann, Mathilde, Girodet, Magali, Despax, Johanna, Baudry, Valentine, Duranti, Julie, Mastroianni, Bénédicte, Vanacker, Hélène, Vinceneux, Armelle, Brahmi, Mehdi, Renard, Olivier, Verlingue, Loïc, Amini-Adle, Mona, Swalduz, Aurélie, Gautier, Julien, Ducimetière, Françoise, Anota, Amélie, Cassier, Philippe A., Chvetzoff, Gisèle, and Christophe, Véronique

Published
2024
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2. Alveolar soft part sarcomas in young patients: The French national NETSARC+ network experience

Author

Genevois, Anne-Laure, Carton, Matthieu, Jean-Denis, Myriam, Cyrta, Joanna, Corradini, Nadège, Metayer, Lucy, Chemin-Airiau, Claire, Karanian, Marie, Dufresne, Armelle, Pannier, Stéphanie, El Zein, Sophie, Defachelles, Anne-Sophie, Bompas, Emmanuelle, Gantzer, Justine, Honoré, Charles, Noal, Sabine, Héritier, Sébastien, Guillemet, Cécile, Serre, Jill, Le Loarer, François, Pierron, Gaëlle, Merlin, Marie-Sophie, Anract, Philippe, Gomez-Mascard, Anne, Llacer, Carmen, Ducimetière, Françoise, Toulmonde, Maud, Blay, Jean-Yves, and Orbach, Daniel

Published
2024
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3. Management and outcomes of adolescent and young adult sarcoma patients: results from the French nationwide database NETSARC

Author

Kubicek, Pierre, Cesne, Axel Le, Lervat, Cyril, Toulmonde, Maud, Chevreau, Christine, Duffaud, Florence, Le Nail, Louis-Romée, Morelle, Magali, Gaspar, Nathalie, Vérité, Cécile, Castex, Marie-Pierre, Penel, Nicolas, Saada, Esma, Causeret, Sylvain, Bertucci, François, Perrin, Christophe, Bompas, Emmanuelle, Orbach, Daniel, Laurence, Valérie, Piperno-Neumann, Sophie, Anract, Philippe, Rios, Maria, Gentet, Jean-Claude, Mascard, Éric, Pannier, Stéphanie, Blouin, Pascale, Carrère, Sébastien, Chaigneau, Loïc, Soibinet-Oudot, Pauline, Corradini, Nadège, Boudou-Rouquette, Pascaline, Ruzic, Jean-Christophe, Lebrun-Ly, Valérie, Dubray-Longeras, Pascale, Varatharajah, Sharmini, Lebbe, Céleste, Ropars, Mickaël, Kurtz, Jean-Emmanuel, Guillemet, Cécile, Lotz, Jean-Pierre, Berchoud, Juliane, Cherrier, Grégory, Ducimetière, Françoise, Chemin, Claire, Italiano, Antoine, Honoré, Charles, Desandes, Emmanuel, Blay, Jean-Yves, Gouin, François, and Marec-Bérard, Perrine

Published
2023
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4. Leiomyosarcoma and liposarcoma in young patients: The national netsarc+ network experience

Author

Genevois, Anne-Laure, Carton, Matthieu, Jean-Denis, Myriam, Cyrta, Joanna, Corradini, Nadège, Berlanga, Pablo, Chemin-Airiau, Claire, Honore, Charles, El Zein, Sophie, Defachelles, Anne-Sophie, Bompas, Emmanuelle, Anract, Philippe, Gantzer, Justine, Karanian, Marie, Rome, Angélique, Duffaud, Florence, Chevreau, Christine, Watson, Sarah, Le Cesne, Axel, Llacer, Carmen, Le Loarer, François, Pierron, Gaëlle, Gouin, François, Gomez-Mascard, Anne, Causeret, Sylvain, Ducimetière, Françoise, Kalbacher, Elsa, Toulmonde, Maud, Blay, Jean-Yves, and Orbach, Daniel

Published
2023
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5. Handling missing covariates in observational studies: an illustration with the assessment of prognostic factors of survival outcomes in soft-tissue or visceral sarcomas in irradiated fields (SIF)

Author

Huchet, Noémie, primary, Penel, Nicolas, additional, Bonvalot, Sylvie, additional, Thariat, Juliette, additional, Ducimetière, Françoise, additional, Giraud, Antoine, additional, Toulmonde, Maud, additional, Le Cesne, Axel, additional, Blay, Jean-Yves, additional, and Bellera, Carine, additional

Published
2024
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6. Management of sarcomas in children, adolescents and adults: Interactions in two different age groups under the umbrellas of GSF-GETO and SFCE, with the support of the NETSARC+ network

Author

Bompas, Emmanuelle, Martin, Valentine, Meniai, Fatima, Toulmonde, Maud, Marec-Berard, Perrine, Claude, Line, Ducimetiere, Françoise, Chargari, Cyrus, Minard-Colin, Véronique, Corradini, Nadège, Laurence, Valérie, Piperno-Neumann, Sophie, Defachelles, Anne-Sophie, Bernier, Valérie, Italiano, Antoine, Orbach, Daniel, Blay, Jean-Yves, Gaspar, Nathalie, and Berlanga, Pablo

Published
2021
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7. Connecting the changing metallomic spectrum and survival in sarcoma: a pilot study

Author

Collet, Laetitia, primary, Telouk, Philippe, additional, Albarede, Francis, additional, Girodet, Magali, additional, Maqua, Clémence, additional, Rogasik, Muriel, additional, Ducimetière, Françoise, additional, Tabone-Eglinger, Séverine, additional, Brahmi, Mehdi, additional, Dufresne, Armelle, additional, Thomas, David M, additional, Ballinger, Mandy L, additional, Blay, Jean-Yves, additional, and Ray-Coquard, Isabelle, additional

Published
2023
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8. Determinants of the access to remote specialised services provided by national sarcoma reference centres

Author

Fayet, Yohan, Tétreau, Raphaël, Honoré, Charles, Le Nail, Louis-Romée, Dalban, Cécile, Gouin, François, Causeret, Sylvain, Piperno-Neumann, Sophie, Mathoulin-Pelissier, Simone, Karanian, Marie, Italiano, Antoine, Chaigneau, Loïc, Gantzer, Justine, Bertucci, François, Ropars, Mickael, Saada-Bouzid, Esma, Cordoba, Abel, Ruzic, Jean-Christophe, Varatharajah, Sharmini, Ducimetière, Françoise, Chabaud, Sylvie, Dubray-Longeras, Pascale, Fiorenza, Fabrice, De Percin, Sixtine, Lebbé, Céleste, Soibinet, Pauline, Michelin, Paul, Rios, Maria, Farsi, Fadila, Penel, Nicolas, Bompas, Emmanuelle, Duffaud, Florence, Chevreau, Christine, Le Cesne, Axel, Blay, Jean-Yves, Le Loarer, François, and Ray-Coquard, Isabelle

Published
2021
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9. Evolution of Patterns of Care and Outcomes in the Real-Life Setting for Patients with Metastatic GIST Treated in Three French Expert Centers over Three Decades

Author

Toulmonde, Maud, primary, Dinart, Derek, additional, Brahmi, Mehdi, additional, Verret, Benjamin, additional, Jean-Denis, Myriam, additional, Ducimetière, Françoise, additional, Desolneux, Gregoire, additional, Méeus, Pierre, additional, Palussière, Jean, additional, Buy, Xavier, additional, Bouhamama, Amine, additional, Gillon, Pauline, additional, Dufresne, Armelle, additional, Hénon, Clémence, additional, Le Loarer, François, additional, Karanian, Marie, additional, Ngo, Carine, additional, Mathoulin-Pélissier, Simone, additional, Bellera, Carine, additional, Le Cesne, Axel, additional, Blay, Jean Yves, additional, and Italiano, Antoine, additional

Published
2023
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10. Surgical versus non-surgical approach in primary desmoid-type fibromatosis patients: A nationwide prospective cohort from the French Sarcoma Group

Author

Penel, Nicolas, Le Cesne, Axel, Bonvalot, Sylvie, Giraud, Antoine, Bompas, Emmanuelle, Rios, Maria, Salas, Sébastien, Isambert, Nicolas, Boudou-Rouquette, Pascaline, Honore, Charles, Italiano, Antoine, Ray-Coquard, Isabelle, Piperno-Neumann, Sophie, Gouin, François, Bertucci, François, Ryckewaert, Thomas, Kurtz, Jean-Emmanuel, Ducimetiere, Françoise, Coindre, Jean-Michel, and Blay, Jean-Yves

Published
2017
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12. Structural and Socio-Spatial Determinants Influencing Care and Survival of Patients with a Pancreatic Adenocarcinoma: Results of the PANDAURA Cohort

Author

Roth, Gaël S., primary, Fayet, Yohan, additional, Benmameche-Medjahed, Sakina, additional, Ducimetière, Françoise, additional, Charreton, Amandine, additional, Cropet, Claire, additional, Chabaud, Sylvie, additional, Marion-Audibert, Anne-Marie, additional, Berthelet, Olivier, additional, Walter, Thomas, additional, Adham, Mustapha, additional, Baconnier, Mathieu, additional, Tavan, David, additional, Williet, Nicolas, additional, Artru, Pascal, additional, Huet-Penz, Floriane, additional, Ray-Coquard, Isabelle, additional, Farsi, Fadila, additional, Labrosse, Hélène, additional, and de la Fouchardière, Christelle, additional

Published
2022
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13. Management and Outcomes of Pediatric, Adolescent and Young Adult Sarcoma Patients: Results from the French Nationwide Database NETSARC

Author

Kubicek, Pierre, primary, Cesne, Axel Le, additional, Lervat, Cyril, additional, Toulmonde, Maud, additional, Chevreau, Christine, additional, Duffaud, Florence, additional, Nail, Louis-Romée Le, additional, Morelle, Magali, additional, Gaspar, Nathalie, additional, Vérité, Cécile, additional, Castex, Marie-Pierre, additional, Penel, Nicolas, additional, Saada, Esma, additional, Causeret, Sylvain, additional, Bertucci, François, additional, Perrin, Christophe, additional, Bompas, Emmanuelle, additional, Orbach, Daniel, additional, Laurence, Valérie, additional, Piperno-Neumann, Sophie, additional, Anract, Philippe, additional, Rios, Maria, additional, Gentet, Jean-Claude, additional, Mascard, Éric, additional, Pannier, Stéphanie, additional, Blouin, Pascale, additional, Carrère, Sébastien, additional, Chaigneau, Loïc, additional, Soibinet-Oudot, Pauline, additional, Corradini, Nadège, additional, Boudou-Rouquette, Pascaline, additional, Ruzic, Jean-Christophe, additional, Lebrun-Ly, Valérie, additional, Dubray-Longeras, Pascale, additional, Varatharajah, Sharmini, additional, Lebbe, Céleste, additional, Ropars, Mickaël, additional, Kurtz, Jean-Emmanuel, additional, Guillemet, Cécile, additional, Lotz, Jean-Pierre, additional, Berchoud, Juliane, additional, Cherrier, Grégory, additional, Ducimetière, Françoise, additional, Chemin, Claire, additional, Italiano, Antoine, additional, Honoré, Charles, additional, Desandes, Emmanuel, additional, Blay, Jean-Yves, additional, Gouin, François, additional, and Marec-Bérard, Perrine, additional

Published
2022
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14. No Geographical Inequalities in Survival for Sarcoma Patients in France: A Reference Networks’ Outcome?

Author

Fayet, Yohan, primary, Chevreau, Christine, additional, Decanter, Gauthier, additional, Dalban, Cécile, additional, Meeus, Pierre, additional, Carrère, Sébastien, additional, Haddag-Miliani, Leila, additional, Le Loarer, François, additional, Causeret, Sylvain, additional, Orbach, Daniel, additional, Kind, Michelle, additional, Le Nail, Louis-Romée, additional, Ferron, Gwenaël, additional, Labrosse, Hélène, additional, Chaigneau, Loïc, additional, Bertucci, François, additional, Ruzic, Jean-Christophe, additional, Le Brun Ly, Valérie, additional, Farsi, Fadila, additional, Bompas, Emmanuelle, additional, Noal, Sabine, additional, Vozy, Aurore, additional, Ducoulombier, Agnes, additional, Bonnet, Clément, additional, Chabaud, Sylvie, additional, Ducimetière, Françoise, additional, Tlemsani, Camille, additional, Ropars, Mickaël, additional, Collard, Olivier, additional, Michelin, Paul, additional, Gantzer, Justine, additional, Dubray-Longeras, Pascale, additional, Rios, Maria, additional, Soibinet, Pauline, additional, Le Cesne, Axel, additional, Duffaud, Florence, additional, Karanian, Marie, additional, Gouin, François, additional, Tétreau, Raphaël, additional, Honoré, Charles, additional, Coindre, Jean-Michel, additional, Ray-Coquard, Isabelle, additional, Bonvalot, Sylvie, additional, and Blay, Jean-Yves, additional

Published
2022
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15. Reasons for acceptance and refusal of early palliative care in patients included in early-phase clinical trials in a regional comprehensive cancer centre in France: protocol for a qualitative study

Author

Chvetzoff, Gisele, primary, Girodet, Magali, additional, Despax, Johanna, additional, Baudry, Valentine, additional, Duranti, Julie, additional, Mastroianni, Bénédicte, additional, Vanacker, Hélène, additional, Vinceneux, Armelle, additional, Brahmi, Mehdi, additional, Renard, Olivier, additional, Gautier, Julien, additional, Britel, Manon, additional, Ducimetière, Françoise, additional, Anota, Amélie, additional, Cassier, Philippe, additional, and Christophe, Véronique, additional

Published
2022
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17. Management and Outcomes of Adolescent and Young Adult Sarcoma Patients in the French Multicenter NETSARC Database

Author

Kubicek, Pierre, primary, Le Cesne, Axel, additional, Lervat, Cyril, additional, Toulmonde, Maud, additional, Chevreau, Christine, additional, Duffaud, Florence, additional, Le Nail, Louis-Romée, additional, Morelle, Magali, additional, Gaspar, Nathalie, additional, Vérité, Cécile, additional, Castex, Marie-Pierre, additional, Penel, Nicolas, additional, Saada-Bouzid, Esma, additional, Causeret, Sylvian, additional, Bertucci, François, additional, Perrin, Christophe, additional, Bompas, Emmanuelle, additional, Orbach, Daniel, additional, Piperno-Neumann, Sophie, additional, Anract, Philippe, additional, Rios, Maria, additional, Gentet, Jean-Claude, additional, Mascard, Éric, additional, Pannier, Stéphanie, additional, Blouin, Pascale, additional, Carrère, Sébastien, additional, Chaigneau, Loïc, additional, Soibinet-Oudot, Pauline, additional, Corradini, Nadège, additional, Boudou-Rouquette, Pascaline, additional, Ruzic, Jean-Christophe, additional, Lebrun-ly, Valérie, additional, Dubray-Longeras, Pascale, additional, Varatharajah, Sharmini, additional, Lebbe, Céleste, additional, Ropars, Mickaël, additional, Kurtz, Jean-Emmanuel, additional, Guillemet, Cécile, additional, Lotz, Jean-Pierre, additional, Berchoud, Juliane, additional, Cherrier, Grégory, additional, Ducimetière, Françoise, additional, Chemin, Claire, additional, Italiano, Antoine, additional, Honoré, Charles, additional, Blay, Jean-Yves, additional, Gouin, François, additional, and Marec-Bérard, Perrine, additional

Published
2020
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18. Optimisation du parcours de soins dans la prise en charge initiale des cancers épithéliaux ovariens en France

Author

Perrier, Lionel, Koala, Denis, Huguet, Marius, Morelle, Magali, Augusto, Vincent, Méeus, Pierre, Ducimetière, Françoise, Farsi, Fadila, Ray-Coquard, Isabelle, Groupe d'analyse et de théorie économique (GATE Lyon Saint-Étienne), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure des Mines de St Etienne, Université Lumière - Lyon 2 (UL2), Service d'Oncologie Chirurgicale, Centre Léon Bérard [Lyon], Département d'Oncologie Médicale, Réseau Espace Santé Cancer, Rhône-Alpes, Département de Médecine Nucléaire, Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne (GATE Lyon Saint-Étienne), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE), and Dao, Taï

Subjects
[SHS.ECO] Humanities and Social Sciences/Economics and Finance, [SHS.ECO]Humanities and Social Sciences/Economics and Finance
Abstract

Présenté par Lionel Perrier; International audience

Published
2019

19. Sarcomas in patients over 90: Natural history and treatment—A nationwide study over 6 years

Author

Basse, Clémence, Italiano, Antoine, Penel, Nicolas, Mir, Olivier, Chemin, Claire, Toulmonde, Maud, Duffaud, Florence, Le Cesne, Axel, Chevreau, Christine, Maynou, Carlos, Anract, Philippe, Gouin, François, Rios, Maria, Firmin, Nelly, Kurtz, Jean-Emmanuel, Kerbrat, Pierre, Piperno-Neumann, Sophie, Bertucci, Francois, Rosset, Philippe, Isambert, Nicolas, Bompas, Emmanuelle, Dubray-Longeras, Pascale, Fiorenza, Fabrice, Le Maignan, Christine, Chaigneau, Loic, Thyss, Antoine, Bouché, Olivier, Eymard, Jean-Christophe, Delcambre Lair, Corinne, Adam, Julien, Karanian, Marie, Lebbé, Céleste, Dupré, Aurélien, Méeus, Pierre, Brahmi, Mehdi, Dufresne, Armelle, Ducimetière, Françoise, Ray-Coquard, Isabelle, Blay, Jean-Yves, Kurtz, Jean‐emmanuel, Piperno‐neumann, Sophie, Dubray‐longeras, Pascale, Eymard, Jean‐christophe, Ray‐coquard, Isabelle, Blay, Jean‐yves, Institut Bergonié [Bordeaux], UNICANCER, Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] (UNICANCER/Lille), Université de Lille-UNICANCER, Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), AGROCAMPUS OUEST, Hôpital de la Timone [CHU - APHM] (TIMONE), Département de médecine oncologique [Gustave Roussy], Institut Gustave Roussy (IGR), Institut Claudius Regaud, Physiopathologie des Adaptations Nutritionnelles (PhAN), Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN), Centre Alexis Vautrin (CAV), Département d'oncologie Médicale, CRLCC Val d'Aurelle - Paul Lamarque, Les Hôpitaux Universitaires de Strasbourg (HUS), Service d'Oncologie Médicale [Rennes], CRLCC Eugène Marquis (CRLCC), Département d'Oncologie Médicale [Institut Curie, Paris], Institut Curie [Paris], Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), STeRéO, Institut des Sciences Moléculaires de Marseille (ISM2), Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-École Centrale de Marseille (ECM)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), CRLCC René Gauducheau, Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), Service d'hématologie A [CHU HEGP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Service d'Oncologie Médicale [CHRU Besançon], Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service d'Hématologie, Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA)-UNICANCER-Université Côte d'Azur (UCA), Centre Hospitalier Universitaire de Reims (CHU Reims), Institut Jean Godinot [Reims], Biomarqueurs prédictifs et nouvelles stratégies moléculaires en thérapeutique anticancéreuse (U981), Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Immunologie, dermatologie, oncologie, Oncodermatologie, immunologie et cellules souches cutanées (IDO (U976 / UMR_S 976)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'Oncologie Chirurgicale [Lyon], Centre Léon Bérard [Lyon], Département d'Oncologie Médicale, Service d'Oncologie Médicale, Université Lille Nord de France (COMUE)-UNICANCER, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Paoli-Calmettes, and Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Aix Marseille Université (AMU)

Subjects
Male, Cancer Research, Databases, Factual, [SDV]Life Sciences [q-bio], Soft Tissue Neoplasms, registry, 0302 clinical medicine, Medicine, Registries, Cancer Therapy and Prevention, Child, sarcomas, Aged, 80 and over, relapse, education.field_of_study, Incidence (epidemiology), Sarcoma, Middle Aged, 3. Good health, Natural history, Oncology, 030220 oncology & carcinogenesis, Child, Preschool, Cohort, Female, France, Adult, medicine.medical_specialty, Adolescent, Population, [SDV.CAN]Life Sciences [q-bio]/Cancer, elderly patients, survival, Disease-Free Survival, 03 medical and health sciences, Young Adult, Internal medicine, Humans, education, Pathological, Aged, business.industry, Infant, Newborn, Cancer, Infant, medicine.disease, NETSARC, Clinical trial, progression, Neoplasm Recurrence, Local, business, oncogeriatry, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

Soft tissue sarcomas (STS) are rare tumors accounting for less than 1% of human cancers. While the highest incidence of sarcomas is observed in elderly, this population is often excluded or poorly represented in clinical trials. The present study reports on clinicopathological presentation, and outcome of sarcoma patients over 90 recorded in the Netsarc.org French national database. NETSARC (netsarc.org) is a network of 26 reference sarcoma centers with specialized multidisciplinary tumor board (MDTB), funded by the French National Cancer Institute to improve the outcome of sarcoma patients. Since 2010, presentation to an MDTB, second pathological review, and collection of sarcoma patient characteristics and follow‐up are collected in a database Information of patients registered from January 1, 2010, to December 31, 2016, in NETSARC were collected, analyzed and compared to the younger population. Patients with sarcomas aged >90 have almost exclusively sarcomas with complex genomics (92.0% vs. 66.3%), are less frequently metastatic (5.3% vs. 14·7%) at diagnosis, have more often superficial tumors (39.8% vs. 14.7%), as well as limbs and head and neck sites (75.2% vs. 38.7%) (all p, What's new? While the highest incidence of soft‐tissue sarcoma (STS) is observed in the elderly, this population is often excluded or poorly represented in clinical trials. Therefore, little is known about the characteristics, treatment, and outcomes of STS in these patients. In this study, the authors analyzed numerous clinical characteristics of patients with sarcoma diagnosed at age 91 or older. They conclude that standard STS management and clinical practice guidelines should be followed for these patients if possible.

Published
2019

20. Clinicians' adherence versus non adherence to practice guidelines in the management of patients with sarcoma: a cost-effectiveness assessment in two European regions

Author

Perrier Lionel, Buja Alessandra, Mastrangelo Giuseppe, Vecchiato Antonella, Sandonà Paolo, Ducimetière Françoise, Blay Jean-Yves, Gilly François, Siani Carole, Biron Pierre, Ranchère-Vince Dominique, Decouvelaere Anne-Valérie, Thiesse Philippe, Bergeron Christophe, Dei Tos Angelo, Coindre Jean-Michel, Rossi Carlo, and Ray-Coquard Isabelle

Subjects
Sarcoma, Cancer, Clinical practice guidelines, Adherence, Compliance, Cost-effectiveness, Public aspects of medicine, RA1-1270
Abstract

Abstract Background Although the management of sarcoma is improving, non adherence to clinical practice guidelines (CPGs) remains high, mainly because of the low incidence of the disease and the variety of histological subtypes. Since little is known about the health economics of sarcoma, we undertook a cost-effectiveness analysis (within the CONnective TIssue CAncer NETwork, CONTICANET) comparing costs and outcomes when clinicians adhered to CPGs and when they did not. Methods Patients studied had a histological diagnosis of sarcoma, were older than 15 years, and had been treated in the Rhône-Alpes region of France (in 2005/2006) or in the Veneto region of Italy (in 2007). Data collected retrospectively for the three years after diagnosis were used to determine relapse free survival and health costs (adopting the hospital's perspective and a microcosting approach). All costs were expressed in euros (€) at their 2009 value. A 4% annual discount rate was applied to both costs and effects. The incremental cost-effectiveness ratio (ICER) was expressed as cost per relapse-free year gained when management was compliant with CPGs compared with when it was not. To capture uncertainty surrounding ICER, a probabilistic sensitivity analysis was performed based on a non-parametric bootstrap method. Results A total of 219 patients were included in the study. Compliance with CPGs was observed for 118 patients (54%). Average total costs reached 23,571 euros when treatment was in accordance with CPGs and 27,313 euros when it was not. In relation to relapse-free survival, compliance with CPGs strictly dominates non compliance, i.e. it is both less costly and more effective. Taking uncertainty into account, the probability that compliance with CPGs still strictly dominates was 75%. Conclusions Our findings should encourage physicians to increase their compliance with CPGs and healthcare administrators to invest in the implementation of CPGs in the management of sarcoma.

Published
2012
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21. The cost-saving effect of centralized histological reviews with soft tissue and visceral sarcomas, GIST, and desmoid tumors: The experiences of the pathologists of the French Sarcoma Group

Author

Perrier, Lionel, Rascle, Pauline, Morelle, Magali, Toulmonde, Maud, Ranchere Vince, Dominique, Le Cesne, Axel, Terrier, Philippe, Neuville, Agnès, Méeus, Pierre, Farsi, Fadila, Ducimetière, Françoise, Blay, Jean-Yves, Ray Coquard, Isabelle, Coindre, Jean-Michel, Heymann, Dominique, Groupe d'analyse et de théorie économique (GATE Lyon Saint-Étienne), École normale supérieure - Lyon (ENS Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Centre National de la Recherche Scientifique (CNRS), Institut Bergonié [Bordeaux], UNICANCER, Centre Léon Bérard [Lyon], Département de médecine oncologique [Gustave Roussy], Institut Gustave Roussy (IGR), Département de biologie et pathologie médicales [Gustave Roussy], Service d'Oncologie Chirurgicale, Réseau Espace Santé Cancer, Rhône-Alpes, Département d'Oncologie Médicale, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Plateforme de génétique moléculaire des cancers d'Aquitaine, UNICANCER-UNICANCER, Physiopathologie des Adaptations Nutritionnelles (PhAN), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne (GATE Lyon Saint-Étienne), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), and Institut National de la Recherche Agronomique (INRA)-Université de Nantes (UN)

Subjects
Male, 0301 basic medicine, lcsh:Medicine, Soft Tissue Neoplasms, Kaposi Sarcoma, 0302 clinical medicine, Medicine and Health Sciences, Angiosarcoma, Medicine, Medical diagnosis, Child, lcsh:Science, ComputingMilieux_MISCELLANEOUS, Aged, 80 and over, Observer Variation, Multidisciplinary, GiST, Sarcomas, Fibromatosis, Sarcoma, Health Care Costs, Middle Aged, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, 3. Good health, Fibromatosis, Aggressive, Oncology, Adenomatous Polyposis Coli, Child, Preschool, 030220 oncology & carcinogenesis, Cohort, Female, France, Radiology, Anatomy, Research Article, Adult, medicine.medical_specialty, Histology, Adolescent, Gastrointestinal Stromal Tumors, Ewing Sarcoma, Young Adult, 03 medical and health sciences, Malignant Tumors, Diagnostic Medicine, Cost Savings, Cancer Detection and Diagnosis, Humans, Benign Tumors, Aged, Retrospective Studies, business.industry, lcsh:R, Cancers and Neoplasms, Biology and Life Sciences, Infant, Retrospective cohort study, Odds ratio, medicine.disease, 030104 developmental biology, Abdominal Neoplasms, lcsh:Q, business
Abstract

Objective This study examined the types of discordance occurring in the diagnosis of soft tissue and visceral sarcomas, gastrointestinal stromal tumors (GIST), and desmoid tumors, as well as the economic impact of diagnostic discrepancies. Methods We carried out a retrospective, multicenter analysis using prospectively implemented databases performed on a cohort of patients within the French RRePS network in 2010. Diagnoses were deemed to be discordant based on the 2013 World Health Organization (WHO) classification. Predictive factors of discordant diagnoses were explored. A decision tree was used to assess the expected costs of two strategies of disease management: one based on revised diagnoses after centralized histological review (option 1), the other on diagnoses without centralized review (option 2). Both were defined based on the patient and the disease characteristics, according to national or international guidelines. The time horizon was 12 months and the perspective of the French National Health Insurance (NHI) was retained. Costs were expressed in Euros for 2013. Sensitivity analyses were performed using low and high scenarios that included ± 20% estimates for cost. Results A total of 2,425 patients were included. Three hundred forty-one patients (14%) had received discordant diagnoses. These discordances were determined to mainly be benign tumors diagnosed as sarcomas (n = 124), or non-sarcoma malignant tumors diagnosed as sarcomas (n = 77). The probability of discordance was higher for a final diagnosis of desmoid tumors when compared to liposarcomas (odds ratio = 5.1; 95%CI [2.6–10.4]). The expected costs per patient for the base-case analysis (low- and high-case scenarios) amounted to €8,791 (€7,033 and €10,549, respectively) for option 1 and €8,904 (€7,057 and €10,750, respectively) for option 2. Conclusions Our findings highlight misdiagnoses of sarcomas, which were found to most often be confused with benign tumors. Centralized histological reviews are likely to provide cost-savings for the French NHI.

Published
2018

22. ETIOSARC study : environmental aetiology of sarcomas from a French prospective multicentric population-based case–control study—study protocol

Author

Lacourt, Aude, primary, Amadéo, Brice, additional, Gramond, Céline, additional, Marrer, Emilie, additional, Plouvier, Sandrine, additional, Baldi, Isabelle, additional, Blay, Jean-Yves, additional, Coindre, Jean-Michel, additional, de Pinieux, Gonzague, additional, Gouin, François, additional, Italiano, Antoine, additional, Le Cesne, Axel, additional, Le Loarer, François, additional, Monnereau, Alain, additional, Pellegrin, Isabelle, additional, Penel, Nicolas, additional, Ray-Coquard, Isabelle, additional, Toulmonde, Maud, additional, Ducimetière, Françoise, additional, and Mathoulin-Pélissier, Simone, additional

Published
2019
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23. Geographical Accessibility of the Sarcoma Referral Networks in France. Intermediate Results from the IGéAS Research Program

Author

Fayet, Yohan, primary, Coindre, Jean-Michel, additional, Dalban, Cécile, additional, Gouin, François, additional, De Pinieux, Gonzague, additional, Farsi, Fadila, additional, Ducimetière, Françoise, additional, Chemin-Airiau, Claire, additional, Jean-Denis, Myriam, additional, Chabaud, Sylvie, additional, Blay, Jean-Yves, additional, and Ray-Coquard, Isabelle, additional

Published
2018
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26. Le territoire, générateur d’inégalités face aux cancers. Analyse de la cohorte EMS en Région Rhône-Alpes

Author

Fayet, Yohan, Chasles, Virginie, Ducimetière, Françoise, Ray-Coquard, Isabelle, Chasles, Virginie, Santé Individu Société - SIS (SIS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université Lumière - Lyon 2 (UL2), Département d'Oncologie Médicale, Centre Léon Bérard [Lyon], Service d'Oncologie Médicale, Santé Individu Société (SIS), Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SHS.GEO] Humanities and Social Sciences/Geography, [SHS.GEO]Humanities and Social Sciences/Geography, [SHS] Humanities and Social Sciences, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2016

27. Illustration de partenariat public/privé. Prises en charge des sarcomes des tissus mous en France–une analyse rétrospective de la « base clinico-biologique sarcomes »

Author

Coindre, Jean-Michel, primary, Ducimetière, Françoise, additional, Mathoulin-Pélissier, Simone, additional, Le Cesne, Axel, additional, Rochaix, Philippe, additional, Terrier, Philippe, additional, Longin, Juliette, additional, Bui-Nguyen, Binh, additional, Giraud, A., additional, Fuchs, Justine, additional, and Blay, Jean-Yves, additional

Published
2016
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28. Répondre aux enjeux des cancers rares. Analyse géographique de la cohorte EMS des sarcomes en région Rhône-Alpes

Author

Ducimetière, Françoise, Fayet, Yohan, Chasles, Virginie, Blay, Jean-Yves, Ray-Coquard, Isabelle, Chasles, Virginie, Santé Individu Société (SIS), Université Lumière - Lyon 2 (UL2)-Université Jean Moulin - Lyon 3 (UJML), Université de Lyon-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM), Santé Individu Société - SIS (SIS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Moulin - Lyon 3 (UJML), and Université de Lyon-Université Lumière - Lyon 2 (UL2)

Subjects
[SHS.GEO] Humanities and Social Sciences/Geography, [SHS.GEO]Humanities and Social Sciences/Geography, [SHS] Humanities and Social Sciences, ComputingMilieux_MISCELLANEOUS, [SHS]Humanities and Social Sciences
Abstract

International audience

Published
2014

30. Discordant diagnoses in sarcoma, GIST and desmoide tumour in France: results from the network RREPS

Author

Perrier, Lionel, Ranchère-Vince, Dominique, Terrier, P., Neuville, A., Decouvelaere, Anne-Valérie, Bui, B., Le Cesne, A., Ray-Coquard, Isabelle, Ducimetière, Françoise, Jean-Denis, M., Courreges, J.B., Mesli, N., Morelle, Magali, Plommet, N., Blay, Jean-Yves, Coindre, Jean-Michel, Groupe d'analyse et de théorie économique (GATE Lyon Saint-Étienne), Centre National de la Recherche Scientifique (CNRS)-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Département d'anatomopathologie, biopathologie, Centre Léon Bérard [Lyon], Institut Gustave Roussy (IGR), Plateforme de génétique moléculaire des cancers d'Aquitaine, Institut Bergonié [Bordeaux], UNICANCER-UNICANCER, Département d'Oncologie Médicale, Université de Lyon, Oncogénèse et progression tumorale, Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Médecine Nucléaire, Université Claude Bernard Lyon 1 (UCBL), Service de Pathologie, Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne (GATE Lyon Saint-Étienne), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
diagnoses, sarcoma, RREPS, France, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, ComputingMilieux_MISCELLANEOUS, GIST, desmoide tumour
Abstract

International audience

Published
2012

31. Cluster analysis and principal component analysis to access the variability of data in cost evaluations: methods and applications in oncology

Author

Perrier, Lionel, Buja, Alessandra, Mastrangelo, Giuseppe, Sylvestre-Baron, Patrick, Pauwels, Petrus, Rossi, Carlo, Gilly, François, Ducimetière, Françoise, Favier, Bertrand, Farsi, Fadila, Laramas, Mathieu, de Marliave, Hugues, Collard, Olivier, Cellier, Dominic, Blay, Jean-Yves, Ray-Coquard, Isabelle, Groupe d'analyse et de théorie économique (GATE Lyon Saint-Étienne), Centre National de la Recherche Scientifique (CNRS)-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université Lumière - Lyon 2 (UL2)-École normale supérieure - Lyon (ENS Lyon), Department of Environmental Medicine and Public Health, Universita degli Studi di Padova, Centre Léon Bérard [Lyon], Melanoma and Sarcomas Unit, Veneto Institute of Oncology, Service de Chirurgie Générale et Digestive, Hospices Civils de Lyon (HCL)-Centre Hospitalier Lyon-Sud - RENAPE, Département d'Oncologie Médicale, Department of Pharmacy, Centre hospitalier universitaire de Grenoble (CHU de Grenoble), CHU Grenoble, Merck Serono, Merck & Co. Inc, Oncogénèse et progression tumorale, Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de Médecine Nucléaire, Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Groupe d'Analyse et de Théorie Economique Lyon - Saint-Etienne (GATE Lyon Saint-Étienne), École normale supérieure de Lyon (ENS de Lyon)-Université Lumière - Lyon 2 (UL2)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Centre National de la Recherche Scientifique (CNRS), and Università degli Studi di Padova = University of Padua (Unipd)

Subjects
oncology, cost-evaluation, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2012

32. Transferability of health cost evaluation across locations in oncology: cluster and principal component analysis as an explorative tool

Author

Perrier, Lionel, primary, Buja, Alessandra, additional, Mastrangelo, Giuseppe, additional, Baron, Patrick Sylvestre, additional, Ducimetière, Françoise, additional, Pauwels, Petrus J, additional, Rossi, Carlo Riccardo, additional, Gilly, François Noël, additional, Martin, Amaury, additional, Favier, Bertrand, additional, Farsi, Fadila, additional, Laramas, Mathieu, additional, Baldo, Vincenzo, additional, Collard, Olivier, additional, Cellier, Dominic, additional, Blay, Jean-Yves, additional, and Ray-Coquard, Isabelle, additional

Published
2014
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33. Répondre aux enjeux des cancers rares. Approche géographique de la cohorte EMS des sarcomes en région Rhône-Alpes

Author

Fayet, Yohan, primary, Chasles, Virginie, additional, Ducimetière, Françoise, additional, Collard, Olivier, additional, Berger, Claire, additional, Meeus, Pierre, additional, Ranchère-Vince, Dominique, additional, Thiesse, Philippe, additional, Sunyach, Marie-Pierre, additional, Marec-Bérard, Perrine, additional, Poncet, Lorraine, additional, Cousin, Philippe, additional, Blay, Jean-Yves, additional, and Ray-Coquard, Isabelle, additional

Published
2014
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35. Incidence of Sarcoma Histotypes and Molecular Subtypes in a Prospective Epidemiological Study with Central Pathology Review and Molecular Testing

Author

Ducimetière, Françoise, primary, Lurkin, Antoine, additional, Ranchère-Vince, Dominique, additional, Decouvelaere, Anne-Valérie, additional, Péoc'h, Michel, additional, Istier, Luc, additional, Chalabreysse, Philippe, additional, Muller, Christine, additional, Alberti, Laurent, additional, Bringuier, Pierre-Paul, additional, Scoazec, Jean-Yves, additional, Schott, Anne-Marie, additional, Bergeron, Christophe, additional, Cellier, Dominic, additional, Blay, Jean-Yves, additional, and Ray-Coquard, Isabelle, additional

Published
2011
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36. Costs and compliance with clinical practice guidelines: A pilot study for initial sarcoma treatment

Author

Perrier, Lionel, primary, Cautela, Nicola, additional, Morelle, Magali, additional, Havet, Nathalie, additional, Ducimetière, Françoise, additional, Lurkin, Antoine, additional, Blay, Jean-Yves, additional, Biron, Pierre, additional, Ranchère-Vince, Dominique, additional, Decouvelaere, Anne-Valérie, additional, Thiesse, Philippe, additional, Bergeron, Christophe, additional, Gilly, François, additional, de Laroche, Guy, additional, Cellier, Dominic, additional, Laramas, Mathieu, additional, Philip, Thierry, additional, and Ray-Coquard, Isabelle, additional

Published
2009
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37. Sarcomas in patients over 90: Natural history and treatment-A nationwide study over 6 years.

Author

Basse C, Italiano A, Penel N, Mir O, Chemin C, Toulmonde M, Duffaud F, Le Cesne A, Chevreau C, Maynou C, Anract P, Gouin F, Rios M, Firmin N, Kurtz JE, Kerbrat P, Piperno-Neumann S, Bertucci F, Rosset P, Isambert N, Bompas E, Dubray-Longeras P, Fiorenza F, Le Maignan C, Chaigneau L, Thyss A, Bouché O, Eymard JC, Delcambre Lair C, Adam J, Karanian M, Lebbé C, Dupré A, Meeus P, Brahmi M, Dufresne A, Ducimetière F, Ray-Coquard I, and Blay JY

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Disease-Free Survival, Female, France epidemiology, Humans, Infant, Infant, Newborn, Male, Middle Aged, Neoplasm Recurrence, Local, Sarcoma diagnosis, Sarcoma epidemiology, Soft Tissue Neoplasms diagnosis, Soft Tissue Neoplasms epidemiology, Young Adult, Databases, Factual statistics & numerical data, Registries statistics & numerical data, Sarcoma therapy, Soft Tissue Neoplasms therapy
Abstract

Soft tissue sarcomas (STS) are rare tumors accounting for less than 1% of human cancers. While the highest incidence of sarcomas is observed in elderly, this population is often excluded or poorly represented in clinical trials. The present study reports on clinicopathological presentation, and outcome of sarcoma patients over 90 recorded in the Netsarc.org French national database. NETSARC (netsarc.org) is a network of 26 reference sarcoma centers with specialized multidisciplinary tumor board (MDTB), funded by the French National Cancer Institute to improve the outcome of sarcoma patients. Since 2010, presentation to an MDTB, second pathological review, and collection of sarcoma patient characteristics and follow-up are collected in a database Information of patients registered from January 1, 2010, to December 31, 2016, in NETSARC were collected, analyzed and compared to the younger population. Patients with sarcomas aged >90 have almost exclusively sarcomas with complex genomics (92.0% vs. 66.3%), are less frequently metastatic (5.3% vs. 14·7%) at diagnosis, have more often superficial tumors (39.8% vs. 14.7%), as well as limbs and head and neck sites (75.2% vs. 38.7%) (all p < 0.001). Optimal diagnostic procedures and surgery were less frequently performed in patients over 90 (p < 0.001). These patients were less frequently operated in NETSARC centers, as compared to those of younger age groups including aged 80-90. However, local relapse-free survival, metastatic relapse-free survival and relapse-free survival were not significantly different from those of younger patients, in the whole cohort, as well as in the subgroup of operated patients. As expected overall survival was worse in patients over 90 (p < 0.001). Patients over 90 who were not operated had worse overall survival than younger patients (9.9 vs. 27.3 months, p < 0.001). Patients with STS diagnosed after 90 have distinct clinicopathological features, but comparable relapse-free survival, unless clinical practice guidelines recommendations are not applied. Standard management should be proposed to these patients if oncogeriatric status allows., (© 2019 The Authors. International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.)

Published
2019
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38. Geographical Accessibility of the Referral Networks in France. Intermediate Results from the IGéAS Research Program.

Author

Fayet Y, Coindre JM, Dalban C, Gouin F, De Pinieux G, Farsi F, Ducimetière F, Chemin-Airiau C, Jean-Denis M, Chabaud S, Blay JY, and Ray-Coquard I

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Female, France, Geography, Humans, Infant, Infant, Newborn, Male, Medical Oncology, Middle Aged, Socioeconomic Factors, Specialization, Surveys and Questionnaires, Young Adult, Health Services Accessibility, Referral and Consultation, Sarcoma therapy
Abstract

Rare cancer patients face lower survival and experience delays in diagnosis and therapeutic mismanagement. Considering the specificities of rare cancers, referral networks have been implemented in France to improve the management and survival of patients. The IGéAS research program aims to assess the networks' ability to reduce inequalities. Data analysis of the IGéAS cohort ( n = 20,590, sarcoma diagnosed between 2011 and 2014) by gathering medical data and geographical index will identify risk factors associated with the belated access to expertise or with no access to expertise. Intermediate results show that referral networks give sarcoma patients access to sarcoma expertise despite the remoteness of some of them. Regional expert centers mostly receive requests from within their area while national referral centers receive requests from the whole country. Delays in the access to expertise may be reduced by making outside practitioners more sensitive to the issues of rare cancers. The perception and involvement of outside practitioners in this device will be assessed using a qualitative survey. All the results are discussed and will contribute to design guidelines to improve early access to expertise and reduce inequalities. Results of the IGéAS research program may contribute to the assessment of referral sarcoma networks and provide some useful lessons to improve cancer care management.

Published
2018
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39. The cost-saving effect of centralized histological reviews with soft tissue and visceral sarcomas, GIST, and desmoid tumors: The experiences of the pathologists of the French Sarcoma Group.

Author

Perrier L, Rascle P, Morelle M, Toulmonde M, Ranchere Vince D, Le Cesne A, Terrier P, Neuville A, Meeus P, Farsi F, Ducimetière F, Blay JY, Ray Coquard I, and Coindre JM

Subjects
Abdominal Neoplasms diagnosis, Abdominal Neoplasms economics, Adenomatous Polyposis Coli diagnosis, Adenomatous Polyposis Coli economics, Adolescent, Adult, Aged, Aged, 80 and over, Child, Child, Preschool, Cost Savings economics, Female, Fibromatosis, Aggressive diagnosis, Fibromatosis, Aggressive economics, France, Gastrointestinal Stromal Tumors diagnosis, Gastrointestinal Stromal Tumors economics, Health Care Costs, Humans, Infant, Male, Middle Aged, Observer Variation, Retrospective Studies, Sarcoma diagnosis, Sarcoma economics, Soft Tissue Neoplasms diagnosis, Soft Tissue Neoplasms economics, Young Adult, Abdominal Neoplasms pathology, Adenomatous Polyposis Coli pathology, Cost Savings methods, Fibromatosis, Aggressive pathology, Gastrointestinal Stromal Tumors pathology, Sarcoma pathology, Soft Tissue Neoplasms pathology
Abstract

Objective: This study examined the types of discordance occurring in the diagnosis of soft tissue and visceral sarcomas, gastrointestinal stromal tumors (GIST), and desmoid tumors, as well as the economic impact of diagnostic discrepancies., Methods: We carried out a retrospective, multicenter analysis using prospectively implemented databases performed on a cohort of patients within the French RRePS network in 2010. Diagnoses were deemed to be discordant based on the 2013 World Health Organization (WHO) classification. Predictive factors of discordant diagnoses were explored. A decision tree was used to assess the expected costs of two strategies of disease management: one based on revised diagnoses after centralized histological review (option 1), the other on diagnoses without centralized review (option 2). Both were defined based on the patient and the disease characteristics, according to national or international guidelines. The time horizon was 12 months and the perspective of the French National Health Insurance (NHI) was retained. Costs were expressed in Euros for 2013. Sensitivity analyses were performed using low and high scenarios that included ± 20% estimates for cost., Results: A total of 2,425 patients were included. Three hundred forty-one patients (14%) had received discordant diagnoses. These discordances were determined to mainly be benign tumors diagnosed as sarcomas (n = 124), or non-sarcoma malignant tumors diagnosed as sarcomas (n = 77). The probability of discordance was higher for a final diagnosis of desmoid tumors when compared to liposarcomas (odds ratio = 5.1; 95%CI [2.6-10.4]). The expected costs per patient for the base-case analysis (low- and high-case scenarios) amounted to €8,791 (€7,033 and €10,549, respectively) for option 1 and €8,904 (€7,057 and €10,750, respectively) for option 2., Conclusions: Our findings highlight misdiagnoses of sarcomas, which were found to most often be confused with benign tumors. Centralized histological reviews are likely to provide cost-savings for the French NHI.

Published
2018
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40. [Not Available].

Author

Toulmonde M, Ducimetière F, Jouhet V, Gaudin T, Malfilatre A, Laizet Y, Mathoulin-Pélissier S, Blay JY, and Coindre JM

Subjects
France, Humans, Databases, Factual statistics & numerical data, Sarcoma genetics, Sarcoma pathology, Sarcoma therapy
Abstract

The Big National Databases and Studies on Real World Data: EXAMPLE OF SARCOMAS IN FRANCE: Sarcomas are rare and heterogeneous tumours, and improvement of knowledge and of patient management need to gather and share data and biological material. The French sarcoma database stores in a warehouse clinical, pathological, molecular, therapeutic and follow-up data as well as data on samples and medical practices. This database and the national structured networks constitute major tools for the French Sarcoma Group., (© 2016 Société Française du Cancer. Publié par Elsevier Masson SAS.)

Published
2016
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41. [To answer rare cancer issues. Geographical analysis of EMS sarcoma cohort in the Rhône-Alpes region].

Author

Fayet Y, Chasles V, Ducimetière F, Collard O, Berger C, Meeus P, Ranchère-Vince D, Thiesse P, Sunyach MP, Marec-Bérard P, Poncet L, Cousin P, Blay JY, and Ray-Coquard I

Subjects
Adult, Aged, France epidemiology, Gastrointestinal Stromal Tumors pathology, Humans, Liposarcoma pathology, Middle Aged, Rare Diseases pathology, Gastrointestinal Stromal Tumors epidemiology, Geography, Medical, Liposarcoma epidemiology, Rare Diseases epidemiology
Abstract

Rare cancer issues have not been much explored yet because of their low incidence. That is why epidemiological studies have difficulties in identifying indisputable etiological risk factors. An expert opinion, mainly concentrated in some establishments, is required for these cancers' management. However, on account of the potential remoteness of these therapeutic resources, the patients' way of care remains also unstudied. By means of a geographical analysis of a regional exhaustive cohort of sarcoma, diagnosed in 2006 and 2007 and followed during five years at least, we can make progress on these different issues. Gastro-Intestinal and Stromal Tumors (GIST) occur more frequently in privileged territories while liposarcomas arise in more deprived areas. The association between liposarcomas and areas deprivation is significant (P=0.05). Moreover, pre-operative biopsy and some clinical patient characteristics, age, grade or tumor localization, are associated with an increase in the distance covered by patients for the first-line treatment (p ≤ 0,001). In the scope of an interdisciplinary collaboration, the geographical approach develops some hypothesis for rare cancers research, which must be tested by other larger scale studies.

Published
2014
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42. [Care networks in oncology, an evidence for all?].

Author

Ray-Coquard I, Ducimetière F, and Farsi F

Subjects
Cancer Care Facilities organization & administration, Delivery of Health Care standards, Evidence-Based Practice, France, Humans, Medical Oncology standards, Neoplasms pathology, Pathology, Clinical organization & administration, Rare Diseases pathology, Regional Medical Programs standards, Delivery of Health Care organization & administration, Medical Oncology organization & administration, Neoplasms therapy, Rare Diseases therapy, Regional Medical Programs organization & administration
Published
2013

43. Medical practices and cancer care networks: examples in oncology.

Author

Ray-Coquard I, Chauvin F, Lurkin A, Ducimetière F, Jacquin JP, Agostini C, Pouchard I, Meyer B, Farsi F, Castel P, Perrier L, and Philip T

Subjects
Humans, Quality Assurance, Health Care, Medical Oncology standards, Neoplasms therapy, Practice Patterns, Physicians' trends
Abstract

Understanding medical practices or the whys and wherefores of care decision-making is among the major objectives of medical, economic and sociological research in the current political environment. Although variations of medical practice have long been known to exist, causes and deciding factors remain obscure. This is one of the reasons why medical auditing became widely used in the past years. Using methods similar to those of clinical research, we will explore existing medical practices and their implications, with the aim to propose possible improvements. Elaborating clinical practice guidelines and promoting cancer network activities might prove promising and have a significant impact on clinical practice. This article provides a state-of-the-art overview of the subject, notably in the domain of oncology where substantial advances are being made.

Published
2006

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