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2. First production of X-rays at the ThomX high-intensity Compton source

Author

Jacquet, M, Alexandre, P, Alkadi, M, Alves, M, Amer, M, Amoudry, L, Auguste, D, Babigeon, J, Balcou, P, Baltazar, M, Benabderrahmane, C, el Fekih, R, Benoit, A, Berteaud, P, Biagini, M, Blin, A, Bobault, S, Bonanzingamarco, M, Bonenfant, J, Bonis, J, Bouanani, Y, Bouaziz, S, Bouvet, F, Bravin, A, Bruni, C, Bruyere, C, Bzyl, H, Cassinari, L, Cassou, K, Cayla, J, Chabaud, T, Chaikovska, I, Chance, S, Chapelle, C, Chaumat, V, Chiche, R, Cobessi, A, Cormier, E, Cornebise, P, Couprie, M, Cuoq, R, Dalifard, O, Degallaix, J, Delerue, N, Del Net, W, Diaz, A, Dietrich, Y, Diop, M, Dorkel, R, Douillet, D, Drebot, I, Dugal, J, Dupraz, K, Dupuy, E, El Ajjouri, M, El Kamchi, N, El Khaldi, M, Elleaume, H, Ergenlik, E, Estève, F, Favier, P, Fernandez, M, Gamelin, A, Garaut, J, Garolfi, L, Gauron, P, Gauthier, F, Girault, P, Gonnin, A, Grasset, D, Guerard, E, Guler, H, Haissinski, J, Hazemann, J, Helder, D, Herbeaux, C, Herry, E, Hodeau, J, Horodynski, J, Hubert, N, Iaquaniello, G, Jacquet, P, Jeantet, P, Jehanno, D, Jules, E, Kapoujyan, G, Kubytskyi, V, Labat, M, Labaye, F, Lacipière, J, Lacroix, M, Lahéra, E, Langlet, M, Lebarillec, T, Ledu, J, Le Duc, G, Le Guidec, D, Leluan, B, Lepercq, P, Lestrade, A, Jacquet M., Alexandre P., Alkadi M., Alves M., Amer M., Amoudry L., Auguste D., Babigeon J. L., Balcou P., Baltazar M., Benabderrahmane C., el Fekih R. B., Benoit A., Berteaud P., Biagini M., Blin A., Bobault S., Bonanzingamarco M., Bonenfant J., Bonis J., Bouanani Y., Bouaziz S., Bouvet F., Bravin A., Bruni C., Bruyere C., Bzyl H., Cassinari L., Cassou K., Cayla J. N., Chabaud T., Chaikovska I., Chance S., Chapelle C., Chaumat V., Chiche R., Cobessi A., Cormier E., Cornebise P., Couprie M. E., Cuoq R., Dalifard O., Degallaix J., Delerue N., Del Net W., Diaz A., Dietrich Y., Diop M., Dorkel R., Douillet D., Drebot I., Dugal J. P., Dupraz K., Dupuy E., El Ajjouri M., El Kamchi N., El Khaldi M., Elleaume H., Ergenlik E., Estève F., Favier P., Fernandez M., Gamelin A., Garaut J. F., Garolfi L., Gauron P., Gauthier F., Girault P., Gonnin A., Grasset D., Guerard E., Guler H., Haissinski J., Hazemann J. L., Helder D., Herbeaux C., Herry E., Hodeau J. L., Horodynski J. M., Hubert N., Iaquaniello G., Jacquet P., Jeantet P., Jehanno D., Jules E., Kapoujyan G., Kubytskyi V., Labat M., Labaye F., Lacipière J., Lacroix M., Lahéra E., Langlet M., Lebarillec T., Ledu J. F., Le Duc G., Le Guidec D., Leluan B., Lepercq P., Lestrade A., Jacquet, M, Alexandre, P, Alkadi, M, Alves, M, Amer, M, Amoudry, L, Auguste, D, Babigeon, J, Balcou, P, Baltazar, M, Benabderrahmane, C, el Fekih, R, Benoit, A, Berteaud, P, Biagini, M, Blin, A, Bobault, S, Bonanzingamarco, M, Bonenfant, J, Bonis, J, Bouanani, Y, Bouaziz, S, Bouvet, F, Bravin, A, Bruni, C, Bruyere, C, Bzyl, H, Cassinari, L, Cassou, K, Cayla, J, Chabaud, T, Chaikovska, I, Chance, S, Chapelle, C, Chaumat, V, Chiche, R, Cobessi, A, Cormier, E, Cornebise, P, Couprie, M, Cuoq, R, Dalifard, O, Degallaix, J, Delerue, N, Del Net, W, Diaz, A, Dietrich, Y, Diop, M, Dorkel, R, Douillet, D, Drebot, I, Dugal, J, Dupraz, K, Dupuy, E, El Ajjouri, M, El Kamchi, N, El Khaldi, M, Elleaume, H, Ergenlik, E, Estève, F, Favier, P, Fernandez, M, Gamelin, A, Garaut, J, Garolfi, L, Gauron, P, Gauthier, F, Girault, P, Gonnin, A, Grasset, D, Guerard, E, Guler, H, Haissinski, J, Hazemann, J, Helder, D, Herbeaux, C, Herry, E, Hodeau, J, Horodynski, J, Hubert, N, Iaquaniello, G, Jacquet, P, Jeantet, P, Jehanno, D, Jules, E, Kapoujyan, G, Kubytskyi, V, Labat, M, Labaye, F, Lacipière, J, Lacroix, M, Lahéra, E, Langlet, M, Lebarillec, T, Ledu, J, Le Duc, G, Le Guidec, D, Leluan, B, Lepercq, P, Lestrade, A, Jacquet M., Alexandre P., Alkadi M., Alves M., Amer M., Amoudry L., Auguste D., Babigeon J. L., Balcou P., Baltazar M., Benabderrahmane C., el Fekih R. B., Benoit A., Berteaud P., Biagini M., Blin A., Bobault S., Bonanzingamarco M., Bonenfant J., Bonis J., Bouanani Y., Bouaziz S., Bouvet F., Bravin A., Bruni C., Bruyere C., Bzyl H., Cassinari L., Cassou K., Cayla J. N., Chabaud T., Chaikovska I., Chance S., Chapelle C., Chaumat V., Chiche R., Cobessi A., Cormier E., Cornebise P., Couprie M. E., Cuoq R., Dalifard O., Degallaix J., Delerue N., Del Net W., Diaz A., Dietrich Y., Diop M., Dorkel R., Douillet D., Drebot I., Dugal J. P., Dupraz K., Dupuy E., El Ajjouri M., El Kamchi N., El Khaldi M., Elleaume H., Ergenlik E., Estève F., Favier P., Fernandez M., Gamelin A., Garaut J. F., Garolfi L., Gauron P., Gauthier F., Girault P., Gonnin A., Grasset D., Guerard E., Guler H., Haissinski J., Hazemann J. L., Helder D., Herbeaux C., Herry E., Hodeau J. L., Horodynski J. M., Hubert N., Iaquaniello G., Jacquet P., Jeantet P., Jehanno D., Jules E., Kapoujyan G., Kubytskyi V., Labat M., Labaye F., Lacipière J., Lacroix M., Lahéra E., Langlet M., Lebarillec T., Ledu J. F., Le Duc G., Le Guidec D., Leluan B., Lepercq P., and Lestrade A.

Abstract

With the increase in laser power and finesse of optical cavities over the last decade, laboratory-size Compton sources are very promising. These sources produce X-rays through interactions between relativistic electrons and laser photons and, in term of brightness, fall between large synchrotron facilities and classical laboratory X-ray sources. The ThomX source is the French project in this field. This article first presents a state of the art of high-intensity Compton sources, then the ThomX source is briefly described, and the first results are detailed, in particular the production of the first X-rays, the acquisition of the first spectrum and the first image of the beam. Finally, the next objectives are discussed.

Published
2024

7. 3D Spatial Distribution of Nanoparticles in Mice Brain Metastases by X-ray Phase-Contrast Tomography

Author

Longo, E, Sancey, L, Cedola, A, Barbier, E, Bravin, A, Brun, F, Bukreeva, I, Fratini, M, Massimi, L, Greving, I, Le Duc, G, Tillement, O, De La Rochefoucauld, O, Zeitoun, P, Longo E., Sancey L., Cedola A., Barbier E. L., Bravin A., Brun F., Bukreeva I., Fratini M., Massimi L., Greving I., Le Duc G., Tillement O., De La Rochefoucauld O., Zeitoun P., Longo, E, Sancey, L, Cedola, A, Barbier, E, Bravin, A, Brun, F, Bukreeva, I, Fratini, M, Massimi, L, Greving, I, Le Duc, G, Tillement, O, De La Rochefoucauld, O, Zeitoun, P, Longo E., Sancey L., Cedola A., Barbier E. L., Bravin A., Brun F., Bukreeva I., Fratini M., Massimi L., Greving I., Le Duc G., Tillement O., De La Rochefoucauld O., and Zeitoun P.

Abstract

Characterizing nanoparticles (NPs) distribution in multiple and complex metastases is of fundamental relevance for the development of radiological protocols based on NPs administration. In the literature, there have been advances in monitoring NPs in tissues. However, the lack of 3D information is still an issue. X-ray phase-contrast tomography (XPCT) is a 3D label-free, non-invasive and multi-scale approach allowing imaging anatomical details with high spatial and contrast resolutions. Here an XPCT qualitative study on NPs distribution in a mouse brain model of melanoma metastases injected with gadolinium-based NPs for theranostics is presented. For the first time, XPCT images show the NPs uptake at micrometer resolution over the full brain. Our results revealed a heterogeneous distribution of the NPs inside the melanoma metastases, bridging the gap in spatial resolution between magnetic resonance imaging and histology. Our findings demonstrated that XPCT is a reliable technique for NPs detection and can be considered as an emerging method for the study of NPs distribution in organs.

Published
2021

8. Genetic and Molecular Analysis of Nod Factor Signalling in Medicago truncatula

Author

Debellé, F., Bres, C., Lévy, J., Ben Amor, B., Arrighi, JF., Maillet, F., Ane, JM., Rosenberg, C., Dénarié, J., Shaw, S., Oldroyd, G., Long, S., Penmetsa, R., Cook, D., Geurts, R., Bisseling, T., Duc, G., Gough, C., Wang, Yi-Ping, editor, Lin, Min, editor, Tian, Zhe-Xian, editor, Elmerich, Claudine, editor, and Newton, William E., editor

Published
2005
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9. Trimodal low-dose X-ray tomography

Author

Zanette, I., Bech, M., Rack, A., Le Duc, G., Tafforeau, P., David, C., Mohr, J., Pfeiffer, F., and Weitkamp, T.

Published
2012

12. How to Evaluate Slow Oxygenation Changes to Estimate Absolute Cerebral Haemoglobin Concentration by Near Infrared Spectrophotometry in Neonates

Author

Wolf, M., Bucher, H.-U., Dietz, V., Keel, M., von Siebenthal, K., Duc, G., Nemoto, Edwin M., editor, LaManna, Joseph C., editor, Cooper, Christopher, editor, Delpy, David, editor, Groebe, Karlfried, editor, Hunt, Thomas K., editor, Keipert, Peter, editor, Mayevsky, Avrahim, editor, Pittman, Roland N., editor, Rumsey, William L., editor, Vaupel, Peter, editor, and Wilson, David F., editor

Published
1997
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22. Non-conventional Ultra-High Dose Rate (FLASH) Microbeam Radiotherapy Provides Superior Normal Tissue Sparing in Rat Lung Compared to Non-conventional Ultra-High Dose Rate (FLASH) Radiotherapy

Author

Wright, M, Romanelli, P, Bravin, A, Le Duc, G, Brauer-Krisch, E, Requardt, H, Bartzsch, S, Hlushchuk, R, Laissue, J, Djonov, V, Wright, Michael D, Romanelli, Pantaleo, Bravin, Alberto, Le Duc, Geraldine, Brauer-Krisch, Elke, Requardt, Herwig, Bartzsch, Stefan, Hlushchuk, Ruslan, Laissue, Jean-Albert, Djonov, Valentin, Wright, M, Romanelli, P, Bravin, A, Le Duc, G, Brauer-Krisch, E, Requardt, H, Bartzsch, S, Hlushchuk, R, Laissue, J, Djonov, V, Wright, Michael D, Romanelli, Pantaleo, Bravin, Alberto, Le Duc, Geraldine, Brauer-Krisch, Elke, Requardt, Herwig, Bartzsch, Stefan, Hlushchuk, Ruslan, Laissue, Jean-Albert, and Djonov, Valentin

Abstract

Conventional radiotherapy is a widely used non-invasive form of treatment for many types of cancer. However, due to a low threshold in the lung for radiation-induced normal tissue damage, it is of less utility in treating lung cancer. For this reason, surgery is the preferred treatment for lung cancer, which has the detriment of being highly invasive. Non-conventional ultra-high dose rate (FLASH) radiotherapy is currently of great interest in the radiotherapy community due to demonstrations of reduced normal tissue toxicity in lung and other anatomy. This study investigates the effects of FLASH microbeam radiotherapy, which in addition to ultra-high dose rate incorporates a spatial segmentation of the radiation field, on the normal lung tissue of rats. With a focus on fibrotic damage, this work demonstrates that FLASH microbeam radiotherapy provides an order of magnitude increase in normal tissue radio-resistance compared to FLASH radiotherapy. This result suggests FLASH microbeam radiotherapy holds promise for much improved noninvasive control of lung cancer.

Published
2021

29. Micro-imaging of Brain Cancer Radiation Therapy Using Phase-contrast Computed Tomography

Author

Barbone, G, Bravin, A, Romanelli, P, Mittone, A, Bucci, D, Gaabeta, T, Le Duc, G, Auweter, S, Reiser, M, Kraiger, M, Hrabe de Angelis, M, Battaglia, G, Coan, P, Barbone G. E., Bravin A., Romanelli P., Mittone A., Bucci D., Gaabeta T., Le Duc G., Auweter S., Reiser M. F., Kraiger M. J., Hrabe de Angelis M., Battaglia G., Coan P., Barbone, G, Bravin, A, Romanelli, P, Mittone, A, Bucci, D, Gaabeta, T, Le Duc, G, Auweter, S, Reiser, M, Kraiger, M, Hrabe de Angelis, M, Battaglia, G, Coan, P, Barbone G. E., Bravin A., Romanelli P., Mittone A., Bucci D., Gaabeta T., Le Duc G., Auweter S., Reiser M. F., Kraiger M. J., Hrabe de Angelis M., Battaglia G., and Coan P.

Abstract

Purpose: Experimental neuroimaging provides a wide range of methods for the visualization of brain anatomic morphology down to subcellular detail. Still, each technique-specific detection mechanism presents compromises among the achievable field-of-view size, spatial resolution, and nervous tissue sensitivity, leading to partial sample coverage, unresolved morphologic structures, or sparse labeling of neuronal populations and often also to obligatory sample dissection or other sample invasive manipulations. X-ray phase-contrast imaging computed tomography (PCI-CT) is an experimental imaging method that simultaneously provides micrometric spatial resolution, high soft-tissue sensitivity, and ex vivo full organ rodent brain coverage without any need for sample dissection, staining or labeling, or contrast agent injection. In the present study, we explored the benefits and limitations of PCI-CT use for in vitro imaging of normal and cancerous brain neuromorphology after in vivo treatment with synchrotron-generated x-ray microbeam radiation therapy (MRT), a spatially fractionated experimental high-dose radiosurgery. The goals were visualization of the MRT effects on nervous tissue and a qualitative comparison of the results to the histologic and high-field magnetic resonance imaging findings. Methods and Materials: MRT was administered in vivo to the brain of both healthy and cancer-bearing rats. At 45 days after treatment, the brain was dissected out and imaged ex vivo using propagation-based PCI-CT. Results: PCI-CT visualizes the brain anatomy and microvasculature in 3 dimensions and distinguishes cancerous tissue morphology, necrosis, and intratumor accumulation of iron and calcium deposits. Moreover, PCI-CT detects the effects of MRT throughout the treatment target areas (eg, the formation of micrometer-thick radiation-induced tissue ablation). The observed neurostructures were confirmed by histologic and immunohistochemistry examination and related to the micro-mag

Published
2018

37. OC-0561: Nano-Rad first in man study: AGuIX nanoparticles as radiosensitizing agent for radiotherapy

Author

Verry, C., primary, Dufort, S., additional, Le Duc, G., additional, Mendoza, C., additional, Lux, F., additional, Arnaud, J., additional, Sancey, L., additional, Adolle, A., additional, Gavard, M., additional, Jover, F., additional, Grand, S., additional, Iriart, C., additional, Villa, J., additional, Balosso, J., additional, and Tillement, O., additional

Published
2020
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39. Synchrotron-generated microbeams induce hippocampal transections in rats

Author

Fardone, E., Pouyatos, B., Bräuer-Krisch, E., Bartzsch, S., Mathieu, H., Requardt, H., Bucci, D., Barbone, G., Coan, P., Battaglia, G., Le Duc, G., Bravin, A., Romanelli, P., European Synchrotron Radiation Facility (ESRF), Neuro-imagerie fonctionnelle et métabolique (ANTE-INSERM U836, équipe 5), Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Radiation Oncology [Munich], Ludwig-Maximilians-Universität München (LMU), Istituto Neurologico Mediterraneo (NEUROMED I.R.C.C.S.), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome]-Università degli studi di Napoli Federico II, Centro Diagnostico Italiano (CDI), Fardone, E, Pouyatos, B, Brauer_krisch, E, Bartzsch, S, Mathieu, H, Requardt, H, Bucci, D, Barbone, G, Coan, P, Battaglia, G, Le Duc, G, Bravin, A, and Romanelli, P

Subjects
Male, STEREOTACTIC RADIOSURGERY, SURGERY, [SDV]Life Sciences [q-bio], lcsh:Medicine, FIS/07 - FISICA APPLICATA (A BENI CULTURALI, AMBIENTALI, BIOLOGIA E MEDICINA), Radiosurgery, Hippocampus, Article, Histones, RADIATION-THERAPY MRT, Animals, Rats, Wistar, lcsh:Science, EPILEPSY, lcsh:R, Phosphoproteins, equipment and supplies, Rats, MODEL, FRELON CAMERA, SURGICAL-TREATMENT, lcsh:Q, MRT, transections, X-rays, microsurgery, Synchrotrons, MONTE-CARLO SIMULATIONS
Abstract

International audience; Synchrotron-generated microplanar beams (microbeams) provide the most stereo-selective irradiation modality known today. This novel irradiation modality has been shown to control seizures originating from eloquent cortex causing no neurological deficit in experimental animals. To test the hypothesis that application of microbeams in the hippocampus, the most common source of refractory seizures, is safe and does not induce severe side effects, we used microbeams to induce transections to the hippocampus of healthy rats. An array of parallel microbeams carrying an incident dose of 600 Gy was delivered to the rat hippocampus. Immunohistochemistry of phosphorylated gamma-H2AX showed cell death along the microbeam irradiation paths in rats 48 hours after irradiation. No evident behavioral or neurological deficits were observed during the 3-month period of observation. MR imaging showed no signs of radio-induced edema or radionecrosis 3 months after irradiation. Histological analysis showed a very well preserved hippocampal cytoarchitecture and confirmed the presence of clear-cut microscopic transections across the hippocampus. These data support the use of synchrotron-generated microbeams as a novel tool to slice the hippocampus of living rats in a minimally invasive way, providing (i) a novel experimental model to study hippocampal function and (ii) a new treatment tool for patients affected by refractory epilepsy induced by mesial temporal sclerosis.

Published
2018

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