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20. Allergen sensitization patterns in the French COBRAPed cohort

Author

Lejeune, S, Bouazza, N, Roland Nicaise, P, Jolaine, V, Roditis, L, Marguet, C, Houdoin, V, Berger, P, Fayon, M, Dubus, J, Pin, I, Reix, P, Pellan, M, Brouard, J, Chiron, R, Giovannini-Chami, L, de Blic, J, Deschildre, A, Lezmi, G, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Pneumologie et allergologie pédiatriques [CHU Jeanne de Flandre, Lille], Hôpital Jeanne de Flandre [Lille], Service de pneumologie, allergologie, mucoviscidose pédiatrique [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Aquitaine’s Care and Research organisation for inflammatory and Immune-Mediated diseases [CHU Bordeaux] (FHU ACRONIM), CHU Bordeaux [Bordeaux], Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU), Hôpital de la Timone [CHU - APHM] (TIMONE), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Département de Pédiatrie - CHRU de Grenoble, CHU Grenoble, Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Burgundy School of Business (BSB) - Ecole Supérieure de Commerce de Dijon Bourgogne (ESC) (BSB), Centres de Ressources et de Compétences de la Mucoviscidose [Montpellier] (CRCM [Montpellier]), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Arnaud de Villeneuve-Service des Maladies Respiratoires, Hôpitaux Pédiatriques de Nice Lenval (CHU-Lenval), Centre Hospitalier Universitaire de Nice (CHU Nice), Université de Nice Sophia-Antipolis (UNSA), Service de Pneumologie Allergologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Service de Pneumologie et d'Allergologie Pédiatriques

Subjects
[SDV]Life Sciences [q-bio]
Abstract

International audience

Published
2022

22. Allergen sensitization patterns in the French COBRAPed cohort

Author

Lejeune, S, primary, Bouazza, N, additional, Roland Nicaise, P, additional, Jolaine, V, additional, Roditis, L, additional, Marguet, C, additional, Houdoin, V, additional, Berger, P, additional, Fayon, M, additional, Dubus, J, additional, Pin, I, additional, Reix, P, additional, Pellan, M, additional, Brouard, J, additional, Chiron, R, additional, Giovannini-Chami, L, additional, De Blic, J, additional, Deschildre, A, additional, and Lezmi, G, additional

Published
2022
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24. Recommandations sur l’utilisation des nouveaux outils diagnostiques étiologiques des infections respiratoires basses de l’enfant de plus de trois mois

Author

Dubus, J.-C., Delacourt, C., Marguet, C., Houdouin, V., Pouessel, G., Angoulvant, F., Brouard, J., Derelle, J., Fayon, M., Ferroni, A., Gangneux, J.-P., Hau, I., Le Bourgeois, M., Lorrot, M., Menotti, J., Nathan, N., Vabret, A., Wallet, F., Bonacorsi, S., Cohen, R., de Blic, J., Deschildre, A., Gandemer, V., Pin, I., Labbe, A., Le Roux, P., Martinot, A., and Rammaert, B.

Published
2014
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33. Sputum immunoglobulin E: towards a new world ?

Author

Michel, M., Sereme, Y., Gonzalez, C., Sahli, W., Pinchemel, S., Bermudez, J., Coiffard, B., Dubus, J., Reynaud-Gaubert, M., Vitte, Joana, Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Aix Marseille Université (AMU), Hôpital Nord [CHU - APHM], Hôpital de la Timone [CHU - APHM] (TIMONE), Institut Desbrest de santé publique (IDESP), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)

Subjects
[SDV]Life Sciences [q-bio], [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Background: The role of immunoglobulin E (IgE) –dependent mechanisms leading to exacerbations and respiratory function worsening in cystic fibrosis patients is well acknowledged but not easy to characterize. We hypothesize that the availability of new tools such as allergen microarrays may contribute to a better understanding of disease-related local lung IgE responses.Method: We developed a three-step protocol to characterize specific IgE (sIgE) from cystic fibrosis patients’ sputum. First, sputum was fluxed and filtered before an overnight freeze-drying step. After re-suspending, we performed an allergen microarray with more than 300 allergenic extracts and components.Results: The protocol was applied to sputum samples from 22 cystic fibrosis patients, including 5 lung transplanted patients. The age was similar between non-transplanted and lung transplanted patients, with a median of 29 (IQR 17–72) and 39 (18–53) years, respectively. Non-transplanted patients had a higher overall IgE response against environmental allergens, especially animal dander allergens (p = 0.0004) and house dust mites (P = 0.03). IgE responses against molds did not differ between groups. No correlation was found between each patient’s IgE response to fungal extracts and components and fungal colonization. However, presence of sputum sIgE against fungal allergens, notably Cladosporium herbarum, was correlated with ongoing exacerbation.Conclusion: We have developed a technically simple protocol allowing non-invasive investigation of an extended analysis of local humoral immunity in cystic fibrosis patients. Exploration of sputum through allergen microarray may guide the identification of culprit agents leading to exacerbations and contribute to better management of cystic fibrosis patients.

Published
2021

36. Childhood asthma outcomes during the COVID-19 pandemic:findings from the PeARL multinational cohort

Author

Papadopoulos, N. G. (Nikolaos G.), Mathioudakis, A. G. (Alexander G.), Custovic, A. (Adnan), Deschildre, A. (Antoine), Phipatanakul, W. (Wanda), Wong, G. (Gary), Xepapadaki, P. (Paraskevi), Abou-Taam, R. (Rola), Agache, I. (Ioana), Castro-Rodriguez, J. A. (Jose A.), Chen, Z. (Zhimin), Cros, P. (Pierrick), Dubus, J.-C. (Jean-Christophe), El-Sayed, Z. A. (Zeinab Awad), El-Owaidy, R. (Rasha), Feleszko, W. (Wojciech), Fierro, V. (Vincenzo), Fiocchi, A. (Alessandro), Garcia-Marcos, L. (Luis), Goh, A. (Anne), Hossny, E. M. (Elham M.), Huerta Villalobos, Y. R. (Yunuen R.), Jartti, T. (Tuomas), Le Roux, P. (Pascal), Levina, J. (Julia), Lopez Garcia, A. I. (Aida Ines), Ramos, A. M. (Angel Mazon), Morais-Almeida, M. (Mario), Murray, C. (Clare), Nagaraju, K. (Karthik), Nagaraju, M. K. (Major K.), Navarrete Rodriguez, E. M. (Elsy Maureen), Namazova-Baranova, L. (Leyla), Nieto Garcia, A. (Antonio), Pozo Beltran, C. F. (Cesar Fireth), Ratchataswan, T. (Thanaporn), Rivero Yeverino, D. (Daniela), Rodriguez Zagal, E. (Erendira), Schweitzer, C. E. (Cyril E.), Tulkki, M. (Marleena), Wasilczuk, K. (Katarzyna), and Xu, D. (Dan)

Subjects
immune system diseases, childhood asthma, coronavirus, COVID-19, respiratory tract diseases
Abstract

Background: The interplay between COVID-19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes. Methods: The PeARL multinational cohort included 1,054 children with asthma and 505 non-asthmatic children aged between 4 and 18 years from 25 pediatric departments, from 15 countries globally. We compared the frequency of acute respiratory and febrile presentations during the first wave of the COVID-19 pandemic between groups and with data available from the previous year. In children with asthma, we also compared current and historical disease control. Results: During the pandemic, children with asthma experienced fewer upper respiratory tract infections, episodes of pyrexia, emergency visits, hospital admissions, asthma attacks, and hospitalizations due to asthma, in comparison with the preceding year. Sixty-six percent of asthmatic children had improved asthma control while in 33% the improvement exceeded the minimal clinically important difference. Pre-bronchodilatation FEV₁ and peak expiratory flow rate were improved during the pandemic. When compared to non-asthmatic controls, children with asthma were not at increased risk of LRTIs, episodes of pyrexia, emergency visits, or hospitalizations during the pandemic. However, an increased risk of URTIs emerged. Conclusions: Childhood asthma outcomes, including control, were improved during the first wave of the COVID-19 pandemic, probably because of reduced exposure to asthma triggers and increased treatment adherence. The decreased frequency of acute episodes does not support the notion that childhood asthma may be a risk factor for COVID-19. Furthermore, the potential for improving childhood asthma outcomes through environmental control becomes apparent.

Published
2021

37. Childhood asthma outcomes during the COVID-19 pandemic: Findings from the PeARL multi-national cohort

Author

Papadopoulos, N.G. Mathioudakis, A.G. Custovic, A. Deschildre, A. Phipatanakul, W. Wong, G. Xepapadaki, P. Abou-Taam, R. Agache, I. Castro-Rodriguez, J.A. Chen, Z. Cros, P. Dubus, J.-C. El-Sayed, Z.A. El-Owaidy, R. Feleszko, W. Fierro, V. Fiocchi, A. Garcia-Marcos, L. Goh, A. Hossny, E.M. Huerta Villalobos, Y.R. Jartti, T. Le Roux, P. Levina, J. López García, A.I. Ramos, Á.M. Morais-Almeida, M. Murray, C. Nagaraju, K. Nagaraju, M.K. Navarrete Rodriguez, E.M. Namazova-Baranova, L. Nieto Garcia, A. Pozo Beltrán, C.F. Ratchataswan, T. Rivero Yeverino, D. Rodríguez Zagal, E. Schweitzer, C.E. Tulkki, M. Wasilczuk, K. Xu, D. Alekseeva, A. Almeida, B. Andre, M. Arimova, P. Blonde, A. Cunningham, A. Da Mota, S. Efendieva, K. Kalugina, V. Kiefer, S. Klein, A. López, C.G.C. López, J.J.R. Moratellti, C. Fuentes Pérez, M. Simermann, M. Tapia, J.S.P. Tatopoulos, A. Vishneva, E. Volkov, Κ. Bacharier, L. Bonini, M. Craig, T. Diamant, Z. Ducharme, F.M. Gern, J.E. Grigg, J. Hamelmann, E.H. Hedlin, G. Jartti, T. Kalayci, O. Kaplan, A. Konradsen, J. Kuna, P. Lau, S. Le Souef, P. Lemanske, R.F. Makela, M.J. Matricardi, P.M. Gómez, R.-M. Miligkos, M. Pitrez, P.M.C. Price, D. Pohunek, P. Roberts, G.C. Sheikh, A. Tsiligianni, I. Turner, S. Valiulis, A. Winders, T. Yusuf, O.M. Zar, H. PeARL collaborators, on behalf of the PeARL Think Tank

Subjects
respiratory tract diseases
Abstract

Background: The interplay between COVID-19 pandemic and asthma in children is still unclear. We evaluated the impact of COVID-19 pandemic on childhood asthma outcomes. Methods: The PeARL multinational cohort included 1,054 children with asthma and 505 non-asthmatic children aged between 4 and 18 years from 25 pediatric departments, from 15 countries globally. We compared the frequency of acute respiratory and febrile presentations during the first wave of the COVID-19 pandemic between groups and with data available from the previous year. In children with asthma, we also compared current and historical disease control. Results: During the pandemic, children with asthma experienced fewer upper respiratory tract infections, episodes of pyrexia, emergency visits, hospital admissions, asthma attacks, and hospitalizations due to asthma, in comparison with the preceding year. Sixty-six percent of asthmatic children had improved asthma control while in 33% the improvement exceeded the minimal clinically important difference. Pre-bronchodilatation FEV1 and peak expiratory flow rate were improved during the pandemic. When compared to non-asthmatic controls, children with asthma were not at increased risk of LRTIs, episodes of pyrexia, emergency visits, or hospitalizations during the pandemic. However, an increased risk of URTIs emerged. Conclusion: Childhood asthma outcomes, including control, were improved during the first wave of the COVID-19 pandemic, probably because of reduced exposure to asthma triggers and increased treatment adherence. The decreased frequency of acute episodes does not support the notion that childhood asthma may be a risk factor for COVID-19. Furthermore, the potential for improving childhood asthma outcomes through environmental control becomes apparent. © 2021 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.

Published
2021

45. Impact of COVID-19 on Pediatric Asthma: Practice Adjustments and Disease Burden

Author

Papadopoulos, N.G. Custovic, A. Deschildre, A. Mathioudakis, A.G. Phipatanakul, W. Wong, G. Xepapadaki, P. Agache, I. Bacharier, L. Bonini, M. Castro-Rodriguez, J.A. Chen, Z. Craig, T. Ducharme, F.M. El-Sayed, Z.A. Feleszko, W. Fiocchi, A. Garcia-Marcos, L. Gern, J.E. Goh, A. Gómez, R.M. Hamelmann, E.H. Hedlin, G. Hossny, E.M. Jartti, T. Kalayci, O. Kaplan, A. Konradsen, J. Kuna, P. Lau, S. Le Souef, P. Lemanske, R.F. Mäkelä, M.J. Morais-Almeida, M. Murray, C. Nagaraju, K. Namazova-Baranova, L. Garcia, A.N. Yusuf, O.M. Pitrez, P.M.C. Pohunek, P. Pozo Beltrán, C.F. Roberts, G.C. Valiulis, A. Zar, H.J. Taam, R.A. Azuara, H. Brouard, J. Cros, P. De Lira, C. Dubus, J.-C. Dunder, T. Efendieva, K. Egron, C. Emeryk, A. Huerta Villalobos, Y.R. Karen, N. Le Roux, P. Levina, J. Medley, M. Najaraju, M. Yeverino, D.R. Ruotsalainen, M. Szefler, S. Schweitzer, C. Benhumea, B.V. Villarreal, R. Weiss, L. Zawadzka-Krajewska, A.

Abstract

Background: It is unclear whether asthma may affect susceptibility or severity of coronavirus disease 2019 (COVID-19) in children and how pediatric asthma services worldwide have responded to the pandemic. Objective: To describe the impact of the COVID-19 pandemic on pediatric asthma services and on disease burden in their patients. Methods: An online survey was sent to members of the Pediatric Asthma in Real Life think tank and the World Allergy Organization Pediatric Asthma Committee. It included questions on service provision, disease burden, and the clinical course of confirmed cases of COVID-19 infection among children with asthma. Results: Ninety-one respondents, caring for an estimated population of more than 133,000 children with asthma, completed the survey. COVID-19 significantly impacted pediatric asthma services: 39% ceased physical appointments, 47% stopped accepting new patients, and 75% limited patients' visits. Consultations were almost halved to a median of 20 (interquartile range, 10-25) patients per week. Virtual clinics and helplines were launched in most centers. Better than expected disease control was reported in 20% (10%-40%) of patients, whereas control was negatively affected in only 10% (7.5%-12.5%). Adherence also appeared to increase. Only 15 confirmed cases of COVID-19 were reported among the population; the estimated incidence is not apparently different from the reports of general pediatric cohorts. Conclusions: Children with asthma do not appear to be disproportionately affected by COVID-19. Outcomes may even have improved, possibly through increased adherence and/or reduced exposures. Clinical services have rapidly responded to the pandemic by limiting and replacing physical appointments with virtual encounters. © 2020 American Academy of Allergy, Asthma & Immunology

Published
2020

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