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3. Cannabis Use and Reduced Risk of Insulin Resistance in HIV-HCV Infected Patients: A Longitudinal Analysis (ANRS CO13 HEPAVIH)

Author

Carrieri, Maria Patrizia, Serfaty, Lawrence, Vilotitch, Antoine, Poizot-Martin, Isabelle, Loko, Marc-Arthur, Lions, Caroline, Salmon-Ceron, Dominique, Spire, Bruno, Dabis, François, Salmon, D, Dabis, F, Winnock, M, Sogni, P, Benhamou, Y, Trimoulet, P, Izopet, J, Paradis, V, Spire, B, Carrieri, P, Katlama, C, Pialoux, G, Valantin, M A, Bonnard, P, Rosenthal, E, Garipuy, D, Bouchaud, O, Gervais, A, Lascoux-Combe, C, Goujard, C, Lacombe, K, Duvivier, C, Vittecoq, D, Neau, D, Morlat, P, Banisadr, F, Meyer, L, Boufassa, F, Dominguez, S, Autran, B, Roque, a M, Solas, C, Fontaine, H, Serfaty, L, Chêne, G, Costagliola, D, Zucman, D, Simon, A, Billaud, E, Miailhes, P, Devoto, J Polo, Couffin-Cadiergues, S, Mehawej, H, Makhlouf, Z, Dubost, G, Tessier, F, Gibault, L, Beuvon, F, Chambon, E, Lazure, T, Krivine, A, Charlotte, F, Fourati, S, Cacoub, P, Nafissa, S, Zaegel, O, Ménard, A, Geneau, P, Tamalet, C, Bani-Sadr, F, Slama, L, Lyavanc, T, Callard, P, Bendjaballah, F, Le-Pendeven, C, Marchou, B, Alric, Laurent, Barange, K, Metivier, S, Fooladi, A, Selves, J, Nicot, F, Durant, J, Haudebourg, J, Saint-Paul, M C, Ziol, M, Baazia, Y, Uzan, M, Bicart-See, A, Ferro-Collados, M J, Yéni, P, Adle-Biassette, H, Molina, J M, Combe, C Lascoux, Bertheau, P, Duclos, J, Palmer, P, Girard, P M, Campa, P, Wendum, D, Cervera, P, Adam, J, Harchi, N, Delfraissy, J F, Quertainmont, Y, Pallier, C, Lortholary, O, Shoai-Tehrani, M, Lacaze-Buzy, L, Caldato, S, Bioulac-Sage, P, Reigadas, S, Majerholc, C, Guitard, F, Boue, F, Kansau, I, Chambrin, V, Pignon, C, Berroukeche, L, Fior, R, Martinez, V, Deback, C, Lévy, Y, Lelièvre, J D, Lascaux, a S, Melica, G, Raffi, F, Alavena, C, Rodallec, A, Peyramond, D, Chidiac, C, Ader, F, Biron, F, Boibieux, A, Cotte, L, Ferry, T, Perpoint, T, Koffi, J, Zoulim, F, Bailly, F, Lack, P, Radenne, S, Amiri, M, Beniken, D, Ritleng, a S, Azar, M, Honoré, P, Breau, S, Joulie, A, Mole, M, Bolliot, C, Chouraqui, F, Touam, F, André, F, Ouabdesselam, N, Partouche, C, Alexandre, G, Ganon, A, Champetier, A, Hue, H, Brosseau, D, Brochier, C, Thoirain, V, Rannou, M, Bornarel, D, Gillet, S, Delaune, J, Pambrun, E, Dequae-Merchadou, L, Frosch, A, Maradan, G, Cheminat, O, Marcellin, F, Mora, M, Protopopescu, C, Aix Marseille Université (AMU), Pathologies biliaires, fibrose et cancer du foie [CRSA], Centre de Recherche Saint-Antoine (CRSA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U912 INSERM - Aix Marseille Univ - IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidemiologie-Biostatistique [Bordeaux], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bordeaux Ségalen [Bordeaux 2], AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Pharmacochimie et Biologie pour le Développement (PHARMA-DEV), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Pathologies biliaires, fibrose et cancer du foie [CHU Saint-Antoine], Centre de Recherche Saint-Antoine (CR Saint-Antoine), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Institut de Recherche pour le Développement (IRD)-Institut de Chimie de Toulouse (ICT-FR 2599), Institut National Polytechnique (Toulouse) (Toulouse INP), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)-Institut National Polytechnique (Toulouse) (Toulouse INP), and Université Fédérale Toulouse Midi-Pyrénées-Institut de Chimie du CNRS (INC)

Subjects
cannabis, Microbiology (medical), Adult, Male, medicine.medical_specialty, Marijuana Abuse, [SDV]Life Sciences [q-bio], Population, HIV Infections, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Surveys and Questionnaires, cohort study, medicine, Humans, 030212 general & internal medicine, Longitudinal Studies, education, education.field_of_study, biology, business.industry, Confounding, HIV, Odds ratio, Hepatitis C, Chronic, Middle Aged, biology.organism_classification, Confidence interval, 3. Good health, Infectious Diseases, Endocrinology, HCV, Cohort, Homeostatic model assessment, 030211 gastroenterology & hepatology, Female, Cannabis, France, Insulin Resistance, business, Cohort study
Abstract

International audience; Diabetes and insulin resistance (IR) is common in human immunodeficiency virus-hepatitis C virus (HIV-HCV)-coinfected patients, a population also concerned with elevated cannabis use. Cannabis has been associated with reduced IR risk in some population-based surveys. We determined whether cannabis use was consistently associated with reduced IR risk in HEPAVIH, a French nationwide cohort of HIV-HCV-coinfected patients.Methods: HEPAVIH medical and sociobehavioral data were collected (using annual self-administered questionnaires). We used 60 months of follow-up data for patients with at least 1 medical visit where IR (using homeostatic model assessment of insulin resistance [HOMA-IR]) and cannabis use were assessed. A mixed logistic regression model was used to evaluate the association between IR risk (HOMA-IR > 2.77) and cannabis use (occasional, regular, daily).Results: Among the 703 patients included in the study (1287 visits), 323 (46%) had HOMA-IR > 2.77 for at least 1 follow-up visit and 319 (45%) reported cannabis use in the 6 months before the first available visit. Cannabis users (irrespective of frequency) were less likely to have HOMA-IR > 2.77 (odds ratio [95% confidence interval], 0.4 [.2-.5]) after adjustment for known correlates/confounders. Two sensitivity analyses with HOMA-IR values as a continuous variable and a cutoff value of 3.8 confirmed the association between reduced IR risk and cannabis use.Conclusions: Cannabis use is associated with a lower IR risk in HIV-HCV-coinfected patients. The benefits of cannabis-based pharmacotherapies for patients concerned with increased risk of IR and diabetes need to be evaluated in clinical research and practice.

Published
2014

4. Biological Effects of Millimeter-Wave Irradiation on Mice--Preliminary Results

Author

Bellossi, A., Dubost, G., Moulinoux, J. P., Himdi, M., Ruelloux, M., and Rocher, C.

Subjects
Microwaves -- Physiological aspects, Electromagnetic radiation -- Physiological aspects, Business, Computers, Electronics, Electronics and electrical industries
Abstract

Millimeter waves at 60 GHz are suitable for discreet radio contact in a restricted area, especially for indoor high-rate communications. Such wave exposures have not been reported. That is the reason why a study of possible biological effects upon living beings was required. An experimental irradiation device was calibrated and used to irradiate mice. Specific absorption rate and internal fields have been computed for a mouse irradiated at 60 GHz. The measured power flux in free space at the irradiation area is close to 0.5 mW/[cm.sup.2], this probably produces some subtle biological effects. To look for possible biological effects, we exposed DBA2 mice grafted either with L1210 cells or with Lewis tumor cells and healthy Swiss mice. There were four obvious observations: there is an individual sensitiveness to 60 GHz waves; the survival of mice grafted with L1210 cells could be increased; the growth of Lewis tumor was enhanced; and the activity of Swiss mice was increased. In any way, those effects have to be taken into account, and we suggest prudence before using a 60-GHz wave for indoor communications. Index Terms--Biological effects of electromagnetic radiations.

Published
2000

34. Livres reçus

Author

Dubost, G., primary, Cohen, G., additional, Wolfmann, J., additional, Perez, J. C., additional, Farcy, R., additional, Davalo, E., additional, Naim, P., additional, Hawkes, P. W., additional, Yahouedeou, J., additional, Laurini, R., additional, Milleret-Raffort, F., additional, Lonchamp, J., additional, Delahaye, J. P., additional, Nachszunow, G., additional, Pasleau, S., additional, Iris, E., additional, Aubes, M, additional, Chenerie, I., additional, Combes, P. F, additional, Graffeuel, J., additional, Laprie, J. C, additional, Courtois, B., additional, Gaudel, M. C, additional, and Powell, D., additional

Published
1990
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