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137 results on '"Dubois, Fatéméh"'

2. VEGFR2 and CD34 expression associated with longer survival in patients with pleural mesothelioma in the IFCT-GFPC-0701 MAPS phase 3 trial

Author

Levallet, Guénaëlle, Dubois, Fatéméh, Elie, Nicolas, Creveuil, Christian, Brosseau, Solenn, Danel, Claire, Scherpereel, Arnaud, Lantuejoul, Sylvie, Mazières, Julien, Greillier, Laurent, Audigier-Valette, Clarisse, Bergot, Emmanuel, Moro-Sibilot, Denis, Molinier, Olivier, Léna, Hervé, Monnet, Isabelle, Morin, Franck, Gounant, Valérie, and Zalcman, Gérard

Published
2023
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7. Supplementary Table 1 from High TUBB3 Expression, an Independent Prognostic Marker in Patients with Early Non–Small Cell Lung Cancer Treated by Preoperative Chemotherapy, Is Regulated by K-Ras Signaling Pathway

Author

Levallet, Guénaëlle, primary, Bergot, Emmanuel, primary, Antoine, Martine, primary, Creveuil, Christian, primary, Santos, Adriana O., primary, Beau-Faller, Michelle, primary, de Fraipont, Florence, primary, Brambilla, Elisabeth, primary, Levallet, Jérôme, primary, Morin, Franck, primary, Westeel, Virginie, primary, Wislez, Marie, primary, Quoix, Elisabeth, primary, Debieuvre, Didier, primary, Dubois, Fatéméh, primary, Rouquette, Isabelle, primary, Pujol, Jean-Louis, primary, Moro-Sibilot, Denis, primary, Camonis, Jacques, primary, and Zalcman, Gérard, primary

Published
2023
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8. Supplementary Figure 2 from High TUBB3 Expression, an Independent Prognostic Marker in Patients with Early Non–Small Cell Lung Cancer Treated by Preoperative Chemotherapy, Is Regulated by K-Ras Signaling Pathway

Author

Levallet, Guénaëlle, primary, Bergot, Emmanuel, primary, Antoine, Martine, primary, Creveuil, Christian, primary, Santos, Adriana O., primary, Beau-Faller, Michelle, primary, de Fraipont, Florence, primary, Brambilla, Elisabeth, primary, Levallet, Jérôme, primary, Morin, Franck, primary, Westeel, Virginie, primary, Wislez, Marie, primary, Quoix, Elisabeth, primary, Debieuvre, Didier, primary, Dubois, Fatéméh, primary, Rouquette, Isabelle, primary, Pujol, Jean-Louis, primary, Moro-Sibilot, Denis, primary, Camonis, Jacques, primary, and Zalcman, Gérard, primary

Published
2023
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9. Supplementary Figure 5 from High TUBB3 Expression, an Independent Prognostic Marker in Patients with Early Non–Small Cell Lung Cancer Treated by Preoperative Chemotherapy, Is Regulated by K-Ras Signaling Pathway

Author

Levallet, Guénaëlle, primary, Bergot, Emmanuel, primary, Antoine, Martine, primary, Creveuil, Christian, primary, Santos, Adriana O., primary, Beau-Faller, Michelle, primary, de Fraipont, Florence, primary, Brambilla, Elisabeth, primary, Levallet, Jérôme, primary, Morin, Franck, primary, Westeel, Virginie, primary, Wislez, Marie, primary, Quoix, Elisabeth, primary, Debieuvre, Didier, primary, Dubois, Fatéméh, primary, Rouquette, Isabelle, primary, Pujol, Jean-Louis, primary, Moro-Sibilot, Denis, primary, Camonis, Jacques, primary, and Zalcman, Gérard, primary

Published
2023
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10. Supplementary Figure 3 from High TUBB3 Expression, an Independent Prognostic Marker in Patients with Early Non–Small Cell Lung Cancer Treated by Preoperative Chemotherapy, Is Regulated by K-Ras Signaling Pathway

Author

Levallet, Guénaëlle, primary, Bergot, Emmanuel, primary, Antoine, Martine, primary, Creveuil, Christian, primary, Santos, Adriana O., primary, Beau-Faller, Michelle, primary, de Fraipont, Florence, primary, Brambilla, Elisabeth, primary, Levallet, Jérôme, primary, Morin, Franck, primary, Westeel, Virginie, primary, Wislez, Marie, primary, Quoix, Elisabeth, primary, Debieuvre, Didier, primary, Dubois, Fatéméh, primary, Rouquette, Isabelle, primary, Pujol, Jean-Louis, primary, Moro-Sibilot, Denis, primary, Camonis, Jacques, primary, and Zalcman, Gérard, primary

Published
2023
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11. Supplementary Figure Legends 1-5 from High TUBB3 Expression, an Independent Prognostic Marker in Patients with Early Non–Small Cell Lung Cancer Treated by Preoperative Chemotherapy, Is Regulated by K-Ras Signaling Pathway

Author

Levallet, Guénaëlle, primary, Bergot, Emmanuel, primary, Antoine, Martine, primary, Creveuil, Christian, primary, Santos, Adriana O., primary, Beau-Faller, Michelle, primary, de Fraipont, Florence, primary, Brambilla, Elisabeth, primary, Levallet, Jérôme, primary, Morin, Franck, primary, Westeel, Virginie, primary, Wislez, Marie, primary, Quoix, Elisabeth, primary, Debieuvre, Didier, primary, Dubois, Fatéméh, primary, Rouquette, Isabelle, primary, Pujol, Jean-Louis, primary, Moro-Sibilot, Denis, primary, Camonis, Jacques, primary, and Zalcman, Gérard, primary

Published
2023
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12. Supplementary Figure 4 from High TUBB3 Expression, an Independent Prognostic Marker in Patients with Early Non–Small Cell Lung Cancer Treated by Preoperative Chemotherapy, Is Regulated by K-Ras Signaling Pathway

Author

Levallet, Guénaëlle, primary, Bergot, Emmanuel, primary, Antoine, Martine, primary, Creveuil, Christian, primary, Santos, Adriana O., primary, Beau-Faller, Michelle, primary, de Fraipont, Florence, primary, Brambilla, Elisabeth, primary, Levallet, Jérôme, primary, Morin, Franck, primary, Westeel, Virginie, primary, Wislez, Marie, primary, Quoix, Elisabeth, primary, Debieuvre, Didier, primary, Dubois, Fatéméh, primary, Rouquette, Isabelle, primary, Pujol, Jean-Louis, primary, Moro-Sibilot, Denis, primary, Camonis, Jacques, primary, and Zalcman, Gérard, primary

Published
2023
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13. Supplementary Figure 1 from High TUBB3 Expression, an Independent Prognostic Marker in Patients with Early Non–Small Cell Lung Cancer Treated by Preoperative Chemotherapy, Is Regulated by K-Ras Signaling Pathway

Author

Levallet, Guénaëlle, primary, Bergot, Emmanuel, primary, Antoine, Martine, primary, Creveuil, Christian, primary, Santos, Adriana O., primary, Beau-Faller, Michelle, primary, de Fraipont, Florence, primary, Brambilla, Elisabeth, primary, Levallet, Jérôme, primary, Morin, Franck, primary, Westeel, Virginie, primary, Wislez, Marie, primary, Quoix, Elisabeth, primary, Debieuvre, Didier, primary, Dubois, Fatéméh, primary, Rouquette, Isabelle, primary, Pujol, Jean-Louis, primary, Moro-Sibilot, Denis, primary, Camonis, Jacques, primary, and Zalcman, Gérard, primary

Published
2023
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14. Figure S6. sh-mediated RASSF1A depletion in HBEC-3 cells. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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15. HBEC-3 2D-migration induced by RASS1A-knockdown from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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16. Figure S1: Scheme of RASSF1 splicing isoforms and localization annealing regions of siRNAs and shRNAs used. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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17. Figure S3: Expression of siRNA-resistant RASSF1A rescues EMT phenotype induced by RASSF1A depletion. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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18. Data from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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19. Table S4 from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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20. Figure S8: RhoA activity is not influenced by RASSF1A depletion whereas constitutive activation of a Rho activity by Narciclasine still impairs RASSF1A-induced invasion. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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21. Figure S4: trans-endothelial invasion, enhanced-migration and growth in soft agar upon RASSF1A depletion in 4 transformed and untransformed epithelial bronchial cell lines. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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22. Figure S7: Time-course YAP cytoplasmic-nuclear shuttling upon RASSF1A depletion. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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23. Figure S2: Depletion of RASSF1A alone or with RASSF1C results in disappearance of tight junctions and decrease of adherens junction, replaced by diffuse adherent junctions. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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24. Figure S5. RASSF1A depletion reduces focal adhesion proteins and adhesion capacities in vitro. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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25. legends of supplemental figures from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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26. Figure S9: Loss of RhoB activity increases YAP nuclear localization. from RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, primary, Calvayrac, Olivier, primary, Soncin, Fabrice, primary, Hoa, Lily, primary, Hergovich, Alexander, primary, Parrini, Maria-Carla, primary, Mazières, Julien, primary, Vaisse-Lesteven, Mélissa, primary, Camonis, Jacques, primary, Levallet, Guénaëlle, primary, and Zalcman, Gérard, primary

Published
2023
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29. A defect of amphiregulin release predicted longer survival independently of YAP expression in patients with pleural mesothelioma in the IFCT ‐0701 MAPS phase 3 trial

Author

Maille, Elodie, Levallet, Jérôme, Dubois, Fatéméh, Antoine, Martine, Danel, Claire, Creveuil, Christian, Mazieres, Julien, Margery, Jacques, Greillier, Laurent, Gounant, Valérie, Moro‐sibilot, Denis, Molinier, Olivier, Léna, Hervé, Monnet, Isabelle, Bergot, Emmanuel, Langlais, Alexandra, Morin, Franck, Sherpereel, Arnaud, Zalcman, Gérard, Levallet, Guénaëlle, Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), GIP Cyceron (Cyceron), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département de Pathologie [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), CHU Tenon [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Service Pneumologie et allergologie pédiatrique [CHU Toulouse], Pôle Enfants [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Institut Gustave Roussy (IGR), Département de médecine oncologique [Gustave Roussy], Service d'oncologie multidisciplinaire innovations thérapeutiques [Hôpital Nord - APHM], Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital Nord [CHU - APHM], Aix Marseille Université (AMU), Centre d'investigation Clinique [CHU Bichat] - Épidémiologie clinique (CIC 1425), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pôle Thorax et Vaisseaux [CHU Grenoble], Centre Hospitalier Universitaire [Grenoble] (CHU), Centre Hospitalier Le Mans (CH Le Mans), Service de pneumologie [Rennes] = Pneumology [Rennes], CHU Pontchaillou [Rennes], Intergroupe Francophone de Cancérologie Thoracique [Paris] (IFCT), Intergroupe Francophone de Cancérologie thoracique, Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), CHU Lille, Unité de génétique et biologie des cancers (U830), Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Brunaud, Carole, Service d'Anatomie et cytologie pathologiques [CHU Tenon], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
[SDV] Life Sciences [q-bio], Mesothelioma, Lung Neoplasms, Cell Line, Tumor, Pleural Neoplasms, [SDV]Life Sciences [q-bio], Mesothelioma, Malignant, Humans, malignant pleural mesothelioma, amphiregulin, YAP
Abstract

CERVOXY; International audience; The Hippo pathway effector YAP is dysregulated in malignant pleural mesothelioma (MPM). YAP’s target genes include the secreted growth factor amphiregulin (AREG), which is overexpressed in a wide range of epithelial cancers and plays an elusive role in MPM. We assayed the expression of YAP and AREG in MPM pathology samples and that of AREG additionally in plasma samples of patients from the randomized phase 3 IFCT-0701 Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS) using immunohistochemistry and ELISA assays, respectively. MPM patients frequently presented high levels of tumor AREG (64.3%), a high cytosolic AREG expression being predictive of a better prognosis with longer median overall and progression-free survival. Surprisingly, tumor AREG cytosolic expression was not correlated with secreted plasma AREG. By investigating the AREG metabolism and function in MPM cell lines H2452, H2052, MSTO-211H, and H28, in comparison with the T47D ER+ breast cancer cell line used as a positive control, we confirm that AREG is important for cell invasion, growth without anchorage, proliferation, and apoptosis in mesothelioma cells. Yet, most of these MPM cell lines failed to correctly execute AREG post-translational processing by metalloprotease ADAM17/tumor necrosis factor-alpha-converting enzyme (TACE) and extra-cell secretion. The favorable prognostic value of high cytosolic AREG expression in MPM patients could therefore be sustained by default AREG post-translational processing and release. Thus, the determination of mesothelioma cell AREG content could be further investigated as a prognostic marker for MPM patients and used as a stratification factor in future clinical trials.

Published
2022

36. Investigating Tunneling Nanotubes in Cancer Cells: Guidelines for Structural and Functional Studies through Cell Imaging

Author

Dubois, Fatéméh, Bénard, Magalie, Jean-Jacques, Bastien, Schapman, Damien, Roberge, Hélène, Lebon, Alexis, Goux, Didier, Monterroso, Baptiste, Elie, Nicolas, Komuro, Hitoshi, Bazille, Céline, Levallet, Jérôme, Bergot, Emmanuel, Levallet, Guénaëlle, and Galas, Ludovic

Subjects
Article Subject
Abstract

By allowing insured communication between cancer cells themselves and with the neighboring stromal cells, tunneling nanotubes (TNTs) are involved in the multistep process of cancer development from tumorigenesis to the treatment resistance. However, despite their critical role in the biology of cancer, the study of the TNTs has been announced challenging due to not only the absence of a specific biomarker but also the fragile and transitory nature of their structure and the fact that they are hovering freely above the substratum. Here, we proposed to review guidelines to follow for studying the structure and functionality of TNTs in tumoral neuroendocrine cells (PC12) and nontumorigenic human bronchial epithelial cells (HBEC-3, H28). In particular, we reported how crucial is it (i) to consider the culture conditions (culture surface, cell density), (ii) to visualize the formation of TNTs in living cells (mechanisms of formation, 3D representation), and (iii) to identify the cytoskeleton components and the associated elements (categories, origin, tip, and formation/transport) in the TNTs. We also focused on the input of high-resolution cell imaging approaches including Stimulated Emission Depletion (STED) nanoscopy, Transmitted and Scanning Electron Microscopies (TEM and SEM). In addition, we underlined the important role of the organelles in the mechanisms of TNT formation and transfer between the cancer cells. Finally, new biological models for the identification of the TNTs between cancer cells and stromal cells (liquid air interface, ex vivo, in vivo) and the clinical considerations will also be discussed.

Published
2020
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38. Cytosolic amphiregulin accumulation in malignant pleural mesothelioma cells predicts better survival of patient from the IFCT-GFPC-0701 MAPS Phase 3 trial

Author

Lainé, Baptiste, Maille, Elodie, Levallet, Jérôme, Dubois, Fatéméh, Antoine, Martine, Danel, Claire, Creveuil, Christian, Bergot, Emmanuel, Sherpereel, Arnaud, Langlais, Alexandra, Morin, Franck, Zalcman, Gérard, Levallet, Guénaëlle, Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Service de pneumologie [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), The departments of Pulmonary and Thoracic Oncology and Thoracic Surgery, Calmette Hospital, Lille, France, and Couteau, Florence

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

CERVOXY COLL; National audience

Published
2019

39. L’expression cytosolique tumorale d’amphireguline prédit la meilleure survie des patients atteints de mésothéliome pleural malin : analyses chez 288 patients de la cohorte Bio-MAPS

Author

Lainé, Baptiste, Maille, Elodie, Dubois, Fatéméh, Levallet, Jérôme, Antoine, Martine, Danel, Claire, Creveuil, Christian, Bergot, Emmanuel, Sherpereel, Arnaud, Langlais, Alexandra, Morin, Franck, Zalcman, Gérard, Levallet, Guénaëlle, Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), and Couteau, Florence

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

CERVOXY; National audience

Published
2019

40. Role of the YAP-1 Transcriptional Target cIAP2 in the Differential Susceptibility to Chemotherapy of Non-Small-Cell Lung Cancer (NSCLC) Patients with Tumor RASSF1A Gene Methylation from the Phase 3 IFCT-0002 Trial

Author

Dubois, Fatéméh, primary, Keller, Maureen, additional, Hoflack, Julien, additional, Maille, Elodie, additional, Antoine, Martine, additional, Westeel, Virginie, additional, Bergot, Emmanuel, additional, Quoix, Elisabeth, additional, Lavolé, Armelle, additional, Bigay-Game, Laurence, additional, Pujol, Jean-Louis, additional, Langlais, Alexandra, additional, Morin, Franck, additional, Zalcman, Gérard, additional, and Levallet, Guénaëlle, additional

Published
2019
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41. L’expression cytosolique tumorale d’amphiréguline prédit la meilleure survie des patients atteints de mésothéliome pleural malin : analyses chez 288 patients de la cohorte Bio-MAPS

Author

Levallet, Jérôme, primary, Maille, Elodie, additional, Dubois, Fatéméh, additional, Antoine, Martine, additional, Danel, Claire, additional, Creveuil, Christian, additional, Bergot, Emmanuel, additional, Sherpereel, Arnaud, additional, Langlais, Alexandra, additional, Morin, Franck, additional, Zalcman, Gérard, additional, and Levallet, Guénaëlle, additional

Published
2019
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42. La formation des tunneling nanotubes compense l’altération de l’autophagie des cellules épithéliales bronchiques humaines dépourvues de RASSF1A permettant ainsi leur adaptation aux stress cellulaires

Author

Dubois, Fatéméh, primary, Maille, Elodie, additional, Bénard, Magalie, additional, Elie, Nicolas, additional, Galas, Ludovic, additional, Schapman, Damien, additional, Keller, Maureen, additional, Zalcman, Gérard, additional, and Levallet, Guénaëlle, additional

Published
2019
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43. Les cellules de la lignée bronchique humaine (HBEC-3) n’exprimant plus le gène suppresseur de tumeur RASSF1A acquièrent la capacité d’établir des jonctions communicantes « longue distance »

Author

Jean-Jacques, Bastien, Dubois, Fatéméh, Keller, Maureen, Galas, L, Bénard, M, Schapman, D, Bergot, Emmanuel, Zalcman, G, Levallet, Guénaëlle, Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Centre National de la Recherche Scientifique (CNRS)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Service de pneumologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Cancers et préventions, Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Normandie Université (NU), Couteau, Florence, Brunaud, Carole, Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), and Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

CERVOXY CLIN; National audience

Published
2017

45. MSH2/BRCA1 expression as a DNA-repair signature predicting survival in early-stage lung cancer patients from the IFCT-0002 Phase 3 Trial

Author

Levallet, Guénaëlle, primary, Dubois, Fatéméh, additional, Fouret, Pierre, additional, Antoine, Martine, additional, Brosseau, Solenn, additional, Bergot, Emmanuel, additional, Beau-Faller, Michèle, additional, Gounant, Valérie, additional, Brambilla, Elisabeth, additional, Debieuvre, Didier, additional, Molinier, Olivier, additional, Galateau-Sallé, Françoise, additional, Mazieres, Julien, additional, Quoix, Elisabeth, additional, Pujol, Jean-Louis, additional, Moro-Sibilot, Denis, additional, Langlais, Alexandra, additional, Morin, Franck, additional, Westeel, Virginie, additional, and Zalcman, Gérard, additional

Published
2016
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46. RASSF1A et nanotubes, quel lien dans les cellules de lignées épithéliales bronchiques humaines

Author

Dubois, Fatéméh, Keller, Maureen, Zalcman, G, Levallet, Guenaëlle, Imagerie et Stratégies Thérapeutiques des pathologies Cérébrales et Tumorales (ISTCT), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU), Service de pneumologie [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), and Couteau, Florence

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio]
Abstract

CERVOXY CLIN; National audience

Published
2015

47. Cancer and RASSF1A/RASSF1C, the Two Faces of Janus

Author

Dubois, Fatéméh, Bergot, Emmanuel, and Levallet, Guénaëlle

Abstract

Although encoded by the same gene, RASSF1A and RASSF1C are two opposites in carcinogenesis; one is a tumor suppressor that is silenced in a plethora of cancers, while the other is an oncogene that remains unaffected. Here, we aim to understand why and to highlight their respective clinical implications.

Published
2024
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49. RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non–Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway

Author

Dubois, Fatéméh, primary, Keller, Maureen, additional, Calvayrac, Olivier, additional, Soncin, Fabrice, additional, Hoa, Lily, additional, Hergovich, Alexander, additional, Parrini, Maria-Carla, additional, Mazières, Julien, additional, Vaisse-Lesteven, Mélissa, additional, Camonis, Jacques, additional, Levallet, Guénaëlle, additional, and Zalcman, Gérard, additional

Published
2016
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