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4 results on '"Dubisova, Maria"'

2. Simultaneous targeting of mitochondrial metabolism and immune checkpoints as a new strategy for renal cancer therapy

Author

Stemberkova‐Hubackova, Sona, primary, Zobalova, Renata, additional, Dubisova, Maria, additional, Smigova, Jana, additional, Dvorakova, Sarka, additional, Korinkova, Klara, additional, Ezrova, Zuzana, additional, Endaya, Berwini, additional, Blazkova, Kristyna, additional, Vlcak, Erik, additional, Brisudova, Petra, additional, Le, Dan‐Diem Thi, additional, Juhas, Stefan, additional, Rosel, Daniel, additional, Daniela Kelemen, Cristina, additional, Sovilj, Dana, additional, Vacurova, Eliska, additional, Cajka, Tomas, additional, Filimonenko, Vlada, additional, Dong, Lanfeng, additional, Andera, Ladislav, additional, Hozak, Pavel, additional, Brabek, Jan, additional, Bielcikova, Zuzana, additional, Stursa, Jan, additional, Werner, Lukas, additional, and Neuzil, Jiri, additional

Published
2022
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3. The adaptor protein Miro1 modulates horizontal transfer of mitochondria in mouse melanoma models

Author

Novak, Jaromir, Nahacka, Zuzana, Oliveira, Gabriela L., Brisudova, Petra, Dubisova, Maria, Dvorakova, Sarka, Miklovicova, Sona, Dalecka, Marketa, Puttrich, Verena, Grycova, Lenka, Magalhaes-Novais, Silvia, Correia, Catarina Mendes, Levoux, Jennifer, Stepanek, Ludek, Prochazka, Jan, Svec, David, Reguera, David Pajuelo, Lopez-Domenech, Guillermo, Zobalova, Renata, Sedlacek, Radek, Terp, Mikkel G., Gammage, Payam A., Lansky, Zdenek, Kittler, Josef, Oliveira, Paulo J., Ditzel, Henrik J., Berridge, Michael V., Rodriguez, Anne-Marie, Boukalova, Stepana, Rohlena, Jakub, and Neuzil, Jiri

Abstract

Recent research has shown that mtDNA-deficient cancer cells (ρ0cells) acquire mitochondria from tumor stromal cells to restore respiration, facilitating tumor formation. We investigated the role of Miro1, an adaptor protein involved in movement of mitochondria along microtubules, in this phenomenon. Inducible Miro1 knockout (Miro1KO) mice markedly delayed tumor formation after grafting ρ0cancer cells. Miro1KOmice with fluorescently labeled mitochondria revealed that this delay was due to hindered mitochondrial transfer from the tumor stroma to grafted B16 ρ0cells, impeding recovery of mitochondrial respiration, and tumor growth. Miro1KOled to the perinuclear accumulation of mitochondria and impaired mobility of the mitochondrial network. In vitroexperiments revealed decreased association of mitochondria with microtubules, compromising mitochondrial transfer via tunneling nanotubes (TNTs) in mesenchymal stromal cells. Here we show the role of Miro1 in horizontal mitochondrial transfer in mouse melanoma models in vivoand its involvement with TNTs.

Published
2025
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4. Miro proteins connect mitochondrial function and intercellular transport.

Author

Nahacka, Zuzana, Zobalova, Renata, Dubisova, Maria, Rohlena, Jakub, and Neuzil, Jiri

Subjects
MITOCHONDRIAL proteins, CELL physiology, EUKARYOTIC cells, MITOCHONDRIA, CELL growth
Abstract

Mitochondria are organelles present in most eukaryotic cells, where they play major and multifaceted roles. The classical notion of the main mitochondrial function as the powerhouse of the cell per se has been complemented by recent discoveries pointing to mitochondria as organelles affecting a number of other auxiliary processes. They go beyond the classical energy provision via acting as a relay point of many catabolic and anabolic processes, to signaling pathways critically affecting cell growth by their implication in de novo pyrimidine synthesis. These additional roles further underscore the importance of mitochondrial homeostasis in various tissues, where its deregulation promotes a number of pathologies. While it has long been known that mitochondria can move within a cell to sites where they are needed, recent research has uncovered that mitochondria can also move between cells. While this intriguing field of research is only emerging, it is clear that mobilization of mitochondria requires a complex apparatus that critically involves mitochondrial proteins of the Miro family, whose role goes beyond the mitochondrial transfer, as will be covered in this review. [ABSTRACT FROM AUTHOR]

Published
2021
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