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253 results on '"Dubernard, G"'

1. Management of women with abnormal uterine bleeding: Clinical practice guidelines of the French National College of Gynaecologists and Obstetricians (CNGOF)

Author

Brun, J.L., Plu-Bureau, G., Huchon, C., Ah-Kit, X., Barral, M., Chauvet, P., Cornelis, F., Cortet, M., Crochet, P., Delporte, V., Dubernard, G., Giraudet, G., Gosset, A., Graesslin, O., Hugon-Rodin, J., Lecointre, L., Legendre, G., Maitrot-Mantelet, L., Marcellin, L., Miquel, L., Le Mitouard, M., Proust, C., Roquette, A., Rousset, P., Sangnier, E., Sapoval, M., Thubert, T., Torre, A., Trémollières, F., Vernhet-Kovacsik, H., Vidal, F., and Marret, H.

Published
2023
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2. Prise en charge des ménorragies : recommandations pour la pratique clinique du Collège national des gynécologues et obstétriciens français (CNGOF)

Author

Brun, J.-L., Plu-Bureau, G., Huchon, C., Ah-Kit, X., Barral, M., Chauvet, P., Cornelis, F., Cortet, M., Crochet, P., Delporte, V., Dubernard, G., Giraudet, G., Gosset, A., Graesslin, O., Hugon-Rodin, J., Lecointre, L., Legendre, G., Maitrot-Mantelet, L., Marcellin, L., Miquel, L., Le Mitouard, M., Proust, C., Roquette, A., Rousset, P., Sangnier, E., Sapoval, M., Thubert, T., Torre, A., Trémollières, F., Vernhet-Kovacsik, H., Vidal, F., and Marret, H.

Published
2022
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4. Evaluating the safety of high-intensity focused ultrasound treatment for rectal endometriosis: results from a French prospective multicentre study including 60 patients.

Author

Dubernard, G, Maissiat, E, Legendre, G, Dennis, T, Capmas, P, Warembourg, S, Descamps, P, Chavrier, F, Roman, H, Fernandez, H, Nguyen-Ba, E, Merlot, B, Rousset, P, Lafon, C, and Philip, Charles-André

Subjects
*HIGH-intensity focused ultrasound, *ULTRASONIC therapy, *THERAPEUTICS, *VISUAL analog scale, *ULTRASONIC waves
Abstract

STUDY QUESTION Is increasing the intensity of high-intensity focused ultrasound (HIFU) by 30% in the treatment of rectal endometriosis a safe procedure? SUMMARY ANSWER This study demonstrates the safety of a 30% increase in the intensity of HIFU in the treatment of rectal endometriosis, with no Clavien–Dindo Grade III complications overall, and namely no rectovaginal fistulae. WHAT IS KNOWN ALREADY A feasibility study including 20 patients with rectal endometriosis demonstrated, with no severe complications, a significant improvement in digestive disorders, dysmenorrhoea, dyspareunia, and health status, although the volume of the endometriosis nodule did not appear to be reduced. STUDY DESIGN, SIZE, DURATION A prospective multicentre cohort study was conducted between 2020 and 2022 with 60 patients with symptomatic rectal endometriosis. Following the failure of medical treatment, HIFU treatment was offered as an alternative to surgery. PARTICIPANTS/MATERIALS, SETTING, METHODS As the main objective of this study was to examine safety, all adverse events observed during the 6 months of follow-up were analysed and graded according to the National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) and Clavien–Dindo classifications. Secondary objectives included evaluating the evolution of symptoms using validated questionnaires: gynaecological and digestive pain symptoms with a visual analogue scale, health status with the Medical Outcomes Study 36-item Short Form (SF-36) questionnaire, average post-operative daily pain level, and analgesic medication required in the 10 days following treatment. MRI was also performed at Day 1 to detect early complications. Finally, we performed a blinded MRI review of the evolution of the nodule at 6 months post-treatment. MAIN RESULTS AND THE ROLE OF CHANCE The procedure was performed under spinal anaesthesia for 30% of the patients. The median duration of treatment was 32 min. Fifty-five patients left the hospital on Day 1. MRI scans performed on Day 1 did not highlight any early-onset post-operative complication. Using the Clavien–Dindo classification, we listed 56.7% Grade I events, 3.4% Grade II events, and no events Grade III or higher. At 1, 3, and 6 months, all gynaecologic, digestive and general symptoms, as well as health status, had significantly improved. The evolution of the nodule was also significant (P  < 0.001) with a 28% decrease in volume. LIMITATIONS, REASONS FOR CAUTION The main objective was safety and not effectiveness. The study was not randomized and there was no control group. WIDER IMPLICATIONS OF THE FINDINGS HIFU treatment for rectal endometriosis results in an improvement of symptoms with low morbidity; as such, for selected patients, it could be a valuable alternative to surgical approaches following the failure of medical treatment. STUDY FUNDING/COMPETING INTEREST(S) The study was funded by the company EDAP TMS. Professors Dubernard and Rousset are consultants for EDAP TMS. Dubernard received travel support from EDAP-TMS. Dr F. Chavrier received industrial grants from EDAP-TMS. He has developed a device for generating focused ultrasonic waves with reduced treatment time. This device has been patented by EDAP-TMS. Dr Lafon received industrial grants from EDAP-TMS; he declares that EDAP-TMS provided funding directly to INSERM to support a young researcher chair in therapeutic ultrasound, which is unrelated to the current study. TRIAL REGISTRATION NUMBER ClinicalTrials.gov identifier NCT04494568. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Management of endometriosis: CNGOF/HAS clinical practice guidelines – Short version

Author

Collinet, P., Fritel, X., Revel-Delhom, C., Ballester, M., Bolze, P.A., Borghese, B., Bornsztein, N., Boujenah, J., Brillac, T., Chabbert-Buffet, N., Chauffour, C., Clary, N., Cohen, J., Decanter, C., Denouël, A., Dubernard, G., Fauconnier, A., Fernandez, H., Gauthier, T., Golfier, F., Huchon, C., Legendre, G., Loriau, J., Mathieu-d’Argent, E., Merlot, B., Niro, J., Panel, P., Paparel, P., Philip, C.A., Ploteau, S., Poncelet, C., Rabischong, B., Roman, H., Rubod, C., Santulli, P., Sauvan, M., Thomassin-Naggara, I., Torre, A., Wattier, J.M., Yazbeck, C., Bourdel, N., and Canis, M.

Published
2018
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13. OC12.01: Evaluation of rectal endometriosis treatment with high‐intensity focused ultrasound versus surgery: a retrospective multicentric study.

Author

Dubernard, G. and Roman, H.

Subjects
*FECAL incontinence, *THERAPEUTICS, *PELVIC pain, *SPASMS, *DATABASES
Abstract

This article compares the treatment of rectal endometriosis using high-intensity focused ultrasound (HIFU) versus surgery. The study involved 120 patients, with 60 in each group. The results showed that HIFU treatment had a lower rate of complications and shorter hospitalization duration compared to surgery. Both treatments showed significant improvement in symptoms and quality of life outcomes at 6 months. The study suggests that HIFU could be an alternative to surgical treatment for suitable patients, but further research is needed to assess long-term complications and relapse risks. [Extracted from the article]

Published
2024
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41. Management of endometriosis

Author

Collinet, P., primary, Fritel, X., additional, Revel-Delhom, C., additional, Ballester, M., additional, Bolze, P.A., additional, Borghese, B., additional, Bornsztein, N., additional, Boujenah, J., additional, Brillac, T., additional, Chabbert-Buffet, N., additional, Chauffour, C., additional, Clary, N., additional, Cohen, J., additional, Decanter, C., additional, Denouël, A., additional, Dubernard, G., additional, Fauconnier, A., additional, Fernandez, H., additional, Gauthier, T., additional, Golfier, F., additional, Huchon, C., additional, Legendre, G., additional, Loriau, J., additional, Mathieu-d’Argent, E., additional, Merlot, B., additional, Niro, J., additional, Panel, P., additional, Paparel, P., additional, Philip, C.A., additional, Ploteau, S., additional, Poncelet, C., additional, Rabischong, B., additional, Roman, H., additional, Rubod, C., additional, Santulli, P., additional, Sauvan, M., additional, Thomassin-Naggara, I., additional, Torre, A., additional, Wattier, J.M., additional, Yazbeck, C., additional, Bourdel, N., additional, and Canis, M., additional

Published
2018
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43. Prise en charge de l’endométriose : recommandations pour la pratique clinique CNGOF-HAS (texte court)

Author

Collinet, P., primary, Fritel, X., additional, Revel-Delhom, C., additional, Ballester, M., additional, Bolze, P.A., additional, Borghese, B., additional, Bornsztein, N., additional, Boujenah, J., additional, Bourdel, N., additional, Brillac, T., additional, Chabbert-Buffet, N., additional, Chauffour, C., additional, Clary, N., additional, Cohen, J., additional, Decanter, C., additional, Denouël, A., additional, Dubernard, G., additional, Fauconnier, A., additional, Fernandez, H., additional, Gauthier, T., additional, Golfier, F., additional, Huchon, C., additional, Legendre, G., additional, Loriau, J., additional, Mathieu-d’Argent, E., additional, Merlot, B., additional, Niro, J., additional, Panel, P., additional, Paparel, P., additional, Philip, C.A., additional, Ploteau, S., additional, Poncelet, C., additional, Rabischong, B., additional, Roman, H., additional, Rubod, C., additional, Santulli, P., additional, Sauvan, M., additional, Thomassin-Naggara, I., additional, Torre, A., additional, Wattier, J.M., additional, Yazbeck, C., additional, and Canis, M., additional

Published
2018
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49. Management of presumed benign ovarian tumors: updated French guidelines

Author

Brun, J.-L., primary, Fritel, X., additional, Aubard, Y., additional, Borghese, B., additional, Bourdel, N., additional, Chabbert-Buffet, N., additional, Collinet, P., additional, Deffieux, X., additional, Dubernard, G., additional, Huchon, C., additional, Kalfa, N., additional, Lahlou, N., additional, Marret, H., additional, Pienkowski, C., additional, Sevestre, H., additional, Thomassin-Naggara, I., additional, and Levêque, J., additional

Published
2014
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50. Urgences ophtalmologiques non traumatiques

Author

Labetoulle, Marc, Dubernard, G, Offret, H, Virologie moléculaire et structurale (VMS), Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS), Inconnu, and ProdInra, Migration

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

National audience

Published
2006

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