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© 2023. The Author(s). BACKGROUND: Malaria remains one of the most serious public health problems in sub-Saharan Africa and Mozambique is the world's fourth largest contributor, with 4.7% of disease cases and 3.6% of total deaths due to malaria. Its control relies on the fight against the vector and treatment of confirmed cases with anti-malarial drugs. Molecular surveillance is an important tool for monitoring the spread of anti-malarial drug resistance. METHODS: A cross-sectional study recruited 450 participants with malaria infection detected by Rapid Diagnostic Tests, from three different study sites (Niassa, Manica and Maputo) between April and August 2021. Correspondent blood samples were collected on filter paper (Whatman® FTA® cards), parasite DNA extracted and pfk13 gene sequenced using Sanger method. SIFT software (Sorting Intolerant From Tolerant) was used, predict whether an amino acid substitution affects protein function. RESULTS: No pfkelch13-mediated artemisinin resistance gene mutation was detected in this study settings. However, non-synonymous mutations were detected at prevalence of 10.2%, 6% and 5% in Niassa, Manica and Maputo, respectively. Most (56.3%) of the reported non-synonymous mutations were due to substitution at the first base of the codon, 25% at the second base and 18.8% at the third base. Additionally, 50% of non-synonymous mutations showed a SIFTscore bellow cut off value of 0.05, therefore, they were predicted to be deleterious. CONCLUSION: These results do not show an emergence of artemisinin resistance cases in Mozambique. However, the increased number of novel non-synonymous mutations highlights the relevance of increasing the number of studies focused on the molecular surveillance of artemisinin resistance markers, for its early detection. publishersversion published

The world's cities are growing in size and number. At the same time, the global climate change rises global average temperatures as well as increase weather extreme events. Sao Paulo, the 5th urbanized region in the world, has currently more than 11 million inhabitants and recent studies alert for the increased frequency of extreme climate/weather events in the city. In this context, this work presents an interdisciplinary research experience, based at the Architecture and Urbanism school in partnership with the Atmospheric Sciences' Department, approaching the interdependences between urban morphology, green infrastructure, and microclimate in São Paulo, aiming to discuss planning, urban and building design alternatives to counterbalance urban warming effects in a subtropical changing climate. The research team, led by an architecture researcher and an associate researcher from atmospheric sciences, includes a post-doc researcher, graduate and undergraduate students, engaging architecture, urban design, planning, and meteorology dealing with the role of planning, urban and building design for climate change adaptation. This paper briefly summarizes what we have learnt with remote sensing, measurements and numerical simulation encompassing the metropolitan, the neighbourhood and the building scales and discuss the results of an interdisciplinary research empowering architectural education in different levels. Resumen Las ciudades del mundo están creciendo en tamaño y número. Al mismo tiempo, el cambio climático global eleva las temperaturas medias del planeta y aumenta los fenómenos meteorológicos extremos. Sao Paulo, la quinta región urbanizada del mundo, tiene actualmente más de 11 millones de habitantes y estudios recientes alertan sobre el aumento de la frecuencia de los eventos climáticos/ meteorológicos extremos en la ciudad. En este contexto, este trabajo presenta una experiencia de investigación interdisciplinaria, basada en la escuela de Arquitectura y Urbanismo en colaboración con el Departamento de Ciencias Atmosféricas, que aborda las interdependencias entre la morfología urbana, la infraestructura verde y el microclima en Sao Paulo, con el objetivo de discutir alternativas de planificación, diseño urbano y de edificios para contrarrestar los efectos del calentamiento urbano en un clima subtropical cambiante. El equipo de investigación, dirigido por un investigador de arquitectura y un investigador asociado de ciencias atmosféricas, incluye un investigador postdoctoral, estudiantes de grado y de posgrado, que se dedican a la arquitectura, el diseño urbano, la planificación y la meteorología y que tratan el papel de la planificación, el diseño urbano y de edificios para la adaptación al cambio climático. Este artículo resume brevemente lo que hemos aprendido con la teledetección, las mediciones y la simulación numérica, abarcando las escalas metropolitanas, de barrio y de edificio, y discute los resultados de una investigación interdisciplinaria que potencia la educación arquitectónica en diferentes niveles.

Las ciudades del mundo están creciendo en tamaño y número. Al mismo tiempo, el cambio climático global eleva las temperaturas medias del planeta y aumenta los fenómenos meteorológicos extremos. Sao Paulo, la quinta región urbanizada del mundo, tiene actualmente más de 21 millones de habitantes y estudios recientes alertan sobre el aumento de la frecuencia de los eventos climáticos/ meteorológicos extremos en la ciudad. En este contexto, este trabajo presenta una experiencia de investigación interdisciplinaria, basada en la escuela de Arquitectura y Urbanismo en colaboración con el Departamento de Ciencias Atmosféricas, que aborda las interdependencias entre la morfología urbana, la infraestructura verde y el microclima en Sao Paulo, con el objetivo de discutir alternativas de planificación, diseño urbano y de edificios para contrarrestar los efectos del calentamiento urbano en un clima subtropical cambiante. El equipo de investigación, dirigido por un investigador de arquitectura y un investigador asociado de ciencias atmosféricas, incluye un investigador postdoctoral, estudiantes de grado y de posgrado, que se dedican a la arquitectura, el diseño urbano, la planificación y la meteorología y que tratan el papel de la planificación, el diseño urbano y de edificios para la adaptación al cambio climático. Este artículo resume brevemente lo que hemos aprendido con la teledetección, las mediciones y la simulación numérica, abarcando las escalas metropolitanas, de barrio y de edificio, y discute los resultados de una investigación interdisciplinaria que potencia la educación arquitectónica en diferentes niveles. The world’s cities are growing in size and number. At the same time, the global climate change rises global average temperatures as well as increase weather extreme events. Sao Paulo, the 5th urbanized region in the world, has currently more than 21 million inhabitants and recent studies alert for the increased frequency of extreme climate/weather events in the city. In this context, this work presents an interdisciplinary research experience, based at the Architecture and Urbanism school in partnership with the Atmospheric Sciences’ Department, approaching the interdependencies between urban morphology, green infrastructure, and microclimate in São Paulo, aiming to discuss planning, urban and building design alternatives to counterbalance urban warming effects in a subtropical changing climate. The research team, led by an architecture researcher and an associate researcher from atmospheric sciences, includes a post-doc researcher, graduate and undergraduate students, engaging architecture, urban design, planning, and meteorology dealing with the role of planning, urban and building design for climate change adaptation. This paper briefly summarizes what we have learnt with remote sensing, measurements and numerical simulation encompassing the metropolitan, the neighbourhood and the building scales and discuss the results of an interdisciplinary research empowering architectural education in different levels.

The article discusses how the intensification of urban climate changes may affect population’s health and alter the incidence pattern of Acute Myocardial Infarction (AMI). The study starts with the statistics of the public hospital admissions due to AMI in the City of São Paulo and compares the data with the monthly results of maximum average temperature, minimum average temperature, average temperature and hours of sunlight. The authors emphasize the need to analyse the whole climate data in order to study their effects on human organism. The studied period comprised January 2000 to December 2017.The atmospheric levels of SO2, CO, NO2 and O3 were also analyzed in the time periods under evaluation. The results show the impacts of the intensification of urban heating on the pattern of public hospital admissions due to AMI. The conclusion is that urban heating may affect public health, justifying the need for further studies on this subject. Discute-se como a intensificação das mudanças climáticas urbanas pode afetar a saúde da população e alterar o padrão de incidência do Infarto Agudo do Miocárdio. O estudo compara os dados sobre as Internações Hospitalares no SUS por Infarto Agudo do Miocárdio (IAM) na cidade de São Paulo com os resultados mensais da temperatura máxima média, da temperatura mínima média, da temperatura compensada média e da insolação total. Salienta-se a importância da análise conjunta dos dados climatológicos quando se deseja estudar os seus efeitos sobre o organismo humano. O período de estudo foi de Janeiro de 2000 a Dezembro de 2017. Os níveis atmosféricos de SO2, CO, NO2 e O3 também foram analisados nos períodos avaliados. Os resultados evidenciaram os reflexos da acentuação do calor urbano sobre o padrão das internações hospitalares por IAM no SUS. Conclui-se que a saúde da população urbana pode estar sendo afetada pelo aquecimento urbano, justificando a necessidade de maiores estudos sobre o assunto.

Inspired by previous disclosure of room-temperature ionic liquids derived from primaquine and cinnamic acids, which displayed slightly enhanced blood-stage activity compared to the parent drug, we have now combined this emblematic antimalarial with natural fatty acids. This affords surface-active ionic liquids whose liver-stage antiplasmodial activity is either retained or slightly enhanced, while revealing blood-stage antiplasmodial activity at least one order of magnitude higher than that of the parent compound. These findings open new perspectives towards the cost-effective recycling of classical drugs that are either shelved or in decline, and which is not limited to antimalarial agents.