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533 results on '"Duarte, Ana Rita C."'

5. How do we drive deep eutectic systems towards an industrial reality?

Author

Paiva, Alexandre, Matias, Ana A., and Duarte, Ana Rita C.

Subjects
Physics - Chemical Physics
Abstract

Deep eutectic systems (DES) have received considerable attention in the past 5 years of research. Up to 2013 little had been explored over these systems both in which concerns fundamentals and applications. The definition of a deep eutectic system is still controversial and in this manuscript we highlight the different definitions proposed in the literature and discuss what, in our opinion, should be pursued in order to have an agreement in the scientific community studying this field. From the definition of DES to its applications also interesting changes have been observed in the topics published. From electrochemistry to newer applications, such as cryopreservation, the field is evolving as new outcomes on DES properties are unraveled. We herein present and discuss new trends on DES research and present some perspectives on what we consider to be the most promising applications of DES at industrial scale.

Published
2019

22. List of contributors

Author

AbdElhamid, Ahmed S., primary, Acquah, Caleb, additional, Bandaru, Ravi, additional, Beckers, Henny J.M., additional, Bekhit, Adnan A., additional, Bertens, Christian J.F., additional, Cano, Amanda, additional, Çapan, Yılmaz, additional, da Silva, Classius Ferreira, additional, Dandela, Rambabu, additional, Danquah, Michael K., additional, de Melo Barbosa, Raquel, additional, Deshmukh, Rohitas, additional, Duarte, Ana Rita C., additional, Elkhodairy, Kadria A., additional, Elzoghby, Ahmed O., additional, Gijs, Marlies, additional, Greish, Khaled, additional, Hacioglu, Nelin, additional, Hamid, Hinna, additional, Handa, Mayank, additional, Hassanin, Islam A., additional, Jeevanandam, Jaison, additional, Jha, Shikha, additional, Kenguva, Gowtham, additional, Kesharwani, Prashant, additional, Khairnar, Pooja S., additional, Khattab, Sherine N., additional, Kockar, Feray, additional, Kulabhusan, Prabir Kumar, additional, Nasser, Tasneem A., additional, Nuijts, Rudy M.M.A., additional, Rajak, Harish, additional, Rout, Smruti Rekha, additional, Sahebkar, Amirhossein, additional, Santos, Filipa, additional, Sarwar Alam, Mohammad, additional, Severino, Patrícia, additional, Shama, Ahmed N., additional, Sheikh, Afsana, additional, Shukla, Rahul, additional, Singh, Vanshikha, additional, Souto, Eliana B., additional, Talegaonkar, Sushama, additional, Teleb, Mohamed, additional, Tokay, Esra, additional, Tonbul, Hayrettin, additional, Trivedi, Vishal, additional, Wasnik, Samiksha, additional, Wolters, Jarno E.J., additional, Zielińska, Aleksandra, additional, and Şahin, Adem, additional

Published
2022
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25. A novel collagen aerogel with relevant features for topical biomedical applications

Author

Batista, Miguel P., Schröter, Baldur, Fernández, Naiara, Bustos Gaspar, Frédéric, Rosário Bronze, Maria do, Duarte, Ana Rita C., Gurikov, Pavel, Batista, Miguel P., Schröter, Baldur, Fernández, Naiara, Bustos Gaspar, Frédéric, Rosário Bronze, Maria do, Duarte, Ana Rita C., and Gurikov, Pavel

Abstract

Collagen-based aerogels have great potential for topical biomedical applications. Collagen's natural affinity with skin, biodegradability, and gelling behavior are compelling properties to combine with the structural integrity of highly porous matrices in the dry form (aerogels). This work aimed to produce a novel collagenbased aerogel and to perform the material's solid-state and physicochemical characterization. Aerogels were obtained by performing different solvent exchange approaches of a collagengelled extract and drying the obtained alcogels with supercritical CO2. The resulting aerogels showed a sponge-like structure with a relatively dense mesoporous network with a specific surface area of 201–203 m2/g, a specific pore volume of 1.08–1.15 cm3/g, and a mean pore radius of ca. 14.7 nm. Physicochemical characterization confirmed that the obtained aerogels are composed of pure collagen, and the aerogel production process does not impact protein tertiary structure. Finally, the material swelling behavior was assessed at various pH values (4, 7, and 10). Collagen aerogels presented a high water uptake capacity up to ~2700 wt.%, pH-dependent stability, and swelling behavior in aqueous media. The results suggest that this collagen aerogel could be a promising scaffold candidate for topical biomedical applications.

Published
2024

32. Supercritical Fluid Technology as a Tool to Prepare Gradient Multifunctional Architectures Towards Regeneration of Osteochondral Injuries

Author

Duarte, Ana Rita C., Santo, Vitor E., Gomes, Manuela E., Reis, Rui L., COHEN, IRUN R., Series Editor, LAJTHA, ABEL, Series Editor, LAMBRIS, JOHN D., Series Editor, PAOLETTI, RODOLFO, Series Editor, REZAEI, NIMA, Series Editor, Oliveira, J. Miguel, editor, Pina, Sandra, editor, Reis, Rui L., editor, and San Roman, Julio, editor

Published
2018
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47. Synthesis, Bioavailability, and Cytotoxicity Studies

Author

Barreira, António, Santos, Andreia F. M., Dionísio, Madalena, Jesus, Ana R., Duarte, Ana Rita C., Petrovski, Željko, Paninho, Ana B., Ventura, Márcia G., Branco, Luís C., DQ - Departamento de Química, and LAQV@REQUIMTE

Subjects
Inorganic Chemistry, levothyroxine (T4), solubility, T4 based ionic liquids (T4-ILs), Organic Chemistry, ionic formulations, cytotoxicity, permeability, Physical and Theoretical Chemistry, Molecular Biology, Catalysis, Spectroscopy, Computer Science Applications
Abstract

Funding Information: Ana R. Jesus and Ana Rita C. Duarte acknowledge the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme, under grant agreement No ERC-2016-CoG 725034. Publisher Copyright: © 2023 by the authors. Thyroid diseases affect a considerable portion of the population, with hypothyroidism being one of the most commonly reported thyroid diseases. Levothyroxine (T4) is clinically used to treat hypothyroidism and suppress thyroid stimulating hormone secretion in other thyroid diseases. In this work, an attempt to improve T4 solubility is made through the synthesis of ionic liquids (ILs) based on this drug. In this context, [Na][T4] was combined with choline [Ch]+ and 1-(2-hydroxyethyl)-3-methylimidazolium [C2OHMiM]+ cations in order to prepare the desired T4-ILs. All compounds were characterized by NMR, ATR-FTIR, elemental analysis, and DSC, aiming to check their chemical structure, purities, and thermal properties. The serum, water, and PBS solubilities of the T4-ILs were compared to [Na][T4], as well as the permeability assays. It is important to note an improved adsorption capacity, in which no significant cytotoxicity was observed against L929 cells. [C2OHMiM][T4] seems to be a good alternative to the commercial levothyroxine sodium salt with promising bioavailability. publishersversion published

Published
2023

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