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1. Intra-abdominal infections survival guide: a position statement by the Global Alliance For Infections In Surgery

Author

Sartelli, Massimo, Barie, Philip, Agnoletti, Vanni, Al-Hasan, Majdi N., Ansaloni, Luca, Biffl, Walter, Buonomo, Luis, Blot, Stijn, Cheadle, William G., Coimbra, Raul, De Simone, Belinda, Duane, Therese M., Fugazzola, Paola, Giamarellou, Helen, Hardcastle, Timothy C., Hecker, Andreas, Inaba, Kenji, Kirkpatrick, Andrew W., Labricciosa, Francesco M., Leone, Marc, Martin-Loeches, Ignacio, Maier, Ronald V., Marwah, Sanjay, Maves, Ryan C., Mingoli, Andrea, Montravers, Philippe, Ordóñez, Carlos A., Palmieri, Miriam, Podda, Mauro, Rello, Jordi, Sawyer, Robert G., Sganga, Gabriele, Tattevin, Pierre, Thapaliya, Dipendra, Tessier, Jeffrey, Tolonen, Matti, Ulrych, Jan, Vallicelli, Carlo, Watkins, Richard R., Catena, Fausto, and Coccolini, Federico

Published
2024
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3. Findings on Repeat Posttraumatic Brain Computed Tomography Scans in Older Patients With Minimal Head Trauma and the Impact of Existing Antithrombotic Use

Author

Helmer, Kenneth S., Curcio, Gary J., Gilligan, Doreen, Taylor, Dallas A., Hughes, Frances, Barker, Ralph J., Bissinger, Carol M., Miller, Charles J., Harbour, Lori F., Duane, Therèse M., Carrick, Matthew M., Lieser, Mark J., Flaherty, Stephen, Blair, Valeria, Perez, Julia, Cervantes, Carli, Hogan, Christopher, Ruiz, Chris R., Tinti, Meredith, Romero, Cecilia A., Jones, Karla J., Neeley, Tara, Wright, Kimberly, Dunne, James, Eversley-Kelso, Tatiana, Harte, Melissa A., Kline, Richard A., Love, Joseph D., van Doorn, Erika, Brock, Christie M., Acuna, David L., Shaddix, Jamie L., Rhodes, Heather, Biswas, Saptarshi, Shillinglaw, William C., Slivinski, Andrea, Offner, Patrick J., Levine, Jeffrey H., Banton, Kaysie L., Katubig, Burt, Watts, Dorraine D., Wilson, Nina Y., Shen, Yan, Garland, Jeneva M., Wyse, Ransom J., Hunt, Darrell L., Gauny, Randy W., and Fakhry, Samir M.

Published
2023
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4. The EGS Grading Scale For Skin And Soft Tissue Infections Is Predictive Of Poor Outcomes

Author

Savage, Stephanie A, Li, Shi Wen, Utter, Garth H, Cox, Jessica A, Wydo, Salina M, Cahill, Kevin, Sarani, Babak, Holzmacher, Jeremy, Duane, Therese M, Gandhi, Rajesh R, Zielinski, Martin D, Ray-Zack, Mohamed, Tierney, Joshua, Chapin, Trinette, Murphy, Patrick B, Vogt, Kelly N, Schroeppel, Thomas J, Callaghan, Emma, Kobayashi, Leslie, Coimbra, Raul, Schuster, Kevin M, Gillaspie, Devin, Timsina, Lava, Louis, Alvancin, and Crandall, Marie

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Health Sciences, Clinical Research, Prevention, Infectious Diseases, Patient Safety, Good Health and Well Being, Abscess, Adult, Aged, Cellulitis, Emergency Treatment, Fasciitis, Female, General Surgery, Humans, Length of Stay, Male, Middle Aged, Necrosis, Observer Variation, Postoperative Complications, Prognosis, Retrospective Studies, Risk Assessment, Skin Diseases, Infectious, Soft Tissue Infections, Survival Rate, United States, EGS grading scales, skin and soft-tissue infections, necrotizing fasciitis, LRINEC score, Clinical sciences, Nursing
Abstract

IntroductionOver the last 5 years, the American Association for the Surgery of Trauma has developed grading scales for emergency general surgery (EGS) diseases. In a previous validation study using diverticulitis, the grading scales were predictive of complications and length of stay. As EGS encompasses diverse diseases, the purpose of this study was to validate the grading scale concept against a different disease process with a higher associated mortality. We hypothesized that the grading scale would be predictive of complications, length of stay, and mortality in skin and soft-tissue infections (STIs).MethodsThis multi-institutional trial encompassed 12 centers. Data collected included demographic variables, disease characteristics, and outcomes such as mortality, overall complications, and hospital and ICU length of stay. The EGS scale for STI was used to grade each infection and two surgeons graded each case to evaluate inter-rater reliability.Results1170 patients were included in this study. Inter-rater reliability was moderate (kappa coefficient 0.472-0.642, with 64-76% agreement). Higher grades (IV and V) corresponded to significantly higher Laboratory Risk Indicator for Necrotizing Fasciitis scores when compared with lower EGS grades. Patients with grade IV and V STI had significantly increased odds of all complications, as well as ICU and overall length of stay. These associations remained significant in logistic regression controlling for age, gender, comorbidities, mental status, and hospital-level volume. Grade V disease was significantly associated with mortality as well.ConclusionThis validation effort demonstrates that grade IV and V STI are significantly predictive of complications, hospital length of stay, and mortality. Though predictive ability does not improve linearly with STI grade, this is consistent with the clinical disease process in which lower grades represent cellulitis and abscess and higher grades are invasive infections. This second validation study confirms the EGS grading scale as predictive, and easily used, in disparate disease processes.Level of evidencePrognostic/Epidemiologic retrospective multicenter trial, level III.

Published
2019

5. Circulation first – the time has come to question the sequencing of care in the ABCs of trauma; an American Association for the Surgery of Trauma multicenter trial

Author

Ferrada, Paula, Callcut, Rachael A, Skarupa, David J, Duane, Therese M, Garcia, Alberto, Inaba, Kenji, Khor, Desmond, Anto, Vincent, Sperry, Jason, Turay, David, Nygaard, Rachel M, Schreiber, Martin A, Enniss, Toby, McNutt, Michelle, Phelan, Herb, Smith, Kira, Moore, Forrest O, Tabas, Irene, Dubose, Joseph, and AAST Multi-Institutional Trials Committee

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Physical Injury - Accidents and Adverse Effects, Clinical Trials and Supportive Activities, Good Health and Well Being, Adult, Blood Circulation, Female, Humans, Injury Severity Score, Male, Middle Aged, Multivariate Analysis, Resuscitation, Retrospective Studies, Shock, Hemorrhagic, Trauma Centers, Wounds and Injuries, Trauma resuscitation, Circulation first, Effects of intubation, Resuscitation in trauma, Trauma, Circulation, Hypovolemia and hypotension, Hypotension in trauma, Hypotension and resuscitation, AAST Multi-Institutional Trials Committee, Surgery, Clinical sciences
Abstract

BackgroundThe traditional sequence of trauma care: Airway, Breathing, Circulation (ABC) has been practiced for many years. It became the standard of care despite the lack of scientific evidence. We hypothesized that patients in hypovolemic shock would have comparable outcomes with initiation of bleeding treatment (transfusion) prior to intubation (CAB), compared to those patients treated with the traditional ABC sequence.MethodsThis study was sponsored by the American Association for the Surgery of Trauma multicenter trials committee. We performed a retrospective analysis of all patients that presented to trauma centers with presumptive hypovolemic shock indicated by pre-hospital or emergency department hypotension and need for intubation from January 1, 2014 to July 1, 2016. Data collected included demographics, timing of intubation, vital signs before and after intubation, timing of the blood transfusion initiation related to intubation, and outcomes.ResultsFrom 440 patients that met inclusion criteria, 245 (55.7%) received intravenous blood product resuscitation first (CAB), and 195 (44.3%) were intubated before any resuscitation was started (ABC). There was no difference in ISS, mechanism, or comorbidities. Those intubated prior to receiving transfusion had a lower GCS than those with transfusion initiation prior to intubation (ABC: 4, CAB:9, p = 0.005). Although mortality was high in both groups, there was no statistically significant difference (CAB 47% and ABC 50%). In multivariate analysis, initial SBP and initial GCS were the only independent predictors of death.ConclusionThe current study highlights that many trauma centers are already initiating circulation first prior to intubation when treating hypovolemic shock (CAB), even in patients with a low GCS. This practice was not associated with an increased mortality. Further prospective investigation is warranted.Trial registrationIRB approval number: HM20006627. Retrospective trial not registered.

Published
2018

6. WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections

Author

Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Agastra, Ervis, Abu-Zidan, Fikri M., Abbas, Ashraf El Sayed, Ansaloni, Luca, Adesunkanmi, Abdulrashid Kayode, Augustin, Goran, Bala, Miklosh, Baraket, Oussama, Biffl, Walter L., Ceresoli, Marco, Cerutti, Elisabetta, Chiara, Osvaldo, Cicuttin, Enrico, Chiarugi, Massimo, Coimbra, Raul, Corsi, Daniela, Cortese, Francesco, Cui, Yunfeng, Damaskos, Dimitris, de’Angelis, Nicola, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, de Jonge, Stijn W., Di Bella, Stefano, Di Saverio, Salomone, Duane, Therese M., Fugazzola, Paola, Galante, Joseph M., Ghnnam, Wagih, Gkiokas, George, Gomes, Carlos Augusto, Griffiths, Ewen A., Hardcastle, Timothy C., Hecker, Andreas, Herzog, Torsten, Karamarkovic, Aleksandar, Khokha, Vladimir, Kim, Peter K., Kim, Jae Il, Kirkpatrick, Andrew W., Kong, Victor, Koshy, Renol M., Inaba, Kenji, Isik, Arda, Ivatury, Rao, Labricciosa, Francesco M., Lee, Yeong Yeh, Leppäniemi, Ari, Litvin, Andrey, Luppi, Davide, Maier, Ronald V., Marinis, Athanasios, Marwah, Sanjay, Mesina, Cristian, Moore, Ernest E., Moore, Frederick A., Negoi, Ionut, Olaoye, Iyiade, Ordoñez, Carlos A., Ouadii, Mouaqit, Peitzman, Andrew B., Perrone, Gennaro, Pintar, Tadeja, Pipitone, Giuseppe, Podda, Mauro, Raşa, Kemal, Ribeiro, Julival, Rodrigues, Gabriel, Rubio-Perez, Ines, Sall, Ibrahima, Sato, Norio, Sawyer, Robert G., Shelat, Vishal G., Sugrue, Michael, Tarasconi, Antonio, Tolonen, Matti, Viaggi, Bruno, Celotti, Andrea, Casella, Claudio, Pagani, Leonardo, Dhingra, Sameer, Baiocchi, Gian Luca, and Catena, Fausto

Published
2022
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7. How to Use Antibiotics in Critically Ill Patients with Sepsis and Septic Shock

Author

Collom, Morgan, Duane, Therese M., Coccolini, Federico, Series Editor, Coimbra, Raul, Series Editor, Kirkpatrick, Andrew W., Series Editor, Di Saverio, Salomone, Series Editor, Ansaloni, Luca, Editorial Board Member, Balogh, Zsolt, Editorial Board Member, Biffl, Walt, Editorial Board Member, Catena, Fausto, Editorial Board Member, Davis, Kimberly, Editorial Board Member, Ferrada, Paula, Editorial Board Member, Fraga, Gustavo, Editorial Board Member, Ivatury, Rao, Editorial Board Member, Kluger, Yoram, Editorial Board Member, Leppaniemi, Ari, Editorial Board Member, Maier, Ron, Editorial Board Member, Moore, Ernest E., Editorial Board Member, Napolitano, Lena, Editorial Board Member, Peitzman, Andrew, Editorial Board Member, Reilly, Patrick, Editorial Board Member, Rizoli, Sandro, Editorial Board Member, Sakakushev, Boris, Editorial Board Member, Sartelli, Massimo, Editorial Board Member, Scalea, Thomas, Editorial Board Member, Spain, David, Editorial Board Member, Stahel, Philip, Editorial Board Member, Sugrue, Michael, Editorial Board Member, Velmahos, George, Editorial Board Member, Weber, Dieter, Editorial Board Member, Pagani, Leonardo, editor, and Rasa, Kemal, editor

Published
2021
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8. Expanding the scope of quality measurement in surgery to include nonoperative care

Author

Wandling, Michael W, Ko, Clifford Y, Bankey, Paul E, Cribari, Chris, Cryer, H Gill, Diaz, Jose J, Duane, Therese M, Hameed, S Morad, Hutter, Matthew M, Metzler, Michael H, Regner, Justin L, Reilly, Patrick M, Reines, H David, Sperry, Jason L, Staudenmayer, Kristan L, Utter, Garth H, Crandall, Marie L, Bilimoria, Karl Y, and Nathens, Avery B

Subjects
Patient Safety, 8.1 Organisation and delivery of services, Health and social care services research, Management of diseases and conditions, 7.3 Management and decision making, Appendicitis, Benchmarking, Cholecystitis, Emergency Medicine, Female, General Surgery, Humans, Intestinal Obstruction, Intestine, Small, Male, Pilot Projects, Quality Improvement, Emergency general surgery, surgical quality assessment, nonoperative management, Cardiorespiratory Medicine and Haematology, Clinical Sciences, Nursing, Emergency & Critical Care Medicine
Abstract

Patients managed non-operatively have been excluded from risk-adjusted benchmarking programs, including the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP). Consequently, optimal performance evaluation is not possible for specialties like emergency general surgery (EGS) where non-operative management is common. We developed a multi-institutional EGS clinical data registry within ACS NSQIP that includes patients managed non-operatively to evaluate variability in non-operative care across hospitals and identify gaps in performance assessment that occur when only operative cases are considered.Using ACS NSQIP infrastructure and methodology, surgical consultations for acute appendicitis, acute cholecystitis, and small bowel obstruction (SBO) were sampled at 13 hospitals that volunteered to participate in the EGS clinical data registry. Standard NSQIP variables and 16 EGS-specific variables were abstracted with 30-day follow-up. To determine the influence of complications in non-operative patients, rates of adverse outcomes were identified and hospitals were ranked by performance with and then without including non-operative cases.2,091 patients with EGS diagnoses were included, 46.6% with appendicitis, 24.3% with cholecystitis, and 29.1% with SBO. The overall rate of non-operative management was 27.4%, 6.6% for appendicitis, 16.5% for cholecystitis, and 69.9% for SBO. Despite comprising only 27.4% of patients in the EGS Pilot, non-operative management accounted for 67.7% of deaths, 34.3% of serious morbidities, and 41.8% of hospital readmissions. After adjusting for patient characteristics and hospital diagnosis mix, addition of non-operative management to hospital performance assessment resulted in 12 of 13 hospitals changing performance rank, with 4 hospitals changing by 3 or more positions.This study identifies a gap in performance evaluation when non-operative patients are excluded from surgical quality assessment and demonstrates the feasibility of incorporating non-operative care into existing surgical quality initiatives. Broadening the scope of hospital performance assessment to include non-operative management creates an opportunity to improve the care of all surgical patients, not just those who have an operation.III, Prognostic and Epidemiological.

Published
2017

9. Longer-Duration Antimicrobial Therapy Does Not Prevent Treatment Failure in High-Risk Patients with Complicated Intra-Abdominal Infections

Author

Hassinger, Taryn E, Guidry, Christopher A, Rotstein, Ori D, Duane, Therese M, Evans, Heather L, Cook, Charles H, O'Neill, Patrick J, Mazuski, John E, Askari, Reza, Napolitano, Lena M, Namias, Nicholas, Miller, Preston R, Dellinger, E Patchen, Coimbra, Raul, Cocanour, Christine S, Banton, Kaysie L, Cuschieri, Joseph, Popovsky, Kimberley, and Sawyer, Robert G

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Clinical Research, Infectious Diseases, Clinical Trials and Supportive Activities, Prevention, Patient Safety, Antimicrobial Resistance, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, Infection, Good Health and Well Being, Adult, Aged, Anti-Infective Agents, Female, Humans, Intraabdominal Infections, Male, Middle Aged, Retrospective Studies, Risk Factors, Time Factors, Treatment Failure, Surgery, Clinical sciences
Abstract

BackgroundRecent studies have suggested the length of treatment of intra-abdominal infections (IAIs) can be shortened without detrimental effects on patient outcomes. However, data from high-risk patient populations are lacking. We hypothesized that patients at high risk for treatment failure will benefit from a longer course of antimicrobial therapy.MethodsPatients enrolled in the Study to Optimize Peritoneal Infection Therapy (STOP-IT) trial were evaluated retrospectively to identify risk factors associated with treatment failure, which was defined as the composite outcome of recurrent IAI, surgical site infection, or death. Variables were considered risk factors if there was a positive statistical association with treatment failure. Patients were then stratified according to the presence and number of these risk factors. Univariable analyses were performed using the Kruskal-Wallis, χ2, and Fisher exact tests. Logistic regression controlling for risk factors and original randomization group, either a fixed four-day antimicrobial regimen (experimental) or a longer course based on clinical response (control), also was performed.ResultsWe identified corticosteroid use, Acute Physiology and Chronic Health Evaluation II score ≥5, hospital-acquired infection, or a colonic source of IAI as risk factors associated with treatment failure. Of the 517 patients enrolled, 263 (50.9%) had one or two risk factors and 16 (3.1%) had three or four risk factors. The rate of treatment failure rose as the number of risk factors increased. When controlling for randomization group, the presence and number of risk factors were independently associated with treatment failure, but the duration of antimicrobial therapy was not.ConclusionsWe were able to identify patients at high risk for treatment failure in the STOP-IT trial. Such patients did not benefit from a longer course of antibiotic administration. Further study is needed to determine the optimum duration of antimicrobial therapy in high-risk patients.

Published
2017

12. WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections

Author

Sartelli, Massimo, Coccolini, Federico, Kluger, Yoram, Agastra, Ervis, Abu-Zidan, Fikri M., Abbas, Ashraf El Sayed, Ansaloni, Luca, Adesunkanmi, Abdulrashid Kayode, Atanasov, Boyko, Augustin, Goran, Bala, Miklosh, Baraket, Oussama, Baral, Suman, Biffl, Walter L., Boermeester, Marja A., Ceresoli, Marco, Cerutti, Elisabetta, Chiara, Osvaldo, Cicuttin, Enrico, Chiarugi, Massimo, Coimbra, Raul, Colak, Elif, Corsi, Daniela, Cortese, Francesco, Cui, Yunfeng, Damaskos, Dimitris, de’ Angelis, Nicola, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, de Jonge, Stijn W., Dhingra, Sameer, Di Bella, Stefano, Di Marzo, Francesco, Di Saverio, Salomone, Dogjani, Agron, Duane, Therese M., Enani, Mushira Abdulaziz, Fugazzola, Paola, Galante, Joseph M., Gachabayov, Mahir, Ghnnam, Wagih, Gkiokas, George, Gomes, Carlos Augusto, Griffiths, Ewen A., Hardcastle, Timothy C., Hecker, Andreas, Herzog, Torsten, Kabir, Syed Mohammad Umar, Karamarkovic, Aleksandar, Khokha, Vladimir, Kim, Peter K., Kim, Jae Il, Kirkpatrick, Andrew W., Kong, Victor, Koshy, Renol M., Kryvoruchko, Igor A., Inaba, Kenji, Isik, Arda, Iskandar, Katia, Ivatury, Rao, Labricciosa, Francesco M., Lee, Yeong Yeh, Leppäniemi, Ari, Litvin, Andrey, Luppi, Davide, Machain, Gustavo M., Maier, Ronald V., Marinis, Athanasios, Marmorale, Cristina, Marwah, Sanjay, Mesina, Cristian, Moore, Ernest E., Moore, Frederick A., Negoi, Ionut, Olaoye, Iyiade, Ordoñez, Carlos A., Ouadii, Mouaqit, Peitzman, Andrew B., Perrone, Gennaro, Pikoulis, Manos, Pintar, Tadeja, Pipitone, Giuseppe, Podda, Mauro, Raşa, Kemal, Ribeiro, Julival, Rodrigues, Gabriel, Rubio-Perez, Ines, Sall, Ibrahima, Sato, Norio, Sawyer, Robert G., Segovia Lohse, Helmut, Sganga, Gabriele, Shelat, Vishal G., Stephens, Ian, Sugrue, Michael, Tarasconi, Antonio, Tochie, Joel Noutakdie, Tolonen, Matti, Tomadze, Gia, Ulrych, Jan, Vereczkei, Andras, Viaggi, Bruno, Gurioli, Chiara, Casella, Claudio, Pagani, Leonardo, Baiocchi, Gian Luca, and Catena, Fausto

Published
2021
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13. Trial of Short-Course Antimicrobial Therapy for Intraabdominal Infection

Author

Sawyer, Robert G, Claridge, Jeffrey A, Nathens, Avery B, Rotstein, Ori D, Duane, Therese M, Evans, Heather L, Cook, Charles H, O’Neill, Patrick J, Mazuski, John E, Askari, Reza, Wilson, Mark A, Napolitano, Lena M, Namias, Nicholas, Miller, Preston R, Dellinger, E Patchen, Watson, Christopher M, Coimbra, Raul, Dent, Daniel L, Lowry, Stephen F, Cocanour, Christine S, West, Michaela A, Banton, Kaysie L, Cheadle, William G, Lipsett, Pamela A, Guidry, Christopher A, and Popovsky, Kimberley

Subjects
Prevention, Infectious Diseases, Infection, Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents, Appendicitis, Drug Administration Schedule, Female, Fever, Humans, Intraabdominal Infections, Kaplan-Meier Estimate, Leukocytosis, Male, Medication Adherence, Middle Aged, Peritonitis, Recurrence, Sepsis, Surgical Wound Infection, Young Adult, STOP-IT Trial Investigators, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundThe successful treatment of intraabdominal infection requires a combination of anatomical source control and antibiotics. The appropriate duration of antimicrobial therapy remains unclear.MethodsWe randomly assigned 518 patients with complicated intraabdominal infection and adequate source control to receive antibiotics until 2 days after the resolution of fever, leukocytosis, and ileus, with a maximum of 10 days of therapy (control group), or to receive a fixed course of antibiotics (experimental group) for 4±1 calendar days. The primary outcome was a composite of surgical-site infection, recurrent intraabdominal infection, or death within 30 days after the index source-control procedure, according to treatment group. Secondary outcomes included the duration of therapy and rates of subsequent infections.ResultsSurgical-site infection, recurrent intraabdominal infection, or death occurred in 56 of 257 patients in the experimental group (21.8%), as compared with 58 of 260 patients in the control group (22.3%) (absolute difference, -0.5 percentage point; 95% confidence interval [CI], -7.0 to 8.0; P=0.92). The median duration of antibiotic therapy was 4.0 days (interquartile range, 4.0 to 5.0) in the experimental group, as compared with 8.0 days (interquartile range, 5.0 to 10.0) in the control group (absolute difference, -4.0 days; 95% CI, -4.7 to -3.3; P

Published
2015

21. 2020 update of the WSES guidelines for the management of acute colonic diverticulitis in the emergency setting

Author

Sartelli, Massimo, Weber, Dieter G., Kluger, Yoram, Ansaloni, Luca, Coccolini, Federico, Abu-Zidan, Fikri, Augustin, Goran, Ben-Ishay, Offir, Biffl, Walter L., Bouliaris, Konstantinos, Catena, Rodolfo, Ceresoli, Marco, Chiara, Osvaldo, Chiarugi, Massimo, Coimbra, Raul, Cortese, Francesco, Cui, Yunfeng, Damaskos, Dimitris, de’ Angelis, Gian Luigi, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Di Marzo, Francesco, Di Saverio, Salomone, Duane, Therese M., Faro, Mario Paulo, Fraga, Gustavo P., Gkiokas, George, Gomes, Carlos Augusto, Hardcastle, Timothy C., Hecker, Andreas, Karamarkovic, Aleksandar, Kashuk, Jeffry, Khokha, Vladimir, Kirkpatrick, Andrew W., Kok, Kenneth Y. Y., Inaba, Kenji, Isik, Arda, Labricciosa, Francesco M., Latifi, Rifat, Leppäniemi, Ari, Litvin, Andrey, Mazuski, John E., Maier, Ronald V., Marwah, Sanjay, McFarlane, Michael, Moore, Ernest E., Moore, Frederick A., Negoi, Ionut, Pagani, Leonardo, Rasa, Kemal, Rubio-Perez, Ines, Sakakushev, Boris, Sato, Norio, Sganga, Gabriele, Siquini, Walter, Tarasconi, Antonio, Tolonen, Matti, Ulrych, Jan, Zachariah, Sannop K., and Catena, Fausto

Published
2020
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24. Patients with Complicated Intra-Abdominal Infection Presenting with Sepsis Do Not Require Longer Duration of Antimicrobial Therapy

Author

Rattan, Rishi, Allen, Casey J., Sawyer, Robert G., Askari, Reza, Banton, Kaysie L., Claridge, Jeffrey A., Cocanour, Christine S., Coimbra, Raul, Cook, Charles H., Cuschieri, Joseph, Dellinger, E. Patchen, Duane, Therese M., Evans, Heather L., Lipsett, Pamela A., Mazuski, John E., Miller, Preston R., O’Neill, Patrick J., Rotstein, Ori D., and Namias, Nicholas

Published
2016
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25. The EGS grading scale for skin and soft-tissue infections is predictive of poor outcomes: a multicenter validation study

Author

Savage, Stephanie A., Li, Shi Wen, Utter, Garth H., Cox, Jessica A., Wydo, Salina M., Cahill, Kevin, Sarani, Babak, Holzmacher, Jeremy, Duane, Therese M., Gandhi, Rajesh R., Zielinski, Martin D., Ray-Zack, Mohamed, Tierney, Joshua, Chapin, Trinette, Murphy, Patrick B., Vogt, Kelly N., Schroeppel, Thomas J., Callaghan, Emma, Kobayashi, Leslie, Coimbra, Raul, Schuster, Kevin M., Gillaspie, Devin, Timsina, Lava, Louis, Alvancin, and Crandall, Marie

Published
2019
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33. The American Association for the Surgery of Trauma Severity Grade is valid and generalizable in adhesive small bowel obstruction

Author

Hernandez, Matthew C., Haddad, Nadeem N., Cullinane, Daniel C., Yeh, D. Dante, Wydo, Salina, Inaba, Kenji, Duane, Therese M., Pakula, Andrea, Skinner, Ruby, Rodriguez, Carlos J., Dunn, Julie, Sams, Valerie G., Zielinski, Martin D., Choudhry, Asad, Turay, David, Yune, Ji-Ming, Watras, Jill, Widom, Kenneth A., Cull, John, Toschlog, Eric A., and Graybill, John C.

Published
2018
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35. Diaphragm

Author

Aboutanos, Michel B., Duane, Therèse M., Malhotra, Ajai K., Ivatury, Rao R., Britt, L. D., editor, Trunkey, Donald D., editor, and Feliciano, David V., editor

Published
2007
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36. Knowledge, awareness, and attitude towards infection prevention and management among surgeons: identifying the surgeon champion

Author

Sartelli, Massimo, Kluger, Yoram, Ansaloni, Luca, Coccolini, Federico, Baiocchi, Gian Luca, Hardcastle, Timothy C., Moore, Ernest E., May, Addison K., Itani, Kamal M. F., Fry, Donald E., Boermeester, Marja A., Guirao, Xavier, Napolitano, Lena, Sawyer, Robert G., Rasa, Kemal, Abu-Zidan, Fikri M., Adesunkanmi, Abdulrashid K., Atanasov, Boyko, Augustin, Goran, Bala, Miklosh, Cainzos, Miguel A., Chichom-Mefire, Alain, Cortese, Francesco, Damaskos, Dimitris, Delibegovic, Samir, Demetrashvili, Zaza, De Simone, Belinda, Duane, Therese M., Ghnnam, Wagih, Gkiokas, George, Gomes, Carlos A., Hecker, Andreas, Karamarkovic, Aleksandar, Kenig, Jakub, Khokha, Vladimir, Kong, Victor, Isik, Arda, Leppäniemi, Ari, Litvin, Andrey, Lostoridis, Eftychios, Machain, Gustavo M., Marwah, Sanjay, McFarlane, Michael, Mesina, Cristian, Negoi, Ionut, Olaoye, Iyiade, Pintar, Tadeja, Pupelis, Guntars, Rems, Miran, Rubio-Perez, Ines, Sakakushev, Boris, Segovia-Lohse, Helmut, Siribumrungwong, Boonying, Talving, Peep, Ulrych, Jan, Vereczkei, András G., Labricciosa, Francesco M., and Catena, Fausto

Published
2018
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39. contributors

Author

AbdelFattah, Kareem R., primary, Aboutanos, Michel B., additional, Aliperti, Louis A., additional, Anderson, John T., additional, Anjaria, Devashish J., additional, Asensio, Juan A., additional, Askari, Morad, additional, Bailey, Jeffrey A., additional, Balters, Marcus, additional, Barbosa, Ron, additional, Barie, Philip S., additional, Bedrick, Edward J., additional, Berne, John D., additional, Berry, Stepheny D., additional, Bertelotti, Robert, additional, Bhatia, Pulkesh, additional, Biffl, Walter L., additional, Biggerstaff, Brian, additional, Bini, John K., additional, Blaisdell, F. William, additional, Bozeman, Matthew C., additional, Brandes, Steven B., additional, Brasel, Karen J., additional, Braslow, Benjamin M., additional, Britt, L.D., additional, Brundage, Susan I., additional, Brush, Thomas P., additional, Burlew, Clay Cothren, additional, Marie Byers, Patricia, additional, Caban, Kim M., additional, Cannon, Jeremy, additional, Cantie, Shawn M., additional, Esparragon, José Ceballos, additional, Champion, Howard R., additional, Chandler, Benjamin, additional, Chang, David C., additional, Cheung, Steven, additional, Chiu, William C., additional, Christmas, A. Britton, additional, Ciesla, David J., additional, Cioffi, William G., additional, Cocanour, Christine S., additional, Cohen, Mitchell J., additional, Coimbra, Raul, additional, Collister, Peter, additional, Cornwell, Edward E., additional, Cox, Thomas B., additional, Croce, Martin A., additional, Danton, Gary H., additional, Davis, Kimberly A., additional, Degiannis, Elias, additional, Deitch, Edwin A., additional, Denney, Richard, additional, Dente, Christopher J., additional, Desai, Urmen, additional, Dicker, Rochelle A., additional, Diebel, Lawrence N., additional, Dimitryi, Karev, additional, Doben, Andrew R., additional, Doucet, Jay, additional, Duane, Therese M., additional, DuBose, Joe, additional, Dubov, Wayne, additional, Duchesne, Juan C., additional, Dudrick, Stanley J., additional, Durham, Rodney, additional, Durso, Anthony M., additional, Eachempati, Soumitra R., additional, Eastridge, Colonel (Ret.) Brian, additional, Ebadat, Aileen, additional, Efron, David T., additional, Elster, Eric, additional, Englehart, Michael, additional, Esposito, Thomas J., additional, Estebanez, Glyn, additional, Evans, Susan, additional, Fakhry, Samir M., additional, Falvo, Anthony, additional, Feliciano, David V., additional, Fernández, Luis G., additional, Fink, Mitchell, additional, Flint, Lewis M., additional, Fry, Donald E., additional, Fujita, Takashi, additional, Galante, Joseph M., additional, Gamelli, Richard L., additional, García-Núñez, Luis Manuel, additional, Gentilello, Larry M., additional, Gilani, Ramyar, additional, Glance, Laurent G., additional, Gonzalez, Nestor R., additional, Grabo, Daniel J., additional, Gracia, Gerald J., additional, Gracias, Vincente H., additional, Gross, Kirby R., additional, Gross, Ronald I., additional, Guidry, Chrissy, additional, Gunter, Oliver L., additional, Gutmann, Joseph M., additional, Hale, Erin, additional, Hameed, S. Morad, additional, Hartmann, Molly, additional, Hauser, Carl, additional, Henry, Sharon, additional, Horst, Mathilda, additional, Hoschander, Ari, additional, Houin, Herman P., additional, Hoyt, David, additional, Huston, Jared M., additional, Ipaktchi, Kyros, additional, Joseph, D’Andrea, additional, Jurkovich, Gregory J., additional, Kalandiak, Steven, additional, Karmy-Jones, Riyad, additional, Khoo, Larry T., additional, Kiraly, Laszlo, additional, Kirton, Orlando C., additional, Ksycki, Michael, additional, Kunac, Anastasia, additional, Laeeq, Kulsoom, additional, Ledgerwood, Anna M., additional, Lemelman, Benjamin T., additional, Leppäniemi, Ari, additional, Livingston, David H., additional, Loden, Jason, additional, Lombardo, Gary, additional, Loukas, Andrew, additional, Lucas, Charles E., additional, Luchette, Fred A., additional, Mabry, Charles D., additional, Mackersie, Robert C., additional, Maggio, Paul M., additional, Magnotti, Louis J., additional, Mah, John W., additional, Malhotra, Ajai K., additional, Malinoski, Darren, additional, Maloley-Lewis, Brittney J., additional, Marini, Corrado Paolo, additional, Martin, Colonel Matthew J., additional, Mason, Leonard, additional, Mattox, Kenneth L., additional, Maull, Kimball, additional, Mayberry, John C., additional, Mazzini, Federico N., additional, McFarren, Christopher, additional, McSwain, Norman E., additional, Meallet, Mario A., additional, Meredith, J. Wayne, additional, Michetti, Christopher P., additional, Miller, Keith R., additional, Miller, Preston R., additional, Miller, Richard S., additional, Minei, Joseph P., additional, Mir, Haaris, additional, Mitchell, Frank L., additional, Mohr, Alicia M., additional, Moore, Ernest E., additional, Mosenthal, Anne C., additional, Munera, Felipa, additional, Murdock, Alan D., additional, Nabri, Mamoun, additional, Napolitano, Lena M., additional, Nash, Nicholas A., additional, Norwood, Scott H., additional, Oeltjen, John, additional, Okwuosa, Chris, additional, Osler, Turner M., additional, Osmolak, Angela, additional, Otomo, Yasuhiro, additional, Owens, Patrick, additional, Owings, John T., additional, Pachter, H. Leon, additional, Palange, David, additional, Panthaki, Zubin Jal, additional, Parikh, Manish S., additional, Pasquale, Michael D., additional, Peitzman, Andrew B., additional, Perez-Alonso, Alejandro, additional, Perkins, Christopher H., additional, Person, Austin, additional, Petrone, Patrizio, additional, Pharaon, K. Shad, additional, Philp, Allan S., additional, Pierre, Edgar J., additional, Piper, Greta L., additional, Plani, Frank, additional, Polanco, Patricio, additional, Policastro, Anthony, additional, Powell, Nathan J., additional, Pretorius, Riaan, additional, Propper, Brandon, additional, Pust, G. Daniel, additional, Putty, Bradley S., additional, Puyana, Juan Carlos, additional, Quinnan, Stephen M., additional, Quintana, David J., additional, Reed, R. Lawrence, additional, Reiser, Bibiana J., additional, Rhee, Peter, additional, Rhodes, Michael, additional, Rich, Norman M., additional, Richardson, J. David, additional, Richart, Charles M., additional, Rivas, Luis A., additional, Roberts, Jennifer C., additional, Rodríguez, Aurelio, additional, Rodríguez, Jorge L., additional, Rodriguez-García, Erwin, additional, Roeder, Rosaine, additional, Rojas-Tirado, David, additional, Rotondo, Michael F., additional, Rowell, Susan, additional, Rubano, Jerry A., additional, Rubiano, Andrés M., additional, Rushing, Amy, additional, Sade, Irony C., additional, Salgado, Christopher, additional, Salim, Ali, additional, Salliant, Noelle, additional, Salsamendi, Jason, additional, Sampson, James B., additional, Sanchez, Juan A., additional, Sánchez Maldonado, William, additional, Scalea, Thomas M., additional, Schecter, William P., additional, Schipper, Paul, additional, Schreiber, Martin, additional, Schulz, John T., additional, Schwab, C. William, additional, Serio, Stephen, additional, Shah, Parth, additional, Shapiro, Marc J., additional, Shatz, David, additional, Shetty, Shreya, additional, Shiroff, Adam M., additional, Sifri, Ziad C., additional, Sing, Ronald, additional, Sisley, Amy C., additional, Smith, R. Stephen, additional, Smith-Singares, Eduardo, additional, Spain, David A., additional, Spoerke, Nicholas, additional, Srinivasan, Ananth, additional, Stein, Deborah M., additional, Stirparo, Joseph J., additional, Stuke, Lance E., additional, Sukumar, Mithran, additional, Sundaram, Abhishek, additional, Svetanoff, Wendy Jo, additional, Swan, Kenneth G., additional, Tashjian, Vartan S., additional, Templin, Thomas, additional, Thal, Erwin, additional, Thaller, Seth R., additional, Tiesi, Gregory, additional, Tieu, Brandon, additional, Tillou, Areti, additional, Tinkoff, Glen, additional, Tisherman, Samuel, additional, Todd, S. Rob, additional, Torgersen, Zachary, additional, Trafton, Peter G., additional, Traynham, Mark, additional, Scherer, L.R. Tres, additional, Trunkey, Donald D., additional, Tsai, Peter I., additional, Tuggle, David W., additional, Udekwu, Anthony M., additional, Valadka, Alex B., additional, VanDerHeyden, Nicole, additional, Varghese, Thomas K., additional, Wagner, Michel, additional, Wall, Matthew J., additional, Watkins, Anthony, additional, Weigelt, John, additional, Weireter, Leonard J., additional, Welling, David R., additional, White, Paul W., additional, Wiegand, Lucas R., additional, Wilkins, Harry E., additional, Wilson, Robert F., additional, Wisner, David H., additional, and Yeh, D. Dante, additional

Published
2016
Full Text
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40. WSES/GAIS/WSIS/SIS-E/AAST global clinical pathways for patients with skin and soft tissue infections

Author

Sartelli, Massimo Coccolini, Federico Kluger, Yoram Agastra, Ervis Abu-Zidan, Fikri M. Abbas, Ashraf El Sayed Ansaloni, Luca Adesunkanmi, Abdulrashid Kayode Augustin, Goran Bala, Miklosh Baraket, Oussama Biffl, Walter L. Ceresoli, Marco and Cerutti, Elisabetta Chiara, Osvaldo Cicuttin, Enrico and Chiarugi, Massimo Coimbra, Raul Corsi, Daniela Cortese, Francesco Cui, Yunfeng Damaskos, Dimitris de'Angelis, Nicola and Delibegovic, Samir Demetrashvili, Zaza De Simone, Belinda and de Jonge, Stijn W. Di Bella, Stefano Di Saverio, Salomone and Duane, Therese M. Fugazzola, Paola Galante, Joseph M. and Ghnnam, Wagih Gkiokas, George Gomes, Carlos Augusto and Griffiths, Ewen A. Hardcastle, Timothy C. Hecker, Andreas and Herzog, Torsten Karamarkovic, Aleksandar Khokha, Vladimir and Kim, Peter K. Kim, Jae Il Kirkpatrick, Andrew W. Kong, Victor Koshy, Renol M. Inaba, Kenji Isik, Arda Ivatury, Rao Labricciosa, Francesco M. Lee, Yeong Yeh Leppaniemi, Ari and Litvin, Andrey Luppi, Davide Maier, Ronald V. Marinis, Athanasios Marwah, Sanjay Mesina, Cristian Moore, Ernest E. and Moore, Frederick A. Negoi, Ionut Olaoye, Iyiade Ordonez, Carlos A. Ouadii, Mouaqit Peitzman, Andrew B. Perrone, Gennaro Pintar, Tadeja Pipitone, Giuseppe Podda, Mauro and Rasa, Kemal Ribeiro, Julival Rodrigues, Gabriel Rubio-Perez, Ines Sall, Ibrahima Sato, Norio Sawyer, Robert G. and Shelat, Vishal G. Sugrue, Michael Tarasconi, Antonio and Tolonen, Matti Viaggi, Bruno Celotti, Andrea Casella, Claudio Pagani, Leonardo Dhingra, Sameer Baiocchi, Gian Luca and Catena, Fausto

Abstract

Skin and soft-tissue infections (SSTIs) encompass a variety of pathological conditions that involve the skin and underlying subcutaneous tissue, fascia, or muscle, ranging from simple superficial infections to severe necrotizing infections. Together, the World Society of Emergency Surgery, the Global Alliance for Infections in Surgery, the Surgical Infection Society-Europe, The World Surgical Infection Society, and the American Association for the Surgery of Trauma have jointly completed an international multi-society document to promote global standards of care in SSTIs guiding clinicians by describing reasonable approaches to the management of SSTIs. An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting evidence was shared by an international task force with different clinical backgrounds.

Published
2022

42. The public health burden of geriatric trauma: Analysis of 2,688,008 hospitalizations from Centers for Medicare and Medicaid Services inpatient claims

Author

Fakhry, Samir M., primary, Shen, Yan, additional, Biswas, Saptarshi, additional, Duane, Therese M., additional, McBride, Katherine M., additional, Elkbuli, Adel, additional, Wyse, Ransom J., additional, Wilson, Nina Y., additional, Garland, Jeneva M., additional, Kurek, Stanley J., additional, Plurad, David S., additional, Banton, Kaysie L., additional, Fisher, Chris, additional, Gage, Alexis, additional, Hunt, Diane L.S., additional, Lieser, Mark J., additional, Shillinglaw, William R.C., additional, and Watts, Dorraine D., additional

Published
2022
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44. WSES/GAIS/SIS-E/WSIS/AAST global clinical pathways for patients with intra-abdominal infections

Author

Sartelli, Massimo Coccolini, Federico Kluger, Yoram Agastra, Ervis Abu-Zidan, Fikri M. Abbas, Ashraf El Sayed Ansaloni, Luca Adesunkanmi, Abdulrashid Kayode Atanasov, Boyko and Augustin, Goran Bala, Miklosh Baraket, Oussama Baral, Suman and Biffl, Walter L. Boermeester, Marja A. Ceresoli, Marco and Cerutti, Elisabetta Chiara, Osvaldo Cicuttin, Enrico and Chiarugi, Massimo Coimbra, Raul Colak, Elif Corsi, Daniela and Cortese, Francesco Cui, Yunfeng Damaskos, Dimitris and Angelis, Nicola De' Delibegovic, Samir Demetrashvili, Zaza and De Simone, Belinda de Jonge, Stijn W. Dhingra, Sameer Di Bella, Stefano Di Marzo, Francesco Di Saverio, Salomone and Dogjani, Agron Duane, Therese M. Enani, Mushira Abdulaziz and Fugazzola, Paola Galante, Joseph M. Gachabayov, Mahir and Ghnnam, Wagih Gkiokas, George Gomes, Carlos Augusto and Griffiths, Ewen A. Hardcastle, Timothy C. Hecker, Andreas and Herzog, Torsten Kabir, Syed Mohammad Umar Karamarkovic, Aleksandar Khokha, Vladimir Kim, Peter K. Il Kim, Jae and Kirkpatrick, Andrew W. Kong, Victor Koshy, Renol M. and Kryvoruchko, Igor A. Inaba, Kenji Isik, Arda Iskandar, Katia and Ivatury, Rao Labricciosa, Francesco M. Lee, Yeong Yeh and Leppaniemi, Ari Litvin, Andrey Luppi, Davide Machain, Gustavo M. Maier, V, Ronald Marinis, Athanasios Marmorale, Cristina Marwah, Sanjay Mesina, Cristian Moore, Ernest E. and Moore, Frederick A. Negoi, Ionut Olaoye, Iyiade Ordonez, Carlos A. Ouadii, Mouaqit Peitzman, Andrew B. Perrone, Gennaro Pikoulis, Manos Pintar, Tadeja Pipitone, Giuseppe and Podda, Mauro Rasa, Kemal Ribeiro, Julival Rodrigues, Gabriel Rubio-Perez, Ines Sall, Ibrahima Sato, Norio and Sawyer, Robert G. Lohse, Helmut Segovia Sganga, Gabriele and Shelat, Vishal G. Stephens, Ian Sugrue, Michael Tarasconi, Antonio Tochie, Joel Noutakdie Tolonen, Matti Tomadze, Gia and Ulrych, Jan Vereczkei, Andras Viaggi, Bruno Gurioli, Chiara Casella, Claudio Pagani, Leonardo Baiocchi, Gian Luca and Catena, Fausto

Subjects
embryonic structures
Abstract

Intra-abdominal infections (IAIs) are common surgical emergencies and have been reported as major contributors to non-trauma deaths in hospitals worldwide. The cornerstones of effective treatment of IAIs include early recognition, adequate source control, appropriate antimicrobial therapy, and prompt physiologic stabilization using a critical care environment, combined with an optimal surgical approach. Together, the World Society of Emergency Surgery (WSES), the Global Alliance for Infections in Surgery (GAIS), the Surgical Infection Society-Europe (SIS-E), the World Surgical Infection Society (WSIS), and the American Association for the Surgery of Trauma (AAST) have jointly completed an international multi-society document in order to facilitate clinical management of patients with IAIs worldwide building evidence-based clinical pathways for the most common IAIs. An extensive non-systematic review was conducted using the PubMed and MEDLINE databases, limited to the English language. The resulting information was shared by an international task force from 46 countries with different clinical backgrounds. The aim of the document is to promote global standards of care in IAIs providing guidance to clinicians by describing reasonable approaches to the management of IAIs.

Published
2021

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