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Upon repeating the experiments, the authors found that the number of equivalents needed to elicit a change in the absorption and emission spectra was higher than those originally reported in the manuscript, and the ratiometric response was lower. (e) absorbance and (f) fluorescence spectral changes of 1 (20 M) upon Na3PO4 titration, inset: (e) ratio of absorbance at 447 and 358 nm as a function of Pi concentration; (f) ratio of fluorescence intensity at 531 and 450 nm as a function of Pi concentration. gl We would like to replace the sentences "The absorption ratio (A427/A357) increased gradually from 0.04 to 1.64, and the fluorescence ratio (F532/F453) showed a sigmoid dependency on the Pi concentration, resulting in a 91-fold enhancement (Figure e,f, inset). This indicated a quantitative detection of Pi by fluorescence ratiometry in the 25 to 75 equivalent ranges." with " The absorption ratio (A427/A357) increased gradually from 0.062 to 0.819, and the fluorescence ratio (F532/F453) showed a sigmoid dependency on the Pi concentration, resulting in a 9-fold enhancement (Figure e,f, inset). [Extracted from the article]

A chemodosimeter was designed to function as a highly selective phosphate ion (Pi) sensor, showing a 91-fold ratiometric fluorescence enhancement. The probe successfully visualized exogenous and endogenous apyrase-catalyzed Pi generation and was the first probe able to trace the generation and enrichment of Pi through hemichannel closure in Sf9 cells. [ABSTRACT FROM AUTHOR]

Abstract: A 1,8-naphthyridine modified rhodamine B derivative (1) has been designed and synthesized. Compound 1 is the first 1,8-naphthyridine-modified rhodamine B sensor that can detect Cu2+ selectively with a dramatic color change from colorless to pink. The complex of 1 and Cu2+ was utilized as a chemosensing ensemble for cysteine (Cys), homocysteine (Hcy), and glutathione (GSH) detection, which showed highly sensitive and selective colorimetric response to Cys, Hcy, and GSH among the tested naturally occurring α-amino acids in EtOH-HEPES (0.02M, pH 7.4) (3:7, v/v) buffer solution. [Copyright &y& Elsevier]

A chemodosimeter was designed to function as a highly selective phosphate ion (Pi) sensor, showing a 91-fold ratiometric fluorescence enhancement. The probe successfully visualized exogenous and endogenous apyrase-catalyzed Pi generation and was the first probe able to trace the generation and enrichment of Pi through hemichannel closure in Sf9 cells. [ABSTRACT FROM AUTHOR]

While CKLF-like MARVEL transmembrane domain containing 6 (CMTM6)'s role in stabilizing PD-L1 and immune evasion within tumors is established, its expression in lung cancer tissue and adjacent macrophages remains uncertain. The study aimed to elucidate this ambiguity by investigating CMTM6's role in non-small cell lung cancer (NSCLC) prognosis. Employing immunohistochemical staining on 141 NSCLC and 110 adjacent normal lung tissue samples, CMTM6 expression was evaluated using the HSCORE system. Interestingly, NSCLC exhibited significantly higher CMTM6 levels (161.04±86.60) compared to normal tissues (71.20±45.10) ( p < 0.001), detected not only in cancer cells but also in macrophages, lymphocytes, and nearby bronchial epithelial cells. Stratifying patients by CMTM6 levels unveiled a correlation between heightened expression and poorer overall survival ( p = 0.003), alongside a link to tumor-infiltrating lymphocytes (TIL) ( p = 0.037), especially in cases with increased TIL. Multivariate analysis identified CMTM6 as an independent predictor of overall survival ( p = 0.009), implying that elevated CMTM6 expression in NSCLC might signify an adverse prognostic marker for patient outcomes., Competing Interests: Competing Interests: The authors have declared that no competing interest exists., (© The author(s).)

A chemodosimeter was designed to function as a highly selective phosphate ion (Pi ) sensor, showing a 91-fold ratiometric fluorescence enhancement. The probe successfully visualized exogenous and endogenous apyrase-catalyzed Pi generation and was the first probe able to trace the generation and enrichment of Pi through hemichannel closure in Sf9 cells., (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)