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28 results on '"Duan, Manman"'

6. Propranolol treatment for facial hemangioma in a patient with dandy-walker malformation and PHACE syndrome: A case report

Author

Duan, Manman, Zhang, Jingzhan, Xiang, Fang, Zulikere, Zhu, Xuee, Kang, Xiaojing, and Ding, Yuan

Subjects
DNA microarrays, Hemangioma -- Care and treatment, Vincristine, Health
Abstract

Byline: Manman. Duan, Jingzhan. Zhang, Fang. Xiang, Zulikere, Xuee. Zhu, Xiaojing. Kang, Yuan. Ding Sir, A 28-day-old male baby was admitted to our hospital for erythema and multiple masses were [...]

Published
2023

8. Sporophytic control of tapetal development and pollen fertility by a mitogen‐activated protein kinase cascade in rice.

Author

Zeng, Jianguo, Duan, Manman, Wang, Yiqing, Li, Guangtao, You, Yujing, Shi, Jie, Liu, Changhao, Zhang, Jinyang, Xu, Juan, Zhang, Shuqun, and Zhao, Jing

Subjects
*MALE sterility in plants, *MITOGEN-activated protein kinases, *ANTHER, *POLLEN, *FERTILITY, *APOPTOSIS, *GENE regulatory networks
Abstract

Tapetum, the innermost layer of the anther wall, provides essential nutrients and materials for pollen development. Timely degradation of anther tapetal cells is a prerequisite for normal pollen development in flowering plants. Tapetal cells facilitate male gametogenesis by providing cellular contents after highly coordinated programmed cell death (PCD). Tapetal development is regulated by a transcriptional network. However, the signaling pathway(s) involved in this process are poorly understood. In this study, we report that a mitogen‐activated protein kinase (MAPK) cascade composed of OsYDA1/OsYDA2‐OsMKK4‐OsMPK6 plays an important role in tapetal development and male gametophyte fertility. Loss of function of this MAPK cascade leads to anther indehiscence, enlarged tapetum, and aborted pollen grains. Tapetal cells in osmkk4 and osmpk6 mutants exhibit an increased presence of lipid body‐like structures within the cytoplasm, which is accompanied by a delayed occurrence of PCD. Expression of a constitutively active version of OsMPK6 (CA‐OsMPK6) can rescue the pollen defects in osmkk4 mutants, confirming that OsMPK6 functions downstream of OsMKK4 in this pathway. Genetic crosses also demonstrated that the MAPK cascade sporophyticly regulates pollen development. Our study reveals a novel function of rice MAPK cascade in plant male reproductive biology. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Sub-chronic toxicity of broflanilide on the nervous system of zebrafish (Danio rerio)

Author

Wang, Kai, Qi, Zhiqiu, Duan, Manman, Zhang, Ru, and He, Lu

Subjects
Ecology, General Earth and Planetary Sciences, Ecology, Evolution, Behavior and Systematics, General Environmental Science
Abstract

The new insecticide broflanilide, which possesses high insecticidal activity against agricultural pests, acts on the γ-aminobutyric acid receptor in the insect nervous system. At present, few studies assessed its effect on the nervous system of zebrafish, especially its sub-chronic toxicity on the zebrafish brain. In this study, the sub-chronic toxicity of broflanilide on the zebrafish brain was assessed. After 21 days of exposure at 36.3 μg/L, broflanilide caused oxidative damage to the zebrafish brain, increased the levels of reactive oxygen species and malondialdehyde, and inhibited the activities of superoxide dismutase, catalase, and glutathione peroxidase. Overall, these changes result in brain cell apoptosis, and inhibited growth and development. Moreover, broflanilide affects the release of acetylcholinesterase, γ-aminobutyric acid, 5-hydroxy tryptamine, and dopamine as well as the expression of related genes in the brain, leading to abnormal zebrafish behaviour. These results corroborate the sub-chronic toxicity of broflanilide on zebrafish brain, which helps the further understanding of the potential environmental risk of broflanilide.

Published
2022
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19. Sub-chronic toxicity of broflanilide on the nervous system of zebrafish (Danio rerio).

Author

Wang, Kai, Qi, Zhiqiu, Duan, Manman, Zhang, Ru, and He, Lu

Subjects
INSECTICIDES, NERVOUS system, BRACHYDANIO, ZEBRA danio, GLUTATHIONE peroxidase, REACTIVE oxygen species, SUPEROXIDE dismutase, AGRICULTURAL pests
Abstract

The new insecticide broflanilide, which possesses high insecticidal activity against agricultural pests, acts on the γ-aminobutyric acid receptor in the insect nervous system. At present, few studies assessed its effect on the nervous system of zebrafish, especially its sub-chronic toxicity on the zebrafish brain. In this study, the sub-chronic toxicity of broflanilide on the zebrafish brain was assessed. After 21 days of exposure at 36.3 μg/L, broflanilide caused oxidative damage to the zebrafish brain, increased the levels of reactive oxygen species and malondialdehyde, and inhibited the activities of superoxide dismutase, catalase, and glutathione peroxidase. Overall, these changes result in brain cell apoptosis, and inhibited growth and development. Moreover, broflanilide affects the release of acetylcholinesterase, γ-aminobutyric acid, 5-hydroxy tryptamine, and dopamine as well as the expression of related genes in the brain, leading to abnormal zebrafish behaviour. These results corroborate the sub-chronic toxicity of broflanilide on zebrafish brain, which helps the further understanding of the potential environmental risk of broflanilide. [ABSTRACT FROM AUTHOR]

Published
2023
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