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500 results on '"Duan, Hongxia"'

36. A Recyclable Inorganic Lanthanide Cluster Catalyst for Chemoselective Aerobic Oxidation of Thiols.

Author

Wang, Lijun, Qin, Zixuan, Chen, Lingxia, Qin, Xinshu, Hou, Jiaman, Wang, Chao, Li, Xuan, Duan, Hongxia, Fang, Bing, Wang, Minlong, and An, Jie

Subjects
OXYGEN in water, ORGANIC synthesis, WASTE recycling, FUNCTIONAL groups, CHEMOSELECTIVITY
Abstract

Optimizing lanthanide catalyst performance with organic ligands often encounters significant challenges, including susceptibility to water or oxygen and complex synthesis pathways. To address these issues, our research focuses on developing inorganic lanthanide clusters with enhanced stability and functionality. In this study, we introduce the [Sm6O(OH)8(H2O)24]I8(H2O)8 cluster (Sm-OC) as a sustainable and efficient catalyst for the aerobic oxidation of thiols under heating conditions. The Sm-OC catalyst demonstrated remarkable stability, outstanding recyclability, and excellent chemoselectivity across a diverse range of functional groups in 38 different tests. Notably, it enables efficient unsymmetrical disulfide synthesis and prevents the formation of over-oxidized by-products, highlighting its superior performance. This Sm-OC catalyst provides a practical and robust tool for the precise construction of versatile disulfides, thus establishing a template for the broader use of lanthanide clusters in organic synthesis. [ABSTRACT FROM AUTHOR]

Published
2024
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38. Effect of Three Novel Thiazolidiones on the Development, Reproduction, and Trehalase Activity of Spodoptera frugiperda (Lepidoptera: Noctuidae).

Author

Yu, Liuhe, Zhong, Fan, Jiang, Xinyi, He, Biner, Fu, Haoyu, Liu, Xiangyu, Mao, Qixuan, Zhao, Ying, Wang, Shigui, Wu, Yan, Duan, Hongxia, and Tang, Bin

Subjects
FALL armyworm, NOCTUIDAE, LEPIDOPTERA, GENE expression, REPRODUCTION, INSECT physiology, LARVAE
Abstract

Spodoptera frugiperda was used to investigate its role as a trehalase inhibitor of three new thiothiazolidone compounds—6d, 6e, and 6f. The development and reproduction of S. frugiperda were investigated to evaluate the potential of these compounds as a novel pesticide for pest control. Compounds 6d, 6e, and 6f were injected into larvae and female pupae. Molecular changes in trehalose and chitin metabolism genes were monitored. Pupal trehalase activity, the female pupal emergence rate, ovarian development, and SfVg and SfVgR gene expression levels were assessed. The results revealed that all three compounds significantly inhibited trehalase activity in the larvae. The expression of TRE was significantly downregulated, and compounds 6d and 6f significantly downregulated the expression of TRE2. Treated larvae exhibited significantly decreased survival rates and a higher incidence of abnormalities. The egg production and hatching rates were markedly diminished by the inhibitors, and the ovaries displayed blackening and clumping. These compounds exhibit promise as eco-friendly insecticides, but further experiments are required to test their multifaceted capabilities. [ABSTRACT FROM AUTHOR]

Published
2024
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40. Dual-Specificity Inhibitor Targets Enzymes of the Trehalose Biosynthesis Pathway

Author

Chen, Yitong, primary, Tang, Liu, additional, Jiang, Zhiyang, additional, Wang, Shanshan, additional, Qi, Linlu, additional, Tian, Xiaolin, additional, Deng, Haiteng, additional, Kong, Zhiwei, additional, Gao, Wenqiang, additional, Zhang, Xiaokang, additional, Li, Saijie, additional, Chen, Meiqing, additional, Zhang, Xin, additional, Duan, Hongxia, additional, Yang, Jun, additional, Peng, You-Liang, additional, Wang, Dongli, additional, and Liu, Junfeng, additional

Published
2023
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47. A Cross-Cultural Study on Environmental Risk Perception and Educational Strategies: Implications for Environmental Education in China

Author

Duan, Hongxia and Fortner, Rosanne

Abstract

This cross-cultural study examined college students' environmental risk perception and their preference in terms of risk communication and educational strategies in China and the United States. The results indicated that the Chinese respondents were more concerned about environmental risk, and they perceived the environmental issues to be more harmful to health, to the environment, and to social economic development of the nation than did the American respondents. Both groups desired transparent communications in decision processes and would support educational strategies that foster behavior change for reduction of environmental risks. On the basis of the findings, the paper discusses the changes that would potentially improve non-formal and formal environmental education in China from the perspectives of program foci and approaches.

Published
2010

49. Selectivity of odorant-binding proteins from the southern house mosquito tested against physiologically relevant ligands

Author

Yin, Jiao, Choo, Young-Moo, Duan, Hongxia, and Leal, Walter S

Subjects
Biochemistry and Cell Biology, Medical Physiology, Biomedical and Clinical Sciences, Biological Sciences, Infectious Diseases, Vector-Borne Diseases, CguiOBP1, CguiOBP2, CguiOBP5, Culex quinquefasciatus, docking, CquiOBP1, CquiOBP2, CquiOBP5, Physiology, Psychology, Biochemistry and cell biology, Medical physiology
Abstract

As opposed to humans, insects rely heavily on an acute olfactory system for survival and reproduction. Two major types of olfactory proteins, namely, odorant-binding proteins (OBPs) and odorant receptors (ORs), may contribute to the selectivity and sensitivity of the insects' olfactory system. Here, we aimed at addressing the question whether OBPs highly enriched in the antennae of the southern house mosquito, Culex quinquefasciatus, contribute at least in part to the selective reception of physiologically relevant compounds. Using a fluorescence reporter and a panel of 34 compounds, including oviposition attractants, human-derived attractants, and repellents, we measured binding affinities of CquiOBP1, CquiOBP2, and CquiOBP5. Based on dissociation constants, we surmised that CquiOBP2 is a carrier for the oviposition attractant skatole, whereas CquiOBP1 and CquiOBP5 might transport the oviposition pheromone MOP, a human-derived attractant nonanal, and the insect repellent picardin. Binding of these three ligands to CquiOBP1 was further analyzed by examining the influence of pH on apparent affinity as well as by docking these three ligands into CquiOBP1. Our findings suggest that CquiOBP1 might discriminate MOP from nonanal/picaridin on the basis of the midpoint transition of a pH-dependence conformational change, and that MOP is better accommodated in the binding cavity than the other two ligands. These findings, along with previous experimental evidence suggesting that CquiOBP1 does not detect nonanal in vivo, suggest that OBP selectivity may not be clearly manifested in their dissociation constants.

Published
2015

50. Rational Design of Triazinone Derivatives with Low Bee Toxicity Based on the Binding Mechanism of Neonicotinoids to Apis mellifera

Author

Lu, Xingxing, Jiang, Zhiyang, Xu, Huan, Zhang, Xiaoming, Lin, Yufan, Pan, Shixiang, Zhang, Yimeng, Liu, Yan, Wang, Yinliang, Li, Xuesheng, Duan, Hongxia, Yang, Xinling, and Ling, Yun

Abstract

Bees, one of the most vital pollinators in the ecosystem and agriculture, are currently threatened by neonicotinoids. To explore the molecular mechanisms of neonicotinoid toxicity to bees, the different binding modes of imidacloprid, thiacloprid, and flupyradifurone with nicotinic acetylcholine receptor (nAChR) α1β1 and cytochrome P450 9Q3 (CYP9Q3) were studied using homology modeling and molecular dynamics simulations. These mechanisms provided a basis for the design of compounds with a potential low bee toxicity. Consequently, we designed and synthesized a series of triazinone derivatives and assessed their bioassays. Among them, compound 5anot only displayed substantially insecticidal activities against Aphis glycines(LC50= 4.40 mg/L) and Myzus persicae(LC50= 6.44 mg/L) but also had low toxicity to Apis mellifera. Two-electrode voltage clamp recordings further confirmed that compound 5ainteracted with the M. persicaenAChR α1 subunit but not with the A. melliferanAChR α1 subunit. This work provides a paradigm for applying molecular toxic mechanisms to the design of compounds with low bee toxicity, thereby aiding the future rational design of eco-friendly nicotinic insecticides.

Published
2024
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