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39 results on '"DuBois, P.C."'

1. Military camping impacts on vegetation and soils of the Ozark Plateau

Author

Trumbull, V.L., Dubois, P.C., Brozka, R.J., and Guyette, R.

Subjects
Missouri -- Environmental aspects, Soil stabilization -- Research, Forest litter -- Biodegradation, Soils -- Composition, Environmental issues
Abstract

A study of the woody vegetation and soils of 20-to-40-year-old military camp-sites in south-central Missouri revealed a smaller density, species richness of over- and understory plants, less tree litter, more bare ground, lower word stem density, higher soil bulk densities, lower total organic carbon in the soil and a reduced soil depth ranging from 28 to 61 cm.

Published
1994

2. Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

Author

Hunt, K.A., Smyth, D.J., Balschun, T., Ban, M., Mistry, V., Ahmad, T., Anand, V., Barrett, J.C., Bhaw-Rosun, L., Bockett, N.A., Brand, O.J., Brouwer, E., Concannon, P., Cooper, J.D., Dias, K.R.M., Diemen, C.C. van, Dubois, P.C., Edkins, S., Folster-Holst, R., Fransen, K., Glass, D.N., Heap, G.A.R., Hofmann, S., Huizinga, T.W.J., Hunt, S., Langford, C., Lee, J., Mansfield, J., Marrosu, M.G., Mathew, C.G., Mein, C.A., Muller-Quernheim, J., Nutland, S., Onengut-Gumuscu, S., Ouwehand, W., Pearce, K., Prescott, N.J., Posthumus, M.D., Potter, S., Rosati, G., Sambrook, J., Satsangi, J., Schreiber, S., Shtir, C., Simmonds, M.J., Sudman, M., Thompson, S.D., Toes, R., Trynka, G., Vyse, T.J., Walker, N.M., Weidinger, S., Zhernakova, A., Zoledziewska, M., Weersma, R.K., Gough, S.C.L., Sawcer, S., Wijmenga, C., Parkes, M., Cucca, F., Franke, A., Deloukas, P., Rich, S.S., Todd, J.A., Heel, D.A. van, Type 1 Diabet Genetics, UK Inflammatory Bowel Dis IBD, and Wellcome Trust Case

Published
2012

3. Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease

Author

Trynka, G., Hunt, K.A., Bockett, N.A., Romanos, J., Mistry, V., Szperl, A., Bakker, S.F., Bardella, M.T., Bhaw-Rosun, L., Castillejo, G., Concha, E. de la, Almeida, R.C. de, Dias, K.R., Diemen, C.C. van, Dubois, P.C., Duerr, R.H., Edkins, S., Franke, L., Fransen, K., Gutierrez, J., Heap, G.A., Hrdlickova, B., Hunt, S., Izurieta, L.P., Izzo, V., Joosten, L.A.B., Langford, C., Mazzilli, M.C., Mein, C.A., Midah, V., Mitrovic, M., Mora, B., Morelli, M., Nutland, S., Nunez, C., Onengut-Gumuscu, S., Pearce, K., Platteel, M., Polanco, I., Potter, S., Ribes-Koninckx, C., Ricano-Ponce, I., Rich, S.S., Rybak, A., Santiago, J.L., Senapati, S., Sood, A., Szajewska, H., Troncone, R., Varade, J., Wallace, C., Wolters, V.M., Zhernakova, A., Thelma, B.K., Cukrowska, B., Urcelay, E., Bilbao, J.R., Mearin, ML, Barisani, D., Barrett, J.C., Plagnol, V., Deloukas, P., Wijmenga, C., Heel, D.A. van, Trynka, G., Hunt, K.A., Bockett, N.A., Romanos, J., Mistry, V., Szperl, A., Bakker, S.F., Bardella, M.T., Bhaw-Rosun, L., Castillejo, G., Concha, E. de la, Almeida, R.C. de, Dias, K.R., Diemen, C.C. van, Dubois, P.C., Duerr, R.H., Edkins, S., Franke, L., Fransen, K., Gutierrez, J., Heap, G.A., Hrdlickova, B., Hunt, S., Izurieta, L.P., Izzo, V., Joosten, L.A.B., Langford, C., Mazzilli, M.C., Mein, C.A., Midah, V., Mitrovic, M., Mora, B., Morelli, M., Nutland, S., Nunez, C., Onengut-Gumuscu, S., Pearce, K., Platteel, M., Polanco, I., Potter, S., Ribes-Koninckx, C., Ricano-Ponce, I., Rich, S.S., Rybak, A., Santiago, J.L., Senapati, S., Sood, A., Szajewska, H., Troncone, R., Varade, J., Wallace, C., Wolters, V.M., Zhernakova, A., Thelma, B.K., Cukrowska, B., Urcelay, E., Bilbao, J.R., Mearin, ML, Barisani, D., Barrett, J.C., Plagnol, V., Deloukas, P., Wijmenga, C., and Heel, D.A. van

Abstract

Item does not contain fulltext, Using variants from the 1000 Genomes Project pilot European CEU dataset and data from additional resequencing studies, we densely genotyped 183 non-HLA risk loci previously associated with immune-mediated diseases in 12,041 individuals with celiac disease (cases) and 12,228 controls. We identified 13 new celiac disease risk loci reaching genome-wide significance, bringing the number of known loci (including the HLA locus) to 40. We found multiple independent association signals at over one-third of these loci, a finding that is attributable to a combination of common, low-frequency and rare genetic variants. Compared to previously available data such as those from HapMap3, our dense genotyping in a large sample collection provided a higher resolution of the pattern of linkage disequilibrium and suggested localization of many signals to finer scale regions. In particular, 29 of the 54 fine-mapped signals seemed to be localized to single genes and, in some instances, to gene regulatory elements. Altogether, we define the complex genetic architecture of the risk regions of and refine the risk signals for celiac disease, providing the next step toward uncovering the causal mechanisms of the disease.

Published
2011

4. Evolutionary and functional analysis of celiac risk loci reveals SH2B3 as a protective factor against bacterial infection.

Author

Zhernakova, A., Elbers, C.C., Ferwerda, B., Romanos, J., Trynka, G., Dubois, P.C., Kovel, C.G.F. de, Franke, L., Oosting, M., Barisani, D., Bardella, M.T., Joosten, L.A.B., Saavalainen, P., Heel, D.A. van, Catassi, C., Netea, M.G., Wijmenga, C., Zhernakova, A., Elbers, C.C., Ferwerda, B., Romanos, J., Trynka, G., Dubois, P.C., Kovel, C.G.F. de, Franke, L., Oosting, M., Barisani, D., Bardella, M.T., Joosten, L.A.B., Saavalainen, P., Heel, D.A. van, Catassi, C., Netea, M.G., and Wijmenga, C.

Abstract

Contains fulltext : 88653.pdf (publisher's version ) (Closed access), Celiac disease (CD) is an intolerance to dietary proteins of wheat, barley, and rye. CD may have substantial morbidity, yet it is quite common with a prevalence of 1%-2% in Western populations. It is not clear why the CD phenotype is so prevalent despite its negative effects on human health, especially because appropriate treatment in the form of a gluten-free diet has only been available since the 1950s, when dietary gluten was discovered to be the triggering factor. The high prevalence of CD might suggest that genes underlying this disease may have been favored by the process of natural selection. We assessed signatures of selection for ten confirmed CD-associated loci in several genome-wide data sets, comprising 8154 controls from four European populations and 195 individuals from a North African population, by studying haplotype lengths via the integrated haplotype score (iHS) method. Consistent signs of positive selection for CD-associated derived alleles were observed in three loci: IL12A, IL18RAP, and SH2B3. For the SH2B3 risk allele, we also show a difference in allele frequency distribution (Fst) between HapMap phase II populations. Functional investigation of the effect of the SH2B3 genotype in response to lipopolysaccharide and muramyl dipeptide revealed that carriers of the SH2B3 rs3184504*A risk allele showed stronger activation of the NOD2 recognition pathway. This suggests that SH2B3 plays a role in protection against bacteria infection, and it provides a possible explanation for the selective sweep on SH2B3, which occurred sometime between 1200 and 1700 years ago.

Published
2010

11. The International Trader

Author

DuBois, P.C.

Subjects
Performance -- Marketing, Commerce -- International aspects, Business, general
Published
1983

12. New Hope for a Channel Tunnel?

Author

DuBois, P.C.

Subjects
France -- Transportation, United Kingdom -- Transportation, Travel, Business, general
Published
1982

13. Stockholm Hits All-Time Highs on Strong Earnings

Author

DuBois, P.C.

Subjects
Sweden -- Securities, Stock-exchange -- Sweden, Business, general
Abstract

Sweden's stock market has been hitting record heights in 1983. Its rally has been fueled by the good earnings of muntinationals like Electrolux and Volvo. Foreign investment, tax incentives, and a major devaluation of the country's currency have also contributed to the rally. Analyses of several major Swedish stocks are included.

Published
1983

14. The International Trader

Author

DuBois, P.C.

Subjects
Banking industry -- United Kingdom, Banking industry -- Economic policy, Business, general
Published
1982

15. Erin Go Boom. Oil Find Keeps Boosting Dublin Market

Author

DuBois, P.C.

Subjects
Ireland -- Securities, Petroleum -- Ireland, Business, general
Abstract

The discovery of oil off the coast of Ireland has led to a boom in the Irish stock market. The oil field has been estimated to be of huge proportions. One of the owners of the field, an Irish firm called Atlantic Resources, has had a history of very bad luck. The discovery may have important consequences for Ireland, which imports most of its oil.

Published
1983

23. U.S. Pension Money Pours Overseas

Author

DuBois, P.C.

Subjects
Pensions -- United States, Investments -- International aspects, Business, general
Published
1983

25. The International Trader

Author

DuBois, P.C.

Subjects
Bull market -- New Zealand, Interest rates -- Economic aspects, Business, general
Abstract

There are four stock exchanges in New Zealand. In the last eighteen months shareholding moved away from institutions to individuals. A long rally has been underway in 1983.

Published
1984

27. Trouble in London

Author

DuBois, P.C.

Subjects
United Kingdom -- Economic aspects, Business, general
Published
1983

28. Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

Author

Hunt, K. A., Smyth, D. J., Balschun, T., Ban, M., Mistry, V., Ahmed, T., Barrett, J. C., Bhaw-Rosun, L., Bockett, N. A., Brand, O. J., Brouwer, E., Concannon, P., Cooper, J. D., Dias, K-R. M., van Diemen, C. C., Dubois, P.C., Edkins, S., Fölster-Holst, R., Fransen, K., Glass, D. N., Heap, G. A. R., Hofmann, S., Huizinga, T. W. J., Hunt, S., Langford, C., Lee, J., Mansfield, J., Giovanna Marrosu, M., Mathew, C. G., Mein, C.A., Müller-Quernheim, J., Nutland, S., Onengut-Gumuscu, S., Ouwehand, W., Pearce, K., Prescott, N., Posthumus, M. D., Potter, S., Rosati, G., Sambrook, J., Satsangi, J., Schreiber, S., Shtir, C., Simmonds, M. J., Sudman, M., Thompson, S. D., Toes, R., Trynka, G., Vyse, T. J., Walker, N. M., Weidinger, S., Zhernakova, A., Zoledziewska, M., Weersma, R.K., Gough, S.C.L., Sawcer, S., Wijmenga, C., Parkes, M., Cucca, F., Franke, A., Deloukas, P., Rich, S. S., Todd, J. A., van Heel, D. A., Hunt, K. A., Smyth, D. J., Balschun, T., Ban, M., Mistry, V., Ahmed, T., Barrett, J. C., Bhaw-Rosun, L., Bockett, N. A., Brand, O. J., Brouwer, E., Concannon, P., Cooper, J. D., Dias, K-R. M., van Diemen, C. C., Dubois, P.C., Edkins, S., Fölster-Holst, R., Fransen, K., Glass, D. N., Heap, G. A. R., Hofmann, S., Huizinga, T. W. J., Hunt, S., Langford, C., Lee, J., Mansfield, J., Giovanna Marrosu, M., Mathew, C. G., Mein, C.A., Müller-Quernheim, J., Nutland, S., Onengut-Gumuscu, S., Ouwehand, W., Pearce, K., Prescott, N., Posthumus, M. D., Potter, S., Rosati, G., Sambrook, J., Satsangi, J., Schreiber, S., Shtir, C., Simmonds, M. J., Sudman, M., Thompson, S. D., Toes, R., Trynka, G., Vyse, T. J., Walker, N. M., Weidinger, S., Zhernakova, A., Zoledziewska, M., Weersma, R.K., Gough, S.C.L., Sawcer, S., Wijmenga, C., Parkes, M., Cucca, F., Franke, A., Deloukas, P., Rich, S. S., Todd, J. A., and van Heel, D. A.

Abstract

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