Author: "Dučić, Siniša" - Searchworks@Jio Institute Digital Library Search Results

90 results on '"Dučić, Siniša"'

1. An Eastern Europe and Middle East multinational expert Delphi consensus study on the prevention, diagnosis, and treatment of developmental dysplasia of the hip before walking age

Author: Ömeroğlu, Hakan, Yüksel, Selcen, Demir, Pervin, Alexiev, Venelin, Alsiddiky, Abdulmonem, Anticevic, Darko, Bozinovski, Zoran, Bytyqi, Cen, Cosma, Dan, Dučić, Siniša, Hegazy, Abdelsalam, Kanashvili, Bidzina, Koloyan, Garen, Metaxiotis, Dimitris, Şenaran, Hakan, Shahcheraghi, Gholam-Hossain, Shitrit, Reuven, and Yazici, Muharrem
Published: 2024
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2. Intolerance of gluten-containing cereals

Author: Leković Zoran, Radlović Vladimir, Mladenović Marija, Dučić Siniša, Rosić Petar, Đuričić Goran, Predojević-Samardžić Jelica, and Radlović Nedeljko
Subjects: gluten-containing cereals, clinical forms of intolerance, celiac disease, diagnostics, nutrition, pediatrics, Medicine
Abstract: Intolerance of gluten containing cereals (wheat, rye, and barley) is an etiopathogenetically heterogeneous and relatively common problem of modern man. It occurs as an adverse immune-mediated condition in genetically predisposed individuals. According to the pathogenetic mechanism of intolerance to the components of these cereals, it is classified into celiac disease as an autoimmune disease, wheat allergy as an allergic disease, and non-celiac gluten sensitivity as a non-autoimmune and non-allergic disease. Each of these disorders is characterized by specific intestinal and/or extraintestinal manifestations, which resolve on a gluten-free diet. This review article presents the basic characteristics of these disorders in accordance with modern knowledge.
Published: 2024
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3. Celiac disease - a comprehensive review

Author: Radlović Nedeljko, Leković Zoran, Mladenović Marija, Vuletić Biljana, Radlović Jelena, Dučić Siniša, and Nikolić Dejan
Subjects: celiac disease, pathogenesis, clinical forms, diagnostics, Medicine
Abstract: Celiac disease is a multisystemic autoimmune disease induced by gluten in wheat, rye, and barley. It is characterized by polygenic predisposition, prevailing prevalence in members of the white population (1%), especially in close relatives (5–15%), very heterogeneous expression and frequent association with other autoimmune diseases (3–10%), as well as selective deficiency of IgA and Down, Turner, and Williams syndromes. The basis of the disease and the key finding in its diagnostics is gluten-sensitive enteropathy, i.e., non-specific inflammation of the small intestinal mucosa which resolves by gluten-free diet. In addition to enteropathy, whether symptomatic or asymptomatic, the disease is also characterized by various extraintestinal manifestations, and even very serious complications. Therapy is based on a lifelong glutenfree diet, so that the disorder, if diagnosed in time and treated consistently, has an excellent prognosis.
Published: 2023
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4. Prevalence and clinical forms of celiac disease in siblings of children with verified disease

Author: Leković Zoran, Radlović Vladimir, Mladenović Marija, Dučić Siniša, Đuričić Goran, Predojević-Samardžić Jelica, Vuletić Biljana, Rosić Petar, Janković Srđa, and Radlović Nedeljko
Subjects: celiac disease, children, siblings, prevalence, Medicine
Abstract: Introduction/Objective. Celiac disease (CD) is the result of a polygenic predisposition and gluten-containing diet. The aim of this study was to determine the prevalence and clinical forms of CD in siblings of children with verified disease. Methods. The study included 83 siblings, aged 1.5–27 (11.77 ± 6.2) years, of 64 children with CD diagnosed according to ESPGHAN criteria (1990/2012). In addition to a detailed history and clinical examination, serum levels of IgA and antibodies to tissue transglutaminase (AtTG) IgA and IgG classes were determined in all subjects. All with elevated AtTG levels underwent multiple duodenal enterobiopsy. The diagnosis of CD was confirmed by the finding of characteristic histological changes. Results. The diagnosis of CB was made in 13 of 83 subjects (15.67%). Nine of them had an asymptomatic form of the disease, while in the others the disease was clinically manifested – in three the form was classical, in one it was accompanied by severe malnutrition (-26.80%), and in one the manifestation was nonclassical (only short stature). Except for sideropenia and hypoferritinemia in four patients, of which two with hemoglobin below the reference value, standard laboratory findings were within normal limits. Conclusion. Our research shows that the prevalence of CD in siblings of children with verified disease is 15.67%. It is mostly detected in its asymptomatic form. In accordance with this, routine application of serological screening for CD in this population group is necessary for its timely diagnosis and treatment.
Published: 2023
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5. Gilbert syndrome as a risk factor for the development of cholelithiasis in children

Author: Radlović Vladimir, Golubović Zoran, Leković Zoran, Dučić Siniša, Radlović Nedeljko, Jovanović Branislav, Bukva Bojan, Pavićević Polina, Nikolić Dejan, and Janković Jovana
Subjects: gilbert syndrome, cholelithiasis, children, Medicine
Abstract: Introduction/Objective. Gilbert syndrome (GS) is the most common hereditary hyperbilirubinemia. As well as mild unconjugated hyperbilirubinemia, it is characterized by the excess of bilirubin monoglucuronide over diglucuronide in the bile and thus increases the risk of biliary calculosis. The aim of the study was to determine the importance of GS as a risk factor in the development of cholelithiasis in children. Methods. The study included a sample of 31 children (14 male and 17 female, mean age 12.16 ± 4.11 years, range 3–16.75 years) with symptomatic cholelithiasis. The diagnosis of cholelithiasis was based on an ultrasonographic finding, and for GS the diagnosis was based on at least a double increase of unconjugated bilirubin fraction after a three-day hypocaloric diet (400 kcal per day). Results. GS was confirmed in five or 16.13% of patients (three male and two female, mean age 14.71 ± 0.55 years, range 14–15.3 years). In addition to GS, in the history of the disease they all had some of the additional risk factors for the development of cholelithiasis. One of them had an identical problem as its mother, one had hereditary elliptocytosis, one had sudden weight loss, one was overweight, and one had premature birth and sepsis. Conclusion. GS registers in one-sixth of children with cholelithiasis, but in none of them as the only risk factor for developing this disease. This finding suggests that GS is a risk factor for the development of cholelithiasis, but not sufficient in itself in that respect.
Published: 2023
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6. Elective surgery system strengthening: development, measurement, and validation of the surgical preparedness index across 1632 hospitals in 119 countries

Author: Glasbey, James C, Abbott, Tom EF, Ademuyiwa, Adesoji, Adisa, Adewale, AlAmeer, Ehab, Alshryda, Sattar, Arnaud, Alexis P, Bankhead-Kendall, Brittany, Abou Chaar, M K, Chaudhry, Daoud, Costas-Chavarri, Ainhoa, Cunha, Miguel F, Davies, Justine I, Desai, Anant, Elhadi, Muhammed, Fiore, Marco, Fitzgerald, James Edward, Fourtounas, Maria, Fowler, Alex James, Futaba, Kay, Gallo, Gaetano, Ghosh, Dhruva, Gujjuri, Rohan R, Hamilton, Rebecca, Haque, Parvez, Harrison, Ewen M, Hutchinson, Peter, Hyman, Gabriella, Isik, Arda, Jayarajah, Umesh, Kaafarani, Haytham MA, Kadir, Bryar, Lawani, Ismail, Lederhuber, Hans, Li, Elizabeth, Löffler, Markus W, Lorena, Maria Aguilera, Mann, Harvinder, Martin, Janet, Mazingi, Dennis, McClain, Craig D, McLean, Kenneth A, Meara, John G, Ramos-De La Medina, Antonio, Mengesha, Mengistu, Minaya, Ana, Modolo, Maria Marta, Moore, Rachel, Morton, Dion, Nepogodiev, Dmitri, Ntirenganya, Faustin, Pata, Francesco, Pearse, Rupert, Picciochi, Maria, Pinkney, Thomas, Pockney, Peter, van Ramshorst, Gabrielle H, Richards, Toby, Roslani, April Camilla, Satoi, Sohei, Sayyed, Raza, Shaw, Richard, Simões, Joana FF, Smart, Neil, Sullivan, Richard, Sund, Malin, Sundar, Sudha, Tabiri, Stephen, Taylor, Elliott H, Venn, Mary L, Wickramasinghe, Dakshitha, Wright, Naomi, Yip, Sebastian Bernardo Shu, Bhangu, Aneel, Omar, Omar, Harrison, Ewen, Bhangu, Aneel A, Siaw-Acheampong, Kwabena, Benson, Ruth A, Bywater, Edward, Dawson, Brett E, Evans, Jonathan P, Heritage, Emily, Jones, Conor S, Kamarajah, Sivesh K, Khatri, Chetan, Khaw, Rachel A, Keatley, James M, Knight, Andrew, Lawday, Samuel, Mann, Harvinder S, Marson, Ella J, Mckay, Siobhan C, Mills, Emily C, Pellino, Gianluca, Tiwari, Abhinav, Trout, Isobel M, Wilkin, Richard JW, Abukhalaf, Sadi, Adamina, Michel, Ademuyiwa, Adesoji O, Agarwal, Arnav, Akkulak, Murat, Alameer, Ehab, Alderson, Derek, Alakaloko, Felix, Albertsmeier, Markus, Alser, Osaid, Alshaar, Muhammad, Augestad, Knut Magne, Ayasra, Faris, Azevedo, José, Bankhead-Kendall, Brittany K, Barlow, Emma, Beard, David, Blanco-Colino, Ruth, Brar, Amanpreet, Minaya-Bravo, Ana, Breen, Kerry A, Bretherton, Chris, Buarque, Igor Lima, Burke, Joshua, Caruana, Edward J, Chaar, Mohammad, Chakrabortee, Sohini, Christensen, Peter, Cox, Daniel, Cukier, Moises, Davidson, Giana H, Di Saverio, Salomone, Drake, Thomas M, Edwards, John G, Emile, Sameh, Farik, Shebani, Ford, Samuel, Garmanova, Tatiana, Gomes, Gustavo Mendonça Ataíde, Grecinos, Gustavo, Griffiths, Ewen A, Gruendl, Magdalena, Halkias, Constantine, Hisham, Intisar, Hutchinson, Peter J, Hwang, Shelley, Jenkinson, Michael D, Jonker, Pascal, Keller, Debby, Kolias, Angelos, Kruijff, Schelto, Leventoglu, Sezai, Litvin, Andrey, Loehrer, Andrew, Major, Piotr, Mashbari, Hassan N, Metallidis, Symeon, Mohan, Helen M, Moszkowicz, David, Moug, Susan, Ng-Kamstra, Joshua S, Maimbo, Mayaba, Negoi, Ionut, Niquen, Milagros, Olivos, Maricarmen, Oussama, Kacimi, Outani, Oumaima, Parreno-Sacdalanm, Marie Dione, Rivera, Carlos Jose Perez, Pinkney, Thomas D, Plas, Willemijn van der, Qureshi, Ahmad, Radenkovic, Dejan, Revell, Elliot J, Roberts, Keith, Roslani, April C, Rutegård, Martin, Segura-Sampedro, Juan José, Santos, Irène, Schache, Andrew, Schnitzbauer, Andreas A, Seyi-Olajide, Justina O, Sharma, Neil, Shaw, Catherine A, Shu, Sebastian, Soreide, Kjetil, Spinelli, Antonino, Stewart, Grant D, Townend, Philip, Tsoulfas, Georgios, Vidya, Raghavan, Vimalachandran, Dale, Warren, Oliver J, Wedderburn, Duane, EuroSurg, NA, European Society of Coloproctology (ESCP), NA, Global Initiative for Children's Surgery, NA, GlobalSurg, NA, GlobalPaedSurg, NA, ItSURG, NA, PTSurg, NA, SpainSurg, NA, Italian Society of Colorectal Surgery, NA, Association of Surgeons in Training, NA, Irish Surgical Research Collaborative (ISRC), NA, Transatlantic Australasian Retroperitoneal Sarcoma Working, NA, Italian Society of Surgical Oncology, NA, Booth, Lesley, Barker, Margaret, Barker, Neil, Cooke, Shirley, Doré, Suzanne, Horwood, Nigel, Runigamugabo, Emmy, Weir, Carrie Tierney, Bahrami-Hessari, Mike, Riaz, Asad, Shah, Jaffer, Safi, Mohammed, Thereska, Dariel, Dajti, Irida, Cheddadi, Riadh, Tidjane, Anisse, Quinteros, Carlos A, khelfaoui, Ahmed, Salem, Khalifa M, Riffi, Omar, Kacimi, Salah Eddine O, Loudjedi, Salim, Damerdji, Tidjani, Pantoja Pachajoa, Diana A, Palacios Huatuco, René M, Alvarez, Fernando A, Doniquian, Alejandro M, Abeldaño Zuñiga, Roberto A, Schlottmann, Francisco, Cobos, Carlos M, Gigena, Cecilia, Forneris, Agustin Albani, Duro, Agustin, García-Mansilla, Agustín M, Busnelli, Virginia Cano, Poggi, Catalina, Mercado, Pedro L, González, Marcos, Castro Lalin, Agustina F, Mayer, Horacio F, Brandariz, Rodrigo, Slullitel, Pablo A, Boudou, Rocio, Lobos, Pablo A, Uffelmann, María C, Petersen, Maria L, Luzzi, Emilia, Padilla Lichtenberger, Fernando L, Crespi Amor, María S, Zarratea, Celeste S, Esteves, Tomas A, Gemelli, Nicolas A, Tirapegui, Sebastián, Liyo, Juan, Scherñuk, Jordán, Boccalatte, Luis A, Balmaceda, Ruben D, D'Addino, Jose L, Caubet, María M, Calderón Arancibia, José A, Chwat, Carina, Morris, Brian, Avellaneda, Nicolas, Pedraza Salazar, Ivana I, Eskinazi, Diego G, Vargas, Lara, Muriel, María E, Lucchini, Sergio M, Gosselink, Martijn P, Davis, Amelia L, Barker, John C, Qin, Kirby R, Proud, David M, Cox, Daniel RA, Goh, Su Kah, Liu, David S, Wu, Damien M, Merrett, Neil D, Badiani, Sarit S, Sengupta, Shomik, Jain, Anshini, Steen, Christopher J, Wong, Enoch, Ip, Christopher CK, Leaning, Matthew G, McCartney, Conor B, Gananadha, Sivakumar, Yeap, Evie FW, Stevens, Sean G, Vu, Anh N, Martin, Sarah A, Stanley, Guy H M, Watson, David I, Townend, Philip J, Young, Thomas K, Cox, Georgia T, Dawson, Amanda C, Laura, Sharon E, Lun, Elizabeth W Y, Liang, Ina X, O'Neill, Christine J, Lott, Natalie J, Chuan, Alwin, Saravanan, SK, Gundara, Justin, Ong, Bee Shan, Nataraja, Ramesh M, Pacilli, Maurizio, Foley, Daniel M, Ooi, Geraldine J, Traeger, Luke, MacDermid, Ewan, Daruwalla, Jurstine, Hodgson, Russell, Heriot, Alexander G, Mulligan, Christopher S, Blefari, Nicholas D A, Purcell, Shaun S, Frankel, Adam J, Guerra, Glen R, Tefay, Joan S, Liang, Rhea W Y, Kroon, Hidde M, Farfus, Anthony W, Warren, Leigh R, Roy, Jennifer M, Whitfield, Robert J, Moller, Cea-Cea B, Davis, Sean S, Sammour, Tarik, Lam, Yick Ho, Kour, Kevin, Gan, Siang Wei, Coventry, Brendon J, Dawson, Joseph A, Batstone, Martin D, King, Sebastian K, Scott, Nathan J, Foo, Jonathan W, Shepherd, Talia, Page, Richard S, Choong, Peter F, Badgery, Henry E, Chong, Lynn, Taylor, Lillian, Hii, Michael W, Wright, Gavin M, Kong, Joseph CH, Watson, Matthew M, Bock, Jacob, Lidder, Surjit S, Elias, Patrick, Kanavathy, Sathisvaran, Koh, Cherry E, Chennakesavan, Srinivas Kondalsamy, Panuganti, Vishwakar, Latif, Haider, Yeung, Justin MC, Besson, Alex J, Tse, Eunice Q Y, Pitcher, Meron E, Taylor, Danielle L, Nahm, Christopher B, Lim, Alicia, Tree, Kevin, Aigner, Felix, Dawoud, Christopher, Foessleitner, Philipp, Zimmermann, Matthias, Wiedemann, Dominik, Findl, Oliver, Messner, Franka, Bauer, Marlies, Nägele, Felix, Kronberger, Irmgard E, Öfner, Dietmar, Härter, Bettina, Bicz, Nina Ru B, Zwittag, Paul M, Poier, Nikolaus, Navarro, Francisco Ruiz, Zebuhr, Yorck A, Köglberger, Paul, Wiesinger, Clemens G, Mathew, Erwin, Trivik-Barrientos, Felipe, Königsrainer, Ingmar, Djedovic, Gabriel, Cohnert, Tina U, Lumenta, David B, Singer, Georg, Leithner, Andreas, Kamolz, Lars-Peter, Andrianakis, Alexandros, Puchwein, Paul, Mikalauskas, Saulius, Kirchweger, Patrick, Függer, Reinhold, Mittermair, Christof, Russe, Elisabeth, Paal, Peter, Grünbart, Martin, de Cillia, Michael, Weiss, Helmut G, Steiner, Florian, Binder, Alf Dorian, Samadov, Elgun, Ibrahimli, Arturan, Muslumov, Gurbankhan, Bayramov, Nuru Y, Saunders, Jada M, Almoosa, Noora, Haj-Ibrahim, Huzifa, Maresch, Martin, Ezzdean, Weaam K, Juma, Isam M, Hasan, Layla H, Haider, Fayza HA, Alfaqawi, Ghassan Salman, Alam, Mohammed S, Islam, Shahnoor, Basher, AKM K, Mitul, Ashrarur Rahman, Islam, Nazmul, Oosterkamp, Antje E, Ahmed, Tanveer, Hannan, M Jafrul, Padmore, Greg M, Doyle, Alex F, LaCorbiniere, Karisha L, Boyce, Rico D R, Ragoobar, Paul T, Walkes, Keisha M Y, Haynes, Amelia A, Corbin, Sasha M, Litvina, Yauheniya A, Makhmudov, Anvar, Strypstein, Sébastien, Dhondt, Bert, Rasschaert, Ricky, Farid, Yasser, Wahib, El Mahdi, Pigeolet, Manon, Belle, Koen Van, De Wachter, Stefan, Komen, Niels, Vandeputte, Mathieu PJ, Jansen, Yanina JL, Stijns, Jasper, Eynde, Jef Van den, Olowo, Benedicte I, Feraudy, Israel C, Dragisic, Vedran, Martinovic, Vlatka, Barišić, Tatjana, Penava, Nikolina, Hudic, Igor, Delibegovic, Samir, Bogdanović, Gordana, Grgić, Gordana, Cerovac, Anis, Cerovac, Elmedina, Bedada, Alemayehu G, Baiocchi, Glauco, Wainstein, Alberto, Moisés, Elaine Christine D, Zani, Ana Carolina Tagliatti, de Campos Prado, Caio Antonio, Panis, Carolina, Rech, Daniel, Soares da Silva, Ruan Gabriel, Joviliano, Edwaldo E, Rezende, Ricardo F, Reis, Igor G N, Pires, Robinson E S, Christiano, Adriana Borgonovi, Consani, Heitor F X, Pugliesi, Felipe G, Takeda, Flavio R, Mariani, Alessandro W, Valadares, Ricardo J B, Andreollo, Nelson A, Lopes, Luiz Roberto, Tonello, Cristiano, Alonso, Nivaldo, dos Santos, Carlos Ferreira, Lima, Leonardo S, Salgado, Wilson, Pereira, Thiago H S, Gatti, Arthur Paredes, Oliva, Ramon N L, Nardi, Caroline N, Sousa, Alvaro F L, Ribeiro, Ivonizete P, Carvalho, Herica E F, Oliveira, Layze B, Schneider, Guilherme, Casteleins, William Augusto, Silva, Larissa M, Gomes, Carlos Augusto, da Cunha Viana Júnior, Alonço, Cruz, Ricardo P, Gomes, Gustavo MA, Buarque, Igor L, Barros, Aldo V, Marangon, Gustavo B, Flumignan, Ronald LG, Nakano, Luís CU, Pascoal, Patrícia IF, Santos, Brena C, Kuramoto, Danielle AB, Correia, Rebeca M, Amaral, Fabio CF, Flumignan, Carolina DQ, Dussán-Sarria, Jairo A, Simões, Romeo L, Amorim, Robson L, Silva, Jeancarllo S, Lyra Junior, Humberto F, Julio, Nathalia S, Gerber, Marlus T, dos Santos, José Mauro, de Oliveira, Joao Carlos C, Palamim, Camila VC, Marson, Fernando AL, Gomes, Iolanda M, Oliveira, Priscila R, Lima, Ana Lucia L M, Carvalho, Vladimir C, Silva, Jorge S, NA, Ulysses Ribeiro, Laporte, Gustavo Andreazza, Gonçalves, Mateus Capuzzo, Botacin, Lais S, Avelino, Melissa AG, Brito, Luiz Gustavo O, Hristova, Evguenia T, Stoyanov, Vladislav Valentinov, Sakakushev, Boris E, Dardanov, Dragomir D, Sokolov, Manol B, Mehta, Ananya, Gyokova, Elitsa H, Abdullahi, Mohamed, Karamanliev, Martin P, Dimitrov, Dobromir D, Slavchev, Mihail T, Atanasov, Boyko Ch, Yotsov, Tsanko I, Hadzhiev, Dimitar Bozhidarov, Stock, Simon E, Nwegbu, Chukwuemeka Gerald, Tanyi, Tanyi John, Brown, James A, Arneja, Jugpal S, Lee, Susan M, Kancherla, Ramya, Kidane, Biniam, Champagne, Pierre-Olivier, Ma, Xiya, Munro, Allana, McKeen, Dolores M, Glinka, Juan, Vasarhelyi, Edward M, Subramani, Yamini, Alfaro, Hilda, Shah, Ushma J, Gonzalez, Nelson J, MacNeil, S Danielle, Nagappa, Mahesh, Malthaner, Richard A, Brackstone, Muriel, Alkhamesi, Nawar A, Qiabi, Mehdi, Arango-Ferreira, Camila, Prempeh, Agya B A, Dumitra, Sinziana, Spence, Richard T, Bedard, Eric LR, Luc, Jessica GY, Johnston, Brian R, Attabib, Najmedden, Persad, Amit RL, Das, Sunit, Khoshbin, Amir, Ladha, Karim S, Sankar, Ashwin, Teja, Bijan, Daza, Julian F, Chan, Veronica F, Baertschiger, Reto M, Zani, Augusto, Nessim, Carolyn, McIsaac, Daniel I, Singh, Mandeep, Behzadi, Abdollah, Dell, Angela J, Al Riyami, Salim M, Dajani, Khaled Z, Bigam, David, Manikala, Vinod K, Street, John T, Mayson, Kelly V, Wallis, Christopher J D, Mimica, Ximena, Villanueva, Julio, Altamirano, Roberto, Waissbluth, Sofia, Marín, Diego I, Fonseca, Bruno Catoia, Hodali, Andrés J, Ramos, Andrea I, Valenzuela, Marco A, Torres, Janina J, Song, Yi, Yang, Wah, Aldanakh, Abdullah, Alradhi, Mohammed, Lyu, Yidong, Chen, Yan, Fletcher, Angélica V, Camargo, Daniela, Casanova, Rafael Figueroa, Medina, Camilo Andres Caicedo, Bolivar, Dinimo, Garcia, Tatiana Carolina Beltran, Pedraza, Nestor F, Garcia-Lopez, Andrea, Patino-Jaramillo, Nasly G, Giron, Fernando A, Rivera, Carlos J- Perez, Nieto-Calvache, Albaro José, Ariza, Fredy, Orozco-Chamorro, Claudia Milena, Nanez, Maria A, Garces, Diana S, Figueroa, Luis M, Badiel, Marisol, Martinez, Delio F, Coll-Tello, Brenda, Camelo, Hector F, Montoya Casella, Antonio J, Ordoñez, Sebastian, Velez Sanchez, Paola A, Salcedo, Juan C, Villegas, Lina M, Holguín, Jorge A, Cardozo, Jesús Hernán Tovar, Perdomo, Jorman Harvey Tejada, Perdomo, Valentina Gutiérrez, Rivera-Rincon, Natalia A, Gomez, Paula Torres, Delgado-Nieto, Elena Leonor, Isaza-Restrepo, Andres, Vargas, Felipe, Vargas, Ana M, Castro, Arnulfo Andrade, Navarro, Jorge A, Vargas, Saul E, Calvache, Jose A, Mendoza-Arango, Maria C, Bernal, Jorge Luis Vélez, Gonzalez, Felipe O, šantak, Goran, Kirac, Iva, Kršul, Dorian, Versic, Ana Bosak, Augustin, Goran, Kulis, Tomislav, Kastelan, Zeljko, Hadzibegovic, Ana Danic, Grsic, Kresimir, Hudolin, Tvrtko, Tarle, Marko, Mamic, Matija, Lorencin, Mia, Luksic, Ivica, Habek, Dubravko, Konjevoda, Suzana, Mihanovic, Jakov, Antoniou, Stavros A, Almezghwi, Heyam A, Gouvas, Nikolaos, Martinek, Lubomir, Novysedlak, Rene, Žatecký, Jan, Meyhoff, Christian S, Ellebæk, Mark Bremholm, Batista, Sylvia Jeanne, Rodriguez, Julia, Mejia De la Cruz, Dolores, Jimenez, Mirna Giselle Santiago, Dominguez, Carla M, Negrete, José R, Campuzano, Pedro N, Mogrovejo, Daniel L, Armas, Maria J, Arboleda-Bustan, Jenny E, Lincango-Naranjo, Eddy P, El-Kassas, Mohamed, Awad, Ahmed K, Alazab, Emad, Abdulmaseh, Kyrillos G, Diab, Sherein, El Wahab, Mostafa HAbd, Darwesh, Amr, Mostafa, Badr E, Abdelgalil, Mahmoud Shaban, Elbadawy, Merihan A, Reda, Ali M, Asla, Amir Fathi, Fayed, Notaila M, Ahmed, Mohamed S, Elsadek, Menan Ahmed, Gad, Dalia Elsayed, El Saadany, Aya Gameel, Elsadek, Aalaa Mohamed, Sayed, Ahmed E, Naeem, Ahmed, Al-Mallah, Abdullah, Abdelsamed, Ahmed A, Ewedah, Moataz, Soliman, Mohamed O, Tanas, Yousef, Hamouda, Mohammed, Mahfouz, Marina H, Abdo, Manal E, Dean, Yomna E, Lka, Karim, Abodeeb, Aya O, Ashoush, Fouad M F B, Elsherbiny, Roqaia R, Gadelkarim, Mohamed, Osman, Nermin A, MIbrahim, Maya, Youssef, Nehal G, Ibrahim, Mohamed Hamdy, Soliman, Antonios, Gadelkareem, Rabea A, Abbas, Ahmed M, Mohamed Hussein, Aliae AR, Abdelsattar, Khaled, Maher, Ahmed, Elabd, Mohamed M, Abdelazim, Hassan, Ibraheem, Maher H, Noureldin, Yasser A, Elfiky, Mahmoud, Ebrahim, Mohamed A, Abdelrahman, Ahmed Saber Mohamed, Marei, Mahmoud Marei, Elkhalawy, Aya M, Azzam, Ahmed Y, Azab, Mohammed A, Elmasry, Ahmed H, Elgazar, Amr, Shalaby, Mahmoud Mohamed Mohamed, Mahmoud, Mohammad S, Qassem, Mohamed G, Kinani, Hussein, Wahba, Abdelrahman M, Ezzat, Rana Hisham, Ahmed, Mai H, Elshawy, Mohamed Elemam, Faragalla, Hazem Metwally, Mahmoud, Khalid D, Nafea, Ahmed M, Abdel-Maboud, Mohamed, Abozied, Hesham, Moharam, Modather, Shehata, Ashraf H, ElKafrawy, Samir A, Tayiawi, Mosaab M, Elghadban, Hosam M, Emara, Moataz M, Shehta, Ahmed, Saqr, Amira M, Abdelelsalm, Wafaa M, Elshennawy, Eslam M, Radwan, Samar T, Awad, Selmy S, Emile, Sameh H, Aldosoky, Wesam A, Elfeki, Hossam, Gendi, Sara N, Abdelsalam, Hala Adel, Hammad, Mohammed, Shalaby, Mostafa, Sakr, Ahmad Hammad, Abdelmaksoud, Mohamed A, Alawady, Mohammed, Omran, Abdelrahman Azzam, Allam, Abdallah R, Ismail, Zainab, Gaballah, Khaled M, AlGady, Mahmoud Fathy Mahmoud, Raslan, Ahmed M, Gharbia, Khaled, Nuser, Abdelazez A, Sayed, Ahmed Kamal, Elshahawy, Mahmoud A, Ghaly, Galal, Sherif, Ahmed Elshawadfy, Makram, Abdelrahman M, Makram, Omar M, Ahmed, Ola, Helmy, AbdelRahman M A, Abdelwahab, Khaled M, Abdelkhalek, Mohamed, Metwally, Islam H, Shetiwy, Mosab Saad, Zuhdy, Mohammad, Ramadan, Salma I, Abdelghany, Mohamed, Omar, Mohammed A, Soliman, Ziad A, Ali, Hossam T, Elnoamany, Salma, Ghozy, Sherief, Abbas, Alzhraa S, Shehata, Mostafa A, Mahmoud, Sahar A, Elsaman, Mohammed A, Fayad, Elsayed A, Radwan, Asmaa, El-Sakka, Ahmed I, Sallam, Asser, Elbahnasawy, Mohamed G, 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Kumer, Sean C, Larson, Kelsey, Turner, Scott, Guidry, Christopher, Reddy, Madhuri, Berbel, German, Findley, Austin, Beahm, David, Bur, Andres, Marlor, Derek, Houndschell, Corey, Carver, Shea, Ulrich, Alissa, Bhutiani, Neal, DiChiacchio, Laura, Abdou, Hossam, Napolitano, Lena M, Ghebre, Rahel, Bass, Gary Alan, Kaplan, Lewis J, Martin, Niels D, Duffy, Caoimhe C, Abdelhamid, Sultan S, Daley, Brian J, Roland, Christina L, Dumas, Ryan P, Ban, Vin Shen, Rajesh, Aashish, Davies, Mark G, Purudappa, Prabhudev P, Walters, Camila B, Lin, Nicole, Ruzgar, Nensi M, Ullrich, Sarah J, Trostchansky, Ivan, Bonilla-Cal, Fernando, Castedo, Fabiola, Sobrero, Helena, Acuña, Gastón, Álvarez, Sofía M, Tarigo, Josefina, Carbajal, Ana C, Carbajal, Ana, Reyes, Antonio R, Al-Eryani, Fatima A, Alqousi, Nardeen N, Alattas, Zainab, Al-Saban, Rafat A, Al-Shehari, Mohammed M, ALHammadi, Nawal T, Shream, Sarah A, Al-Naggar, Hamza M, Al-Qalisi, Lina M, Nadeesh, Areej E, Al-Samawi, Hytham H, Bajjah, Hadeel M, AL-Ameri, Saba A, Albably, Jamal F, Ghannam, Rana A, Shamsan, Amatallah H, Meead, Abdullah A, Al- Zubaidi, Riham Q, Zulait, Mohammed A, Najeeb, Halah, Alsayadi, Musaed M, Al-Mashreqi, Seham K, Al-Jomai, Najla A, Alsayadi, Ramzi A, Al-Naggar, Moath M, Almarashi, Hassan A, Musaeed, Hasna M, Al-Raimi, Ibrahim M, Ghanem, Hossam N, Al-Zazay, Karim A, AL-Mahdi, Shehab A, Almontaser, Amatalaleem S, Savopoulos, Vanessa A S, Munthali, James, Kabongo, Kizito M C, Mushiwokufa, Willard, Ngulube, Allan, Ntoto, Crispin, Magama, Praise T, Dzinotyiwei, Daniel, Chivanga, Shelton K, Dube, Ngqabutho S, Sanchez, Ernesto C, Moyo, Assel T, Chengahomwe, Antony, Chinyowa, Simbarashe, Siamuchembu, Maphios, Bondera, Tafadzwa, and Mushawarima, Trust
Published: 2022
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7. Clinical features of non-classical celiac disease in children and adolescents

Author: Radlović Nedeljko, Leković Zoran, Radlović Vladimir, Mandić Jelena, Mladenović Marija, Radlović Jelena, Vuletić Biljana, Dučić Siniša, Bukva Bojan, and Dašić Ivana
Subjects: nonclassical celiac disease, children and adolescents, symptoms and signs, Medicine
Abstract: Introduction/Objective. Nonclassical celiac disease (CD) is characterized by a very heterogeneous and non-specific clinical presentation. The aim of this study was to determine the basic symptoms and clinical signs of this CD subtype in children and adolescents Methods. The study was based on a sample of 58 children and adolescent, 38 female and 20 male, ages 1.75 to 17.75 (10.01±4.62) years with a nonclassical CD diagnosed according to the European Society for Pediatric Gastroenterology, Hepatology and Nutrition criteria from 1990 and 2012. Results. Except four patients who were between the ages of 1.75 to 2.50 years, all others were older than three years. The main clinical symptoms and signs suggestive of non-classical CD were anemia caused by iron deficiency (48.28%), short stature (34.48%), and intermittent abdominal pain (18.97%), anorexia with stagnation or weight loss (13.79%), and chronic constipation (6.9%). Thirty patients had one symptom or sign of the disease, 15 had two and 13 had three. In addition, 12 patients had dental enamel hypoplasia, 18 sideropenia without anemia and five mild isolated hypertransaminasemia. A gluten-free diet, apart from the dental enamel hypoplasia, has resulted in the withdrawal of all indicators of the disease. Conclusion. The main symptoms and clinical signs of nonclassical CD in children and adolescents were iron deficiency anemia, short stature and intermittent abdominal pain, and less frequently anorexia with stagnation or weight loss and chronic constipation. Excluding dental enamel hypoplasia, a gluten-free diet leads to a complete recovery of the patient.
Published: 2021
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8. Combined technique with hydroxyapatite coated intramedullary nails in treatment of anterolateral bowing of congenital pseudarthrosis of tibia

Author: Popkov, Dmitry, Popkov, Arnold, Dučić, Siniša, Lazović, Mikan, and Lascombes, Pierre
Published: 2020
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9. Benign transient hyperphosphatasemia in children

Author: Radlović Nedeljko, Leković Zoran, Radlović Vladimir, Dučić Siniša, Golubović Zoran, Mladenović Marija, Mahmutović Meho, Pavićević Polina, Đurićić Goran, and Petrović-Tepić Snežana
Subjects: benign transient hyperphosphatasemia, diagnostics, children, Medicine
Abstract: Introduction/Objective. Benign transient hyperphosphatasemia (BTH) is a pathogenetic insufficiently clear clinical entity that is mostly seen in infants and young children. The objective of this paper is to present our experience regarding the age of occurrence, the conditions of the discovery, and the length of duration of BTH in children. Methods. The study was realized on a sample of 18 children, nine boys and nine girls, aged 10–42 (21.06 ± 9.35) months with BTH. The diagnosis of BTH is based on the absence of bone and hepatobiliary diseases, and its spontaneous disappearance over the course of several months. Results. One patient was in the first year, 13 in the second, three in the third, and one in the fourth. Isolated high activity of serum alkaline phosphatase, which was 2.04–21.9 (8.05 ± 5.31) times above the upper reference value for the corresponding age, in 14 cases it was found during the acute diarrhea, and in four with acute rhinopharyngitis, of which in two complicated with otitis media. The cause of diarrhea in six cases was rotavirus, in two Campylobacter, and in one adenovirus, and otitis media in one case was caused by Streptococcus pneumoniae, while in others, etiologic factors of infection were not identified. Spontaneous normalization of serum alkaline phosphatase activity was recorded between one and three months after the onset. Conclusion. BTH is a harmless biochemical disorder that spontaneously subsides within three months after initial observation. It is found randomly as a routine laboratory finding most often within the treatment of acute gastrointestinal and respiratory infections.
Published: 2020
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10. Outcomes and special techniques for treatment of penile amputation injury

Author: Djordjevic, Miroslav L., Bizic, Marta, Stojanovic, Borko, Joksic, Ivana, Bumbasirevic, Uros V., Ducic, Sinisa, Mugabe, Herbert, Krstic, Zoran, and Bumbasirevic, Marko Z.
Published: 2019
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11. Limb lengthening and deformity correction in children with abnormal bone

Author: Popkov, Arnold, Dučić, Siniša, Lazović, Mikan, Lascombes, Pierre, and Popkov, Dmitry
Published: 2019
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12. Recurrent aphthous stomatitis as the only clinical sign of celiac disease in obese adolescent - case report and literature review

Author: Mandić Jelena, Radlović Nedeljko, Leković Zoran, Radlović Vladimir, Dučić Siniša, Nikolić Dejan, and Jovičić Olivera
Subjects: recurrent aphthous stomatitis, celiac disease, obesity, Medicine
Abstract: Introduction. Recurrent aphthous stomatitis (RAS) is a relatively common oral mucosal lesion of unclear etiology. It occurs in otherwise healthy people, but also in various infectious and non-infectious diseases, including celiac disease (CD). We present an obese adolescent with RAS as the only clinical sign of CD. Case outline. An adolescent aged 15 2/12 years come with very pronounced RAS in previous five months. He had no other difficulties. The patient was obese from the age of 12. Other data were without peculiarities. On admission he was 165 cm tall (P25), obese (BMI 27 kg/m2), in the final stage of puberty, with stretch marks in the distal areas of the abdomen, thighs and gluteus and very pronounced pain-sensitive aphthae in the buccal and labial mucosa accompanied by swelling of the lips and perioral region. Except for lower serum iron levels (8 μmol/l), routine laboratory blood tests were within the reference range. The serological test for CD was positive (antibodies to tissue transglutaminase IgA 78.5 U/ml, anti-endomysial antibodies IgA positive). Endoscopy revealed reflux esophagitis, without any other pathological findings. Stereomicroscopic and pathohistological analysis of the duodenal mucosa samples showed mild destructive enteropathy (Marsh IIIa). Pathohistological examination of the gastric mucosa revealed grade I-II lymphocytic gastritis. The urease test for Helicobacter pylori was negative. A gluten-free diet resulted in the withdrawal of aphthous stomatitis and no recurrence later. Conclusion. Within the differential diagnostic analysis of the RAS causes, CD should also be considered. Additionally, obesity does not exclude the presence of CD.
Published: 2020
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13. An Eastern Europe and Middle East multinational expert Delphi consensus study on the prevention, diagnosis, and treatment of developmental dysplasia of the hip before walking age

Author: Ömeroğlu, Hakan, primary, Yüksel, Selcen, additional, Demir, Pervin, additional, Alexiev, Venelin, additional, Alsiddiky, Abdulmonem, additional, Anticevic, Darko, additional, Bozinovski, Zoran, additional, Bytyqi, Cen, additional, Cosma, Dan, additional, Dučić, Siniša, additional, Hegazy, Abdelsalam, additional, Kanashvili, Bidzina, additional, Koloyan, Garen, additional, Metaxiotis, Dimitris, additional, Şenaran, Hakan, additional, Shahcheraghi, Gholam-Hossain, additional, Shitrit, Reuven, additional, and Yazici, Muharrem, additional
Published: 2023
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14. Treatment of slipped capital femoral epiphysis - a comparative study during twelve years period

Author: Bukva Bojan, Dučić Siniša, Radlović Vladimir, Vrgoč Goran, Krivokapić Branislav, Jelaska Igor, and Mandić-Jelaska Petra
Subjects: transcervical fixation, cannulated screw, closed reduction, Medicine
Abstract: Introduction/Objective. The purpose of this study was to compare two methods of treatment and to evaluate the advantages in the final outcome of transcervical fixation of the femoral head using one cannulated screw in the treatment of slipped capital femoral epiphysis. Methods. This study included 65 pediatric patients (35 boys and 30 girls), aged 6–16 years (average 11.86), during a 12-year period (2000–2012). We compared the slipping degree before and after the treatment (Southwick angle), the range of motion before and after treatment, and complication occurrence between two groups of children. The first group of children (26 patients) underwent closed reduction and cast immobilization (Group I). The other group (39 patients) was treated with transcervical fixation using one cannulated screw (Group II). Results. Comparing preoperative and postoperative Southwick angle, we found much better improvement in Group II, but without statistical significance between the two groups of patients (p = 0.09). Observing the range of motion of the hips before and after treatment, we found improvement in both groups of patients, especially in patients treated using transcervical fixation with cannulated screw (Group II). In complication occurrence, the patients in Group II had less complication occurrence compared to Group I (p = 0.02). Conclusion. The transcervical fixation using one cannulated screw has better clinical outcome and lower complication rate in relation to closed reduction and cast immobilization in the treatment of slipped capital femoral epiphysis.
Published: 2019
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15. Isolated hypertransaminasemia in children up to two years with classical celiac disease

Author: Radlović Nedeljko, Leković Zoran, Mladenović Marija, Radlović Vladimir, Vuletić Biljana, Dučić Siniša, Golubović Zoran, Mahmutović Meho, and Petrović-Tepić Snežana
Subjects: isolated hypertransaminasemia, classical celiac disease, children up to 2 years, Medicine
Abstract: Introduction/Objective Isolated hypertransaminasemia (IHTS) is a common, benign, and transient appearance in patients with celiac disease (CD). The aim of this study is to determine the frequency of IHTS in children up to two years old with clinically classical CD, as well as its connection with the onset of the first symptoms of the disease, the age of diagnosis, the clinical and laboratory nutritional parameters, and the degree of damage of small intestinal mucosa. Methods The study was based on a sample of 82 children, 55 female and 27 male, ages 7–24 (14.28 ± 4.41) months. The diagnosis of CD was based on the revised ESPGHAN criteria and the activity of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) by standard laboratory methods. Results IHTS was found in 39 (47.56%) patients, 27 of whom (69.23%) had elevated levels of both transaminases and 12 of only one – eight of AST and four of ALT. The increase in relation to the aforementioned reference value for ALT was 1.1–10.08 (1.67 ± 1.73), and for AST it was 1.08–7.91 (1.56 ± 1.29) times. In patients with IHTS compared to those with normal transaminasemia, the age of onset of CD was significantly lower (9.83 ± 3.69 vs. 12.95 ± 4.43 months, p = 0.001), as well as the age of diagnosis (12.97 ± 3.88 vs. 15.47 ± 4.56 months; p = 0.01), while the differences in the other observed parameters were not significant. Conclusions IHTS occurs in almost half of children up to two years old with classical CD. Hypertransaminasemia is in most cases mild and significantly more frequent in patients with earlier clinical expression of the CD.
Published: 2019
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16. Influence of breastfeeding and timing of gluten introduction on the onset of celiac disease in infants

Author: Mladenović Marija, Radlović Nedeljko, Leković Zoran, Vuletić Biljana, Radlović Vladimir, Dučić Siniša, Golubović Zoran, Radlović Jelena, Mahmutović Meho, and Petrović Jasna
Subjects: classic celiac disease, children up to 2 years, breastfeeding, age of gluten introduction, Medicine
Abstract: Introduction/Objective. The classic type of celiac disease (CD) is most common in children under two years of age. The aim of this study was to investigate whether breastfeeding, particularly breastfeeding during gluten introduction, and timing of gluten introduction, influence the onset of CD at this age. Methods. We retrospectively analyzed medical records of 93 children, 40 in the first and 53 in the second year, with a classic CD diagnosed at the University Children’s Hospital, Belgrade between 2000 and 2010. The diagnosis of CD was based on the criteria of the European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) from 1989. Results. Duration of breastfeeding reduced the onset of the CD in the first year p = 0.039 (OR = 1.43 95% CI 1.019–1.899). Also, breastfeeding at the time of gluten introduction significantly delayed the age at diagnosis (F = 1.671, t = 2.39, p = 0.029). The timing of gluten introduction did not affect the age of occurrence of CD in these group of children. Conclusion. Longer breastfeeding, and breastfeeding at the time of gluten introduction, postponed the onset of classic CD in patients up to two years. The association between the occurrence of CD and the time of introduction of gluten in this age group of patients has not been established.
Published: 2019
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17. Frequency, severity and type of anemia in children with classical celiac disease

Author: Radlović Nedeljko, Leković Zoran, Mladenović Marija, Radlović Vladimir, Vuletić Biljana, Dučić Siniša, Golubović Zoran, Nikolić Dejan, Mahmutović Meho, and Petrović-Tepić Snežana
Subjects: classical celiac disease, children, anemia, Medicine
Abstract: Introduction/Objective. Anemia is the most common extraintestinal manifestation of celiac disease (CD) in children. The aim of this study was to determine the frequency, severity and type of anemia in children with a classical CD, as well as the differences between anemic and non-anemic patients in their age, duration of illness, percentile body length or height, percentage of body weight (BW) deviation compared to ideal, and the degree of damage to the small intestine mucosa. Methods. The study was based on a sample of 90 children, 56 females and 34 males, ages 7–90 (18.23 Ѓ} 12.7) months with classical CD. The diagnosis of CD is based on the ESPGHAN criteria from 1990 and 2012, and of anemia on the 2011 WHO reference values. Results. Anemia was found in 47 (52.22%) patients, of which it was mild in 23 cases [hemoglobin (Hb) 100–109 g/L] and moderately severe in 24 (Hb 70–99 g/L), in 34 (72.34%) it was microcytic [mean cell volume (MCV) < 70 fl] and normocytic (MCV 70–87 fl) in 13 patients. Low serum iron levels (< 10.7 μmol/L) were found in 68 (75.56%), and hypoferritinemia (< 16 ng/ml) in 77 (85.56%) patients. Except for a greater deficit of BW in patients with anemia compared to those without anemia (-14.64 ± 9.60 vs. -8.56 ± 11.87%, p < 0.01), differences in other defined features were not significant. Conclusion. Mild or moderate iron deficiency anemia occurs in slightly more than half of children with a classical type CD. In anemic compared to non-anemic patients, there is a significantly higher BW deficit, while differences in other characteristics typical for this type of disease are not significant.
Published: 2019
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18. Isolated dislocation of the pisiform bone in a 10-year-old boy

Author: Dučić Siniša, Bojović Nikola, Radlović Vladimir, Đuričić Goran, and Bukva Bojan
Subjects: dislocation, pisiform, children, Medicine
Abstract: Introduction. Isolated dislocation of the pisiform bone is a very rare condition due to robust ligamentous attachments that stabilize the pisiform to the carpus. This type of injury is usually a result of direct trauma to the ulnar and volar aspect of the wrist. Case outline. We present an isolated dislocation of the pisiform, with no other carpal bone injuries, treated successfully with closed reduction. Diagnosis was based on clinical findings, plain radiographs, and computer tomography examination of the wrist. Elongation and partial rupture of the pisometacarpal ligament was found on magnetic resonance imaging. Conclusion. Fracture and dislocation of the pisiform is an extremely rare injury in children, which could be easily neglected or misdiagnosed. Closed reduction with plaster cast immobilization should always be considered as the first method of treatment in the pediatric population, since the conservative approach provides excellent results.
Published: 2019
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19. Severe painful lower limbs and refusal of the leg reliance as atypical presentation of Gullain Barre syndrome

Author: Stojković Jasna, Petronić Ivana, Nikolić Dejan, Dučić Siniša, Vrgoč Goran, and Bukva Bojan
Subjects: guillain-barre syndrome, acute motor axonal neuropathy, atypical presentation, Medicine
Abstract: Introduction. Guillain–Barre syndrome (GBS) is the most common cause of acute flaccid paralysis in healthy infants and children. Acute motor axonal neuropathy (AMAN) is a type of GBS characterized by motor syndrome with no sensory symptoms. Case outline. Authors describe a six-and-a-half year old girl with atypical clinical presentation of AMAN with severe painful lower limbs and refusal of the leg reliance with typical findings on nerves conduction studies. Conclusion. Despite the nerve conduction study findings, atypical forms of AMAN and GBS are possible. Pain symptoms must be taken very seriously and treated careful by the clinicians.
Published: 2019
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20. Social, clinical and radiological characteristics of physical abuse of children up to 3 years of age hospitalized in a tertiary health institution

Author: Đuričić Goran, Milošević Zorica, Alempijević Đorđe, Radlović Vladimir, Medović Raša, Dučić Siniša, and Golubović Zoran
Subjects: child abuse, children under three years, bone fractures, Medicine
Abstract: Introduction/Objective. Child abuse is a significant public health problem in modern society. Many cases of violence against children remain undetected. Serbia has no official protocols for medical examination of abused children. The aim of the study is an analysis of the social, clinical and radiological characteristics of physical abuse of children under three years of age that required hospital treatment. Methods. This retrospective study included 98 physically injured children admitted to the University Children’s Hospital in the period from 2013 to 2015, with suspected physical abuse. In addition to the history of injuries, complete clinical examinations and standard laboratory analyses were performed in all children, as well as X-ray examination in children with apparent or suspected skeletal injury. Ultrasound examination and computerized tomography or magnetic resonance imaging were performed in selected patients. Final diagnosis of abuse was established by multidisciplinary assessment team. The children were divided into two groups – those with proven and those with suspected abuse. Results. Most of 98 children who were suspected of being abused (92%) were from one or both unemployed parents, 68% were male, 60% were first-born, and 44% younger than one year. Ninety-two percent of the children had skeletal fractures, 19% of whom had two or more fractures. The commonest fracture was a linear skull fracture, which was detected in 51% of the cases. Abuse was confirmed in only five of 98 suspected cases. Conclusion. Among the known social risk factors for abuse of children, the low economic status of the family was the most frequent one in our analyzed sample. The most common injury is a linear skull fracture. A national guideline for medical investigating of abused children is required.
Published: 2017
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21. The Influence of the Q-Angle and Muscle Strength on Idiopathic Anterior Knee Pain in Adolescents

Author: Milovanović, Darko, primary, Begović, Ninoslav, additional, Bukva, Bojan, additional, Dučić, Siniša, additional, Vlahović, Aleksandar, additional, Paunović, Zoran, additional, Kadija, Marko, additional, Topalović, Nikola, additional, and Stijak, Lazar, additional
Published: 2023
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22. A prospective randomised non-blinded comparison of conventional and Dorgan’s crossed pins for paediatric supracondylar humeral fractures

Author: Dučić, Sinisa, Radlović, Vladimir, Bukva, Bojan, Radojičić, Zoran, Vrgoč, Goran, Brkić, Iva, Jaramaz Dučić, Tatjana, Jurdana, Hari, Abramović, Dusan, Bojović, Nikola, and Štefan, Lovro
Published: 2016
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23. Comparison of Negative Pressure Wound Therapy (NPWT) and Classical Wet to Moist Dressing (WtM) in the Treatment of Complicated Extremity Wounds in Children

Author: Slavkovic, Milan, primary, Zivanovic, Dragoljub, additional, Dučić, Siniša, additional, Lasić, Valentina, additional, Bukvić, Nado, additional, Nikolić, Harry, additional, and Martinović, Vlatka, additional
Published: 2023
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24. Clinical approach to children with knee overuse syndromes

Author: Dučić, Siniša, primary, Milanović, Filip, additional, Bukva, Bojan, additional, Đuričić, Goran, additional, and Nikolić, Dejan, additional
Published: 2023
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25. Complications in leg lengthening using an Ilizarov external fixator and intramedullary alignment in children: comparative study during a fourteen-year period

Author: Bukva, Bojan, Vrgoč, Goran, Rakovac, Ivan, Dučić, Siniša, Sindik, Joško, Čoklo, Miran, Marinović, Marin, and Bakota, Bore
Published: 2015
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26. Femoral neck fractures in children and the role of early hip decompression in final outcome

Author: Bukva, Bojan, Abramović, Dušan, Vrgoč, Goran, Marinović, Marin, Bakota, Bore, Dučić, Siniša, Miškulin, Mladen, Brdar, Radivoj, Čoklo, Miran, and Gulan, Gordan
Published: 2015
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27. Displaced supracondylar humeral fractures in children: Comparison of three treatment approaches

Author: Dučić Siniša, Bumbaširević Marko, Radlović Vladimir, Nikić Petar, Bukumirić Zoran, Brdar Radivoj, Radojičić Zoran, Bukva Bojan, Abramović Dušan, and Jaramaz-Dučić Tatjana
Subjects: supracondylar humeral fractures, closed reduction, open reduction, percutaneous pinning, treatment complications, functional outcome, Medicine
Abstract: Introduction. Closed reduction and percutaneous pinning are the most widely used treatment options for displaced supracondylar humerus fractures in children, but there is still no consensus concerning the most preferred technique in injuries of the extension type. Objective. The aim of this study was to compare three common orthopaedic procedures in the treatment of displaced extension type supracondylar humerus fractures in children. Methods. Total of 93 consecutive patients (66 boys and 27 girls) referred to our hospital with Gartland type II or III extension supracondylar humeral fractures were prospectively included in the study over a six-year period. At initial presentation 48 patients were classified as Gartland type II and 45 as Gartland type III fractures. The patients were subdivided into three groups based on the following treatment modality: closed reduction with percutaneous pinning, open reduction with Kirschner wires (K-wires) fixation, and closed reduction with cast immobilisation. The treatment outcome and clinical characteristics were compared among groups, as well as evaluated using Flynn’s criteria. Results. Excellent clinical outcome was reported in 70.3% of patients treated with closed reduction with percutaneous pinning and in 64.7% of patients treated with open reduction with K-wire fixation. The outcome was significantly worse in children treated with closed reduction and cast immobilisation alone, as excellent outcome is achieved in just 36.4% of cases (p=0.011). Conclusion. Closed reduction with percutaneous pinning is the method of choice in the treatment of displaced pediatric supracondylar humeral fracture, while open reduction with K-wire fixation is as a good alternative in cases with clear indications. [Projekat Ministarstva nauke Republike Srbije, br. 175095]
Published: 2016
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28. Paediatric T-condylar fractures of the humerus: Clinical experience and outcomes in 19 cases

Author: Ducic, Sinisa, Bumbasirevic, Marko, Brdar, Radivoj, Stojanovic, Borko, and Djordjevic, Miroslav
Published: 2014
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29. Alpha-1-antitrypsin deficiency in children: Clinical characteristics and diagnosis

Author: Radlović Nedeljko, Leković Zoran, Radlović Vladimir, Simić Dušica, Topić Aleksandra, Ristić Dragana, Dučić Siniša, and Baletić Anđelo
Subjects: alpha-1-antitrypsin deficiency (AATD), infant, clinical manifestations, Medicine
Abstract: Introduction. Alpha-1-antitrypsin deficiency (AATD) is a relatively rare and clinically very heterogeneous autosomal recessive disorder. Objective. Presentation of clinical characteristics of AATD in the first months after birth, as well as the significance of testing brothers and sisters for its presence. Methods. Objectives of the study were analyzed on a sample of eight children (four male and four female, aged 63 months (mean14.81±23.96 months; range 1-63 months) with AATD confirmed based on its low serum value and pathological phenotype. Results. Of the total of eight patients, six manifested cholestasis syndrome (three male and three female, mean age 2.25±1.37 months; range 1-4.5 months), while two patients, a 3.5-year-old girl and a 5.25-year-old boy, were without symptoms and clinical-laboratory signs of the disease, disclosed during family testing. Serum alpha-1-antitrypsin level rated 0.30-0.66 g/L (0.37±0.12), among which seven were with ZZ phenotype 0.30-0.39 (0.33±0.04), and in a boy with FZ the phenotype was disclosed on family screening, 0.66 g/L. In the group of patients with cholestasis syndrome (serum GTT 444.80±203.15 U/L; range 201-676 U/L), three had mild to moderate hepatomegaly, one had longitudinal growth delay (
Published: 2014
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30. X-linked hypophosphatemic rickets: Case report

Author: Radlović Vladimir, Smoljanić Željko, Radlović Nedeljko, Leković Zoran, Ristić Dragana, Dučić Siniša, and Pavićević Polina
Subjects: X-linked hypophosphatemic rickets, diagnostics, therapy, Medicine
Abstract: Introduction. X-linked hypophosphatemic rickets (XLHR) is a dominant inherited disease caused by isolated renal phosphate wasting and impairment of vitamin D activation. We present a girl with X-linked hypophosphatemic rickets (XLHR) as a consequence of de novo mutation in the PHEX gene. Case Outline. A 2.2-year-old girl presented with prominent lower limb rachitic deformity, waddling gait and disproportionate short stature (79 cm, A (p.G579R) (exon 17), XLHR was diagnosed. Analysis of the parental PHEX gene did not show the abnormality, which indicated that the child’s XLHR was caused by de novo mutation of this gene. Conclusion. Identification of genetic defects is exceptionally significant for diagnosis and differential diagnosis of hereditary HR.
Published: 2014
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31. Application of the ommaya reservoir in the treatment of hydrocephalus in prematurely born children: Correlation with animal results

Author: Mihajlović Miljan, Mrdak Milan, Radlović Vladimir, Nikolić Igor, Rakić Miodrag, Repac Nikola, Antunović Vaso, Janićijević Aleksandar, Šćepanović Vuk, Tasić Goran, and Dučić Siniša
Subjects: prematurely born child, intraventricular hemorrhage, hydrocephalus, treatment, Medicine
Abstract: Introduction. Intraventricular hemorrhage occurs in almost one fifth of prematurely born children. Due to present complications, such as hydrocephalus and neurological deficit, it endangers the child’s life, therefore there is the need for understanding and prevent risk factors as well as the need for finding most optimal methods of treatment. Objective. The aim of the study was to point out the current therapeutic modalities of the treatment of posthemorrhagic hydrocephalus in prematurely born children. Methods. The study included 60 patients divided into two groups of 30 patients treated at the University Children’s Hospital of Belgrade in the period 2003-2008. Results. Treatment outcome of the control group of patients treated by standard methods was influenced by gestational age (p=0.024), head circumference on birth (p=0.043), body mass on birth (p=0.006), Apgar score on birth (p
Published: 2013
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32. Pseudoachondroplasia: A case report

Author: Radlović Vladimir, Smoljanić Željko, Radlović Nedeljko, Jakovljević Miroslav, Leković Zoran, Dučić Siniša, and Pavićević Polina
Subjects: pseudoachondroplasia, rhizomelic dwarfism, osteochondrodysplasias, Medicine
Abstract: Introduction. Pseudoachondroplasia (PSACH) is an autosomal dominant osteochondrodysplasia due to mutations in the gene encoding cartilage oligomeric matrix protein. It is characterized by rhizomelic dwarfism, limb and vertebral deformity, joint laxity and early onset osteoarthrosis. We present the girl with the early expressed and severe PSACH born to clinically and radiographically unaffected parents. Case Outline. A 6.5-year-old girl presented with short-limbed dwarfism (body height 79.5 cm,
Published: 2013
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33. Incidence of penile curvature in various forms of hypospadias

Author: Đorđević Miroslav, Stojanović Borko, Stojsavljević Miodrag, Dučić Siniša, Bižić Marta, and Majstorović Marko
Subjects: hypospadias, curvature, penis, incidence, Medicine
Abstract: Introduction. Hypospadias is a congenital anomaly of the penis, characterised by ectopically positioned urethral meatus and associated anomalies (cryptorchidism, inguinal hernia, penile curvature). Proximal forms of hypospadias, as severe cases, are particularly accompanied by penile curvature (chordee). Distal types are considered to be mild degrees. Objective. To determine the incidence of congenital curvature within various forms of hypospadias in order to signify preoperative and intraoperative diagnosis of chordee as a part of hypospadias repair. Methods. The total of 454 patients with hypospadias were treated surgically in a five-year period (2001-2006.) at the University Children's Hospital of Belgrade. The patients were divided into two groups according to the surgeon who had treated them. Only the first group of patients was tested for chordee as a part of standard procedure and complete treatment. In both groups we analyzed the number of patients treated for penile curvature within various types of hypospadias. We also compared scores in the two groups using Fisher test and χ2-test. Results. Scanning retrospective, 104 cases (22.9%) of diagnosed and surgically corrected chordee were determined. In 31.6% of patients from the first group and 11.6% of patients from the second group we diagnosed and corrected some form of penile curvature was. Chordee was significantly more frequent in the first group, regarding hypospadias in general (p
Published: 2009
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34. Computational analysis of MRIs predicts osteosarcoma chemoresponsiveness

Author: Djuričić, Goran J, primary, Rajković, Nemanja, additional, Milošević, Nebojša, additional, Sopta, Jelena P, additional, Borić, Igor, additional, Dučić, Siniša, additional, Apostolović, Milan, additional, and Radulovic, Marko, additional
Published: 2021
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35. Sacrospinous Ligament Fixation for Neovaginal Prolapse Prevention in Male-to-Female Surgery

Author: Stanojevic, Dusan S., Djordjevic, Miroslav L., Milosevic, Aleksandar, Sansalone, Salvatore, Slavkovic, Zoran, Ducic, Sinisa, Vujovic, Svetlana, and Perovic, Sava V.
Published: 2007
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36. Social, clinical, and radiological characteristics of physical abuse of children under three years of age hospitalized in a tertiary health institution

Author: Đurišić Goran, Milošević Zorica, Alempijević Đorđe, Radlović Vladimir, Medović Raša, Dučić Siniša, and Golubović Zoran
Subjects: children under three years, child abuse, bone fractures
Abstract: Introduction/Objective. Child abuse is a significant public health problem in modern society. Many cases of violence against children remain undetected. Serbia has no official protocols for medical examination of abused children. The aim of the study is an analysis of the social, clinical and radiological characteristics of physical abuse of children under three years of age that required hospital treatment. Methods. This retrospective study included 98 physically injured children admitted to the University Children’s Hospital in the period from 2013 to 2015, with suspected physical abuse. In addition to the history of injuries, complete clinical examinations and standard laboratory analyses were performed in all children, as well as X-ray examination in children with an apparent or suspected skeletal injury. Ultrasound examination and computerized tomography or magnetic resonance imaging were performed in selected patients. Final diagnosis of abuse was established by multidisciplinary assessment team. The children were divided into two groups – those with proven and those with suspected abuse. Results Most of 98 children who were suspected of being abused (92%) were from one or both unemployed parents, 68% were male, 60% were first-born, and 44% younger than one year. Ninety-two percent of the children had skeletal fractures, 19% of whom had two or more fractures. The commonest fracture was a linear skull fracture, which was detected in 51% of the cases. Abuse was confirmed in only five of 98 suspected cases. Conclusion. Among the known social risk factors for abuse of children, the low economic status of the family was the most frequent one in our analyzed sample. The most common injury is a linear skull fracture. A national guideline for medical investigating of abused children is required. &nbsp
Published: 2017

37. The Safety and Efficacy of the Continuous Peripheral Nerve Block in Postoperative Analgesia of Pediatric Patients

Author: Simić, Dušica, primary, Stević, Marija, additional, Stanković, Zorana, additional, Simić, Irena, additional, Dučić, Siniša, additional, Petrov, Ivana, additional, and Milenović, Miodrag, additional
Published: 2018
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38. TREATMENT OF UNICAMERAL BONE CYSTS IN CHILDREN: A COMPARATIVE STUDY.

Author: Bukva, Bojan, Vrgoč, Goran, Abramović, Dušan, Dučić, Siniša, Brkić, Iva, and Čengić, Tomislav
Published: 2019
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39. Isolated hypertransaminasemia in children up to two years old with classical celiac disease.

Author: Radlović, Nedeljko, Leković, Zoran, Mladenović, Marija, Radlović, Vladimir, Vuletić, Biljana, Dučić, Siniša, Golubović, Zoran, Mahmutović, Meho, and Petrović-Tepić, Snežana
Published: 2019
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40. Treatment of slipped capital femoral epiphysis -- a comparative study during a twelve-year period.

Author: Bukva, Bojan, Dučić, Siniša, Radlović, Vladimir, Vrgoč, Goran, Krivokapić, Branislav, Jelaska, Igor, and Mandić-Jelaska, Petra
Published: 2019
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41. Displaced supracondylar humeral fractures in children: Comparison of three treatment approaches

Author: Dučić, Siniša, Bumbaširević, Marko, Radlović, Vladimir, Nikić, Petar, Bukumirić, Zoran, Brdar, Radivoj, Radojičić, Zoran, Bukva, Bojan, Abramović, Dušan, Jaramaz-Ducić, Tatjana, Dučić, Siniša, Bumbaširević, Marko, Radlović, Vladimir, Nikić, Petar, Bukumirić, Zoran, Brdar, Radivoj, Radojičić, Zoran, Bukva, Bojan, Abramović, Dušan, and Jaramaz-Ducić, Tatjana
Abstract: Introduction Closed reduction and percutaneous pinning are the most widely used treatment options for displaced supracondylar humerus fractures in children, but there is still no consensus concerning the most preferred technique in injuries of the extension type. Objective The aim of this study was to compare three common orthopaedic procedures in the treatment of displaced extension type supracondylar humerus fractures in children. Methods Total of 93 consecutive patients (66 boys and 27 girls) referred to our hospital with Gartland type II or III extension supracondylar humeral fractures were prospectively included in the study over a six-year period. At initial presentation 48 patients were classified as Gartland type II and 45 as Gartland type III fractures. The patients were subdivided into three groups based on the following treatment modality: closed reduction with percutaneous pinning, open reduction with Kirschner wires (K-wires) fixation, and closed reduction with cast immobilisation. The treatment outcome and clinical characteristics were compared among groups, as well as evaluated using Flynn's criteria. Results Excellent clinical outcome was reported in 70.3% of patients treated with closed reduction with percutaneous pinning and in 64.7% of patients treated with open reduction with K-wire fixation. The outcome was significantly worse in children treated with closed reduction and cast immobilisation alone, as excellent outcome is achieved in just 36.4% of cases (p=0.011). Conclusion Closed reduction with percutaneous pinning is the method of choice in the treatment of displaced pediatric supracondylar humeral fracture, while open reduction with K-wire fixation is as a good alternative in cases with clear indications.
Published: 2016

42. Značaj perkutane fiksacije fragmenata kod dislociranih suprakondilarnih preloma humerusa u dečjem uzrastu

Author: Dučić, Siniša V., Bumbaširević, Marko, Lešić, Aleksandar, Vučetić, Čedomir, and Mitković, Milorad
Subjects: supracondylar humerus fracture, children, intercondylar fracture, perkutana fiksacija, deca, suprakondilarni prelom humerusa, interkondilarni prelom, percutaneous fixation
Abstract: Uvod: Suprakondilarni prelomi su najčešći prelomi lakta u dečjem uzrastu i spadaju u druge po učestalosti prelome kod dece (16,6%), a po lokalizaciji ovom tipu preloma pripada od 50 do 70% svih preloma lakta kod dece uzrasta do 10 godina. Najčešće nastaju padom na ispruženu ruku. Modaliteti lečenja dislociranih suprakondilarnih preloma humerusa kod dece uglavnom se svode na tri metode: ortopedsku repoziciju sa gipsanom imobilizacijom, ortopedsku repoziciju praćenu perkutanom fiksacijom dislociranih fragmenata (perkutanu fiksaciju) i hiruršku repoziciju sa stabilizacijom Kiršnerovim iglama. Mada još uvek nije postignut konsenzus izmeĎu dečjih ortopeda o izabranom metodu lečenja, perkutana fiksacija je najčešće primenjivana u lečenju dislociranih suprakondilarnih preloma kod dece. Pored toga različiti su stavovi o stepenu hitnosti lečenja suprakondilarnih preloma. Pristalice ranog lečenja (unutar 12 sati od povreĎivanja) ističu bolje rezultate lečenja, manji broj komplikacija lečenja kao i lakše izvoĎenje ortopedske repozicije. Cilj: ovog istraživanja je uporeĎivanje tri najčešće korišćena metoda lečenja suprakondilarnih preloma humerusa kod dece i potvrĎivanje hipoteze o perkutanoj fiksaciji kao metodi izbora u lečenju ovih preloma, kao i da se utvrdi da li su rezultati lečenja bolji kod pacijenata lečenih unutar 12 sati od povreĎivanja (rano lečenje) u odnosu na pacijente lečene posle 12 sati od povreĎivanja (odgoĎeno lečenje), kao i da li odgoĎeno lečenje utiče na povećanje stope konverzija ortopedske u hiruršku repoziciju. Materijal i metode: U retrospektivno-prospektivnoj studiji je analizirano 123 pacijenta sa suprakondilarnim prelomom humerusa tip II i tip III po Wilkinsonovoj modifikaciji Gartlandove klasifikacije koji su lečeni na Univerzitetskoj dečijoj klinici, kroz sedmogodišnji period (od 2006. do 2012. godine). Lečeno je 86 dečaka i 37 devojčica, uzrasta 1,5-11,4 godine (srednja vrednost 6,5 godina). Suprakondilarni prelom tip II dijagnostifikovan je kod 57, a tip III kod 66 pacijenata. Na osnovu ortopedskog metoda lečenja pacijenti su podeljeni u tri grupe: pacijenti lečeni ortopedskom repozicijom sa gipsanom imobilizacijom, perkutanom fiksacijom i hirurškom repozicijom sa stabilizacijom Kiršnerovim iglama. Rezultati: lečenja su procenjivani i uporeĎivani izmeĎu različitih grupa na osnovu Flynnovih kriterijuma, tj. kod pacijenata je procenjivan posebno funkcionalni, a posebno kozmetski rezultat lečenja, zato što kod nekih pacijenata funkcionalni rezultat može biti dobar, a loš kozmetski i obrnuto... Introduction: Supracondylar fractures are the most common elbow fractures in children and the second most common fractures in children, overall (16.6%). Regarding the localization 50 to 70% of all elbow fractures in children, up to 10 years old, are classified as this type of fracture. They most frequently occur as a result of a fall onto an extended hand. Treatment modes of dislocated supracondylar humerus fractures in children usually comprise one of three methods: closed reduction with cast immobilization, closed reduction with percutaneous fixation of dislocated fragments (percutaneous pinning) and open reduction with Kirschner wire stabilization. Although a consensus on the treatment option of choice has not yet been reached among pediatric orthopaedists, percutaneous fixation is the most frequently used method in the treatment of dislocated supracondylar fractures in children. In addition, opinions diverge on the level of urgency of treating supracondylar fractures. Supporters of an early treatment (within 12 hours from injury) emphasize the better treatment results, fewer complications and easier closed reduction. The aim: of this research was to compare the three most commonly used treatment methods for supracondylar humerus fractures in children, to examine the hypothesis on percutaneous fixation as the method of choice in the treatment of these fractures, as well as to determine whether better treatment results are achieved in patients treated within 12 hours from injury (early treatment) compared to those treated after more than 12 hours (delayed treatment) and to investigate whether delayed treatment increases the rate of conversion of closed to open reduction. Materials and methods: A retrospective-prospective study analyzed the treatment results for 123 patients with supracondylar humerus fractures type II and III according to Wilkins's modification of the Gartland classification. The patients were treated at the University Children's Hospital, during a seven-year period (form 2006 to 2012). A total of 86 boys and 37 girls were treated, aged 1.5-11.4 years (mean: 6.5 years). Supracondylar fracture type II was diagnosed in 57 and type III in 66 patients. Based on the orthopaedic treatment method, the patients were classified in three groups: patients treated by closed reduction with cast immobilization, by percutaneous fixation and by open reduction with Kirschner wire stabilization...
Published: 2014

43. Treatment of Congenital Leg Length Discrepancies in Children Using an Ilizarov External Fixator: A Comparative Study

Author: Bukva, Bojan, Vrgoč, Goran, Brdar, Radivoj, Dučić, Siniša, Gulan, Gordan, and Jurdana, Hari
Subjects: Adult, leg length discrepancy, Ilizarov external fi xator, children, Adolescent, External Fixators, Leg Length Inequality, Young Adult, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Ortopedija, Child, Preschool, Humans, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Orthopedics, Child
Abstract: The purpose of this study was to evaluate the infl uence of intramedullary (IM) alignment used in combination with an Ilizarov external fi xation on the healing index (HI) and lengthening index (LI) in the treatment of congenital leg length discrepancies (LLD). This study included 35 patients aged from 3.5 to 19 (average age 10.73) who underwent the egalisation procedure using an Ilizarov external fi xator. We compared the duration of the external fi xator application, LLD, HI and LI between two groups of children: children in Group I underwent limb lengthening by the conventional llizarov technique using an Ilizarov external fi xator alone, and children in Group II underwent a combination of Ilizarov technique and intramedullary alignment with two Kirschner wires, introduced through two mini-incisions. We found signifi cant differences between the two groups of patients for duration of external fi xator application and HI. Patients with congenital LLD treated with combined method of treatment had benefi t from intramedullary alignment due to its better outcome.
Published: 2014

44. Recurrent aphthous stomatitis as the only clinical sign of celiac disease in an obese adolescent - case report and literature review.

Author: Mandić, Jelena, Radlović, Nedeljko, Leković, Zoran, Radlović, Vladimir, Dučić, Siniša, Nikolić, Dejan, and Jovičić, Olivera
Published: 2020
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45. Alpha-1-antitrypsin deficiency in children: Clinical characteristics and diagnosis

Author: Radlović, Nedeljko, Radlović, Nedeljko, Leković, Zoran, Radlović, Vladimir, Simić, Dušica, Topić, Aleksandra, Ristić, Dragana, Dučić, Siniša, Baletić, Anđelo, Radlović, Nedeljko, Radlović, Nedeljko, Leković, Zoran, Radlović, Vladimir, Simić, Dušica, Topić, Aleksandra, Ristić, Dragana, Dučić, Siniša, and Baletić, Anđelo
Abstract: Introduction Alpha-1-antitrypsin deficiency (AATD) is a relatively rare and clinically very heterogeneous autosomal recessive disorder. Objective Presentation of clinical characteristics of AATD in the first months after birth, as well as the significance of testing brothers and sisters for its presence. Methods Objectives of the study were analyzed on a sample of eight children (four male and four female, aged 63 months (mean14.81±23.96 months; range 1-63 months) with AATD confirmed based on its low serum value and pathological phenotype. Results Of the total of eight patients, six manifested cholestasis syndrome (three male and three female, mean age 2.25±1.37 months; range 1-4.5 months), while two patients, a 3.5-year-old girl and a 5.25-year-old boy, were without symptoms and clinical-laboratory signs of the disease, disclosed during family testing. Serum alpha-1-antitrypsin level rated 0.30-0.66 g/L (0.37±0.12), among which seven were with ZZ phenotype 0.30-0.39 (0.33±0.04), and in a boy with FZ the phenotype was disclosed on family screening, 0.66 g/L. In the group of patients with cholestasis syndrome (serum GTT 444.80±203.15 U/L; range 201-676 U/L), three had mild to moderate hepatomegaly, one had longitudinal growth delay ( lt P3; -10.50%) and two had icterus with conjugated hyperbilirubinemia (92 and 109 μmol/L) and prolonged prothrombin time (PT 14.8 and 17 sec). All children with cholestasis syndrome also had hypertransaminasemia (ALT 80.83±33 U/L; range 37-124 U/L and AST 116.67±62.82 U/L; range 58-230 U/L). Conclusion Cholestasis syndrome represents a basic manifestation of AATD in the first months after birth, while early testing of brothers and sisters enables early disclosure and adequate treatment of the subclinical forms of the disease., Uvod Nedostatak alfa-1 antitripsina (AATD) je relativno redak i klinički veoma heterogen autozomno recesivni poremećaj. Cilj rada Cilj rada je bio da se prikažu kliničke odlike AATD u prvim mesecima po rođenju, kao i značaj testiranja braće i sestara na ovaj poremećaj. Metode rada Ispitano je osmoro dece (četiri dečaka i četiri devojčice) uzrasta od mesec dana do 63 meseca (prosečno 14,81±23,96 meseci) sa AATD, koji je dokazan na osnovu niske vrednosti alfa- 1 antitripsina u serumu i patološkog fenotipa. Rezultati Kod šestoro dece (tri dečaka i tri devojčice) uzrasta od mesec dana do četiri i po meseca (prosečno 2,25±1,37 meseci) ispoljio se holestazni sindrom, dok su dva deteta (troipogodišnja devojčica i dečak uzrasta od 5,25 godina) bila bez simptoma i kliničko- laboratorijskih znakova AATD, ali je bolest otkrivena u sklopu porodičnog testiranja. Nivo alfa- 1 antitripsina u serumu bio je 0,30-0,66 g/l (prosečno 0,37±0,12 g/l), pri čemu kod sedmoro dece sa ZZ fenotipom 0,30-0,39 g/l (prosečno 0,33±0,04 g/l), a kod dečaka sa FZ fenotipom, otkrivenog porodičnim skriningom, 0,66 g/l. U grupi bolesnika sa holestaznim sindromom (nivo GGT u serumu bio je u proseku 444,80±203,15 IU/l; raspon 201-676 IU/l), kod tri deteta je utvrđena blaga do umerena hepatomegalija, kod jednog deteta je uočen zastoj u longitudinalnom rastu ( lt P3; -10,50%), dok je kod dvoje dece zabeležen ikterus sa konjugovanom hiperbilirubinemijom (92 i 109 μmol/l) i produženim parcijalnim vremenom (14,8 i 17 s). Kod sve dece s holestaznim sindromom utvrđena je i hipertransaminazemija s vrednostima ALT 80,83±33 IU/l (raspon 37-124 IU/l) i AST 116,67±62,82 IU/l (raspon 58-230 IU/l). Zaključak Holestazni sindrom je osnovna manifestacija AATD u prvim mesecima po rođenju deteta, dok testiranje braće i sestara obolelih omogućava rano otkrivanje i odgovarajuće lečenje supkliničkih oblika bolesti.
Published: 2014

46. Značaj perkutane fiksacije fragmenata kod dislociranih suprakondilarnih preloma humerusa u dečjem uzrastu

Author: Bumbaširević, Marko, Lešić, Aleksandar, Vučetić, Čedomir, Mitković, Milorad, Dučić, Siniša V., Bumbaširević, Marko, Lešić, Aleksandar, Vučetić, Čedomir, Mitković, Milorad, and Dučić, Siniša V.
Abstract: Uvod: Suprakondilarni prelomi su najčešći prelomi lakta u dečjem uzrastu i spadaju u druge po učestalosti prelome kod dece (16,6%), a po lokalizaciji ovom tipu preloma pripada od 50 do 70% svih preloma lakta kod dece uzrasta do 10 godina. Najčešće nastaju padom na ispruženu ruku. Modaliteti lečenja dislociranih suprakondilarnih preloma humerusa kod dece uglavnom se svode na tri metode: ortopedsku repoziciju sa gipsanom imobilizacijom, ortopedsku repoziciju praćenu perkutanom fiksacijom dislociranih fragmenata (perkutanu fiksaciju) i hiruršku repoziciju sa stabilizacijom Kiršnerovim iglama. Mada još uvek nije postignut konsenzus izmeĎu dečjih ortopeda o izabranom metodu lečenja, perkutana fiksacija je najčešće primenjivana u lečenju dislociranih suprakondilarnih preloma kod dece. Pored toga različiti su stavovi o stepenu hitnosti lečenja suprakondilarnih preloma. Pristalice ranog lečenja (unutar 12 sati od povreĎivanja) ističu bolje rezultate lečenja, manji broj komplikacija lečenja kao i lakše izvoĎenje ortopedske repozicije. Cilj: ovog istraživanja je uporeĎivanje tri najčešće korišćena metoda lečenja suprakondilarnih preloma humerusa kod dece i potvrĎivanje hipoteze o perkutanoj fiksaciji kao metodi izbora u lečenju ovih preloma, kao i da se utvrdi da li su rezultati lečenja bolji kod pacijenata lečenih unutar 12 sati od povreĎivanja (rano lečenje) u odnosu na pacijente lečene posle 12 sati od povreĎivanja (odgoĎeno lečenje), kao i da li odgoĎeno lečenje utiče na povećanje stope konverzija ortopedske u hiruršku repoziciju. Materijal i metode: U retrospektivno-prospektivnoj studiji je analizirano 123 pacijenta sa suprakondilarnim prelomom humerusa tip II i tip III po Wilkinsonovoj modifikaciji Gartlandove klasifikacije koji su lečeni na Univerzitetskoj dečijoj klinici, kroz sedmogodišnji period (od 2006. do 2012. godine). Lečeno je 86 dečaka i 37 devojčica, uzrasta 1,5-11,4 godine (srednja vrednost 6,5 godina). Suprakondilarni prelom tip II dijagnostifikovan je kod, Introduction: Supracondylar fractures are the most common elbow fractures in children and the second most common fractures in children, overall (16.6%). Regarding the localization 50 to 70% of all elbow fractures in children, up to 10 years old, are classified as this type of fracture. They most frequently occur as a result of a fall onto an extended hand. Treatment modes of dislocated supracondylar humerus fractures in children usually comprise one of three methods: closed reduction with cast immobilization, closed reduction with percutaneous fixation of dislocated fragments (percutaneous pinning) and open reduction with Kirschner wire stabilization. Although a consensus on the treatment option of choice has not yet been reached among pediatric orthopaedists, percutaneous fixation is the most frequently used method in the treatment of dislocated supracondylar fractures in children. In addition, opinions diverge on the level of urgency of treating supracondylar fractures. Supporters of an early treatment (within 12 hours from injury) emphasize the better treatment results, fewer complications and easier closed reduction. The aim: of this research was to compare the three most commonly used treatment methods for supracondylar humerus fractures in children, to examine the hypothesis on percutaneous fixation as the method of choice in the treatment of these fractures, as well as to determine whether better treatment results are achieved in patients treated within 12 hours from injury (early treatment) compared to those treated after more than 12 hours (delayed treatment) and to investigate whether delayed treatment increases the rate of conversion of closed to open reduction. Materials and methods: A retrospective-prospective study analyzed the treatment results for 123 patients with supracondylar humerus fractures type II and III according to Wilkins's modification of the Gartland classification. The patients were treated at the University Children's Hospital, during
Published: 2014

47. Social, clinical, and radiological characteristics of physical abuse of children under three years of age hospitalized in a tertiary health institution.

Author: Đuričić, Goran, Milošević, Zorica, Alempijević, Đorđe, Radlović, Vladimir, Medović, Raša, Dučić, Siniša, and Golubović, Zoran
Published: 2017
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48. Familiar case of Larsen syndrome.

Author: Cerovac, Nataša, čuturilo, Goran, and Dučić, Siniša
Abstract: Copyright of Acta Chirurgica Iugoslavica is the property of Association of Yugoslav Surgeons and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Published: 2014
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49. Comparative Analysis of the Animal Model and Results of the Clinical Research of the Aneurysm Inclination Angle as the Predisposing Factor for the Occurrence of Rupture.

Author: Nikolić, Igor, Tasić, Goran, Antunović, Vaso, Rakić, Miodrag, Mihajlović, Miljan, Joković, Miloš, Stojisavljević, Miodrag, Kojić, Zvezdana, Radlović, Vladimir, Djurović, Branko, and Dučić, Siniša
Published: 2013
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50. Procena uticaja sociodemografskih faktora, zdravstvenih faktora i fizičke aktivnosti na razvoj deformiteta kičmenog stuba kod dece

Author: Lazić, Irena, Sinđić-Antunović, Sanja, Srejović, Ivan, Dučić, Siniša, and Grajić, Mirko
Subjects: physical activity, spinal deformities, children, fizička aktivnost, deformiteti kičmenog stuba, deca
Abstract: SAŽETAK Uslovi života, nagli rast i razvoj, porodična opterećen i fizička aktivnost utiču na pojavu deformiteta kičmenog stuba kod dece u razvojnom periodu. Do sada objavljeni literaturni podaci, odnose se uglavnom na uticaj pojedinačnih faktora rasta i razvoja, pojedinačnih uslova života, sociodemografske uslovljenosti, porodičnog opterećenja i slično. Cilj ove disertacije je da se ispita ukupan značaj sociodemografskih faktora, zdravstvenih faktora i fizičke aktivnosti, kao i njihova međusobna uslovljenost, za nastanak deformiteta kičmenog stuba kod dece u razvojnom periodu. Istraživanje je sprovedeno po tipu opservacione, kliničke studije u periodu od 2016 - 2018. godine. Učesnici studije su deca sa deformitetima kičme, koja su prvi put pregledana od strane fizijatra i dečjeg hirurga. Uzorak je obuhvatio 100 dece sa deformitetima kičme, uzrasta 7-16 godina. Kontrolnu grupu je činilo 100 dece bez deformiteta kičme. Skolioza je najčešći deformitet kičmenog stuba, zastupljen u ispitivanoj seriji u oko 67% (r=0,0006) dece. Ispitanici obe grupe nisu se bitno razlikovali prema polu. Deca u grupi sa deformitetima kičmenog stuba bila su statistički značajno starijeg uzrasta (11,5±3,1 vs.10,4±3,1god, r=0.016), povećane telesne težine (43,9±16,0 vs.39,3±16,6 kg, r=0,046) i visine (151,7±17,2 vs.145,8±18,2 cm, r=0,019) i ređe su se bavila slobodnim fizičkim aktivnostima (81,0% vs.92,0%, r=0,001). Deca iz grupe sa deformitetima kičme su značajno manje uključena u fizičke aktivnosti u odnosu na kontrolnu grupu ispitanika bez deformiteta kičme, ali nema značajne razlike u učestalosti i trajanju vremena provedenog u fizičkim aktivnostima tokom nedelje, kao ni u pogledu vrste i zastupljenosti različitih sportova. Za decu je važno da se bave fizičkim aktivnostima, rekreativno, a prema našem istraživanju, najmanje 3 puta, a ukupno 3 sata, nedeljno. ABSTRACT Living conditions, sudden growth and development, family load and physical activity affect the occurrence of spinal deformities in children in the developmental period. The literature data, published so far, refer mainly to the influence of individual factors of development and growth, individual living conditions, socio-demographic conditioning, family burden etc. The aim of this dissertation is to examine the overall importance of sociodemographic factors, health factors and physical activity, as well as their interdependence, for the occurrence of spinal deformities in children in the developmental period. The research was conducted as a type of observational, clinical study in the period from 2016 to 2018. The participants in the study were children with spinal deformities, who were examined for the first time by a physiatrist and a pediatric surgeon. The sample included 100 children with spinal deformities, aged 7-16 years. The control group consisted of 100 children without spinal deformity. Scoliosis is the most common spinal deformity, present in the examined series in about 67% (p=0,0006) of children. Respondents in both groups did not differ significantly by gender. Children in the group with spinal deformities were statistically significantly older (11,5 ± 3,1 vs.10,4 ± 3,1 years, p=0,016), with increased body weight (43,9±16,0 vs.39,3±16,6 kg, p=0,046) and height (151,7±17,2 vs.145,8±18,2 cm, p=0,019) and less often engaged in free physical activities (81,0% vs.92,0%, p=0,001). Children from the group with spinal deformities were significantly less involved in physical activities compared to the control group of respondents, but there was no significant difference in the frequency and duration of time spent in physical activities during the week, nor in the type and prevalence of different sports. It is important for children to engage in physical activities, recreationally, and according to our research, at least 3 times, and a total of 3 hours, a week.
Published: 2022

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