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135 results on '"Du, Lian-fang"'

13. Contrast-enhanced ultrasound as a valuable imaging modality for characterizing testicular lesions.

Author

Yu, Jie, Jiang, Xin-Hui, Du, Lian-Fang, Bai, Min, Li, Zhao-Jun, Shi, Qiu-Sheng, Jiang, Qi, and Li, Fan

Abstract

Contrast-enhanced ultrasound (CEUS) is a new form of ultrasound (US) that can dynamically display microvessels in a highly sensitive manner. The purpose of this study was to investigate the efficacy of CEUS for characterizing testicular lesions in comparison with conventional US. Forty-seven patients with testicular lesions were enrolled. The histopathology results revealed that 31 cases were neoplastic (11 cases of seminomas, 8 nonseminomatous germ cell tumors, 8 lymphomas, 2 Leydig cell tumors, and 2 nonspecific tumors), and 16 cases were nonneoplastic (8 cases of infarctions, 3 epidermoid cysts, and 5 inflammation). The indicators of shallow lobulated morphology and cystic-solid echogenicity on conventional US were suggestive of germ cell tumors. More indicators on CEUS were found to be useful for characterizing testicular lesions. All the neoplastic lesions showed hyperenhancement on CEUS. Moreover, germ cell tumors presented with heterogeneous enhancement (73.7%, 14/19), a twisted blood vessel pattern, rapid wash-in and wash-out, and peripheral rim hyperenhancement signs. Lymphoma was characterized by nonbranching linear vessel patterns (87.5%, 7/8), rapid wash-in and slow wash-out. In nonneoplastic lesions, infarction and epidermoid cysts showed no enhancement, and abscesses were observed with marginal irregular enhancement. The sensitivity, specificity, and accuracy of CEUS for differentiating between neoplastic and nonneoplastic lesions were 100%, 93.8%, and 97.9%, respectively, and these values were higher than those for conventional US (90.3%, 62.5%, and 80.9%, respectively). CEUS can sensitively reflect the microvascular perfusion in testicular lesions and offers high accuracy for characterizing them. [ABSTRACT FROM AUTHOR]

Published
2022
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32. Ultrasound contrast-enhanced imaging and in vitro antitumor effect of paclitaxel-poly(lactic-co-glycolic acid)-monomethoxypoly (ethylene glycol) nanocapsules with ultrasound-targeted microbubble destruction

Author

MA, JING, primary, XING, LING XI, additional, SHEN, MING, additional, LI, FAN, additional, ZHU, MING JIE, additional, JIN, LI FANG, additional, LI, ZHAOJUN, additional, GAO, FENG, additional, SU, YIJIN, additional, DUAN, YOU RONG, additional, and DU, LIAN FANG, additional

Published
2014
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47. Ultrasound targeted microbubble destruction-mediated gene delivery system: application to therapy for ocular disease

Author

Du, Jing, Du, Lian Fang, Li, Feng Hua, Zheng, Xiao Zhi, Li, Hong Li, Shi, Qiu Sheng, and Wu, Ying

Abstract

Background: Ocular disorders have greatest potential for benefit from gene therapy. The major obstacle in the clinical application of gene therapy is not due to the lack of an ideal gene, but rather the lack of a clinically safe and efficient gene transfer method. Ultrasound (US) targeted microbubble destruction (UTMD)-mediated gene delivery system as a noninvasive gene transfer method is now widely used in gene therapy of cardiovascular disease, muscular tissue, and tumor, and proved to effectively enhance gene transfer in various studies in vitro and in vivo. However, it is just the beginning of application for ophthalmological disease.

Published
2011
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48. Response to the Letter to the Editor by Chang et al.: Shear Wave Sonoelastography for Elasticity Measurement of the Levator Ani Muscle: An Alternative Posterior Approach.

Author

Tang, Jin‐hua and Du, Lian‐fang

Subjects
SHEAR waves, ELASTICITY, PELVIC floor, PUDENDAL nerve, ULTRASONIC imaging
Abstract

Levator ani muscle avison is one of the independent risk factors for symptoms and signs of prolapse.3 We believe that the elasticity of the levator ani muscle measured through the perineum can better reflect the elasticity of the levator ani muscle in women with pelvic floor dysfunction. Keywords: pelvic floor; ultrasound; shear wave elastography; levator ani muscle EN pelvic floor ultrasound shear wave elastography levator ani muscle 1051 1051 1 04/19/21 20210501 NES 210501 I Dear Editor i : We thank Chang et al. for their interest in our paper1 and for giving us the opportunity to discuss the approach about shear wave sonoelastography for elasticity measurement of the levator ani muscle. [Extracted from the article]

Published
2021
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49. Identification of carotid artery dissection by contrast enhanced ultrasonograph. A case report.

Author

Li, Zhao-jun, Luo, Xiang-hong, and Du, Lian-fang

Subjects
*CAROTID artery, *DIFFERENTIAL diagnosis, *DIAGNOSTIC imaging, *PHOSPHOLIPIDS, *SULFUR compounds, *ULTRASONIC imaging, *CONTRAST media, *CAROTID artery dissections
Abstract

Carotid arterial dissection is an important cause of stroke in young and middle-aged patients. Ultrasound (and particularly contrast enhanced ultrasonography) is an important approach in patients with sudden onset of stroke combined with renal failure who are not suitable for angiography. In this report we describe the ultrasound features of carotid arterial dissection and discuss its utility. [ABSTRACT FROM AUTHOR]

Published
2015
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50. Contrast-Enhanced Ultrasound for differential diagnosis of pancreatic mass lesions: a meta-analysis.

Author

Li Zhou Lin, Fan Li, Yang Liu, Ling Xi Xing, Lian Fang Du, Lin, Li Zhou, Li, Fan, Liu, Yang, Xing, Ling Xi, and Du, Lian Fang

Subjects
*CONTRAST-enhanced ultrasound, *DIAGNOSTIC ultrasonic imaging, *PANCREATIC diseases, *PANCREATIC cancer diagnosis, *DIFFERENTIAL diagnosis, *DIAGNOSIS, *COMPARATIVE studies, *DIAGNOSTIC imaging, *RESEARCH methodology, *MEDICAL cooperation, *META-analysis, *PANCREAS, *PANCREATIC tumors, *RESEARCH, *ULTRASONIC imaging, *SYSTEMATIC reviews, *EVALUATION research, *CONTRAST media, *DUCTAL carcinoma, RESEARCH evaluation
Abstract

Aim: To evaluate the diagnostic accuracy of contrast-enhanced ultrasound (CEUS) as a method for diagnosing pancreatic lesions with regard to the ductal pancreatic carcinoma and the differentiation of neoplastic from non-neoplastic lesions.Material and Methods: Relevant studies published by September 6, 2015 were retrieved from PubMed, Embase, and Cochrane Central Trials databases. The articles included were mainly based on the following criteria: use of CEUS as the diagnostic tool, and the use of histology as the reference method. Two independent reviewers inspected all these papers to confirm the matching of the inclusion criteria. One reviewer with methodological expertise extracted the data from the included studies. Sensitivity, specificity and diagnostic odds ratio (DOR) were used to obtain overall estimates.Results: Eighteen studies out of 734 articles initially identified met the inclusion criteria. The primary study objective with respect to ductal adenocarcinoma was verified in 15 studies. The pooled estimate of CEUS sensitivity for the differential diagnosis of duct adenocarcinomas was 0.90 (95 % CI, 0.89-0.92), and the specificity was 0.88 (0.84-0.90). The pooled estimate for DOR was 56.38 (29.91-106.33). The area under the curve under the summary receiver operating characteristic (SROC) was 0.95. 12 out of 18 studies examined CEUS sensitivity and the average specificity with regard to the secondary study objective, distinguishing between neoplastic lesions and non-neoplastic lesions, were 0.95 (0.94-0.96) and 0.83 (0.77-0.87). The pooled estimate for DOR was 73.25 (45.31-118.43). The area under the SROC curve was 0.96.Conclusions: CEUS is a promising, reliable modality for the differential diagnosis of pancreatic adenocarcinoma in patients with pancreatic mass lesions. The presence of a hypoenhanced lesion was a sensitive predictor of pancreatic adenocarcinomas. It seems to be a useful tool in clinical practice. [ABSTRACT FROM AUTHOR]

Published
2016
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