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12. Additional file 1 of Phthalide derivative CD21 attenuates tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke by enhancing macrophage scavenger receptor 1-mediated DAMP (peroxiredoxin 1) clearance

Author

Liu, Dong-Ling, Hong, Zhi, Li, Jing-Ying, Yang, Yu-Xin, Chen, Chu, and Du, Jun-Rong

Abstract

Additional file 1: Supplemental Figure S1. Chemical structure of Butylphthalide (A), Ligustilide (B) and CD21 (C). The molecular weight of both natural phthalides (Butylphthalide and Ligustilide) is 190, and the molecular weight of synthesized phthalide derivative CD21 is 262. Supplemental Figure S2. CD21 purity determination by Ultra high-performance liquid chromatography (UHPLC) analysis. Chromatographic separation was performed on Waters ACQUITY system and BEH C18 column (50 × 2.1 mm, 1.7 μm). The mobile phase was a mixture of acetonitrile and 0.1% phosphoric acid (30:70, v/v). The flow rate was 0.4 mL/min, and the column temperature was 35 °C. The detection wavelength was set at 225 nm. Supplemental Figure S3. Body weight loss of mice in the different groups. The data are expressed as mean ± SD, and analyzed by two way ANOVA with Bonferroni-Holm test (n = 10/group). #p < 0.05, ##p < 0.01, vs. tMCAO group 3 days after stroke; **p < 0.01, vs. tPA group 3 days after stroke; $$p < 0.01, vs. each group before stroke.

Published
2021
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21. Ligustilide reduces phenylephrine induced-aortic tension in vitro but has no effect on systolic pressure in spontaneously hypertensive rats

Author

Du, Jun-Rong, Yu, Yan, Yao, Yao, Bai, Bo, Zong, Xu, Lei, Yang, Wang, Cheng-Yuan, and Qian, Zhong-Ming

Subjects
Rats -- Research, Rats -- Physiological aspects, Rattus -- Research, Rattus -- Physiological aspects, Dong quai -- Usage, Dong quai -- Research, Dong quai -- Health aspects, Cardiovascular diseases -- Research, Cardiovascular diseases -- Care and treatment, Health
Published
2007

34. Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-kB Signaling.

Author

Zhou, Hong-Jing, Li, Hui, Shi, Meng-Qi, Mao, Xiao-Na, Liu, Dong-Ling, Chang, Yi-Ran, Gan, Yu-Miao, Kuang, Xi, and Du, Jun-Rong

Subjects
BRAIN injuries, CEREBRAL ischemia treatment
Abstract

Aging is the greatest independent risk factor for the occurrence of stroke and poor outcomes, at least partially through progressive increases in oxidative stress and inflammation with advanced age. Klotho is an antiaging gene, the expression of which declines with age. Klotho may protect against neuronal oxidative damage that is induced by glutamate. The present study investigated the effects of Klotho overexpression and knockdown by an intracerebroventricular injection of a lentiviral vector that encoded murine Klotho (LV-KL) or rat Klotho short-hairpin RNA (LV-KL shRNA) on cerebral ischemia injury and the underlying anti-neuroinflammatory mechanism. The overexpression of Klotho induced by LV-KL significantly improved neurobehavioral deficits and increased the number of live neurons in the hippocampal CA1 and caudate putamen subregions 72 h after cerebral hypoperfusion that was induced by transient bilateral common carotid artery occlusion (2VO) in mice. The overexpression of Klotho significantly decreased the immunoreactivity of glial fibrillary acidic protein and ionized calcium binding adaptor molecule-1, the expression of retinoic-acid-inducible gene-I, the nuclear translocation of nuclear factor-κB, and the production of proinflammatory cytokines (tumor necrosis factor α and interleukin-6) in 2VO mice. The knockdown of Klotho mediated by LV-KL shRNA in the brain exacerbated neurological dysfunction and cerebral infarct after 22 h of reperfusion following 2 h middle cerebral artery occlusion in rats. These findings suggest that Klotho itself or enhancers of Klotho may compensate for its aging-related decline, thus providing a promising therapeutic approach for acute ischemic stroke during advanced age. [ABSTRACT FROM AUTHOR]

Published
2018
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