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605 results on '"Drug Screening Assays"'

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1. The Kavaratamides: Discovery of Linear Lipodepsipeptides from the Marine Cyanobacterium Moorena bouillonii Using a Comparative Chemogeographic Analysis

2. 类器官技术在乳腺癌研究中的现状及应用.

3. Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer

4. 2-Arylquinolines as novel anticancer agents with dual EGFR/FAK kinase inhibitory activity: synthesis, biological evaluation, and molecular modelling insights

5. New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

6. 类器官在儿童遗传性疾病中的应用研究进展.

7. Tumor Genomic Profiling and Ex Vivo Drug Sensitivity Testing for Pediatric Leukemia and Lymphoma Patients.

8. Toward developing a metastatic breast cancer treatment strategy that incorporates history of response to previous treatments

9. A first-in-class anticancer dual HDAC2/FAK inhibitors bearing hydroxamates/benzamides capped by pyridinyl-1,2,4-triazoles

10. Innovative C 2 -symmetric testosterone and androstenedione dimers: Design, synthesis, biological evaluation on prostate cancer cell lines and binding study to recombinant CYP3A4

11. Sensitivity of Oncogenic KRAS-Expressing Cells to CDK9 Inhibition

12. Photosensitive Ru(II) Complexes as Inhibitors of the Major Human Drug Metabolizing Enzyme CYP3A4.

13. Scalable Total Synthesis, IP3R Inhibitory Activity of Desmethylxestospongin B, and Effect on Mitochondrial Function and Cancer Cell Survival

14. Discovery of antiproliferative and anti-FAK inhibitory activity of 1,2,4-triazole derivatives containing acetamido carboxylic acid skeleton

15. Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

16. A High-Content Screen Identifies Drugs That Restrict Tumor Cell Extravasation across the Endothelial Barrier

17. Exploring the Potential of Drug Response Assays for Precision Medicine in Ovarian Cancer

18. Predicting Drug Response and Synergy Using a Deep Learning Model of Human Cancer Cells

19. Dual targeting of GSK3B and HDACs reduces tumor growth and improves survival in an ovarian cancer mouse model

20. In vivo modeling of metastatic human high-grade serous ovarian cancer in mice.

21. Multimodel preclinical platform predicts clinical response of melanoma to immunotherapy.

22. Tutuilamides A–C: Vinyl-Chloride-Containing Cyclodepsipeptides from Marine Cyanobacteria with Potent Elastase Inhibitory Properties

23. Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98

24. DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma

25. Stress Resistance Screen in a Human Primary Cell Line Identifies Small Molecules That Affect Aging Pathways and Extend Caenorhabditis elegans' Lifespan.

26. The identification of candidate effective combination regimens for pancreatic cancer using the histoculture drug response assay

27. Deep Tumor Penetration of Drug-Loaded Nanoparticles by Click Reaction-Assisted Immune Cell Targeting Strategy

28. Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

29. A Syngeneic ErbB2 Mammary Cancer Model for Preclinical Immunotherapy Trials

30. A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers.

31. Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer

32. Exploration of the carmaphycins as payloads in antibody drug conjugate anticancer agents

33. A Circulating Tumor Cell-RNA Assay for Assessment of Androgen Receptor Signaling Inhibitor Sensitivity in Metastatic Castration-Resistant Prostate Cancer

34. Self‐Assembled Aptamer‐Grafted Hyperbranched Polymer Nanocarrier for Targeted and Photoresponsive Drug Delivery

35. Tumor-on-a-chip platform to investigate progression and drug sensitivity in cell lines and patient-derived organoids.

36. A Plug-and-Play, Drug-on-Pillar Platform for Combination Drug Screening Implemented by Microfluidic Adaptive Printing

37. In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways.

38. A Preclinical Assessment of 89Zr-atezolizumab Identifies a Requirement for Carrier Added Formulations Not Observed with 89Zr-C4

39. Splicing modulation sensitizes chronic lymphocytic leukemia cells to venetoclax by remodeling mitochondrial apoptotic dependencies

40. The Ashitaba (Angelica keiskei) chalcones 4-hydroxyderricin and xanthoangelol suppress melanomagenesis by targeting BRAF and PI3-K

41. Applications of tumor chip technology

42. Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer.

43. Kinome rewiring reveals AURKA limits PI3K-pathway inhibitor efficacy in breast cancer

44. Prevention of prostate cancer by natural product MDM2 inhibitor GS25: in vitro and in vivo activities and molecular mechanisms

45. Characterization of Rhamnolipids Produced by an Arctic Marine Bacterium from the Pseudomonas fluorescence Group.

46. Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer

47. Samholides, Swinholide-Related Metabolites from a Marine Cyanobacterium cf. Phormidium sp.

48. Photoactivated in Vitro Anticancer Activity of Rhenium(I) Tricarbonyl Complexes Bearing Water-Soluble Phosphines

49. Identification of Active Compounds against Melanoma Growth by Virtual Screening for Non-Classical Human DHFR Inhibitors.

50. Molecular diversity of phenothiazines: design and synthesis of phenothiazine–dithiocarbamate hybrids as potential cell cycle blockers

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