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6. Design cas témoins apparié sur score de risque : un outil méthodologique original pour une étude de l'efficacité vaccinale et des conséquences médicales de l'hospitalisation pour COVID-19 en France.

Author

Semenzato, L., primary, Botton, J., additional, Baricault, B., additional, Bouillon, K., additional, Vu, S. Le, additional, Jabagi, M-J., additional, Drouin, J., additional, Dray-Spira, R., additional, Weill, A., additional, and Zureik, M., additional

Published
2023
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24. Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC3437

Author

Da, C., primary, Zhang, D., additional, Stashko, M.A., additional, Cheng, A., additional, Hunter, D., additional, Norris-Drouin, J., additional, Graves, L., additional, Machius, M., additional, Miley, M.J., additional, DeRyckere, D., additional, Earp, H.S., additional, Graham, D.K., additional, Frye, S.V., additional, Wang, X., additional, and Kireev, D., additional

Published
2019
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33. Sequence of Mammalian Mitochondrial DNA

Author

Barrell, B. G., Anderson, S., Bankier, A. T., De Bruijn, M. H. L., Chen, E., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B., Sanger, F., Schreier, P. H., Smith, A. J. H., Staden, R., Young, I. G., Bücher, Th., editor, Sebald, W., editor, and Weiss, H., editor

Published
1980
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34. Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2541

Author

McIver, A.L., primary, Zhang, W., additional, Liu, Q., additional, Jiang, X., additional, Stashko, M.A., additional, Nichols, J., additional, Miley, M.J., additional, Norris-Drouin, J., additional, Machius, M., additional, DeRyckere, D., additional, Wood, E., additional, Graham, D.K., additional, Earp, H.S., additional, Kireev, D., additional, Frye, S.V., additional, and Wang, X., additional

Published
2017
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35. Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC2434

Author

Wang, X., primary, Liu, J., additional, Zhang, W., additional, Stashko, M.A., additional, Nichols, J., additional, DeRyckere, D., additional, Miley, M.J., additional, Norris-Drouin, J., additional, Chen, Z., additional, Machius, M., additional, Wood, E., additional, Graham, D.K., additional, Earp, H.S., additional, Graham, K., additional, Kireev, D., additional, and Frye, S.V., additional

Published
2017
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39. The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling

Author

Budry, L., Balsalobre, A., Gauthier, Y., Khetchoumian, K., L'Honore, A., Vallette-Kasic, S., Brue, T, Figarella-Branger, D., Meij, B.P., Drouin, J., Tissue Repair, Geneeskunde van gezelschapsdieren, Interactions cellulaires neuroendocriniennes (ICN), Université de la Méditerranée - Aix-Marseille 2-Centre National de la Recherche Scientifique (CNRS), Canadian Institutes of Health Research, Tissue Repair, and Geneeskunde van gezelschapsdieren

Subjects
Pituitary gland, Cellular differentiation, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, Biology, Chromatin remodeling, Mice, 03 medical and health sciences, Dogs, 0302 clinical medicine, Genetics, medicine, Animals, Humans, Pituitary ACTH Hypersecretion, Enhancer, Transcription factor, 030304 developmental biology, progenitors, 0303 health sciences, PAX7 Transcription Factor, Cell Differentiation, POMC, Tpit, differentiation, Chromatin Assembly and Disassembly, musculoskeletal system, Chromatin, Cell biology, medicine.anatomical_structure, Pituitary Gland, Homeobox, cell cycle, Cushing's disease, Corticotropic cell, tissues, 030217 neurology & neurosurgery, Research Paper, Developmental Biology
Abstract

Genes Dev. 2012 Oct 15;26(20):2299-310. doi: 10.1101/gad.200436.112. The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Budry L, Balsalobre A, Gauthier Y, Khetchoumian K, L'honoré A, Vallette S, Brue T, Figarella-Branger D, Meij B, Drouin J. Source Laboratoire de Génétique Moléculaire, Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Quebec H2W 1R7, Canada; Abstract The anterior and intermediate lobes of the pituitary gland derive from the surface ectoderm. They provide a simple system to assess mechanisms of developmental identity established by tissue determinants. Each lobe contains a lineage expressing the hormone precursor pro-opiomelanocortin (POMC): the corticotropes and melanotropes. The T-box transcription factor Tpit controls terminal differentiation of both lineages. We now report on the unique role of Pax7 as a selector of intermediate lobe and melanotrope identity. Inactivation of the Pax7 gene results in loss of melanotrope gene expression and derepression of corticotrope genes. Pax7 acts by remodeling chromatin and allowing Tpit binding to a new subset of enhancers for activation of melanotrope-specific genes. Thus, the selector function of Pax7 is exerted through pioneer transcription factor activity. Genome-wide, the Pax7 pioneer activity is preferentially associated with composite binding sites that include paired and homeodomain motifs. Pax7 expression is conserved in human and dog melanotropes and defines two subtypes of pituitary adenomas causing Cushing's disease. In summary, expression of Pax7 provides a unique tissue identity to the pituitary intermediate lobe that alters Tpit-driven differentiation through pioneer and classical transcription factor activities. PMID: 23070814 [PubMed - in process] PMCID: PMC3475802 [Available on 2013/4/15]

Published
2012

41. Transient dwarfismo and hypogonadism in mice lacking Otx1 reveal prepubescent stage-specific control and pituitary levels of GH, FSH and LH

Author

ACAMPORA A, MARZAN S, TUORTO F, AVVANTAGGIATO V, TREMBLAY JJ, LAZZARO D, DI CARLO A, MARIANO A, MACCHIA, PAOLO EMIDIO, CORTE G, DROUIN J. BRULET P, SIMEONE A., MACCHIA, VINCENZO, Acampora, A, Marzan, S, Tuorto, F, Avvantaggiato, V, Tremblay, Jj, Lazzaro, D, DI CARLO, A, Mariano, A, Macchia, PAOLO EMIDIO, Corte, G, Macchia, Vincenzo, DROUIN J., BRULET P, and Simeone, A.

Published
1998

44. LIST OF CONTRIBUTORS AND DISCUSSANTS

Author

Aurbach, G.D., primary, Bartter, F.C., additional, Beaulieu, M., additional, Beck, J.C., additional, Behrman, H.R., additional, Bernstein, R.S., additional, Billard, R.B., additional, Bogdanove, E.M., additional, Bolman, R.M., additional, Bradlow, H.L., additional, Brandt, E.J., additional, Bullock, L., additional, Burger, A.G., additional, Cahnmann, H.J., additional, Callard, I.P., additional, Campbell, G.T., additional, Canalis, E.M., additional, Carlson, D.E., additional, Caron, M.G., additional, Carriere, B., additional, Chamley, W.A., additional, Chapman, V., additional, Cheng, S., additional, Chopra, I.J., additional, Chopra, U., additional, Cody, V., additional, Cohen, S.L., additional, Cooper, C.W., additional, Danforth, E., additional, Davey, R., additional, De Léan, A., additional, Demers, L.M., additional, Dietrich, J.W., additional, Drouin, J., additional, Dupré, J., additional, Eastman, C.J., additional, Edelhoch, H., additional, Ellis, S., additional, Feigelson, M., additional, Ferland, L., additional, Fisher, D.A., additional, Frieden, E.H., additional, Friesen, H., additional, Frisch, R.E., additional, Furth, J., additional, Galton, V.A., additional, Gann, D.S., additional, Ganschow, R., additional, Gershengorn, M.C., additional, Glinoer, D., additional, Goldsmith, L., additional, Gorden, P., additional, Greenwood, F.C., additional, Greep, R.O., additional, Grindeland, R.E., additional, Gworek, S.C., additional, Hazelwood, R.L., additional, Hedge, G.A., additional, Heersche, J.N.M., additional, Hochman, J., additional, Hollander, V.P., additional, Ivey, J.L., additional, Kelly, P.A., additional, Kem, D.C., additional, Kennedy, T.G., additional, Kenny, A.D., additional, Knobil, E., additional, Kourides, I.A., additional, Labarca, C., additional, Labrie, F., additional, Lagacé, L., additional, LeCompte, P.M., additional, Leppaluoto, J.P., additional, Lequin, R.M., additional, Levy, R.P., additional, Lewis, U., additional, Linehan, W.A., additional, McDonald, J.K., additional, McKenzie, J.M., additional, McMurtry, J.P., additional, MacIntyre, I., additional, Martin, C.R., additional, Metzger, B.E., additional, Miller, M., additional, Morris, M., additional, Murray, F.T., additional, Nakamura, Y., additional, Nolin, J.M., additional, Novak, E., additional, O'Byrne, E., additional, Oppenheimer, J.H., additional, Orci, L., additional, Orr, J.C., additional, Osathanondh, R., additional, Paigen, K., additional, Papkoff, H., additional, Parsons, J.A., additional, Perrelet, A., additional, Pont, A., additional, Raisz, L.G., additional, Rall, J.E., additional, Ramaley, J.A., additional, Raymond, V., additional, Rice, B.F., additional, Robbins, J., additional, Robertson, G.L., additional, Ruf, K., additional, Samaan, N.A., additional, Samuelsson, B., additional, Schwabe, C., additional, Schwartz, N., additional, Segaloff, A., additional, Sims, E.A.H., additional, Solmon, D.H., additional, Sorimachi, K., additional, Spaulding, S., additional, Steinetz, B.G., additional, Sterling, K., additional, Sundberg, D.K., additional, Swank, R.T., additional, Swerdloff, R.S., additional, Talmage, R.V., additional, Tashjian, A.H., additional, Taurog, A., additional, Vaitukaitis, J.L., additional, van der Gugten, A.A., additional, van Middlesworth, L., additional, Vodian, M.A., additional, Ward, D.G., additional, Watson, G., additional, Weiss, G., additional, Wells, S.A., additional, White, A., additional, Wright, D.R., additional, Wu, S.Y., additional, and Yoshinaga, K., additional

Published
1978
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45. LIST OF CONTRIBUTORS AND DISCUSSANTS

Author

Anderson, R.N., primary, Aurbach, G.D., additional, Baird, A., additional, Balsan, S., additional, Bancroft, F.C., additional, Barofsky, A.L., additional, Barraclough, C.A., additional, Beattie, C.W., additional, Bellvé, A.R., additional, Billiar, R.B., additional, Bittman, E.L., additional, Bloch, B., additional, Böhlen, P., additional, Bradlow, H.L., additional, Brazeau, P., additional, Budzik, G.P., additional, Callard, G., additional, Callard, I., additional, Chambon, P., additional, Chatterton, R., additional, Clark, M.R., additional, Cohen, S.L., additional, Collins, D.C., additional, Concannon, P.W., additional, Cutler, G.B., additional, Czech, M.P., additional, DeGrange, D.A., additional, Dias, J.A., additional, Dierich, A., additional, Djiane, J., additional, Donahoe, P.K., additional, Drouin, J., additional, Dusanter-Fourt, I., additional, Earnest, D.J., additional, Eil, C., additional, Esch, F., additional, Feig, L., additional, Ferin, M., additional, Ferland, L.H., additional, Fiddes, J.C., additional, Foster, D.L., additional, French, F.S., additional, Friesen, H., additional, Frisch, R.E., additional, Gamblin, G.T., additional, Gaub, M-P., additional, Geller, J., additional, Gibori, G., additional, Goodman, R.L., additional, Grandison, L.J., additional, Greep, R.O., additional, Guillemin, R., additional, Gurr, J.A., additional, Hager, G.L., additional, Houdebine, L.-M., additional, Huseby, R.A., additional, Irvine, C., additional, Jakowlev, S., additional, Jongstra, J., additional, Kaibuchi, K., additional, Karsch, F.J., additional, Katoh, M., additional, Keefe, D.R., additional, Kelly, P.A., additional, Kessel, M., additional, Kikkawa, U., additional, Kishimoto, A., additional, Kourides, I.A., additional, Krust, A., additional, Labrie, F., additional, LePennec, J.-P., additional, Legan, S.J., additional, Liberman, U.A., additional, Lichtler, A.C., additional, Ling, N., additional, Littlefield, B.A., additional, MacDonald, G.J., additional, Marut, E.L., additional, Marx, S.J., additional, Means, A.R., additional, Merriam, G.R., additional, Moll, G., additional, Mougin, C., additional, Murphy, B., additional, Nekola, M.V., additional, Nicoll, C.S., additional, Nishizuka, Y., additional, Niswender, G.D., additional, Oppenheimer, J.H., additional, Osathanondh, R., additional, Ostrowski, M.C., additional, Oudet, P., additional, Papkoff, H., additional, Pastan, I., additional, Payne, A.H., additional, Pearson, O.H., additional, Peck, E.J., additional, Peter, R.E., additional, Pomerantz, D., additional, Posner, B., additional, Raj, M., additional, Rall, J.E., additional, Reudelhuber, T., additional, Richard-Foy, H., additional, Robertson, H., additional, Robinson, J.E., additional, Roser, J.F., additional, Russell, S.M., additional, Saffran, M., additional, Samaan, N., additional, Schulster, D., additional, Schwartz, N.B., additional, Segaloff, A., additional, Selmanoff, M.K., additional, Slaughter, G., additional, Sonnenschein, C., additional, Sterling, K., additional, Stone, R.T., additional, Swann, J., additional, Takai, Y., additional, Talmadge, K., additional, Teyssot, B., additional, Turek, F.W., additional, Van Vugt, D., additional, Walters, M.R., additional, Wardlaw, S., additional, Wehrenberg, W.B., additional, Weintraub, B., additional, Werder, K.V., additional, Wheeler, D., additional, Willingham, M.C., additional, Wise, P.M., additional, Wolf, O., additional, Wynn, P., additional, Ying, S.-Y., additional, Yoshinaga, Y., additional, Zeytin, F., additional, and Zor, U., additional

Published
1984
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47. Contributors

Author

ABOU-ISSA, HUSSEIN, primary, AURBACH, G.D., additional, BAHL, OM P., additional, BAXTER, JOHN D., additional, BEAULIEU, M., additional, BIRNBAUMER, L., additional, BOCKAERT, JOEL, additional, BOHNET, H.G., additional, BROWN, E.M., additional, CATT, K.J., additional, CHANNING, CORNELIA P., additional, CLARK, JAMES H., additional, DEDMAN, JOHN R., additional, DE LÉAN, A., additional, DILLMAN, W.H., additional, DROUIN, J., additional, DUFAU, M.L., additional, FAKUNDING, JOHN L., additional, FERLAND, L., additional, FRIESEN, H.G., additional, GARDNER, J.D., additional, GARLAND, BLYNN L., additional, GOODMAN, HOWARD M., additional, HUNZICKER-DUNN, MARY, additional, KAUMANN, A.J., additional, KEBABIAN, JOHN W., additional, LABRIE, F., additional, LAGRACE, L., additional, LATHAM, KEITH R., additional, LEDWITZ-RIGBY, FLORENCE, additional, LEE, EDDINGTON Y., additional, LEFKOWITZ, ROBERT J., additional, LINDSEY, ADA M., additional, MACLEOD, KATHRYN M., additional, MARTIAL, JOSEPH A., additional, MEANS, ANTHONY R., additional, MORIN, O., additional, MOYLE, WILLIAM R., additional, O'DEA, ROBERT F., additional, OPPENHEIMER, J.H., additional, PAPAVASILIOU, STATHIS S., additional, PECK, ERNEST J., additional, PERT, CANDACE B., additional, REICHERT, LEO E., additional, RICHARDS, Jo ANNE S., additional, RODBARD, DAVID, additional, SAMUELS, HERBERT H., additional, SEEBURG, PETER H., additional, SPIEGEL, A.M., additional, STRADA, SAMUEL J., additional, THANKI, KANTILAL, additional, JOSEPH THOMPSON, W., additional, TINDALL, DONALD J., additional, WALTON, KENNETH G., additional, WATERS, M.J., additional, WITTMANN, R., additional, and ZATZ, MARTIN, additional

Published
1978
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49. List of Contributors

Author

ABOU-ISSA, HUSSEIN, primary, AURBACH, G.D., additional, BAHL, OM P., additional, BAXTER, JOHN D., additional, BEAULIEU, M., additional, BIRNBAUMER, L., additional, BOCKAERT, JOEL, additional, BOHNET, H.G., additional, BROWN, E.M., additional, CATT, K.J., additional, CHANNING, CORNELIA P., additional, CLARK, JAMES H., additional, DEDMAN, JOHN R., additional, DE LÉAN, A., additional, DILLMANN, W.H., additional, DROUIN, J., additional, DUFAU, M.L., additional, FAKUNDING, JOHN L., additional, FERLAND, L., additional, FRIESEN, H.G., additional, GARDNER, J.D., additional, GARLAND, BLYNN L., additional, GOODMAN, HOWARD M., additional, HUNZICKER-DUNN, MARY, additional, KAUMANN, A.J., additional, KEBABIAN, JOHN W., additional, LABRIE, F., additional, LAGRACE, L., additional, LATHAM, KEITH R., additional, LEDWITZ-RIGBY, FLORENCE, additional, LEE, EDDINGTON Y., additional, LEFKOWITZ, ROBERT J., additional, LINDSEY, A.M., additional, MacLEOD, KATHRYN M., additional, MARTIAL, JOSEPH A., additional, MEANS, ANTHONY R., additional, MORIN, O., additional, MOYLE, WILLIAM R., additional, O'DEA, ROBERT F., additional, OPPENHEIMER, J.H., additional, PAPAVASILIOU, STATHIS S., additional, PECK, ERNEST J., additional, PERT, CANDACE B., additional, REICHERT, LEO E., additional, RICHARDS, JOANNE S., additional, RODBARD, DAVID, additional, SAMUELS, HERBERT H., additional, SEEBURG, PETER H., additional, SPIEGEL, A.M., additional, STRADA, SAMUEL J., additional, THANKI, KANTILAL, additional, JOSEPH THOMPSON, W., additional, TINDALL, DONALD J., additional, WALTON, KENNETH G., additional, WATERS, M.J., additional, WITTMAN, R., additional, and ZATZ, MARTIN, additional

Published
1978
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