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2. Optimal treatment strategy after first-line induction therapy in advanced HER2-positive oeso-gastric adenocarcinoma—a retrospective, international, multicentric AGEO study

Author

Bergen, Elisabeth S., Pilla, Lorenzo, Auclin, Edouard, Ilhan-Mutlu, Aysegül, Prager, Gerald W., Pietrantonio, Filippo, Antista, Maria, Ghelardi, Filippo, Basile, Debora, Aprile, Giuseppe, Longarini, Raffaella, Hautefeuille, Vincent, Tougeron, David, Artru, Pascal, Mabro, May, Drouillard, Antoine, Roth, Gael, Ben Abdelghani, Meher, Clement, Inès, Toullec, Clemence, Mineur, Laurent, Guimbaud, Rosine, Taieb, Julien, and Zaanan, Aziz

Published
2023
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7. Chemotherapy in advanced pancreatic adenosquamous carcinoma: A retrospective multicenter AGEO study

Author

Auvray Kuentz, Marie, primary, Hautefeuille, Vincent, additional, de Mestier, Louis, additional, Coutzac, Clélia, additional, Lecomte, Thierry, additional, Nardon, Victor, additional, Artru, Pascal, additional, Turpin, Anthony, additional, Drouillard, Antoine, additional, Malka, David, additional, Tran‐Minh, My‐Linh, additional, Trouilloud, Isabelle, additional, Lièvre, Astrid, additional, Williet, Nicolas, additional, Pernot, Simon, additional, Touchefeu, Yann, additional, Taieb, Julien, additional, Hammel, Pascal, additional, and Zaanan, Aziz, additional

Published
2023
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8. Performance of a blood-based RNA signature for gemcitabine-based treatment in metastatic pancreatic adenocarcinoma

Author

Piquemal, David, primary, Bruno, Roman, additional, Bournet, Barbara, additional, Ghiringhelli, Francois, additional, Noguier, Florian, additional, Canivet, Cindy, additional, Bertaut, Aurélie, additional, Pierrat, Fabien, additional, Evesque, Ludovic, additional, Gamez, Amelia, additional, Cros, Jerome, additional, Rederstorff, Emilie, additional, Petit, Erwan, additional, Adnet, Johan, additional, Saint, Angélique, additional, Drouillard, Antoine, additional, Kempf, Emmanuelle, additional, Soularue, Emilie, additional, Vincent, Julie, additional, Baumgaertner, Isabelle, additional, Hennequin, Audrey, additional, Tournigand, Christophe, additional, Trabada Ataz, Daniel Lopez, additional, Bengrine, Leila, additional, Lepage, Come, additional, Manfredi, Sylvain, additional, Afchain, Pauline, additional, Trouilloud, Isabelle, additional, Gagnaire, Alice, additional, LoConte, Noelle K., additional, and Bachet, Jean-Baptiste, additional

Published
2023
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13. Associations between the severity of medical and surgical complications and perception of surgeon empathy in esophageal and gastric cancer patients

Author

Gehenne, Lucie, Lelorain, Sophie, Eveno, Clarisse, Piessen, Guillaume, Mariette, Christophe, Glehen, Olivier, d'Journo, Xavier, Mathonnet, Muriel, Regenet, Nicolas, Meunier, Bernard, Baudry, Anne-Sophie, Christophe, Véronique, Adenis, Antoine, Aparicio, Thomas, Assenat, Eric, Barret, Maximilien, Benhaim, Leonor, Benoit, Céline, Bergeat, Damien, Boige, Valérie, Borie, Fréderic, Bouche, Olivier, Bourriez, Damien, Brichon, Pierre-Yves, Brigand, Cécile, Carrere, Nicolas, Cattan, Pierre, Christou, Niki, Coffin, Benoit, Cohen, Romain, Collet, Denis, Conroy, Thierry, Dahan, Laetitia, Deguelte, Sophie, Di Fiore, Fréderic, Dousset, Bertrand, Drouillard, Antoine, Dumont, Frédéric, Elhajbi, Farid, Fabre, Jean Michel, Fabre, Joseph, Gagniere, Johan, Galais, Marie Pierre, Germain, Adeline, Geyl, Sophie, Goere, Diane, Gornet, Jean Marc, Granger, Victoire, Gronnier, Caroline, Guimbaud, Rosine, Hautefeuille, Vincent, Helyon, Morgane, Jougon, Jacques, Lebreton, Gilles, Lefevre, Jérémie, Lepage, Côme, Lievre, Astrid, Marchal, Frédéric, Mathieu, Pierre, Mathysiak, Tamara, Michot, Nicolas, Moszkowicz, David, Moussata, Driffa, Msika, Simon, Neuzillet, Cindy, Ouaissi, Medhi, Paquette, Brice, Paye, François, Penna, Christophe, Père, Guillaume, Perrier, Marine, Peschaud, Frédérique, Pezet, Denis, Phoutthsang, Valérie, Pocard, Marc, Rat, Paul, Regimbeau, Jean Marc, Renaud, Florence, Sabate, Jean-Marc, Souche, Régis, Terrebonne, Eric, Tessier, Williams, Thomas, Pascal Alexandre, Turpin, Anthony, Vaudoyer, Delphine, Vienot, Angélique, Voron, Thibault, You, Benoit, Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 (SCALab), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Lyon Sud [CHU - HCL] (CHLS), Hospices Civils de Lyon (HCL), Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Chirurgie digestive, endocrinienne et générale [CHU Limoges], CHU Limoges, Centre hospitalier universitaire de Nantes (CHU Nantes), CHU Pontchaillou [Rennes], Centre hospitalier [Valenciennes, Nord], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Génétique Moléculaire de Montpellier (IGMM), and Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
medicine.medical_specialty, Esophageal Neoplasms, media_common.quotation_subject, education, [SDV.CAN]Life Sciences [q-bio]/Cancer, Empathy, MESH: Perception, Odds, Postoperative complications, MESH: Surgeons, 03 medical and health sciences, 0302 clinical medicine, Stomach Neoplasms, Perception, Internal medicine, Humans, Medicine, 030212 general & internal medicine, Major complication, Retrospective Studies, Cancer, media_common, Multinomial logistic regression, Surgeons, Physician-Patient Relations, MESH: Humans, business.industry, Nursing research, MESH: Retrospective Studies, Cognition, MESH: Stomach Neoplasms, medicine.disease, Patient-physician communication, MESH: Empathy, Oncology, 030220 oncology & carcinogenesis, MESH: Esophageal Neoplasms, MESH: Physician-Patient Relations, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Objective: To assess the impact of global physician empathy and its three subdimensions (establishing rapport, emotional and cognitive processes) on the severity of postoperative complications in a sample of cancer patients.Methods: We retrospectively analyzed data on 256 patients with esogastric cancer from the French national FREGAT database. Empathy and its subdimensions were assessed using the patient-reported CARE scale and the severity of medical and surgical complications was reported with the Clavien-Dindo classification system. The usual covariates were included in multinomial logistic regression analyses.Results: Physician empathy predicted the odds of reporting major complications. When patients perceived high empathy, they were less likely to report major complications compared to no complications (OR = .95, 95% CI = [.91-.99], p = .029). Among the three dimensions, only "establishing rapport" (OR = .84, 95% CI = [.73-.98], p = .019) and the "emotional process" (OR = .85, 95% CI = [.74-.98], p = .022) predicted major complications.Conclusions: Physician empathy is essential before surgery. Further research is needed to understand the mechanisms associating empathy with health outcomes in cancer. Physicians should be trained to establish good rapport with patients, especially in the preoperative period.

Published
2021

18. La qualité de la mangue (Mangifera indica) : une étude du continuum pré et post-récolte par analyse expérimentale et modélisation

Author

Drouillard, Antoine, STAR, ABES, and Agricultural Sciences for sustainable Development - - AGRO2010 - ANR-10-LABX-0001 - LABX - VALID

Subjects
Fruit quality, [SDV.SA] Life Sciences [q-bio]/Agricultural sciences, Modélisation, Plant physiology, Modeling, Mangifera indica, Qualité du fruit, Physiologie végétale
Abstract

This thesis is part of a project initiated at CIRAD in 2000 (Lechaudel et al. 2004, Nodey et al. 2014) for the improvement of the quality of Cogshall mangoes produced in Réunion. The main objective of this study was to analyse the effect of agronomic practices and storage conditions on mango's quality considering the continuum between pre- and post-harvest. Then using those analysis to identify possible levers of controls to improve the quality of Cogshall mango. Three complementary approaches were used in this work. The first approach was an experimental study focused on the evolution of fruit quality according to agronomic practices (leaves to fruit ratio), harvest dates and storage conditions (temperature and storage duration). Quality was assessed using indicators of maturity (respiration and ethylene emissions), physical quality (fresh weight, dry weight, colour, etc.) and gustatory quality (sugar concentrations, acidity, etc.). The results showed the importance of the source-sink relationship between the fruit and the branch on the fruit’s growth. In addition, the quality of the fruit at harvest largely determines the quality of the fruit in storage at maturity. The harvest induces the maturation of harvested fruits. Storage practices are then used to control and optimize this harvest-induced ripening. Low temperatures used during storage can extend the storage duration and ensure an acceptable concentration of sugars even before the climacteric crisis. The second approach was designed to study the variations of sugars in fruits through a model. This model was calibrated using available data (Lechaudel et al., 2005b; Joas et al., 2009) and the data collected for the experimental approach. This 'sugar model' simulates the variations of the 4 main sugars (starch, sucrose, fructose, and glucose) during the growth and the maturation on-tree and stored fruits. This approach suggested a strong significance, in pre-harvest, of starch and sucrose synthesis metabolisms. While in post-harvest, the fluxes representing the sucrose synthesis, starch degradation and the transformation of glucose molecules into fructose molecules are the most significant ones. The third approach used a "virtual mango" model to identify potentially beneficial agronomic and storage practices to improve fruit quality. All models developed for the sugar model were added to existing growth models (Lechaudel et al., 2005a, 2007). This coupled model was then adapted to include the fruit’s weight loss during the storage phase. The 'virtual mango' model was used to simulate changes of quality (fresh weight, dry matter content and sweetness) according to multiple possible combinations of cultural practices and storage conditions. These simulations are in accordance with the observed significance of agronomical practices during the growth and harvest date on the quality of fully matured fruit. Non-limiting conditions (sufficient irrigation and light exposure with reasonable fruit load) would result in the best possible fruit quality. Harvest dates and storage practices would then be selected according to conditions during growth and selected markets. On the one hand, later harvests are more suitable for local markets with good quality fruit and a shelf life of a few days. On the other hand, earlier harvests allow for longer storage durations (export, longer time to market, etc.) at the cost of a slight decrease in fruit quality at maturity. Even though the "virtual mango" model can only predict variations in fresh weight, dry matter content and sugar concentrations throughout the growth and ripening of mangoes. All the analysis and models produced in this work are relevant tools for studying and monitoring the development of mango quality throughout the pre- and post-harvest continuum., Ce travail de thèse s’inscrit dans le cadre d’un projet initié au CIRAD en 2000 (Léchaudel, 2004;Nordey, 2014) visant l’amélioration de la qualité des mangues Cogshall à la Réunion. L’objectif central dela thèse est l’analyse des facteurs sources de variation de la qualité de la mangue tout au long du continuumentre le pré et le post-récolte afin d’identifier des leviers de contrôle disponibles pour améliorer la qualité desmangue Cogshall. Trois approches complémentaires ont été réalisées.La première approche a été une étude expérimentale permettant de suivre la qualité des fruits en fonc-tion de pratiques agronomiques (rapport feuilles/fruits), des dates de récolte et des conditions de conserva-tion (température et temps de conservation). La qualité a été évaluée en utilisant des indicateurs de maturité(respiration et concentration en éthylène), de qualité physique (poids frais, poids sec, couleur, etc.) et dequalité gustative (concentrations des sucres, acidité, etc.). Cette étude a montré l’importance de la relationsource-puits entre le fruit et le rameau sur la croissance du fruit. De plus, la qualité du fruit à la récolte vadéterminer en grande partie la qualité potentielle des fruits en conservation. La récolte force le fruit à mûrir etles pratiques de conservation permettent de contrôler et optimiser cette maturation induite. Les températuresbasses vont permettre de prolonger le temps de conservation des fruits et d’assurer une concentration maxi-male en sucres avant d’atteindre la pleine maturité. Cette pratique va ainsi permettre d’assurer une qualitérelativement bonne et homogène sur les fruits conservés.La deuxième approche a été construite autour de l’étude des variations des sucres dans les fruits autravers d’un modèle. Ce modèle a été calibré en utilisant des données existantes (Léchaudel et al., 2005a;Joas et al., 2009) et les données de l’approche expérimentale. Ce modèle sucres simule les variations des4 sucres majeurs (amidon, sucrose, fructose et glucose) durant la croissance et la maturation sur l’arbreet en chambre froide. Cette approche a suggéré une forte importance, en pré-récolte, des métabolismes desynthèse de l’amidon et du saccharose. Alors que les flux les plus important en post-récolte ont été la synthèsedu saccharose, la dégradation de l’amidon en sucres solubles ainsi que le flux représentant l’action de laphosphoglucose isomérase permettant de transformer des molécules de glucose en molécules de fructose.Le modèle sucres a ensuite été implanté dans les modèles de croissances de Léchaudel et al. (2005b,2007) pour permettre de modéliser la croissance du fruit ainsi que les variations de sucres et des flux decarbone dans le fruit. Puis ce modèle a été simplifié et adapté pour pouvoir simuler la perte en masse desfruits lors de leurs conservation. Ce modèle couplé a été appelé « mangue virtuelle » et utilisé pour simulerde multiples scénarios possibles d’opération culturales et de conditions de conservation. Ces simulations ontété réalisées pour tester virtuellement des milliers de combinaisons de pratiques et leurs effets sur le poidsfrais du fruit, le taux de matière sèche et la sucrosité. Ces simulations ont à nouveau montré l’importance desconditions de croissance et de la date de la récolte sur la qualité des fruits à pleine maturité. Les résultats ontsuggéré que des conditions non-limitantes avec une bonne irrigation, un bon ensoleillement et une chargeen fruit raisonnée permet l’obtention de meilleurs fruits. Les dates de récolte ainsi que les pratiques deconservation seront elles décidées en fonction des conditions de croissance et des marchés souhaités. Lesrécoltes tardives conviendront le mieux pour une vente sur un marché local avec des fruits de très bonnequalité et au temps de conservation de quelques jours. Alors que des récoltes à la fin de la croissance du fruitcorrespondent plus à des pratiques de conservation de longues durées (export, allongement de la mise sur lemarché, etc.) avec une légère diminution de la qualité des fruits à maturité.L’ensemble des analyses et des modèles produits dans ce travail représentent des outils efficaces per-mettant de mieux comprendre et piloter l’élaboration de la qualité des mangues sur tout le continuum pré etpost-récolte. Cependant, des améliorations ont été identifiées pour donner la capacité au modèle de s’adapterà de nouvelles conditions environnementales.

Published
2021

19. Nutrition entérale en cancérologie digestive

Author

Mouillot, Thomas, Brindisi, Marie-Claude, Drouillard, Antoine, Marref, Imène, Brondel, Laurent, Lepage, Côme, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Centre des Sciences du Goût et de l'Alimentation [Dijon] (CSGA), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Université Bourgogne Franche-Comté [COMUE] (UBFC), and Fédération Francophone de Cancérologie Digestive (FFCD)

Subjects
gastrostomy, enteral nutrition, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, malnutrition, digestive cancer, nasogastric tube
Abstract

International audience; Protein-energy malnutrition, is estimated between 35 and 67% depending on digestive tumor locations, significantly worsens the morbidity and mortality. Nutritional status should be assessed regularly during hospitalization and at each visit. If the diagnosis of undernutrition is retained according to HAS criteria, adapted and personalized nutritional support is essential for an optimal oncological management. The nutritional prescription is often approximate. The evaluation of ingesta, by a dietician or a visual analogical scale, is a necessary prerequisite. Thus, in case of moderate undernutrition with a low intake or in case of severe undernutrition with a functional digestive tract, enteral nutrition appears as the optimal support. This enteral nutrition can be administered through a nasogastric tube, gastrostomy or even jejunostomy depending on the duration of nutrition, the need for upper gastrointestinal surgery or gastroparesis. Nutritional intake, with a standard solution as first line, must be done with caution if the patient is at risk of refeeding syndrome until a target of 30 to 35 kcal/kg/d is reached with 1.2 to 1.5 g/kg/d of protein. Nutrition should be re-evaluated regularly and continued until the nutritional goals set with the patient are achieved.

Published
2020

20. Risk factors for Coronavirus Disease 2019 (COVID-19) severity and mortality among solid cancer patients and impact of the disease on anticancer treatment: A French nationwide cohort study (GCO-002 CACOVID-19)

Author

Lièvre, Astrid, primary, Turpin, Anthony, additional, Ray-Coquard, Isabelle, additional, Le Malicot, Karine, additional, Thariat, Juliette, additional, Ahle, Guido, additional, Neuzillet, Cindy, additional, Paoletti, Xavier, additional, Bouché, Olivier, additional, Aldabbagh, Kais, additional, Michel, Pierre, additional, Debieuvre, Didier, additional, Canellas, Anthony, additional, Wislez, Marie, additional, Laurent, Lucie, additional, Mabro, May, additional, Colle, Raphael, additional, Hardy-Bessard, Anne-Claire, additional, Mansi, Laura, additional, Colomba, Emeline, additional, Bourhis, Jean, additional, Gorphe, Philippe, additional, Pointreau, Yoann, additional, Idbaih, Ahmed, additional, Ursu, Renata, additional, Di Stefano, Anna Luisa, additional, Zalcman, Gérard, additional, Aparicio, Thomas, additional, Moulin, Solenne, additional, Leleu, Olivier, additional, Leparree, Sylvie, additional, Goasdoue, Henri, additional, Piprot, Christine, additional, Tourneur, Gerald, additional, Bayart, Vincent, additional, Lignier, Delphine, additional, Lachaier, Emma, additional, Khamari, Marwa, additional, Coutte, Alexandre, additional, Siembida, Nicolas, additional, Houessinon, Aline, additional, Regimbeau, Jean Marc, additional, Chauffert, Bruno, additional, Moreira, Aurélie, additional, Hautefeuille, Vincent, additional, Hee, Christine, additional, Boone, Mathieu, additional, Bihan, Céline, additional, Chive, Emilie, additional, Poulet-Potriquier, Stéphane, additional, Fahem, Rachida, additional, Luet, Dominique, additional, Roquin, Guillaume, additional, Vitellius, Carole, additional, Cornet-Trichereau, Nathanaëlle, additional, Caroli-Bosc, François-Xavier, additional, Thirot-Bidault, Anne, additional, Ropert, Stanislas, additional, Gachet - Masson, Julie, additional, Dehais, Mélanie, additional, L'helgoualc'h, Gwen-Ael, additional, Ali-Mahamadou, Ibrahim, additional, Talfi, Safia, additional, Belmont, Laure, additional, Kilendo, Dieudonné, additional, Benrezzak, Nasro, additional, Dubief, Emeline, additional, Conroy, Guillaume, additional, Delique, Laurence, additional, Basso, Maud, additional, Pons, Isabelle, additional, Salignon, Karine, additional, Villing, Anne-Laure, additional, Mougenot, Emmanuelle, additional, Porebski, Cassandra, additional, Guiatni, Asma, additional, Cloarec, Nicolas, additional, Mineur, Laurent, additional, Bouchaud, Marie, additional, David, Céleste, additional, Peytier, Annie, additional, Greletty, Thomas, additional, Audemar, Franck, additional, Vignes, Emanuelle, additional, Minne, Floriane, additional, Goldzak, Guillaume, additional, Huysman, Fabienne, additional, Hocine, Fayçal, additional, Lakkis, Zaher, additional, Meynard, Guillaume, additional, Almotlak, Hamadi, additional, Klajer, Elodie, additional, Sun, Xu-Shan, additional, Wasselin, Julie, additional, Catala, Pascale, additional, Mazuy, Claire, additional, Vandamme, Hélène, additional, Prevost, Jean-Briac, additional, Fadin, Aurélie, additional, Basson, Laurent, additional, Huguet, Jean-Baptiste, additional, Dos Santos, Emmanuelle, additional, Jany, Bérangère, additional, Saad, Alain, additional, Goutorbe, Frédéric, additional, Oziol, Eric, additional, Ramdani, Mohamed, additional, Kadiri, Ouafae, additional, Garbay, Delphine, additional, Huet, Clotilde, additional, Giroux Leprieur, Etienne, additional, Teng, Wen, additional, Monvoisin, Justine, additional, Arnaud Coffin, Patrick, additional, Roux, Sylvie, additional, Orfeuvre, Hubert, additional, Chagros, Mélanie, additional, Pillon, Didier, additional, Rassoul, Agathe, additional, Poureau, Pierre Guillaume, additional, Novello, Cécile, additional, Ducray, François, additional, Trouba, Cécile, additional, Bastit, Vianney, additional, Babin, Emmanuel, additional, Leon, Vincent, additional, Courtecuisse, Anne-Catherine, additional, Vambre, Julie, additional, Tack, Vincent, additional, Desauw, Christophe, additional, Meniai, Fatima, additional, Peres, Christina, additional, Esparcieux, Aurélie, additional, Perrier, Hervé, additional, Doux, Nathalie, additional, Kaphan, Régis, additional, Roques, Bertrand, additional, Rebischung, Christine, additional, Mille, Dominique, additional, Fernandes, Gaëlle, additional, Abdelli, Naceur, additional, Jousset, Natacha, additional, Combe, Pierre, additional, Jonveaux, Eric, additional, Dumont, Patrick, additional, Kanaan, Marc, additional, Berthelot Gras, Corinne, additional, Panis, Valérie, additional, Kaluzinski, Laure, additional, Venant-Valery, Marjolène, additional, Lam, You-Heng, additional, Vallee, Laura, additional, Riviere, Frédéric, additional, Durand, Muriel, additional, Benghadid, Dihya, additional, Villeneuve, Emilie, additional, Hentic Dhome, Olivia, additional, Bounouar, Zedjiga, additional, De Mestier, Louis, additional, Dubois, Jacqueline, additional, Eyriey, Magali, additional, Moreau, Lionel, additional, Baihas, Dib, additional, Aldabbagh, Kaïs, additional, Degriffolet, Dominique, additional, Sebbagh, Virginie, additional, Seghezzi, Jean-Christophe, additional, Lozach-Brugirard, Marion, additional, Mandrou, Julie, additional, Mavier, Loubna, additional, Hennetier, Florence, additional, Wagner, Jean-Philippe, additional, Carola, Elisabeth, additional, Chandirakumaran, Karthiga, additional, Loutski, Sandrine, additional, Cojean-Zelek, Isabelle, additional, Bouras, Amina, additional, Lacour, Sandrine, additional, Froura, Fahem, additional, Ben Nadji, Hadjer, additional, Cattelain, Sophie, additional, Darloy, Franck, additional, Jolimoy Boilleau, Geneviève, additional, Maissiat, Cyrielle, additional, Darut-Jouve, Ariane, additional, Lorgis, Véronique, additional, Charifi-Alaoui, Ikram, additional, Ghiringhelli, François, additional, Drouillard, Antoine, additional, Chaix, Marie, additional, Manfredi, Sylvain, additional, Lepage, Côme, additional, Gagnaire, Alice, additional, Latournerie, Marianne, additional, jourdan, Sofia, additional, Perrot, Nora, additional, folia, Mireille, additional, Minello, Anne, additional, Jouve, Jean-Louis, additional, Fery, Marielle, additional, Landau, Alain, additional, Evrard, Diane, additional, Valenza, Bruno, additional, Paitel, Jean-François, additional, Chablais, Laetitia, additional, Kreitmann, Thomas, additional, Lancry-Lecomte, Laurence, additional, Monard, Adrien, additional, Faugeras, Eve, additional, Boucheret, Paul, additional, Glommeau, Cécile, additional, Tchikladze, Christine, additional, Garnier Tixidre, Claire, additional, Long, Jérôme, additional, Zaidi, Manel, additional, Delabarre, Véronique, additional, Meyzenc, Juliette, additional, Ferrand, Loïc, additional, Moro-Sibilot, Denis, additional, Bouheret, Paul, additional, Leyronnas, Cécile, additional, Herve, Camille, additional, Thoor, Audrey, additional, Jacquet, Emanuelle, additional, Roth, Gaël, additional, Madapathage-Senanyake, Videsheka, additional, Chupeau, Peggy, additional, Bieber, Elsa, additional, Rosso, Maud, additional, Lepage, Isabelle, additional, Priou, Frank, additional, Laly, Margot, additional, Aprelon, Sylvie, additional, Sobolak, Natacha, additional, Homokos, Helen, additional, Watelle, Fabienne, additional, Pham-Becker, Alice, additional, Lauridant, Géraldine, additional, Dujardin, Charlotte, additional, Lenglin, Etienne, additional, Nienguet Tsota, Aimée, additional, Dominguez, Sophie, additional, Forestier, Alexandra, additional, Nouvel, Franck, additional, Lerooy, Justine, additional, Ratajczak, Céline, additional, Romano, Olivier, additional, Brzyski, Dorothéee, additional, Barriere, Aurélien, additional, Genet, Dominique, additional, Tisse, Julien, additional, Zasadny, Xavier, additional, Grelet, Adeline, additional, Hennion-Imbault, Amélie, additional, Haustraete, Eglantine, additional, Louafi, Samy, additional, Awad, Manal, additional, Zekri, Younes, additional, Cheneau, Caroline, additional, Leissen, Nolwen, additional, Egreteau, Joëlle, additional, Breant, Alexandra, additional, Sarabi, Matthieu, additional, Labonne, Stéphanie, additional, Forestier, Julien, additional, Leclercq, Céline, additional, Prunier-Bossion, Florence, additional, Ray Coquard, Isabelle, additional, Guillet, Marielle, additional, Theillaumas, Aurélie, additional, Prome, Emilie, additional, Walter, Thomas, additional, Philouze, Pierre, additional, Lawo, Melody, additional, De Talhouet, Solène, additional, Beuvelot, Johanne, additional, Molin, Yann, additional, Bellecoste Martin, Marie, additional, Saussereau, Maud, additional, Agnelli, Lauren, additional, Fakhry, Nicolas, additional, Laplace, Christophe, additional, Norguet Monnereau, Emmanuelle, additional, Boucard, Céline, additional, Djenad, Kahina, additional, Fontaine, Catherine, additional, Seitz, Jean-François, additional, Dahan, Laétitia, additional, Sigrand, Julie, additional, Duluc, Muriel, additional, Locher, Christophe, additional, Fleury, Marjory, additional, Brou Marie, Ange, additional, Berkane, Ramdane, additional, Poupblanc, Séverine, additional, Auby, Dominique, additional, Petran, Daniela, additional, Texereau, Patrick, additional, Guerineau, Elodie, additional, Andre, Morgan, additional, Mahjoubi, Linda, additional, Sarrazin, Fanny, additional, Jeanson, Sonia, additional, Gschwend, Anthony, additional, Birr, Virginie, additional, Fore, Mathieu, additional, Noirclerc, Monique, additional, Dahou, Sihem, additional, Spaeth, Dominique, additional, Lambotin, Mélanie, additional, Lelu, Thomas, additional, Linot, Benjamin, additional, Hugon, Nathalie, additional, Rousseau, Dominique, additional, Castanie, Hélène, additional, Lenne, Carole, additional, Lortholary, Alain, additional, Cessot, Anatole, additional, Merzoug, Messaouda, additional, Naudin, Cécile, additional, Vannetzel, Jean-Michel, additional, Aziz, Ghina, additional, Hadj Arab, Yacine, additional, Pernes, Stéphanie, additional, Roche-Lachaise, Isabelle, additional, Fiteni, Frédéric, additional, Yahiaoui, Hadjer, additional, Marel Lopez, Gwendoline, additional, Oddoz, Jeanne, additional, Peira, Fabienne, additional, Michel, Olivier, additional, Meunier, Jérôme, additional, Ouahrani, Brahim, additional, Roger, Antoine, additional, Branco, Sonia, additional, Nguyen, Van, additional, Gisselbrecht, Mathilde, additional, Hammad, Ghania, additional, Mordant, Pierre, additional, Stroksztejn, Magda, additional, Pocard, Marc, additional, Nlo Meyengue, Luc, additional, Sacco, Emmanuelle, additional, Simon Anne, Sophie, additional, Fabre-Guillevin, Elizabeth, additional, Slim, Marine, additional, Zaanan, Aziz, additional, Cadranel, Jacques, additional, Pluvy, Johan, additional, Ursu, Rénata, additional, Geraldo, Amyrath, additional, Lihi, Rime, additional, Vo, Maryline, additional, Brouk, Zohra, additional, Colle, Raphaël, additional, Bennamoun, Mostefa, additional, Lacan, Fabrice, additional, Louvet, Christophe, additional, Mebarki, Soraya, additional, Veyri, Marianne, additional, Paillaud, Elena, additional, Lucas, Christelle, additional, Dubreuil, Olivier, additional, Lyamani, Jamila, additional, Agguini, Hanane, additional, Soularue, Emilie, additional, Jourdaine, Clément, additional, Verillaud, Benjamin, additional, Herzine, Hakima, additional, Raymond, Eric, additional, Mathiot, Nathalie, additional, Palmieri, Lola Jade, additional, Epanya, Christian, additional, Taieb, Julien, additional, Bertrand, Eliane, additional, Goujon, Gaël, additional, Namour, Céline, additional, Gazeau, Benoit, additional, Zafirova, Biljana, additional, Mirghani, Haitham, additional, Belin, Catherine, additional, Belkhir, Kahina, additional, Gharib, Myriam, additional, Vozy, Aurore, additional, Amrane, Karim, additional, Spano, Jean-Philippe, additional, Wassermann, Johanna, additional, Feuvret, Loic, additional, Bachet, Jean-Baptiste, additional, Philonenko, Sara, additional, Guillot, Laetitia, additional, Zabbe, Marion, additional, Gibiat, Stéphanie, additional, Baylot, Camille, additional, Jouinot, Aude, additional, Leduc, Nicolas, additional, Vieillot, Sabine, additional, James, Laurie, additional, Ducerf, Camille, additional, Blanc, Jean-Frédéric, additional, Falandry Leger, Claire, additional, Wautot, Virginie, additional, Chauvenet, Marion, additional, Vincent, Aude, additional, Tougeron, David, additional, Goulvent, Sandrine, additional, Suc, Etienne, additional, Laurenty, Anne-Pascale, additional, Marquis, Eric, additional, Bonnaire, Margaux, additional, Dewolf, Maxime, additional, Brenet, Esteban, additional, Billard, Delphine, additional, Litre, Claude-Fabien, additional, Dumazet, Antoine, additional, Botsen, Damien, additional, Vazel, Marion, additional, Carlier, Claire, additional, Bonnerave, David, additional, Marchand-Crety, Charles, additional, Bouche, Olivier, additional, Fosse, Patricia, additional, Sefrioui, David, additional, Watson, Sarah, additional, Torche, Fatah, additional, Muron, Thierry, additional, Natur, Stéphane, additional, Desgrippes, Romain, additional, Bihel, Véronique, additional, Ferrand, François-Régis, additional, Leiterer, Caroline, additional, Lavole, Julie, additional, Moquet, Claire, additional, Pressoir, Nathalie, additional, Dziukala, Catherine, additional, Ligeza Poisson, Catherine, additional, Naji, Abdelhalim, additional, Williet, Nicolas, additional, Phelip, Jean-Marc, additional, Di Palma, Fabrice, additional, Kherrour Mehdi, Amina, additional, Langrand-Escure, Julien, additional, Fournel, Pierre, additional, Pigne, Grégoire, additional, Saban-Roche, Léa, additional, Magne, Nicolas, additional, Vassal, Cécile, additional, Jacquin, Jean-Philippe, additional, Ramirez, Carole, additional, Vallard, Alexis, additional, Collard, Olivier, additional, Rivoirard, Romain, additional, Graber, Ivan, additional, Trager Maury, Stéphanie, additional, Duboisset, Elodie, additional, Ayllon Ugarte, Jorge, additional, Rami, Dalilia, additional, Saler, Christine, additional, Reinbolt, Manon, additional, Le Fevre, Clara, additional, Ben Abdelghani, Meher, additional, Dourthe, Louis-Marie, additional, Perruisseau-Carrier, Joffrey, additional, Nguimpi-Tambou, Marlène, additional, Barret, Flavie, additional, Di Stefano Anna, Luisa, additional, Balthazard, Annie, additional, Vassord-Dang, Camille, additional, Le Marchand, Mathilde, additional, Vergniol, Julien, additional, Pripon, Iulia, additional, Daemaegdt, Axelle, additional, Latry, Vanessa, additional, Larrieu, Muna, additional, Landry, Gaëlle, additional, Touihri Maximin, Laetitia, additional, Del Piano, Francesco, additional, Barlet, Agnès, additional, Vernisse, Mylène, additional, Lafond, Sophie, additional, Genin, Charline, additional, Sibertin-Blanc, Camille, additional, Chabrillac, Emilien, additional, Gregoire, Caroline, additional, Vergez, Sébastien, additional, Panouille, Quentin, additional, Guimbaud, Rosine, additional, Richa, Floriane, additional, Lebellec, Loïc, additional, Gounin, Sophie, additional, Buiret, Guillaume, additional, Baudin, Marine, additional, Hamon, Hervé, additional, Deshorgue, Anne-Claire, additional, Barrascout, Eduardo, additional, Legrand, Stéphanie, additional, Houlze, Morgane, additional, Cambula, Linda, additional, Lopez, Anthony, additional, Fouquet, Guillaume, additional, Touabi, Kahina, additional, GermaIn, Adeline, additional, Godbert, Benoit, additional, Voivret, Florence, additional, Perrin, Julie, additional, Da Silva, Rosa, additional, and Bernichon, Emilie, additional

Published
2020
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22. Épidémiologie du cancer du pancréas

Author

Drouillard , Antoine, Manfredi , Sylvain, Lepage , Come, Bouvier , Anne-Marie, Registre Bourguignon des Cancers Digestifs, Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ) -Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ) -Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Lipides - Nutrition - Cancer [Dijon - U1231] ( LNC ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Service d'hépato-gastroentérologie et cancérologie digestive (CHU de Dijon), and Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon )

Subjects
Épidémiologie, Survival, Epidemiology, Survie, Incidence, Cancer du pancréas, Pancreatic cancer, [ SDV.CAN ] Life Sciences [q-bio]/Cancer
Abstract

IF 0.853; International audience; Actually, pancreatic cancer is a major challenge in digestive oncology. Its prognosis remains very poor with a five-year net survival less than 10%. Although if pancreatic cancer incidence was low, data from French digestive cancer registries show a dramatic increase in recent years, more marked in women (annual variation of +3.6% between 1982 and 2012) than in men (+2.3%). The currently recognized risk factors like tobacco or obesity cannot explain this evolving epidemiology. Moreover, progress in understanding pancreatic carcinogenesis is still insufficient. Except for familial aggregation, systematic screening couldn’t be proposed.; Le cancer du pancréas représente aujourd’hui un challenge important en oncologie digestive. Son pronostic est très sombre avec une survie nette à 5 ans inférieure à 10 % tous stades confondus. Même si son incidence reste faible, les données issues des registres des cancers digestifs français montrent une augmentation au cours des dernières années. Cette incidence croissante, plus marquée chez les femmes (variation annuelle de +3,6 % entre 1982 et 2012) que chez les hommes (+2,3 %), reste aujourd’hui mal expliquée. Les facteurs de risque actuellement reconnus que sont le tabac et l’obésité ne permettent pas à eux seuls d’expliquer cette évolution épidémiologique. Par ailleurs, les progrès dans la connaissance de la carcinogenèse pancréatique restent encore insuffisants. En dehors des formes familiales pour lesquelles des recommandations de surveillance commencent à émerger, il n’y a pas de place pour le dépistage des personnes asymptomatiques.

Published
2018

23. Trends in incidence of small bowel cancer according to histology: a population-based study.

Author

Bouvier, Anne-Marie, Robaszkiewicz, Michel, Jooste, Valérie, Cariou, Mélanie, Drouillard, Antoine, Bouvier, Véronique, Nousbaum, Jean-Baptiste, The French Network of Cancer Registries (FRANCIM), Amadeo, Brice, Arveux, Patrick, Baldi, Isabelle, Bara, Simona, Clavel, Jacqueline, Colonna, Marc, Coureau, Gaëlle, Cowppli-Bony, Anne, Dabakuyo, Sandrine, Dalmeida, Tania, Daubisse-Marliac, Laetitia, and Defossez, Gautier

Subjects
NEUROENDOCRINE tumors, HISTOLOGY, CANCER, SARCOMA, AGE groups, EPIDEMIOLOGY of cancer, ADENOCARCINOMA, DUODENAL tumors, JEJUNUM tumors, ILEUM diseases, DISEASE incidence, ACQUISITION of data, SEX distribution, LYMPHOMAS
Abstract

Background: Small bowel cancer is not a single entity. Population-based studies taking into account histological diversity are scarce. The aim of this study was to report on their trends in incidence by histology in France over the past 20 years.Methods: All patients with a small bowel cancer diagnosed in 15 French administrative areas covered by a registry from the network of French cancer registries (FRANCIM) were included. Age-standardized incidence rates were estimated using the world standard population. Incidence rates were calculated by gender, age group, histology, and 5-year period.Results: The overall age-standardized incidence rates were 1.46/100,000 inhabitants in men and 0.9/100,000 inhabitants in women. Adenocarcinoma was the most common histological type (38%), followed by neuroendocrine tumors (35%), lymphoma (15%) and sarcoma (12%). Age at diagnosis and tumor location differed between adenocarcinoma and neuroendocrine tumors. The incidence of all four tumor types increased significantly over the 20-year period, with the exception of lymphoma in men. The annual percentage change for neuroendocrine tumors was 3.89% in men and 3.61% in women; for sarcoma, it was 3.38% and 4.08%, respectively. The incidence of adenocarcinoma and lymphoma also increased in women with an annual percentage change of 3.05% and 3.32%, respectively.Conclusion: Small bowel cancer incidence has increased over time. This increase occurred with different amplitudes and patterns in the four major histological types. The improvement in imaging techniques could partly explain this increase. It is necessary to determine whether predisposing conditions may contribute to this change. [ABSTRACT FROM AUTHOR]

Published
2020
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26. DLL4 expression is a prognostic marker and may predict gemcitabine benefit in resected pancreatic cancer

Author

Drouillard, Antoine, Puleo, Francesco, Bachet, Jean-Baptiste, Ouazzani, Sohaib, Calomme, Annabelle, Demetter, Pieter, Verset, Gontran, Van Laethem, Jean-Luc, Marechal, Raphaël, Drouillard, Antoine, Puleo, Francesco, Bachet, Jean-Baptiste, Ouazzani, Sohaib, Calomme, Annabelle, Demetter, Pieter, Verset, Gontran, Van Laethem, Jean-Luc, and Marechal, Raphaël

Abstract

Background:There is an increasing interest for Notch signalling pathway and particularly Delta-like ligand 4 (DLL4) as potential therapeutic target to improve outcome for patients with pancreatic ductal adenocarcinoma (PDAC).Methods:Using immunohistochemistry (IHC) and tissue microarray (TMA), we assessed the expression patterns of DLL4, Notch1 and Notch3 in 151 patients from two independent cohorts of resected PDAC. We investigated the prognostic and the predictive significance of these proteins.Results:High IHC DLL4 expression in cancer cells was associated with worse overall survival (OS) and disease-free survival (DFS) than low DLL4 expression (median OS: 12.9 vs 30.4 months, P=0.004 and median DFS: 8.8 vs 17.4 months, P=0.02). High DLL4 expression remained a significant negative prognostic factor in multivariate analysis (HR for OS: 2.1, P=0.02 and HR for DFS: 2.0, P=0.02). Low DLL4 abundance was associated with a longer OS-only for patients who received an adjuvant gemcitabine-based chemotherapy (P<0.001) but not for patients who did not receive gemcitabine (P=0.72). Furthermore, the interaction test for adjuvant gemcitabine therapy was statistically significant (P<0.001). The validating cohort recapitulated the findings of the training cohort.Conclusions:Low DLL4 abundance in tumour cells may predict the benefit from adjuvant gemcitabine therapy after PDAC resection., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2016

27. How To Implement An Innovative Environmental Management Device In Kodagu?

Author

Aubert, Pierre-Marie, Vendé, Jeremy, Leroy, Maya, Drouillard, Antoine, Favrat, Aurélien, Guégan, Benoît, Laborie-Roussel, Sylvène, Loffler, Laura, Lopez, Ruben, Moreno-Cruz, Cecilia, Parizel, Alexandre, Roy, Pierre-François, Skandarski, Marina, Montpellier Research in Management (MRM), Université Montpellier 1 (UM1)-Université Paul-Valéry - Montpellier 3 (UPVM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Perpignan Via Domitia (UPVD)-Groupe Sup de Co Montpellier (GSCM) - Montpellier Business School-Université de Montpellier (UM), Centre Jacques Berque (CJB), Ministère de l'Europe et des Affaires étrangères (MEAE)-Centre National de la Recherche Scientifique (CNRS), AgroParisTech, Registre Bourguignon des Cancers Digestifs, Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Montpellier Research in Management ( MRM ), Université Montpellier 1 ( UM1 ) -Université Paul-Valéry - Montpellier 3 ( UM3 ) -Université Montpellier 2 - Sciences et Techniques ( UM2 ) -Université de Perpignan Via Domitia ( UPVD ) -Groupe Sup de Co Montpellier (GSCM) - Montpellier Business School-Université de Montpellier ( UM ), Centre Jacques Berque ( CJB ), Ministère de l'Europe et des Affaires étrangères ( MEAE ) -Centre National de la Recherche Scientifique ( CNRS ), Lipides - Nutrition - Cancer (U866) ( LNC ), Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ) -Université de Bourgogne ( UB ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon ( ENSBANA ) -Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand ( CHU Dijon ), Leroy, Maya, Université de Perpignan Via Domitia (UPVD)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université Paul-Valéry - Montpellier 3 (UPVM)-Groupe Sup de Co Montpellier (GSCM) - Montpellier Business School-Université Montpellier 1 (UM1), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), and Université Montpellier 1 (UM1)-Groupe Sup de Co Montpellier (GSCM) - Montpellier Business School-Université Paul-Valéry - Montpellier 3 (UPVM)-Université de Montpellier (UM)-Université Montpellier 2 - Sciences et Techniques (UM2)-Université de Perpignan Via Domitia (UPVD)

Subjects
[SHS.SOCIO]Humanities and Social Sciences/Sociology, [SHS.SOCIO] Humanities and Social Sciences/Sociology, [ SHS.SOCIO ] Humanities and Social Sciences/Sociology, [ SHS.ENVIR ] Humanities and Social Sciences/Environmental studies, [SDE.ES]Environmental Sciences/Environmental and Society, [SHS.SCIPO]Humanities and Social Sciences/Political science, [SHS.ENVIR] Humanities and Social Sciences/Environmental studies, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, [SHS.GESTION]Humanities and Social Sciences/Business administration, [SDE.ES] Environmental Sciences/Environmental and Society, [SHS.GESTION] Humanities and Social Sciences/Business administration, [ SHS.GESTION ] Humanities and Social Sciences/Business administration, [SHS.SCIPO] Humanities and Social Sciences/Political science, [ SHS.SCIPO ] Humanities and Social Sciences/Political science, [ SDE.ES ] Environmental Sciences/Environmental and Society
Abstract

no abstract

Published
2013

29. [Epidemiology of pancreatic cancer].

Author

Drouillard A, Manfredi S, Lepage C, and Bouvier AM

Subjects
Female, France epidemiology, Global Health statistics & numerical data, Humans, Incidence, Male, Obesity complications, Pancreatic Neoplasms etiology, Pancreatic Neoplasms mortality, Prognosis, Risk Factors, Sex Distribution, Sex Factors, Smoking adverse effects, Pancreatic Neoplasms epidemiology
Abstract

Actually, pancreatic cancer is a major challenge in digestive oncology. Its prognosis remains very poor with a five-year net survival less than 10%. Although if pancreatic cancer incidence was low, data from French digestive cancer registries show a dramatic increase in recent years, more marked in women (annual variation of +3.6% between 1982 and 2012) than in men (+2.3%). The currently recognized risk factors like tobacco or obesity cannot explain this evolving epidemiology. Moreover, progress in understanding pancreatic carcinogenesis is still insufficient. Except for familial aggregation, systematic screening couldn't be proposed., (Copyright © 2017 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)

Published
2018
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30. [Colorectal cancer surgery with curative intent: what surveillance?].

Author

Drouillard A and Lepage C

Subjects
Carcinoembryonic Antigen blood, Colonoscopy, Colorectal Neoplasms pathology, Continuity of Patient Care, Diagnostic Imaging, Humans, Neoplasm Recurrence, Local prevention & control, Colorectal Neoplasms surgery, Neoplasm Recurrence, Local diagnosis
Abstract

Colorectal cancer, incidence has increased by more than 50% over the past 30 years. On the other hand, over the same period, the number of deaths remained stable, which reflects major therapeutic progress. Around 75% of patients may benefit from surgical resection with curative intent. Among them, nearly 30% of stage II and more than 55% of stage III patients present a loco-regional or distant recurrence or a metachronous cancer within 5 years after initial treatment. This high risk of recurrence raises the question of postoperative monitoring in order to detect early recurrences and metachronous cancers at a curable stage. The annual incidence of adenomas is low and the cumulative risk of endoluminal recurrences or metachronous cancer is very low. Therefore intensive endoscopic monitoring is not useful. Postoperative monitoring of distant recurrences is poorly codified. However, despite their limits, recent trials and meta-analysis suggest that survival is increased thanks to clinical monitoring combined with hepatic and pulmonary imaging. CEA measurement usefulness remains debated. A large randomised trial of monitoring strategy ended recently and should provide answers. This report focused on the monitoring mode after curative resection.

Published
2015

31. Trends in incidence and management of cancer of the ampulla of Vater.

Author

Rostain F, Hamza S, Drouillard A, Faivre J, Bouvier AM, and Lepage C

Subjects
Adolescent, Adult, Age Distribution, Age Factors, Aged, Aged, 80 and over, Ampulla of Vater pathology, Biliary Tract Surgical Procedures adverse effects, Biliary Tract Surgical Procedures mortality, Chi-Square Distribution, Child, Child, Preschool, Common Bile Duct Neoplasms diagnosis, Common Bile Duct Neoplasms mortality, Female, France epidemiology, Humans, Incidence, Infant, Infant, Newborn, Male, Middle Aged, Multivariate Analysis, Neoplasm Staging, Pancreaticoduodenectomy adverse effects, Pancreaticoduodenectomy mortality, Proportional Hazards Models, Prospective Studies, Registries, Risk Factors, Sex Distribution, Sex Factors, Time Factors, Treatment Outcome, Young Adult, Ampulla of Vater surgery, Biliary Tract Surgical Procedures trends, Common Bile Duct Neoplasms epidemiology, Common Bile Duct Neoplasms therapy, Palliative Care trends, Pancreaticoduodenectomy trends
Abstract

Aim: To provide trends in incidence, management and survival of cancer of the ampulla of Vater in a well-defined French population., Methods: Data were obtained from the population-based digestive cancer registry of Burgundy over a 34-year period. Age-standardized incidence rates were computed using the world standard population. Average annual variations in incidence rates were estimated using a poisson regression. A univariate and multivariate relative survival analysis was performed., Results: Age-standardized incidence rates were 0.46 and 0.30 per 100000 inhabitants for men and women, respectively. Incidence rate increased from 0.26 (1976-1984) to 0.58 (2003-2009) for men and remained stable for women. Resection for cure was performed in 48.3% of cases. This proportion was stable over the study period. Among cases with curative resection, pancreatico-duodenectomy was performed in 94.0% of cases and ampullectomy in 6.0% of cases. A total of 50.8% of cancers of the ampulla of Vater were diagnosed at an advanced stage. Their proportion remained stable throughout the study period. The overall 1- and 5-year relative survival rates were 60.2% and 27.7%, respectively. Relative survival did not vary over time. Treatment and stage at diagnosis were the most important determinants of survival. The 5-year relative survival rate was 41.5% after resection for cure, 9.5% after palliative surgery and 6.7% after symptomatic treatment. In multivariate analysis, only stage at diagnosis significantly influenced the risk of death., Conclusion: Cancer of the ampulla of Vater is still uncommon, but its incidence increased for men in Burgundy. Diagnosis is often made at an advanced stage, dramatically worsening the prognosis.

Published
2014
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