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Your search keyword '"Droste-Borel, Irina"' showing total 13 results
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13 results on '"Droste-Borel, Irina"'

1. The Arabidopsis U1 snRNP regulates mRNA 3′-end processing

Author

Mangilet, Anchilie F., Weber, Joachim, Schüler, Sandra, Adler, Manon, Mjema, Eneza Yoeli, Heilmann, Paula, Herold, Angie, Renneberg, Monique, Nagel, Luise, Droste-Borel, Irina, Streicher, Samuel, Schmutzer, Thomas, Rot, Gregor, Macek, Boris, Schmidtke, Cornelius, and Laubinger, Sascha

Published
2024
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2. The tomato receptor CuRe1 senses a cell wall protein to identify Cuscuta as a pathogen

Author

Hegenauer, Volker, Slaby, Peter, Körner, Max, Bruckmüller, Julien-Alexander, Burggraf, Ronja, Albert, Isabell, Kaiser, Bettina, Löffelhardt, Birgit, Droste-Borel, Irina, Sklenar, Jan, Menke, Frank LH, Maček, Boris, Ranjan, Aashish, Sinha, Neelima, Nürnberger, Thorsten, Felix, Georg, Krause, Kirsten, Stahl, Mark, and Albert, Markus

Subjects
Agricultural, Veterinary and Food Sciences, Plant Biology, Biological Sciences, Vaccine Related, Infectious Diseases, Infection, Cell Wall, Cuscuta, Gene Expression Regulation, Plant, Host-Parasite Interactions, Solanum lycopersicum, Plant Diseases, Plant Proteins
Abstract

Parasitic plants of the genus Cuscuta penetrate shoots of host plants with haustoria and build a connection to the host vasculature to exhaust water, solutes and carbohydrates. Such infections usually stay unrecognized by the host and lead to harmful host plant damage. Here, we show a molecular mechanism of how plants can sense parasitic Cuscuta. We isolated an 11 kDa protein of the parasite cell wall and identified it as a glycine-rich protein (GRP). This GRP, as well as its minimal peptide epitope Crip21, serve as a pathogen-associated molecular pattern and specifically bind and activate a membrane-bound immune receptor of tomato, the Cuscuta Receptor 1 (CuRe1), leading to defense responses in resistant hosts. These findings provide the initial steps to understand the resistance mechanisms against parasitic plants and further offer great potential for protecting crops by engineering resistance against parasitic plants.

Published
2020

4. The ArabidopsisU1 snRNP regulates mRNA 3′-end processing

Author

Mangilet, Anchilie F., Weber, Joachim, Schüler, Sandra, Adler, Manon, Mjema, Eneza Yoeli, Heilmann, Paula, Herold, Angie, Renneberg, Monique, Nagel, Luise, Droste-Borel, Irina, Streicher, Samuel, Schmutzer, Thomas, Rot, Gregor, Macek, Boris, Schmidtke, Cornelius, and Laubinger, Sascha

Abstract

The removal of introns by the spliceosome is a key gene regulatory mechanism in eukaryotes, with the U1 snRNP subunit playing a crucial role in the early stages of splicing. Studies in metazoans show that the U1 snRNP also conducts splicing-independent functions, but the lack of genetic tools and knowledge about U1 snRNP-associated proteins have limited the study of such splicing-independent functions in plants. Here we describe an RNA-centric approach that identified more than 200 proteins associated with the ArabidopsisU1 snRNP and revealed a tight link to mRNA cleavage and polyadenylation factors. Interestingly, we found that the U1 snRNP protects mRNAs against premature cleavage and polyadenylation within introns—a mechanism known as telescripting in metazoans—while also influencing alternative polyadenylation site selection in 3′-UTRs. Overall, our work provides a comprehensive view of U1 snRNP interactors and reveals novel functions in regulating mRNA 3′-end processing in Arabidopsis, laying the groundwork for understanding non-canonical functions of plant U1 snRNPs.

Published
2024
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6. The Arabidopsis U1 snRNP regulates mRNA 3'-end processing

Author

Mangilet, Anchilie F., primary, Weber, Joachim, additional, Schueler, Sandra, additional, Droste-Borel, Irina, additional, Streicher, Samuel, additional, Schmutzer, Thomas, additional, Rot, Gregor, additional, Macek, Boris, additional, and Laubinger, Sascha, additional

Published
2023
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9. Arabidopsis RNA processing factor SERRATE regulates the transcription of intronless genes

Author

Speth, Corinna, primary, Szabo, Emese Xochitl, additional, Martinho, Claudia, additional, Collani, Silvio, additional, zur Oven-Krockhaus, Sven, additional, Richter, Sandra, additional, Droste-Borel, Irina, additional, Macek, Boris, additional, Stierhof, York-Dieter, additional, Schmid, Markus, additional, Liu, Chang, additional, and Laubinger, Sascha, additional

Published
2018
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10. Author response: Arabidopsis RNA processing factor SERRATE regulates the transcription of intronless genes

Author

Speth, Corinna, primary, Szabo, Emese Xochitl, additional, Martinho, Claudia, additional, Collani, Silvio, additional, zur Oven-Krockhaus, Sven, additional, Richter, Sandra, additional, Droste-Borel, Irina, additional, Macek, Boris, additional, Stierhof, York-Dieter, additional, Schmid, Markus, additional, Liu, Chang, additional, and Laubinger, Sascha, additional

Published
2018
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11. Arabidopsis RNA processing factor SERRATE regulates the transcription of intronless genes

Author

Speth, Corinna, Szabo, Emese Xochitl, Martinho, Claudia, Collani, Silvio, zur Oven-Krockhaus, Sven, Richter, Sandra, Droste-Borel, Irina, Macek, Boris, Stierhof, York-Dieter, Schmid, Markus, Liu, Chang, Laubinger, Sascha, Speth, Corinna, Szabo, Emese Xochitl, Martinho, Claudia, Collani, Silvio, zur Oven-Krockhaus, Sven, Richter, Sandra, Droste-Borel, Irina, Macek, Boris, Stierhof, York-Dieter, Schmid, Markus, Liu, Chang, and Laubinger, Sascha

Abstract

Intron splicing increases proteome complexity, promotes RNA stability, and enhances transcription. However, introns and the concomitant need for splicing extend the time required for gene expression and can cause an undesirable delay in the activation of genes. Here, we show that the plant microRNA processing factor SERRATE (SE) plays an unexpected and pivotal role in the regulation of intronless genes. Arabidopsis SE associated with more than 1000, mainly intronless, genes in a transcription-dependent manner. Chromatin-bound SE liaised with paused and elongating polymerase II complexes and promoted their association with intronless target genes. Our results indicate that stress-responsive genes contain no or few introns, which negatively affects their expression strength, but that some genes circumvent this limitation via a novel SE-dependent transcriptional activation mechanism. Transcriptome analysis of a Drosophila mutant defective in ARS2, the metazoan homologue of SE, suggests that SE/ARS2 function in regulating intronless genes might be conserved across kingdoms.

Published
2018
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