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3. Metabolic disorders and blood fatty acids status in hospitalized very old patients: part I of the Alpha-linolenage study⋆⋆⋆

Author

Henry Olivier, Combe Nicole, Vaysse Carole, Lopez Carlos, Driss Fathi, Fonseca Isabelle, Simon Noëmie, Le Guillou Céline, Masselin-Silvin Sylvie, David Jean-Philippe, and Mendy François

Subjects
Alpha-linolenage study, fatty acids, elderly, ALA, PUFA, rapeseed oil, Oils, fats, and waxes, TP670-699
Abstract

Background: previous studies showed that hospitalized elderly women had low Polyunsaturated fatty acids (PUFA) intake and concomitantly showed biochemical indices of essential fatty acid (EFA) insufficiency. Objectives: the Alpha-Linolenage study aimed to improve health parameters of hospitalized very elderly patients, aged 85 years. The objective of the Part I of the Alpha-linolenage study was to assess blood fatty acid status and parameters of metabolic disorders of these patients at the baseline. Design: from 2009 to 2011, 188 patients entering the geriatric department of Emile Roux Hospitals, Île-de-France region, France, were included. Data on the lipid status were obtained through analysis of fatty acid compositions of plasma cholesterol esters and erythrocyte phospholipids. Results: because of our inclusion criteria, there was a high prevalence of CV disease, affecting 74% of our participants. Patients ingested an average of 1586 kcal per day. Fat accounted for 49.2 g/d. Both LA and ALA intakes were not reached, i.e. on average 5 g/d of LA vs. 8–10 g and 1.2 g/d of ALA vs. 2–2.5 g recommended, respectively. The LA and ALA blood status reflected this situation; their contents were lower than those waited under sufficient EFA diet. Conclusion: in very elderly patients a status of chronic disease may generate CV or mortality risk factors. A low fat intake, with both insufficient LA and ALA intakes might favor the harmful role played by de novo lipogenesis, Indeed, a cornerstone of dietary guidelines, i.e. restriction of fat and saturated fat, may be related to risk of disease. The second part of the alpha-linolenage study will aim to improve markers of the metabolic disorders by providing sufficiently lipids.

Published
2015
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10. List of Contributors

Author

Abia, Rocio, primary, Aguila, Marcia Barbosa, additional, Alcaraz, Miguel, additional, Aldini, Giancarlo, additional, Alonso, Alvaro, additional, de Cienfuegos, Gerardo Álvarez, additional, Amaral, Joana S., additional, Amirante, Paolo, additional, Amores, Victoria, additional, Amoruso, Angela, additional, Andrade, Paula B., additional, Andreadou, I., additional, Angioni, Alberto, additional, Ankan, Aysun, additional, Antunes, Lusânia Maria Greggi, additional, Apetrei, C., additional, Aramendía, María A., additional, Arbones-Mainar, Jose Miguel, additional, Arias, José L., additional, Arienti, Giuseppe, additional, Armenta, Sergio, additional, Assy, Nimmer, additional, Audi, Nama’a, additional, Azadmard-Damirchi, Sodeif, additional, Azqueta, Amaia, additional, Badiu, Diana, additional, Ballabio, Davide, additional, Balesteros, Manoela Ruchiga, additional, Ballesteros, Evaristo, additional, Barbosa, Décio Sabbatini, additional, Barbouti, Alexandra, additional, Bardelli, Claudio, additional, Batanero, Eva, additional, Baumann, Leslie, additional, Benavente-García, Obdulio, additional, Becker, Peter, additional, Bendini, Alessandra, additional, Benedetti, Simona, additional, Beretta, Giangiacomo, additional, Bermudez, Beatriz, additional, Bes-Rastrollo, Maira, additional, Bianchi, Maria de Lourdes Pires, additional, Bisignano, Giuseppe, additional, Blanco, Santos, additional, Boskou, George, additional, Bracci, Tania, additional, Bravo, Laura, additional, Brenes, Manuel, additional, Brescia, Maria Antonietta, additional, Briasoulis, Evangelos, additional, Brunelleschi, Sandra, additional, Bucci, Remo, additional, Buckland, Genevieve, additional, Buratti, Susanna, additional, Buróníó, María I., additional, Busconi, Matteo, additional, Cabello-Moruno, Rosana, additional, Caboni, Pierluigi, additional, Cabras, Paolo, additional, Caggia, Cinzia, additional, Camuesco, Desiree, additional, Cancelas, Jesús, additional, Capasso, Giovambattista, additional, Capote, F. Priego, additional, Cárdenas, Soledad, additional, Carluccio, Maria Annunziata, additional, Carrasco-Pancorbo, Alegria, additional, Carnuccio, Rosa, additional, Carrera, María Pilar, additional, Carretero, Antonio Segura, additional, Casado, Francisco Javier, additional, Castillo, Julián, additional, Caturla, Nuria, additional, Cerretani, Lorenzo, additional, Chillemi, Rosa, additional, Chiou, Antonia, additional, Choi, Shin-Geon, additional, Christian, Mildred S., additional, Chondrogianni, Niki, additional, Churruca, Itziar, additional, Cirugeda, Miguel de la Guardia, additional, de Castro, Antonio, additional, De Caterina, Raffaele, additional, Cavaliere, Chiara, additional, Chinou, Ioanna, additional, Clodoveo, Maria Lisa, additional, Coimbra, Manuel A., additional, Conte, Lanfranco S., additional, Cosio, M. Stella, additional, Covas, Maria Isabel, additional, Coxam, Véronique, additional, Cunha, Sara C., additional, Curiel, Jose Antonio, additional, D’Angelo, Stefania, additional, Daniel, Hannelore, additional, Davicco, Marie-Jeanne, additional, De Bonis, Maria Luigia, additional, De Castro, M.D. Luque, additional, de la Higuera, Manuel, additional, de la Puerta, Cristina, additional, de las Rivas, Blanca, additional, de la Torre, Rafael, additional, Delcuratolo, Debora, additional, De Leonardis, Antonella, additional, De Lucia, Maria, additional, de Oliveira, Marcone Augusto Leal, additional, de Pablo, Manuel A., additional, De Roos, Baukje, additional, De Saja, Jose A., additional, De Stefano, Daniela, additional, Di Bella, Giuseppa, additional, Dichi, Isaias, additional, Diener, Robert M., additional, Dirsch, Verena M., additional, d’Ischia, Marco, additional, Driss, Fathi, additional, Dugo, Giacomo, additional, Dutta, Paresh C., additional, Ebizuk, Yutaka, additional, El-Benna, Jamel, additional, Esteban, Francisco J., additional, Estepa, Amparo, additional, da Silva, Joaquim C.G. Esteves, additional, Fabiani, Roberto, additional, Facino, Roberto Maffei, additional, Faria, M.A., additional, Faria, Miguel, additional, Fernandes, José O., additional, Fernandez-Gutierrez, Alberto, additional, Fernández-Montesinos, Rafael, additional, Fernández-Navarro, Mónica, additional, Fernández-Quintela, Alfredo, additional, Faria, Adriana Ferreira, additional, Fitó, Montserrat, additional, Fogher, Corrado, additional, Foglia, Patrizia, additional, Franconi, Flavia, additional, Fregapane, Giuseppe, additional, Fujimoto, Kazuma, additional, Fujise, Takehiro, additional, Furneri, Pio Maria, additional, Gallardo, Visitación, additional, Galletti, Patrizia, additional, Galvez, Julio, additional, Garcia, Aranzazu, additional, García, I.M., additional, García-Luna, Pedro P., additional, Garrido-Fernández, Antonio, additional, Garrigues, Salvador, additional, Geelen, Math J.H., additional, Geladopoulos, Taxiarchis, additional, Giamarellos-Bourboulis, Evangelos J., additional, Frenich, Antonia Garrido, additional, Galaris, Dimitrios, additional, Gilani, Anwarul Hassan, additional, Gill, Chris I.R., additional, Giovannini, Claudio, additional, Glatzle, Jörg, additional, Gnoni, Gabriele V., additional, Gomes, Tommaso, additional, Gómez-Rico, Aurora, additional, Gonos, Efstathios S., additional, Gonzalez, Carlos A., additional, Goya, Luis, additional, Grosovski, Maria, additional, Gutiérrez, Guillermo Rodriguez, additional, Hartmann, Marie-Andrée, additional, Hashim, Yumi Z., additional, Hu, Xiuli, additional, Ieri, Francesca, additional, Iliodromitis, Efstathios K., additional, Iwakiri, Ryuichi, additional, Juan, M. Emilia, additional, Kalogeropoulos, Nick, additional, Kalua, Curtis, additional, Khan, Arif-ullah, additional, Khymenets, Olha, additional, Kosti, Rena, additional, Kotsiou, Antonia, additional, Kremastinos, Dimitrios Th., additional, Lafont, Fernando, additional, Laganà, Aldo, additional, Landete, Jose Maria, additional, La Pera, Lara, additional, Lapucci, Chiara, additional, Lavermicocca, Paola, additional, Léger, Claude Louis, additional, Lehotay, Steven J., additional, Leone, Alessandro, additional, Liu, Jun, additional, Turco, Vincenzo Lo, additional, Lopez, Sergio, additional, de Cerain, Adela Lopez, additional, de Felipe, Felix Lopez, additional, López-Feria, Silvia, additional, de la Serrana, Herminia López-Garcia, additional, López-López, Antonio, additional, López-Martinez, Maria Carmen, additional, Lopez-Miranda, Jose, additional, La Torre, Giovanna Loredana, additional, Lucas, Ricardo, additional, Lupiáñez, José A., additional, Luque, Rafael, additional, Macciola, Vincenzo, additional, Madar, Zecharia, additional, Mafra, Isabel, additional, Magrì, Andrea D., additional, Magrì, Antonio L., additional, Maiuri, Maria Chiara, additional, Malaisse, Willy J., additional, Mañas, Mariano, additional, Mandarim-de-Lacerda, Carlos Alberto, additional, Manna, Caterina, additional, Mannina, Luisa, additional, Mannino, Saverio, additional, Marinas, Alberto, additional, Marinas, Jose M., additional, Marini, Federico, additional, Markaki, Panagiota, additional, Martín, M. Angeles, additional, Martínez, María Alba, additional, Martinez-Gonzalez, Miguel A., additional, Martínez-Gracia, María Victoria, additional, Martinez-Martos, José Manuel, additional, Martínez-Victoria, Emilio, additional, Masella, Roberta, additional, Massaro, Marika, additional, Mastovska, Katerina, additional, Mateos, Raquel, additional, Mazzoni, Michela, additional, Menéndez-Menéndez, Javier, additional, Medina, Eduardo, additional, Medina, Jose M., additional, Micol, Vicente, additional, Mikros, Emmanuel, additional, Mitjavila, Maria Teresa, additional, Montaño, Alfredo, additional, Morales, Juan Carlos, additional, Morcillo, Sonsoles, additional, Moreno, Juan José, additional, Moreno, Paola, additional, Moret, Sabrina, additional, Moros, Javier, additional, Morozzi, Guido, additional, Motilva, Maria-Jose, additional, Muñoz, Rosario, additional, Muriana, Francisco J.G., additional, Napoli, Daniela, additional, Napolitano, Alessandra, additional, Nassar, Faris, additional, Nasti, Raffaella, additional, Natali, Francesco, additional, Natalini, Paolo, additional, Nunes, Cláudia S., additional, Nychas, George, additional, Oliveira, M. Beatriz P.P., additional, Orihara, Yutaka, additional, Ortega, Almudena, additional, Ortega-García, Francisca, additional, Osada, Jesús, additional, Özdemir, Durmuş, additional, Öztürk, Betül, additional, Pacheco, Yolanda M., additional, Paice, Alistair G., additional, Palmerini, Carlo A., additional, Panagiotakos, Demosthenes, additional, Panagou, E.Z., additional, Panzella, Lucia, additional, Papoti, V.T., additional, Paradiso, Vito Michele, additional, Pariente, José Antonio, additional, Patel, Vinood B., additional, Peinado, M. Ángeles, additional, Pellicanò, Teresa Maria, additional, Peragon, Juan, additional, Perez-Jimenez, Francisco, additional, Perez-Martinez, Pablo, additional, Perona, Javier Sanchez, additional, Piperno, Anna, additional, Planas, Joana M., additional, Pollicino, Donatella, additional, Polzonetti, Valeria, additional, Populin, Tiziana, additional, Portillo, Maria P., additional, Pozo, David, additional, Prenzler, Paul, additional, Prieto, Pablo G., additional, Pucciarelli, Stefania, additional, Puel, Caroline, additional, Puertollano, Elena, additional, Puertollano, María A., additional, Quesada-Granados, Jose Javier, additional, Rajendram, Rajkumar, additional, Ramírez-Expósito, María Jesús, additional, Ramos, Sonia, additional, Ramos-Martos, Natividad, additional, Randazzo, Cinzia L., additional, Rando, Rossana, additional, Reiter, Russel J., additional, Rejano, Luis, additional, Rhee, Hae-Ik, additional, Robards, Kevin, additional, Rodriguez, Hector, additional, Rodríguez-Cabezas, Maria Elena, additional, Rodríguez-Manero, Moises, additional, Rodríguez-Méndez, María L., additional, Rodríguez, Rosalía, additional, Rodriguez-Rodriguez, Rosalia, additional, Romani, Annalisa, additional, Romero, Concepción, additional, Romero, Maria-Paz, additional, Romero-Gonzalez, Roberto, additional, Rose, Martin, additional, Rossi, Mauro, additional, Rotondi, Annalisa, additional, Rowland, Ian R., additional, Ruiz, Adolfina, additional, Ruiz-Gutiérrez, Valentina, additional, Russo, Francesco, additional, Ryan, Danielle, additional, Sabatini, Nadia, additional, Sacco, Antonio, additional, Sahan, Yasemin, additional, Saitta, Marcello, additional, Salvador, Maria Desamparados, additional, Samperi, Roberto, additional, Samaniego-Sánchez, Cristina, additional, Sánchez, Antonio Higinio, additional, Sánchez-Navarro, Maria Rosa, additional, Sancho, Verónica, additional, Santos-González, Mónica, additional, Saraiva, Jorge A., additional, Scampicchio, Matteo, additional, Scazzocchio, Beatrice, additional, Schmitt, Christoph A., additional, Schwartz, Betty, additional, Sciuto, Sebastiano, additional, Scoditti, Egeria, additional, Seabra, Rosa M., additional, Sebastiani, Luca, additional, Segre, Anna Laura, additional, Segura, Antonio, additional, Servili, Maurizio, additional, Shiraishi, Ryosuke, additional, Siculella, Luisa, additional, Simão, Andréa Colado, additional, Sindona, Giovanni, additional, Sivakumar, Ganapathy, additional, Skaltsounis, Alexios-Leandros, additional, Smith, Amos B., additional, Spatafora, Carmela, additional, Sperry, Jeffrey B., additional, Soares, Mario J., additional, Soriguer, Federico, additional, Srirajaskanthan, Rajaventhan, additional, Stitia, Naïm, additional, Tabernero, Arantxa, additional, Tagarelli, Antonio, additional, Tai, Fuju, additional, Tamborrino, Antonia, additional, Tassou, C.C., additional, Tesseromatis, Christine, additional, Todeschini, Roberto, additional, Torrecilla, Jose S., additional, Trikib, Saïda, additional, Tringali, Corrado, additional, Tsakiris, Ioannis N., additional, Tsatsakis, Aristidis M., additional, Tsimidou, M.Z., additional, Uccella, Nicola A., additional, Urbano, Francisco J., additional, Valcarcel, Miguel, additional, Valencia-Serrano, Félix, additional, Valentão, Patrícia, additional, Valverde, Isabel, additional, Varela, Lourdes M., additional, Varì, Rosaria, additional, Simas Vaz, Fernando Antonio, additional, Vettorazzi, Ariane, additional, Vichi, Stefania, additional, Vidal, José Luis Martínez, additional, Villalba, José M., additional, Villalba, Mayte, additional, Villanueva-Peñacarrillo, María L., additional, Vincenzetti, Silvia, additional, Vita, Alberto, additional, Vlahov, Giovanna, additional, Wang, Wei, additional, Weisberg, Edmund, additional, Wenzel, Uwe, additional, Won, Se-Ra, additional, Wu, Bin, additional, Yago, María Dolores, additional, Zabaras, Dimitrios, additional, Zappia, Vincenzo, additional, Zarzuelo, Antonio, additional, and Zhang, Luyong, additional

Published
2010
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21. Plasma extracellular superoxide dismutase concentration, allelic variations in the SOD3 gene and risk of myocardial infarction and all-cause mortality in people with type 1 and type 2 diabetes

Author

Mohammedi, Kamel, Bellili-Muñoz, Naïma, Marklund, Stefan, Driss, Fathi, Le Nagard, Hervé, Patente, Thiago, Fumeron, Frédéric, Roussel, Ronan, Hadjadj, Samy, Marre, Michel, Velho, Gilberto, Service d'endocrinologie, diabétologie et nutrition [CHU Bichat], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Immunologie et Cancérologie Intégratives (CRC - Inserm U1138), Centre de Recherche des Cordeliers (CRC), Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Medical Biosciences, Umeå University, Centre de recherche biomédicale Bichat-Beaujon (CRB3), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de biochimie hormonale, métabolique et génétique, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratório de Endocrinologia Celular e Molecular (LIM-25), Faculdade de Medicina da Universidade de São Paulo (FMUSP), Sorbonne Paris Cite, Université Paris Diderot - Paris 7 (UPD7), Service d'Endocrinologie et Diabétologie, Centre hospitalier universitaire de Poitiers (CHU Poitiers), Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques ( IRTOMIT), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale (INSERM), CIC - Poitiers, Université de Poitiers-Centre hospitalier universitaire de Poitiers (CHU Poitiers)-Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 ( UPD7 ), Immunologie et Cancérologie Intégratives ( CRC - Inserm U1138 ), Centre de Recherche des Cordeliers ( CRC ), Université Paris Diderot - Paris 7 ( UPD7 ) -École pratique des hautes études ( EPHE ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Paris Diderot - Paris 7 ( UPD7 ) -École pratique des hautes études ( EPHE ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), University of Umeå, Centre de recherche biomédicale Bichat-Beaujon ( CRB3 ), Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Infection, Antimicrobiens, Modélisation, Evolution ( IAME ), Université Paris 13 ( UP13 ) -Université Paris Diderot - Paris 7 ( UPD7 ) -Université Sorbonne Paris Cité ( USPC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Faculdade de Medicina da Universidade de São Paulo ( FMUSP ), Université Paris Diderot - Paris 7 ( UPD7 ), Université de Poitiers-Centre hospitalier universitaire de Poitiers ( CHU Poitiers ), Ischémie Reperfusion en Transplantation d’Organes Mécanismes et Innovations Thérapeutiques ( IRTOMIT ), Université de Poitiers-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Poitiers-Centre hospitalier universitaire de Poitiers ( CHU Poitiers ) -Direction Générale de l'Organisation des Soins (DGOS)-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris Diderot - Paris 7 (UPD7)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris]-Université Paris Diderot - Paris 7 (UPD7), Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7)-École pratique des hautes études (EPHE)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Poitiers, Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-École pratique des hautes études (EPHE), and BMC, BMC

Subjects
Adult, Male, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Myocardial Infarction, Endocrinology and Diabetes, Cohort Studies, Risk Factors, Diabetes Mellitus, Humans, Cardiac and Cardiovascular Systems, Prospective Studies, Mortality, Alleles, Original Investigation, Kardiologi, [ SDV ] Life Sciences [q-bio], Superoxide Dismutase, Genetic Variation, Extracellular Fluid, Middle Aged, SOD3, [SDV] Life Sciences [q-bio], Oxidative Stress, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Endokrinologi och diabetes, Female, Cardiology and Cardiovascular Medicine, Biomarkers, Follow-Up Studies
Abstract

Background Oxidative stress is involved in development of diabetes complications. Extracellular superoxide dismutase (EC-SOD, SOD3) is a major extracellular antioxidant enzyme and is highly expressed in arterial walls. Advanced oxidation protein products (AOPP) and 8-iso-prostaglandin (isoprostane) are markers of oxidative stress. We investigated association of SOD3 gene variants, plasma concentrations of EC-SOD, AOPP and isoprostane with myocardial infarction and mortality in diabetic patients. Methods We studied three cohorts designed to evaluate the vascular complications of diabetes: the GENEDIAB study (469 participants with type 1 diabetes at baseline; follow-up data for 259 participants), the GENESIS study (603 participants with type 1 diabetes at baseline; follow-up data for 525 participants) and the DIABHYCAR study (3137 participants with type 2 diabetes at baseline and follow-up). Duration of follow-up was 9, 5, and 5 years, respectively. Main outcome measures were incidence of myocardial infarction, and cardiovascular and total mortality during follow-up. Six single nucleotide polymorphisms in the SOD3 locus were genotyped in the three cohorts. Plasma concentrations of EC-SOD, AOPP, and isoprostane were measured in baseline samples of GENEDIAB participants. Results In GENEDIAB/GENESIS pooled cohorts, the minor T-allele of rs2284659 variant was inversely associated with the prevalence at baseline (Odds Ratio 0.48, 95% CI 0.29–0.78, p = 0.004) and the incidence during follow-up of myocardial infarction (Hazard Ratio 0.58, 95% CI 0.40–0.83, p = 0.003) and with cardiovascular (HR 0.33, 95% CI 0.08–0.74, p = 0.004) and all-cause mortality (HR 0.44, 95% CI 0.21–0.73, p = 0.0006). The protective allele was associated with higher plasma EC-SOD and lower plasma AOPP concentrations in GENEDIAB. It was also inversely associated with incidence of myocardial infarction (HR 0.75, 95% CI 0.59–0.94, p = 0.01) and all-cause mortality (HR 0.87, 95% CI 0.79–0.97, p = 0.008) in DIABHYCAR. Conclusions The T-allele of rs2284659 in the promoter of SOD3 was associated with a more favorable plasma redox status and with better cardiovascular outcomes in diabetic patients. Our results suggest that EC-SOD plays an important role in the mechanisms of vascular protection against diabetes-related oxidative stress. Electronic supplementary material The online version of this article (doi:10.1186/s12933-014-0163-2) contains supplementary material, which is available to authorized users.

Published
2015
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22. Effect of rapid desensitization on platelet inhibition and basophil activation in patients with aspirin hypersensitivity and coronary disease

Author

Manzo-Silberman, Stéphane, primary, Nicaise-Roland, Pascale, additional, Neukirch, Catherine, additional, Tubach, Florence, additional, Huisse, Marie-Geneviève, additional, Chollet-Martin, Sylvie, additional, Abergel, Hélène, additional, Driss, Fathi, additional, Alfaiate, Toni, additional, Ajzenberg, Nadine, additional, and Steg, Philippe Gabriel, additional

Published
2016
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24. Docosahexaenoic acid, protectin synthesis: relevance against atherothrombogenesis

Author

Lagarde, Michel, Liu, Miao, Véricel, Evelyne, Calzada, Catherine, Chen, Ping, Driss, Fathi, Guichardant, Michel, Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Centre de recherche biomédicale Bichat-Beaujon (CRB3), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Inserm, Ministry of Education and Research, ANR, and Carnot LISA institute., Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL)

Subjects
Blood platelets, Leukocytes, lipids (amino acids, peptides, and proteins), Lipoxygenases, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, Cyclooxygenases
Abstract

International audience; DHA is an abundant nutrient from marine lipids: its specific biological effects have been investigated in human volunteers, taking into consideration the dose effects. We report herein that, at dosages below 1 g/d, DHA proved to be effective in lowering blood platelet function and exhibited an 'antioxidant' effect. However, this was no longer the case following 1*6 g/d, showing then a U-shape response. The antioxidant effect has been observed in platelets as well as LDL, of which the redox status is assumed to be crucial in their relationship with atherosclerosis. Second, the oxygenated products of DHA, especially protectins produced by lipoxygenases, have been considered for their potential to affect blood platelets and leucocytes. It is concluded that DHA is an interesting nutrient to reduce atherothrombogenesis, possibly through complementary mechanisms involving lipoxygenase products of DHA.

Published
2013
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25. ОПРЕДЕЛЕНИЕ ЭФФЕКТИВНОСТИ И БЕЗОПАСНОСТИ ДЛИТЕЛЬНОГО ПРИМЕНЕНИЯ ВНУТРИВЕННО ПРЕПАРАТА ЖИРОВОЙ ЭМУЛЬСИИ ДЕРИВАТА ОЛИВКОВОГО МАСЛА У ПАЦИЕНТОВ ПЕДИАТРИЧЕСКОГО ПРОФИЛЯ

Author

GOULET OLIVIER, DE POTTER SOPHIE, ANTEBI HELENA, DRISS FATHI, COLOMB VIRGINIE, BEREZIAT GILBERT, ALCINDOR LOUIS-GERALD, CORRIOL ODILE, LE BRUN ALEXIA, DUTOT GUY, FORGET DOMINIQUE, PERENNEC VERONIQUE, and RICOUR CLAUDE

Subjects
ЖИРОВАЯ ЭМУЛЬСИЯ ДЛЯ ВНУТРИВЕННОГО ВВЕДЕНИЯ,INTRAVENOUS FAT EMULSION,ЛИПИДЫ,LIPIDS,ОЛИВКОВОЕ МАСЛО,OLIVE OIL,МАСЛО СОЕВЫХ БОБОВ,SOYBEAN OIL,ПАРЕНТЕРАЛЬНОЕ ПИТАНИЕ,PARENTERAL NUTRITION,ПЕДИАТРИЯ,PEDIATRICS,ДЕТИ,CHILDREN,ЖИРОВА ЕМУЛЬСіЯ ДЛЯ ВНУТРіШНЬОВЕННОГО ВВЕДЕННЯ,ЛіПіДИ,МАСЛИНОВА ОЛіЯ,ОЛіЯ СОєВИХ БОБіВ,ПАРЕНТЕРАЛЬНЕ ХАРЧУВАННЯ,ПЕДіАТРіЯ,ДіТИ
Abstract

Основание. Новый препарат жировой эмульсии для внутривенного введения (нВЖЭ) изготовлен из смеси масел соевых бобов и масла олив и содержит только длинноцепочечные триацилглицериды, с низким содержанием полиненасыщенных жирных кислот (20 %) и 60% содержанием мононенасыщенных жирных кислот. Целью рандомизированного двойного слепого исследования было определение эффективности и безопасности применения нового препарата ВЖЭ у детей в сравнении с контрольной группой, которая получала жировую эмульсию деривата соевых бобов (ЖЭДСБ). Дизайн исследования. 18 детей получали в течение 2 мес. 24 % энергетического обеспечения небелкового происхождения (1,80 г кг-1 день-1) или в виде нового препарата ВЖЭ, или ЖЭДСБ. Определение профиля проводилось в такие дни: -30, 0, 30 и 60-й, также оценивались изменения (день 60-й день 0-й) методом вариативного анализа. Результаты. Не отмечено существенной разницы в показателях содержания триацилглицерида, аполипопротеинов А-І и В или холестерина ЛПВП в 2 группах, причем на 60-й день исследования показатели общего холестерина и холестерина ЛПНП были выше в группе, где применялась ЖЭДСБ. Профиль липопротеидов 20:4n-6 в эритроцитарных мембранах не изменялся существенно, неизмененным оставалось также соотношение фракций 20:3n-9 и 20:4n-6. На 60-й день уровень фракции липопротеидов 18:1n-9 был значительно выше у детей, которые получали нВЖЭ, показатели Sn-6 > С18 + 18:3n-6 относительно 18:2n-6 были на уровне 2,20 ± 0,09 в группе детей, которые получали нВЖЭ, и 1,33 ± 0,16 в группе, в которой применяли ЖЭДСБ; показатели Sn-3 > С18 были на уровне 3,83 ± 0,30 в группе детей, которые получали нВЖЕ, и 4,03 ± 0,33 в группе, в которой применяли ЖЭДСБ. Индекс перекисного окисления липидов был значительно ниже у детей, которые получали нВЖЭ. Выводы. Препарат нВЖЭ хорошо переносится при использовании у пациентов педиатрического профиля, помогает поддерживать на необходимом уровне показатели незаменимых жирных кислот (EFA-статус) и может использоваться как инфузийный препарат, которому следует отдавать предпочтение при применении с целью предупреждения процессов перекисного окисления липидов по сравнению с ЖЭДСБ., Background. A new intravenous lipid emulsion (ILE) prepared from a mixture of soybean and olive oils contains only long-chain triacylglycerols, with a low proportion (20 %) of polyunsaturated fatty acids and 60 % monounsaturated fatty acids. Objective. The goal of this randomized, double-blind clinical trial was to assess in children the efficacy and safety of this new ILE compared with a control group receiving a soybean-oil emulsion. Design. Eighteen children received for 2 mo 24 % of nonprotein energy (1.80 g kg-1 d-1) either as the new ILE or a soybean oil-based emulsion. Assessments were performed on days -30, 0, 30, and 60 and the changes (day 60 day 0) assessed by analysis of variance. Results. There were no significant differences in triacylglycerol, apolipoproteins A-I and B, or HDL cholesterol between the 2 groups, whereas total and LDL cholesterol were higher in the soybean oil group on day 60. The pattern of 20:4n-6 in erythrocyte membranes did not change significantly, nor did the ratio of 20:3n-9 to 20:4n-6. On day 60, 18:1n-9 was significantly higher in the olive oil group, the ratio of Sn-6 > C18 + 18:3n-6 to 18:2n-6 was 2.20 ± 0.09 in the olive oil group and 1.33 ± 0.16 in the soybean-oil group, and Sn-3 > C18 was 3.83 ± 0.30 in the olive oil group and 4.03 ± 0.33 in the soybean-oil group. The peroxidation index was lower after the olive oil treatment. Conclusions. The olive oil-based emulsion was well tolerated, maintained a normal EFA status, and may be more suitable for prevention of lipid peroxidation than the soybean-oil-based emulsion.

Published
2011

27. Relationships between plasma and erythrocyte fatty acids in the de novo lipogenesis pathway, and metabolic disorders in French elderly patients

Author

Henry, Olivier, primary, Vaysse, Carole, additional, Lopez, Carlos, additional, Driss, Fathi, additional, Fonseca, Isabelle, additional, Simon, Noëmie, additional, Guillou, Céline Le, additional, Masselin-Silvin, Sylvie, additional, David, Jean-Philippe, additional, Combe, Nicole, additional, and Mendy, François, additional

Published
2015
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29. Manganese Superoxide Dismutase (SOD2) Polymorphisms, Plasma Advanced Oxidation Protein Products (AOPP) Concentration and Risk of Kidney Complications in Subjects with Type 1 Diabetes

Author

Mohammedi, Kamel, primary, Bellili-Muñoz, Naïma, additional, Driss, Fathi, additional, Roussel, Ronan, additional, Seta, Nathalie, additional, Fumeron, Frédéric, additional, Hadjadj, Samy, additional, Marre, Michel, additional, and Velho, Gilberto, additional

Published
2014
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30. From tissue iron retention to low systemic haemoglobin levels, new pathophysiological biomarkers of human abdominal aortic aneurysm

Author

Madrigal-Matute, Julio, primary, Blanco-Colio, Luis M., primary, Esteban-Salan, Margarita, primary, Torres-Fonseca, Monica, primary, Lefebvre, Thibault, primary, Delbosc, Sandrine, primary, Laustsen, Jesper, primary, Driss, Fathi, primary, de Ceniga, Melina, primary, Gouya, Laurent, primary, Egido, Jesus, primary, Meilhac, Olivier, primary, Michel, Jean-Baptiste, primary, Martin-Ventura, Jose L., primary, Martinez-Pinna, Roxana, additional, Lindholt, Jes S., additional, and Weiss, Günter, additional

Published
2014
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32. Relationships between plasma and erythrocyte fatty acids in the de novo lipogenesis pathway, and metabolic disorders in French elderly patients.

Author

Henry, Olivier, Vaysse, Carole, Lopez, Carlos, Driss, Fathi, Fonseca, Isabelle, Simon, Noëmie, Guillou, Céline Le, Masselin‐Silvin, Sylvie, David, Jean‐Philippe, Combe, Nicole, and Mendy, François

Subjects
LIPID synthesis, CARDIOVASCULAR diseases risk factors, DISEASES, ERYTHROCYTES, METABOLIC disorders, PATIENTS
Abstract

Undernutrition has been identified as a major contributing factor to morbidity and mortality in hospitalized aged patients. The lipid calorie undernutrition may lead to de novo lipogenesis (DNL); among the endogenous fatty acids, 16: 1(n-9) and 18:1 (n-7) have been previously associated with a higher risk of sudden cardiac arrest (SCA). The aim was to examine possible associations between the fatty acids in the DNL pathway present in both plasma and erythrocytes of 188 patients aged 84 ± 7 years (48 men and 140 women) entering the geriatric department for evaluation and rehabilitation, and their metabolic disorders. The 18:1(n-7) content in plasma cholesteryl esters (CE) was significantly higher in men (1.67 vs. 1.58% in women; P < 0.05). An inverse relationship was found between 18:1 (n-7) and the two precursors of essential fatty acids (EFA), that is linoleic acid [18:2 (n-6); LA] and alpha-linolenic acid [18:3 (n-3); ALA]. Moreover, an inverse relationship was found between 16: 1(n-9) and LA. Sixty-four percent of men suffered from dysglycemia versus 46% of women ( P < 0.05). These patients were characterized by significantly higher content (+37%) of 16:1(n-7) which derives mostly from DNL. Prevalence of metabolic syndrome (MetS) was 30-40%, associated with a higher level of 18:0, regardless of sex. Practical applications: Improving nutrition for the elderly patients is a key challenge for rehabilitation. The diet of our oldest old patients was low in total calories and low in fat; it might be partly responsible for the levels of fatty acids from DNL observed. Further study is needed to investigate whether it is possible to reduce both 18:1 (n-7) and 16: 1(n-9) levels. We propose to test the improvement of diet for our oldest old patients by increasing fat up to 70 g/d which is the lower limit of the recommended amounts. Simplified summary of the main objective: to examine potential relationships between the fatty acids in the DNL pathway and metabolic disorders (dysglycemia and MetS), factors of the cardiovascular risk in the elderly patients by sex. [ABSTRACT FROM AUTHOR]

Published
2016
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35. Effect of rapid desensitization on platelet inhibition and basophil activation in patients with aspirin hypersensitivity and coronary disease.

Author

Manzo-Silberman, Stéphane, Nicaise-Roland, Pascale, Neukirch, Catherine, Tubach, Florence, Huisse, Marie-Geneviève, Chollet-Martin, Sylvie, Abergel, Hélène, Driss, Fathi, Alfaiate, Toni, Ajzenberg, Nadine, and Steg, Philippe Gabriel

Abstract

To determine antiplatelet efficacy after desensitization in patients with a history of aspirin hypersensitivity.

Published
2017
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41. NAD(P)H Oxidase Nox-4 Mediates 7-Ketocholesterol-Induced Endoplasmic Reticulum Stress and Apoptosis in Human Aortic Smooth Muscle Cells

Author

Pedruzzi, Eric, primary, Guichard, Cécile, additional, Ollivier, Véronique, additional, Driss, Fathi, additional, Fay, Michèle, additional, Prunet, Céline, additional, Marie, Jean-Claude, additional, Pouzet, Cécile, additional, Samadi, Mohammad, additional, Elbim, Carole, additional, O'Dowd, Yvonne, additional, Bens, Marcelle, additional, Vandewalle, Alain, additional, Gougerot-Pocidalo, Marie-Anne, additional, Lizard, Gérard, additional, and Ogier-Denis, Eric, additional

Published
2004
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44. From tissue iron retention to low systemic haemoglobin levels, new pathophysiological biomarkers of human abdominal aortic aneurysm.

Author

Martinez-Pinna, Roxana, Lindholt, Jes S., Madrigal-Matute, Julio, Blanco-Colio, Luis M., Esteban-Salan, Margarita, Torres-Fonseca, Monica Maria, Lefebvre, Thibault, Delbosc, Sandrine, Laustsen, Jesper, Driss, Fathi, de Ceniga, Melina Vega, Gouya, Laurent, Weiss, Günter, Egido, Jesus, Meilhac, Olivier, Michel, Jean-Baptiste, and Martin-Ventura, Jose L.

Published
2014
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45. Docosahexaenoic acid, protectin synthesis: relevance against atherothrombogenesis.

Author

Lagarde, Michel, Liu, Miao, Véricel, Evelyne, Calzada, Catherine, Chen, Ping, Driss, Fathi, and Guichardant, Michel

Abstract

DHA is an abundant nutrient from marine lipids: its specific biological effects have been investigated in human volunteers, taking into consideration the dose effects. We report herein that, at dosages below 1 g/d, DHA proved to be effective in lowering blood platelet function and exhibited an ‘antioxidant’ effect. However, this was no longer the case following 1·6 g/d, showing then a U-shape response. The antioxidant effect has been observed in platelets as well as LDL, of which the redox status is assumed to be crucial in their relationship with atherosclerosis. Second, the oxygenated products of DHA, especially protectins produced by lipoxygenases, have been considered for their potential to affect blood platelets and leucocytes. It is concluded that DHA is an interesting nutrient to reduce atherothrombogenesis, possibly through complementary mechanisms involving lipoxygenase products of DHA. [ABSTRACT FROM PUBLISHER]

Published
2014
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46. Manganese Superoxide Dismutase (SOD2) Polymorphisms, Plasma Advanced Oxidation Protein Products (AOPP) Concentration and Risk of Kidney Complications in Subjects with Type 1 Diabetes.

Author

Mohammedi, Kamel, Bellili-Muñoz, Naïma, Driss, Fathi, Roussel, Ronan, Seta, Nathalie, Fumeron, Frédéric, Hadjadj, Samy, Marre, Michel, and Velho, Gilberto

Subjects
MANGANESE oxides, SUPEROXIDE dismutase, GENETIC polymorphisms, BLOOD plasma, PROTEIN expression, KIDNEY diseases, TYPE 1 diabetes, DISEASE complications
Abstract

Aims: Oxidative stress is involved in the pathophysiology of diabetic nephropathy. Manganese superoxide dismutase (SOD2) catalyses the dismutation of superoxide, regulates the metabolism of reactive oxygen species in the mitochondria and is highly expressed in the kidney. Plasma concentration of advanced oxidation protein products (AOPP), a marker of oxidative stress, was found to be increased in patients with kidney disease. We investigated associations of SOD2 allelic variations, plasma SOD activity and AOPP concentration with diabetic nephropathy in type 1 diabetic subjects. Methods: Eight SNPs in the SOD2 region were analysed in 1285 Caucasian subjects with type 1 diabetes from the SURGENE prospective study (n = 340; 10-year follow-up), GENESIS (n = 501) and GENEDIAB (n = 444) cross-sectional studies. Baseline plasma concentration of AOPP and SOD activity were measured in GENEDIAB participants. Hazard ratio (HR) and odds ratio (OR) were determined for incidence and prevalence of nephropathy. Analyses were adjusted or stratified by retinopathy stages. Results: In the SURGENE cohort, the T-allele of rs4880 (V16A) was associated with the incidence of renal events (new cases, or the progression to a more severe stage of nephropathy; HR 1.99, 95% CI 1.24–3.12, p = 0.004) and with the decline in estimated glomerular filtration rate (eGFR) during follow-up. Similar associations were observed for rs2758329 and rs8031. Associations were replicated in GENESIS/GENEDIAB cohorts, in the subset of participants without proliferative retinopathy, and were confirmed by haplotype analyses. Risk allele and haplotype were also associated with higher plasma AOPP concentration and lower SOD activity. Conclusions: SOD2 allelic variations were associated with the incidence and the progression of diabetic nephropathy, with a faster decline in eGFR and with plasma AOPP concentration and SOD activity in subjects with type 1 diabetes. These results are consistent with a role for SOD2 in the protection against oxidative stress and kidney disease in type 1 diabetes. [ABSTRACT FROM AUTHOR]

Published
2014
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50. Change in C-reactive protein levels and FEV1 decline: A longitudinal population-based study.

Author

Shaaban, Rafea, Kony, Sabine, Driss, Fathi, Leynaert, Bénédicte, Soussan, David, Pin, Isabelle, Neukirch, Françoise, and Zureik, Mahmoud

Abstract

Summary: Reduced pulmonary function is an important predictor of cardiovascular morbidity and mortality. The mechanisms underlying this association are unknown but may involve systemic inflammation. We assessed the cross-sectional and longitudinal relationships between C-reactive protein (CRP) levels and forced expiratory volume in 1s (FEV1) and its decline in the general population, over a period of 8.5 years. The analyzes were based on 531 subjects (mean age at baseline: 37±7 years, 50% women and 42% non-smokers), recruited at two French centers participating in the European Community Respiratory Health Survey. Lung function was expressed as a percentage of predicted FEV1. CRP was measured centrally, by means of a highly sensitive assay. In cross-sectional analysis, FEV1 as a % of predicted values was negatively associated with serum CRP concentration (). Multivariate adjustment did not alter these results (). In longitudinal analysis, annual FEV1 decline tended to increase from the lower to the upper tertile for baseline CRP concentration but the association was borderline significant (). Mean values of annual FEV1 decline were 26±32, 31±32, and 34±32ml/year for the lower, middle and upper tertiles of baseline CRP concentration, respectively, after adjusting for potential confounders (). Changes in CRP levels during follow-up were associated with annual FEV1 decline. The mean annual FEV1 declines in subjects with increasing CRP, in those with stable CRP and in those with decreasing CRP were 36±31, 30±31 and 24±31ml/year, respectively (). These findings were not affected by adjustment for potential confounders (). In conclusion, increases in CRP levels over time were associated with a steeper FEV1 decline. [Copyright &y& Elsevier]

Published
2006
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