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7. Clinical validation of a 13-lead electrocardiogram derived from a self-applicable 3-lead recording for diagnosis of myocardial supply ischaemia and common non-ischaemic electrocardiogram abnormalities at rest

Author

Van Heuverswyn, Frederic, primary, De Schepper, Céline, additional, De Buyzere, Marc, additional, Coeman, Mathieu, additional, De Pooter, Jan, additional, Drieghe, Benny, additional, Kayaert, Peter, additional, Timmers, Liesbeth, additional, Gevaert, Sofie, additional, Calle, Simon, additional, Kamoen, Victor, additional, Demolder, Anthony, additional, El Haddad, Milad, additional, and Gheeraert, Peter, additional

Published
2022
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12. iFR uncovers profound but mostly reversible ischemia in CTOs and helps to optimize PCI results

Author

Kayaert, Peter, primary, Coeman, Mathieu, additional, Drieghe, Benny, additional, Bennett, Johan, additional, McCutcheon, Keir, additional, Dens, Jo, additional, Ungureanu, Claudiu, additional, Zivelonghi, Carlo, additional, Agostoni, Pierfrancesco, additional, Bataille, Yoann, additional, de Hemptinne, Quentin, additional, Gevaert, Sofie, additional, De Pauw, Michel, additional, and Haine, Steven, additional

Published
2020
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17. Assessing the landscape of percutaneous coronary chronic total occlusion treatment in Belgium and Luxembourg

Author

Maeremans, Joren, Kayaert, Peter, Bataille, Yoann, Bennett, Johan, Ungureanu, Claudiu, Haine, Steven, Vandendriessche, Tom, Sonck, Jeroen, Scott, Benjamin, Coussement, Patrick, Dendooven, Daniël, Pereira, Bruno, Frambach, Peter, Janssens, Luc, Debruyne, Philippe, Van Mieghem, Carlos, Barbato, Emanuele, Cornelis, Kristoff, Stammen, Francis, De Vroey, Frederic, Vercauteren, Steven, Drieghe, Benny, Aminian, Adel, Debrauwere, Jan, Carlier, Stephane, Coosemans, Mark, Van Reet, Bert, Vandergoten, Peter, Dens, Jo Andre, (On behalf of the BWGCTO Investigators), Cardio-vascular diseases, Clinical sciences, Cardiology, Internal Medicine Specializations, Vrije Universiteit Brussel, Maeremans, Joren, Kayaert, Peter, Bataille, Yoann, Bennett, Johan, Ungureanu, Claudiu, Haine, Steven, Vandendriessche, Tom, Sonck, Jeroen, Scott, Benjamin, Coussement, Patrick, Dendooven, Daniël, Pereira, Bruno, Frambach, Peter, Janssens, Luc, Debruyne, Philippe, Van Mieghem, Carlo, Barbato, Emanuele, Cornelis, Kristoff, Stammen, Franci, De Vroey, Frederic, Vercauteren, Steven, Drieghe, Benny, Aminian, Adel, Debrauwere, Jan, Carlier, Stéphane, Coosemans, Mark, Van Reet, Bert, Vandergoten, Peter, and Dens, Jo Andre

Subjects
Male, medicine.medical_specialty, Percutaneous, Luxembourg, medicine.medical_treatment, Population, 030204 cardiovascular system & hematology, Total occlusion, 03 medical and health sciences, 0302 clinical medicine, Percutaneous Coronary Intervention, Belgium, medicine, Journal Article, Humans, 030212 general & internal medicine, Registries, education, Adverse effect, chronic total occlusion, education.field_of_study, business.industry, Percutaneous coronary intervention, Mean age, General Medicine, Middle Aged, Surgery, Dissection, Treatment Outcome, Conventional PCI, Female, Human medicine, Cardiology and Cardiovascular Medicine, business, in-hospital outcomes
Abstract

Background: Important developments in materials, devices, and techniques have improved outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI), and resulted in a growing interest in CTO-PCI. The Belgian Working Group on Chronic Total Occlusions (BWGCTO) working group aims to assess the evolution within the CTO-PCI landscape over the next years. Methods: From May 2016 onwards, patients undergoing CTO-PCI were included in the BWGCTO registry by 15 centres in Belgium and Luxemburg. Baseline, angiographic, and procedural data were collected. Here, we report on the one-year in-hospital outcomes. Results: Over the course of one year, 411 procedures in 388 patients were included with a mean age of 64 ± 11 years. The majority were male (81%). Relatively complex CTOs were treated (Japanese CTO score =2.2 ± 1.2) with a high procedure success rate (82%). Patient- and lesion-wise success rates were 83 and 85%, respectively. Major adverse in-hospital events were acceptably low (3.4%). Antegrade wire escalation technique was applied most frequently (82%). On the other hand, antegrade dissection and re-entry and retrograde strategies were more frequently applied in higher volume centres and successful for lesions with higher complexity. Conclusion: Satisfactory procedural outcomes and a low rate of adverse events were obtained in a complex CTO population, treated by operators with variable experience levels. Antegrade wire escalation was the preferred strategy, regardless of operator volume.

Published
2017

18. Percutaneous coronary intervention versus coronary artery bypass grafting in patients with three-vessel or left main coronary artery disease: 10-year follow-up of the multicentre randomised controlled SYNTAX trial

Author

Thuijs, Daniel J F M, primary, Kappetein, A Pieter, additional, Serruys, Patrick W, additional, Mohr, Friedrich-Wilhelm, additional, Morice, Marie-Claude, additional, Mack, Michael J, additional, Holmes, David R, additional, Curzen, Nick, additional, Davierwala, Piroze, additional, Noack, Thilo, additional, Milojevic, Milan, additional, Dawkins, Keith D, additional, da Costa, Bruno R, additional, Jüni, Peter, additional, Head, Stuart J, additional, Casselman, Filip, additional, de Bruyne, Bernard, additional, Høj Christiansen, Evald, additional, Ruiz-Nodar, Juan M., additional, Vermeersch, Paul, additional, Schultz, Werner, additional, Sabaté, Manel, additional, Guagliumi, Giulio, additional, Grubitzsch, Herko, additional, Stangl, Karl, additional, Darremont, Olivier, additional, Bentala, M., additional, den Heijer, Peter, additional, Preda, Istvan, additional, Stoler, Robert, additional, Mack, Michael J., additional, Szerafin, Tamás, additional, Buckner, John K., additional, Guber, Myles S., additional, Verberkmoes, Niels, additional, Akca, Ferdi, additional, Feldman, Ted, additional, Beyersdorf, Friedhelm, additional, Drieghe, Benny, additional, Oldroyd, Keith, additional, Berg, Geoff, additional, Jeppsson, Anders, additional, Barber, Kimberly, additional, Wolschleger, Kevin, additional, Heiser, John, additional, van der Harst, Pim, additional, Mariani, Massimo A., additional, Reichenspurner, Hermann, additional, Stark, Christoffer, additional, Laine, Mika, additional, Ho, Paul C., additional, Chen, John C., additional, Zelman, Richard, additional, Horwitz, Phillip A., additional, Bochenek, Andrzej, additional, Krauze, Agata, additional, Grothusen, Christina, additional, Dudek, Dariusz, additional, Heyrich, George, additional, Kolh, Philippe, additional, LeGrand, Victor, additional, Coelho, Pedro, additional, Ensminger, Stephan, additional, Nasseri, Boris, additional, Ingemansson, Richard, additional, Olivecrona, Goran, additional, Escaned, Javier, additional, Guera, Reddy, additional, Berti, Sergio, additional, Chieffo, Alaide, additional, Burke, Nicholas, additional, Mooney, Michael, additional, Spolaor, Alvise, additional, Hagl, Christian, additional, Näbauer, Michael, additional, Suttorp, Maarten Jan, additional, Stine, Ronald A., additional, McGarry, Thomas, additional, Lucas, Scott, additional, Endresen, Knut, additional, Taussig, Andrew, additional, Accola, Kevin, additional, Canosi, Umberto, additional, Horvath, Ivan, additional, Cannon, Louis, additional, Talbott, John D., additional, Akins, Chris W., additional, Kramer, Robert, additional, Aschermann, Michael, additional, Killinger, William, additional, Narbute, Inga, additional, Holmes, David R., additional, Burzotta, Francesco, additional, Bogers, Ad, additional, Zijlstra, Felix, additional, Eltchaninoff, Helene, additional, Berland, Jacques, additional, Stefanini, Giulio, additional, Cruz Gonzalez, Ignacio, additional, Hoppe, Uta, additional, Kiesz, Stefan, additional, Gora, Bartlomiej, additional, Ahlsson, Anders, additional, Corbascio, Matthias, additional, Bilfinger, Thomas, additional, Carrie, Didier, additional, Tchétché, Didier, additional, Hauptman, Karl-Eugen, additional, Stahle, Elisabeth, additional, James, Stefan, additional, Sandner, Sigrid, additional, Laufer, Günther, additional, Lang, Irene, additional, Witkowski, Adam, additional, Thourani, Vinod, additional, Suryapranata, Harry, additional, Redwood, Simon, additional, Knight, Charles, additional, MacCarthy, Philip, additional, de Belder, Adam, additional, Banning, Adrian, additional, and Gershlick, Anthony, additional

Published
2019
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22. Transcatheter left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation: results from the Belgian registry.

Author

UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de cardiologie, Kefer, Joelle, Aminian, Adel, Vermeersch, Paul, de Potter, Tom, Stammen, Francis, Benit, Edouard, Budts, Werner, Missault, Luc, Drieghe, Benny, Buysschaert, Ian, Cornelis, Kristoff, Herzet, Jean-Manuel, Guedes, Antoine, Debbas, Nadia, Rivero, Maximo, Lempereur, Mathieu, Lochy, Stijn, Casado-Arroyo, Ruben, Laruelle, Christophe, Debruyne, Philippe, Ledent, Thierry, UCL - SSS/IREC/MONT - Pôle Mont Godinne, UCL - (MGD) Service de cardiologie, Kefer, Joelle, Aminian, Adel, Vermeersch, Paul, de Potter, Tom, Stammen, Francis, Benit, Edouard, Budts, Werner, Missault, Luc, Drieghe, Benny, Buysschaert, Ian, Cornelis, Kristoff, Herzet, Jean-Manuel, Guedes, Antoine, Debbas, Nadia, Rivero, Maximo, Lempereur, Mathieu, Lochy, Stijn, Casado-Arroyo, Ruben, Laruelle, Christophe, Debruyne, Philippe, and Ledent, Thierry

Abstract

This study aimed to assess the safety and efficacy at midterm follow-up of left atrial appendage occlusion (LAAO) using different devices, in real life in Belgium. Between June 2009 and November 2016, 457 consecutive patients (63% male, 75±12 yrs, CHA2DS2-VASc 4±0.6, HAS-BLED 3.5±0.7) undergoing LAAO were included. Technical success was 97.1%. There were 19 periprocedural major adverse events (4.1%) including three deaths (0.6%), nine tamponades (1.9%), four major bleedings (0.8%) and two device embolisations (0.4%). Among patients successfully implanted having a complete follow-up (672 patient-years, median follow-up 370 days), the actual annual stroke rate was 1.2%, lower than the expected stroke risk of 4% (70% reduction). The observed bleeding rate was 2%, while the calculated risk was 3.7% (46% reduction). Kaplan-Meier analysis showed a similar overall survival (93±2% and 87±3% versus 91±3% and 87±4%; p=0.35) and event-free survival (92±2% and 84±3% versus 88±3% and 80±5%; p=0.17) at one and two years, for the ACP/Amulet versus the WATCHMAN groups of patients, respectively. The data from the Belgian left atrial appendage occlusion registry suggest that the procedure is effective and relatively safe in a real-world setting, using either the WATCHMAN or the ACP/Amulet device.

Published
2018

23. Transcatheter left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation: Results from the Belgian registry

Author

Kefer, Joelle, Aminian, Adel, Vermeersch, Paul, De Potter, Tom, Stammen, Francis, Benit, Edouard, Budts, Werner, Missault, Luc, Drieghe, Benny, Buysschaert, Ian, Cornelis, Kristoff, Herzet, Jean Manuel, Guédès, Antoine, Debbas, Nadia, Rivero, Maximo, Lempereur, Mathieu, Lochy, Stijn, Casado Arroyo, Ruben, Laruelle, Christophe, Debruyne, Philippe, Ledent, Thierry, Kefer, Joelle, Aminian, Adel, Vermeersch, Paul, De Potter, Tom, Stammen, Francis, Benit, Edouard, Budts, Werner, Missault, Luc, Drieghe, Benny, Buysschaert, Ian, Cornelis, Kristoff, Herzet, Jean Manuel, Guédès, Antoine, Debbas, Nadia, Rivero, Maximo, Lempereur, Mathieu, Lochy, Stijn, Casado Arroyo, Ruben, Laruelle, Christophe, Debruyne, Philippe, and Ledent, Thierry

Abstract

Aims: This study aimed to assess the safety and efficacy at midterm follow-up of left atrial appendage occlusion (LAAO) using different devices, in real life in Belgium. Methods and results: Between June 2009 and November 2016, 457 consecutive patients (63% male, 75±12 yrs, CHA2DS2-VASc 4±0.6, HAS-BLED 3.5±0.7) undergoing LAAO were included. Technical success was 97.1%. There were 19 periprocedural major adverse events (4.1%) including three deaths (0.6%), nine tamponades (1.9%), four major bleedings (0.8%) and two device embolisations (0.4%). Among patients successfully implanted having a complete follow-up (672 patient-years, median follow-up 370 days), the actual annual stroke rate was 1.2%, lower than the expected stroke risk of 4% (70% reduction). The observed bleeding rate was 2%, while the calculated risk was 3.7% (46% reduction). Kaplan- Meier analysis showed a similar overall survival (93±2% and 87±3% versus 91±3% and 87±4%; p=0.35) and event-free survival (92±2% and 84±3% versus 88±3% and 80±5%; p=0.17) at one and two years, for the ACP/Amulet versus the WATCHMAN groups of patients, respectively. Conclusions: The data from the Belgian left atrial appendage occlusion registry suggest that the procedure is effective and relatively safe in a real-world setting, using either the WATCHMAN or the ACP/Amulet device., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2018

24. The evolution of the CTO-PCI landscape in Belgium and Luxembourg: a four-year appraisal

Author

Eertmans, Ward, Kayaert, Peter, Bennett, Johan, Ungureanu, Claudiu, Bataille, Yoann, Saad, Georges, Haine, Steven, Coussement, Patrick, Pereira, Bruno, Agostoni, Pierfrancesco, Janssens, Luc, Vandeloo, Bert, Maréchal, Patrick, Cornelis, Kristoff, de Hemptinne, Quentin, Aminian, Adel, Stammen, Francis, Carlier, Stéphane, Timmermans, Patrick, Vercauteren, Steven, Sonck, Jeroen, De Vroey, Frédéric, Drieghe, Benny, McCutcheon, Keir, Scott, Benjamin, Davin, Laurent, Gafari, Chadi, and Dens, Jo

Abstract

AbstractBackgroundTo chart the evolution of the CTO-PCI landscape in Belgium and Luxembourg, the Belgian Working Group on Chronic Total Occlusions (BWGCTO) was established in 2016.MethodsBetween May 2016 and December 2019, patients undergoing a CTO-PCI treatment were prospectively and consecutively enrolled. Twenty-one centres in Belgium and one in Luxembourg participated. Individual operators had mixed levels of expertise in treating CTO lesions. Demographic, angiographic, procedural parameters and incidence of major adverse cardiac and cerebrovascular events (MACCE) were systematically registered.ResultsOver a four-year enrolment period, 1832 procedures were performed in 1733 patients achieving technical success in 1474 cases (80%), with an in-hospital MACCE rate of 2.3%. Fifty-nine (3%) cases were re-attempt procedures of which 41 (69%) were successful. High-volume centres treated more complex lesions (mean J-CTO score: 2.15 ± 1.21) as compared to intermediate (mean J-CTO score: 1.72 ± 1.23; p < 0.001) and low-volume centres (mean J-CTO score: 0.99 ± 1.21; p = 0.002). Despite this, success rates did not differ between centres (p = 0.461). Overall success rates did not differ over time (p = 0.810). High-volume centres progressively tackled more complex CTOs while keeping success rates stable. In all centres, the most applied strategy was antegrade wire escalation (83%). High-volume centres more often successfully applied antegrade dissection and re-entry and retrograde techniques in lesions with higher complexity.ConclusionWith variable experience levels, operators treated CTOs with high success and relatively few complications. Although AWE remains the most used technique, it is paramount for operators to be skilled in all contemporary techniques in order to be successful in more complex CTOs.

Published
2021
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26. Transcatheter left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation: results from the Belgian registry

Author

Kefer, Joelle, primary, Aminian, Adel, additional, Vermeersch, Paul, additional, de Potter, Tom, additional, Stammen, Francis, additional, Benit, Edouard, additional, Budts, Werner, additional, Missault, Luc, additional, Drieghe, Benny, additional, Buysschaert, Ian, additional, Cornelis, Kristoff, additional, Herzet, Jean-Manuel, additional, Guedes, Antoine, additional, Debbas, Nadia, additional, Rivero, Maximo, additional, Lempereur, Mathieu, additional, Lochy, Stijn, additional, Casado-Arroyo, Ruben, additional, Laruelle, Christophe, additional, Debruyne, Philippe, additional, and Ledent, Thierry, additional

Published
2018
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28. Screening for pulmonary arterial hypertension in an unselected prospective systemic sclerosis cohort

Author

Vandecasteele, Els, primary, Drieghe, Benny, additional, Melsens, Karin, additional, Thevissen, Kristof, additional, De Pauw, Michel, additional, Deschepper, Ellen, additional, Decuman, Saskia, additional, Bonroy, Carolien, additional, Piette, Yves, additional, De Keyser, Filip, additional, Brusselle, Guy, additional, and Smith, Vanessa, additional

Published
2017
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29. 89-06: Assessment of vectorcardiographic parameters of the paced QRS complex as prediction of acute hemodynamic response in CRT patients

Author

De Pooter, Jan, primary, El Haddad, Milad, additional, De Buyzere, Marc, additional, Timmers, Liesbeth, additional, Drieghe, Benny, additional, Timmermans, Frank, additional, Rinaldi, Aldo, additional, Stegemann, Berthold, additional, Francis, Darrel, additional, Vanderheyden, Marc, additional, Sokal, Adam, additional, Sterlinski, Maciej, additional, Alfonso Aranda, Hernandez, additional, Cornelussen, Richard, additional, Jordaens, Luc, additional, Stroobandt, Roland X., additional, and Van Heuverswyn, Frederic, additional

Published
2016
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31. Assessing the landscape of percutaneous coronary chronic total occlusion treatment in Belgium and Luxembourg: the Belgian Working Group on Chronic Total Occlusions (BWGCTO) registry

Author

Maeremans, Joren, Kayaert, Peter, Bataille, Yoann, Bennett, Johan, Ungureanu, Claudiu, Haine, Steven, Vandendriessche, Tom, Sonck, Jeroen, Scott, Benjamin, Coussement, Patrick, Dendooven, Daniël, Pereira, Bruno, Frambach, Peter, Janssens, Luc, Debruyne, Philippe, Van Mieghem, Carlos, Barbato, Emanuele, Cornelis, Kristoff, Stammen, Francis, De Vroey, Frederic, Vercauteren, Steven, Drieghe, Benny, Aminian, Adel, Debrauwere, Jan, Carlier, Stéphane, Coosemans, Mark, Van Reet, Bert, Vandergoten, Peter, and Dens, Jo Andre

Abstract

AbstractBackground:Important developments in materials, devices, and techniques have improved outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI), and resulted in a growing interest in CTO-PCI. The Belgian Working Group on Chronic Total Occlusions (BWGCTO) working group aims to assess the evolution within the CTO-PCI landscape over the next years.Methods:From May 2016 onwards, patients undergoing CTO-PCI were included in the BWGCTO registry by 15 centres in Belgium and Luxemburg. Baseline, angiographic, and procedural data were collected. Here, we report on the one-year in-hospital outcomes.Results:Over the course of one year, 411 procedures in 388 patients were included with a mean age of 64 ± 11 years. The majority were male (81%). Relatively complex CTOs were treated (Japanese CTO score =2.2 ± 1.2) with a high procedure success rate (82%). Patient- and lesion-wise success rates were 83 and 85%, respectively. Major adverse in-hospital events were acceptably low (3.4%). Antegrade wire escalation technique was applied most frequently (82%). On the other hand, antegrade dissection and re-entry and retrograde strategies were more frequently applied in higher volume centres and successful for lesions with higher complexity.Conclusion:Satisfactory procedural outcomes and a low rate of adverse events were obtained in a complex CTO population, treated by operators with variable experience levels. Antegrade wire escalation was the preferred strategy, regardless of operator volume.

Published
2018
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34. Spontaneous carotid artery dissection: a rare cause of cerebrovascular accident

Author

Simoens, Jan, François, Olivier, and Drieghe, Benny

Abstract

We present the case of a young woman who developed a cerebrovascular accident due to a spontaneous internal carotid artery dissection. We stress the importance of clinical clues to diagnosis: ipsilateral facial pain and a partial Horner’s syndrome are the most frequent clinical manifestations. Compared to patients with atherosclerotic cerebrovascular disease, these patient are younger and typically do not have the classical cardiovascular risk factors. The diagnosis should be confirmed with duplex ultrasound and magnetic resonance imaging or computed tomographic angiography.In many cases, optimal therapy consists of ‘watchful waiting’ and prompt initiation of oral anticoagulants (during 3 to 6 months) and aspirin or clopidogrel in case of late presentation without ischaemic symptoms. Endovascular or surgical treatment is rarely needed.The overall prognosis is more benign compared to atherosclerotic cerebrovascular disease, although a somewhat elevated risk for recurrent dissection is observed.

Published
2007
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36. iFR/FFR/IVUS Discordance and Clinical Implications: Results From the Prospective Left Main Physiology Registry.

Author

Kayaert P, Coeman M, Ghafari C, Drieghe B, Gheeraert P, Bennett J, McCutcheon K, Ungureanu C, Vandeloo B, Floré V, Hermans K, Dens J, Saad G, Janssens L, Xaplanteris P, Bataille Y, Semeraro O, Kefer J, Gevaert S, De Pauw M, Carlier S, Claeys MJ, and Haine S

Subjects
Humans, Prospective Studies, Clinical Decision-Making, Constriction, Pathologic, Registries, Fractional Flow Reserve, Myocardial
Abstract

Objectives: This study aimed to assess discordance between results of instantaneous wave-free ratio (iFR), fractional flow reserve (FFR), and intravascular ultrasound (IVUS) in intermediate left main coronary (LM) lesions, and its impact on clinical decision making and outcome., Methods: We enrolled 250 patients with a 40%-80% LM stenosis in a prospective, multicenter registry. These patients underwent both iFR and FFR measurements. Of these, 86 underwent IVUS and assessment of the minimal lumen area (MLA), with a 6 mm2 cutoff for significance., Results: Isolated LM disease was recognized in 95 patients (38.0%), while 155 patients (62.0%) had both LM disease and downstream disease. In 53.2% of iFR+ and 56.7% of FFR+ LM lesions, the measurement was positive in only one daughter vessel. iFR/FFR discordance occurred in 25.0% of patients with isolated LM disease and 36.2% of patients with concomitant downstream disease (P=.049). In patients with isolated LM disease, discordance was significantly more common in the left anterior descending artery and younger age was an independent predictor of iFR-/FFR+ discordance. iFR/MLA and FFR/MLA discordance occurred in 37.0% and 29.4%, respectively. Within 1 year of follow-up, major cardiac adverse events (MACE) occurred in 8.5% and 9.7% (P=.763) of patients whose LM lesion was deferred or revascularized, respectively. Discordance was not an independent predictor of MACE., Conclusions: Current methods of estimating LM lesion significance often yield discrepant findings, complicating therapeutic decision-making.

Published
2023
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37. Clinical validation of a 13-lead electrocardiogram derived from a self-applicable 3-lead recording for diagnosis of myocardial supply ischaemia and common non-ischaemic electrocardiogram abnormalities at rest.

Author

Van Heuverswyn F, De Schepper C, De Buyzere M, Coeman M, De Pooter J, Drieghe B, Kayaert P, Timmers L, Gevaert S, Calle S, Kamoen V, Demolder A, El Haddad M, and Gheeraert P

Abstract

Aims: In this study, we compare the diagnostic accuracy of a standard 12-lead electrocardiogram (ECG) with a novel 13-lead ECG derived from a self-applicable 3-lead ECG recorded with the right exploratory left foot (RELF) device. The 13th lead is a novel age and sex orthonormalized computed ST (ASO-ST) lead to increase the sensitivity for detecting ischaemia during acute coronary artery occlusion., Methods and Results: A database of simultaneously recorded 12-lead ECGs and RELF recordings from 110 patients undergoing coronary angioplasty and 30 healthy subjects was used. Five cardiologists scored the learning data set and five other cardiologists scored the validation data set. In addition, the presence of non-ischaemic ECG abnormalities was compared. The accuracy for detection of myocardial supply ischaemia with the derived 12 leads was comparable with that of the standard 12-lead ECG ( P = 0.126). By adding the ASO-ST lead, the accuracy increased to 77.4% [95% confidence interval (CI): 72.4-82.3; P < 0.001], which was attributed to a higher sensitivity of 81.9% (95% CI: 74.8-89.1) for the RELF 13-lead ECG compared with a sensitivity of 76.8% (95% CI: 71.9-81.7; P < 0.001) for the 12-lead ECG. There was no significant difference in the diagnosis of non-ischaemic ECG abnormalities, except for Q-waves that were more frequently detected on the standard ECG compared with the derived ECG (25.9 vs. 13.8%; P < 0.001)., Conclusion: A self-applicable and easy-to-use 3-lead RELF device can compute a 12-lead ECG plus an ischaemia-specific 13th lead that is, compared with the standard 12-lead ECG, more accurate for the visual diagnosis of myocardial supply ischaemia by cardiologists., Competing Interests: Conflict of interest: P.G. and M.E.H. declare the patents EP3003140A1 (European Patent Office), CA2912476C (Canada), WO2014187998A1 (WIPO [PCT]), US9867577B2 (USA). All other authors declare no competing interests., (© The Author(s) 2022. Published by Oxford University Press on behalf of the European Society of Cardiology.)

Published
2022
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39. Renal V-stenting.

Author

Vercauteren S, Drieghe B, and De Bruyne B

Subjects
Aged, 80 and over, Angiography methods, Catheterization instrumentation, Catheterization methods, Humans, Hypertension, Renovascular etiology, Male, Renal Artery Obstruction complications, Renal Artery Obstruction pathology, Renal Artery pathology, Renal Artery Obstruction therapy, Stents
Published
2007

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