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1. Mortality, perioperative complications and surgical timelines in hip fracture patients: Comparison of the Spanish with the non-Spanish Cohort of the HIP ATTACK-1 trial

Author

Veevaete, Laurent, Waroux, Bernard le Polain de, Lavand'homme, Patricia, Cornu, Olivier, Tribak, Karim, Yombi, Jean C, Touil, Nassim, Bhutia, Jigme T, Clinckaert, Carol, Clippeleir, Dirk De, Reul, Maike, Patel, Ameen, Tandon, Vikas, Gauthier, Leslie P, Avram, Victoria R.A., Winemaker, Mitchell, de Beer, Justin, Simpson, Diane L, Worster, Andrew, Alvarado, Kim A, Gregus, Krysten K, Lawrence, Kelly H, Leong, Darryl P, Joseph, Philip G, Magloire, Patrick, Deheshi, Benjamin, Bisland, Stuart, Wood, Thomas J, Tushinski, Daniel M., Wilson, David A.J., Haider, Shariq, Bali, Kamal, Kearon, Clive, Manach, Yannick Le, Adili, Anthony, Tiboni, Maria E, Neary, John D, Cowan, David D, Khanna, Vickas, Zaki, Amna, Farrell, Janet C, MacDonald, Anne Marie, Conen, David, Wong, Steven C.W., Karbassi, Arsha, Wright, Douglas S, Shanthanna, Harsha, Coughlin, Ryan, Khan, Moin, Wikkerink, Spencer, Quraishi, Faraaz A, Lawendy, Abdel-Rahman, Kishta, Waleed, Schemitsch, Emil, Carey, Timothy, Macleod, Mark D, Sanders, David W, Vasarhelyi, Edward, Bartley, Debra, Dresser, George K, Tieszer, Christina, Jenkinson, Richard J, Shadowitz, Steven, Lee, Jacques S, Choi, Stephen, Kreder, Hans J, Nousiainen, Markku, Kunz, Monica R, Tuazon, Ravianne, Shrikumar, Mopina, Ravi, Bheeshma, Wasserstein, David, Stephen, David J.G., Nam, Diane, Henry, Patrick D.G., Wood, Gavin C.A., Mann, Stephen M., Jaeger, Melanie T., Sivilotti, Marco L.A., Smith, Christopher A., Frank, Christopher C., Grant, Heather, Ploeg, Leone, Yach, Jeff D., Harrison, Mark M., Campbell, Aaron R., Bicknell, Ryan T., Bardana, Davide D., Feibel, Robert J., McIlquham, Katie, Gallant, Catherine, Halman, Samantha, Thiruganasambandamoorth, Venkatesh, Ruggiero, Sara, Hadden, William J., Chen, Brian P.J., Coupal, Stephanie A., McMahon, Stephen J., McLean, Lisa M., Shirali, Hemant R., Haider, Syed Y., Smith, Crystal A., Watts, Evan, Santone, David J., Koo, Kevin, Yee, Allan J., Oyenubi, Ademilola N., Nauth, Aaron, Schemitsch, Emil H., Daniels, Timothy R., Ward, Sarah E., Hall, Jeremy A., Ahn, Henry, Whelan, Daniel B., Atrey, Amit, Khoshbin, Amir, Puskas, David, Droll, Kurt, Cullinan, Claude, Payendeh, Jubin, Lefrancois, Tina, Mozzon, Lise, Marion, Travis, Jacka, Michael J., Greene, James, Menon, Matthew, Stiegelmahr, Robert, Dillane, Derek, Irwin, Marleen, Beaupre, Lauren, Coles, Chad P., Trask, Kelly, MacDonald, Shelley, Trenholm, J.A.I., Oxner, William, Richardson, C.G., Dehghan, Niloofar, Sadoughi, Mehdi, Sharma, Achal, White, Neil J., Olivieri, Loretta, Hunt, Stephen B., Turgeon, Thomas R., Bohm, Eric R., Tran, Sarah, Giilck, Stephen M., Hupel, Tom, Guy, Pierre, O'Brien, Peter J., Duncan, Andrew W., Crawford, Gordon A., hou, Junlin, Zhao, Yanrui, Liu, Yang, Shan, Lei, Wu, Anshi, Muñoz, Juan M., Chaudier, Philippe, Douplat, Marion, Fessy, Michel Henri, Piriou, Vincent, Louboutin, Lucie, David, Jean Stephane, Friggeri, Arnaud, Beroud, Sebastien, Fayet, Jean Marie, Landais, Paul, Leung, Frankie Ka Li, Fang, Christian Xinshuo, Yee, Dennis King Hang, Sancheti, Parag K., Pradhan, Chetan V., Patil, Atul A., Puram, Chetan P., Borate, Madhav P., Kudrimoti, Kiran B., Adhye, Bharati A., Dongre, Himanshu V., John, Bobby, Abraham, Valsamma, Pandey, Ritesh A., Rajkumar, Arti, George, Preetha E., Sigamani, Alen, Stephen, Manesh, Chandran, Nitheesh, Ashraf, Mohammed, Georgekutty, A.M., Sulthan, Ahamad S., Adinarayanan, S., Sharma, Deep, Barnawal, Satish P., Swaminathan, Srinivasan, Bidkar, Prasanna U., Mishra, Sandeep K., Menon, Jagdish, M, Niranjan, Zk, Varghese, Hiremath, Santosh A., Nc, Madhusudhan, Jawali, Abhijit, Gnanadurai, Kingsly R., George, Carolin E., Maddipati, Atarao, Kp, Mary, Sharma, Vijay, Farooque, Kamran, Malhotra, Rajesh, Mittal, Samarth, Sawhney, Chavi, Gupta, Babita, Mathur, Purva, Gamangati, Shivanand, Tripathy, Vijaylaxmi, Menon, Prem H., Dhillon, Mandeep S., Chouhan, Devendra K., Patil, Sharanu, Narayan, Ravi, Lal, Purushotham, Bilchod, Prashanth N., Singh, Surya U., Gattu, Uttam V., Dashputra, Ravi P., Rahate, Prashant V., Turiel, Maurizio, Blasio, Giuseppe De, Accetta, Riccardo, Perazzo, Paolo, Stella, Daniele, Bonadies, Marika, Colombo, Chiara, Fozzato, Stefania, Pino, Fabio, Morelli, Ilaria, Colnaghi, Eleonora, Salini, Vincenzo, Denaro, Giuseppe, Beretta, Luigi, Placella, Giacomo, Giardina, Giuseppe, Binda, Mirko, Marcato, Anna, Guzzetti, Luca, Piccirillo, Fabio, Cecconi, Maurizio, Khor, H.M., Lai, Hou Yee, Kumar, C.S., Chee, K.H., Loh, P.S., Tan, Kit Mun, Singh, Simmrat, Foo, Li Lian, Prakasam, Komella, Chaw, Sook Hui, Lee, Meng-Li, Ngim, Joanne H.L., Boon, Huck Wee, Chin, Im Im, Kleinlugtenbelt, Ydo V., Landman, Ellie B.M., Flikweert, Elvira R., Roerdink, Herbert W., Brokelman, Roy B.G., Elskamp-Meijerman, Hannie F., Horst, Maarten R., Cobben, Jan-Hein M.G., Umer, Masood, Begum, Dilshad, Anjum, Anila, Hashmi, Pervaiz M., Ahmed, Tashfeen, Rashid, Haroon U., Khattak, Mujahid J., Rashid, Rizwan H., Lakdawala, Riaz H., Noordin, Shahryar, Juman, Naveed M., Khan, Robyna I., Riaz, Muhammad M., Bokhari, Syedah S., Almas, Ayesha, Wahab, Hussain, Ali, Arif, Khan, Hammad N., Khan, Eraj K., Nur, Aamer Nabi, Janjua, Kholood A., Orakzai, Sajjad H., Khan, Abdus S., Mustafa, Khawaja J., Sohail, Mian A., Umar, Muhammad, Khan, Siddra A., Ashraf, Muhammad, Khan, Muhammad K., Shiraz, Muhammad, Furgan, Ahmad, Ślęczka, Paweł, Dąbek, Piotr, Kumoń, Adam, Satora, Wojciech, Ambroży, Wojciech, Święch, Mariusz, Rycombel, Jacek, Grzelak, Adrian, Nowak- Kózka, Ilona, Gucwa, Jaroslaw, Machala, Waldemar, Ramokgopa, Mmampapatla T., Firth, Gregory B., Karera, Mwalimu, Fourtounas, Maria, Singh, Virsen, Biscardi, Anna, Iqbal, Muhammad N., Campbell, Ryan J., Maluleke, Matimba L., Moller, Carien, Nhlapo, Lerato, Maqungo, Sithombo, Flint, Margot, Nejthardt, Marcin B., Chetty, Sean, Naidoo, Rubendren, Guerra-Farfan, Ernesto, Tomas-Hernandez, Jordi, Garcia-Sanchez, Yaiza, Clua, Miriam Garrido, Molero-Garcia, Vicente, Minguell-Monyart, Joan, Teixidor-Serra, Jordi, Villar-Casares, Maria del Mar, Marsa, Jordi Selga, Porcel-Vazquez, Juan A., Andres-Peiro, Jose-Vicente, Aguilar, Marc, Mestre-Torres, Jaume, Colomina, Maria J., Guilabert, Patricia, Gozalo, M Luisa Paños, Abarca, Luis, Martin, Nuria, Usua, Gemma, Martinez-Ripol, Pedro, Posada, M.A. Gonzalez, Lalueza-Broto, Pilar, Sanchez-Raya, Judith, Camarena, Jorge Nuñez, Fraguas-Castany, Antoni, Balaguer-Castro, Mariano, Torner, Pere, Jornet-Gibert, Montsant, Serrano-Sanz, Jorge, Cámara-Cabrera, Jaume, Salomó-Domènech, Mònica, Yela-Verdú, Christian, Peig-Font, Anna, Ricol, Laura, Carreras-Castañer, Anna, Martínez-Sañudo, Luis, Herranz, Susana, Feijoo-Massó, Carlos, Sianes-Gallén, Mònica, Castillόn, Pablo, Bernaus, Martí, Quintas, Saioa, Gόmez, Olga, Salvador, Jordi, Abarca, Javier, Estrada, Cristina, Novellas, Marga, Torra, Mercè, Dealbert, Alfred, Macho, Oscar, Ivanov, Alexia, Valldosera, Esther, Arroyo, Marta, Pey, Borja, Yuste, Antoni, Mateo, Llorenç, Caso, Julio De, Anaya, Rafael, Higa-Sansone, J.L., Millan, Angelica, Baños, Victoria, Herrera-Mateo, Sergio, Aguado, Hector, Martinez-Municio, Gonzalo, León, Ricardo, Santiago-Maniega, Silvia, Zabalza, Ana, Labrador, Gregorio, Guerado, Enrique, Ramirez-Roldan, Alicia, Cruz, Encarnacion, Cano, Juan R, Bogallo, Jose M, Sangasoongsong, Paphon, Kulachote, Noratep, Sirisreetreerux, Norachart, Pengrung, Nachapan, Chalacheewa, Theerawat, Arnuntasupakul, Vanlapa, Yingchoncharoen, Teerapat, Naratreekoon, Bundit, Kadry, Miriam A, Thayaparan, Surendini, Abdlaziz, Ihab, Aframian, Arash, Imbuldeniya, Arjuna, Movahedi, Roya, Omran, Sherif, Vizcaychipi, Marcela P, Correia, Patricia, Patil, Shashank, Haire, Kevin, Mayor, Amy S.E., Dillingham, Sally, Nicholson, Laura, Elnaggar, Mohamed, John, Joby, Nanjayan, Shashi K, Parker, Martyn J, O'Sullivan, Susan, Marmor, Meir T, Matityahu, Amir, McClellan, Robert T, Comstock, Curt, Ding, Anthony, Toogood, Paul, Slobogean, Gerard, Joseph, Katherine, O'Toole, Robert, Sciadini, Marcus, Ryan, Scott P, Clark, Molly E, Cassidy, Charles, Balonov, Konstantin, Bergese, Sergio D, Phieffer, Laura S, Gonzalez-Zacarias, Alicia A, Marcantonio, Andrew J, Borges, Flavia K., Bhandari, Mohit, Nuñez, Jorge H., Castillon, Pablo, De Caso Rodriguez, Julio, Aguado, Hector J., Popova, Ekaterine, Tonelli, Ana Claudia, Balasubramanian, Kumar, Vincent, Jessica, Harvey, Valerie, Kocaqi, Etri, and Devereaux, P.J.

Published
2024
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2. Apixaban Concentrations with Lower than Recommended Dosing in Older Adults with Atrial Fibrillation

Author

Sukumar, Smrithi, Gulilat, Markus, Linton, Bradley, Gryn, Steven E, Dresser, George K, Alfonsi, Jeffrey E, Schwarz, Ute I, Kim, Richard B, and Schwartz, Janice B

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Clinical Research, Heart Disease, Clinical Trials and Supportive Activities, Aging, Cardiovascular, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Aged, Aged, 80 and over, Anticoagulants, Atrial Fibrillation, Dose-Response Relationship, Drug, Female, Humans, Male, Pyrazoles, Pyridones, apixaban, direct-acting oral anticoagulant, nonvalvular atrial fibrillation, dosing accuracy, Medical and Health Sciences, Geriatrics, Biomedical and clinical sciences, Health sciences, Psychology
Abstract

ObjectivesLower than recommended doses of direct-acting oral anticoagulants are often prescribed to older adults with nonvalvular atrial fibrillation (NVAF). Our goal was to determine the consequences of lower than recommended dosing on plasma apixaban concentrations during the clinical care of older adults with NVAF.DesignConvenience sample of patients receiving anticoagulation during 2017.SettingAcademic medical center.ParticipantsStable adults older than 65 years with NVAF receiving apixaban on a chronic basis.MeasurementsPatient age, weight, creatinine, co-medications, and apixaban concentrations.ResultsA total of 110 older adults with NVAF (mean age = 80.4 y; range = 66-100 y with 45% women) were studied. Overall, 48 patients received recommended dosing of 5 mg twice/day, and 42 received lower than recommended dosing. One patient in each category had concentrations below the expected 5% to 95% range at time of peak concentrations. Differences in proportion of apixaban concentrations within or outside expected ranges were not significant between patients receiving lower than recommended doses and those dosed as recommended at 5 mg twice/day (P = .35). However, in patients dosed as recommended with 5 mg twice/day, four had concentrations above the 5% to 95% range for peak levels expected at 3 to 4 hours after dosing; in two, this occurred around the midpoint of the dosing interval. Twenty patients received 2.5 mg twice/day as recommended. One-third had apixaban concentrations higher than expected peak concentrations compared with the clinical trials, and more than two-thirds had levels above the reported median for peak concentrations.ConclusionsApixaban concentrations in older adults with NVAF seen clinically were higher than expected based on clinical trial data. The findings raise questions about the optimal dosing of apixaban in older adults with NVAF encountered outside of clinical trials and suggest a role for the monitoring of apixaban concentrations during care of patients that differ from those in randomized trials or when considering dosing outside of published guidelines. J Am Geriatr Soc 67:1902-1906, 2019.

Published
2019

3. Hypertension Canada’s 2020 Comprehensive Guidelines for the Prevention, Diagnosis, Risk Assessment, and Treatment of Hypertension in Adults and Children

Author

Rabi, Doreen M., McBrien, Kerry A., Sapir-Pichhadze, Ruth, Nakhla, Meranda, Ahmed, Sofia B., Dumanski, Sandra M., Butalia, Sonia, Leung, Alexander A., Harris, Kevin C., Cloutier, Lyne, Zarnke, Kelly B., Ruzicka, Marcel, Hiremath, Swapnil, Feldman, Ross D., Tobe, Sheldon W., Campbell, Tavis S., Bacon, Simon L., Nerenberg, Kara A., Dresser, George K., Fournier, Anne, Burgess, Ellen, Lindsay, Patrice, Rabkin, Simon W., Prebtani, Ally P.H., Grover, Steven, Honos, George, Alfonsi, Jeffrey E., Arcand, JoAnne, Audibert, François, Benoit, Geneviève, Bittman, Jesse, Bolli, Peter, Côté, Anne-Marie, Dionne, Janis, Don-Wauchope, Andrew, Edwards, Cedric, Firoz, Tabassum, Gabor, Jonathan Y., Gilbert, Richard E., Grégoire, Jean C., Gryn, Steven E., Gupta, Milan, Hannah-Shmouni, Fady, Hegele, Robert A., Herman, Robert J., Hill, Michael D., Howlett, Jonathan G., Hundemer, Gregory L., Jones, Charlotte, Kaczorowski, Janusz, Khan, Nadia A., Kuyper, Laura M., Lamarre-Cliche, Maxime, Lavoie, Kim L., Leiter, Lawrence A., Lewanczuk, Richard, Logan, Alexander G., Magee, Laura A., Mangat, Birinder K., McFarlane, Philip A., McLean, Donna, Michaud, Andre, Milot, Alain, Moe, Gordon W., Penner, S. Brian, Pipe, Andrew, Poppe, Alexandre Y., Rey, Evelyne, Roerecke, Michael, Schiffrin, Ernesto L., Selby, Peter, Sharma, Mike, Shoamanesh, Ashkan, Sivapalan, Praveena, Townsend, Raymond R., Tran, Karen, Trudeau, Luc, Tsuyuki, Ross T., Vallée, Michel, Woo, Vincent, Bell, Alan D., and Daskalopoulou, Stella S.

Published
2020
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5. Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children

Author

Nerenberg, Kara A., Zarnke, Kelly B., Leung, Alexander A., Dasgupta, Kaberi, Butalia, Sonia, McBrien, Kerry, Harris, Kevin C., Nakhla, Meranda, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, Tremblay, Guy, McLean, Donna, Padwal, Raj S., Tran, Karen C., Grover, Steven, Rabkin, Simon W., Moe, Gordon W., Howlett, Jonathan G., Lindsay, Patrice, Hill, Michael D., Sharma, Mike, Field, Thalia, Wein, Theodore H., Shoamanesh, Ashkan, Dresser, George K., Hamet, Pavel, Herman, Robert J., Burgess, Ellen, Gryn, Steven E., Grégoire, Jean C., Lewanczuk, Richard, Poirier, Luc, Campbell, Tavis S., Feldman, Ross D., Lavoie, Kim L., Tsuyuki, Ross T., Honos, George, Prebtani, Ally P.H., Kline, Gregory, Schiffrin, Ernesto L., Don-Wauchope, Andrew, Tobe, Sheldon W., Gilbert, Richard E., Leiter, Lawrence A., Jones, Charlotte, Woo, Vincent, Hegele, Robert A., Selby, Peter, Pipe, Andrew, McFarlane, Philip A., Oh, Paul, Gupta, Milan, Bacon, Simon L., Kaczorowski, Janusz, Trudeau, Luc, Campbell, Norman R.C., Hiremath, Swapnil, Roerecke, Michael, Arcand, Joanne, Ruzicka, Marcel, Prasad, G.V. Ramesh, Vallée, Michel, Edwards, Cedric, Sivapalan, Praveena, Penner, S. Brian, Fournier, Anne, Benoit, Geneviève, Feber, Janusz, Dionne, Janis, Magee, Laura A., Logan, Alexander G., Côté, Anne-Marie, Rey, Evelyne, Firoz, Tabassum, Kuyper, Laura M., Gabor, Jonathan Y., Townsend, Raymond R., Rabi, Doreen M., and Daskalopoulou, Stella S.

Published
2018
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7. Hypertension Canada's 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults

Author

Leung, Alexander A., Daskalopoulou, Stella S., Dasgupta, Kaberi, McBrien, Kerry, Butalia, Sonia, Zarnke, Kelly B., Nerenberg, Kara, Harris, Kevin C., Nakhla, Meranda, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, Tremblay, Guy, McLean, Donna, Tobe, Sheldon W., Ruzicka, Marcel, Burns, Kevin D., Vallée, Michel, Prasad, G.V. Ramesh, Gryn, Steven E., Feldman, Ross D., Selby, Peter, Pipe, Andrew, Schiffrin, Ernesto L., McFarlane, Philip A., Oh, Paul, Hegele, Robert A., Khara, Milan, Wilson, Thomas W., Penner, S. Brian, Burgess, Ellen, Sivapalan, Praveena, Herman, Robert J., Bacon, Simon L., Rabkin, Simon W., Gilbert, Richard E., Campbell, Tavis S., Grover, Steven, Honos, George, Lindsay, Patrice, Hill, Michael D., Coutts, Shelagh B., Gubitz, Gord, Campbell, Norman R.C., Moe, Gordon W., Howlett, Jonathan G., Boulanger, Jean-Martin, Prebtani, Ally, Kline, Gregory, Leiter, Lawrence A., Jones, Charlotte, Côté, Anne-Marie, Woo, Vincent, Kaczorowski, Janusz, Trudeau, Luc, Tsuyuki, Ross T., Hiremath, Swapnil, Drouin, Denis, Lavoie, Kim L., Hamet, Pavel, Grégoire, Jean C., Lewanczuk, Richard, Dresser, George K., Sharma, Mukul, Reid, Debra, Lear, Scott A., Moullec, Gregory, Gupta, Milan, Magee, Laura A., Logan, Alexander G., Dionne, Janis, Fournier, Anne, Benoit, Geneviève, Feber, Janusz, Poirier, Luc, Padwal, Raj S., and Rabi, Doreen M.

Published
2017
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9. Hypertension Canada's 2016 Canadian Hypertension Education Program Guidelines for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension

Author

Leung, Alexander A., Nerenberg, Kara, Daskalopoulou, Stella S., McBrien, Kerry, Zarnke, Kelly B., Dasgupta, Kaberi, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, Tremblay, Guy, McLean, Donna, Tobe, Sheldon W., Ruzicka, Marcel, Burns, Kevin D., Vallée, Michel, Prasad, G.V. Ramesh, Lebel, Marcel, Feldman, Ross D., Selby, Peter, Pipe, Andrew, Schiffrin, Ernesto L., McFarlane, Philip A., Oh, Paul, Hegele, Robert A., Khara, Milan, Wilson, Thomas W., Penner, S. Brian, Burgess, Ellen, Herman, Robert J., Bacon, Simon L., Rabkin, Simon W., Gilbert, Richard E., Campbell, Tavis S., Grover, Steven, Honos, George, Lindsay, Patrice, Hill, Michael D., Coutts, Shelagh B., Gubitz, Gord, Campbell, Norman R.C., Moe, Gordon W., Howlett, Jonathan G., Boulanger, Jean-Martin, Prebtani, Ally, Larochelle, Pierre, Leiter, Lawrence A., Jones, Charlotte, Ogilvie, Richard I., Woo, Vincent, Kaczorowski, Janusz, Trudeau, Luc, Petrella, Robert J., Hiremath, Swapnil, Drouin, Denis, Lavoie, Kim L., Hamet, Pavel, Fodor, George, Grégoire, Jean C., Lewanczuk, Richard, Dresser, George K., Sharma, Mukul, Reid, Debra, Lear, Scott A., Moullec, Gregory, Gupta, Milan, Magee, Laura A., Logan, Alexander G., Harris, Kevin C., Dionne, Janis, Fournier, Anne, Benoit, Geneviève, Feber, Janusz, Poirier, Luc, Padwal, Raj S., and Rabi, Doreen M.

Published
2016
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10. The 2015 Canadian Hypertension Education Program Recommendations for Blood Pressure Measurement, Diagnosis, Assessment of Risk, Prevention, and Treatment of Hypertension

Author

Daskalopoulou, Stella S., Rabi, Doreen M., Zarnke, Kelly B., Dasgupta, Kaberi, Nerenberg, Kara, Cloutier, Lyne, Gelfer, Mark, Lamarre-Cliche, Maxime, Milot, Alain, Bolli, Peter, McKay, Donald W., Tremblay, Guy, McLean, Donna, Tobe, Sheldon W., Ruzicka, Marcel, Burns, Kevin D., Vallée, Michel, Ramesh Prasad, G.V., Lebel, Marcel, Feldman, Ross D., Selby, Peter, Pipe, Andrew, Schiffrin, Ernesto L., McFarlane, Philip A., Oh, Paul, Hegele, Robert A., Khara, Milan, Wilson, Thomas W., Brian Penner, S., Burgess, Ellen, Herman, Robert J., Bacon, Simon L., Rabkin, Simon W., Gilbert, Richard E., Campbell, Tavis S., Grover, Steven, Honos, George, Lindsay, Patrice, Hill, Michael D., Coutts, Shelagh B., Gubitz, Gord, Campbell, Norman R.C., Moe, Gordon W., Howlett, Jonathan G., Boulanger, Jean-Martin, Prebtani, Ally, Larochelle, Pierre, Leiter, Lawrence A., Jones, Charlotte, Ogilvie, Richard I., Woo, Vincent, Kaczorowski, Janusz, Trudeau, Luc, Petrella, Robert J., Hiremath, Swapnil, Stone, James A., Drouin, Denis, Lavoie, Kim L., Hamet, Pavel, Fodor, George, Grégoire, Jean C., Fournier, Anne, Lewanczuk, Richard, Dresser, George K., Sharma, Mukul, Reid, Debra, Benoit, Geneviève, Feber, Janusz, Harris, Kevin C., Poirier, Luc, and Padwal, Raj S.

Published
2015
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14. The 2011 Canadian Hypertension Education Program Recommendations for the Management of Hypertension: Blood Pressure Measurement, Diagnosis, Assessment of Risk, and Therapy

Author

Rabi, Doreen M., Daskalopoulou, Stella S., Padwal, Raj S., Khan, Nadia A., Grover, Steven A., Hackam, Daniel G., Myers, Martin G., McKay, Donald W., Quinn, Robert R., Hemmelgarn, Brenda R., Cloutier, Lyne, Bolli, Peter, Hill, Michael D., Wilson, Thomas, Penner, Brian, Burgess, Ellen, Lamarre-Cliché, Maxime, McLean, Donna, Schiffrin, Ernesto L., Honos, George, Mann, Karen, Tremblay, Guy, Milot, Alain, Chockalingam, Arun, Rabkin, Simon W., Dawes, Martin, Touyz, Rhian M., Burns, Kevin D., Ruzicka, Marcel, Campbell, Norman R.C., Vallée, Michel, Prasad, G.V. Ramesh, Lebel, Marcel, Campbell, Tavis S., Lindsay, M. Patrice, Herman, Robert J., Larochelle, Pierre, Feldman, Ross D., Arnold, J. Malcolm O., Moe, Gordon W., Howlett, Jonathan G., Trudeau, Luc, Bacon, Simon L., Petrella, Robert J., Lewanczuk, Richard, Stone, James A., Drouin, Denis, Boulanger, Jean-Martin, Sharma, Mukul, Hamet, Pavel, Fodor, George, Dresser, George K., Carruthers, S. George, Pylypchuk, George, Gilbert, Richard E., Leiter, Lawrence A., Jones, Charlotte, Ogilvie, Richard I., Woo, Vincent, McFarlane, Philip A., Hegele, Robert A., Poirier, Luc, and Tobe, Sheldon W.

Published
2011
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16. The 2010 Canadian Hypertension Education Program recommendations for the management of hypertension: Part 2 – therapy

Author

Hackam, Daniel G., Khan, Nadia A., Hemmelgarn, Brenda R., Rabkin, Simon W., Touyz, Rhian M., Campbell, Norman R.C., Padwal, Raj, Campbell, Tavis S., Patrice Lindsay, M., Hill, Michael D., Quinn, Robert R., Mahon, Jeff L., Herman, Robert J., Schiffrin, Ernesto L., Ruzicka, Marcel, Larochelle, Pierre, Feldman, Ross D., Lebel, Marcel, Poirier, Luc, Arnold, J. Malcolm O., Moe, Gordon W., Howlett, Jonathan G., Trudeau, Luc, Bacon, Simon L., Petrella, Robert J., Milot, Alain, Stone, James A., Drouin, Denis, Boulanger, Jean-Martin, Sharma, Mukul, Hamet, Pavel, Fodor, George, Dresser, George K., George Carruthers, S., Pylypchuk, George, Burgess, Ellen D., Burns, Kevin D., Vallée, Michel, Ramesh Prasad, G.V., Gilbert, Richard E., Leiter, Lawrence A., Jones, Charlotte, Ogilvie, Richard I., Woo, Vincent, McFarlane, Philip A., Hegele, Robert A., and Tobe, Sheldon W.

Published
2010
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17. Effect of B-vitamin therapy on progression of diabetic nephropathy

Author

House, Andrew A., Eliasziw, Misha, Cattran, Daniel C., Churchill, David N., Oliver, Matthew J., Fine, Adrian, Dresser, George K., and Spence, J, David

Subjects
Diabetic nephropathies -- Drug therapy, Vitamin B -- Health aspects, Vitamin B -- Dosage and administration, Vitamin B complex -- Health aspects, Vitamin B complex -- Dosage and administration, Blood circulation disorders -- Prevention
Abstract

A study was conducted to evaluate the efficacy of vitamin B in slowing the progression of diabetic nephropathy as well as prevent vascular complications. Results indicated that high doses of vitamin B did significantly reduce such complications.

Published
2010

20. Contributors

Author

Abramovitz, Blaise W., Agarwal, Rajiv, Ahmad, Sarah, Alexander, Matthew R., AlQassas, Ibrahim A., Arroyo, Juan P., Asuzu, Christopher, Ayesh, Ali, Bakris, George, Bali, Atul, Beckman, Joshua A., Bock, Fabian, Bugeja, Ann, Burgner, Anna, Carey, Robert M., Cohen, Jordana B., Concepcion, Beatrice P., Dillingham, Christine, Drager, Luciano F., Dresser, George K., Eknoyan, Garabed, Ellison, David, Erdbrugger, Uta, Farrell, Maureen C., Flood, Ryan P., Flynn, Joseph T., Georgianos, Panagiotis I., Gilligan, Sarah, McAuliffe, Christin Giordano, Hiremath, Swapnil, Holder, Tara A., Hu, Jiun-Ruey, Husain, Irma, Imran, Nashat, Judd, Eric, Kharadjian, Talar B., Kim, Esther S., Kovach, Cassandra, Kumar, Arun, Lerma, Edgar V., Lewis, Julia B., Libianto, Renata, Lloyd, Matthew, Luther, James M., Malhotra, Rakesh, Mehta, Hina N., Montford, John R., Mosley, Jonathan D., Munir, Bilal, Padwal, Raj, Patel, Trisha, Peixoto, Aldo J., Pradhan, Nishigandha, Pratt, J. Howard, Puar, Akshan, Rabkin, Simon W., Rahman, Mahboob, Raj, Satish R., Ramkumar, Nirupama, Rianto, Fitra, Ringrose, Jennifer, Ruzicka, Marcel, Schiavon, Carlos A., Shamy, Michel, Shawar, Saed, Shibao, Cyndya A., Sparks, Matthew A., Sternlicht, Hillel, Sussman, Craig, Terker, Andrew, Tezuka, Yuta, Tran, Karen C., Turcu, Adina F., Vaidya, Anand, and Yang, Jun

Published
2023
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25. Accelerated surgery versus standard care in hip fracture (HIP ATTACK): an international, randomised, controlled trial

Author

Borges, Flavia K, primary, Bhandari, Mohit, additional, Guerra-Farfan, Ernesto, additional, Patel, Ameen, additional, Sigamani, Alben, additional, Umer, Masood, additional, Tiboni, Maria E, additional, Villar-Casares, Maria del Mar, additional, Tandon, Vikas, additional, Tomas-Hernandez, Jordi, additional, Teixidor-Serra, Jordi, additional, Avram, Victoria RA, additional, Winemaker, Mitchell, additional, Ramokgopa, Mmampapatla T, additional, Szczeklik, Wojciech, additional, Landoni, Giovanni, additional, Wang, Chew Yin, additional, Begum, Dilshad, additional, Neary, John D, additional, Adili, Anthony, additional, Sancheti, Parag K, additional, Lawendy, Abdel-Rahman, additional, Balaguer-Castro, Mariano, additional, Ślęczka, Paweł, additional, Jenkinson, Richard J, additional, Nur, Aamer Nabi, additional, Wood, Gavin CA, additional, Feibel, Robert J, additional, McMahon, Stephen J, additional, Sigamani, Alen, additional, Popova, Ekaterine, additional, Biccard, Bruce M, additional, Moppett, Iain K, additional, Forget, Patrice, additional, Landais, Paul, additional, McGillion, Michael H, additional, Vincent, Jessica, additional, Balasubramanian, Kumar, additional, Harvey, Valerie, additional, Garcia-Sanchez, Yaiza, additional, Pettit, Shirley M, additional, Gauthier, Leslie P, additional, Guyatt, Gordon H, additional, Conen, David, additional, Garg, Amit X, additional, Bangdiwala, Shrikant I, additional, Belley-Cote, Emilie P, additional, Marcucci, Maura, additional, Lamy, Andre, additional, Whitlock, Richard, additional, Le Manach, Yannick, additional, Fergusson, Dean A, additional, Yusuf, Salim, additional, Devereaux, PJ, additional, Veevaete, Laurent, additional, le Polain de Waroux, Bernard, additional, Lavand'homme, Patricia, additional, Cornu, Olivier, additional, Tribak, Karim, additional, Yombi, Jean Cyr, additional, Touil, Nassim, additional, Reul, Maike, additional, Bhutia, Jigme Tshering, additional, Clinckaert, Carol, additional, De Clippeleir, Dirk, additional, de Beer, Justin, additional, Simpson, Diane L, additional, Worster, Andrew, additional, Alvarado, Kim A, additional, Gregus, Krysten K, additional, Lawrence, Kelly H, additional, Leong, Darryl P, additional, Joseph, Philip G, additional, Magloire, Patrick, additional, Deheshi, Benjamin, additional, Bisland, Stuart, additional, Wood, Thomas J, additional, Tushinski, Daniel M, additional, Wilson, David AJ, additional, Kearon, Clive, additional, Cowan, David D, additional, Khanna, Vickas, additional, Zaki, Amna, additional, Farrell, Janet C, additional, MacDonald, Anne Marie, additional, Wong, Steven CW, additional, Karbassi, Arsha, additional, Wright, Douglas Steven, additional, Shanthanna, Harsha, additional, Coughlin, Ryan, additional, Khan, Moin, additional, Wikkerink, Spencer, additional, Quraishi, Faraaz A, additional, Kishta, Waleed, additional, Schemitsch, Emil, additional, Carey, Timothy, additional, Macleod, Mark D, additional, Sanders, David W, additional, Vasarhelyi, Edward, additional, Bartley, Debra, additional, Dresser, George K, additional, Tieszer, Christina, additional, Shadowitz, Steven, additional, Lee, Jacques S, additional, Choi, Stephen, additional, Kreder, Hans J, additional, Nousiainen, Markku, additional, Kunz, Monica R, additional, Tuazon, Ravianne, additional, Shrikumar, Mopina, additional, Ravi, Bheeshma, additional, Wasserstein, David, additional, Stephen, David JG, additional, Nam, Diane, additional, Henry, Patrick DG, additional, Mann, Stephen M, additional, Jaeger, Melanie T, additional, Sivilotti, Marco LA, additional, Smith, Christopher A, additional, Frank, Christopher C, additional, Grant, Heather, additional, Ploeg, Leone, additional, Yach, Jeff D, additional, Harrison, Mark M, additional, Campbell, Aaron R, additional, Bicknell, Ryan T, additional, Bardana, Davide D, additional, McIlquham, Katie, additional, Gallant, Catherine, additional, Halman, Samantha, additional, Thiruganasambandamoorth, Venkatesh, additional, Ruggiero, Sara, additional, Hadden, William J, additional, Chen, Brian P-J, additional, Coupal, Stephanie A, additional, McLean, Lisa M, additional, Shirali, Hemant R, additional, Haider, Syed Y, additional, Smith, Crystal A, additional, Watts, Evan, additional, Santone, David J, additional, Koo, Kevin, additional, Yee, Allan J, additional, Oyenubi, Ademilola N, additional, Nauth, Aaron, additional, Schemitsch, Emil H, additional, Daniels, Timothy R, additional, Ward, Sarah E, additional, Hall, Jeremy A, additional, Ahn, Henry, additional, Whelan, Daniel B, additional, Atrey, Amit, additional, Khoshbin, Amir, additional, Puskas, David, additional, Droll, Kurt, additional, Cullinan, Claude, additional, Payendeh, Jubin, additional, Lefrancois, Tina, additional, Mozzon, Lise, additional, Marion, Travis, additional, Jacka, Michael J, additional, Greene, James, additional, Menon, Matthew, additional, Stiegelmahr, Robert, additional, Dillane, Derek, additional, Irwin, Marleen, additional, Beaupre, Lauren, additional, Coles, Chad P, additional, Trask, Kelly, additional, MacDonald, Shelley, additional, Trenholm, J Andrew I, additional, Oxner, William, additional, Richardson, C Glen, additional, Dehghan, Niloofar, additional, Sadoughi, Mehdi, additional, Sharma, Achal, additional, White, Neil J, additional, Olivieri, Loretta, additional, Hunt, Stephen B, additional, Turgeon, Thomas R, additional, Bohm, Eric R, additional, Tran, Sarah, additional, Giilck, Stephen M, additional, Hupel, Tom, additional, Guy, Pierre, additional, O'Brien, Peter J, additional, Duncan, Andrew W, additional, Crawford, Gordon A, additional, Zhou, Junlin, additional, Zhao, Yanrui, additional, Liu, Yang, additional, Shan, Lei, additional, Wu, Anshi, additional, Muñoz, Juan Manuel, additional, Chaudier, Philippe, additional, Douplat, Marion, additional, Fessy, Michel Henri, additional, Piriou, Vincent, additional, Louboutin, Lucie, additional, David, Jean Stephane, additional, Friggeri, Arnaud, additional, Beroud, Sebastien, additional, Fayet, Jean Marie, additional, Leung, Frankie Ka Li, additional, Fang, Christian Xinshuo, additional, Yee, Dennis King Hang, additional, Sancheti, Parag Kantilal, additional, Pradhan, Chetan Vijay, additional, Patil, Atul Ashok, additional, Puram, Chetan Prabhakar, additional, Borate, Madhav Pandurang, additional, Kudrimoti, Kiran Bhalchandra, additional, Adhye, Bharati Anil, additional, Dongre, Himanshu Vijaykumar, additional, John, Bobby, additional, Abraham, Valsamma, additional, Pandey, Ritesh Arvind, additional, Rajkumar, Arti, additional, George, Preetha Elizabeth, additional, Stephen, Manesh, additional, Chandran, Nitheesh, additional, Ashraf, Mohammed, additional, Georgekutty, AM, additional, Sulthan, Ahamad Shaheel, additional, Adinarayanan, S, additional, Sharma, Deep, additional, Barnawal, Satish Prasad, additional, Swaminathan, Srinivasan, additional, Bidkar, Prasanna Udupi, additional, Mishra, Sandeep Kumar, additional, Menon, Jagdish, additional, M, Niranjan, additional, K, Varghese Zachariah, additional, Hiremath, Santosh Angad, additional, NC, Madhusudhan, additional, Jawali, Abhijit, additional, Gnanadurai, Kingsly Robert, additional, George, Carolin Elizabeth, additional, Maddipati, Tatarao, additional, KP, Mary KP, additional, Sharma, Vijay, additional, Farooque, Kamran, additional, Malhotra, Rajesh, additional, Mittal, Samarth, additional, Sawhney, Chavi, additional, Gupta, Babita, additional, Mathur, Purva, additional, Gamangati, Shivanand, additional, Tripathy, Vijaylaxmi, additional, Menon, Prem Haridas, additional, Dhillon, Mandeep S, additional, Chouhan, Devendra K, additional, Patil, Sharanu, additional, Narayan, Ravi, additional, Lal, Purushotham, additional, Bilchod, Prashanth Nabhirajappa, additional, Singh, Surya Udai, additional, Gattu, Uttam Vaidya, additional, Dashputra, Ravi Prabhakar, additional, Rahate, Prashant Vitthal, additional, Turiel, Maurizio, additional, De Blasio, Giuseppe, additional, Accetta, Riccardo, additional, Perazzo, Paolo, additional, Stella, Daniele, additional, Bonadies, Marika, additional, Colombo, Chiara, additional, Fozzato, Stefania, additional, Pino, Fabio, additional, Morelli, Ilaria, additional, Colnaghi, Eleonora, additional, Salini, Vincenzo, additional, Denaro, Giuseppe, additional, Beretta, Luigi, additional, Placella, Giacomo, additional, Giardina, Giuseppe, additional, Binda, Mirko, additional, Marcato, Anna, additional, Guzzetti, Luca, additional, Piccirillo, Fabio, additional, Cecconi, Maurizio, additional, Khor, HM, additional, Lai, Hou Yee, additional, Kumar, CS, additional, Chee, KH, additional, Loh, PS, additional, Tan, Kit Mun, additional, Singh, Simmrat, additional, Foo, Li Lian, additional, Prakasam, Komella, additional, Chaw, Sook Hui, additional, Lee, Meng-Li, additional, Ngim, Joanne HL, additional, Boon, Huck Wee, additional, Chin, Im Im, additional, Kleinlugtenbelt, Ydo V, additional, Landman, Ellie BM, additional, Flikweert, Elvira R, additional, Roerdink, Herbert W, additional, Brokelman, Roy B.G., additional, Elskamp-Meijerman, Hannie F, additional, Horst, Maarten R, additional, Cobben, Jan-Hein MG, additional, Anjum, Anila, additional, Hashmi, Pervaiz Mehmood, additional, Ahmed, Tashfeen, additional, Rashid, Haroon Ur, additional, Khattak, Mujahid Jamil, additional, Rashid, Rizwan Haroon, additional, Lakdawala, Riaz Hussain, additional, Noordin, Shahryar, additional, Juman, Naveed Muhammed, additional, Khan, Robyna Irshad, additional, Riaz, Muhammad Mehmood, additional, Bokhari, Syedah Saira, additional, Almas, Ayesha, additional, Wahab, Hussain, additional, Ali, Arif, additional, Khan, Hammad Naqi, additional, Khan, Eraj Khurshid, additional, Janjua, Kholood Abid, additional, Orakzai, Sajjad Hassan, additional, Khan, Abdus Salam, additional, Mustafa, Khawaja Junaid, additional, Sohail, Mian Amjad, additional, Umar, Muhammad, additional, Khan, Siddra Ahmed, additional, Ashraf, Muhammad, additional, Khan, Muhammad Kashif, additional, Shiraz, Muhammad, additional, Furgan, Ahmad, additional, Dąbek, Piotr, additional, Kumoń, Adam, additional, Satora, Wojciech, additional, Ambroży, Wojciech, additional, Święch, Mariusz, additional, Rycombel, Jacek, additional, Grzelak, Adrian, additional, Gucwa, Jaroslaw, additional, Machala, Waldemar, additional, Ramokgopa, Mmampapatla Thomas, additional, Firth, Gregory Bodley, additional, Karera, Mwalimu, additional, Fourtounas, Maria, additional, Singh, Virsen, additional, Biscardi, Anna, additional, Iqbal, Muhammad Nasir, additional, Campbell, Ryan Jonathan, additional, Maluleke, Matimba Lenny, additional, Moller, Carien, additional, Nhlapo, Lerato, additional, Maqungo, Sithombo, additional, Flint, Margot, additional, Nejthardt, Marcin B, additional, Chetty, Sean, additional, Naidoo, Rubendren, additional, Garrido Clua, Miriam, additional, Molero-Garcia, Vicente, additional, Minguell-Monyart, Joan, additional, Selga Marsa, Jordi, additional, Porcel-Vazquez, Juan A, additional, Andres-Peiro, Jose-Vicente, additional, Aguilar, Marc, additional, Mestre-Torres, Jaume, additional, Colomina, Maria J, additional, Guilabert, Patricia, additional, Paños Gozalo, M Luisa, additional, Abarca, Luis, additional, Martin, Nuria, additional, Usua, Gemma, additional, Martinez-Ripol, Pedro, additional, Gonzalez Posada, MA, additional, Lalueza-Broto, Pilar, additional, Sanchez-Raya, Judith, additional, Nuñez Camarena, Jorge, additional, Fraguas-Castany, Antoni, additional, Torner, Pere, additional, Jornet-Gibert, Monsant, additional, Serrano-Sanz, Jorge, additional, Cámara-Cabrera, Jaume, additional, Salomó-Domènech, Mònica, additional, Yela-Verdú, Christian, additional, Peig-Font, Anna, additional, Ricol, Laura, additional, Carreras-Castañer, Anna, additional, Martínez-Sañudo, Luis, additional, Herranz, Susana, additional, Feijoo-Massó, Carlos, additional, Sianes-Gallén, Mònica, additional, Castillón, Pablo, additional, Bernaus, Martí, additional, Quintas, Saioa, additional, Gómez, Olga, additional, Salvador, Jordi, additional, Abarca, Javiera, additional, Estrada, Cristina, additional, Novellas, Marga, additional, Torra, Mercè, additional, Dealbert, Alfred, additional, Macho, Oscar, additional, Ivanov, Alexia, additional, Valldosera, Esther, additional, Arroyo, Marta, additional, Pey, Borja, additional, Yuste, Antoni, additional, Mateo, Llorenç, additional, De Caso, Julio, additional, Anaya, Rafael, additional, Higa-Sansone, JL, additional, Millan, Angelica, additional, Baños, Victoria, additional, Herrera-Mateo, Sergio, additional, Aguado, Hector J, additional, Martinez-Municio, Gonzalo, additional, León, Ricardo, additional, Santiago-Maniega, Silvia, additional, Zabalza, Ana, additional, Labrador, Gregorio, additional, Guerado, Enrique, additional, Cruz, Encarnacion, additional, Cano, Juan Ramon, additional, Bogallo, Jose Manuel, additional, Sa-ngasoongsong, Paphon, additional, Kulachote, Noratep, additional, Sirisreetreerux, Norachart, additional, Pengrung, Nachapan, additional, Chalacheewa, Theerawat, additional, Arnuntasupakul, Vanlapa, additional, Yingchoncharoen, Teerapat, additional, Naratreekoon, Bundit, additional, Kadry, Miriam Adel, additional, Thayaparan, Surendini, additional, Abdlaziz, Ihab, additional, Aframian, Arash, additional, Imbuldeniya, Arjuna, additional, Bentoumi, Souad, additional, Omran, Sherif, additional, Vizcaychipi, Marcela Paola, additional, Correia, Patricia, additional, Patil, Shashank, additional, Haire, Kevin, additional, Mayor, Amy SE, additional, Dillingham, Sally, additional, Nicholson, Laura, additional, Elnaggar, Mohamed, additional, John, Joby, additional, Nanjayan, Shashi Kumar, additional, Parker, Martyn J, additional, O'Sullivan, Susan, additional, Marmor, Meir T, additional, Matityahu, Amir, additional, McClellan, Robert Trigg, additional, Comstock, Curt, additional, Ding, Anthony, additional, Toogood, Paul, additional, Slobogean, Gerard, additional, Joseph, Katherine, additional, O'Toole, Robert, additional, Sciadini, Marcus, additional, Ryan, Scott P, additional, Clark, Molly E, additional, Cassidy, Charles, additional, Balonov, Konstantin, additional, Bergese, Sergio D, additional, Phieffer, Laura S, additional, Gonzalez Zacarias, Alicia A, additional, Marcantonio, Andrew J, additional, Borges, Flavia K, additional, Dragic-Taylor, Sanela, additional, Maxwell, Chelsea, additional, Molnar, Sarah, additional, Wells, Jennifer R, additional, Ofori, Sandra N, additional, Yang, Stephen S, additional, Wang, Michael K, additional, Duceppe, Emmanuelle, additional, Spence, Jessica, additional, Vasquez, Javiera P, additional, Marcano-Fernández, Francesc, additional, Ham, Hyungjoo, additional, Prada, Carlos, additional, Yung, Terence CH, additional, Sanz Pérez, Isidro, additional, Bosch, Michael J, additional, Prystajecky, Michael R, additional, Chowdhury, Chinmoy, additional, Khan, James S, additional, Stella, Steffan F, additional, Heidary, Behrouz, additional, Tran, Allen, additional, Wawrzycka-Adamczyk, Katarzyna, additional, Chen, Yu Chiao Peter, additional, González-Osuna, Aránzazu, additional, Biedroń, Grzegorz, additional, Wludarczyk, Anna, additional, Lefebvre, Marco, additional, Ernst, Jaclyn A, additional, Staffhorst, Bas, additional, Woodfine, Jason D, additional, Alwafi, Emad M, additional, Mrkobrada, Marko, additional, Parlow, Simon, additional, Roberts, Robin, additional, McAlister, Finlay, additional, Sackett, David, additional, and Wright, James, additional

Published
2020
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26. Risk of stroke and other adverse outcomes in patients with perioperative atrial fibrillation 1 year after non-cardiac surgery

Author

Conen, David, Alonso-Coello, Pablo, Douketis, James, Chan, Matthew T. V., Kurz, Andrea, Sigamani, Alben, Parlow, Joel L., Wang, Chew Yin, Villar, Juan C., Srinathan, Sadeesh K., Tiboni, Maria, Málaga Rodríguez, Germán Javier, Guyatt, Gordon, Sivakumaran, Soori, Rodriguez Funes, Maria-Virginia, Cruz, Patricia, Yang, Homer, Dresser, George K., Alvarez-Garcia, Jesus, Schricker, Thomas, Jones, Philip M., Drummond, Leanne W., Balasubramanian, Kumar, Yusuf, Salim, and Devereaux, P. J.

Subjects
cardiovascular risk, adverse outcome, conservative treatment, mortality rate, Cardiovascular, postoperative period, Article, male, follow up, atrial fibrillation, controlled study, purl.org/pe-repo/ocde/ford#3.02.04 [https], Perioperative, human, Mortality, clonidine, risk reduction, drug effect, high risk population, acetylsalicylic acid, cohort analysis, major clinical study, metoprolol, Stroke, peroperative complication, aged, female, priority journal, risk factor, randomized controlled trial, incidence, placebo, mortality risk, cerebrovascular accident
Abstract

AIMS: To determine the 1-year risk of stroke and other adverse outcomes in patients with a new diagnosis of perioperative atrial fibrillation (POAF) after non-cardiac surgery. METHODS AND RESULTS: The PeriOperative ISchemic Evaluation (POISE)-1 trial evaluated the effects of metoprolol vs. placebo in 8351 patients, and POISE-2 compared the effect of aspirin vs. placebo, and clonidine vs. placebo in 10 010 patients. These trials included patients with, or at risk of, cardiovascular disease who were undergoing non-cardiac surgery. For the purpose of this study, we combined the POISE datasets, excluding 244 patients who were in atrial fibrillation (AF) at the time of randomization. Perioperative atrial fibrillation was defined as new AF that occurred within 30 days after surgery. Our primary outcome was the incidence of stroke at 1 year of follow-up; secondary outcomes were mortality and myocardial infarction (MI). We compared outcomes among patients with and without POAF using multivariable adjusted Cox proportional hazards models. Among 18 117 patients (mean age 69 years, 57.4% male), 404 had POAF (2.2%). The stroke incidence 1 year after surgery was 5.58 vs. 1.54 per 100 patient-years in patients with and without POAF, adjusted hazard ratio (aHR) 3.43, 95% confidence interval (CI) 2.00-5.90; P < 0.001. Patients with POAF also had an increased risk of death (incidence 31.37 vs. 9.34; aHR 2.51, 95% CI 2.01-3.14; P < 0.001) and MI (incidence 26.20 vs. 8.23; aHR 5.10, 95% CI 3.91-6.64; P < 0.001). CONCLUSION: Patients with POAF have a significantly increased risk of stroke, MI, and death at 1 year. Intervention studies are needed to evaluate risk reduction strategies in this high-risk population.

Published
2019

41. Risk of stroke and other adverse outcomes in patients with perioperative atrial fibrillation 1 year after non-cardiac surgery

Author

Conen, David, primary, Alonso-Coello, Pablo, additional, Douketis, James, additional, Chan, Matthew T V, additional, Kurz, Andrea, additional, Sigamani, Alben, additional, Parlow, Joel L, additional, Wang, Chew Yin, additional, Villar, Juan C, additional, Srinathan, Sadeesh K, additional, Tiboni, Maria, additional, Malaga, German, additional, Guyatt, Gordon, additional, Sivakumaran, Soori, additional, Rodriguez Funes, Maria-Virginia, additional, Cruz, Patricia, additional, Yang, Homer, additional, Dresser, George K, additional, Alvarez-Garcia, Jesus, additional, Schricker, Thomas, additional, Jones, Philip M, additional, Drummond, Leanne W, additional, Balasubramanian, Kumar, additional, Yusuf, Salim, additional, and Devereaux, P J, additional

Published
2019
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42. Fexofenadine and Rosuvastatin Pharmacokinetics in Mice with Targeted Disruption of Organic Anion Transporting Polypeptide 2B1

Author

Medwid, Samantha, primary, Li, Mandy M.J., additional, Knauer, Michael J., additional, Lin, Kathleen, additional, Mansell, Sara E., additional, Schmerk, Crystal L., additional, Zhu, Catherine, additional, Griffin, Katelyn E., additional, Yousif, Mohamed D., additional, Dresser, George K., additional, Schwarz, Ute I., additional, Kim, Richard B., additional, and Tirona, Rommel G., additional

Published
2019
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43. Risk of stroke and other adverse outcomes in patients with perioperative atrial fibrillation 1 year after non-cardiac surgery.

Author

Conen, David, Alonso-Coello, Pablo, Douketis, James, Chan, Matthew T V, Kurz, Andrea, Sigamani, Alben, Parlow, Joel L, Wang, Chew Yin, Villar, Juan C, Srinathan, Sadeesh K, Tiboni, Maria, Malaga, German, Guyatt, Gordon, Sivakumaran, Soori, Funes, Maria-Virginia Rodriguez, Cruz, Patricia, Yang, Homer, Dresser, George K, Alvarez-Garcia, Jesus, and Schricker, Thomas

Abstract

Aims To determine the 1-year risk of stroke and other adverse outcomes in patients with a new diagnosis of perioperative atrial fibrillation (POAF) after non-cardiac surgery. Methods and results The PeriOperative ISchemic Evaluation (POISE)-1 trial evaluated the effects of metoprolol vs. placebo in 8351 patients, and POISE-2 compared the effect of aspirin vs. placebo, and clonidine vs. placebo in 10 010 patients. These trials included patients with, or at risk of, cardiovascular disease who were undergoing non-cardiac surgery. For the purpose of this study, we combined the POISE datasets, excluding 244 patients who were in atrial fibrillation (AF) at the time of randomization. Perioperative atrial fibrillation was defined as new AF that occurred within 30 days after surgery. Our primary outcome was the incidence of stroke at 1 year of follow-up; secondary outcomes were mortality and myocardial infarction (MI). We compared outcomes among patients with and without POAF using multivariable adjusted Cox proportional hazards models. Among 18 117 patients (mean age 69 years, 57.4% male), 404 had POAF (2.2%). The stroke incidence 1 year after surgery was 5.58 vs. 1.54 per 100 patient-years in patients with and without POAF, adjusted hazard ratio (aHR) 3.43, 95% confidence interval (CI) 2.00–5.90; P  < 0.001. Patients with POAF also had an increased risk of death (incidence 31.37 vs. 9.34; aHR 2.51, 95% CI 2.01–3.14; P  < 0.001) and MI (incidence 26.20 vs. 8.23; aHR 5.10, 95% CI 3.91–6.64; P  < 0.001). Conclusion Patients with POAF have a significantly increased risk of stroke, MI, and death at 1 year. Intervention studies are needed to evaluate risk reduction strategies in this high-risk population. Open in new tab Download slide Open in new tab Download slide [ABSTRACT FROM AUTHOR]

Published
2020
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44. Dabigatran in patients with myocardial injury after non-cardiac surgery (MANAGE): an international, randomised, placebo-controlled trial

Author

Devereaux, P J, primary, Duceppe, Emmanuelle, additional, Guyatt, Gordon, additional, Tandon, Vikas, additional, Rodseth, Reitze, additional, Biccard, Bruce M, additional, Xavier, Denis, additional, Szczeklik, Wojciech, additional, Meyhoff, Christian S, additional, Vincent, Jessica, additional, Franzosi, Maria Grazia, additional, Srinathan, Sadeesh K, additional, Erb, Jason, additional, Magloire, Patrick, additional, Neary, John, additional, Rao, Mangala, additional, Rahate, Prashant V, additional, Chaudhry, Navneet K, additional, Mayosi, Bongani, additional, de Nadal, Miriam, additional, Iglesias, Pilar Paniagua, additional, Berwanger, Otavio, additional, Villar, Juan Carlos, additional, Botto, Fernando, additional, Eikelboom, John W, additional, Sessler, Daniel I, additional, Kearon, Clive, additional, Pettit, Shirley, additional, Sharma, Mukul, additional, Connolly, Stuart J, additional, Bangdiwala, Shrikant I, additional, Rao-Melacini, Purnima, additional, Hoeft, Andreas, additional, Yusuf, Salim, additional, Devereaux, P.J., additional, Bangdiwala, Shrikant I., additional, Connolly, Stuart, additional, Eikelboom, John, additional, Pogue, Janice, additional, Sessler, Daniel I., additional, Di Diodato, Sara, additional, Gasic, Zora, additional, Mastrangelo, Louise J., additional, Molnar, Sarah H., additional, Swanson, Jennifer L., additional, Tosh, Makayla L., additional, Wells, Jennifer R., additional, Diaz, Rafael, additional, Chow, Clara K., additional, Gonzales, Beatriz, additional, Vásquez, Skarlet, additional, Jansky, Petr, additional, Dušek, Radovan, additional, Meyhoff, Christian S., additional, Coriat, Pierre, additional, Wittmann, Maria, additional, Yonga, Gerald, additional, Mathur, Nandini, additional, Seletti, Elena, additional, Malaga, German, additional, Tumanan-Mendoza, Bernadette A., additional, Tagle, Maria Pamela A., additional, Biccard, Bruce M., additional, Alonso-Coello, Pablo, additional, Popova, Ekaterine, additional, Shields, Martin, additional, Le Manach, Yannick, additional, Moayyedi, Paul, additional, van Zanten, Sander, additional, Fleischmann, Edith, additional, Garg, Amit, additional, Karaye, Kamilu, additional, McFalls, Edward, additional, Sigamani, Alben, additional, Belley-Côté, Emilie, additional, Biedroń, Grzegorz, additional, Borges, Flavia, additional, Frosi Stella, Steffan, additional, Haarmark Nielsen, Christian, additional, Leong, Darryl P., additional, Spence, Jessica, additional, Tran, Allen, additional, Wawrzycka-Adamczyk, Katarzyna, additional, Yang, Stephen S., additional, Yung, Terence, additional, Wyse, D. George, additional, Cheng, Davy, additional, Johnstone, David E., additional, Wells, George A., additional, Joseph, Philip, additional, Patel, Ameen, additional, Gregus, Krysten, additional, Lawrence, Kelly, additional, Doharris, Lindsay, additional, Conen, David, additional, Cheung, Jason, additional, Douketis, Jim, additional, Wright, Douglas, additional, Wikkerink, Spencer, additional, Dechert, William, additional, Panju, Mohamed, additional, Azzam, Khalid, additional, Rapanos, Theodore, additional, Van Helder, Tomas, additional, Shroff, Anjali, additional, Hare, Jacqueline, additional, Kidane, Biniam, additional, Nguyen, Thang, additional, Leydier, Larissa, additional, Bayaraa, Vanessa, additional, Parlow, Joel, additional, DuMerton, Deborah A., additional, Thakrar, Amar, additional, Shelley, Jessica, additional, Deligne, Benoit, additional, Carling, Roberta Daila, additional, Mrkobrada, Marko, additional, Dresser, George K., additional, Jacka, Michael J., additional, Hornstein, David, additional, Winkelaar, Gerrit B., additional, Haider, Zoeb Hussain, additional, Lanjewar, Pravina Prashant, additional, Varughese, Valsamma, additional, Calton, Rajneesh, additional, Ahuja, Hemani, additional, George, Preetha, additional, Sharma, Ambika, additional, Bhatt, Keyur Sureshchandra, additional, Mangukiya, Dhaval Odhavajibhai, additional, Nandaniya, Karshan Vira, additional, Parekh, Viral Vasantrai, additional, Pillai, Ashok Bhaskaran, additional, Menon, Vidya P., additional, Desai, Sanjay Channappa, additional, Sidhu, Ravinder Singh, additional, Gupta, Sandeep Kumar, additional, George, Robbie K., additional, Gurunath, T.R., additional, Drummond, Leanne W., additional, Torborg, Alexandra M., additional, Küsel, Belinda S., additional, Naidoo, Prebashini, additional, Naidoo, Datshana P., additional, Rajah, Chantal, additional, Farina, Zane, additional, von Rahden, Richard Peter, additional, Gumede, Simphiwe, additional, Chishala, Chishala, additional, Coetzee, Ettienne, additional, Dyer, Robert A., additional, Diedericks, Johan, additional, Bielański, Piotr, additional, Kaczmarek, Bogusz, additional, Studzińska, Dorota, additional, Zaniewski, Maciej, additional, Libura, Marek Józef, additional, Zacharias-Nalichowski, Tomasz Mikołaj, additional, Sega, Aurelia A.S., additional, Salwa, Jakub, additional, Kózka, Mateusz, additional, Górka, Jacek, additional, Wludarczyk, Anna, additional, Nowak-Kózka, Ilona, additional, Grudzień, Paweł Szczepan, additional, Gucwa, Jaroslaw W., additional, Słowiaczek, Michał Piotr, additional, Dobosz, Paweł P.D., additional, Gögenur, Ismail, additional, Eriksen, Jens Ravn, additional, Borup, Tine, additional, Kirkegaard, Tove, additional, Isbye, Dan, additional, Sonne, Asger, additional, Rasmussen, Lars S., additional, Pedersen, Sofie, additional, Troensegaard, Hannibal, additional, Duus, Camilla L., additional, Halle, Benedikte M., additional, Gundel, Ossian N., additional, Bernholm, Katrine F., additional, Martinsen, Kristian Rønsholt, additional, Pedersen, Søren, additional, Itenov, Theis S., additional, Camio, Elena, additional, Vázquez, Carles, additional, Matarin, Silvia, additional, Cano, Esther, additional, Álvarez-García, Jesús, additional, India, Inmaculada, additional, González-Osuna, Aránzazu, additional, Vives, Marc, additional, Rosselló, Elena, additional, Serrano, Ana B., additional, Turiel, Maurizio, additional, Drago, Lorenzo, additional, Colombo, Chiara, additional, Marra, Federica, additional, Mos, Lucio, additional, Arteni, Franco, additional, Lembo, Rosalba, additional, Ortalda, Alessandro, additional, Passarani, Simonetta, additional, Mokini, Zhirajr, additional, Figueiredo, Estevao Lanna, additional, Werner, Gustavo Fonseca, additional, Petriz, Joao Luiz, additional, Maia, Lilia Nigro, additional, Bergo, Ricardo R., additional, Precoma, Dalton Bertolim, additional, Saraiva, José Francisco Kerr, additional, Vilamajo, Oscar Gomez, additional, Allegrini, Eduardo, additional, Benzadón, Mariano, additional, Parody, Maria Leonor, additional, Duronto, Ernesto A., additional, Ingaramo, Adrián C., additional, Parra, Gustavo Adolfo, additional, Novoa, Danny, additional, Miller, Scott A., additional, Thomas, Sabu, additional, Karlapudi, Sudhakar P., additional, Bourji, Mohamad H., additional, Banerjee, Subhash, additional, Gupta, Anita, additional, Opole, Isaac O., additional, Fischer, Michal, additional, Mendoza, Victor Lecaros, additional, Reyes, Eugenio Borja, additional, Pierson, Richard J., additional, Shields, Martin O., additional, Piriou, Vincent, additional, Zacharowski, Kai, additional, Rotta-Rotta, Aida, additional, Paper, Main, additional, Srinathan, Sadeesh K., additional, Rahate, Prashant, additional, Chaudhry, Navneet, additional, Mayosi, Bogani, additional, Paniagua Iglesias, Pilar, additional, and Sharma, Mike, additional

Published
2018
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