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301 results on '"Dreher, Matthew R."'

1. Feasibility of Combination Intra-arterial Yttrium-90 and Irinotecan Microspheres in the VX2 Rabbit Model.

Author

Gordon, Andrew C, White, Sarah B, Yang, Yihe, Gates, Vanessa L, Procissi, Daniel, Harris, Kathleen R, Zhang, Zhuoli, Lyu, Tianchu, Huang, Xiaoke, Dreher, Matthew R, Omary, Reed A, Salem, Riad, Lewandowski, Robert J, and Larson, Andrew C

Subjects
Animals, Rabbits, Liver Neoplasms, Experimental, Disease Models, Animal, Necrosis, Yttrium Radioisotopes, Antineoplastic Agents, Magnetic Resonance Imaging, Chemoembolization, Therapeutic, Feasibility Studies, Microspheres, Dose-Response Relationship, Drug, Irinotecan, Chemoembolization, Magnetic resonance imaging, Radioembolization, Yttrium-90, Digestive Diseases, Rare Diseases, Cancer, Cardiorespiratory Medicine and Haematology, Nuclear Medicine & Medical Imaging
Abstract

PurposeTo evaluate the combination of 90Y radioembolization (Y90) and drug-eluting bead irinotecan (DEBIRI) microspheres in the VX2 rabbit model.Materials and methodsAn initial dose finding study was performed in 6 White New Zealand rabbits to identify a therapeutic but subcurative dose of Y90. In total, 29 rabbits were used in four groups: Y90 treatment (n = 8), DEBIRI treatment (n = 6), Y90 + DEBIRI treatment (n = 7), and an untreated control group (n = 8). Hepatic toxicity was evaluated at baseline, 24 h, 72 h, 1 week, and 2 weeks. MRI tumor volume (TV) and enhancing tumor volume were assessed baseline and 2 weeks. Tumor area and necrosis were evaluated on H&E for pathology.ResultsInfused activities of 84.0-94.4 MBq (corresponding to 55.1-72.7 Gy) were selected based on the initial dose finding study. Infusion of DEBIRI after Y90 was technically feasible in all cases (7/7). Overall, 21/29 animals survived to 2 weeks, and the remaining animals had extrahepatic disease on necropsy. Liver transaminases were elevated with Y90, DEBIRI, and Y90 + DEBIRI compared to control at 24 h, 72 h, and 1 week post-treatment and returned to baseline by 2 weeks. By TV, Y90 + DEBIRI was the only treatment to show statistically significant reduction at 2 weeks compared to the control group (p = 0.012). The change in tumor volume (week 2-baseline) for both Y90 + DEBIRI versus control (p = 0.002) and Y90 versus control (p = 0.014) was significantly decreased. There were no statistically significant differences among groups on pathology.ConclusionIntra-arterial Y90 + DEBIRI was safe and demonstrated enhanced antitumor activity in rabbit VX2 tumors. This combined approach warrants further investigation.

Published
2020

2. Yttrium-90 Radioembolization to the Prostate Gland: Proof of Concept in a Canine Model and Clinical Translation

Author

Mouli, Samdeep K., Raiter, Simone, Harris, Kathleen, Mylarapu, Amrutha, Burks, Malcolm, Li, Weiguo, Gordon, Andrew C., Khan, Ali, Matsumoto, Monica, Bailey, Keith L., Pasciak, Alexander S., Manupipatpong, Sasicha, Weiss, Clifford R., Casalino, David, Miller, Frank H., Gates, Vanessa L., Hohlastos, Elias, Lewandowski, Robert J., Kim, Dong-Hyun, Dreher, Matthew R., and Salem, Riad

Published
2021
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3. Multimodality Imaging of Ethiodized Oil-loaded Radiopaque Microspheres during Transarterial Embolization of Rabbits with VX2 Liver Tumors.

Author

Tacher, Vania, Duran, Rafael, Lin, MingDe, Sohn, Jae Ho, Sharma, Karun V, Wang, Zhijun, Chapiro, Julius, Gacchina Johnson, Carmen, Bhagat, Nikhil, Dreher, Matthew R, Schäfer, Dirk, Woods, David L, Lewis, Andrew L, Tang, Yiqing, Grass, Michael, Wood, Bradford J, and Geschwind, Jean-François

Subjects
Animals, Rabbits, Liver Neoplasms, Experimental, Ethiodized Oil, Contrast Media, Embolization, Therapeutic, Microspheres, Male, Cone-Beam Computed Tomography, Multidetector Computed Tomography, Multimodal Imaging, Biomedical Imaging, Liver Disease, Digestive Diseases, Medical and Health Sciences, Nuclear Medicine & Medical Imaging
Abstract

Purpose To assess the visibility of radiopaque microspheres during transarterial embolization (TAE) in the VX2 rabbit liver tumor model by using multimodality imaging, including single-snapshot radiography, cone-beam computed tomography (CT), multidetector CT, and micro-CT. Materials and Methods The study was approved by the institutional animal care and use committee. Fifteen VX2-tumor-bearing rabbits were assigned to three groups depending on the type of embolic agent injected: 70-150-μm radiopaque microspheres in saline (radiopaque microsphere group), 70-150-μm radiopaque microspheres in contrast material (radiopaque microsphere plus contrast material group), and 70-150-μm radiolucent microspheres in contrast material (nonradiopaque microsphere plus contrast material group). Rabbits were imaged with single-snapshot radiography, cone-beam CT, and multidetector CT. Three to 5 weeks after sacrifice, excised livers were imaged with micro-CT and histologic analysis was performed. The visibility of the embolic agent was assessed with all modalities before and after embolization by using a qualitative three-point scale score reading study and a quantitative assessment of the signal-to-noise ratio (SNR) change in various regions of interest, including the tumor and its feeding arteries. The Kruskal-Wallis test was used to compare the rabbit characteristics across groups, and the Wilcoxon signed rank test was used to compare SNR measurements before and after embolization. Results Radiopaque microspheres were qualitatively visualized within tumor feeding arteries and targeted tissue with all imaging modalities (P < .05), and their presence was confirmed with histologic examination. SNRs of radiopaque microsphere deposition increased after TAE on multidetector CT, cone-beam CT, and micro-CT images (P < .05). Similar results were obtained when contrast material was added to radiopaque microspheres, except for additional image attenuation due to tumor enhancement. For the group with nonradiopaque microspheres and contrast material, retained tumoral contrast remained qualitatively visible with all modalities except for micro-CT, which demonstrated soluble contrast material washout over time. Conclusion Radiopaque microspheres were visible with all imaging modalities and helped increase conspicuity of the tumor as well as its feeding arteries after TAE in a rabbit VX2 liver tumor model. (©) RSNA, 2015.

Published
2016

7. Characterization of a novel intrinsically radiopaque Drug-eluting Bead for image-guided therapy: DC Bead LUMI™

Author

Ashrafi, Koorosh, Tang, Yiqing, Britton, Hugh, Domenge, Orianne, Blino, Delphine, Bushby, Andrew J., Shuturminska, Kseniya, den Hartog, Mark, Radaelli, Alessandro, Negussie, Ayele H., Mikhail, Andrew S., Woods, David L., Krishnasamy, Venkatesh, Levy, Elliot B., Wood, Bradford J., Willis, Sean L., Dreher, Matthew R., and Lewis, Andrew L.

Published
2017
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14. Supplementary Video 2 from Overcoming Limitations in Nanoparticle Drug Delivery: Triggered, Intravascular Release to Improve Drug Penetration into Tumors

Author

Manzoor, Ashley A., primary, Lindner, Lars H., primary, Landon, Chelsea D., primary, Park, Ji-Young, primary, Simnick, Andrew J., primary, Dreher, Matthew R., primary, Das, Shiva, primary, Hanna, Gabi, primary, Park, Won, primary, Chilkoti, Ashutosh, primary, Koning, Gerben A., primary, ten Hagen, Timo L.M., primary, Needham, David, primary, and Dewhirst, Mark W., primary

Published
2023
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15. Data from Overcoming Limitations in Nanoparticle Drug Delivery: Triggered, Intravascular Release to Improve Drug Penetration into Tumors

Author

Manzoor, Ashley A., primary, Lindner, Lars H., primary, Landon, Chelsea D., primary, Park, Ji-Young, primary, Simnick, Andrew J., primary, Dreher, Matthew R., primary, Das, Shiva, primary, Hanna, Gabi, primary, Park, Won, primary, Chilkoti, Ashutosh, primary, Koning, Gerben A., primary, ten Hagen, Timo L.M., primary, Needham, David, primary, and Dewhirst, Mark W., primary

Published
2023
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16. Supplementary Video 1 from Overcoming Limitations in Nanoparticle Drug Delivery: Triggered, Intravascular Release to Improve Drug Penetration into Tumors

Author

Manzoor, Ashley A., primary, Lindner, Lars H., primary, Landon, Chelsea D., primary, Park, Ji-Young, primary, Simnick, Andrew J., primary, Dreher, Matthew R., primary, Das, Shiva, primary, Hanna, Gabi, primary, Park, Won, primary, Chilkoti, Ashutosh, primary, Koning, Gerben A., primary, ten Hagen, Timo L.M., primary, Needham, David, primary, and Dewhirst, Mark W., primary

Published
2023
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17. Supplementary Materials and Methods from Overcoming Limitations in Nanoparticle Drug Delivery: Triggered, Intravascular Release to Improve Drug Penetration into Tumors

Author

Manzoor, Ashley A., primary, Lindner, Lars H., primary, Landon, Chelsea D., primary, Park, Ji-Young, primary, Simnick, Andrew J., primary, Dreher, Matthew R., primary, Das, Shiva, primary, Hanna, Gabi, primary, Park, Won, primary, Chilkoti, Ashutosh, primary, Koning, Gerben A., primary, ten Hagen, Timo L.M., primary, Needham, David, primary, and Dewhirst, Mark W., primary

Published
2023
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38. Additional file 1 of Yttrium-90 radioembolization as a possible new treatment for brain cancer: proof of concept and safety analysis in a canine model

Author

Pasciak, Alexander S., Sasicha Manupipatpong, Hui, Ferdinand K., Gainsburg, Larry, Krimins, Rebecca, M. Christine Zink, Brayton, Cory F., Morris, Meaghan, Sage, Jaime, Donahue, Danielle R., Dreher, Matthew R., Kraitchman, Dara L., and Weiss, Clifford R.

Abstract

Additional file 1:. M&M findings on P5.

Published
2020
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39. Magnetic resonance imaging (MRI)-guided transurethral ultrasound therapy of the prostate: a preclinical study with radiological and pathological correlation using customised MRI-based moulds

Author

Partanen, Ari, Yerram, Nitin K., Trivedi, Hari, Dreher, Matthew R., Oila, Juha, Hoang, Anthony N., Volkin, Dmitry, Nix, Jeffrey, Turkbey, Baris, Bernardo, Marcelino, Haines, Diana C., Benjamin, Compton J., Linehan, Marston W., Choyke, Peter, Wood, Bradford J., Ehnholm, Gösta J., Venkatesan, Aradhana M., and Pinto, Peter A.

Published
2013
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