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798 results on '"Drebber, Uta"'

3. Erythrophagocytosis is not a reproducible finding in liver biopsies, and is not associated with clinical diagnosis of hemophagocytic lymphohistiocytosis

Author

Desai, Niyati, Kudose, Satoru, Remotti, Helen E., Del Portillo, Armando, Fazlollahi, Ladan, Lee, Michael J., Xiong, Yuqing, Moreira, Roger K., Salomao, Marcela, Fiel, Maria Isabel, Gonzalez, Raul S., Misdraji, Joseph, Gill, Ryan M., Hart, John, Kleiner, David E., Drebber, Uta, Bellizzi, Andrew M., and Lagana, Stephen M.

Published
2024
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8. Analysis of Expression and Regulation of AKR1C2 in HPV-Positive and -Negative Oropharyngeal Squamous Cell Carcinoma.

Author

Ziogas, Maria, Siefer, Oliver, Wuerdemann, Nora, Balaji, Harini, Gross, Elena, Drebber, Uta, Klussmann, Jens Peter, and Huebbers, Christian U.

Subjects
SQUAMOUS cell carcinoma, PAPILLOMAVIRUS diseases, RESEARCH funding, OROPHARYNGEAL cancer, HEAD & neck cancer, SEX distribution, OXIDATIVE stress, CANCER patients, REVERSE transcriptase polymerase chain reaction, AGE distribution, GENE expression, IMMUNOHISTOCHEMISTRY, CELL lines, OXIDOREDUCTASES, HISTOLOGICAL techniques, GENETIC mutation, OVERALL survival, DISEASE complications
Abstract

Simple Summary: Oropharyngeal Squamous Cell Carcinoma (OPSCC) represents a significant fraction of head and neck cancers, with a challenging five-year survival rate of only 50%. Key risk factors include tobacco and alcohol consumption and infection with human papillomavirus (HPV), particularly HPV16. Distinct biological differences exist between HPV-positive and HPV-negative OPSCC, including differences in mutation patterns and gene expression profiles. This study focuses on aldo-keto reductases (AKRs), specifically AKR1C2, which are involved in cellular stress management and detoxification processes, particularly in cisplatin-resistant tumors. This study investigates the role of AKR1C2 in HPV-positive OPSCC and its effect on patient outcomes. The findings indicate that increased levels of AKR1C2 are linked to unfavorable prognosis, particularly in male patients, while higher levels in female patients indicate a favorable prognosis. Head and Neck Squamous Cell Carcinoma (HNSCC), particularly Oropharyngeal Squamous Cell Carcinoma (OPSCC), is a major global health challenge due to its increasing incidence and high mortality rate. This study investigates the role of aldo-keto reductase 1C2 (AKR1C2) in OPSCC, focusing on its expression, correlation with Human Papillomavirus (HPV) status, oxidative stress status, and clinical outcomes, with an emphasis on sex-specific differences. We analyzed AKR1C2 expression using immunohistochemistry in formalin-fixed, paraffin-embedded tissue samples from 51 OPSCC patients. Additionally, we performed RT-qPCR in cultured HPV16-E6*I and HPV16-E6 overexpressing HEK293 cell lines (p53WT). Statistical analyses were performed to assess the correlation between AKR1C2 expression and patient data. Our results indicate a significant association between increased AKR1C2 expression and higher AJCC classification (p = 0.009) as well as positive HPV status (p = 0.008). Prognostic implications of AKR1C2 varied by sex, whereby female patients with high AKR1C2 expression had better overall survival, whereas male patients exhibited poorer outcomes. Additionally, AKR1C2 expression was linked to HPV status, suggesting a potential HPV-specific regulatory mechanism. These findings underscore the complex interplay among AKR1C2, HPV, and patient sex, highlighting the need for personalized treatment strategies for OPSCC. Targeted inhibition of AKR1C2, considering sex-specific differences, may enhance therapeutic outcomes. Future research should investigate these mechanisms to enhance treatment efficacy. [ABSTRACT FROM AUTHOR]

Published
2024
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10. Plasma Circulating Tumor DNA Sequencing Reveals the Landscape of Acquired Mutations in Patients with Hepatocellular Carcinoma: a Potential Predictive Value in Liquid Biopsy

Author

Wu, Xiaolin, primary, Borchmann, Sven, additional, Heger, Jan-Michel, additional, Kasper, Philipp, additional, Li, Jiahui, additional, Bamberger, Margaux, additional, Gassa, Asmae, additional, Alakus, Hakan, additional, Odenthal, Margarete, additional, Drebber, Uta, additional, Altmüller, Janine, additional, Becker, Kerstin, additional, Stippel, Dirk, additional, Bruns, Christiane J, additional, Zhao, Yue, additional, and Wahba, Roger, additional

Published
2024
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11. Akute und chronische Hepatitis

Author

Dienes, Hans Peter, Drebber, Uta, Remmele, Wolfgang, Founded by, Klöppel, Günter, Series Editor, Kreipe, Hans H., Series Editor, and Tannapfel, Andrea, editor

Published
2020
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12. Microwave ablation enhances tumor-specific immune response in patients with hepatocellular carcinoma

Author

Leuchte, Katharina, Staib, Elena, Thelen, Martin, Gödel, Philipp, Lechner, Axel, Zentis, Peter, Garcia-Marquez, Maria, Waldschmidt, Dirk, Datta, Rabi Raj, Wahba, Roger, Wybranski, Christian, Zander, Thomas, Quaas, Alexander, Drebber, Uta, Stippel, Dirk Ludger, Bruns, Christiane, von Bergwelt-Baildon, Michael, Wennhold, Kerstin, and Schlößer, Hans Anton

Published
2021
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19. Schistosoma mansoni eggs induce Wnt/β-catenin signaling and activate the protooncogene c-Jun in human and hamster colon

Author

Weglage, Jakob, Wolters, Friederike, Hehr, Laura, Lichtenberger, Jakob, Wulz, Celina, Hempel, Felix, Baier, Anne, Quack, Thomas, Köhler, Kernt, Longerich, Thomas, Schramm, Gabriele, Irungbam, Karuna, Mueller, Heike, von Buelow, Verena, Tschuschner, Annette, Odenthal, Margarete, Drebber, Uta, Arousy, Maha El, Ramalho, Leandra N. Z., Bankov, Katrin, Wild, Peter, Pons-Kühnemann, Jörn, Tschammer, Jonas, Grevelding, Christoph G., Roeb, Elke, and Roderfeld, Martin

Published
2020
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21. Development of a novel non-invasive test for prediction of liver fibrosis in patients with clinically severe obesity defined by a BMI over 50 kg/m²

Author

Brol, Maximilian Joseph, primary, Drebber, Uta, additional, Yu, Xiaojie, additional, Schierwagen, Robert, additional, Klein, Sabine, additional, Plamper, Andreas, additional, Odenthal, Margarete, additional, Gu, Wenyi, additional, Uschner, Frank Erhard, additional, Rheinwalt, Karl-Peter, additional, and Trebicka, Jonel, additional

Published
2023
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29. Stage of fibrosis is not a predictive determinant of weight loss in patients undergoing bariatric surgery

Author

Brol, MaximilianJoseph, additional, Drebber, Uta, additional, Yu, Xiaojie, additional, Schierwagen, Robert, additional, Gu, Wenyi, additional, Plamper, Andreas, additional, Klein, Sabine, additional, Odenthal, Margarete, additional, Uschner, FrankErhard, additional, Praktiknjo, Michael, additional, Trebicka, Jonel, additional, and Rheinwalt, KarlPeter, additional

Published
2023
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30. White-Light or Narrow-Band Imaging Colonoscopy in Surveillance of Ulcerative Colitis: A Prospective Multicenter Study

Author

Büttner, Reinhard, Löser, Heike, Drebber, Uta, Dignass, Axel, Terjung, Birgit, Sauerbruch, Tilman, Schreiber, Stefan, Lanyi, Barbara, Pfuetzer, Roland, Morgenstern, Julia, Böhm, Stephan, Böcker, Ulrich, Rupf, Ann-Kathrin, Appenroth, Beate, Biecker, Erwin, Walldorf, Jens, Leifeld, Ludger, Rogler, Gerhard, Stallmach, Andreas, Schmidt, Carsten, Zuber-Jerger, Ina, Hartmann, Franz, Plauth, Mathias, Drabik, Attyla, Hofstädter, Ferdinand, Dienes, Hans Peter, and Kruis, Wolfgang

Published
2015
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40. Lipid Droplet-Associated Proteins Perilipin 1 and 2: Molecular Markers of Steatosis and Microvesicular Steatotic Foci in Chronic Hepatitis C

Author

Schelbert, Selina, Schindeldecker, Mario, Drebber, Uta, Witzel, Hagen Roland, Weinmann, Arndt, Dries, Volker, Schirmacher, Peter, Roth, Wilfried, Straub, Beate Katharina, Schelbert, Selina, Schindeldecker, Mario, Drebber, Uta, Witzel, Hagen Roland, Weinmann, Arndt, Dries, Volker, Schirmacher, Peter, Roth, Wilfried, and Straub, Beate Katharina

Abstract

Chronic infection with hepatitis C (HCV) is a major risk factor in the development of cirrhosis and hepatocellular carcinoma. Lipid metabolism plays a major role in the replication and deposition of HCV at lipid droplets (LDs). We have demonstrated the importance of LD-associated proteins of the perilipin family in steatotic liver diseases. Using a large collection of 231 human liver biopsies with HCV, perilipins 1 and 2 have been localized to LDs of hepatocytes that correlate with the degree of steatosis and specific HCV genotypes, but not significantly with the HCV viral load. Perilipin 1- and 2-positive microvesicular steatotic foci were observed in 36% of HCV liver biopsies, and also in chronic hepatitis B, autoimmune hepatitis and mildly steatotic or normal livers, but less or none were observed in normal livers of younger patients. Microvesicular steatotic foci did not frequently overlap with glycogenotic/clear cell foci as determined by PAS stain in serial sections. Steatotic foci were detected in all liver zones with slight architectural disarrays, as demonstrated by immunohistochemical glutamine synthetase staining of zone three, but without elevated Ki67-proliferation rates. In conclusion, microvesicular steatotic foci are frequently found in chronic viral hepatitis, but the clinical significance of these foci is so far not clear.

Published
2022

41. Placental Invasion into the Small Bowel Intestine Through a Myomectomy Scar: A Case Report With Literature Review

Author

Saleh, Mohamed M., Mallmann, Michael R., Essakly, Ahlem, Drebber, Uta, Kleinert, Robert, Kuetting, Fabian, Bratke, Grischa, Mueller, Annette M., Saleh, Mohamed M., Mallmann, Michael R., Essakly, Ahlem, Drebber, Uta, Kleinert, Robert, Kuetting, Fabian, Bratke, Grischa, and Mueller, Annette M.

Abstract

Although extremely rare, uterine damage after hysteroscopic myomectomy sets the precondition for various life-threatening placental attachment disorders like placenta percreta (PP) or scar pregnancy. Due to vast clinical similarities, these terms are often used interchangeably. We report a case of a 47-yr-old patient at 27 wk + 4 d of gestation who presented with rectal bleeding. Clinical history revealed a previous uterine posterior wall myomectomy. The patient received intensive diagnostic work-up including sonography and magnetic resonance imaging. Under the suspicion of a bleeding Meckel diverticulum, an emergency laparotomy was performed. Intraoperatively it was observed that the placental tissue infiltrated the small bowel intestine at the location of the previous myomectomy. The adjacent intestine and the infiltrating placenta were surgically removed. The placenta could be easily detached from the uterus, which is why no hysterectomy was performed. Retrospectively, no radiologic or clinical hints of PP or scar pregnancy were evident before the surgery. Moreover, the pathologic work-up carried out afterwards proved no histopathologic evidence for PP. Our case underlines several clinical and pathologic difficulties. First, invasive placenta disorders including infiltration of intestinal organs have to be considered even after minor surgical interventions such as myomectomy. Second, clinical presentation is extremely variable and sometimes misleading, depending on the localization and the type of invasion. Our case underlines the importance of histopathologic work-up for distinguishing between various placenta attachment disorders such as PP and scar pregnancy. Given the large overlap in clinical presentation, pathophysiology and definition, we propose that the current definitions for PP and scar pregnancy have to be carefully reevaluated and broadened.

Published
2022

42. Kaposi sarcoma-a complication of treatment refractory ulcerative colitis

Author

Fischer, Anne Kristin, Kroesen, Anton, Buttner, Reinhard, Drebber, Uta, Fischer, Anne Kristin, Kroesen, Anton, Buttner, Reinhard, and Drebber, Uta

Abstract

We report on the incidental finding of Kaposi sarcoma of the colon in the setting of refractory ulcerative colitis treatment. The patient was under long-term immunosuppression with infliximab, vedolizumab, and prednisolone. Serologic analysis excluded human immunodeficiency virus (HIV) infection.

Published
2022

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