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1. Variability within the human TERT gene, telomere length and predisposition to chronic lymphocytic leukemia

Author

Wysoczanska B, Dratwa M, Gebura K, Mizgala J, Mazur G, Wrobel T, and Bogunia-Kubik K

Subjects
telomere length, human telomerase reverse transcriptase, variable number of tandem repeat, single nucleotide polymorphism, chronic lymphocytic leukaemia, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Barbara Wysoczanska,1 Marta Dratwa,1 Katarzyna Gebura,1 Jakub Mizgala,1 Grzegorz Mazur,2 Tomasz Wrobel,3 Katarzyna Bogunia-Kubik11Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw 53-114, Poland; 2Department of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology, Wroclaw Medical University, Wroclaw, 50-001, Poland; 3Department of Haematology, Blood Neoplasms and Bone Marrow Transplantation, Wroclaw Medical University, Wroclaw 50-367, PolandBackground: The human telomerase reverse transcriptase (TERT) gene encodes the catalytic subunit of telomerase that is essential for maintenance of telomere length. We aimed to find out whether variability within the TERT gene could be associated with telomere length and development of the disease in non-treated patients with chronic lymphocytic leukemia (CLL).Materials and methods: Telomere length, rs2736100, rs2853690, rs33954691, rs35033501 single-nucleotide polymorphisms, and variable number of tandem repeats (VNTR-MNS16A) were assessed in patients at diagnosis. In addition, blood donors served as controls for the polymorphism studies.Results: The minor rs35033501 A variant was more frequent among CLL patients than in healthy controls (OR=3.488, p=0.039). CLL patients over 60 years of age were characterized with lower disease stage at diagnosis (p=0.001 and p=0.008, for the Rai and Binet criteria, respectively). The MNS16A VNTR-243 short allele was more frequent in patients with a low disease stage (p=0.020 and p=0.028, for the Rai and Binet staging system) and also among older patients having longer telomeres (p=0.046). Patients with Rai 0–I stage were characterized with longer telomeres than those with more advanced disease (p=0.030). This relationship was especially pronounced in patients carrying the rs2736100 C allele, independently of the criteria used, ie, Binet (p=0.048) or Rai (p=0.001).Conclusion: Our results showed that the genetic variation within the TERT gene seems to play a regulatory role in CLL and telomere length.Keywords: telomere length, human telomerase reverse transcriptase, variable number of tandem repeats, single-nucleotide polymorphism, chronic lymphocytic leukemia

Published
2019

6. Erythropoietic response to oral iron in patients with nondialysis-dependent chronic kidney disease in the FIND-CKD trial

Author

Macdougall, I. C., Bock, A. H., Carrera, F., Eckardt, K. -U., Gaillard, C., Van Wyck, D., Meier, Y., Larroque, S., Perrin, A., Roger, S. D., Gilles, Auguste, Faull, R., Toussaint, N. D., Mcmahon, L., Suranyi, M., Mudge, D., Hutchison, B., Irish, A., Kerr, P., Kulkarni, H., Elder, G., Jardine, M., Lhotta, K., Mayer, G., Vanholder, R., Maes, B. D., Evenepoel, P., Debelle, F., Jadoul, M., Dratwa, M., Macel, I., Dunaj, M., Kvapil, M., Bucek, P., Rehorova, J., Hruby, A., Honova, V., Malanova, L., Lucak, M., Lecian, D., Jirovec, M., Vlasak, J., Rychlik, I., Surel, S., Kamper, A. -L., Ostergaard, O., Steffensen, G. K., Chenine, L., Choukroun, G., Zaoui, P., Wanner, C., Backs, W., Kraatz, U., Dellanna, F., Busch, K., Marsen, T., Seeger, W., Woitas, R., Obermueller, N., Haak, T., Lueders, S., Pistrosch, F., Mueller, E., Mertens, P. R., Sutermer, W., Grebe, S. -O., Hafezi-Rachti, S., Roeser, S., Tsakiris, D., Memmos, D., Vlachakos, D., Vargemezis, V., Stefanidis, I., Syrganis, C., Alivanis, P., Papadakis, I., Papagalanis, N., Andrikos, A., Goumenos, D., Siamopoulos, K., Gouva, C., Papadakis, G., Boletis, I., Tsimnadi-Spanoudaki, M., Stamatiades, D., Stamatelou, K., Moutafis, S., Locatelli, Federica, Santoro, A., Quarello, F., Remuzzi, G., Coppola, S., Mortellaro, R. F., Icardi, A., Colussi, G., Grotta, F. D., Lombardi, L., Gallieni, M., Villa, G., Grandaliano, Giuseppe, Huisman, S., Barendregt, J., Gregoor, P. J. H., Oien, C., Rutkowski, B., Malecki, R., Nowicki, M., Rutkowski, P., Marczewski, K., Mysliwiec, M., Sydor, A., Rysz, J., Rydzewski, A., Klinger, M., Wnuk, R., Kozminski, P., Nocon, A., Ciechanowski, K., Correia, P., Neves, F., Barata, J., Mircescu, G., Voiculescu, M., Gluhovschi, G., Mota, E., De Francisco, A. L. M., Torre, A., Herreros, A., Luno, J., Gruss, E., Martins, J., Valles, M., Pascual, J., Barany, P., Ambuehl, P. M., Erturk, S., Arici, M., Paydas, S., Soypacaci, Z., Camsari, T., Ustundag, S., Thomas, M. E., D'Souza, R. J., Taylor, J. E., Pritchard, N. R., Jeffery, R., Riley, S. G., Bhatnagar, D., Bhandari, S., Reaich, D., Stevens, P. E., El Kossi, M., Roe, S., Camilleri, B., Ahmed, A., Khwaja, A., Thompson, B., Banerjee, D., Nicholas, J., Hutchison, A., Borrows, R., and Groningen Kidney Center (GKC)

Subjects
0301 basic medicine, Male, 030232 urology & nephrology, Administration, Oral, Gastroenterology, oral, 0302 clinical medicine, DIALYSIS, nondialysis, Settore MED/14 - NEFROLOGIA, Erythropoiesis, SUCROSE, Aged, 80 and over, education.field_of_study, biology, Anemia, General Medicine, Iron deficiency, RANDOMIZED CONTROLLED-TRIAL, Middle Aged, Nephrology, Female, INTRAVENOUS FERRIC CARBOXYMALTOSE, Research Article, Adult, medicine.medical_specialty, Iron, Population, supplement, 03 medical and health sciences, Multicenter trial, Internal medicine, medicine, DEFICIENCY ANEMIA, Humans, Renal Insufficiency, Chronic, education, Aged, Transferrin saturation, business.industry, ferritin, hemoglobin, medicine.disease, Ferritin, 030104 developmental biology, biology.protein, Hemoglobin, business, Kidney disease
Abstract

Aims: To evaluate erythropoietic response rates to oral iron over time in iron-deficient anemic patients with nondialysis-dependent chronic kidney disease (ND-CKD). Materials and methods: FIND-CKD was a 1-year, randomized, multicenter trial of iron therapy in patients with ND-CKD, anemia, and iron deficiency, without erythropoiesis-stimulating agent (ESA) therapy. Patients with active infection or C-reactive protein > 20 mg/L were excluded. In this post-hoc analysis, response was defined as >= 1 g/dL increase in hemoglobin (Hb) from baseline, before initiation of alternative anemia therapy (i.e., ESA, transfusion, or intravenous iron). Results: 308 patients received oral iron (200 mg elemental iron/day). Mean (SD) Hb at baseline was 10.4 (0.7) g/dL. At week 4, Hb data were available from 292 patients without alternative anemia therapy: 63/292 (21.6%) showed a response. Among the 229 nonresponders at week 4, 48.8% showed a cumulative response on >= 1 occasion by week 52 (11.1%, 19.9%, 25.9%, and 28.7% had a response at weeks 8, 12, 24, and 52, respectively), and 27.9% had received alternative iron therapy by week 52. Baseline levels of Hb, ferritin, and transferrin saturation were lower in responders than in nonresponders. Neither concomitant medication nor adherence (as assessed by medication count) was substantially different between early responders and nonresponders. Conclusion: Four weeks after starting oral iron therapy, only 21.6% of anemic patients with ND-CKD and iron deficiency showed an Hb increase of at least 1 g/dL. Among early nonresponders

Published
2017

8. Effect of Cinacalcet on Cardiovascular Disease in Patients Undergoing Dialysis

Author

Chertow GM, Block GA, Correa-Rotter R, Drüeke TB, Floege J, Goodman WG, Herzog CA, Kubo Y, London GM, Mahaffey KW, Mix TC, Moe SM, Trotman ML, Wheeler DC, Parfrey PS., Evolve Team, Chertow G, Parfrey P, Block G, Drüeke T, Goodman W, Herzog C, London G, Mahaffey K, Moe S, Wheeler D, Hennekens C, Baigent C, Brown W, O'Brien P, Anderson S, Hoel J, Szczech L, Patel U, Wampole J, Pun P, Felker M, Inrig J, Shah S, Hernandez A, Patel C, Brennan M, Albizem M, Capper E, Cauchi L, Cheng S, Dehmel B, Dhami K, Durham C, Francioni M, Gadd S, Goodman B, Guimaraes L, Grey N, Hamlin R, Harris C, Harris E, Heavey S, Heiges T, Heiser D, Jaeger P, James M, James P, Karimi S, Kewalramani R, Kraszewski A, Liang J, Maguire J, McCormick K, McFarlane K, Mix C, Modafferi D, Prathikanti R, Ryan C, Santiago N, Schumacher J, Seder C, Shahinfar S, Soares B, Stolman D, Tisher C, Trotman M, Tseng S, Ulias G, Unger P, Vyshenskaya A, Walsh L, White C, Wilde K, Santos J, Zarazaga C, Marin I, Garrote N, Cusumano A, Penalba N, Del Valle E, Juncos L, Saye J, Lef L, Altobelli V, Petraglia G, Rosa-Diez G, Douthat W, Lobo J, Gallart C, Lafalla A, Diez G, Linares B, Lopez N, Ramirez N, Gonzalez R, Valtuille R, Beresan H, Hermida O, Rudolf G, Marchetta N, Rano M, Ramirez M, Garcia N, Gillies A, Jones B, Pedagogos E, Walker R, Talaulikar G, Bannister K, Suranyi M, Kark A, Roger S, Kerr P, Disney A, Mount P, Fraenkel M, Mathew M, Fassett R, Jose M, Hawley C, Lonergan M, Mackie J, Ferrari P, Menahem S, Sabto J, Hutchison B, Langham R, Pollock C, Holzer H, Oberbauer R, Arias I, Graf H, Mayer G, Lhotta K, Neyer U, Klauser-Braun R, Hoerl W, Horn S, Kovarik J, Kramar R, Eigner M, Dhaene M, Billiouw J, De Meester J, Warling X, Cambier-Dwelschauwers P, Evenepoel P, Daelemans R, Dratwa M, Maes B, Stolear J, Dejagere T, Vanwalleghem J, Bouman K, Jadoul M, Peeters J, Vanholder R, Tielemans C, Donck J, Almeida F, de Oliveira J, Burdmann E, Garcia V, Thome F, Deboni L, Bregman R, Lugon J, Araújo S, Ferreira Filho S, Daher Ede F, Baptista M, Carvalho A, d'Avila D, Moyses Neto M, Yu L, Bastos M, Lacativa P, Jorgetti V, Romão Ede A, da Costa JC, Pecoits Filho R, Gordan P, Salgado N, Araújo M, Coelho S, Oliveira I, Moysés R, Vasconcellos L, Batista P, Gross J, Pedrosa A, Cournoyer S, LeBlanc M, Chow S, Karunakaran S, Wong G, Tobe S, Desmeules S, Zimmerman D, Murphy S, Montambault P, Donnelly S, MacRae J, Culleton B, Soroka S, Rabbat C, Jindal K, Vasilevsky M, Michaud M, Wijeyesinghe E, Zacharias J, Lok C, Muirhead N, Verrelli M, Da Roza G, Sapir D, Olgaard K, Daugaard H, Brandi L, Jensen P, Boulechfar H, Ang K, Simon P, Rieu P, Brunet P, Touchard G, Torres P, Combe C, Durrbach A, Ortiz J, Hannedouche T, Vela C, Lionet A, Ryckelynck P, Zaoui P, Choukroun G, Fessi H, Lang P, Stroumza P, Joly D, Mousson C, Laville M, Dellanna F, Erley C, Braun J, Rambausek M, Riegel W, Klingberg M, Schwertfeger E, Wizemann V, Eckardt K, Reichel H, Passauer J, Hübel E, Frischmuth N, Liebl R, Fiedler R, Schwenger V, Voßkühler A, Kunzendorf U, Renders L, Rattensberger D, Rump L, Ketteler M, Neumayer H, Zantvoort F, Stahl R, Ladanyi E, Braun B, Kulcsar I, Mezei I, Csiky B, Rikker C, Arkossy O, Berta K, Szegedi J, Major L, Ferenczi S, Fekete A, Szabo T, Zakar G, Wagner G, Erdelyine S, Borbas B, Eustace J, Reddan D, Capasso G, Locatelli F, Villa G, Cozzolino M, Brancaccio D, Messa P, Bolasco P, Ricciardi B, Malberti F, Moriero E, Cannella G, Ortalda V, Stefoni S, Frascà G, Cappelli G, Albertazzi A, Zoccali C, Farina M, Elli A, Avella F, Ondei P, Mingardi G, Errico R, Losito A, Di Giulio S, Pertosa G, Schena F, Grandaliano G, Gesualdo L, Auricchio M, Bochicchio-Ricardelli T, Correa-Rotter J, Verástegui F, Peña J, Wong A, Cruz-Valdez J, Zamora M, Solis M, Diaz M, Flores M, Sandoval E, van den Dorpel M, Brink H, Van Kuijk W, Vermeij C, Gregoor P, Hagen E, van der Sande F, Klinger M, Nowicki M, Muszytowski M, Bidas K, Bentkowski W, Wiecek A, Ksiazek A, Marczewski K, Ostrowski M, Switalski M, Sulowicz W, Matuszkiewicz-Rowinska J, Mysliwiec M, Durlik M, Rutkowski B, Macario F, Carvalho B, Frazao J, Machado D, Weigert A, Andrusev A, Khrustalev O, Zemtchenkov A, Gurevich K, Staroselsky K, Khadikova N, Rozhinskaya L, Timokhovskaya G, Strokov A, Balkarova O, Ermolenko V, Kolmakova E, Komandenko M, Timofeev M, Shilo V, Shostka G, Smirnov A, Anashkin V, Volgina G, Domashenko O, Gurevich A, Perlin D, García J, Ribes E, Piera E, Lucas M, Galicia M, Prados M, González M, Romero R, de Francisco ÁM, Montenegro J, Santiago C, García F, de La Ossa J, Arrieta J, Pons J, Martín-Malo A, Amigó J, Cases A, Sterner G, Jensen G, Wikström B, Jacobson S, Lund U, Weiss L, Ståhl A, von Albertini B, Burnier M, Meier P, Martin P, Uehlinger D, Dickenmann M, Yaqoob M, Zehnder D, Kalra P, Padmanabhan N, Roe S, Eadington D, Pritchard N, Hutchison A, Davies S, Wilkie M, Davies M, Pai P, Swift P, Kwan J, Goldsmith D, Tomson C, Stratton J, Dasgupta I, Sarkar S, Moustafa M, Gandhi K, Jamal A, Galindo-Ramos E, Tuazon J, Batlle D, Tucker K, Schiller-Moran B, Assefi A, Martinez C, Samuels L, Goldman J, Cangiano-Rivera J, Darwish R, Lee M, Topf J, Kapatkin K, Baer H, Kopelman R, Acharya M, Tharpe D, Bernardo M, Nader P, Guzman-Rivera J, Pergola P, Sekkarie M, Alas E, Zager P, Liss K, Navarro J, Roppolo M, Denu-Ciocca C, Kshirsagar A, El Khatib M, Kant K, Scott D, Murthyr B, Finkelstein F, Keightley G, McCrary R, Pitone J, Cavalieri T, Tsang A, Pellegrino B, Schmidt R, Ahmad S, Brown C, Friedman E, Mittman N, Fadem S, Shapiro W, Reddy M, Goldberger S, Woredekal Y, Agarwal A, Anger M, Haque M, Chidester P, Kohli R, Rubinstein S, Newman G, Gladish R, Ayodeji O, Soman S, Sprague S, Hunt N, Gehr T, Rizk D, Warnock D, Polack D, Pahl M, Fischer D, Dreyer P, James G, Husserl F, Rogers T, Raff A, Sedor J, Silver M, Smith M, Steinberg S, DelGiorno T, Jones E, Cunha P, Cheng J, Pogue V, Blumenthal S, Brown E, Charytan C, Buerkert J, Cook M, Felsenfeld A, Tareen N, Gupta A, Herman T, Diamond S, Hura C, Laski M, MacLaurin J, Plumb T, Brosnahan G, Kumar J, Henriquez M, Poole C, Osanloo E, Matalon A, Sholer C, Arfeen S, Azer M, Belledonne M, Gross M, Dunnigan E, McConnell K, Becker B, Rigolosi R, Spiegel D, Stegman M, Patak R, Streja D, Ranjit U, Youell T, Wooldridge T, Stafford C, Cottiero R, Weinberg M, Schonefeld M, Shahmir E, Hazzan A, Ashfaq A, Bhandari K, Cleveland W, Culpepper M, Golden J, Lai L, Lien Y, Lorica V, Robertson J, Malireddi K, Morse S, Thakur V, Israelit A, Raguram P, Alfred H, Weise W, Al-Saghir F, El Shahawy M, Rastogi A, Nissenson A, Kopyt N, Lynn R, Lea J, McClellan W, Teredesai P, Ong S, Tolkan S, Sugihara J, Minga T, Mehrotra R, Minasian R, Bhatia D, Specter R, Capelli J, Sidhu P, Dalal S, Dykes P, Khan M, Rahim F, Saklayen M, Thomas A, Michael B, Torres M, Al-Bander H, Murray B, Abukurah A, Gupta B, Nosrati S, Raja R, Zeig S, Braun M, Amatya A, Endsley J, Sharon Z, Dolson G, Dumler F, Ntoso K, Rosansky S, Kumar N, Gura V, Thompson N, Goldfarb D, Halligan R, Middleton J, Widerhorn A, Arbeit L, Arruda J, Crouch T, Friedman L, Khokhar S, Mittleman J, Light P, Taparia B, West C, Cotton J, Dhingra R, Kleinman L, Arif F, Lew S, Nammour T, Sterrett J, Williams M, Ramirez J, Rubin J, McCarthy J, Noble S, Chaffin M, Rekhi A., Chertow, Gm, Block, Ga, Correa-Rotter, R, Drüeke, Tb, Floege, J, Goodman, Wg, Herzog, Ca, Kubo, Y, London, Gm, Mahaffey, Kw, Mix, Tc, Moe, Sm, Trotman, Ml, Wheeler, Dc, Parfrey, Ps., Evolve, Team, Chertow, G, Parfrey, P, Block, G, Drüeke, T, Goodman, W, Herzog, C, London, G, Mahaffey, K, Moe, S, Wheeler, D, Hennekens, C, Baigent, C, Brown, W, O'Brien, P, Anderson, S, Hoel, J, Szczech, L, Patel, U, Wampole, J, Pun, P, Felker, M, Inrig, J, Shah, S, Hernandez, A, Patel, C, Brennan, M, Albizem, M, Capper, E, Cauchi, L, Cheng, S, Dehmel, B, Dhami, K, Durham, C, Francioni, M, Gadd, S, Goodman, B, Guimaraes, L, Grey, N, Hamlin, R, Harris, C, Harris, E, Heavey, S, Heiges, T, Heiser, D, Jaeger, P, James, M, James, P, Karimi, S, Kewalramani, R, Kraszewski, A, Liang, J, Maguire, J, Mccormick, K, Mcfarlane, K, Mix, C, Modafferi, D, Prathikanti, R, Ryan, C, Santiago, N, Schumacher, J, Seder, C, Shahinfar, S, Soares, B, Stolman, D, Tisher, C, Trotman, M, Tseng, S, Ulias, G, Unger, P, Vyshenskaya, A, Walsh, L, White, C, Wilde, K, Santos, J, Zarazaga, C, Marin, I, Garrote, N, Cusumano, A, Penalba, N, Del Valle, E, Juncos, L, Saye, J, Lef, L, Altobelli, V, Petraglia, G, Rosa-Diez, G, Douthat, W, Lobo, J, Gallart, C, Lafalla, A, Diez, G, Linares, B, Lopez, N, Ramirez, N, Gonzalez, R, Valtuille, R, Beresan, H, Hermida, O, Rudolf, G, Marchetta, N, Rano, M, Ramirez, M, Garcia, N, Gillies, A, Jones, B, Pedagogos, E, Walker, R, Talaulikar, G, Bannister, K, Suranyi, M, Kark, A, Roger, S, Kerr, P, Disney, A, Mount, P, Fraenkel, M, Mathew, M, Fassett, R, Jose, M, Hawley, C, Lonergan, M, Mackie, J, Ferrari, P, Menahem, S, Sabto, J, Hutchison, B, Langham, R, Pollock, C, Holzer, H, Oberbauer, R, Arias, I, Graf, H, Mayer, G, Lhotta, K, Neyer, U, Klauser-Braun, R, Hoerl, W, Horn, S, Kovarik, J, Kramar, R, Eigner, M, Dhaene, M, Billiouw, J, De Meester, J, Warling, X, Cambier-Dwelschauwers, P, Evenepoel, P, Daelemans, R, Dratwa, M, Maes, B, Stolear, J, Dejagere, T, Vanwalleghem, J, Bouman, K, Jadoul, M, Peeters, J, Vanholder, R, Tielemans, C, Donck, J, Almeida, F, de Oliveira, J, Burdmann, E, Garcia, V, Thome, F, Deboni, L, Bregman, R, Lugon, J, Araújo, S, Ferreira Filho, S, Daher Ede, F, Baptista, M, Carvalho, A, D'Avila, D, Moyses Neto, M, Yu, L, Bastos, M, Lacativa, P, Jorgetti, V, Romão Ede, A, da Costa, Jc, Pecoits Filho, R, Gordan, P, Salgado, N, Araújo, M, Coelho, S, Oliveira, I, Moysés, R, Vasconcellos, L, Batista, P, Gross, J, Pedrosa, A, Cournoyer, S, Leblanc, M, Chow, S, Karunakaran, S, Wong, G, Tobe, S, Desmeules, S, Zimmerman, D, Murphy, S, Montambault, P, Donnelly, S, Macrae, J, Culleton, B, Soroka, S, Rabbat, C, Jindal, K, Vasilevsky, M, Michaud, M, Wijeyesinghe, E, Zacharias, J, Lok, C, Muirhead, N, Verrelli, M, Da Roza, G, Sapir, D, Olgaard, K, Daugaard, H, Brandi, L, Jensen, P, Boulechfar, H, Ang, K, Simon, P, Rieu, P, Brunet, P, Touchard, G, Torres, P, Combe, C, Durrbach, A, Ortiz, J, Hannedouche, T, Vela, C, Lionet, A, Ryckelynck, P, Zaoui, P, Choukroun, G, Fessi, H, Lang, P, Stroumza, P, Joly, D, Mousson, C, Laville, M, Dellanna, F, Erley, C, Braun, J, Rambausek, M, Riegel, W, Klingberg, M, Schwertfeger, E, Wizemann, V, Eckardt, K, Reichel, H, Passauer, J, Hübel, E, Frischmuth, N, Liebl, R, Fiedler, R, Schwenger, V, Voßkühler, A, Kunzendorf, U, Renders, L, Rattensberger, D, Rump, L, Ketteler, M, Neumayer, H, Zantvoort, F, Stahl, R, Ladanyi, E, Braun, B, Kulcsar, I, Mezei, I, Csiky, B, Rikker, C, Arkossy, O, Berta, K, Szegedi, J, Major, L, Ferenczi, S, Fekete, A, Szabo, T, Zakar, G, Wagner, G, Erdelyine, S, Borbas, B, Eustace, J, Reddan, D, Capasso, G, Locatelli, F, Villa, G, Cozzolino, M, Brancaccio, D, Messa, P, Bolasco, P, Ricciardi, B, Malberti, F, Moriero, E, Cannella, G, Ortalda, V, Stefoni, S, Frascà, G, Cappelli, G, Albertazzi, A, Zoccali, C, Farina, M, Elli, A, Avella, F, Ondei, P, Mingardi, G, Errico, R, Losito, A, Di Giulio, S, Pertosa, G, Schena, F, Grandaliano, G, Gesualdo, L, Auricchio, M, Bochicchio-Ricardelli, T, Correa-Rotter, J, Verástegui, F, Peña, J, Wong, A, Cruz-Valdez, J, Zamora, M, Solis, M, Diaz, M, Flores, M, Sandoval, E, van den Dorpel, M, Brink, H, Van Kuijk, W, Vermeij, C, Gregoor, P, Hagen, E, van der Sande, F, Klinger, M, Nowicki, M, Muszytowski, M, Bidas, K, Bentkowski, W, Wiecek, A, Ksiazek, A, Marczewski, K, Ostrowski, M, Switalski, M, Sulowicz, W, Matuszkiewicz-Rowinska, J, Mysliwiec, M, Durlik, M, Rutkowski, B, Macario, F, Carvalho, B, Frazao, J, Machado, D, Weigert, A, Andrusev, A, Khrustalev, O, Zemtchenkov, A, Gurevich, K, Staroselsky, K, Khadikova, N, Rozhinskaya, L, Timokhovskaya, G, Strokov, A, Balkarova, O, Ermolenko, V, Kolmakova, E, Komandenko, M, Timofeev, M, Shilo, V, Shostka, G, Smirnov, A, Anashkin, V, Volgina, G, Domashenko, O, Gurevich, A, Perlin, D, García, J, Ribes, E, Piera, E, Lucas, M, Galicia, M, Prados, M, González, M, Romero, R, de Francisco, Ám, Montenegro, J, Santiago, C, García, F, de La Ossa, J, Arrieta, J, Pons, J, Martín-Malo, A, Amigó, J, Cases, A, Sterner, G, Jensen, G, Wikström, B, Jacobson, S, Lund, U, Weiss, L, Ståhl, A, von Albertini, B, Burnier, M, Meier, P, Martin, P, Uehlinger, D, Dickenmann, M, Yaqoob, M, Zehnder, D, Kalra, P, Padmanabhan, N, Roe, S, Eadington, D, Pritchard, N, Hutchison, A, Davies, S, Wilkie, M, Davies, M, Pai, P, Swift, P, Kwan, J, Goldsmith, D, Tomson, C, Stratton, J, Dasgupta, I, Sarkar, S, Moustafa, M, Gandhi, K, Jamal, A, Galindo-Ramos, E, Tuazon, J, Batlle, D, Tucker, K, Schiller-Moran, B, Assefi, A, Martinez, C, Samuels, L, Goldman, J, Cangiano-Rivera, J, Darwish, R, Lee, M, Topf, J, Kapatkin, K, Baer, H, Kopelman, R, Acharya, M, Tharpe, D, Bernardo, M, Nader, P, Guzman-Rivera, J, Pergola, P, Sekkarie, M, Alas, E, Zager, P, Liss, K, Navarro, J, Roppolo, M, Denu-Ciocca, C, Kshirsagar, A, El Khatib, M, Kant, K, Scott, D, Murthyr, B, Finkelstein, F, Keightley, G, Mccrary, R, Pitone, J, Cavalieri, T, Tsang, A, Pellegrino, B, Schmidt, R, Ahmad, S, Brown, C, Friedman, E, Mittman, N, Fadem, S, Shapiro, W, Reddy, M, Goldberger, S, Woredekal, Y, Agarwal, A, Anger, M, Haque, M, Chidester, P, Kohli, R, Rubinstein, S, Newman, G, Gladish, R, Ayodeji, O, Soman, S, Sprague, S, Hunt, N, Gehr, T, Rizk, D, Warnock, D, Polack, D, Pahl, M, Fischer, D, Dreyer, P, James, G, Husserl, F, Rogers, T, Raff, A, Sedor, J, Silver, M, Smith, M, Steinberg, S, Delgiorno, T, Jones, E, Cunha, P, Cheng, J, Pogue, V, Blumenthal, S, Brown, E, Charytan, C, Buerkert, J, Cook, M, Felsenfeld, A, Tareen, N, Gupta, A, Herman, T, Diamond, S, Hura, C, Laski, M, Maclaurin, J, Plumb, T, Brosnahan, G, Kumar, J, Henriquez, M, Poole, C, Osanloo, E, Matalon, A, Sholer, C, Arfeen, S, Azer, M, Belledonne, M, Gross, M, Dunnigan, E, Mcconnell, K, Becker, B, Rigolosi, R, Spiegel, D, Stegman, M, Patak, R, Streja, D, Ranjit, U, Youell, T, Wooldridge, T, Stafford, C, Cottiero, R, Weinberg, M, Schonefeld, M, Shahmir, E, Hazzan, A, Ashfaq, A, Bhandari, K, Cleveland, W, Culpepper, M, Golden, J, Lai, L, Lien, Y, Lorica, V, Robertson, J, Malireddi, K, Morse, S, Thakur, V, Israelit, A, Raguram, P, Alfred, H, Weise, W, Al-Saghir, F, El Shahawy, M, Rastogi, A, Nissenson, A, Kopyt, N, Lynn, R, Lea, J, Mcclellan, W, Teredesai, P, Ong, S, Tolkan, S, Sugihara, J, Minga, T, Mehrotra, R, Minasian, R, Bhatia, D, Specter, R, Capelli, J, Sidhu, P, Dalal, S, Dykes, P, Khan, M, Rahim, F, Saklayen, M, Thomas, A, Michael, B, Torres, M, Al-Bander, H, Murray, B, Abukurah, A, Gupta, B, Nosrati, S, Raja, R, Zeig, S, Braun, M, Amatya, A, Endsley, J, Sharon, Z, Dolson, G, Dumler, F, Ntoso, K, Rosansky, S, Kumar, N, Gura, V, Thompson, N, Goldfarb, D, Halligan, R, Middleton, J, Widerhorn, A, Arbeit, L, Arruda, J, Crouch, T, Friedman, L, Khokhar, S, Mittleman, J, Light, P, Taparia, B, West, C, Cotton, J, Dhingra, R, Kleinman, L, Arif, F, Lew, S, Nammour, T, Sterrett, J, Williams, M, Ramirez, J, Rubin, J, Mccarthy, J, Noble, S, Chaffin, M, and Rekhi, A.

Subjects
Adult, Male, Dialysis, Cinacalcet, Cardiovascular Disease, medicine.medical_specialty, Calcimimetic, medicine.medical_treatment, Naphthalenes, Coronary artery disease, Renal Dialysis, Internal medicine, Odds Ratio, medicine, Humans, Intensive care medicine, Aged, Etelcalcetide, Hyperparathyroidism, Hypocalcemia, business.industry, General Medicine, Middle Aged, medicine.disease, Intention to Treat Analysis, Cardiovascular Diseases, Parathyroid Hormone, Cinacalcet Hydrochloride, Kidney Failure, Chronic, Female, Hyperparathyroidism, Secondary, Secondary hyperparathyroidism, business, medicine.drug
Abstract

Disorders of mineral metabolism, including secondary hyperparathyroidism, are thought to contribute to extraskeletal (including vascular) calcification among patients with chronic kidney disease. It has been hypothesized that treatment with the calcimimetic agent cinacalcet might reduce the risk of death or nonfatal cardiovascular events in such patients.In this clinical trial, we randomly assigned 3883 patients with moderate-to-severe secondary hyperparathyroidism (median level of intact parathyroid hormone, 693 pg per milliliter [10th to 90th percentile, 363 to 1694]) who were undergoing hemodialysis to receive either cinacalcet or placebo. All patients were eligible to receive conventional therapy, including phosphate binders, vitamin D sterols, or both. The patients were followed for up to 64 months. The primary composite end point was the time until death, myocardial infarction, hospitalization for unstable angina, heart failure, or a peripheral vascular event. The primary analysis was performed on the basis of the intention-to-treat principle.The median duration of study-drug exposure was 21.2 months in the cinacalcet group, versus 17.5 months in the placebo group. The primary composite end point was reached in 938 of 1948 patients (48.2%) in the cinacalcet group and 952 of 1935 patients (49.2%) in the placebo group (relative hazard in the cinacalcet group vs. the placebo group, 0.93; 95% confidence interval, 0.85 to 1.02; P=0.11). Hypocalcemia and gastrointestinal adverse events were significantly more frequent in patients receiving cinacalcet.In an unadjusted intention-to-treat analysis, cinacalcet did not significantly reduce the risk of death or major cardiovascular events in patients with moderate-to-severe secondary hyperparathyroidism who were undergoing dialysis. (Funded by Amgen; EVOLVE ClinicalTrials.gov number, NCT00345839.).

Published
2012

9. Pharmacokinetics of rilmenidine in patients with chronic renal insufficiency and in hemodialysis patients

Author

Aparicio, A., Dratwa, M., Esper, N. El, Fillastre, J.P., Levaltier, B., Lins, R., Meyrier, A., Mignon, F., Ryckelnyck, J.P., and Sennesael, J.

Subjects
Rilmenidine -- Physiological aspects, Chronic kidney failure -- Drug therapy, Hemodialysis patients -- Health aspects, Health
Abstract

The pharmacokinetics of rilmenidine (1 mg orally) was studied in 3 groups of patients with stable chronic renal insufficiency. This was an open, single-blind study following a single administration, and after 15 days of treatment. Group 1 included 11 patients with a creatinine clearance between 15 and 80 mL/min. Group 2 included 17 patients with a creatinine clearance

Published
1994

11. Cinacalcet, fibroblast growth factor-23, and cardiovascular disease in hemodialysis: The evaluation of cinacalcet HCl therapy to lower cardiovascular events (EVOLVE) trial

Author

Moe S. M., Chertow G. M., Parfrey P. S., Kubo Y., Block G. A., Correa-Rotter R., Drueke T. B., Herzog C. A., London G. M., Mahaffey K. W., Wheeler D. C., Stolina M., Dehmel B., Goodman W. G., Floege J., Santos J., Najun Zarazaga C., Marin I., Garrote N., Cusumano A., Penalba N., Del Valle E., Juncos L., Martinez Saye J., Lef L., Altobelli V., Petraglia G., Rosa Diez G., Douthat W., Lobo J., Gallart C., Lafalla A., Diez G., Linares B., Lopez N., Ramirez N., Gonzalez R., Valtuille R., Beresan H., Hermida O., Rudolf G., Marchetta N., Rano M., Ramirez M., Garcia N., Gillies A., Jones B., Pedagogos E., Walker R., Talaulikar G., Bannister K., Suranyi M., Kark A., Roger S., Kerr P., Disney A., Mount P., Fraenkel M., Mathew M., Fassett R., Jose M., Hawley C., Lonergan M., Mackie J., Ferrari P., Menahem S., Sabto J., Hutchison B., Langham R., Pollock C., Holzer H., Oberbauer R., Arias I., Graf H., Mayer G., Lhotta K., Neyer U., Klauser R., Hoerl W., Horn S., Kovarik J., Kramar R., Eigner M., Dhaene M., Billiouw J., De Meester J., Warling X., Cambier-Dwelschauwers P., Evenepoel P., Daelemans R., Dratwa M., Maes B., Stolear J., Dejagere T., Vanwalleghem J., Bouman K., Jadoul M., Peeters J., Vanholder R., Tielemans C., Donck J., Almeida F., Picollo De Oliveira J., Burdmann E., Garcia V., Saldanha Thome F., Deboni L., Bregman R., Lugon J., Araujo S., Ferreira Filho S., De Francesco Daher E., Sperto Baptista M., Carvalho A., D'Avila D., Moyses Neto M., Yu L., Bastos M., Sampaio Lacativa P., Jorgetti V., De Almeida Romao E., Cardeal Da Costa J., Pecoits Filho R., Gordan P., Salgado N., Teixeira Araujo M., Neiva Coelho S., Oliveira I., Moyses R., Vasconcellos L., Batista P., Luiz Gross J., Pedrosa A., Cournoyer S., LeBlanc M., Chow S., Karunakaran S., Wong G., Tobe S., Desmeules S., Zimmerman D., Murphy S., Montambault P., Donnelly S., MacRae J., Culleton B., Soroka S., Rabbat C., Jindal K., Vasilevsky M., Michaud M., Wijeyesinghe E., Zacharias J., Lok C., Muirhead N., Verrelli M., Da Roza G., Sapir D., Olgaard K., Daugaard H., Brandi L., Jensen P., Boulechfar H., Ang K., Simon P., Rieu P., Brunet P., Touchard G., Urena Torres P., Combe C., Durrbach A., Ortiz J., Hannedouche T., Vela C., Lionet A., Ryckelynck P., Zaoui P., Choukroun G., Fessi H., Lang P., Stroumza P., Joly D., Mousson C., Laville M., Dellanna F., Erley C., Braun J., Rambausek M., Riegel W., Klingberg M., Schwertfeger E., Wizemann V., Eckardt K., Reichel H., Passauer J., Hubel E., Frischmuth N., Liebl R., Fiedler R., Schwenger V., Vosskuhler A., Kunzendorf U., Renders L., Rattensberger D., Rump L., Ketteler M., Neumayer H., Zantvoort F., Stahl R., Ladanyi E., Kulcsar I., Mezei I., Csiky B., Rikker C., Arkossy O., Berta K., Szegedi J., Major L., Ferenczi S., Fekete A., Szabo T., Zakar G., Wagner G., Kazup Erdelyine S., Borbas B., Eustace J., Reddan D., Capasso G., Locatelli F., Villa G., Cozzolino M., Brancaccio D., Messa P., Bolasco P., Ricciardi B., Malberti F., Moriero E., Cannella G., Ortalda V., Stefoni S., Frasca G., Cappelli G., Albertazzi A., Zoccali C., Farina M., Elli A., Avella F., Ondei P., Mingardi G., Errico R., Losito A., Di Giulio S., Pertosa G., Schena F., Grandaliano G., Gesualdo L., Auricchio M., Bochicchio-Ricardelli T., Aranda Verastegui F., Pena J., Chew Wong A., Cruz-Valdez J., Torres Zamora M., Solis M., Sebastian Diaz M., Vital Flores M., Alvarez Sandoval E., Van Den Dorpel M., Brink H., Van Kuijk W., Vermeij C., Smak Gregoor P., Hagen E., Van Der Sande F., Klinger M., Nowicki M., Muszytowski M., Bidas K., Bentkowski W., Wiecek A., Ksiazek A., Marczewski K., Ostrowski M., Switalski M., Sulowicz W., Matuszkiewicz-Rowinska J., Mysliwiec M., Durlik M., Rutkowski B., Macario F., Carvalho B., Frazao J., Machado D., Weigert A., Andrusev A., Khrustalev O., Zemtchenkov A., Gurevich K., Staroselsky K., Khadikova N., Rozhinskaya L., Timokhovskaya G., Strokov A., Balkarova O., Ermolenko V., Kolmakova E., Komandenko M., Timofeev M., Shilo V., Shostka G., Smirnov A., Anashkin V., Volgina G., Domashenko O., Gurevich A., Perlin D., Martinez Garcia J., Andres Ribes E., Coll Piera E., Fernandez Lucas M., Galicia M., Prados M., Gonzalez M., Romero R., Martin de Francisco A., Montenegro J., Santiago C., Garcia F., Alcazar De La Ossa J., Arrieta J., Pons J., Martin-Malo A., Soler Amigo J., Cases A., Sterner G., Jensen G., Wikstrom B., Jacobson S., Lund U., Weiss L., Stahl A., Von Albertini B., Burnier M., Meier P., Martin P., Uehlinger D., Dickenmann M., Yaqoob M., Zehnder D., Kalra P., Padmanabhan N., Roe S., Eadington D., Pritchard N., Hutchison A., Davies S., Wilkie M., Davies M., Pai P., Swift P., Kwan J., Goldsmith D., Tomson C., Stratton J., Dasgupta I., Sarkar S., Moustafa M., Gandhi K., Jamal A., Galindo-Ramos E., Tuazon J., Batlle D., Tucker K., Schiller-Moran B., Assefi A., Martinez C., Samuels L., Goldman J., Cangiano-Rivera J., Darwish R., Lee M., Topf J., Kapatkin K., Baer H., Kopelman R., Acharya M., Tharpe D., Bernardo M., Nader P., Guzman-Rivera J., Pergola P., Sekkarie M., Alas E., Zager P., Liss K., Navarro J., Roppolo M., Denu-Ciocca C., Kshirsagar A., El Khatib M., Kant K., Scott D., Murthyr B., Finkelstein F., Keightley G., McCrary R., Pitone J., Cavalieri T., Tsang A., Pellegrino B., Schmidt R., Ahmad S., Brown C., Friedman E., Mittman N., Fadem S., Shapiro W., Reddy M., Goldberger S., Woredekal Y., Agarwal A., Anger M., Haque M., Chidester P., Kohli R., Rubinstein S., Newman G., Gladish R., Ayodeji O., Soman S., Sprague S., Hunt N., Gehr T., Rizk D., Warnock D., Polack D., Pahl M., Fischer D., Dreyer P., James G., Husserl F., Rogers T., Raff A., Sedor J., Silver M., Smith M., Steinberg S., DelGiorno T., Jones E., Cunha P. D., Cheng J., Pogue V., Blumenthal S., Brown E., Charytan C., Buerkert J., Cook M., Felsenfeld A., Tareen N., Gupta A., Herman T., Diamond S., Hura C., Laski M., MacLaurin J., Plumb T., Brosnahan G., Kumar J., Henriquez M., Poole C., Osanloo E., Matalon A., Sholer C., Arfeen S., Azer M., Belledonne M., Gross M., Dunnigan E., McConnell K., Becker B., Skinner F., Rigolosi R., Spiegel D., Stegman M., Patak R., Streja D., Ranjit U., Youell T., Wooldridge T., Stafford C., Cottiero R., Weinberg M., Schonefeld M., Shahmir E., Hazzan A., Ashfaq A., Bhandari K., Cleveland W., Culpepper M., Golden J., Lai L., Lien Y., Lorica V., Robertson J., Malireddi K., Morse S., Thakur V., Israelit A., Raguram P., Alfred H., Weise W., Al-Saghir F., El Shahawy M., Rastogi A., Nissenson A., Kopyt N., Lynn R., Lea J., McClellan W., Teredesai P., Ong S., Tolkan S., Sugihara J., Minga T., Mehrotra R., Minasian R., Bhatia D., Specter R., Capelli J., Sidhu P., Dalal S., Dykes P., Khan M., Rahim F., Saklayen M., Thomas A., Michael B., Torres M., Al-Bander H., Murray B., Abukurah A., Gupta B., Nosrati S., Raja R., Zeig S., Braun M., Amatya A., Endsley J., Sharon Z., Dolson G., Dumler F., Ntoso K., Rosansky S., Kumar N., Gura V., Thompson N., Goldfarb D., Halligan R., Middleton J., Widerhorn A., Arbeit L., Arruda J., Crouch T., Friedman L., Khokhar S., Mittleman J., Light P., Taparia B., West C., Cotton J., Dhingra R., Kleinman L., Arif F., Lew S., Nammour T., Sterrett J., Williams M., Ramirez J., Rubin J., McCarthy J., Noble S., Chaffin M., Rekhi A., Moe, S. M., Chertow, G. M., Parfrey, P. S., Kubo, Y., Block, G. A., Correa-Rotter, R., Drueke, T. B., Herzog, C. A., London, G. M., Mahaffey, K. W., Wheeler, D. C., Stolina, M., Dehmel, B., Goodman, W. G., Floege, J., Santos, J., Najun Zarazaga, C., Marin, I., Garrote, N., Cusumano, A., Penalba, N., Del Valle, E., Juncos, L., Martinez Saye, J., Lef, L., Altobelli, V., Petraglia, G., Rosa Diez, G., Douthat, W., Lobo, J., Gallart, C., Lafalla, A., Diez, G., Linares, B., Lopez, N., Ramirez, N., Gonzalez, R., Valtuille, R., Beresan, H., Hermida, O., Rudolf, G., Marchetta, N., Rano, M., Ramirez, M., Garcia, N., Gillies, A., Jones, B., Pedagogos, E., Walker, R., Talaulikar, G., Bannister, K., Suranyi, M., Kark, A., Roger, S., Kerr, P., Disney, A., Mount, P., Fraenkel, M., Mathew, M., Fassett, R., Jose, M., Hawley, C., Lonergan, M., Mackie, J., Ferrari, P., Menahem, S., Sabto, J., Hutchison, B., Langham, R., Pollock, C., Holzer, H., Oberbauer, R., Arias, I., Graf, H., Mayer, G., Lhotta, K., Neyer, U., Klauser, R., Hoerl, W., Horn, S., Kovarik, J., Kramar, R., Eigner, M., Dhaene, M., Billiouw, J., De Meester, J., Warling, X., Cambier-Dwelschauwers, P., Evenepoel, P., Daelemans, R., Dratwa, M., Maes, B., Stolear, J., Dejagere, T., Vanwalleghem, J., Bouman, K., Jadoul, M., Peeters, J., Vanholder, R., Tielemans, C., Donck, J., Almeida, F., Picollo De Oliveira, J., Burdmann, E., Garcia, V., Saldanha Thome, F., Deboni, L., Bregman, R., Lugon, J., Araujo, S., Ferreira Filho, S., De Francesco Daher, E., Sperto Baptista, M., Carvalho, A., D'Avila, D., Moyses Neto, M., Yu, L., Bastos, M., Sampaio Lacativa, P., Jorgetti, V., De Almeida Romao, E., Cardeal Da Costa, J., Pecoits Filho, R., Gordan, P., Salgado, N., Teixeira Araujo, M., Neiva Coelho, S., Oliveira, I., Moyses, R., Vasconcellos, L., Batista, P., Luiz Gross, J., Pedrosa, A., Cournoyer, S., Leblanc, M., Chow, S., Karunakaran, S., Wong, G., Tobe, S., Desmeules, S., Zimmerman, D., Murphy, S., Montambault, P., Donnelly, S., Macrae, J., Culleton, B., Soroka, S., Rabbat, C., Jindal, K., Vasilevsky, M., Michaud, M., Wijeyesinghe, E., Zacharias, J., Lok, C., Muirhead, N., Verrelli, M., Da Roza, G., Sapir, D., Olgaard, K., Daugaard, H., Brandi, L., Jensen, P., Boulechfar, H., Ang, K., Simon, P., Rieu, P., Brunet, P., Touchard, G., Urena Torres, P., Combe, C., Durrbach, A., Ortiz, J., Hannedouche, T., Vela, C., Lionet, A., Ryckelynck, P., Zaoui, P., Choukroun, G., Fessi, H., Lang, P., Stroumza, P., Joly, D., Mousson, C., Laville, M., Dellanna, F., Erley, C., Braun, J., Rambausek, M., Riegel, W., Klingberg, M., Schwertfeger, E., Wizemann, V., Eckardt, K., Reichel, H., Passauer, J., Hubel, E., Frischmuth, N., Liebl, R., Fiedler, R., Schwenger, V., Vosskuhler, A., Kunzendorf, U., Renders, L., Rattensberger, D., Rump, L., Ketteler, M., Neumayer, H., Zantvoort, F., Stahl, R., Ladanyi, E., Kulcsar, I., Mezei, I., Csiky, B., Rikker, C., Arkossy, O., Berta, K., Szegedi, J., Major, L., Ferenczi, S., Fekete, A., Szabo, T., Zakar, G., Wagner, G., Kazup Erdelyine, S., Borbas, B., Eustace, J., Reddan, D., Capasso, G., Locatelli, F., Villa, G., Cozzolino, M., Brancaccio, D., Messa, P., Bolasco, P., Ricciardi, B., Malberti, F., Moriero, E., Cannella, G., Ortalda, V., Stefoni, S., Frasca, G., Cappelli, G., Albertazzi, A., Zoccali, C., Farina, M., Elli, A., Avella, F., Ondei, P., Mingardi, G., Errico, R., Losito, A., Di Giulio, S., Pertosa, G., Schena, F., Grandaliano, G., Gesualdo, L., Auricchio, M., Bochicchio-Ricardelli, T., Aranda Verastegui, F., Pena, J., Chew Wong, A., Cruz-Valdez, J., Torres Zamora, M., Solis, M., Sebastian Diaz, M., Vital Flores, M., Alvarez Sandoval, E., Van Den Dorpel, M., Brink, H., Van Kuijk, W., Vermeij, C., Smak Gregoor, P., Hagen, E., Van Der Sande, F., Klinger, M., Nowicki, M., Muszytowski, M., Bidas, K., Bentkowski, W., Wiecek, A., Ksiazek, A., Marczewski, K., Ostrowski, M., Switalski, M., Sulowicz, W., Matuszkiewicz-Rowinska, J., Mysliwiec, M., Durlik, M., Rutkowski, B., Macario, F., Carvalho, B., Frazao, J., Machado, D., Weigert, A., Andrusev, A., Khrustalev, O., Zemtchenkov, A., Gurevich, K., Staroselsky, K., Khadikova, N., Rozhinskaya, L., Timokhovskaya, G., Strokov, A., Balkarova, O., Ermolenko, V., Kolmakova, E., Komandenko, M., Timofeev, M., Shilo, V., Shostka, G., Smirnov, A., Anashkin, V., Volgina, G., Domashenko, O., Gurevich, A., Perlin, D., Martinez Garcia, J., Andres Ribes, E., Coll Piera, E., Fernandez Lucas, M., Galicia, M., Prados, M., Gonzalez, M., Romero, R., Martin de Francisco, A., Montenegro, J., Santiago, C., Garcia, F., Alcazar De La Ossa, J., Arrieta, J., Pons, J., Martin-Malo, A., Soler Amigo, J., Cases, A., Sterner, G., Jensen, G., Wikstrom, B., Jacobson, S., Lund, U., Weiss, L., Stahl, A., Von Albertini, B., Burnier, M., Meier, P., Martin, P., Uehlinger, D., Dickenmann, M., Yaqoob, M., Zehnder, D., Kalra, P., Padmanabhan, N., Roe, S., Eadington, D., Pritchard, N., Hutchison, A., Davies, S., Wilkie, M., Davies, M., Pai, P., Swift, P., Kwan, J., Goldsmith, D., Tomson, C., Stratton, J., Dasgupta, I., Sarkar, S., Moustafa, M., Gandhi, K., Jamal, A., Galindo-Ramos, E., Tuazon, J., Batlle, D., Tucker, K., Schiller-Moran, B., Assefi, A., Martinez, C., Samuels, L., Goldman, J., Cangiano-Rivera, J., Darwish, R., Lee, M., Topf, J., Kapatkin, K., Baer, H., Kopelman, R., Acharya, M., Tharpe, D., Bernardo, M., Nader, P., Guzman-Rivera, J., Pergola, P., Sekkarie, M., Alas, E., Zager, P., Liss, K., Navarro, J., Roppolo, M., Denu-Ciocca, C., Kshirsagar, A., El Khatib, M., Kant, K., Scott, D., Murthyr, B., Finkelstein, F., Keightley, G., Mccrary, R., Pitone, J., Cavalieri, T., Tsang, A., Pellegrino, B., Schmidt, R., Ahmad, S., Brown, C., Friedman, E., Mittman, N., Fadem, S., Shapiro, W., Reddy, M., Goldberger, S., Woredekal, Y., Agarwal, A., Anger, M., Haque, M., Chidester, P., Kohli, R., Rubinstein, S., Newman, G., Gladish, R., Ayodeji, O., Soman, S., Sprague, S., Hunt, N., Gehr, T., Rizk, D., Warnock, D., Polack, D., Pahl, M., Fischer, D., Dreyer, P., James, G., Husserl, F., Rogers, T., Raff, A., Sedor, J., Silver, M., Smith, M., Steinberg, S., Delgiorno, T., Jones, E., Cunha, P. D., Cheng, J., Pogue, V., Blumenthal, S., Brown, E., Charytan, C., Buerkert, J., Cook, M., Felsenfeld, A., Tareen, N., Gupta, A., Herman, T., Diamond, S., Hura, C., Laski, M., Maclaurin, J., Plumb, T., Brosnahan, G., Kumar, J., Henriquez, M., Poole, C., Osanloo, E., Matalon, A., Sholer, C., Arfeen, S., Azer, M., Belledonne, M., Gross, M., Dunnigan, E., Mcconnell, K., Becker, B., Skinner, F., Rigolosi, R., Spiegel, D., Stegman, M., Patak, R., Streja, D., Ranjit, U., Youell, T., Wooldridge, T., Stafford, C., Cottiero, R., Weinberg, M., Schonefeld, M., Shahmir, E., Hazzan, A., Ashfaq, A., Bhandari, K., Cleveland, W., Culpepper, M., Golden, J., Lai, L., Lien, Y., Lorica, V., Robertson, J., Malireddi, K., Morse, S., Thakur, V., Israelit, A., Raguram, P., Alfred, H., Weise, W., Al-Saghir, F., El Shahawy, M., Rastogi, A., Nissenson, A., Kopyt, N., Lynn, R., Lea, J., Mcclellan, W., Teredesai, P., Ong, S., Tolkan, S., Sugihara, J., Minga, T., Mehrotra, R., Minasian, R., Bhatia, D., Specter, R., Capelli, J., Sidhu, P., Dalal, S., Dykes, P., Khan, M., Rahim, F., Saklayen, M., Thomas, A., Michael, B., Torres, M., Al-Bander, H., Murray, B., Abukurah, A., Gupta, B., Nosrati, S., Raja, R., Zeig, S., Braun, M., Amatya, A., Endsley, J., Sharon, Z., Dolson, G., Dumler, F., Ntoso, K., Rosansky, S., Kumar, N., Gura, V., Thompson, N., Goldfarb, D., Halligan, R., Middleton, J., Widerhorn, A., Arbeit, L., Arruda, J., Crouch, T., Friedman, L., Khokhar, S., Mittleman, J., Light, P., Taparia, B., West, C., Cotton, J., Dhingra, R., Kleinman, L., Arif, F., Lew, S., Nammour, T., Sterrett, J., Williams, M., Ramirez, J., Rubin, J., Mccarthy, J., Noble, S., Chaffin, M., Rekhi, A., and Clinical sciences

Subjects
Adult, Male, Fibroblast growth factor 23, medicine.medical_specialty, Cinacalcet, Calcimimetic, medicine.medical_treatment, Naphthalenes, Hyperthyroidism, Gastroenterology, ventricular remodeling, Renal Dialysis, Cinacalcet Hydrochloride, Physiology (medical), Internal medicine, medicine, Humans, renal insufficiency, chronic, Aged, Etelcalcetide, calcium, business.industry, Research Support, Non-U.S. Gov't, death, sudden, cardiac, Middle Aged, arrhythmias, cardiac, Cardiovascular Diseases, Female, Fibroblast Growth Factors, Cardiology and Cardiovascular Medicine, medicine.disease, Fibroblast Growth Factor-23, Endocrinology, Randomized Controlled Trial, Secondary hyperparathyroidism, Hemodialysis, business, medicine.drug, Kidney disease
Abstract

Background— Patients with kidney disease have disordered bone and mineral metabolism, including elevated serum concentrations of fibroblast growth factor-23 (FGF23). These elevated concentrations are associated with cardiovascular and all-cause mortality. The objective was to determine the effects of the calcimimetic cinacalcet (versus placebo) on reducing serum FGF23 and whether changes in FGF23 are associated with death and cardiovascular events. Methods and Results— This was a secondary analysis of a randomized clinical trial comparing cinacalcet to placebo in addition to conventional therapy (phosphate binders/vitamin D) in patients receiving hemodialysis with secondary hyperparathyroidism (intact parathyroid hormone ≥300 pg/mL). The primary study end point was time to death or a first nonfatal cardiovascular event (myocardial infarction, hospitalization for angina, heart failure, or a peripheral vascular event). This analysis included 2985 patients (77% of randomized) with serum samples at baseline and 2602 patients (67%) with samples at both baseline and week 20. The results demonstrated that a significantly larger proportion of patients randomized to cinacalcet had ≥30% (68% versus 28%) reductions in FGF23. Among patients randomized to cinacalcet, a ≥30% reduction in FGF23 between baseline and week 20 was associated with a nominally significant reduction in the primary composite end point (relative hazard, 0.82; 95% confidence interval, 0.69–0.98), cardiovascular mortality (relative hazard, 0.66; 95% confidence interval, 0.50–0.87), sudden cardiac death (relative hazard, 0.57; 95% confidence interval, 0.37–0.86), and heart failure (relative hazard, 0.69; 95% confidence interval, 0.48–0.99). Conclusions— Treatment with cinacalcet significantly lowers serum FGF23. Treatment-induced reductions in serum FGF23 are associated with lower rates of cardiovascular death and major cardiovascular events. Clinical Trial Registration— URL: http://www.clinicaltrials.gov . Unique identifier: NCT00345839.

Published
2015

16. [Systemic scleroderma associated to a glomerulonephritis with anti-MPO antibodies: a case report and literature review]

Author

Eb, Sol, Florence Bonkain, Vande Houtte K, Dratwa M, and Inwendige Geneeskundige Specialiteiten

Subjects
Vasculitis, Scleroderma, Systemic, literature review, Platelet Count, Kidney Glomerulus, Case Report, Acute Kidney Injury, urologic and male genital diseases, Antibodies, Antineutrophil Cytoplasmic, Leukocyte Count, systemic scleroderma, Glomerulonephritis, Creatinine, Humans, Female, skin and connective tissue diseases, anti-MPO antibodies, Aged
Abstract

Besides the classic "renal crisis", a well known form of acute renal failure sometimes complicating scleroderma, another type of acute renal injury, even rarer and not well recognized, does exist: a crescentic glomerulonephritis associated with ANCA, and more seldom with anti-GBM antibodies, which is often (but not always) secondary to the use of D-penicillamine. We report the case of a 70 years-old female who presented with a severe acute renal failure accompanied by positive anti-MPO ANCA as well as anti-GBM antibodies. She had a long history of systemic scleroderma which had been treated with D-penicillamine for many years. The clinical picture was typical of an ANCA-positive vasculitis of the microscopic form of polyangeitis, with a crescentic glomerulonephritis on renal biopsy. Unfortunately, the patient died despite therapy with plasma exchanges and immunosuppressive drugs. Some forty cases of crescentic glomerulonephritis associated with scleroderma have been reported. They were initially considered as always associated with D-penicillamine use, but more recently some observations have been made outside this drug context. As will be shown through a literature review, it can be concluded that there are two (or even three according to some authors) forms of acute renal involvement associated to scleroderma, which should be distinguished as soon as possible, given the quite differing therapeutic and prognostic consequences of this distinction.

Published
2009

17. European best practice guidelines for peritoneal dialysis. 2 The initiation of dialysis

Author

Dombros, N., Dratwa, M., Gokal, R., Heimbürger, O., Krediet, R., Plum, J., Rodrigues, A., Selgas, R., Struijk, D., and Verger, C.

Abstract

Submitted by José Pereira (jro.pereira@gmail.com) on 2011-08-23T09:29:07Z No. of bitstreams: 1 2 The initiation of dialysis.pdf: 87844 bytes, checksum: 5c080c9ab1173f9ebfee5eec8ec18fd9 (MD5) Made available in DSpace on 2011-08-23T09:29:07Z (GMT). No. of bitstreams: 1 2 The initiation of dialysis.pdf: 87844 bytes, checksum: 5c080c9ab1173f9ebfee5eec8ec18fd9 (MD5) Previous issue date: 2005-12

Published
2005

18. European best practice guidelines for peritoneal dialysis. 9 PD and transplantation

Author

Dombros, N., Dratwa, M., Feriani, M., Gokal, R., Heimbürger, O., Krediet, R., Plum, J., Rodrigues, A., Selgas, R., Struijk, D., and Christian VERGER

Abstract

Submitted by José Pereira (jro.pereira@gmail.com) on 2011-08-22T17:57:55Z No. of bitstreams: 1 9 PD and transplantation.pdf: 53575 bytes, checksum: 8907991c4f4b6fbd1de16c92bef2881f (MD5) Made available in DSpace on 2011-08-22T17:57:56Z (GMT). No. of bitstreams: 1 9 PD and transplantation.pdf: 53575 bytes, checksum: 8907991c4f4b6fbd1de16c92bef2881f (MD5) Previous issue date: 2005-12

Published
2005

19. European best practice guidelines for peritoneal dialysis. 1 General guidelines

Author

Dombros, N., Dratwa, M., Feriani, M., Gokal, R., Heimbürger, O., Krediet, R., Plum, J., Rodrigues, A., Selgas, R., Struijk, D., and Christian VERGER

Abstract

Submitted by José Pereira (jro.pereira@gmail.com) on 2011-08-23T09:57:48Z No. of bitstreams: 1 1 General guidelines.pdf: 27217 bytes, checksum: 1cd0dfbdbacd077f8927f57145d9f738 (MD5) Made available in DSpace on 2011-08-23T09:57:48Z (GMT). No. of bitstreams: 1 1 General guidelines.pdf: 27217 bytes, checksum: 1cd0dfbdbacd077f8927f57145d9f738 (MD5) Previous issue date: 2005-12

Published
2005

20. European best practice guidelines for peritoneal dialysis. 4 Continuous ambulatory peritoneal dialysis delivery systems

Author

Dombros, N., Dratwa, M., Feriani, M., Gokal, R., Heimbürger, O., Krediet, R., Plum, J., Rodrigues, A., Selgas, R., Struijk, D., and Christian VERGER

Abstract

Submitted by José Pereira (jro.pereira@gmail.com) on 2011-08-23T10:20:06Z No. of bitstreams: 1 4 Continuous ambulatory peritoneal dialysis delivery systems.pdf: 60302 bytes, checksum: d78e67f7480a84e926b814b23d7f3115 (MD5) Made available in DSpace on 2011-08-23T10:20:06Z (GMT). No. of bitstreams: 1 4 Continuous ambulatory peritoneal dialysis delivery systems.pdf: 60302 bytes, checksum: d78e67f7480a84e926b814b23d7f3115 (MD5) Previous issue date: 2005-12

Published
2005

21. European best practice guidelines for peritoneal dialysis. 3 Peritoneal access

Author

Dombros, N., Dratwa, M., Gokal, R., Heimbürger, O., Krediet, R., Plum, J., Rodrigues, A., Selgas, R., Struijk, D., and Verger, C.

Abstract

Submitted by José Pereira (jro.pereira@gmail.com) on 2011-08-22T17:47:17Z No. of bitstreams: 1 3 Peritoneal access.pdf: 82764 bytes, checksum: 06471e283762bd4684c6e6d805a748b6 (MD5) Made available in DSpace on 2011-08-22T17:47:17Z (GMT). No. of bitstreams: 1 3 Peritoneal access.pdf: 82764 bytes, checksum: 06471e283762bd4684c6e6d805a748b6 (MD5) Previous issue date: 2005-12

Published
2005

22. European best practice guidelines for peritoneal dialysis. 5 Peritoneal dialysis solutions

Author

Dombros, N., Dratwa, M., Feriani, M., Gokal, R., Heimbürger, O., Krediet, R., Plum, J., Rodrigues, A., Selgas, R., Struijk, D., and Christian VERGER

Abstract

Submitted by José Pereira (jro.pereira@gmail.com) on 2011-08-23T10:13:22Z No. of bitstreams: 1 5 Peritoneal dialysis solutions.pdf: 85101 bytes, checksum: 3dc591a5e0feb1c9f0cc1683aacb2421 (MD5) Made available in DSpace on 2011-08-23T10:13:22Z (GMT). No. of bitstreams: 1 5 Peritoneal dialysis solutions.pdf: 85101 bytes, checksum: 3dc591a5e0feb1c9f0cc1683aacb2421 (MD5) Previous issue date: 2005-12

Published
2005

25. Peritoneal dialysis - A

Author

Ito, M., primary, Emami-Naini, A., additional, Keyvandarian, N., additional, Moeinzadeh, F., additional, Mortazavi, M., additional, Taheri, S., additional, Io, K., additional, Nishino, T., additional, Obata, Y., additional, Kitamura, M., additional, Abe, S., additional, Koji, T., additional, Kohno, S., additional, Wakabayashi, K., additional, Hamada, C., additional, Nakano, T., additional, Kanda, R., additional, Io, H., additional, Horikoshi, S., additional, Tomino, Y., additional, Korte, M. R., additional, Braun, N., additional, Habib, S. M., additional, Goffin, E., additional, Summers, A., additional, Heuveling, L., additional, Betjes, M. G. H., additional, Lambie, M., additional, Bankart, J., additional, Johnson, D., additional, Mactier, R., additional, Phillips-Darby, L., additional, Topley, N., additional, Davies, S., additional, Liu, F. X., additional, Leipold, R., additional, Arici, M., additional, Farooqui, U., additional, Cho, K.-h., additional, Do, J.-y., additional, Kang, S.-h., additional, Park, J.-W., additional, Yoon, K.-W., additional, Jung, S.-Y., additional, Sise, C., additional, Rutherford, P., additional, Kovacs, L., additional, Konings, S., additional, Pestana, M., additional, Zimmermann, J., additional, Cramp, H., additional, Stein, D., additional, Bang, K., additional, Shin, J. H., additional, Jeong, J., additional, Kim, J.-H., additional, Matsuo, N., additional, Maruyama, Y., additional, Nakao, M., additional, Tanno, Y., additional, Ohkido, I., additional, Hayakawa, H., additional, Yamamoto, H., additional, Yokoyama, K., additional, Hosoya, T., additional, Iannuzzella, F., additional, Corradini, M., additional, Belloni, L., additional, Stefani, A., additional, Parmeggiani, M., additional, Pasquali, S., additional, Svedberg, O., additional, Stenvinkel, P., additional, Qureshi, A. R., additional, Barany, P., additional, Heimburger, O., additional, Leurs, P., additional, Anderstam, B., additional, Waniewski, J., additional, Antosiewicz, S., additional, Baczynski, D., additional, Galach, M., additional, Wankowicz, Z., additional, Prabhu, M., additional, Subhramanyam, S. V., additional, Nayak, K. S., additional, Hwang, J.-C., additional, Jiang, M.-Y., additional, Lu, Y.-H., additional, Wang, C.-T., additional, Santos, C., additional, Rodriguez-Carmona, A., additional, Perez Fontan, M., additional, Schaefer, B., additional, Macher-Goeppinger, S., additional, Bayazit, A., additional, Sallay, P., additional, Testa, S., additional, Holland-Cunz, S., additional, Querfeld, U., additional, Warady, B. A., additional, Schaefer, F., additional, Schmitt, C. P., additional, Guney, I., additional, Turkmen, K., additional, Yazici, R., additional, Aslan, S., additional, Altintepe, L., additional, Yeksan, M., additional, Kocyigit, I., additional, Sipahioglu, M., additional, Orscelik, O., additional, Unal, A., additional, Celik, A., additional, Abbas, S., additional, Zhu, F., additional, Tokgoz, B., additional, Dogan, A., additional, Oymak, O., additional, Kotanko, P., additional, Levin, N., additional, Sanchez-Gonzalez, M. C., additional, Gonzalez-Casaus, M. L., additional, Gonzalez-Parra, E., additional, Albalate, M., additional, Lorenzo, V., additional, Torregrosa, V., additional, Fernandez, E., additional, de la Piedra, C., additional, Rodriguez, M., additional, Zeiler, M., additional, Monteburini, T., additional, Agostinelli, R. M., additional, Marinelli, R., additional, Santarelli, S., additional, Bermond, F., additional, Bagnis, C., additional, Marcuccio, C., additional, Soragna, G., additional, Bruno, M., additional, Vitale, C., additional, Marangella, M., additional, Martino, F., additional, Scalzotto, E., additional, Rodighiero, M. P., additional, Crepaldi, C., additional, Ronco, C., additional, Seferi, S., additional, Rroji, M., additional, Likaj, E., additional, Barbullushi, M., additional, Thereska, N., additional, Kim, E. J., additional, Han, J. H., additional, Koo, H. M., additional, Doh, F. M., additional, Kim, C. H., additional, Ko, K. I., additional, Lee, M. J., additional, Oh, H. J., additional, Han, S. H., additional, Yoo, T.-H., additional, Choi, K. H., additional, Kang, S.-W., additional, Uzun, S., additional, Karadag, S., additional, Yegen, M., additional, Gursu, M., additional, Ozturk, S., additional, Aydin, Z., additional, Sumnu, A., additional, Cebeci, E., additional, Atalay, E., additional, Kazancioglu, R., additional, Alscher, D., additional, Fritz, P., additional, Latus, J., additional, Kimmel, M., additional, Biegger, D., additional, Lindenmeyer, M., additional, Cohen, C. D., additional, Wuthrich, R. P., additional, Segerer, S., additional, Kim, Y. K., additional, Kim, H. W., additional, Song, H. C., additional, Choi, E. J., additional, Yang, C. W., additional, Matsuda, A., additional, Tayama, Y., additional, Ogawa, T., additional, Iwanaga, M., additional, Okazaki, S., additional, Hatano, M., additional, Kiba, T., additional, Shimizu, T., additional, Hasegawa, H., additional, Mitarai, T., additional, Dratwa, M., additional, Collart, F., additional, Verger, C., additional, Takayanagi, K., additional, Iwashita, T., additional, Noiri, C., additional, Inamura, M., additional, Nakamura, S., additional, Kato, H., additional, Sipahioglu, M. H., additional, Elmali, F., additional, Zhang, X., additional, Ma, J., additional, Giuliani, A., additional, Blanca-Martos, L., additional, Nayak Karopadi, A., additional, Mason, G., additional, Santos, M. T., additional, Fonseca, I., additional, Santos, O., additional, Rocha, M. J., additional, Carvalho, M. J., additional, Cabrita, A., additional, Rodrigues, A., additional, Scabbia, L., additional, Domenici, A., additional, Apponi, F., additional, Tayefeh Jafari, M., additional, Sivo, F., additional, Falcone, C., additional, Punzo, G., additional, Mene, P., additional, Yildirim, T., additional, Yilmaz, R., additional, Azak, A., additional, Altindal, M., additional, Turkmen, E., additional, Altun, B., additional, Duranay, M., additional, Erdem, Y., additional, Buyukbakkal, M., additional, Eser, B., additional, Yayar, O., additional, Ercan, Z., additional, Kali, A., additional, Erdogan, B., additional, Haspulat, A., additional, Merhametsiz, O., additional, Ulusal-Okyay, G., additional, Akdag, S. I., additional, Ayli, M. D., additional, Pietrzycka, A., additional, Miarka, P., additional, Chowaniec, E., additional, Sulowicz, W., additional, Lutwin, M., additional, Gaska, M., additional, and Paciorek, A., additional

Published
2013
Full Text
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28. Epidemiology and outcome research in CKD 5D

Author

Coentrao, L., primary, Ribeiro, C., additional, Santos-Araujo, C., additional, Neto, R., additional, Pestana, M., additional, Kleophas, W., additional, Karaboyas, A., additional, LI, Y., additional, Bommer, J., additional, Pisoni, R., additional, Robinson, B., additional, Port, F., additional, Celik, G., additional, Burcak Annagur, B., additional, Yilmaz, M., additional, Demir, T., additional, Kara, F., additional, Trigka, K., additional, Dousdampanis, P., additional, Vaitsis, N., additional, Aggelakou-Vaitsi, S., additional, Turkmen, K., additional, Guney, I., additional, Turgut, F., additional, Altintepe, L., additional, Tonbul, H. Z., additional, Abdel-Rahman, E., additional, Sclauzero, P., additional, Galli, G., additional, Barbati, G., additional, Carraro, M., additional, Panzetta, G. O., additional, Van Diepen, M., additional, Schroijen, M., additional, Dekkers, O., additional, Dekker, F., additional, Sikole, A., additional, Severova- Andreevska, G., additional, Trajceska, L., additional, Gelev, S., additional, Amitov, V., additional, Pavleska- Kuzmanovska, S., additional, Rayner, H., additional, Vanholder, R., additional, Hecking, M., additional, Jung, B., additional, Leung, M., additional, Huynh, F., additional, Chung, T., additional, Marchuk, S., additional, Kiaii, M., additional, Er, L., additional, Werb, R., additional, Chan-Yan, C., additional, Beaulieu, M., additional, Malindretos, P., additional, Makri, P., additional, Zagkotsis, G., additional, Koutroumbas, G., additional, Loukas, G., additional, Nikolaou, E., additional, Pavlou, M., additional, Gourgoulianni, E., additional, Paparizou, M., additional, Markou, M., additional, Syrgani, E., additional, Syrganis, C., additional, Raimann, J., additional, Usvyat, L. A., additional, Bhalani, V., additional, Levin, N. W., additional, Kotanko, P., additional, Huang, X., additional, Stenvinkel, P., additional, Qureshi, A. R., additional, Riserus, U., additional, Cederholm, T., additional, Barany, P., additional, Heimburger, O., additional, Lindholm, B., additional, Carrero, J. J., additional, Chang, J. H., additional, Sung, J. Y., additional, Jung, J. Y., additional, Lee, H. H., additional, Chung, W., additional, Kim, S., additional, Han, J. S., additional, Na, K. Y., additional, Fragoso, A., additional, Pinho, A., additional, Malho, A., additional, Silva, A. P., additional, Morgado, E., additional, Leao Neves, P., additional, Joki, N., additional, Tanaka, Y., additional, Iwasaki, M., additional, Kubo, S., additional, Hayashi, T., additional, Takahashi, Y., additional, Hirahata, K., additional, Imamura, Y., additional, Hase, H., additional, Castledine, C., additional, Gilg, J., additional, Rogers, C., additional, Ben-Shlomo, Y., additional, Caskey, F., additional, Sandhu, J. S., additional, Bajwa, G. S., additional, Kansal, S., additional, Sandhu, J., additional, Jayanti, A., additional, Nikam, M., additional, Ebah, L., additional, Summers, A., additional, Mitra, S., additional, Agar, J., additional, Perkins, A., additional, Simmonds, R., additional, Tjipto, A., additional, Amet, S., additional, Launay-Vacher, V., additional, Laville, M., additional, Tricotel, A., additional, Frances, C., additional, Stengel, B., additional, Gauvrit, J.-Y., additional, Grenier, N., additional, Reinhardt, G., additional, Clement, O., additional, Janus, N., additional, Rouillon, L., additional, Choukroun, G., additional, Deray, G., additional, Bernasconi, A., additional, Waisman, R., additional, Montoya, A. P., additional, Liste, A. A., additional, Hermes, R., additional, Muguerza, G., additional, Heguilen, R., additional, Iliescu, E. L., additional, Martina, V., additional, Rizzo, M. A., additional, Magenta, P., additional, Lubatti, L., additional, Rombola, G., additional, Gallieni, M., additional, Loirat, C., additional, Mellerio, H., additional, Labeguerie, M., additional, Andriss, B., additional, Savoye, E., additional, Lassale, M., additional, Jacquelinet, C., additional, Alberti, C., additional, Aggarwal, Y., additional, Baharani, J., additional, Tabrizian, S., additional, Ossareh, S., additional, Zebarjadi, M., additional, Azevedo, P., additional, Travassos, F., additional, Frade, I., additional, Almeida, M., additional, Queiros, J., additional, Silva, F., additional, Cabrita, A., additional, Rodrigues, R., additional, Couchoud, C., additional, Kitty, J., additional, Benedicte, S., additional, Fergus, C., additional, Cecile, C., additional, Sahar, B., additional, Emmanuel, V., additional, Christian, J., additional, Rene, E., additional, Barahimi, H., additional, Mahdavi-Mazdeh, M., additional, Nafar, M., additional, Petruzzi, M., additional, De Benedittis, M., additional, Sciancalepore, M., additional, Gargano, L., additional, Natale, P., additional, Vecchio, M. C., additional, Saglimbene, V., additional, Pellegrini, F., additional, Gentile, G., additional, Stroumza, P., additional, Frantzen, L., additional, Leal, M., additional, Torok, M., additional, Bednarek, A., additional, Dulawa, J., additional, Celia, E., additional, Gelfman, R., additional, Hegbrant, J., additional, Wollheim, C., additional, Palmer, S., additional, Johnson, D. W., additional, Ford, P. J., additional, Craig, J. C., additional, Strippoli, G. F., additional, Ruospo, M., additional, El Hayek, B., additional, Hayek, B., additional, Baamonde, E., additional, Bosch, E., additional, Ramirez, J. I., additional, Perez, G., additional, Ramirez, A., additional, Toledo, A., additional, Lago, M. M., additional, Garcia-Canton, C., additional, Checa, M. D., additional, Canaud, B., additional, Lantz, B., additional, Granger-Vallee, A., additional, Lertdumrongluk, P., additional, Molinari, N., additional, Ethier, J., additional, Jadoul, M., additional, Gillespie, B., additional, Bond, C., additional, Wang, S., additional, Alfieri, T., additional, Braunhofer, P., additional, Newsome, B., additional, Wang, M., additional, Bieber, B., additional, Guidinger, M., additional, Zuo, L., additional, Yu, X., additional, Yang, X., additional, Qian, J., additional, Chen, N., additional, Albert, J., additional, Yan, Y., additional, Ramirez, S., additional, Beresan, M., additional, Lapidus, A., additional, Canteli, M., additional, Tong, A., additional, Manns, B., additional, Craig, J., additional, Strippoli, G., additional, Mortazavi, M., additional, Vahdatpour, B., additional, Shahidi, S., additional, Ghasempour, A., additional, Taheri, D., additional, Dolatkhah, S., additional, Emami Naieni, A., additional, Ghassami, M., additional, Khan, M., additional, Abdulnabi, K., additional, Pai, P., additional, Vecchio, M., additional, Muqueet, M. A., additional, Hasan, M. J., additional, Kashem, M. A., additional, Dutta, P. K., additional, Liu, F. X., additional, Noe, L., additional, Quock, T., additional, Neil, N., additional, Inglese, G., additional, Motamed Najjar, M., additional, Bahmani, B., additional, Shafiabadi, A., additional, Helve, J., additional, Haapio, M., additional, Groop, P.-H., additional, Gronhagen-Riska, C., additional, Finne, P., additional, Sund, R., additional, Cai, M., additional, Baweja, S., additional, Clements, A., additional, Kent, A., additional, Reilly, R., additional, Taylor, N., additional, Holt, S., additional, Mcmahon, L., additional, Carter, M., additional, Van der Sande, F. M., additional, Kooman, J., additional, Malhotra, R., additional, Ouellet, G., additional, Penne, E. L., additional, Thijssen, S., additional, Etter, M., additional, Tashman, A., additional, Guinsburg, A., additional, Grassmann, A., additional, Barth, C., additional, Marelli, C., additional, Marcelli, D., additional, Von Gersdorff, G., additional, Bayh, I., additional, Scatizzi, L., additional, Lam, M., additional, Schaller, M., additional, Toffelmire, T., additional, Wang, Y., additional, Sheppard, P., additional, Neri, L., additional, Andreucci, V. A., additional, Rocca-Rey, L. A., additional, Bertoli, S. V., additional, Brancaccio, D., additional, De Berardis, G., additional, Lucisano, G., additional, Johnson, D., additional, Nicolucci, A., additional, Bonifati, C., additional, Navaneethan, S. D., additional, Montinaro, V., additional, Zsom, M., additional, Bednarek-Skublewska, A., additional, Graziano, G., additional, Ferrari, J. N., additional, Santoro, A., additional, Zucchelli, A., additional, Triolo, G., additional, Maffei, S., additional, De Cosmo, S., additional, Manfreda, V. M., additional, Juillard, L., additional, Rousset, A., additional, Butel, F., additional, Girardot-Seguin, S., additional, Hannedouche, T., additional, Isnard, M., additional, Berland, Y., additional, Vanhille, P., additional, Ortiz, J.-P., additional, Janin, G., additional, Nicoud, P., additional, Touam, M., additional, Bruce, E., additional, Grace, B., additional, Clayton, P., additional, Cass, A., additional, Mcdonald, S., additional, Furumatsu, Y., additional, Kitamura, T., additional, Fujii, N., additional, Ogata, S., additional, Nakamoto, H., additional, Iseki, K., additional, Tsubakihara, Y., additional, Chien, C.-C., additional, Wang, J.-J., additional, Hwang, J.-C., additional, Wang, H.-Y., additional, Kan, W.-C., additional, Kuster, N., additional, Patrier, L., additional, Bargnoux, A.-S., additional, Morena, M., additional, Dupuy, A.-M., additional, Badiou, S., additional, Cristol, J.-P., additional, Desmet, J.-M., additional, Fernandes, V., additional, Collart, F., additional, Spinogatti, N., additional, Pochet, J.-M., additional, Dratwa, M., additional, Goffin, E., additional, Nortier, J., additional, Zilisteanu, D. S., additional, Voiculescu, M., additional, Rusu, E., additional, Achim, C., additional, Bobeica, R., additional, Balanica, S., additional, Atasie, T., additional, Florence, S., additional, Anne-Marie, S., additional, Michel, L., additional, Cyrille, C., additional, Strakosha, A., additional, Pasko, N., additional, Kodra, S., additional, Thereska, N., additional, Lowney, A., additional, Lowney, E., additional, Grant, R., additional, Murphy, M., additional, Casserly, L., additional, O' Brien, T., additional, Plant, W. D., additional, Radic, J., additional, Ljutic, D., additional, Kovacic, V., additional, Radic, M., additional, Dodig-Curkovic, K., additional, Sain, M., additional, Jelicic, I., additional, Hamano, T., additional, Nakano, C., additional, Yonemoto, S., additional, Okuno, A., additional, Katayama, M., additional, Isaka, Y., additional, Nordio, M., additional, Limido, A., additional, Postorino, M., additional, Nichelatti, M., additional, Khil, M., additional, Dudar, I., additional, Khil, V., additional, Shifris, I., additional, Momtaz, M., additional, Soliman, A. R., additional, El Lawindi, M. I., additional, Dzekova-Vidimliski, P., additional, Pavleska-Kuzmanovska, S., additional, Nikolov, I., additional, Selim, G., additional, Shoji, T., additional, Kakiya, R., additional, Tatsumi-Shimomura, N., additional, Tsujimoto, Y., additional, Tabata, T., additional, Shima, H., additional, Mori, K., additional, Fukumoto, S., additional, Tahara, H., additional, Koyama, H., additional, Emoto, M., additional, Ishimura, E., additional, Nishizawa, Y., additional, and Inaba, M., additional

Published
2012
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37. Lipid and apoprotein changes during atorvastatin up-titration in hemodialysis patients with hypercholesterolemia: a placebo-controlled study

Author

Lins, R.L., primary, Matthys, K.E., additional, Billiouw, J.M., additional, Dratwa, M., additional, Dupont, P., additional, Lameire, N.H., additional, Peeters, P.C., additional, Stolear, J.-C., additional, Tielemans, C., additional, Maes, B., additional, Ducobu, G.A. Verpooten J., additional, and Carpentier, Y.A., additional

Published
2004
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40. P207 Calciphylaxis

Author

GHEERAERT, P, primary, THEUNIS, A, additional, ANDRE, J, additional, DRATWA, M, additional, and SONG, M, additional

Published
1997
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50. Critical Role of Iron Overload in the Increased Susceptibility of Haemodialysis Patients to Bacterial Infections. Beneficial Effects of Desferrioxamine.

Author

Tielemans, C. L., Lenclud, C. M., Wens, R., Collart, F. E., and Dratwa, M.

Abstract

Iron overload, which is a common complication in haemodialysis patients, is known to enhance bacterial growth and virulence, and to alter phagocytosis. We reviewed the data of 61 haemodialysed patients to clarify the clinical relevance of iron status to the risk of bacterial infection. Increased concentrations of serum ferritin were associated with a greater infection rate (<0.0025), which was already true for ferritin values between 500 and l000μ/l (.<0.025). Furthermore, in 21 iron-overloaded patients treated with an iron-chelator (desferrioxamine), the infection rate decreased from 1/19 patient-months to 1/112 (<0.005), and returned to previous values when desferrioxamine was stopped. Our results demonstrate the importance of haemosiderosis in the increased susceptibility of haemodialysed patients to infections; this susceptibility is decreased by desferrioxamine therapy, which probably acts by restoring phagocytosis and reducing the bioavailability of iron for pathogens. [ABSTRACT FROM PUBLISHER]

Published
1989

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