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511 results on '"Drash, A L"'

5. Cholesterol screening of children

Author

Kashani, Iraj A., Nader, Philip R., Stuhldreher, Wendy L., Orchard, Trevor J., Donahue, Richard P., Drash, Allan L., Shannon, Barbara, Tershakovec, Andrew M., Cortner, Jean A., Lauer, Ronald M., Clarke, William B., Newman, Thomas B., Browner, Warren S., Hulley, Stephen B., Domenighetti, Gianfranco, Casabianca, Antoine, Barazzoni, Fabrizio, and Lopipero, Peggy

Subjects
Medical screening -- Analysis, Hypercholesterolemia in children -- Diagnosis, Blood cholesterol -- Measurement
Published
1991

13. Prevalence of complications in IDDM by sex and duration: Pittsburgh Epidemiology of Diabetes Complications Study II

Author

Orchard, Trevor J., Dorman, Janice S., Maser, Raelene E., Becker, Dorothy J., Drash, Allan L., Ellis, Demetrius, LaPorte, Ronald E., and Kuller, Lewis H.

Subjects
Hyperglycemia -- Physiological aspects, Type 1 diabetes -- Demographic aspects, Type 1 diabetes -- Complications, Health
Abstract

Insulin-dependent diabetes mellitus (IDDM) is a disease in which destruction of the insulin-secreting pancreatic beta cells results in the inability to regulate blood glucose levels. The resulting high blood glucose (hyperglycemia) is deleterious to a several organs, and must be controlled with injections of insulin. The inability to completely compensate for the pancreatic deficiency inevitably leads to complications in long-term diabetes. These complications include retinopathy (disorders of the retina of the eye), nephropathy (kidney disease), microalbuminurea (the presence of protein in the urine, often a sign of kidney malfunction), cardiovascular disease, and neuropathy (impaired function of the nerves). It is thought that these disorders may not be equally represented in males and females, and that this asymmetry may vary with the duration of the diabetic state. To further investigate this issue, the records of 657 patients diagnosed with IDDM between 1950 and 1980 were studied. The patients ranged in age from 8 to 48 years, and males and females were equally represented. All disorders showed an increase in incidence with increasing disease duration. The most prevalent finding was mild retinopathy, which was present in almost 100 percent of the patients who had been diabetic for over 20 years; no sex difference observed. Severe retinopathy was found in 70 percent of the subjects after 30 years of IDDM. However, it was more prevalent in females with short-duration IDDM and males with longer-duration (greater than 25 years) IDDM. Kidney dysfunction was more common among females with short disease duration; by 30 years the prevalence was about 45 percent in both sexes. Males experienced more severe microalbuminurea; after 30 years of IDDM, the prevalence of both microalbuminurea and nephropathy was 84 percent in males, but only 59 percent in females. Neuropathy and cardiovascular disease showed very minor sex differences, and attained a prevalence of 70 percent and 10 percent, respectively, after 30 years of IDDM. These findings demonstrate that the natural course of IDDM affects the sexes differently, and that the prevalence of these complications is somewhat higher than has been previously reported. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

24. The Independent Influence of Specialist Care on Diabetes Complications: A Longitudinal Analysis

Author

ZGIBOR, JANICE C., SONGER, THOMAS J., and DRASH, ALLAN L.

Subjects
Type 1 diabetes -- Care and treatment, Medical care -- Utilization, Diabetic retinopathy -- Care and treatment, Diabetic nephropathies -- Care and treatment, Diabetic neuropathies -- Care and treatment, Health
Abstract

Specialist care (SC) has been shown to result in better short term diabetes outcomes, such as glycemic control, however, the influence of SC on the development of long-term complications in [...]

Published
2000

30. Epidemiological correlates of diabetic neuropathy: report from Pittsburgh epidemiology of diabetes complications study

Author

Maser, Raelene E., Steenkiste, Ann R., Dorman, Janice S., Nielsen, Viggo Kamp, Bass, Eric B., Manjoo, Qurashia, Drash, Allan L., Becker, Dorothy J., Kuller, Lewis H., Greene, Douglas A., and Orchard, Trevor J.

Subjects
Diabetes -- Complications and side effects -- Risk factors -- Models, Diabetic neuropathies -- Risk factors -- Models -- Complications and side effects, Health, Complications and side effects, Models, Risk factors
Abstract

The pathogenesis of diabetic neuropathy is not fully understood, and its risk factors remain obscure. Although the sequelae of the development of diabetic neuropathy can be studied in animal models, [...]

Published
1989

42. Employment spectrum of IDDM.

Author

Songer, Thomas J., LaPorte, Ronald E., Dorman, Janice S., Orchard, Trevor J., Becker, Dorothy J., Drash, Allan L., Songer, T J, LaPorte, R E, Dorman, J S, Orchard, T J, Becker, D J, and Drash, A L

Published
1989
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44. Motor vehicle accidents and IDDM.

Author

Songer, Thomas J., Laporte, Ronald E., Dorman, Janice S., Orchard, Trevor J., Cruickshanks, Karen J., Becker, Dorothy J., Drash, Allan L., Songer, T J, LaPorte, R E, Dorman, J S, Orchard, T J, Cruickshanks, K J, Becker, D J, and Drash, A L

Published
1988
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