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2. Cost-Effectiveness of a Shock Team Approach in Refractory Cardiogenic Shock

Author

Taleb, Iosif, Giannouchos, Theodoros V., Kyriakopoulos, Christos P., Clawson, Antoine, Davis, Erin S., Sideris, Konstantinos, Tseliou, Eleni, Shah, Kevin S., Tonna, Joseph E., Dranow, Elizabeth, Jones, Tara L., Carter, Spencer J., Fang, James C., Stehlik, Josef, Ohsfeldt, Robert L., Selzman, Craig H., Hanff, Thomas C., and Drakos, Stavros G.

Published
2024
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3. Clinical-transcriptional prioritization of the circulating proteome in human heart failure

Author

Perry, Andrew S., Amancherla, Kaushik, Huang, Xiaoning, Lance, Michelle L., Farber-Eger, Eric, Gajjar, Priya, Amrute, Junedh, Stolze, Lindsey, Zhao, Shilin, Sheng, Quanhu, Joynes, Cassandra M., Peng, Zhongsheng, Tanaka, Toshiko, Drakos, Stavros G., Lavine, Kory J., Selzman, Craig, Visker, Joseph R., Shankar, Thirupura S., Ferrucci, Luigi, Das, Saumya, Wilcox, Jane, Patel, Ravi B., Kalhan, Ravi, Shah, Sanjiv J., Walker, Keenan A., Wells, Quinn, Tucker, Nathan, Nayor, Matthew, Shah, Ravi V., and Khan, Sadiya S.

Published
2024
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4. Cardiac Reverse Remodeling Mediated by HeartMate 3 Left Ventricular Assist Device: Comparison to Older Generation Devices

Author

Yin, Michael Yaoyao, Maneta, Eleni, Kyriakopoulos, Christos P., Michaels, Alexander T., Genovese, Leonard D., Indaram, Mahathi B., Wever-Pinzon, Omar, Singh, Ramesh, Tseliou, Eleni, Taleb, Iosif, Nemeh, Hassan W., Alharethi, Rami, Tang, Daniel G., Goldstein, Jake, Hanff, Thomas C., Selzman, Craig H., Cowger, Jennifer, Kanwar, Manreet, Shah, Palak, and Drakos, Stavros G.

Published
2024
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7. SMYD1a protects the heart from ischemic injury by regulating OPA1-mediated cristae remodeling and supercomplex formation

Author

Szulik, Marta W., Valdez, Steven, Walsh, Maureen, Davis, Kathryn, Bia, Ryan, Horiuchi, Emilee, O’Very, Sean, Laxman, Anil K., Sandaklie-Nicolova, Linda, Eberhardt, David R., Durrant, Jessica R., Sheikh, Hanin, Hickenlooper, Samuel, Creed, Magnus, Brady, Cameron, Miller, Mickey, Wang, Li, Garcia-Llana, June, Tracy, Christopher, Drakos, Stavros G., Funai, Katsuhiko, Chaudhuri, Dipayan, Boudina, Sihem, and Franklin, Sarah

Published
2023
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10. Heart failure related cardiogenic shock: An ISHLT consensus conference content summary

Author

Overgaard, Chris, Teuteberg, Jeffrey, Rosner, Carolyn, Nagpal, Dave, Taimeh, Ziad, Abraham, Jacob, Ton, Van-Khue, Drakos, Stavros, Tehrani, Behnam, Bernhardt, Alexander, Meeran, Talha, Douglas Greig, P., Farrero, Marta, Katz, Jason, Luk, Adriana, Bennett, Courtney, Bertolotti, Alejandro, Tedford, Ryan J., Cogswell, Rebecca, Klein, Liviu, Guerrero-Miranda, Cesar Y., Rampersad, Penelope, Potena, Luciano, Boeken, Udo, Copeland, Hannah, Hall, Shelley, González-Costello, José, Kapur, Navin K., Loforte, Antonio, Burkhoff, Daniel, LePrince, Pascal, Gustafsson, Finn, Uriel, Nir, Kataria, Rachna, Arora, Sonali, Masetti, Marco, Saeed, Diyar, Kanwar, Manreet K., Billia, Filio, Randhawa, Varinder, Cowger, Jennifer A., Barnett, Christopher M., Chih, Sharon, Ensminger, Stephan, Hernandez-Montfort, Jaime, Sinha, Shashank S., Vorovich, Esther, Proudfoot, Alastair, Lim, Hoong S., Blumer, Vanessa, Jennings, Douglas L., Garan, A. Reshad, Renedo, Maria F., Hanff, Thomas C., and Baran, David A.

Published
2024
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11. Consensus statements from the International Society for Heart and Lung Transplantation consensus conference: Heart failure–related cardiogenic shock

Author

Overgaard, Chris, Teuteberg, Jeffrey, Rosner, Carolyn, Nagpal, Dave, Taimeh, Ziad, Abraham, Jacob, Ton, Van-Khue, Drakos, Stavros, Tehrani, Behnam, Bernhardt, Alexander, Meeran, Talha, Douglas Greig, P., Farrero, Marta, Katz, Jason, Luk, Adriana, Bennett, Courtney, Bertolotti, Alejandro, Tedford, Ryan J., Cogswell, Rebecca, Klein, Liviu, Guerrero-Miranda, Cesar Y., Rampersad, Penelope, Potena, Luciano, Boeken, Udo, Copeland, Hannah, Hall, Shelley, González-Costello, José, Kapur, Navin K., Loforte, Antonio, Burkhoff, Daniel, LePrince, Pascal, Gustafsson, Finn, Uriel, Nir, Kataria, Rachna, Arora, Sonali, Masetti, Marco, Saeed, Diyar, Baran, David A., Billia, Filio, Randhawa, Varinder, Cowger, Jennifer A., Barnett, Christopher M., Chih, Sharon, Ensminger, Stephan, Hernandez-Montfort, Jaime, Sinha, Shashank S., Vorovich, Esther, Proudfoot, Alastair, Lim, Hoong Sern, Blumer, Vanessa, Jennings, Douglas L., Garan, A. Reshad, Renedo, Maria Florencia, Hanff, Thomas C., and Kanwar, Manreet K.

Published
2024
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12. Integration of Patient Reported Quality-of-life Data into Risk Assessment in Heart Failure

Author

SIDERIS, KONSTANTINOS, ZHANG, MINGYUAN, WOHLFAHRT, PETER, SIU, ALFONSO F., SHEN, JINCHENG, CARTER, SPENCER, KYRIAKOPOULOS, CHRISTOS P., TALEB, IOSIF, WEVER-PINZON, OMAR, SHAH, KEVIN, SELZMAN, CRAIG H., RODRIGUEZ-CORREA, CARLOS, KAPELIOS, CHRIS, BRINKER, LINA, ALHARETHI, RAMI, HESS, RACHEL, DRAKOS, STAVROS G., STEINBERG, BENJAMIN A., FANG, JAMES C., KFOURY, ABDALLAH G., MELENOVSKY, VOJTECH, GREENE, TOM, SPERTUS, JOHN A., and STEHLIK, JOSEF

Published
2024
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13. Defining cardiac functional recovery in end-stage heart failure at single-cell resolution

Author

Amrute, Junedh M., Lai, Lulu, Ma, Pan, Koenig, Andrew L., Kamimoto, Kenji, Bredemeyer, Andrea, Shankar, Thirupura S., Kuppe, Christoph, Kadyrov, Farid F., Schulte, Linda J., Stoutenburg, Dylan, Kopecky, Benjamin J., Navankasattusas, Sutip, Visker, Joseph, Morris, Samantha A., Kramann, Rafael, Leuschner, Florian, Mann, Douglas L., Drakos, Stavros G., and Lavine, Kory J.

Published
2023
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14. Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis.

Author

Shankar, Thirupura, Ramadurai, Dinesh, Steinhorst, Kira, Sommakia, Salah, Badolia, Rachit, Thodou Krokidi, Aspasia, Calder, Dallen, Navankasattusas, Sutip, Sander, Paulina, Kwon, Oh, Aravamudhan, Aishwarya, Ling, Jing, Dendorfer, Andreas, Xie, Changmin, Kwon, Ohyun, Cheng, Emily, Whitehead, Kevin, Gudermann, Thomas, Richardson, Russel, Sachse, Frank, Schredelseker, Johann, Spitzer, Kenneth, Chaudhuri, Dipayan, and Drakos, Stavros

Subjects
Animals, Apoptosis, Calcium, Calcium Signaling, Cardiomyopathy, Dilated, Heart Failure, Homeostasis, Mice, Mice, Knockout, Mitochondria, Mitochondrial Membranes, Myocardial Contraction, Myocytes, Cardiac, Transcriptome, Voltage-Dependent Anion Channel 2
Abstract

Voltage dependent anion channel 2 (VDAC2) is an outer mitochondrial membrane porin known to play a significant role in apoptosis and calcium signaling. Abnormalities in calcium homeostasis often leads to electrical and contractile dysfunction and can cause dilated cardiomyopathy and heart failure. However, the specific role of VDAC2 in intracellular calcium dynamics and cardiac function is not well understood. To elucidate the role of VDAC2 in calcium homeostasis, we generated a cardiac ventricular myocyte-specific developmental deletion of Vdac2 in mice. Our results indicate that loss of VDAC2 in the myocardium causes severe impairment in excitation-contraction coupling by altering both intracellular and mitochondrial calcium signaling. We also observed adverse cardiac remodeling which progressed to severe cardiomyopathy and death. Reintroduction of VDAC2 in 6-week-old knock-out mice partially rescued the cardiomyopathy phenotype. Activation of VDAC2 by efsevin increased cardiac contractile force in a mouse model of pressure-overload induced heart failure. In conclusion, our findings demonstrate that VDAC2 plays a crucial role in cardiac function by influencing cellular calcium signaling. Through this unique role in cellular calcium dynamics and excitation-contraction coupling VDAC2 emerges as a plausible therapeutic target for heart failure.

Published
2021

16. The 2023 International Society for Heart and Lung Transplantation Guidelines for Mechanical Circulatory Support: A 10- Year Update

Author

Saeed, Diyar, Feldman, David, Banayosy, Aly El, Birks, Emma, Blume, Elizabeth, Cowger, Jennifer, Hayward, Christopher, Jorde, Ulrich, Kremer, Jamila, MacGowan, Guy, Maltais, Simon, Maybaum, Simon, Mehra, Mandeep, Shah, Keyur B., Mohacsi, Paul, Schweiger, Martin, Schroeder, Sarah E., Shah, Palak, Slepian, Marvin, Tops, Laurens F., Alvarez, Paulino, Arabia, Francisco, Aslam, Saima, Benson-Louis, Louis, IV, Birati, Edo, Buchholz, Holger W., Cedars, Ari, Christensen, Dawn, Ciarka, Agnieszka, Coglianese, Erin, Cogswell, Rebecca, Cook, Jennifer, Copeland, Jack, Costello, Jose Gonzalez, Drakos, Stavros G, Eghtesady, Pirooz, Elliot, Tonya, Estep, Jerry D., Eulert-Grehn, Jaime-Juergen, Fabrizio, De Rita, Garbade, Jens, Gelow, Jill, Guglin, Maya, Hernandez-Montfort, Jaime, Horstmanshof, Doug, John, Ranjit, Kanwar, Manreet, Khaliel, Feras, Kim, Gene, Kumar, Sachin, Lavee, Jacob, Leache, Marzia, Leprince, Pascal, Lim, Sern, Loforte, Antonio, Maly, Jiri, Najjar, Samer, Netuka, Ivan, Pamboukian, Salpy V., Patel, Snehal R, Pinney, Sean, Pluym, Christina Vander, Potapov, Evgenij, Robson, Desiree, Rochlani, Yogita, Russell, Stuart, Sandau, Kristin, Sandoval, Elena, Sayer, Gabriel, Schettle, Sarah, Schibilsky, David, Schlöglhofer, Thomas, Schmitto, Jan, Siddique, Aleem, Silvestry, Scott, Slaughter, Mark S, Sun, Benjamin, Takayama, Hiroo, Tedford, Ryan, Teuteberg, Jeffrey J., Ton, Van-Khue, Uriel, Nir, Vierecke, Juliane, Zimpfer, Daniel, and D'Alessandro, David

Published
2023
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17. Insulin receptor substrates differentially exacerbate insulin-mediated left ventricular remodeling

Author

Riehle, Christian, Weatherford, Eric T, Wende, Adam R, Jaishy, Bharat P, Seei, Alec W, McCarty, Nicholas S, Rech, Monika, Shi, Qian, Reddy, Gopireddy R, Kutschke, William J, Oliveira, Karen, Pires, Karla Maria, Anderson, Joshua C, Diakos, Nikolaos A, Weiss, Robert M, White, Morris F, Drakos, Stavros G, Xiang, Yang K, and Abel, E Dale

Subjects
Genetics, Heart Disease, Cardiovascular, Aetiology, 2.1 Biological and endogenous factors, Animals, Cardiomegaly, Humans, Hyperinsulinism, Insulin, Insulin Receptor Substrate Proteins, Insulin Resistance, Mice, Mice, Knockout, Proto-Oncogene Proteins c-akt, Ventricular Remodeling, Cardiology, Heart failure, Insulin signaling
Abstract

Pressure overload (PO) cardiac hypertrophy and heart failure are associated with generalized insulin resistance and hyperinsulinemia, which may exacerbate left ventricular (LV) remodeling. While PO activates insulin receptor tyrosine kinase activity that is transduced by insulin receptor substrate 1 (IRS1), the present study tested the hypothesis that IRS1 and IRS2 have divergent effects on PO-induced LV remodeling. We therefore subjected mice with cardiomyocyte-restricted deficiency of IRS1 (CIRS1KO) or IRS2 (CIRS2KO) to PO induced by transverse aortic constriction (TAC). In WT mice, TAC-induced LV hypertrophy was associated with hyperactivation of IRS1 and Akt1, but not IRS2 and Akt2. CIRS1KO hearts were resistant to cardiac hypertrophy and heart failure in concert with attenuated Akt1 activation. In contrast, CIRS2KO hearts following TAC developed more severe LV dysfunction than WT controls, and this was prevented by haploinsufficiency of Akt1. Failing human hearts exhibited isoform-specific IRS1 and Akt1 activation, while IRS2 and Akt2 activation were unchanged. Kinomic profiling identified IRS1 as a potential regulator of cardioprotective protein kinase G-mediated signaling. In addition, gene expression profiling revealed that IRS1 signaling may promote a proinflammatory response following PO. Together, these data identify IRS1 and Akt1 as critical signaling nodes that mediate LV remodeling in both mice and humans.

Published
2020

21. Abstract 15177: Unloading Reveals a Latent Cardiomyocyte Regeneration Potential in the Human Heart

Author

Derks, Wouter, Rode, Julian, Collin, Sofia, Rost, Fabian, Heinke, Paula, Hariharan, Anjana, Pickel, Lauren, Simonova, Irina, Lázár, Eniko, Graham, Evan, Jashari, Ramadan, Andrä, Michaela, Jeppsson, Anders, Salehpour, Mehran, Alkass, Kanar, Druid, Henrik, Kyriakopoulos, Christos, Taleb, Iosif, Shankar, Thirupura S S, Selzman, Craig, Sadek, Hesham A, Jovinge, Stefan, Brusch, Lutz, Frisen, Jonas, Drakos, Stavros G, and Bergmann, Olaf

Published
2023
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27. Author Correction: Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment

Author

Balderas, Enrique, Eberhardt, David R., Lee, Sandra, Pleinis, John M., Sommakia, Salah, Balynas, Anthony M., Yin, Xue, Parker, Mitchell C., Maguire, Colin T., Cho, Scott, Szulik, Marta W., Bakhtina, Anna, Bia, Ryan D., Friederich, Marisa W., Locke, Timothy M., Van Hove, Johan L. K., Drakos, Stavros G., Sancak, Yasemin, Tristani-Firouzi, Martin, Franklin, Sarah, Rodan, Aylin R., and Chaudhuri, Dipayan

Published
2022
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28. Mitochondrial calcium uniporter stabilization preserves energetic homeostasis during Complex I impairment

Author

Balderas, Enrique, Eberhardt, David R., Lee, Sandra, Pleinis, John M., Sommakia, Salah, Balynas, Anthony M., Yin, Xue, Parker, Mitchell C., Maguire, Colin T., Cho, Scott, Szulik, Marta W., Bakhtina, Anna, Bia, Ryan D., Friederich, Marisa W., Locke, Timothy M., Van Hove, Johan L. K., Drakos, Stavros G., Sancak, Yasemin, Tristani-Firouzi, Martin, Franklin, Sarah, Rodan, Aylin R., and Chaudhuri, Dipayan

Published
2022
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30. Pathophysiologic Vasodilation in Cardiogenic Shock and Its Impact on Mortality.

Author

Chavez, Miguel A., Anderson, McHale, Kyriakopoulos, Christos P., Scott, Monte, Dranow, Elizabeth, Maneta, Eleni, Hamouche, Rana, Taleb, Iosif, Leon, Jacy, Kogelschatz, Benjamin, Goldstein, Jake, Billia, Filio, Baran, David A., Tehran, Behnam, Goodwin, Matt, Selzman, Craig H., Tonna, Joseph E., Fang, James C., Drakos, Stavros G., and Hanff, Thomas C.

Abstract

BACKGROUND: Cardiogenic shock (CS) mortality remains near 40%. In addition to inadequate cardiac output, patients with severe CS may exhibit vasodilation. We aimed to examine the prevalence and consequences of vasodilation in CS. METHODS: We analyzed all patients hospitalized at a CS referral center who were diagnosed with CS stages B to E and did not have concurrent sepsis or recent cardiac surgery. Vasodilation was defined by lower systemic vascular resistance (SVR), higher norepinephrine equivalent dose, or a blunted SVR response to pressors. Threshold SVR values were determined by their relation to 14-day mortality in spline models. The primary outcome was death within 14 days of CS onset in multivariable-adjusted Cox models. RESULTS: This study included 713 patients with a mean age of 60 years and 27% females; 14-day mortality was 28%, and 38% were vasodilated. The median SVR was 1308 dynes•s•cm−5 (interquartile range, 870–1652), median norepinephrine equivalent was 0.11 µg/kg per minute (interquartile range, 0–0.2), and 28% had a blunted pressor response. Each 100-dynes•s•cm−5 decrease in SVR below 800 was associated with 20% higher mortality (adjusted hazard ratio, 1.23; P=0.004). Each 0.1-µg/kg per minute increase in norepinephrine equivalent dose was associated with 15% higher mortality (adjusted hazard ratio, 1.12; P<0.001). A blunted pressor response was associated with a nearly 2-fold mortality increase (adjusted hazard ratio, 1.74; P=0.003). CONCLUSIONS: Pathophysiologic vasodilation is prevalent in CS and independently associated with an increased risk of death. CS vasodilation can be identified by SVR <800 dynes•s•cm−5, high doses of pressors, or a blunted SVR response to pressors. Additional studies exploring mechanisms and treatments for CS vasodilation are needed. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Clinical Characteristics and Outcomes of Patients Suffering Acute Decompensated Heart Failure Complicated by Cardiogenic Shock.

Author

Kyriakopoulos, Christos P., Sideris, Konstantinos, Taleb, Iosif, Maneta, Eleni, Hamouche, Rana, Tseliou, Eleni, Chong Zhang, Presson, Angela P., Dranow, Elizabeth, Shah, Kevin S., Jones, Tara L., Fang, James C., Stehlik, Josef, Selzman, Craig H., Goodwin, Matthew L., Tonna, Joseph E., Hanff, Thomas C., and Drakos, Stavros G.

Abstract

BACKGROUND: Cardiogenic shock (CS) can stem from multiple causes and portends poor prognosis. Prior studies have focused on acute myocardial infarction-CS; however, acute decompensated heart failure (ADHF)-CS accounts for most cases. We studied patients suffering ADHF-CS to identify clinical factors, early in their trajectory, associated with a higher probability of successful outcomes. METHODS: Consecutive patients with CS were evaluated (N=1162). We studied patients who developed ADHF-CS at our hospital (N=562). Primary end point was native heart survival (NHS), defined as survival to discharge without receiving advanced HF therapies. Secondary end points were adverse events, survival, major cardiac interventions, and hospital readmissions within 1 year following index hospitalization discharge. Association of clinical data with NHS was analyzed using logistic regression. RESULTS: Overall, 357 (63.5%) patients achieved NHS, 165 (29.2%) died, and 41 (7.3%) were discharged post advanced HF therapies. Of 398 discharged patients (70.8%), 303 (53.9%) were alive at 1 year. Patients with NHS less commonly suffered cardiac arrest, underwent intubation or pulmonary artery catheter placement, or received temporary mechanical circulatory support, had better hemodynamic and echocardiographic profiles, and had a lower vasoactive-inotropic score at shock onset. Bleeding, hemorrhagic stroke, hemolysis in patients with mechanical circulatory support, and acute kidney injury requiring renal replacement therapy were less common compared with patients who died or received advanced HF therapies. After multivariable adjustments, clinical variables associated with NHS likelihood included younger age, history of systemic hypertension, absence of cardiac arrest or acute kidney injury requiring renal replacement therapy, lower pulmonary capillary wedge pressure and vasoactive-inotropic score, and higher tricuspid annular plane systolic excursion at shock onset (all P<0.05). CONCLUSIONS: By studying contemporary patients with ADHF-CS, we identified clinical factors that can inform clinical management and provide future research targets. Right ventricular function, renal function, pulmonary artery catheter placement, and type and timing of temporary mechanical circulatory support warrant further investigation to improve outcomes of this devastating condition. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Hospital Readmissions in Patients Supported with Durable Centrifugal-Flow Left Ventricular Assist Devices

Author

Kyriakopoulos, Christos P., primary, Selzman, Craig H., additional, Giannouchos, Theodoros V., additional, Mylavarapu, Rohan, additional, Sideris, Konstantinos, additional, Elmer, Ashley, additional, Vance, Nathan, additional, Hanff, Thomas C., additional, Kagawa, Hiroshi, additional, Stehlik, Josef, additional, Drakos, Stavros G., additional, and Goodwin, Matthew L., additional

Published
2024
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33. Bridge‐to‐transplant temporary mechanical circulatory support and risk of allosensitization

Author

Sideris, Konstantinos, primary, Lázár‐Molnár, Eszter, additional, Kyriakopoulos, Christos P., additional, Taleb, Iosif, additional, Hurst, Denise, additional, Ugolini, Sharon, additional, Selzman, Craig H., additional, Brinker, Lina, additional, Drakos, Stavros G., additional, Tonna, Joseph E., additional, Geer, Laura, additional, Goodwin, Matthew L., additional, Wever‐Pinzon, Omar, additional, Hanff, Thomas C., additional, Fang, James C., additional, Carter, Spencer, additional, and Stehlik, Josef, additional

Published
2024
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34. Evaluation of renal sodium handling in heart failure with preserved ejection fraction: A pilot study

Author

Agarwal, Adhish, primary, Beddhu, Srinivasan, additional, Boucher, Robert, additional, Rao, Veena, additional, Ramkumar, Nirupama, additional, Rodan, Aylin R., additional, Fang, Jacob, additional, Wynne, Brandi M., additional, Drakos, Stavros G., additional, Hanff, Thomas, additional, Cheung, Alfred K., additional, and Fang, James C., additional

Published
2024
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35. Management and Outcomes of Cardiogenic Shock in Cardiac ICUs With Versus Without Shock Teams

Author

Papolos, Alexander I., Kenigsberg, Benjamin B., Berg, David D., Alviar, Carlos L., Bohula, Erin, Burke, James A., Carnicelli, Anthony P., Chaudhry, Sunit-Preet, Drakos, Stavros, Gerber, Daniel A., Guo, Jianping, Horowitz, James M., Katz, Jason N., Keeley, Ellen C., Metkus, Thomas S., Nativi-Nicolau, Jose, Snell, Jeffrey R., Sinha, Shashank S., Tymchak, Wayne J., Van Diepen, Sean, Morrow, David A., and Barnett, Christopher F.

Published
2021
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36. Distinct Transcriptomic and Proteomic Profile Specifies Patients Who Have Heart Failure With Potential of Myocardial Recovery on Mechanical Unloading and Circulatory Support

Author

Drakos, Stavros G., Badolia, Rachit, Makaju, Aman, Kyriakopoulos, Christos P., Wever-Pinzon, Omar, Tracy, Christopher M., Bakhtina, Anna, Bia, Ryan, Parnell, Timothy, Taleb, Iosif, Ramadurai, Dinesh K.A., Navankasattusas, Sutip, Dranow, Elizabeth, Hanff, Thomas C., Tseliou, Eleni, Shankar, Thirupura S., Visker, Joseph, Hamouche, Rana, Stauder, Elizabeth L., Caine, William T., Alharethi, Rami, Selzman, Craig H., and Franklin, Sarah

Published
2023
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37. The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure

Author

Cluntun, Ahmad A., Badolia, Rachit, Lettlova, Sandra, Parnell, K. Mark, Shankar, Thirupura S., Diakos, Nikolaos A., Olson, Kristofor A., Taleb, Iosif, Tatum, Sean M., Berg, Jordan A., Cunningham, Corey N., Van Ry, Tyler, Bott, Alex J., Krokidi, Aspasia Thodou, Fogarty, Sarah, Skedros, Sophia, Swiatek, Wojciech I., Yu, Xuejing, Luo, Bai, Merx, Shannon, Navankasattusas, Sutip, Cox, James E., Ducker, Gregory S., Holland, William L., McKellar, Stephen H., Rutter, Jared, and Drakos, Stavros G.

Published
2021
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39. Abstract 15761: SMYD1 Regulates OPA1-Mediated Cristae Remodeling and Supercomplex Formation to Protect From Ischemic Injury

Author

Szulik, Marta, Valdez, Steven, Walsh, Maureen, Davis, Kathryn, Bia, Ryan, Horiuchi, Emilee, OʼVery, Sean, Nicolova, Linda, Sheikh, Hanin, Hickenlooper, Samuel, Creed, Magnus, Miller, Mickey R, Wang, Li, Garcia-Llano, June, Tracy, Chris, Drakos, Stavros G, Funai, Katsuhiko, Chaudhuri, Dipayan, Boudina, Sihem, and Franklin, Sarah

Published
2022
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41. Abstract 11629: Multicenter Development and Validation of a Machine Learning Risk Model to Predict Right Ventricular Failure Following Mechanical Circulatory Support: The STOP-RVF Score

Author

Kyriakopoulos, Christos P, Taleb, Iosif, Ijaz, Naila, Demertzis, Zachary, Peruri, Adithya, Wever-Pinzon, Omar, Koliopoulou, Antigone G, Bonios, Michael J, Hanff, Thomas C, Dranow, Elizabeth, Giannouchos, Theodoros V, Sideris, Konstantinos, Nelson, Marisca, Elmer, Ashley, Tang, Daniel, Nemeh, Hassan, Stehlik, Josef, Fang, James C, Selzman, Craig H, Alharethi, Rami, Caine, William, Cowger, Jennifer, Shah, Palak, and Drakos, Stavros G

Published
2022
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43. Abstract 11588: Multicenter Development and Validation of a Machine Learning Model to Predict Myocardial Recovery During LVAD Support: The UCAR Score

Author

Kyriakopoulos, Christos P, Taleb, Iosif, Wever-Pinzon, Omar, Selzman, Craig H, Kfoury, Abdallah, Bonios, Michael J, Wever-Pinzon, James, Yin, Michael Y, Tseliou, Eleni, Stehlik, Josef, Alharethi, Rami, Caine, William, Fang, James C, Koliopoulou, Antigone G, Sideris, Konstantinos, Nelson, Marisca, Elmer, Ashley, Dranow, Elizabeth, Singh, Ramesh, Psotka, Mitchell, Birks, Emma J, Slaughter, Mark S, Koenig, Steven, Kyvernitakis, Andreas, Hoffman, Karlee, Guglin, Maya, Kotter, John, Campbell, Kenneth S, Silvestry, Scott C, Vidic, Andrija, Raval, Nirav, Cowger, Jennifer, Kanwar, Manreet, Shah, Palak, and Drakos, Stavros G

Published
2022
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45. Learnings from the 2024 Utah Cardiac Recovery Symposium: A Roadmap for the Field of Myocardial Recovery.

Author

KRISHNAMOORTHI, MUTHU KUMAR, SIDERIS, KONSTANTINOS, BHIMARAJ, ARVIND, and DRAKOS, STAVROS G.

Subjects
GENETIC regulation, HEART metabolism, CARDIAC arrest, GENOME editing, CARDIOPULMONARY resuscitation, HEART failure
Abstract

The 12th annual Utah Cardiac Recovery Symposium (U-CARS) in 2024 continued its mission to advance cardiac recovery by uniting experts across various fields. The symposium featured key presentations on cutting-edge topics such as CRISPR gene editing for heart failure, guideline-directed medical therapy for heart failure (HF) with improved/recovered ejection fraction (HFimpEF), the role of extracorporeal cardiopulmonary resuscitation (ECPR) in treating cardiac arrest, and others. Discussions explored genetic and metabolic contributions to HF, emphasized the importance of maintaining pharmacotherapy in HFimpEF to prevent relapse, and identified future research directions including refining ECPR protocols, optimizing patient selection, and leveraging genetic insights to enhance therapeutic strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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46. Impact of Diabetes and Glycemia on Cardiac Improvement and Adverse Events Following Mechanical Circulatory Support.

Author

Kyriakopoulos, Christos P., Taleb, Iosif, Tseliou, Eleni, Sideris, Konstantinos, Hamouche, Rana, Maneta, Eleni, Nelson, Marisca, Krauspe, Ethan, Selko, Sean, Visker, Joseph R., Dranow, Elizabeth, Goodwin, Matthew L., Alharethi, Rami, Wever Pinzon, Omar, Fang, James C., Stehlik, Josef, Selzman, Craig H., Hanff, Thomas C., and Drakos, Stavros G.

Published
2024
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47. American Heart Association Cardiogenic Shock Registry: Design and Implementation.

Author

Morrow, David A., Jessup, Mariell, Abraham, William T., Acker, Michael, Aringo, Angeline, Batchelor, Wayne, Chikwe, Joanna, Costello, Shaina, Drakos, Stavros G., Farmer, Steven, Gelijns, Annetine, Gillette, Nicole, Hochman, Judith S., Isler, Maria, Kapur, Navin K., Kilic, Arman, Kormos, Robert, Lewis, Eldrin F., Lindenfeld, JoAnn, and Lombardi, Pierluca

Abstract

BACKGROUND: Cardiogenic shock is a morbid complication of heart disease that claims the lives of more than 1 in 3 patients presenting with this syndrome. Supporting a unique collaboration across clinical specialties, federal regulators, payors, and industry, the American Heart Association volunteers and staff have launched a quality improvement registry to better understand the clinical manifestations of shock phenotypes, and to benchmark the management patterns, and outcomes of patients presenting with cardiogenic shock to hospitals across the United States. METHODS: Participating hospitals will enroll consecutive hospitalized patients with cardiogenic shock, regardless of etiology or severity. Data are collected through individual reviews of medical records of sequential adult patients with cardiogenic shock. The electronic case record form was collaboratively designed with a core minimum data structure and aligned with Shock Academic Research Consortium definitions. This registry will allow participating health systems to evaluate patientlevel data including diagnostic approaches, therapeutics, use of advanced monitoring and circulatory support, processes of care, complications, and in-hospital survival. Participating sites can leverage these data for onsite monitoring of outcomes and benchmarking versus other institutions. The registry was concomitantly designed to provide a high-quality longitudinal research infrastructure for pragmatic randomized trials as well as translational, clinical, and implementation research. An aggregate deidentified data set will be made available to the research community on the American Heart Association's Precision Medicine Platform. On March 31, 2022, the American Heart Association Cardiogenic Shock Registry received its first clinical records. At the time of this submission, 100 centers are participating. CONCLUSIONS: The American Heart Association Cardiogenic Shock Registry will serve as a resource using consistent data structure and definitions for the medical and research community to accelerate scientific advancement through shared learning and research resulting in improved quality of care and outcomes of shock patients. [ABSTRACT FROM AUTHOR]

Published
2024
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49. FGF21 (Fibroblast Growth Factor 21) Defines a Potential Cardiohepatic Signaling Circuit in End-Stage Heart Failure

Author

Sommakia, Salah, Almaw, Naredos H., Lee, Sandra H., Ramadurai, Dinesh K.A., Taleb, Iosif, Kyriakopoulos, Christos P., Stubben, Chris J., Ling, Jing, Campbell, Robert A., Alharethi, Rami A., Caine, William T., Navankasattusas, Sutip, Hoareau, Guillaume L., Abraham, Anu E., Fang, James C., Selzman, Craig H., Drakos, Stavros G., and Chaudhuri, Dipayan

Published
2021
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50. Advanced Heart Failure: Therapeutic Options and Challenges in the Evolving Field of Left Ventricular Assist Devices

Author

Antonopoulos, Michael, primary, Bonios, Michael J., additional, Dimopoulos, Stavros, additional, Leontiadis, Evangelos, additional, Gouziouta, Aggeliki, additional, Kogerakis, Nektarios, additional, Koliopoulou, Antigone, additional, Elaiopoulos, Dimitris, additional, Vlahodimitris, Ioannis, additional, Chronaki, Maria, additional, Chamogeorgakis, Themistocles, additional, Drakos, Stavros G., additional, and Adamopoulos, Stamatis, additional

Published
2024
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