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1. Oncoplastic and reconstructive surgery in SENONETWORK Italian breast centers: lights and shadows

Author

Abbonante, Francesco, Lamanna, Ginevra, Lombardi, Augusto, Vischi, Silvio, Orzalesi, Lorenzo, Angiolucci, Giovanni, Bozzo, Samantha, Pizzorno, Laura, Ballardini, Bettina, Barbero, Maggiorino, Barellini, Leonardo, Battaglia, Claudio, Reggiani, Luisa, Santi, Caterina, Biglio, Nicoletta, Bortul, Marina, Burelli, Paolo, Busani, Massimo, Cabula, Roberta, Cagossi, Katia, Fontanarosa, Vito Maria, Catalano, Francesca, Cedolini, Carla, Ciuffreda, Luigi, Corsi, Fabio, Custodero, Olindo, Mori, Stefano, De Vita, Roy, Defilippi, Loredana, Marcuzzi, Samantha, Drago, Stefano, Battista, Giovanni, Burgoa, Loredana, Cristofolini, Paolo, Romanucci, Giovanna, Loreti, Andrea, Prosperi, Valerio, Carcoforo, Paolo, Franzini, Patrizia Fulvia, Frittelli, Patrizia, Perniciaro, Giuseppe, Generali, Daniele, Giordano, Monica, Riccardo, Giovanazzi, Grossi, Simona, Huscher, Alessandra, La Torre, Giuseppe, Lolli, Gianfranco, Magni, Carla, Mancini, Stefano, Galli, Lorenzo, Di Leone, Alba, Massarut, Samuele, Massocco, Alberto, Cramarossa, Monica, Meneghini, Graziano, Fabiocchi, Luca, Miglietta, Anna Maria, Millo, Francesco, Ciabattoni, Antonella, Pellini, Francesca, Moschetta, Marco, Musolino, Antonino, Palli, Dante, Pagura, Giulia, Pieraccini, Mariagrazia, Marenco, Davide, Polato, Romano, Renne, Maria, Ressa, Cosmo Maurizio, Ricci, Fabio, Ridolfo, Raffaella, Rovera, Francesca Angela, Barberini, Francesco, Vinciguerra, Marina, Furci, Marco, Sciamannini, Maria, Gianquinto, Daniela, Petrucci, Silvia, Della Valle, Angelica, Stancampiano, Pietra, Lippi, Andrea, Tazzioli, Giovanni, Lombardi, Davide, Trunfio, Martino, Valieri, Luca, Vecchio, Carlo, Veronesi, Paolo, Grilz, Gretha, Ghilli, Matteo, Lisa, Andrea Vittorio Emanuele, Salgarello, Marzia, Papa, Giovanni, Rietjens, Mario, Folli, Secondo, Curcio, Annalisa, Ferrari, Guglielmo, Caruso, Francesco, Altomare, Vittorio, Friedman, Daniele, De Santis, Maria Carmen, De Rose, Fiorenza, Meduri, Bruno, De Felice, Francesca, Marino, Lorenza, Cucciarelli, Francesca, Montemezzi, Stefania, Panizza, Pietro, Belli, Paolo, Caumo, Francesca, Vinci, Valeriano, De Santis, Giorgio, Klinger, Marco, and Roncella, Manuela

Published
2024
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2. Oncoplastic and reconstructive surgery in SENONETWORK Italian breast centers: lights and shadows

Author

Ghilli, Matteo, primary, Lisa, Andrea Vittorio Emanuele, additional, Salgarello, Marzia, additional, Papa, Giovanni, additional, Rietjens, Mario, additional, Folli, Secondo, additional, Curcio, Annalisa, additional, Ferrari, Guglielmo, additional, Caruso, Francesco, additional, Altomare, Vittorio, additional, Friedman, Daniele, additional, De Santis, Maria Carmen, additional, De Rose, Fiorenza, additional, Meduri, Bruno, additional, De Felice, Francesca, additional, Marino, Lorenza, additional, Cucciarelli, Francesca, additional, Montemezzi, Stefania, additional, Panizza, Pietro, additional, Belli, Paolo, additional, Caumo, Francesca, additional, Vinci, Valeriano, additional, De Santis, Giorgio, additional, Klinger, Marco, additional, Roncella, Manuela, additional, Abbonante, Francesco, additional, Lamanna, Ginevra, additional, Lombardi, Augusto, additional, Vischi, Silvio, additional, Orzalesi, Lorenzo, additional, Angiolucci, Giovanni, additional, Bozzo, Samantha, additional, Pizzorno, Laura, additional, Ballardini, Bettina, additional, Barbero, Maggiorino, additional, Barellini, Leonardo, additional, Battaglia, Claudio, additional, Reggiani, Luisa, additional, Santi, Caterina, additional, Biglio, Nicoletta, additional, Bortul, Marina, additional, Burelli, Paolo, additional, Busani, Massimo, additional, Cabula, Roberta, additional, Cagossi, Katia, additional, Fontanarosa, Vito Maria, additional, Catalano, Francesca, additional, Cedolini, Carla, additional, Ciuffreda, Luigi, additional, Corsi, Fabio, additional, Custodero, Olindo, additional, Mori, Stefano, additional, De Vita, Roy, additional, Defilippi, Loredana, additional, Marcuzzi, Samantha, additional, Drago, Stefano, additional, Battista, Giovanni, additional, Burgoa, Loredana, additional, Cristofolini, Paolo, additional, Romanucci, Giovanna, additional, Loreti, Andrea, additional, Prosperi, Valerio, additional, Carcoforo, Paolo, additional, Franzini, Patrizia Fulvia, additional, Frittelli, Patrizia, additional, Perniciaro, Giuseppe, additional, Generali, Daniele, additional, Giordano, Monica, additional, Riccardo, Giovanazzi, additional, Grossi, Simona, additional, Huscher, Alessandra, additional, La Torre, Giuseppe, additional, Lolli, Gianfranco, additional, Magni, Carla, additional, Mancini, Stefano, additional, Galli, Lorenzo, additional, Di Leone, Alba, additional, Massarut, Samuele, additional, Massocco, Alberto, additional, Cramarossa, Monica, additional, Meneghini, Graziano, additional, Fabiocchi, Luca, additional, Miglietta, Anna Maria, additional, Millo, Francesco, additional, Ciabattoni, Antonella, additional, Pellini, Francesca, additional, Moschetta, Marco, additional, Musolino, Antonino, additional, Palli, Dante, additional, Pagura, Giulia, additional, Pieraccini, Mariagrazia, additional, Marenco, Davide, additional, Polato, Romano, additional, Renne, Maria, additional, Ressa, Cosmo Maurizio, additional, Ricci, Fabio, additional, Ridolfo, Raffaella, additional, Rovera, Francesca Angela, additional, Barberini, Francesco, additional, Vinciguerra, Marina, additional, Furci, Marco, additional, Sciamannini, Maria, additional, Gianquinto, Daniela, additional, Petrucci, Silvia, additional, Della Valle, Angelica, additional, Stancampiano, Pietra, additional, Lippi, Andrea, additional, Tazzioli, Giovanni, additional, Lombardi, Davide, additional, Trunfio, Martino, additional, Valieri, Luca, additional, Vecchio, Carlo, additional, Veronesi, Paolo, additional, and Grilz, Gretha, additional

Published
2024
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12. Erratum to: Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node, intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase

Author

Di Filippo, Franco, primary, Di Filippo, Simona, additional, Ferrari, Anna Maria, additional, Antonetti, Raffaele, additional, Battaglia, Alessandro, additional, Becherini, Francesca, additional, Bernet, Laia, additional, Boldorini, Renzo, additional, Bouteille, Catherine, additional, Buglioni, Simonetta, additional, Burelli, Paolo, additional, Cano, Rafael, additional, Canzonieri, Vincenzo, additional, Chiodera, Pierluigi, additional, Cirilli, Alfredo, additional, Coppola, Luigi, additional, Drago, Stefano, additional, Di Tommaso, Luca, additional, Fenaroli, Privato, additional, Franchini, Roberto, additional, Gianatti, Andrea, additional, Giannarelli, Diana, additional, Giardina, Carmela, additional, Godey, Florence, additional, Grassi, Massimo M., additional, Grassi, Giuseppe B., additional, Laws, Siobhan, additional, Massarut, Samuele, additional, Naccarato, Giuseppe, additional, Natalicchio, Maria Iole, additional, Orefice, Sergio, additional, Palmieri, Fabrizio, additional, Perin, Tiziana, additional, Roncella, Manuela, additional, Roncalli, Massimo G., additional, Rulli, Antonio, additional, Sidoni, Angelo, additional, Tinterri, Corrado, additional, Truglia, Maria C., additional, and Sperduti, Isabella, additional

Published
2017
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13. Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node, intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase

Author

Di Filippo, Franco, primary, Di Filippo, Simona, additional, Ferrari, Anna Maria, additional, Antonetti, Raffaele, additional, Battaglia, Alessandro, additional, Becherini, Francesca, additional, Bernet, Laia, additional, Boldorini, Renzo, additional, Bouteille, Catherine, additional, Buglioni, Simonetta, additional, Burelli, Paolo, additional, Cano, Rafael, additional, Canzonieri, Vincenzo, additional, Chiodera, Pierluigi, additional, Cirilli, Alfredo, additional, Coppola, Luigi, additional, Drago, Stefano, additional, Di Tommaso, Luca, additional, Fenaroli, Privato, additional, Franchini, Roberto, additional, Gianatti, Andrea, additional, Giannarelli, Diana, additional, Giardina, Carmela, additional, Godey, Florence, additional, Grassi, Massimo M., additional, Grassi, Giuseppe B., additional, Laws, Siobhan, additional, Massarut, Samuele, additional, Naccarato, Giuseppe, additional, Natalicchio, Maria Iole, additional, Orefice, Sergio, additional, Palmieri, Fabrizio, additional, Perin, Tiziana, additional, Roncella, Manuela, additional, Roncalli, Massimo G., additional, Rulli, Antonio, additional, Sidoni, Angelo, additional, Tinterri, Corrado, additional, Truglia, Maria C., additional, and Sperduti, Isabella, additional

Published
2016
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14. Platelet cyclic GMP levels in unstable angina and myocardial infarction

Author

Trevi Gp, Anna Capizzi, Luisella Carrieri, Drago Stefano, Paglia I, Serena Bergerone, Massimo Pistono, Gianpiero Pescarmona, Amalia Bosia, and Marcella Ferri

Subjects
Blood Platelets, Male, Nitroprusside, medicine.medical_specialty, Platelet Aggregation, Population, Myocardial Infarction, Radioimmunoassay, Stimulation, Nitric Oxide, Nitric oxide, Angina Pectoris, chemistry.chemical_compound, Internal medicine, medicine, Humans, Platelet, Myocardial infarction, education, Cyclic GMP, Aged, Aged, 80 and over, education.field_of_study, business.industry, Unstable angina, Hematology, General Medicine, Middle Aged, medicine.disease, Endocrinology, chemistry, Guanylate Cyclase, Case-Control Studies, Cardiology, Female, Sodium nitroprusside, business, medicine.drug
Abstract

Several studies showed that there is a state of platelet hyperactivaction in patients with coronary syndrome: the aim of this study is to investigate if the platelet nitric oxide-cyclicGMP (NO-cGMP) pathway, that regulates platelet aggregation is altered in patients with unstable angina (UA) and acute myocardial infarction (AMI).Population included 11 patients with UA, 12 patients with AMI and 23 controls. Platelet cGMP was measured by a radioimmunoassay kit, under basal conditions and after stimulation with sodium nitroprusside (SNP), which maximally stimulates soluble guanylate cyclase (sGC), used as an indirect measurement of active sGC. Basal platelet cGMP values were significantly (P0.001) higher in patients with UA and AMI than in controls (UA, 1089 +/- 412 pmol/10(10) platelets; AMI, 1071 +/- 507 pmol/10(10) platelets; controls, 492 +/- 201 pmol/10(10) platelets). The final cGMP level reached after SNP stimulation was significantly more elevated in UA, compared with both AMI (P0.05) and controls (P0.02) (UA, 4428 +/- 2723 pmol/10(10) platelets; AMI, 2728 +/- 655 pmol/10(10) platelets; controls, 2772 +/- 1031 pmol/10(10) platelets); on the contrary no significant difference between AMI and controls was observed.Basal platelet cGMP is significantly higher in both UA and AMI groups. This observation suggests that: (1) platelet-derived NO synthesis may be enhanced inUA and AMI, due to increase of intraplatelet calcium level and of platelet cNOS activation; (2) platelets from UA and AMI patients are continuously stimulated by the high-level NO production due to increased iNOS expression. As far as SNP-dependent cGMP production is concerned, UA and AMI behave as two separate conditions. SNP-stimulated activity in UA is higher than in controls, while a loss of functional sGC is observed in AMI.

Published
2002

16. Elaboration of a nomogram to predict nonsentinel node status in breast cancer patients with positive sentinel node, intraoperatively assessed with one step nucleic amplification: Retrospective and validation phase

Author

Pierluigi Chiodera, Corrado Tinterri, Francesca Becherini, Giuseppe B. Grassi, Maria Iole Natalicchio, Samuele Massarut, Luca Di Tommaso, Florence Godey, Fabrizio Palmieri, Angelo Sidoni, Laia Bernet, Rafael Cano, Simonetta Buglioni, Sergio Orefice, Massimo Grassi, Luigi Michele Coppola, Roberto Franchini, Vincenzo Canzonieri, Isabella Sperduti, Tiziana Perin, Franco Di Filippo, Raffaele Antonetti, Privato Fenaroli, Carmela Giardina, Stefano Drago, Alessandro Battaglia, Catherine Bouteille, Andrea Gianatti, Simona Di Filippo, Paolo Burelli, Anna Maria Ferrari, G. Naccarato, Manuela Roncella, Siobhan Laws, Antonio Rulli, Massimo Roncalli, Renzo Boldorini, Diana Giannarelli, Maria C. Truglia, Alfredo Cirilli, Di Filippo, Franco, Di Filippo, Simona, Ferrari, Anna Maria, Antonetti, Raffaele, Battaglia, Alessandro, Becherini, Francesca, Bernet, Laia, Boldorini, Renzo, Bouteille, Catherine, Buglioni, Simonetta, Burelli, Paolo, Cano, Rafael, Canzonieri, Vincenzo, Chiodera, Pierluigi, Cirilli, Alfredo, Coppola, Luigi, Drago, Stefano, Di Tommaso, Luca, Fenaroli, Privato, Franchini, Roberto, Gianatti, Andrea, Giannarelli, Diana, Giardina, Carmela, Godey, Florence, Grassi, Massimo M., Grassi, Giuseppe B., Laws, Siobhan, Massarut, Samuele, Naccarato, Giuseppe, Natalicchio, Maria Iole, Orefice, Sergio, Palmieri, Fabrizio, Perin, Tiziana, Roncella, Manuela, Roncalli, Massimo G., Rulli, Antonio, Sidoni, Angelo, Tinterri, Corrado, Truglia, Maria C., and Sperduti, Isabella

Subjects
0301 basic medicine, medicine.medical_specialty, Cancer Research, Non Sentinel Node status, Sentinel lymph node, Gene Dosage, Nomogram, OSNA method, CK19 mRNA number copies, Breast Neoplasms, 03 medical and health sciences, Intraoperative Period, 0302 clinical medicine, Breast cancer, Theoretical, Models, medicine, Humans, Lymph node, Retrospective Studies, Keratin-19, Receiver operating characteristic, business.industry, Research, Axillary Lymph Node Dissection, Nucleic acid amplification technique, Sentinel node, medicine.disease, Surgery, Nomograms, 030104 developmental biology, medicine.anatomical_structure, ROC Curve, Oncology, Female, Lymph Node Excision, Lymphatic Metastasis, Models, Theoretical, Neoplasm Grading, Neoplasm Micrometastasis, Nucleic Acid Amplification Techniques, Non Sentinel Node statu, 030220 oncology & carcinogenesis, Radiology, business
Abstract

Background: Tumor-positive sentinel lymph node (SLN) biopsy results in a risk of non sentinel node metastases in micro-and macro-metastases ranging from 20 to 50%, respectively. Therefore, most patients underwent unnecessary axillary lymph node dissections. We have previously developed a mathematical model for predicting patient-specific risk of non sentinel node (NSN) metastases based on 2460 patients. The study reports the results of the validation phase where a total of 1945 patients were enrolled, aimed at identifying a tool that gives the possibility to the surgeon to choose intraoperatively whether to perform or not axillary lymph node dissection (ALND). Methods: The following parameters were recorded: Clinical: hospital, age, medical record number; Bio pathological: Tumor (T) size stratified in quartiles, grading (G), histologic type, lymphatic/vascular invasion (LVI), ER-PR status, Ki 67, molecular classification (Luminal A, Luminal B, HER-2 Like, Triple negative); Sentinel and non-sentinel node related: Number of NSNs removed, number of positive NSNs, cytokeratin 19 (CK19) mRNA copy number of positive sentinel nodes stratified in quartiles. A total of 1945 patients were included in the database. All patient data were provided by the authors of this paper. Results: The discrimination of the model quantified with the area under the receiver operating characteristics (ROC) curve (AUC), was 0.65 and 0.71 in the validation and retrospective phase, respectively. The calibration determines the distance between predicted outcome and actual outcome. The mean difference between predicted/observed was 2.3 and 6.3% in the retrospective and in the validation phase, respectively. The two values are quite similar and as a result we can conclude that the nomogram effectiveness was validated. Moreover, the ROC curve identified in the risk category of 31% of positive NSNs, the best compromise between false negative and positive rates i.e. when ALND is unnecessary (< 31%) or recommended (> 31%). Conclusions: The results of the study confirm that OSNA nomogram may help surgeons make an intraoperative decision on whether to perform ALND or not in case of positive sentinel nodes, and the patient to accept this decision based on a reliable estimation on the true percentage of NSN involvement. The use of this nomogram achieves two main gools: 1) the choice of the right treatment during the operation, 2) to avoid for the patient a second surgery procedure.

Published
2016

17. [Sentinel lymph node biopsy in breast cancer. Experience of the Rome Breast Cancer Study Group].

Author

Fortunato L, Drago S, Vitelli CE, Santoni M, Gucciardo G, Cabassi A, Farina M, La Pinta M, Remedi M, Pagano G, Silipod T, Terribile D, Stagnitto D, and Grassi GB

Subjects
Adult, Aged, Aged, 80 and over, Axilla surgery, Breast Neoplasms diagnostic imaging, Coloring Agents administration & dosage, Evans Blue administration & dosage, Female, Follow-Up Studies, Humans, Injections, Intradermal, Lymph Nodes diagnostic imaging, Middle Aged, Neoplasm Staging, Radionuclide Imaging, Radiopharmaceuticals administration & dosage, Reproducibility of Results, Retrospective Studies, Rome, Technetium Tc 99m Aggregated Albumin administration & dosage, Breast Neoplasms pathology, Breast Neoplasms surgery, Lymph Nodes pathology, Sentinel Lymph Node Biopsy
Abstract

We report our multicentric experience with sentinel lymph node biopsy for breast cancer patients. Patients with breast cancer operated on from January 1999 to March 2005 in 6 different institutions in the Rome area were retrospectively reviewed. All patients gave written informed consent. 1440 consecutive patients were analysed, with a median age of 59 years (range: 33-81) and a median tumour diameter of 1.3 cm (range: 0.1-5). Patients underwent lymphatic mapping with Tc99 nanocolloid (N = 701; 49%), with Evans Blue (N = 70; 5%), or with a combined injection (N = 669, 46%). The majority of patients were mapped with an intradermal or subdermal injection (N = 1193; 84%), while an intraparenchymal or peritumoral injection was used in 41 (3%) and 206 patients (13%), respectively. Sentinel lymph nodes were identified in 1374/1440 cases (95.4%), and 2075 sentinel lymph nodes were analysed (average 1.5/patient). A total of 9305 additional non-sentinel lymph-nodes were removed (median 6/patient). Correlations between sentinel lymph nodes and final lymph node status were found in 1355/1374 cases (98.6%). There were 19 false-negative cases (5%). Lymph node metastases were diagnosed in 325 patients (24%). In this group, micrometastases (< 2 mm in diameter) were diagnosed in 103 cases (7.6%). Additionally, isolated tumour cells were reported in 61 patients (4,5%). In positive cases, additional metastases in non-sentinel lymph-nodes were identified in 117/325 cases after axillary dissection (36%). Axillary dissection was avoided in 745/1440 patients (52%). At a median follow-up of 36 months, only 1 axillary recurrence has been reported. Sentinel lymph node biopsy improves staging in women with breast cancer because it is accurate and reproducible, and allows detection of micrometastases and isolated tumour cells that would otherwise be missed. Our multicentric study confirms that this is the preferred axillary staging procedure in women with breast cancer.

Published
2006

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