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3. Comparative Efficacy of High-Dose Dexamethasone Versus Methylprednisolone in Coronavirus Disease 2019 (COVID-19)-Associated Acute Respiratory Distress Syndrome

Author

Kovacevic, Pedja, primary, Malic, Jovana, additional, Kovacevic, Tijana, additional, Dragic, Sasa, additional, Zlojutro, Biljana, additional, Jandric, Milka, additional, Momcicevic, Danica, additional, Cancarevic-Djajic, Branka, additional, Skrbic, Ranko, additional, and Rizwan, M. Zeeshan, additional

Published
2024
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9. Characteristics and Outcomes of Critically Ill Pregnant/Postpartum Women with COVID-19 Pneumonia in Western Balkans, The Republic of Srpska Report

Author

Kovacevic, Pedja, primary, Topolovac, Sandra, additional, Dragic, Sasa, additional, Jandric, Milka, additional, Momcicevic, Danica, additional, Zlojutro, Biljana, additional, Kovacevic, Tijana, additional, Loncar-Stojiljkovic, Dragana, additional, Djajic, Vlado, additional, Skrbic, Ranko, additional, and Ećim-Zlojutro, Vesna, additional

Published
2022
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10. Dynamic changes in coagulation, hematological and biochemical parameters as predictors of mortality in critically ill COVID–19 patients: A prospective observational study

Author

Zlojutro, Biljana, primary, Jandric, Milka, additional, Momcicevic, Danica, additional, Dragic, Sasa, additional, Kovacevic, Tijana, additional, Djajic, Vlado, additional, Stojiljkovic, Milos, additional, Skrbic, Ranko, additional, Djuric, Dragan, additional, and Kovacevic, Pedja, additional

Published
2022
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11. Dynamic changes in coagulation, hematological and biochemical parameters as predictors of mortality in critically ill COVID–19 patients:a prospective observational study

Author

Zlojutro, Biljana, primary, Jandric, Milka, additional, Momcicević, Danica, additional, Dragic, Sasa, additional, Kovacevic, Tijana, additional, Djajic, Vlado, additional, Stojiljkovic, Milos P., additional, Skrbic, Ranko, additional, Djuric, Dragan M., additional, and Kovacevic, Pedja, additional

Published
2022
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13. Dynamic changes in coagulation, hematological and biochemical parameters as predictors of mortality in critically ill COVID–19 patients: A prospective observational study.

Author

Zlojutro, Biljana, Jandric, Milka, Momcicevic, Danica, Dragic, Sasa, Kovacevic, Tijana, Djajic, Vlado, Stojiljkovic, Milos P., Skrbic, Ranko, Djuric, Dragan M., and Kovacevic, Pedja

Subjects
COVID-19, CRITICALLY ill, ADULT respiratory distress syndrome, BLOOD coagulation, LONGITUDINAL method
Abstract

INTRODUCTION: This study was created to analyze dynamic alterations in coagulation, hematological and biochemical parameters and their association with mortality of COVID-19 patients. To identify the most sensitive biomarkers as predictors of mortality more research is required. METHODS: The present study was a prospective, one-year-long observational study conducted on all critically ill, COVID–19 patients with respiratory failure. The following data were collected: demographic and clinical characteristics of the study population, comorbidities, coagulation, biochemical and hematological parameters. The primary outcome was the proportion of patients who died. RESULTS: 91 patients with median age 60 (50–67), 76.9% male, met the acute respiratory distress syndrome criteria. It was tested whether dynamic change (delta-Δ) of parameters that were found to be predictors of mortality is independently associated with poor outcome. Adjusted (multivariate) analysis was used, where tested parameters were corrected for basic and clinical patients characteristics. The only inflammatory parameter which dynamic change had statistically significant odds ratio was ΔCRP (p < 0.005), while among coagulation parameters statistically significant OR was found for Δ fibrinogen (p < 0.005) in predicting mortality. CONCLUSION: Monitoring of coagulation, hematological and biochemical parameters abnormalities and their dynamical changes can potentially improve management and predict mortality in critically ill COVID –19 patients. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Multiple organ dysfunction caused by a foreign body in the esophagus

Author

Dragic,Sasa, Kovacevic,Pedja, Momcicevic,Danica, Cavka,Jovana, Kovacevic,Tijana, Aleksic,Aleksandra, Jandric,Milka, Zljutro,Biljana, and Djajić,Vlado

Subjects
Corpos estranhos, Mediastinite, Foreign bodies, Mediastinitis, Insuficiência de múltiplos órgãos, Multiple organ failure
Abstract

RESUMO Apresentamos o caso de uma paciente de 71 anos de idade admitida à unidade de terapia intensiva clínica em condição de falência de múltiplos órgãos. Após o quarto dia, com aplicação de todas as modalidades de suporte à vida (estímulo com vasopressores, ventilação mecânica, terapia com diálise contínua, terapia com antibióticos de amplo espectro e outras medidas de suporte), dados inespecíficos fornecidos por acompanhante revelaram que a paciente vinha apresentando dificuldade persistente para deglutir líquidos e alimentos sólidos por alguns dias antes da admissão ao hospital. Após a realização de procedimentos adicionais de diagnóstico radiológico e endoscópico, detectou-se a presença de um corpo estranho no esôfago: um fragmento de fio de aço com cerca de 6 cm de comprimento e dobrado ao meio, que havia penetrado a parede do esôfago e se projetava ao nível da sétima vértebra cervical. Conseguimos remover o corpo estranho por via endoscópica sem maiores complicações e, a seguir, estabilizar nossa paciente, com utilização de medidas terapêuticas adicionais, conforme necessário. ABSTRACT We present the case of a 71-year-old patient who was admitted to the medical intensive care unit in a state of multiple organ dysfunction. After the fourth day of applying all needed life-saving measures (vasopressor stimulation, mechanical ventilation, continuous dialysis treatment, broad spectrum antibiotic therapy, and other supportive measures), nonspecific heteroanamnestic data revealed that the patient had been having a persistent difficulty in swallowing liquids and food for a few days prior to hospital admission. After performing additional radiological and endoscopic diagnostic procedures, a foreign body was detected; a steel wire that had a length of approximately 6cm and was bent in a half had penetrated the esophagus and was projected into the seventh neckline. We managed to evacuate the foreign body endoscopically without further complications, and we stabilized our patient using additional therapeutic measures as needed.

Published
2020

21. Characteristics and Outcomes of Critically ill Patients with Influenza A (H1N1) in the Western Balkans during the 2019 Post-Pandemic Season

Author

Kovacevic, Pedja, primary, Matijasevic, Jovan, additional, Dragic, Sasa, additional, Zlojutro, Biljana, additional, Gavrilovic, Srdjan, additional, Jandric, Milka, additional, Andrijevic, Ana, additional, Kovacevic, Tijana, additional, Carapic, Vladimir, additional, Travar, Maja, additional, Preradovic, Ljubisa, additional, and Momcicevic, Danica, additional

Published
2020
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27. Impact of risk factors on serum levels of vasoactive substances in patients with peripheral arterial occlusive disease at different Fontaine's stages.

Author

Dragic, Sasa, Momcicevic, Danica, Zlojutro, Biljana, Jandric, Milka, Kovacevic, Tijana, Djajic, Vlado, Gajic, Aleksandar, Talic, Goran, and Kovacevic, Pedja

Subjects
*PERIPHERAL vascular diseases, *ARTERIAL occlusions, *BODY mass index, *SERUM, *STATISTICAL significance
Abstract

Introduction: There is a bulk of literature data on the physiological roles of nitric oxide (NO) and endothelin-1 (ET-1), but many facts remain unknown, especially in certain diseases such as peripheral arterial disease. Material and methods: This is an observational cross-sectional study. The subjects were patients diagnosed with PAD. Serum levels of NO and ET-1 were determined for all patients, and statistical data processing was performed according to the set goals. Results: The study included 64 patients with mean age 60.2 ± 12.7 years, mostly in stage II PAD according to Fontain (46.9%). Statistical analysis failed to determine a significant difference in serum NO or ET-1 values with respect to disease stage, sex, and body mass index (BMI). Certain oscillations were found in the mean values of NO related to smoking and diabetes but without statistical significance. There were also oscillations in the values of ET-1, with higher levels found in women, smokers and non-diabetics in whom this difference reached statistical significance (p = 0.041). Conclusion: Serum levels of NO and ET-1 in this study show some causal relationship with certain risk factors for PAD such as diabetes and smoking, but additional research is needed to fully understand their effects and interactions. [ABSTRACT FROM AUTHOR]

Published
2020
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30. Do dynamic changes in haematological and biochemical parameters predict mortality in critically ill COVID-19 patients?

Author

Jandric, Milka, Zlojutro, Biljana, Momcicevic, Danica, Dragic, Sasa, Kovacevic, Tijana, Djajic, Vlado, Stojiljkovic, Milos P., Loncar-Stojiljkovic, Dragana, Skrbic, Ranko, Djuric, Dragan M., and Kovacevic, Pedja

Subjects
*COVID-19, *NEUTROPHIL lymphocyte ratio, *CRITICALLY ill, *LACTATE dehydrogenase, *ARTIFICIAL respiration
Abstract

Critically ill COVID-19 patients are usually subjected to clinical, laboratory, and radiological diagnostic procedures resulting in numerous findings. Utilizing these findings as indicators for disease progression or outcome prediction is particularly intriguing. Exploring the significance of dynamic changes in haematological and biochemical parameters in predicting the mortality of critically ill COVID-19 patients. The present study was a prospective and observational study involving mechanically ventilated 75 critically ill adult COVID-19 patients with hypoxemic respiratory failure. The collected data included baseline patient characteristics, treatment options, outcome, and laboratory findings at admission and 7 days after. The dynamics of the obtained findings were compared between survivors and non-survivors. The 28-day survival rate was 61.3%. In the group of non-survivors significant dynamic changes were found for C-reactive protein (p= 0.001), interleukin-6 (p< 0.001), lymphocyte (p= 0.003), neutrophil-lymphocyte ratio (p= 0.003), platelets (p< 0.001), haemoglobin (p< 0.001), iron (p= 0.012), and total iron-binding capacity (p< 0.001). Statistically significant changes over time were found for ferritin (p= 0.010), D-dimer (p< 0.001), hs-troponin T (p< 0.002), lactate dehydrogenase (p= 0.001), glucose (p= 0.023), unsaturated iron-binding capacity (p= 0.008), and vitamin D (p< 0.001). The dynamic changes in inflammatory, haematological and biochemical parameters can predict disease severity, and outcome. [ABSTRACT FROM AUTHOR]

Published
2024
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