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1. Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling

Author

Rashid, Muhammad Irfanur, Ito, Takuji, Miya, Fuyuki, Shimojo, Daisuke, Arimoto, Kanae, Onodera, Kazunari, Okada, Rina, Nagashima, Takunori, Yamamoto, Kazuki, Khatun, Zohora, Shimul, Rayhanul Islam, Niwa, Jun-ichi, Katsuno, Masahisa, Sobue, Gen, Okano, Hideyuki, Sakurai, Hidetoshi, Shimizu, Kazunori, Doyu, Manabu, and Okada, Yohei

Published
2023
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3. Phase 3B study evaluating superiority of daily dosing vs approved on/off oral edaravone dosing over 48 weeks in patients with amyotrophic lateral sclerosis (MT-1186-A02)

Author

Salah, Alejandro, primary, Desilva, Shari, additional, Zinman, Lorne, additional, Chum, Marvin, additional, Chio, Adriano, additional, Ludolph, Albert C., additional, Sobue, Gen, additional, Doyu, Manabu, additional, Selness, Daniel, additional, Todorovic, Vesna, additional, Hirai, Manabu, additional, Wamil, Art, additional, and Apple, Stephen, additional

Published
2023
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4. Phase 3B extension study evaluating superiority of daily vs approved on/off oral edaravone dosing in patients with amyotrophic lateral sclerosis

Author

Rothstein, Jeffrey, primary, Desilva, Shari, additional, Zinman, Lorne, additional, Chum, Marvin, additional, Chio, Adriano, additional, Ludolph, Albert C., additional, Sobue, Gen, additional, Doyu, Manabu, additional, Selness, Daniel, additional, Todorovic, Vesna, additional, Hirai, Manabu, additional, Fumihiro, Takahashi, additional, Wamil, Art, additional, Salah, Alejandro, additional, and Apple, Stephen, additional

Published
2023
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5. The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)

Author

Takigami, Masayoshi, Kamiyama, Kenji, Houkin, Kiyohiro, Nishi, Shougo, Yoshimoto, Tetsuyuki, Kaneko, Sadao, Oka, Koji, Ooyama, Hiroshi, Kamada, Kyousuke, Makino, Kenichi, Tokumitsu, Naoki, Sako, Kazuhiro, Suzuki, Susumu, Suzuki, Nozomi, Izumi, Naoto, Nitta, Kazumi, Ootaki, Masahumi, Isobe, Masanori, Nishiya, Mikio, Yamazaki, Takaaki, Mabuchi, Syouji, Ogasawara, Kuniaki, Kubo, Naohiko, Shimizu, Yukihiko, Saito, Keiichi, Yamanome, Tatumi, Yoshino, Atsuo, Fujitsuka, Mitsuyuki, Takami, Masaaki, Ohtaka, Hirotoshi, Hirano, Teruyuki, Shiokawa, Yosiaki, Okada, Takaharu, Suzuki, Ichiro, Kohno, Michihiro, Haraoka, Jou, Arai, Yoshinori, Kawamura, Noriyoshi, Isoshima, Akira, Yasue, Masaharu, Takayoshi Kobayashi, Mitsuhiko Hokari, Kawai, Kensuke, Maehara, Taketoshi, Arai, Hajime, Noguchi, Makoto, Hoshino, Haruhiko, Hiyama, Hirofumi, Yoshida, Kensaku, Utsugi, Osamu, Takeda, Yasuaki, Tamaki, Kouichi, Karasudani, Hirohide, Urabe, Takao, Kobayashi, Shiro, Nakamura, Michio, Koguchi, Yorio, Ono, Junichi, Suda, Sumio, Hadeishi, Hiromu, Fukutake, Toshio, Wakui, Kenji, Tanno, Hirokazu, Ishige, Naoki, Ohasi, Takashi, Sakai, Hideki, Nishimura, Yasuaki, Watanabe, Takayuki, Matsumoto, Takashi, Koketsu, Naoki, Hirose, Yuichi, Doyu, Manabu, Hasegawa, Toshinori, Kuwayama, Naoto, Terao, Shinichi, Mizutani, Nobuhiko, Suzaki, Noriyuki, Okuda, Satoshi, Yasui, Keizo, Seki, Yukio, Hasegawa, Yasuhiro, Ikeda, Akira, Takeuchi, Youtarou, Ohara, Sigeki, Araki, Yoshio, Wakabayashi, Toshihiko, Tanaka, Hisashi, Yoshimoto, Junpei, Sugiura, Makoto, Koichiro, Ogura, Kobayashi, Nozomu, Yamada, Tomonori, Kato, Amami, Toshiho, Ohtsuki, Wakayama, Akatsuki, Takahashi, Jun, Kataoka, Hiroharu, Yoshimine, Toshiki, Nakajima, Yoshikazu, Gi, Hidehuku, Uranishi, Ryunosuke, Nakamura, Yusaku, Yamanaka, Kazunori, Ohmori, Kazumi, Matsumoto, Hiroyuki, Oiwa, Yoshitugu, Uemura, Yosihiko, Fujiwara, Hiroaki, Iwai, Yoshiyasu, Morikawa, Masashi, Tane, Kazuyuki, Hashikawa, Kazuo, Fujinaka, Toshiyuki, Yoneda, Shunichi, Yamashita, Kohsuke, Kitano, Masahiko, Tominaga, Shinsuke, Nakamura, Kazuhito, Kono, Katsuhiko, Ohata, Kenji, Taniguchi, Hirokatsu, Hazama, Takanori, Kuroiwa, Toshihiko, Tamura, Yoji, Maeno, Kazusige, Arai, Motohiro, Iwase, Masaaki, Hashimoto, Kenji, Yamada, Keisuke, Turuno, Takashi, Ichinose, Tsutomu, Kurokawa, Shinichiro, Matsuyama, Takeshi, Fujita, Toshiaki, Yuguchi, Takamichi, Teramoto, Yoshihumi, Kakita, Hiroto, Matsuo, Takayuki, Izumo, Tsuyoshi, Ryu, Nobutoshi, Naoki Kitagawa, Wataru Haraguchi, Kaminogo, Makio, Sakamoto, Seisaburo, Tokunaga, Yosiharu, Urasaki, Ei-Ichirou, Kuratsu, Junichi, Takada, Akira, Terasaki, Tadashi, Hisami Oosima, Isao Fuwa, Yamashiro, Shigeo, Hiromasa Tsuiki, Makoto Yoshikawa, Koga, Kazunari, Egami, Hiroshi, Kawamura, Tadao, Mitsuo, Kunihiko, Masaki Morisige, Takamitu Hikawa, Takeda, Yuu, Yamaguchi, Yutaka, Shunro Uchinokura, Shiro Miyata, Goya, Tomokazu, Takeshima, Hideo, Yatsushiro, Kazutaka, Ohta, Hajime, Nagadou, Tatsui, Hirahara, Kazuho, Obara, Souichi, Seto, Hiroshi, Moroki, Koiti, Arita, Kazunori, Ishiuchi, Shogo, Uchihara, Toshimitsu, Mekaru, Susumu, Nagamine, Tomoaki, Jin Momoji, Naoki Tomiyama, Atusi Kimoto, Kouzi Idomari, Kadekaru, Tsutomu, Syamoto, Hirosi, Sasaki, Osamu, Minagawa, Makoto, Takahashi, Hideaki, Hiroyuki Arai, Kiyoshi Onda, Takeuchi, Shigekazu, Abe, Hiroshi, Fukuda, Osamu, Kouno, Mitsuo, Tamura, Tetsuro, Michiya Kubo, Yukio Horie, Hondo, Hiroaki, Takada, Hisashi, Masuoka, Toru, Shirasaki, Naoki, Nitta, Hisashi, Yasuo Katsuki, Makoto Kimura, Hisato Minamide, Yutaka Hayashi, Munemoto, Shigeru, Ikeda, Kiyonobu, Yutaka Hayashi, Mitsutoshi Nakada, Sato, Syuji, Hatano, Taketo, Yamamura, Osamu, Kabuto, Masanori, Jyunya Hayashi, Takahiro Sakuma, Kinouchi, Hiroyuki, Koizumi, Hidehito, Imae, Syougo, Fujita, Manabu, Suga, Masakazu, Kanehisa Kohno, Shinji Iwata, Zenke, Kiichiro, Fujisawa, Mutsuo, Mizobuchi, Hikaru, Hayashi, Satoru, Morimoto, Masanori, Ueba, Tetsuya, Nishimura, Hiroyuki, Ikawa, Naoki, Matsumoto, Yuzo, Kannuki, Seiji, Kagawa, Masahiro, Hayashi, Naoki, Atsushi Shindo, Takashi Tamiya, Yoshino, Kimihiro, Masaoka, Tetsuya, Nakahara, Ichiro, Satoshi Suzuki, Akira Nakamizo, Okamoto, Yuji, Takahashi, Haruki, Iihara, Koji, Hirakawa, Katsuyuki, Nagata, Shinji, Ookura, Akio, Yoshiro Kaneko, Hidenori Yoshida, Nakane, Hiroshi, Inoue, Isao, Hitotsumatsu, Tsutomu, Kouichi Kuramoto, Terukazu Kuramoto, Hiromichi Ooishi, Yoshihisa Matumoto, Masani Nonaka, Tooru Inoue, Morioka, Motohiro, Shuji Sakata, Hiroshi Sugimori, Takashima, Hiroshi, Ishihara, Shin-Ichiro, Suzuyama, Kenji, Miyazono, Masayuki, Itaro Hattori, Masafumi Morimoto, Ozaki, Satoshi, Hirota, Nobuo, Yasuhiko Mochimatsu, Yasunori Takemoto, Takagi, Makoto, Kenji Nakayama, Isao Yamamoto, Hiroshi Tanaka, Yoshinori Uchida, Sakata, Katsumi, Nobutaka, Kawahara, Nomura, Motohiro, Ozawa, Hitoshi, Tsumura, Kotaro, Michiyuki Maruyama, Makoto Inaba, Mori, Tatsuro, Mori, Takahisa, Sugitani, Masato, Tanaka, Yuichiro, Yamada, Masaru, Matsumae, Mitsunori, Onitsuka, Keiichirou, Tatsuya Takahashi, Kosuke Miyahara, Endou, Sumio, Takahashi, Hidekazu, Kaidu, Hiroyuki, Chikashi Maruki, Akira Tsunoda, Fujimaki, Takamitsu, Ooigawa, Hidetoshi, Masatsugu Uchida, Masahiko Tanaka, Kouiti Katoh, Hiroshi Wanihuti, Hyodo, Akio, Asakura, Ken, Nakajima, Shigeyoshi, Kanzawa, Takao, Kurihara, Hideyuki, Ohmori, Sigehiro, Hiroshi Kusunoki, Mitsugi Yoshinao, Magarisawa, Satoshi, Okabe, Shinichi, Kujiraoka, Yuuji, Tsuruoka, Shin, Takeshita, Mikihiko, Akira Matsumura, Tetsuya Yamamoto, Uemura, Kazuya, Tabata, Hitoshi, Sonobe, Makoto, Ryoji Yoshida, Masashi Nakatsukasa, Shimoeda, Norifumi, Kunimine, Hideo, Ishihara, Masayuki, Murai, Nozomu, Murakami, Nobukuni, Kidooka, Minoru, Iwamoto, Yoshihiro, Tenjin, Hiroshi, Masahiko Takamasu, Kouji Shiga, Mori, Nobuhito, Kose, Shigeru, Kohmura, Eiji, Matsumoto, Keigo, Sakaki, Takayuki, Miyake, Hiroji, Mabuchi, Eiichiro, Yokota, Masayuki, Yosihiro Kuga, Hideyuki Ohnishi, Kimura, Mitsuru, Masaaki Saiki, Osamu Narumi, Nakajima, Norio, Asahi, Minoru, Koyama, Junji, Noda, Shinya, Iida, Junichi, Fujita, Toyohisa, Nakase, Hiroyuki, Toru Hoshida, Hidehiro Hirabayashi, Fujimoto, Takayoshi, Nakao, Naoyuki, Tanaka, Yoshiyuki, Ozaki, Fuminori, Nakamura, Yoshinari, Miki, Kazuhito, Watanabe, Takashi, Hasegawa, Seiko, Konno, Hiromu, Takemura, Atsuhito, Okubo, Atsuya, Saito, Hitoshi, Taizen Nakase, Tatsuya Ishikawa, Toshio Sasajima, Hiroaki Shimizu, Sasou, Masayuki, Watanabe, Yoichi, Kiyoshi Saito, Taku Sato, Masahiro Satoh, Satoshi Taira, Koizumi, Takayuki, Shoji Mashiyama, Yasuhiro Suzuki, Oikawa, Tomoyoshi, Sonoda, Yukihiko, Shinjiro Saito, Rei Kondo, Shinoda, Atsuo, Kamatsuka, Eiichiro, So, Keiten, Kinjo, Toshihiko, Kennji Itou, Tooru Sasaki, Hiroaki Shimizu, Hidenori Endo, Karibe, Hirosi, Takahashi, Kou, Nakajima, Masayuki, Watanabe, Kazuyoshi, Takayama, Motohiro, Komuro, Taro, Fumio Suzuki, Hisao Hirai, Suzuki, Hidenori, Murata, Hiroto, Miya, Fumitaka, Kanamaru, Kenji, Tamura, Akira, Harada, Kiyoshi, Fukazawa, Seiji, Takehara, Seiya, Watanabe, Yoshihiko, Nakayama, Teiji, Hiroshi Nagura, Haruhiko Sato, Chiharu Tanoi, Shinji Amano, Kuroda, Katsuhiro, Morooka, Satoru, Masashi Kitagawa, Takafumi Wataya, Koide, Kazuo, Tanigawara, Tetsuya, Iwama, Toru, Ito, Junki, Noda, Shinji, Kouno, Kazuyuki, Kitazawa, Kazuo, Toshiki Takemae, Yoshikazu Kusano, Hokama, Masanobu, Yoshihisa Nishiyama, Hiroki Sato, Seguchi, Tatsuya, Yoshihiko Inui, Sumio Kobayashi, Oohigashi, Youji, Muraoka, Shinsuke, Miyatake, Masaki, Nakagawa Shinichi, Kensuke Hayashida, Inoue, Atsushi, Sakai, Keiichi, Yamaguchi, Shuhei, Fusao Ikawa, Tatsuya Mizoue, Hideki Irie, Gen Ishida, Kagawa, Takato, Namba, Yoichiro, Nakashima, Hiroyuki, Koji Abe, Isao Date, Uno, Masaaki, Sen Yamagata, Masaki Chin, Soitiro Takao, Hidemiti Sasayama, Kouji Muneda, Hideyuki Yoshida, Watanebe, Akira, Katou, Syouichi, Hamada, Yasuhiro, Suzuki, Michiyasu, Nishizaki, Takafumi, Yamashita, Katsuhiro, Ryuji Nakamura, Takaharu Nakamura, Wakabayashi, Shinichi, Okazaki, Takahito, Kurisu, Kaoru, Matsumoto, Masayasu, Katsuzo Kiya, Atsushi Tominaga, Syuichi Oki, Masaaki Shibukawa, Nakahara, Toshinori, Okita, Shinji, Torii, Tuyosi, Kenjirou Fujiwara, Minoru Nakagawa, Syuuhei Nishimura, Takashi Matsuoka, Naoyuki Isobe, Osamu Hamasaki, Shinji Nagahiro, Junichiro Satomi, Agawa, Masahito, Oka, Hirofumi, Yoshimura, Kunikazu, Kato, Tsutomu, Satoshi Minoshima, Nobuaki Kobayasi, Mikuni, Nobuhiro, Tanikawa, Rokuya, Sasaki, Jyunkou, Otawara, Yasunari, Tominaga, Teiji, Sasaki, Tatsuya, Takemura, Sunao, Kawakami, Masahisa, Ihara, Satoshi, Shibata, Yasushi, Saegusa, Takashi, Iuchi, Toshihiko, Ito, Chiaki, Okuda, Osamu, Yoshida, Kazunari, Masateru Katayama, Sadao Suga, Akihiro, Oikawa, Miura, Naohisa, Ota, Takahiro, Kumabe, Toshihiro, Suzuki, Sachio, Kumagai, Takashi, Nishimaki, Keiichi, Hongo, Kazuhiro, Shigeta, Hiroaki, Hattori, Kazuyoshi, Uozumi, Yoichi, Nakahara, Norimoto, Hashimoto, Nobukazu, Shu Imai, Shinichi Shirakami, Okumura, Yoshinari, Kazuhiro Yokoyama, Ryo Tamaki, Miyamoto, Susumu, Yamamoto, Kazuo, Ichioka, Tsugumichi, Inoue, Tsuyoshi, Kinoshita, Manabu, Saitoh, Minoru, Aihara, Hideo, Miyake, Hajimu, Tukasa Nishiura, Kotaro Ogihara, Nishino, Shigeki, Miyoshi, Yasuyuki, Arisawa, Tadashi, Shoji Tsuchimoto, Shigeru Daido, Kinoshita, Kimihisa, Keisuke Migita, Kiyoshi Yuki, Akatsuka, Keiichi, Fujisawa, Hirosuke, Shono, Tadahisa, Tsugu, Hitoshi, Hayashi, Shuji, Toshio Matsushima, Tatsuya Abe, Nakashima, Susumu, Tuji, Takehisa, Kaga, Akihiko, Kanemaru, Reizou, Takasaki, Koji, Imamura, Junichi, Noha, Masahiro, Watanabe, Saburo, Sakai, Nobuyuki, Hiroaki Minami, Yasuhisa Yoshida, Okumura, Tomoyoshi, Nishimura, Shinjitsu, Numazawa, Shinichi, Masanori Tsutsumi, Kiyoshi Kazekawa, Fukuyama, Kouzou, Fujimoto, Yasuhiro, Yamagami, Keitaro, Kurogi, Ryota, Kurogi, Ai, Nishimura, Kunihiro, Onozuka, Daisuke, Ren, Nice, Kada, Akiko, Nishimura, Ataru, Arimura, Koichi, Ido, Keisuke, Mizoguchi, Masahiro, Sakamoto, Tetsuya, Kayama, Takamasa, and Hagihara, Akihito

Published
2019
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7. Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs

Author

Onodera, Kazunari, Shimojo, Daisuke, Ishihara, Yasuharu, Yano, Masato, Miya, Fuyuki, Banno, Haruhiko, Kuzumaki, Naoko, Ito, Takuji, Okada, Rina, de Araújo Herculano, Bruno, Ohyama, Manabu, Yoshida, Mari, Tsunoda, Tatsuhiko, Katsuno, Masahisa, Doyu, Manabu, Sobue, Gen, Okano, Hideyuki, and Okada, Yohei

Published
2020
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9. Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients

Author

Nakamura, Ryoichi, primary, Tohnai, Genki, additional, Nakatochi, Masahiro, additional, Atsuta, Naoki, additional, Watanabe, Hirohisa, additional, Ito, Daisuke, additional, Katsuno, Masahisa, additional, Hirakawa, Akihiro, additional, Izumi, Yuishin, additional, Morita, Mitsuya, additional, Hirayama, Takehisa, additional, Kano, Osamu, additional, Kanai, Kazuaki, additional, Hattori, Nobutaka, additional, Taniguchi, Akira, additional, Suzuki, Naoki, additional, Aoki, Masashi, additional, Iwata, Ikuko, additional, Yabe, Ichiro, additional, Shibuya, Kazumoto, additional, Kuwabara, Satoshi, additional, Oda, Masaya, additional, Hashimoto, Rina, additional, Aiba, Ikuko, additional, Ishihara, Tomohiko, additional, Onodera, Osamu, additional, Yamashita, Toru, additional, Abe, Koji, additional, Mizoguchi, Kouichi, additional, Shimizu, Toshio, additional, Ikeda, Yoshio, additional, Yokota, Takanori, additional, Hasegawa, Kazuko, additional, Tanaka, Fumiaki, additional, Nakashima, Kenji, additional, Kaji, Ryuji, additional, Niwa, Jun-ichi, additional, Doyu, Manabu, additional, Terao, Chikashi, additional, Ikegawa, Shiro, additional, Fujimori, Koki, additional, Nakamura, Shiho, additional, Ozawa, Fumiko, additional, Morimoto, Satoru, additional, Onodera, Kazunari, additional, Ito, Takuji, additional, Okada, Yohei, additional, Okano, Hideyuki, additional, and Sobue, Gen, additional

Published
2023
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10. An Exploratory Trial of EPI-589 in Amyotrophic Lateral Sclerosis (EPIC-ALS): Protocol for a Multicenter, Open-Labeled, 24-Week, Single-Group Study

Author

Haji, Shotaro, primary, Fujita, Koji, additional, Oki, Ryosuke, additional, Osaki, Yusuke, additional, Miyamoto, Ryosuke, additional, Morino, Hiroyuki, additional, Nagano, Seiichi, additional, Atsuta, Naoki, additional, Kanazawa, Yuki, additional, Matsumoto, Yuki, additional, Arisawa, Atsuko, additional, Kawai, Hisashi, additional, Sato, Yasutaka, additional, Sakaguchi, Satoshi, additional, Yagi, Kenta, additional, Hamatani, Tatsuto, additional, Kagimura, Tatsuo, additional, Yanagawa, Hiroaki, additional, Mochizuki, Hideki, additional, Doyu, Manabu, additional, Sobue, Gen, additional, Harada, Masafumi, additional, and Izumi, Yuishin, additional

Published
2023
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11. The protocol of EPI-589 early Phase 2 Investigator-initiated Clinical trial for ALS (EPIC-ALS): A multi-center, open-labeled, 24-week, single-group, exploratory trial to evaluate the efficacy, safety, and biomarker effects of EPI-589 in amyotrophic lateral sclerosis (Preprint)

Author

Haji, Shotaro, primary, Fujita, Koji, additional, Oki, Ryosuke, additional, Osaki, Yusuke, additional, Miyamoto, Ryosuke, additional, Morino, Hiroyuki, additional, Nagano, Seiichi, additional, Atsuta, Naoki, additional, Kanazawa, Yuki, additional, Matsumoto, Yuki, additional, Arisawa, Atsuko, additional, Kawai, Hisashi, additional, Sato, Yasutaka, additional, Sakaguchi, Satoshi, additional, Yagi, Kenta, additional, Hamatani, Tatsuto, additional, Kagimura, Tatsuo, additional, Yanagawa, Hiroaki, additional, Mochizuki, Hideki, additional, Doyu, Manabu, additional, Sobue, Gen, additional, Harada, Masafumi, additional, and Izumi, Yuishin, additional

Published
2022
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17. Simple and efficient differentiation of human iPSCs into contractible skeletal muscles for muscular disease modeling

Author

Muhammad Irfanur, Rashid, primary, Ito, Takuji, additional, Shimojo, Daisuke, additional, Arimoto, Kanae, additional, Onodera, Kazunari, additional, Okada, Rina, additional, Nagashima, Takunori, additional, Yamamoto, Kazuki, additional, Khatun, Zohora, additional, Okano, Hideyuki, additional, Sakurai, Hidetoshi, additional, Shimizu, Kazunori, additional, Doyu, Manabu, additional, and Okada, Yohei, additional

Published
2021
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18. Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson’s disease

Author

Taguchi, Soutarou, primary, Koide, Hirofumi, additional, Oiwa, Hiroko, additional, Hayashi, Miku, additional, Ogawa, Kazuhiro, additional, Ito, Chihiro, additional, Nakashima, Koji, additional, Yuasa, Tomoko, additional, Yasumoto, Akihiro, additional, Ando, Hiroaki, additional, Fujikake, Akifumi, additional, Fukuoka, Takaaki, additional, Tokui, Keisuke, additional, Izumi, Masayuki, additional, Tsunoda, Yuka, additional, Kawagashira, Yuichi, additional, Okada, Yohei, additional, Niwa, Jun-ichi, additional, and Doyu, Manabu, additional

Published
2021
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21. Pharmacological induction of heat-shock proteins alleviates polyglutamine-mediated motor neuron disease

Author

Katsuno, Masahisa, Sang, Chen, Adachi, Hiroaki, Minamiyama, Makoto, Waza, Masahiro, Tanaka, Fumiaki, Doyu, Manabu, and Sobue, Gen

Subjects
Androgens -- Research, Atrophy, Muscular -- Research, Muscle diseases -- Research, Science and technology
Abstract

Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease caused by the expansion of a trinucleotide CAG repeat encoding the polyglutamine tract in the first exon of the androgen receptor gene (AR). The pathogenic, polyglutamine-expanded AR protein accumulates in the cell nucleus in a ligand-dependent manner and inhibits transcription by interfering with transcriptional factors and coactivators. Heat-shock proteins (HSPs) are stress-induced chaperones that facilitate the refolding and, thus, the degradation of abnormal proteins. Geranylgeranylacetone (GGA), a nontoxic antiulcer drug, has been shown to potently induce HSP expression in various tissues, including the central nervous system. In a cell model of SBMA, GGA increased the levels of Hsp70, Hsp90, and Hsp105 and inhibited cell death and the accumulation of pathogenic AR. Oral administration of GGA also up-regulated the expression of HSPs in the central nervous system of SBMA-transgenic mice and suppressed nuclear accumulation of the pathogenic AR protein, resulting in amelioration of polyglutamine-dependent neuromuscular phenotypes. These observations suggest that, although a high dose appears to be needed for clinical effects, oral GGA administration is a safe and promising therapeutic candidate for polyglutamine-mediated neurodegenerative diseases, including SBMA. spinal and bulbar muscular atrophy | geranylgeranylacetone | androgen receptor | heat-shock factor-1

Published
2005

22. 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration

Author

Waza, Masahiro, Adachi, Hiroaki, Katsuno, Masahisa, Minamiyama, Makoto, Sang, Chen, Tanaka, Fumiaki, Inukai, Akira, Doyu, Manabu, and Sobue, Gen

Abstract

Heat-shock protein 90 (Hsp90) functions as part of a multichaperone complex that folds, activates and assembles its client proteins. Androgen receptor (AR), a pathogenic gene product in spinal and bulbar muscular atrophy (SBMA), is one of the Hsp90 client proteins. We examined the therapeutic effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG), a potent Hsp90 inhibitor, and its ability to degrade polyglutamine-expanded mutant AR. Administration of 17-AAG markedly ameliorated motor impairments in the SBMA transgenic mouse model without detectable toxicity, by reducing amounts of monomeric and aggregated mutant AR. The mutant AR showed a higher affinity for Hsp90-p23 and preferentially formed an Hsp90 chaperone complex as compared to wild-type AR; mutant AR was preferentially degraded in the presence of 17-AAG in both cells and transgenic mice as compared to wild-type AR. 17-AAG also mildly induced Hsp70 and Hsp40. 17-AAG would thus provide a new therapeutic approach to SBMA and probably to other related neurodegenerative diseases., Author(s): Masahiro Waza [1, 2]; Hiroaki Adachi [1, 2]; Masahisa Katsuno [1]; Makoto Minamiyama [1]; Chen Sang [1]; Fumiaki Tanaka [1]; Akira Inukai [1]; Manabu Doyu [1]; Gen Sobue (corresponding [...]

Published
2005
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24. Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy

Author

Katsuno, Masahisa, Adachi, Hiroaki, Doyu, Manabu, Minamiyama, Makoto, Sang, Chen, Kobayashi, Yasushi, Inukai, Akira, and Sobue, Gen

Abstract

Spinal and bulbar muscular atrophy (SBMA) is an adult-onset motor neuron disease that affects males. It is caused by the expansion of a polyglutamine (polyQ) tract in androgen receptors. Female carriers are usually asymptomatic. No specific treatment has been established. Our transgenic mouse model carrying a full-length human androgen receptor with expanded polyQ has considerable gender-related motor impairment. This phenotype was abrogated by castration, which prevented nuclear translocation of mutant androgen receptors. We examined the effect of androgen-blockade drugs on our mouse model. Leuprorelin, a lutenizing hormone-releasing hormone (LHRH) agonist that reduces testosterone release from the testis, rescued motor dysfunction and nuclear accumulation of mutant androgen receptors in male transgenic mice. Moreover, leuprorelin treatment reversed the behavioral and histopathological phenotypes that were once caused by transient increases in serum testosterone. Flutamide, an androgen antagonist promoting nuclear translocation of androgen receptors, yielded no therapeutic effect. Leuprorelin thus seems to be a promising candidate for the treatment of SBMA., Author(s): Masahisa Katsuno [1]; Hiroaki Adachi [1]; Manabu Doyu [1]; Makoto Minamiyama [1]; Chen Sang [1]; Yasushi Kobayashi [1]; Akira Inukai [1]; Gen Sobue (corresponding author) [1] SBMA, also known [...]

Published
2003
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30. Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs

Author

Onodera, Kazunari, primary, Shimojo, Daisuke, additional, Ishihara, Yasuharu, additional, Yano, Masato, additional, Miya, Fuyuki, additional, Banno, Haruhiko, additional, Kuzumaki, Naoko, additional, Ito, Takuji, additional, Okada, Rina, additional, Herculano, Bruno de Araujo, additional, Ohyama, Manabu, additional, Yoshida, Mari, additional, Tsunoda, Tatsuhiko, additional, Katsuno, Masahisa, additional, Doyu, Manabu, additional, Sobue, Gen, additional, Okano, Hideyuki, additional, and Okada, Yohei, additional

Published
2020
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45. The Influence of Age on the Outcomes of Traumatic Brain Injury: Findings from a Japanese Nationwide Survey (J-ASPECT Study-Traumatic Brain Injury)

Author

Yamagami, Keitaro, primary, Kurogi, Ryota, additional, Kurogi, Ai, additional, Nishimura, Kunihiro, additional, Onozuka, Daisuke, additional, Ren, Nice, additional, Kada, Akiko, additional, Nishimura, Ataru, additional, Arimura, Koichi, additional, Ido, Keisuke, additional, Mizoguchi, Masahiro, additional, Sakamoto, Tetsuya, additional, Kayama, Takamasa, additional, Suzuki, Michiyasu, additional, Arai, Hajime, additional, Hagihara, Akihito, additional, Iihara, Koji, additional, Takigami, Masayoshi, additional, Kamiyama, Kenji, additional, Houkin, Kiyohiro, additional, Nishi, Shougo, additional, Yoshimoto, Tetsuyuki, additional, Kaneko, Sadao, additional, Oka, Koji, additional, Ooyama, Hiroshi, additional, Kamada, Kyousuke, additional, Makino, Kenichi, additional, Tokumitsu, Naoki, additional, Sako, Kazuhiro, additional, Suzuki, Susumu, additional, Suzuki, Nozomi, additional, Izumi, Naoto, additional, Nitta, Kazumi, additional, Ootaki, Masahumi, additional, Isobe, Masanori, additional, Nishiya, Mikio, additional, Yamazaki, Takaaki, additional, Mabuchi, Syouji, additional, Ogasawara, Kuniaki, additional, Kubo, Naohiko, additional, Shimizu, Yukihiko, additional, Saito, Keiichi, additional, Yamanome, Tatumi, additional, Yoshino, Atsuo, additional, Fujitsuka, Mitsuyuki, additional, Takami, Masaaki, additional, Ohtaka, Hirotoshi, additional, Hirano, Teruyuki, additional, Shiokawa, Yosiaki, additional, Okada, Takaharu, additional, Suzuki, Ichiro, additional, Kohno, Michihiro, additional, Haraoka, Jou, additional, Arai, Yoshinori, additional, Kawamura, Noriyoshi, additional, Isoshima, Akira, additional, Yasue, Masaharu, additional, Takayoshi Kobayashi, Mitsuhiko Hokari, additional, Kawai, Kensuke, additional, Maehara, Taketoshi, additional, Noguchi, Makoto, additional, Hoshino, Haruhiko, additional, Hiyama, Hirofumi, additional, Yoshida, Kensaku, additional, Utsugi, Osamu, additional, Takeda, Yasuaki, additional, Tamaki, Kouichi, additional, Karasudani, Hirohide, additional, Urabe, Takao, additional, Kobayashi, Shiro, additional, Nakamura, Michio, additional, Koguchi, Yorio, additional, Ono, Junichi, additional, Suda, Sumio, additional, Hadeishi, Hiromu, additional, Fukutake, Toshio, additional, Wakui, Kenji, additional, Tanno, Hirokazu, additional, Ishige, Naoki, additional, Ohasi, Takashi, additional, Sakai, Hideki, additional, Nishimura, Yasuaki, additional, Watanabe, Takayuki, additional, Matsumoto, Takashi, additional, Koketsu, Naoki, additional, Hirose, Yuichi, additional, Doyu, Manabu, additional, Hasegawa, Toshinori, additional, Kuwayama, Naoto, additional, Terao, Shinichi, additional, Mizutani, Nobuhiko, additional, Suzaki, Noriyuki, additional, Okuda, Satoshi, additional, Yasui, Keizo, additional, Seki, Yukio, additional, Hasegawa, Yasuhiro, additional, Ikeda, Akira, additional, Takeuchi, Youtarou, additional, Ohara, Sigeki, additional, Araki, Yoshio, additional, Wakabayashi, Toshihiko, additional, Tanaka, Hisashi, additional, Yoshimoto, Junpei, additional, Sugiura, Makoto, additional, Koichiro, Ogura, additional, Kobayashi, Nozomu, additional, Yamada, Tomonori, additional, Kato, Amami, additional, Toshiho, Ohtsuki, additional, Wakayama, Akatsuki, additional, Takahashi, Jun, additional, Kataoka, Hiroharu, additional, Yoshimine, Toshiki, additional, Nakajima, Yoshikazu, additional, Gi, Hidehuku, additional, Uranishi, Ryunosuke, additional, Nakamura, Yusaku, additional, Yamanaka, Kazunori, additional, Ohmori, Kazumi, additional, Matsumoto, Hiroyuki, additional, Oiwa, Yoshitugu, additional, Uemura, Yosihiko, additional, Fujiwara, Hiroaki, additional, Iwai, Yoshiyasu, additional, Morikawa, Masashi, additional, Tane, Kazuyuki, additional, Hashikawa, Kazuo, additional, Fujinaka, Toshiyuki, additional, Yoneda, Shunichi, additional, Yamashita, Kohsuke, additional, Kitano, Masahiko, additional, Tominaga, Shinsuke, additional, Nakamura, Kazuhito, additional, Kono, Katsuhiko, additional, Ohata, Kenji, additional, Taniguchi, Hirokatsu, additional, Hazama, Takanori, additional, Kuroiwa, Toshihiko, additional, Tamura, Yoji, additional, Maeno, Kazusige, additional, Arai, Motohiro, additional, Iwase, Masaaki, additional, Hashimoto, Kenji, additional, Yamada, Keisuke, additional, Turuno, Takashi, additional, Ichinose, Tsutomu, additional, Kurokawa, Shinichiro, additional, Matsuyama, Takeshi, additional, Fujita, Toshiaki, additional, Yuguchi, Takamichi, additional, Teramoto, Yoshihumi, additional, Kakita, Hiroto, additional, Matsuo, Takayuki, additional, Izumo, Tsuyoshi, additional, Ryu, Nobutoshi, additional, Naoki Kitagawa, Wataru Haraguchi, additional, Kaminogo, Makio, additional, Sakamoto, Seisaburo, additional, Tokunaga, Yosiharu, additional, Urasaki, Ei-Ichirou, additional, Kuratsu, Junichi, additional, Takada, Akira, additional, Terasaki, Tadashi, additional, Hisami Oosima, Isao Fuwa, additional, Yamashiro, Shigeo, additional, Hiromasa Tsuiki, Makoto Yoshikawa, additional, Koga, Kazunari, additional, Egami, Hiroshi, additional, Kawamura, Tadao, additional, Mitsuo, Kunihiko, additional, Masaki Morisige, Takamitu Hikawa, additional, Takeda, Yuu, additional, Yamaguchi, Yutaka, additional, Shunro Uchinokura, Shiro Miyata, additional, Goya, Tomokazu, additional, Takeshima, Hideo, additional, Yatsushiro, Kazutaka, additional, Ohta, Hajime, additional, Nagadou, Tatsui, additional, Hirahara, Kazuho, additional, Obara, Souichi, additional, Seto, Hiroshi, additional, Moroki, Koiti, additional, Arita, Kazunori, additional, Ishiuchi, Shogo, additional, Uchihara, Toshimitsu, additional, Mekaru, Susumu, additional, Nagamine, Tomoaki, additional, Jin Momoji, Naoki Tomiyama, additional, Atusi Kimoto, Kouzi Idomari, additional, Kadekaru, Tsutomu, additional, Syamoto, Hirosi, additional, Sasaki, Osamu, additional, Minagawa, Makoto, additional, Takahashi, Hideaki, additional, Hiroyuki Arai, Kiyoshi Onda, additional, Takeuchi, Shigekazu, additional, Abe, Hiroshi, additional, Fukuda, Osamu, additional, Kouno, Mitsuo, additional, Tamura, Tetsuro, additional, Michiya Kubo, Yukio Horie, additional, Hondo, Hiroaki, additional, Takada, Hisashi, additional, Masuoka, Toru, additional, Shirasaki, Naoki, additional, Nitta, Hisashi, additional, Yasuo Katsuki, Makoto Kimura, additional, Hisato Minamide, Yutaka Hayashi, additional, Munemoto, Shigeru, additional, Ikeda, Kiyonobu, additional, Yutaka Hayashi, Mitsutoshi Nakada, additional, Sato, Syuji, additional, Hatano, Taketo, additional, Yamamura, Osamu, additional, Kabuto, Masanori, additional, Jyunya Hayashi, Takahiro Sakuma, additional, Kinouchi, Hiroyuki, additional, Koizumi, Hidehito, additional, Imae, Syougo, additional, Fujita, Manabu, additional, Suga, Masakazu, additional, Kanehisa Kohno, Shinji Iwata, additional, Zenke, Kiichiro, additional, Fujisawa, Mutsuo, additional, Mizobuchi, Hikaru, additional, Hayashi, Satoru, additional, Morimoto, Masanori, additional, Ueba, Tetsuya, additional, Nishimura, Hiroyuki, additional, Ikawa, Naoki, additional, Matsumoto, Yuzo, additional, Kannuki, Seiji, additional, Kagawa, Masahiro, additional, Hayashi, Naoki, additional, Atsushi Shindo, Takashi Tamiya, additional, Yoshino, Kimihiro, additional, Masaoka, Tetsuya, additional, Nakahara, Ichiro, additional, Satoshi Suzuki, Akira Nakamizo, additional, Okamoto, Yuji, additional, Takahashi, Haruki, additional, Hirakawa, Katsuyuki, additional, Nagata, Shinji, additional, Ookura, Akio, additional, Yoshiro Kaneko, Hidenori Yoshida, additional, Nakane, Hiroshi, additional, Inoue, Isao, additional, Hitotsumatsu, Tsutomu, additional, Kouichi Kuramoto, Terukazu Kuramoto, additional, Hiromichi Ooishi, Yoshihisa Matumoto, additional, Masani Nonaka, Tooru Inoue, additional, Morioka, Motohiro, additional, Shuji Sakata, Hiroshi Sugimori, additional, Takashima, Hiroshi, additional, Ishihara, Shin-Ichiro, additional, Suzuyama, Kenji, additional, Miyazono, Masayuki, additional, Itaro Hattori, Masafumi Morimoto, additional, Ozaki, Satoshi, additional, Hirota, Nobuo, additional, Yasuhiko Mochimatsu, Yasunori Takemoto, additional, Takagi, Makoto, additional, Kenji Nakayama, Isao Yamamoto, additional, Hiroshi Tanaka, Yoshinori Uchida, additional, Sakata, Katsumi, additional, Nobutaka, Kawahara, additional, Nomura, Motohiro, additional, Ozawa, Hitoshi, additional, Tsumura, Kotaro, additional, Michiyuki Maruyama, Makoto Inaba, additional, Mori, Tatsuro, additional, Mori, Takahisa, additional, Sugitani, Masato, additional, Tanaka, Yuichiro, additional, Yamada, Masaru, additional, Matsumae, Mitsunori, additional, Onitsuka, Keiichirou, additional, Tatsuya Takahashi, Kosuke Miyahara, additional, Endou, Sumio, additional, Takahashi, Hidekazu, additional, Kaidu, Hiroyuki, additional, Chikashi Maruki, Akira Tsunoda, additional, Fujimaki, Takamitsu, additional, Ooigawa, Hidetoshi, additional, Masatsugu Uchida, Masahiko Tanaka, additional, Kouiti Katoh, Hiroshi Wanihuti, additional, Hyodo, Akio, additional, Asakura, Ken, additional, Nakajima, Shigeyoshi, additional, Kanzawa, Takao, additional, Kurihara, Hideyuki, additional, Ohmori, Sigehiro, additional, Hiroshi Kusunoki, Mitsugi Yoshinao, additional, Magarisawa, Satoshi, additional, Okabe, Shinichi, additional, Kujiraoka, Yuuji, additional, Tsuruoka, Shin, additional, Takeshita, Mikihiko, additional, Akira Matsumura, Tetsuya Yamamoto, additional, Uemura, Kazuya, additional, Tabata, Hitoshi, additional, Sonobe, Makoto, additional, Ryoji Yoshida, Masashi Nakatsukasa, additional, Shimoeda, Norifumi, additional, Kunimine, Hideo, additional, Ishihara, Masayuki, additional, Murai, Nozomu, additional, Murakami, Nobukuni, additional, Kidooka, Minoru, additional, Iwamoto, Yoshihiro, additional, Tenjin, Hiroshi, additional, Masahiko Takamasu, Kouji Shiga, additional, Mori, Nobuhito, additional, Kose, Shigeru, additional, Kohmura, Eiji, additional, Matsumoto, Keigo, additional, Sakaki, Takayuki, additional, Miyake, Hiroji, additional, Mabuchi, Eiichiro, additional, Yokota, Masayuki, additional, Yosihiro Kuga, Hideyuki Ohnishi, additional, Kimura, Mitsuru, additional, Masaaki Saiki, Osamu Narumi, additional, Nakajima, Norio, additional, Asahi, Minoru, additional, Koyama, Junji, additional, Noda, Shinya, additional, Iida, Junichi, additional, Fujita, Toyohisa, additional, Nakase, Hiroyuki, additional, Toru Hoshida, Hidehiro Hirabayashi, additional, Fujimoto, Takayoshi, additional, Nakao, Naoyuki, additional, Tanaka, Yoshiyuki, additional, Ozaki, Fuminori, additional, Nakamura, Yoshinari, additional, Miki, Kazuhito, additional, Watanabe, Takashi, additional, Hasegawa, Seiko, additional, Konno, Hiromu, additional, Takemura, Atsuhito, additional, Okubo, Atsuya, additional, Saito, Hitoshi, additional, Taizen Nakase, Tatsuya Ishikawa, additional, Toshio Sasajima, Hiroaki Shimizu, additional, Sasou, Masayuki, additional, Watanabe, Yoichi, additional, Kiyoshi Saito, Taku Sato, additional, Masahiro Satoh, Satoshi Taira, additional, Koizumi, Takayuki, additional, Shoji Mashiyama, Yasuhiro Suzuki, additional, Oikawa, Tomoyoshi, additional, Sonoda, Yukihiko, additional, Shinjiro Saito, Rei Kondo, additional, Shinoda, Atsuo, additional, Kamatsuka, Eiichiro, additional, So, Keiten, additional, Kinjo, Toshihiko, additional, Kennji Itou, Tooru Sasaki, additional, Hiroaki Shimizu, Hidenori Endo, additional, Karibe, Hirosi, additional, Takahashi, Kou, additional, Nakajima, Masayuki, additional, Watanabe, Kazuyoshi, additional, Takayama, Motohiro, additional, Komuro, Taro, additional, Fumio Suzuki, Hisao Hirai, additional, Suzuki, Hidenori, additional, Murata, Hiroto, additional, Miya, Fumitaka, additional, Kanamaru, Kenji, additional, Tamura, Akira, additional, Harada, Kiyoshi, additional, Fukazawa, Seiji, additional, Takehara, Seiya, additional, Watanabe, Yoshihiko, additional, Nakayama, Teiji, additional, Hiroshi Nagura, Haruhiko Sato, additional, Chiharu Tanoi, Shinji Amano, additional, Kuroda, Katsuhiro, additional, Morooka, Satoru, additional, Masashi Kitagawa, Takafumi Wataya, additional, Koide, Kazuo, additional, Tanigawara, Tetsuya, additional, Iwama, Toru, additional, Ito, Junki, additional, Noda, Shinji, additional, Kouno, Kazuyuki, additional, Kitazawa, Kazuo, additional, Toshiki Takemae, Yoshikazu Kusano, additional, Hokama, Masanobu, additional, Yoshihisa Nishiyama, Hiroki Sato, additional, Seguchi, Tatsuya, additional, Yoshihiko Inui, Sumio Kobayashi, additional, Oohigashi, Youji, additional, Muraoka, Shinsuke, additional, Miyatake, Masaki, additional, Nakagawa Shinichi, Kensuke Hayashida, additional, Inoue, Atsushi, additional, Sakai, Keiichi, additional, Yamaguchi, Shuhei, additional, Fusao Ikawa, Tatsuya Mizoue, additional, Hideki Irie, Gen Ishida, additional, Kagawa, Takato, additional, Namba, Yoichiro, additional, Nakashima, Hiroyuki, additional, Koji Abe, Isao Date, additional, Uno, Masaaki, additional, Sen Yamagata, Masaki Chin, additional, Soitiro Takao, Hidemiti Sasayama, additional, Kouji Muneda, Hideyuki Yoshida, additional, Watanebe, Akira, additional, Katou, Syouichi, additional, Hamada, Yasuhiro, additional, Nishizaki, Takafumi, additional, Yamashita, Katsuhiro, additional, Ryuji Nakamura, Takaharu Nakamura, additional, Wakabayashi, Shinichi, additional, Okazaki, Takahito, additional, Kurisu, Kaoru, additional, Matsumoto, Masayasu, additional, Katsuzo Kiya, Atsushi Tominaga, additional, Syuichi Oki, Masaaki Shibukawa, additional, Nakahara, Toshinori, additional, Okita, Shinji, additional, Torii, Tuyosi, additional, Kenjirou Fujiwara, Minoru Nakagawa, additional, Syuuhei Nishimura, Takashi Matsuoka, additional, Naoyuki Isobe, Osamu Hamasaki, additional, Shinji Nagahiro, Junichiro Satomi, additional, Agawa, Masahito, additional, Oka, Hirofumi, additional, Yoshimura, Kunikazu, additional, Kato, Tsutomu, additional, Satoshi Minoshima, Nobuaki Kobayasi, additional, Mikuni, Nobuhiro, additional, Tanikawa, Rokuya, additional, Sasaki, Jyunkou, additional, Otawara, Yasunari, additional, Tominaga, Teiji, additional, Sasaki, Tatsuya, additional, Takemura, Sunao, additional, Kawakami, Masahisa, additional, Ihara, Satoshi, additional, Shibata, Yasushi, additional, Saegusa, Takashi, additional, Iuchi, Toshihiko, additional, Ito, Chiaki, additional, Okuda, Osamu, additional, Yoshida, Kazunari, additional, Masateru Katayama, Sadao Suga, additional, Akihiro, Oikawa, additional, Miura, Naohisa, additional, Ota, Takahiro, additional, Kumabe, Toshihiro, additional, Suzuki, Sachio, additional, Kumagai, Takashi, additional, Nishimaki, Keiichi, additional, Hongo, Kazuhiro, additional, Shigeta, Hiroaki, additional, Hattori, Kazuyoshi, additional, Uozumi, Yoichi, additional, Nakahara, Norimoto, additional, Hashimoto, Nobukazu, additional, Shu Imai, Shinichi Shirakami, additional, Okumura, Yoshinari, additional, Kazuhiro Yokoyama, Ryo Tamaki, additional, Miyamoto, Susumu, additional, Yamamoto, Kazuo, additional, Ichioka, Tsugumichi, additional, Inoue, Tsuyoshi, additional, Kinoshita, Manabu, additional, Saitoh, Minoru, additional, Aihara, Hideo, additional, Miyake, Hajimu, additional, Tukasa Nishiura, Kotaro Ogihara, additional, Nishino, Shigeki, additional, Miyoshi, Yasuyuki, additional, Arisawa, Tadashi, additional, Shoji Tsuchimoto, Shigeru Daido, additional, Kinoshita, Kimihisa, additional, Keisuke Migita, Kiyoshi Yuki, additional, Akatsuka, Keiichi, additional, Fujisawa, Hirosuke, additional, Shono, Tadahisa, additional, Tsugu, Hitoshi, additional, Hayashi, Shuji, additional, Toshio Matsushima, Tatsuya Abe, additional, Nakashima, Susumu, additional, Tuji, Takehisa, additional, Kaga, Akihiko, additional, Kanemaru, Reizou, additional, Takasaki, Koji, additional, Imamura, Junichi, additional, Noha, Masahiro, additional, Watanabe, Saburo, additional, Sakai, Nobuyuki, additional, Hiroaki Minami, Yasuhisa Yoshida, additional, Okumura, Tomoyoshi, additional, Nishimura, Shinjitsu, additional, Numazawa, Shinichi, additional, Masanori Tsutsumi, Kiyoshi Kazekawa, additional, Fukuyama, Kouzou, additional, and Fujimoto, Yasuhiro, additional

Published
2019
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