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1. Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium

Author

Kumar, Shiva, Gadano, Adrián, Marciano, Sebastián, Tudehope, Fiona, Prudence, Alexander, Gibson, Robert, Zekry, Amany, Doyle, Adam, Si, Hooi Ling, Kim, Yu Sung, Gofton, Cameron, Riordan, Stephen, MacQuillan, Gerry, Al-Tamimi, Hala, Michalczuk, Matheus, Farias, Alberto, Zitelli, Patricia, Pereira, Gustavo, Victor, Livia, Bera, Chinmay, Faisal, Nabiha, Dahiya, Monica, Tandon, Puneeta, Lohoues, Marie Jeanne, Lah, Ponan Claude Regis, Benítez, Carlos, Arrese, Marco, Guan, Jing, Xian, Yongchao, Zhu, Chuanwu, Wang, Yingling, Su, Man, Su, Minghua, Wang, Xinrui, Gao, Yanhang, Peng, Feng, Jiang, Yongfang, Zhao, Caiyan, Wang, Wei, Yin, Dedong, Wang, Lei, Lu, Mingqin, Cai, Yijing, Guo, Feng, Wang, Xiaozhong, Zhang, Ningping, Zhang, Wanqin, Dong, Fuchen, Li, Hai, Liu, Jing, Zheng, Xin, Tang, Hong, Yan, Libo, Xu, Bin, Wei, Linlin, Xu, Zhen, Gao, Zhiliang, Gao, Haibing, Lin, Minghua, Rao, Qunfang, Wu, Xiaoping, Li, Beiling, Chen, Jinjun, Liu, Chenghai, Zhang, Yanyun, Deng, Huan, Hu, Peng, Wang, Jian, Li, Jie, Bettinger, Dominik, Schultheiß, Michael, Belimi, Hibat Allah, Debzi, Nabil, Mostafa, Alaa, Fouad, Yasser, Fisseha, Henok, Venkatachalapathy, Suresh Vasan, Aravinthan, Aloysious D, Rajoriya, Neil, Faulkes, Rosemary, Leith, Damien, Forrest, Ewan, Danielle, Adebayo, Kennedy, James, Yung, Diana, Alexopoulou, Alexandra, Mani, Iliana, Fung, James, Katchman, Helena, Rabinowich, Liane, Jhaveri, Ajay, Nagral, Aabha, Kulkarni, Anand, Sharma, Mithun, Sarin, Shiv K, Goel, Ashish, Eapen, C E, Duseja, Ajay, Gandotra, Akash, Saraya, Anoop, yegurla, Jatin, Jothimani, Dinesh, Rela, Mohammad, Arora, Anil, Kumar, Ashish, Roy, Akash, Dhiman, R K, Anand, A C, Praharaj, Dibyalochan, Cabrera, Araceli Bravo, Hueso, Sarai Gonzalez, Hérnandez, José Luis Pérez, Gutierrez, Oscar Morales, Ramos-Pineda, Abraham, Zazueta, Godolfino Miranda, Barradas, Mauricio Castillo, Made, Lilian Torres, Velazquez, Rene Male, Félix-Tellez, Francisco, Velasco, José Antonio Velarde-Ruiz, Cordova-Gallardo, Jacqueline, Rajaram, Ruveena, Afendi, Nik Arsyad Nik Muhamad, Nyam, David P, Okeke, Edith N, Allam, Dalia, Patwa, Yashwi Haresh Kumar, Tan, Hiang Keat, Lun, Liou Wei, Ho, Wei Ling Danielle, Wong, Yu Jun, Thanapirom, Kessarin, Teerasarntipan, Tongluk, Haktaniyan, Busra, Gunduz, Feyza, Aslan, Rahmi, Yildirim, Abdullah Emre, Barutcu, Sezgin, Uysal, Alper, Karasu, Zeki, Ucbilek, Enver, Kosay, Tolga, Dinçer, Dinç, Adanır, Haydar, Albhaisi, Somaya, Fallahadeh, Mohammad Amin, Asrani, Sumeet, Reddy, K Rajender, Shaw, Jawaid, Vargas, Hugo, Filipek, Natalia, Biggins, Scott W, Thuluvath, Paul, Sheshadri, Somya, Wegermann, Kara, Kappus, Matthew, Keaveny, Andrew, Rojo, Andres, Negrillo, Ricardo Cabello, Verna, Elizabeth, Cao, Zhujun, Wong, Florence, Choudhury, Ashok K, Kamath, Patrick S, Topazian, Mark, Torre, Aldo, Hayes, Peter C, George, Jacob, Idilman, Ramazan, Seto, Wai-Kay, Desalegn, Hailemichael, Alvares-da-Silva, Mario Reis, Bush, Brian J, Thacker, Leroy R, Xie, Qing, and Bajaj, Jasmohan S

Published
2024
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8. Global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium

Author

Sarin, Shiv K, Kumar, Shiva, Marciano, Sebastián, Gadano, Adrián, Tudehope, Fiona, Gibson, Robert, Prudence, Alexander, Doyle, Adam, Si, Hooi Ling, Riordan, Stephen, Farias, Alberto, Zitelli, Patricia, Bera, Chinmay, Faisal, Nabiha, Tandon, Puneeta, Dahiya, Monica, Lohoues, Marie Jeanne, Lah, Ponan Claude Regis, Benítez, Carlos, Arrese, Marco, Xian, Yongchao, Guan, Jin, Zhu, Chuanwu, Wang, Yingling, Su, Minghua, Su, Man, Gao, Yanhang, Wang, Xinrui, Jiang, Yongfang, Peng, Feng, Zhao, Caiyan, Wang, Wei, Wang, Lei, Yin, Dedong, Lu, Mingqin, Cai, Yijing, Zhang, Ningping, Zhang, Wanqin, Li, Hai, Dong, Fuchen, Zheng, Xin, Liu, Jing, Tang, Hong, Yan, Libo, Xu, Bin, Wei, Linlin, Gao, Zhiliang, Xu, Zhen, Lin, Minghua, Gao, Haibin, Chen, Jinjun, Li, Beiling, Liu, Chenghai, Zhang, Yanyun, Hu, Peng, Deng, Huan, Belimi, Hibat Allah, Debzi, Nabil, Fisseha, Henok, Aravinthan, Aloysious D, Venkatachalapathy, Suresh Vasan, Rajoriya, Neil, Faulkes, Rosemary, Leith, Damien, Forrest, Ewan, Adebayo, Danielle, Kennedy, James, Yung, Diana, Seto, Wai-Kay, Fung, James, Katchman, Helena, Rabinowich, Liane, Nagral, Aabha, Jhaveri, Ajay, Kulkarni, Anand, Sharma, Mithun, Eapen, C E, Goel, Ashish, Gandotra, Akash, Duseja, Ajay, Saraya, Anoop, Yegurla, Jatin, Rela, Mohamed, Jothimani, Dinesh, Arora, Anil, Kumar, Ashish, Dhiman, Radha Krishan, Roy, Akash, Anand, Anil C, Praharaj, Dibyalochan, Hueso, Sarai Gonzalez, Cabrera, Araceli Bravo, Pérez Hérnandez, José Luis, Gutierrez, Oscar Morales, Miranda Zazueta, Godolfino, Ramos-Pineda, Abraham, Castillo Barradas, Mauricio, Velazquez, Rene Male, Made, Lilian Torres, Velarde-Ruiz Velasco, José Antonio, Félix-Tellez, Francisco, Cordova-Gallardo, Jacqueline, Rajaram, Ruveena, Nik Muhamad Afendi, Nik Arsyad, Okeke, Edith N, Nyam, David P, Allam, Dalia, Kumar Patwa, Yashwi Haresh, Tan, Hiang Keat, Liou, Wei Lun, Treeprasertsuk, Sombat, Wejnaruemarn, Salisa, Haktaniyan, Busra, Gunduz, Feyza, Aslan, Rahmi, Yildirim, Abdullah Emre, Barutcu, Sezgin, Karasu, Zeki, Uysal, Alper, Ucbilek, Enver, Kosay, Tolga, Adanir, Haydar, Dinçer, Dinç, Albhaisi, Somaya, Asrani, Sumeet, Fallahadeh, Mohammad Amin, Reddy, K Rajender, Rahematpura, Suditi, Shaw, Jawaid, Vargas, Hugo E., Bayne, David, Biggins, Scott W, Filipek, Natalia, Thuluvath, Paul, Sheshadri, Somya, Keaveny, Andrew, Duarte Rojo, Andres, Cabello Negrillo, Ricardo, Bajaj, Jasmohan S, Choudhury, Ashok K, Xie, Qing, Kamath, Patrick S, Topazian, Mark, Hayes, Peter C, Torre, Aldo, Desalegn, Hailemichael, Idilman, Ramazan, Cao, Zhujun, Alvares-da-Silva, Mario R, George, Jacob, Bush, Brian J, Thacker, Leroy R, and Wong, Florence

Published
2023
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18. Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium

Author

Cao, Zhujun, Wong, Florence, Choudhury, Ashok K, Kamath, Patrick S, Topazian, Mark, Torre, Aldo, Hayes, Peter C, George, Jacob, Idilman, Ramazan, Seto, Wai-Kay, Desalegn, Hailemichael, Alvares-da-Silva, Mario Reis, Bush, Brian J, Thacker, Leroy R, Xie, Qing, Bajaj, Jasmohan S, Kumar, Shiva, Gadano, Adrián, Marciano, Sebastián, Tudehope, Fiona, Prudence, Alexander, Gibson, Robert, Zekry, Amany, Doyle, Adam, Si, Hooi Ling, Kim, Yu Sung, Gofton, Cameron, Riordan, Stephen, MacQuillan, Gerry, Al-Tamimi, Hala, Michalczuk, Matheus, Farias, Alberto, Zitelli, Patricia, Pereira, Gustavo, Victor, Livia, Bera, Chinmay, Faisal, Nabiha, Dahiya, Monica, Tandon, Puneeta, Lohoues, Marie Jeanne, Lah, Ponan Claude Regis, Benítez, Carlos, Arrese, Marco, Guan, Jing, Xian, Yongchao, Zhu, Chuanwu, Wang, Yingling, Su, Man, Su, Minghua, Wang, Xinrui, Gao, Yanhang, Peng, Feng, Jiang, Yongfang, Zhao, Caiyan, Wang, Wei, Yin, Dedong, Wang, Lei, Lu, Mingqin, Cai, Yijing, Guo, Feng, Wang, Xiaozhong, Zhang, Ningping, Zhang, Wanqin, Dong, Fuchen, Li, Hai, Liu, Jing, Zheng, Xin, Tang, Hong, Yan, Libo, Xu, Bin, Wei, Linlin, Xu, Zhen, Gao, Zhiliang, Gao, Haibing, Lin, Minghua, Rao, Qunfang, Wu, Xiaoping, Li, Beiling, Chen, Jinjun, Liu, Chenghai, Zhang, Yanyun, Deng, Huan, Hu, Peng, Wang, Jian, Li, Jie, Bettinger, Dominik, Schultheiß, Michael, Belimi, Hibat Allah, Debzi, Nabil, Mostafa, Alaa, Fouad, Yasser, Fisseha, Henok, Venkatachalapathy, Suresh Vasan, Aravinthan, Aloysious D, Rajoriya, Neil, Faulkes, Rosemary, Leith, Damien, Forrest, Ewan, Danielle, Adebayo, Kennedy, James, Yung, Diana, Alexopoulou, Alexandra, Mani, Iliana, Fung, James, Katchman, Helena, Rabinowich, Liane, Jhaveri, Ajay, Nagral, Aabha, Kulkarni, Anand, Sharma, Mithun, Sarin, Shiv K, Goel, Ashish, Eapen, C E, Duseja, Ajay, Gandotra, Akash, Saraya, Anoop, yegurla, Jatin, Jothimani, Dinesh, Rela, Mohammad, Arora, Anil, Kumar, Ashish, Roy, Akash, Dhiman, R K, Anand, A C, Praharaj, Dibyalochan, Cabrera, Araceli Bravo, Hueso, Sarai Gonzalez, Hérnandez, José Luis Pérez, Gutierrez, Oscar Morales, Ramos-Pineda, Abraham, Zazueta, Godolfino Miranda, Barradas, Mauricio Castillo, Made, Lilian Torres, Velazquez, Rene Male, Félix-Tellez, Francisco, Velasco, José Antonio Velarde-Ruiz, Cordova-Gallardo, Jacqueline, Rajaram, Ruveena, Afendi, Nik Arsyad Nik Muhamad, Nyam, David P, Okeke, Edith N, Allam, Dalia, Patwa, Yashwi Haresh Kumar, Tan, Hiang Keat, Lun, Liou Wei, Ho, Wei Ling Danielle, Wong, Yu Jun, Thanapirom, Kessarin, Teerasarntipan, Tongluk, Haktaniyan, Busra, Gunduz, Feyza, Aslan, Rahmi, Yildirim, Abdullah Emre, Barutcu, Sezgin, Uysal, Alper, Karasu, Zeki, Ucbilek, Enver, Kosay, Tolga, Dinçer, Dinç, Adanır, Haydar, Albhaisi, Somaya, Fallahadeh, Mohammad Amin, Asrani, Sumeet, Reddy, K Rajender, Shaw, Jawaid, Vargas, Hugo, Filipek, Natalia, Biggins, Scott W, Thuluvath, Paul, Sheshadri, Somya, Wegermann, Kara, Kappus, Matthew, Keaveny, Andrew, Rojo, Andres, Negrillo, Ricardo Cabello, and Verna, Elizabeth

Abstract

Infections have a poor prognosis in inpatients with cirrhosis. We aimed to determine regional variations in infections and their association with clinical outcomes in a global cohort of inpatients with cirrhosis.

Published
2024
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22. Hepatitis C Virus Antiviral Drug Resistance and Salvage Therapy Outcomes Across Australia

Author

Wang, Dao Sen, primary, Phu, Amy, additional, McKee, Kristen, additional, Strasser, Simone I, additional, Sheils, Sinead, additional, Weltman, Martin, additional, Sellar, Sue, additional, Davis, Joshua S, additional, Young, Mel, additional, Braund, Alicia, additional, Farrell, Geoffrey C, additional, Blunn, Anne, additional, Harding, Damian, additional, Ralton, Lucy, additional, Muller, Kate, additional, Davison, Scott A, additional, Shaw, David, additional, Wood, Marnie, additional, Hajkowicz, Krispin, additional, Skolen, Richard, additional, Davies, Jane, additional, Tate-Baker, Jaclyn, additional, Doyle, Adam, additional, Tuma, Rhoda, additional, Hazeldine, Simon, additional, Lam, Wendy, additional, Edmiston, Natalie, additional, Zohrab, Krista, additional, Pratt, William, additional, Watson, Belinda, additional, Zekry, Amany, additional, Stephens, Carlie, additional, Clark, Paul J, additional, Day, Melany, additional, Park, Gordon, additional, Kim, Hami, additional, Wilson, Mark, additional, McGarity, Bruce, additional, Menzies, Natalie, additional, Russell, Darren, additional, Lam, Thao, additional, Boyd, Peter, additional, Kok, Jen, additional, George, Jacob, additional, and Douglas, Mark W, additional

Published
2024
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25. Decreasing prevalence of centers meeting the Society for Vascular Surgery abdominal aortic aneurysm guidelines in the United States

Author

Ramirez, Joel L., primary, Matthay, Zachary A., additional, Lancaster, Elizabeth, additional, Smith, Eric J.T., additional, Gasper, Warren J., additional, Zarkowsky, Devin S., additional, Doyle, Adam J., additional, Patel, Virendra I., additional, Schanzer, Andres, additional, Conte, Michael S., additional, and Iannuzzi, James C., additional

Published
2024
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28. Outcomes of radiofrequency ablation as first-line therapy for hepatocellular carcinoma less than 3 cm in potentially transplantable patients

Author

Doyle, Adam, Gorgen, Andre, Muaddi, Hala, Aravinthan, Aloysious D., Issachar, Assaf, Mironov, Oleg, Zhang, Wei, Kachura, John, Beecroft, Robert, Cleary, Sean P., Ghanekar, Anand, Greig, Paul D., McGilvray, Ian D., Selzner, Markus, Cattral, Mark S., Grant, David R., Lilly, Leslie B., Selzner, Nazia, Renner, Eberhard L., Sherman, Morris, and Sapisochin, Gonzalo

Published
2019
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31. Platelet olfactory receptor activation limits platelet reactivity and growth of aortic aneurysms

Author

Morrell, Craig N., Mix, Doran, Aggarwal, Anu, Bhandari, Rohan, Godwin, Matthew, Owens, Phillip, III, Lyden, Sean P., Doyle, Adam, Krauel, Krystin, Rondina, Matthew T., Mohan, Amy, Lowenstein, Charles J., Shim, Sharon, Stauffer, Shaun, Josyula, Vara Prasad, Ture, Sara K., Yule, David I., Wagner, Larry E., III, Ashton, John ., Elbadawi, Ayman, and Cameron, Scott J.

Subjects
Olfactory receptors -- Health aspects -- Physiological aspects, Cardiovascular research, Drug resistance -- Research, Aortic aneurysms -- Development and progression -- Drug therapy, Cellular signal transduction -- Research, Blood platelets -- Activation, Health care industry
Abstract

As blood transitions from steady laminar flow (S-flow) in healthy arteries to disturbed flow (D-flow) in aneurysmal arteries, platelets are subjected to external forces. Biomechanical platelet activation is incompletely understood and is a potential mechanism behind antiplatelet medication resistance. Although it has been demonstrated that antiplatelet drugs suppress the growth of abdominal aortic aneurysms (AAA) in patients, we found that a certain degree of platelet reactivity persisted in spite of aspirin therapy, urging us to consider additional antiplatelet therapeutic targets. Transcriptomic profiling of platelets from patients with AAA revealed upregulation of a signal transduction pathway common to olfactory receptors, and this was explored as a mediator of AAA progression. Healthy platelets subjected to D-flow ex vivo, platelets from patients with AAA, and platelets in murine models of AAA demonstrated increased membrane olfactory receptor 2L13 (OR2L13) expression. A drug screen identified a molecule activating platelet OR2L13, which limited both biochemical and biomechanical platelet activation as well as AAA growth. This observation was further supported by selective deletion of the OR2L13 ortholog in a murine model of AAA that accelerated aortic aneurysm growth and rupture. These studies revealed that olfactory receptors regulate platelet activation in AAA and aneurysmal progression through platelet-derived mediators of aortic remodeling., Introduction Remodeling of the infrarenal aorta that results in abdominal aortic aneurysms (AAA) affects millions of individuals and carries an extraordinarily high out-of-hospital mortality rate if this pathological process progresses [...]

Published
2022
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33. Decreasing Prevalence of Centers Meeting the Society for Vascular Surgery Abdominal Aortic Aneurysm Guidelines in the United States

Author

Ramirez, Joel L., primary, Matthay, Zachary A., additional, Lancaster, Elizabeth, additional, Smith, Eric J.T., additional, Gasper, Warren J., additional, Zarkowsky, Devin S., additional, Doyle, Adam J., additional, Patel, Virendra I., additional, Schanzer, Andres, additional, Conte, Michael S., additional, and Iannuzzi, James C., additional

Published
2023
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34. Decreasing prevalence of centers meeting the Society for Vascular Surgery abdominal aortic aneurysm guidelines in the United States.

Author

Ramirez, Joel L., Matthay, Zachary A., Lancaster, Elizabeth, Smith, Eric J.T., Gasper, Warren J., Zarkowsky, Devin S., Doyle, Adam J., Patel, Virendra I., Schanzer, Andres, Conte, Michael S., and Iannuzzi, James C.

Abstract

Based on data supporting a volume-outcome relationship in elective aortic aneurysm repair, the Society of Vascular Surgery (SVS) guidelines recommend that endovascular aortic repair (EVAR) be localized to centers that perform ≥10 operations annually and have a perioperative mortality and conversion-to-open rate of ≤2% and that open aortic repair (OAR) be localized to centers that perform ≥10 open aortic operations annually and have a perioperative mortality ≤5%. However, the number and distribution of centers meeting the SVS criteria remains unclear. This study aimed to estimate the temporal trends and geographic distribution of Centers Meeting the SVS Aortic Guidelines (CMAG) in the United States. The SVS Vascular Quality Initiative was queried for all OAR, aortic bypasses, and EVAR from 2011 to 2019. Annual OAR and EVAR volume, 30-day elective operative mortality for OAR or EVAR, and EVAR conversion-to-open rate for all centers were calculated. The SVS guidelines for OAR and EVAR, individually and combined, were applied to each institution leading to a CMAG designation. The proportion of CMAGs by region (West, Midwest, South, and Northeast) were compared by year using a χ2 test. Temporal trends were estimated using a multivariable logistic regression for CMAG, adjusting by region. Overall, 67,865 patients (49,264 EVAR; 11,010 OAR; 7591 aortic bypasses) at 336 institutions were examined. The proportion of EVAR CMAGs increased nationally by 1.7% annually from 51.6% (n = 33/64) in 2011 to 67.1% (n = 190/283) in 2019 (β =.05; 95% confidence interval [CI], 0.01-0.09; P =.02). The proportion of EVAR CMAGs across regions ranged from 27.3% to 66.7% in 2011 to 63.9% to 72.9% in 2019. In contrast, the proportion of OAR CMAGs has decreased nationally by 1.8% annually from 32.8% (n = 21/64) in 2011 to 16.3% (n = 46/283) in 2019 (β = −.14; 95% CI, −0.19 to −0.10; P <.01). Combined EVAR and OAR CMAGs were even less frequent and decreased by 1.5% annually from 26.6% (n = 17/64) in 2011 to 13.1% (n = 37/283) in 2019 (β = −.12; 95% CI, −0.17 to −0.07; P <.01). In 2019, there was no significant difference in regional variation of the proportion of combined EVAR and OAR CMAGs (P =.82). Although an increasing proportion of institutions nationally meet the SVS guidelines for EVAR, a smaller proportion meet them for OAR, with a concerning downward trend. These data question whether we can safely offer OAR at most institutions, have important implications about sufficient OAR exposure for trainees, and support regionalization of OAR. [ABSTRACT FROM AUTHOR]

Published
2024
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36. Liver Transplantation is Equally Effective as a Salvage Therapy for Patients with Hepatocellular Carcinoma Recurrence Following Radiofrequency Ablation or Liver Resection with Curative Intent

Author

Muaddi, Hala, Al-Adra, David P., Beecroft, Rob, Ghanekar, Anand, Moulton, Carol-Anne, Doyle, Adam, Selzner, Markus, Wei, Alice, McGilvray, Ian D., Gallinger, Steven, Grant, David R., Cattral, Mark S., Greig, Paul D., Kachura, John, Cleary, Sean P., and Sapisochin, Gonzalo

Published
2018
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39. Nosocomial infections in cirrhosis are unpredictable and vary based on region of the world: CLEARED study

Author

Bajaj, Jasmohan S, primary, Wong, Florence, additional, Xie, Qing, additional, Kamath, Patrick S., additional, Topazian, Mark, additional, Sarin, Shiv Kumar, additional, Kumar, Shiva, additional, Marciano, Sebastián, additional, Tudehope, Fiona, additional, Gibson, Robert, additional, Doyle, Adam, additional, Riordan, Stephen, additional, Farias, Alberto Queiroz, additional, Faisal, Nabiha, additional, Tandon, Puneeta, additional, Lohoues, Marie Jeanne, additional, Benitez, Carlos, additional, Xian, Yongchao, additional, Zhu, Chuanwu, additional, Su, Minghua, additional, Jiang, Yongfang, additional, Zhao, Caiyan, additional, Wang, Lei, additional, Lu, Mingqin, additional, Zhang, Ning-Ping, additional, Li, Hai, additional, Zheng, Xin, additional, Tang, Hong, additional, Xu, Bin, additional, gao, zhiliang, additional, Lin, minghua, additional, Chen, Jinjun, additional, Liu, ChengHai, additional, Hu, Peng, additional, Allah, Belimi Hibat, additional, Fisseha, Henok, additional, Aravinthan, Aloysious, additional, Rajoriya, Neil, additional, Leith, Damien, additional, Adebayo, Danielle, additional, Yung, Diana, additional, Seto, Wai-Kay, additional, Katchman, Helena, additional, Nagral, Abha, additional, Kulkarni, Anand, additional, Eapen, CE, additional, Duseja, Ajay Kumar, additional, Saraya, Anoop, additional, Rela, Mohd., additional, Anora, Anil, additional, Dhiman, Radha Krishan, additional, Anand, Anil Chandra, additional, González-Huezo, Maria Sarai, additional, Perez Hernandez, Jose Luis, additional, Zazueta, Godolfino Miranda, additional, Castillo, Mauricio, additional, Velazquez, René Malé, additional, Velarde-Ruiz Velasco, Jose Antonio, additional, Cordova, Jacqueline, additional, Bhavani, Ruveena, additional, Okeke, Edith, additional, Allam, Dalia, additional, Tan, Hiang Keat, additional, Treeprasertsuk, Sombat, additional, Haktaniyan, Busra, additional, Gunduz, Feyza, additional, Yıldırım, Abdullah Emre, additional, Karasu, Zeki, additional, Ucbilek, Enver, additional, Adanir, Haydar, additional, Albhaisi, Somaya, additional, Asrani, Sumeet, additional, Reddy, K. Rajender, additional, Shaw, Jawaid, additional, Vargas, Hugo, additional, Biggins, Scott, additional, Thuluvath, Paul J., additional, Keaveny, Andrew, additional, Hayes, Peter, additional, Torre, Aldo, additional, Idilman, Ramazan, additional, Cao, Zhujun, additional, Álvares-da-Silva, Mario, additional, George, Jacob, additional, Desalegn, Hailemichael, additional, Bush, Brian, additional, Thacker, Leroy, additional, Andres, Duarte Rojo, additional, and Choudhury, Ashok, additional

Published
2023
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40. Global disparities in mortality and liver transplantation in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium

Author

Bajaj, Jasmohan S, primary, Choudhury, Ashok K, additional, Xie, Qing, additional, Kamath, Patrick S, additional, Topazian, Mark, additional, Hayes, Peter C, additional, Torre, Aldo, additional, Desalegn, Hailemichael, additional, Idilman, Ramazan, additional, Cao, Zhujun, additional, Alvares-da-Silva, Mario R, additional, George, Jacob, additional, Bush, Brian J, additional, Thacker, Leroy R, additional, Wong, Florence, additional, Sarin, Shiv K, additional, Kumar, Shiva, additional, Marciano, Sebastián, additional, Gadano, Adrián, additional, Tudehope, Fiona, additional, Gibson, Robert, additional, Prudence, Alexander, additional, Doyle, Adam, additional, Si, Hooi Ling, additional, Riordan, Stephen, additional, Farias, Alberto, additional, Zitelli, Patricia, additional, Bera, Chinmay, additional, Faisal, Nabiha, additional, Tandon, Puneeta, additional, Dahiya, Monica, additional, Lohoues, Marie Jeanne, additional, Lah, Ponan Claude Regis, additional, Benítez, Carlos, additional, Arrese, Marco, additional, Xian, Yongchao, additional, Guan, Jin, additional, Zhu, Chuanwu, additional, Wang, Yingling, additional, Su, Minghua, additional, Su, Man, additional, Gao, Yanhang, additional, Wang, Xinrui, additional, Jiang, Yongfang, additional, Peng, Feng, additional, Zhao, Caiyan, additional, Wang, Wei, additional, Wang, Lei, additional, Yin, Dedong, additional, Lu, Mingqin, additional, Cai, Yijing, additional, Zhang, Ningping, additional, Zhang, Wanqin, additional, Li, Hai, additional, Dong, Fuchen, additional, Zheng, Xin, additional, Liu, Jing, additional, Tang, Hong, additional, Yan, Libo, additional, Xu, Bin, additional, Wei, Linlin, additional, Gao, Zhiliang, additional, Xu, Zhen, additional, Lin, Minghua, additional, Gao, Haibin, additional, Chen, Jinjun, additional, Li, Beiling, additional, Liu, Chenghai, additional, Zhang, Yanyun, additional, Hu, Peng, additional, Deng, Huan, additional, Belimi, Hibat Allah, additional, Debzi, Nabil, additional, Fisseha, Henok, additional, Aravinthan, Aloysious D, additional, Venkatachalapathy, Suresh Vasan, additional, Rajoriya, Neil, additional, Faulkes, Rosemary, additional, Leith, Damien, additional, Forrest, Ewan, additional, Adebayo, Danielle, additional, Kennedy, James, additional, Yung, Diana, additional, Seto, Wai-Kay, additional, Fung, James, additional, Katchman, Helena, additional, Rabinowich, Liane, additional, Nagral, Aabha, additional, Jhaveri, Ajay, additional, Kulkarni, Anand, additional, Sharma, Mithun, additional, Eapen, C E, additional, Goel, Ashish, additional, Gandotra, Akash, additional, Duseja, Ajay, additional, Saraya, Anoop, additional, Yegurla, Jatin, additional, Rela, Mohamed, additional, Jothimani, Dinesh, additional, Arora, Anil, additional, Kumar, Ashish, additional, Dhiman, Radha Krishan, additional, Roy, Akash, additional, Anand, Anil C, additional, Praharaj, Dibyalochan, additional, Hueso, Sarai Gonzalez, additional, Cabrera, Araceli Bravo, additional, Pérez Hérnandez, José Luis, additional, Gutierrez, Oscar Morales, additional, Miranda Zazueta, Godolfino, additional, Ramos-Pineda, Abraham, additional, Castillo Barradas, Mauricio, additional, Velazquez, Rene Male, additional, Made, Lilian Torres, additional, Velarde-Ruiz Velasco, José Antonio, additional, Félix-Tellez, Francisco, additional, Cordova-Gallardo, Jacqueline, additional, Rajaram, Ruveena, additional, Nik Muhamad Afendi, Nik Arsyad, additional, Okeke, Edith N, additional, Nyam, David P, additional, Allam, Dalia, additional, Kumar Patwa, Yashwi Haresh, additional, Tan, Hiang Keat, additional, Liou, Wei Lun, additional, Treeprasertsuk, Sombat, additional, Wejnaruemarn, Salisa, additional, Haktaniyan, Busra, additional, Gunduz, Feyza, additional, Aslan, Rahmi, additional, Yildirim, Abdullah Emre, additional, Barutcu, Sezgin, additional, Karasu, Zeki, additional, Uysal, Alper, additional, Ucbilek, Enver, additional, Kosay, Tolga, additional, Adanir, Haydar, additional, Dinçer, Dinç, additional, Albhaisi, Somaya, additional, Asrani, Sumeet, additional, Fallahadeh, Mohammad Amin, additional, Reddy, K Rajender, additional, Rahematpura, Suditi, additional, Shaw, Jawaid, additional, Vargas, Hugo E., additional, Bayne, David, additional, Biggins, Scott W, additional, Filipek, Natalia, additional, Thuluvath, Paul, additional, Sheshadri, Somya, additional, Keaveny, Andrew, additional, Duarte Rojo, Andres, additional, and Cabello Negrillo, Ricardo, additional

Published
2023
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43. Long-term value in open and endovascular repair of chronic mesenteric ischemia.

Author

Lehane, Daniel, Geiger, Joshua, Kedwai, Baqir, Zottola, Zachary, Newhall, Karina, Mix, Doran, Doyle, Adam, and Stoner, Michael

Abstract

Guidelines recommend open revascularization (OR) over endovascular revascularization (ER) for the treatment of chronic mesenteric ischemia (CMI) for younger, healthier patients. However, little is known about the long-term costs of these recommendations with respect to patients' overall life expectancy. This study investigated whether 5-year value differs between these treatment modalities. Patient data were extracted from the Statewide Planning and Research Cooperative System, the New York statewide all-payor database containing demographics, diagnoses, treatments, and charges. The database was queried for patients with an International Classification of Diseases , ninth revision, code for CMI, with the specific exclusion of acute ischemia cases. A propensity score match was performed using the Charlson Comorbidity Index, age, sex, race, renal status, and pulmonary disease for the final cohort of patients. Multiple linear regression and mixed effects linear regression were used to determine factors associated with 5-year value, calculated as life-years/$100k in charges. Charges were gathered from the index admission and subsequent admissions for acute or CMI, mesenteric angiography, or follow-up reintervention. Kaplan-Meier estimation was performed for survival and reintervention-free survival. From 2000 to 2014, 875 patients underwent intervention for CMI. Of those meeting inclusion criteria, 209 (28.1%) underwent OR and 535 (71.9%) ER. After propensity score matching (n = 209 in each group), the ER group showed higher value at 5 years after the procedure (8.04 ± 11.42 life-years/$100k charges vs 4.89 ± 5.28 life-years/$100k charges; P <.01). More patients underwent reintervention in the ER group (37 patients vs 17 patients; P <.01), with 55 reinterventions in the ER group and 19 in the OR group (P <.01). Multiple linear regression analysis showed that age, congestive heart failure, dysrhythmia, cancer, and days spent in the intensive care unit were negatively associated with value at 5 years, whereas ER was positively associated. Survival was 59.6 ± 3.76% vs 62.3% ± 3.49% at 5 years (P =.91), and reintervention-free survival was 43.7 ± 3.86% vs 58.1 ± 3.53% (P =.04), for ER and OR respectively. Despite increased reinterventions and lower reintervention-free survival, the value for patients with CMI was higher in those who underwent ER in the largest propensity score-matched cohort to date looking at long-term value. Factors negatively associated with value were OR, age, days in intensive care, congestive heart failure, dysrhythmia, and cancer. In patients with amenable anatomy, ER is validated as the first-choice treatment for CMI based on the superior procedural value. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Liver Transplantation is a Preferable Alternative to Palliative Therapy for Selected Patients with Advanced Hepatocellular Carcinoma

Author

Aravinthan, Aloysious D., Bruni, Silvio G., Doyle, Adam C., Thein, Hla-Hla, Goldaracena, Nicolas, Issachar, Assaf, Lilly, Leslie B., Selzner, Nazia, Bhat, Mamatha, Sreeharsha, Boraiah, Selzner, Markus, Ghanekar, Anand, Cattral, Mark S., McGilvray, Ian D., Greig, Paul D., Renner, Eberhard L., Grant, David R., and Sapisochin, Gonzalo

Published
2017
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