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1. Effect of Opioids vs NSAIDs and Larger vs Smaller Chest Tube Size on Pain Control and Pleurodesis Efficacy Among Patients With Malignant Pleural Effusion: The TIME1 Randomized Clinical Trial

Author

Rahman, Najib M., Pepperell, Justin, Rehal, Sunita, Saba, Tarek, Tang, Augustine, Ali, Nabeel, West, Alex, Hettiarachchi, Gihan, Mukherjee, Dipak, Samuel, Johnson, Bentley, Andrew, Dowson, Lee, Miles, Jonathan, Ryan, C. Frank, Yoneda, Ken Y., Chauhan, Anoop, Corcoran, John P., Psallidas, Ioannis, Wrightson, John M., Hallifax, Rob, Davies, Helen E., Lee, Y. C. Gary, Dobson, Melissa, Hedley, Emma L., Seaton, Douglas, Russell, Nicky, Chapman, Margaret, McFadyen, Bethan M., Shaw, Rachel A., Davies, Robert J. O., Maskell, Nick A., Nunn, Andrew J., and Miller, Robert F.

Published
2015
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3. Prospective validation of the RAPID clinical risk prediction score in adult patients with pleural infection: the PILOT study

Author

Corcoran, John P., primary, Psallidas, Ioannis, additional, Gerry, Stephen, additional, Piccolo, Francesco, additional, Koegelenberg, Coenraad F., additional, Saba, Tarek, additional, Daneshvar, Cyrus, additional, Fairbairn, Ian, additional, Heinink, Richard, additional, West, Alex, additional, Stanton, Andrew E., additional, Holme, Jayne, additional, Kastelik, Jack A., additional, Steer, Henry, additional, Downer, Nicola J., additional, Haris, Mohammed, additional, Baker, Emma H., additional, Everett, Caroline F., additional, Pepperell, Justin, additional, Bewick, Thomas, additional, Yarmus, Lonny, additional, Maldonado, Fabien, additional, Khan, Burhan, additional, Hart-Thomas, Alan, additional, Hands, Georgina, additional, Warwick, Geoffrey, additional, De Fonseka, Duneesha, additional, Hassan, Maged, additional, Munavvar, Mohammed, additional, Guhan, Anur, additional, Shahidi, Mitra, additional, Pogson, Zara, additional, Dowson, Lee, additional, Popowicz, Natalia D., additional, Saba, Judith, additional, Ward, Neil R., additional, Hallifax, Rob J., additional, Dobson, Melissa, additional, Shaw, Rachel, additional, Hedley, Emma L., additional, Sabia, Assunta, additional, Robinson, Barbara, additional, Collins, Gary S., additional, Davies, Helen E., additional, Yu, Ly-Mee, additional, Miller, Robert F., additional, Maskell, Nick A., additional, and Rahman, Najib M., additional

Published
2020
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10. Self management of patients with mild COPD in primary care: randomised controlled trial

Author

Jolly, Kate, primary, Sidhu, Manbinder S, additional, Hewitt, Catherine A, additional, Coventry, Peter A, additional, Daley, Amanda, additional, Jordan, Rachel, additional, Heneghan, Carl, additional, Singh, Sally, additional, Ives, Natalie, additional, Adab, Peymane, additional, Jowett, Susan, additional, Varghese, Jinu, additional, Nunan, David, additional, Ahmed, Khaled, additional, Dowson, Lee, additional, and Fitzmaurice, David, additional

Published
2018
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11. Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation

Author

Murphy, Patrick B., primary, Rehal, Sunita, additional, Arbane, Gill, additional, Bourke, Stephen, additional, Calverley, Peter M. A., additional, Crook, Angela M., additional, Dowson, Lee, additional, Duffy, Nicholas, additional, Gibson, G. John, additional, Hughes, Philip D., additional, Hurst, John R., additional, Lewis, Keir E., additional, Mukherjee, Rahul, additional, Nickol, Annabel, additional, Oscroft, Nicholas, additional, Patout, Maxime, additional, Pepperell, Justin, additional, Smith, Ian, additional, Stradling, John R., additional, Wedzicha, Jadwiga A., additional, Polkey, Michael I., additional, Elliott, Mark W., additional, and Hart, Nicholas, additional

Published
2017
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12. LATE-BREAKING ABSTRACT: Improving admission free survival with home mechanical ventilation (HMV) and home oxygen therapy (HOT) following life threatening COPD exacerbations: HoT-HMV UK Trial NCT00990132

Author

Murphy, Patrick, primary, Arbane, Gill, additional, Bourke, Stephen, additional, Calverley, Peter, additional, Dowson, Lee, additional, Duffy, Nick, additional, Gibson, G. John, additional, Hughes, Phil, additional, Hurst, John R., additional, Lewis, Keir, additional, Mukherjee, Rahul, additional, Nickol, Annabel, additional, Oscroft, Nicholas, additional, Pepperell, Justin, additional, Rehal, Sunita, additional, Smith, Ian, additional, Stradling, John, additional, Wedizcha, Wisia, additional, Polkey, Michael, additional, Elliott, Mark, additional, and Hart, Nicholas, additional

Published
2016
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13. Patient self-management in primary care patients with mild COPD – protocol of a randomised controlled trial of telephone health coaching

Author

Sidhu, Manbinder S, primary, Daley, Amanda, additional, Jordan, Rachel, additional, Coventry, Peter A, additional, Heneghan, Carl, additional, Jowett, Sue, additional, Singh, Sally, additional, Marsh, Jennifer, additional, Adab, Peymane, additional, Varghese, Jinu, additional, Nunan, David, additional, Blakemore, Amy, additional, Stevens, Jenny, additional, Dowson, Lee, additional, Fitzmaurice, David, additional, and Jolly, Kate, additional

Published
2015
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17. Prevalence and impact of bronchiectasis in alpha1-antitrypsin deficiency.

Author

Parr DG, Guest PG, Reynolds JH, Dowson LJ, Stockley RA, Parr, David G, Guest, Peter G, Reynolds, John H, Dowson, Lee J, and Stockley, Robert A

Abstract

Rationale: alpha(1)-Antitrypsin (AAT) deficiency is associated with increased risk of chronic obstructive pulmonary disease (COPD), in particular emphysema, but airway disease is less well described. Objectives: To assess the prevalence of airways disease in subjects with AAT deficiency and to identify the relationship between radiological airway abnormalities and clinical phenotype. Methods: We characterized the computed tomographic phenotype of 74 subjects (PiZ), using visual scoring of airway disease and densitometric assessment of emphysema. Computed tomographic measurements were related to physiology, health status (St. George's Respiratory Questionnaire), and emphysema severity, and the relative impact of airway disease and emphysema severity on health status and airflow obstruction was compared by stepwise regression. Measurements and Main Results: Bronchiectatic changes were seen in 70 subjects, and a subgroup with a bronchiectasis-predominant phenotype was identified. Clinically significant bronchiectasis (radiologic bronchiectasis in 4 or more bronchopulmonary segments together with symptoms of regular sputum production) occurred in 20 subjects (27%). AAT-deficient index cases had higher airway disease scores (P < 0.05), more severe emphysema (P < 0.001), and greater impairment of physiology (P < 0.001) and health status (P < 0.05) than nonindex cases. Airway disease scores correlated with health status, and bronchial wall thickening correlated with FEV(1). Regression analysis indicated that emphysema severity had the strongest associations for health status (r = 0.505, P < 0.001) and FEV(1) (r = 0.699, P < 0.001), but the addition of airway disease score improved the regression models (r = 0.596, P = 0.002 and r = 0.783, P < 0.001, respectively). Conclusions: Emphysema is the predominant component of COPD in AAT deficiency, but the prevalence and impact of airway disease are greater than currently recognized. Consequently, future therapeutic strategies in AAT deficiency should also target this component of COPD. [ABSTRACT FROM AUTHOR]

Published
2007
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18. The relationship of chronic sputum expectoration to physiologic, radiologic, and health status characteristics in alpha(1)-antitrypsin deficiency (PiZ).

Author

Dowson, Lee J., Guest, Peter J., and Stockley, Robert A.

Subjects
*OBSTRUCTIVE lung diseases, *SPUTUM, *TRYPSIN inhibitors
Abstract

Study Objectives: First, to determine the relationships among chronic sputum expectoration (CSE), exacerbations, airflow obstruction, and emphysema in patients with alpha(1)-antitrypsin deficiency (alpha(1)-ATD) [PiZ]. Second, to use multivariate analysis to determine how these factors influence health status.Design: Cross-sectional, single-center.Setting: UK center for alpha(1)-ATD, university teaching hospital.Patients: One hundred seventeen nonsmoking patients underwent lung function testing, high-resolution CT (HRCT) scanning with density mask analysis, and health status assessment using the St. George's Respiratory Questionnaire (SGRQ) and short form 36 (SF-36) health survey questionnaire.Results: Patients with CSE (n = 50) had worse postbronchodilator airflow obstruction than those who did not (p = 0.03), with a median FEV(1) of 1.15 L (interquartile range [IQR], 0.76 to 1.82) vs 1.44 L (IQR, 0.99 to 2.93), respectively, and higher HRCT scan voxel index (VI) values indicating more extensive emphysema (patients with CSE: median lower zone VI, 50; IQR, 28 to 61; patients without CSE: median lower zone VI, 41; IQR, 5 to 53; p = 0.04). Patients with CSE also had worse health status, as assessed by the SGRQ (p < 0.01 for all domains) and SF-36 questionnaire (p < 0.05 for seven of nine domains). Exacerbation frequency was greater in those patients with CSE (p < 0.001), with a median of two episodes per year (IQR, 1 to 3) vs 0.66 episodes per year (IQR, 0 to 2) for those without CSE. Stepwise linear regression analysis revealed FEV(1), exacerbation frequency, and lower zone VI to be the most important predictors of health status.Conclusions: Among patients with alpha(1)-ATD, those with CSE expectoration exhibit greater physiologic impairment and more extensive emphysema than those without. This is reflected in an inferior health status, which is also influenced independently by an increased exacerbation frequency in those with CSE. [ABSTRACT FROM AUTHOR]

Published
2002
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19. Children must be protected from the tobacco industry's marketing tactics

Author

Hopkinson, Nicholas, Wallis, Colin, Higgins, Bernard, Gaduzo, Stephen, Sherrington, Rebecca, Keilty, Sarah, Stern, Myra, Britton, John, Bush, Andrew, Moxham, John, Sylvester, Karl, Griffiths, Valerie, Sutherland, Tim, Crossingham, Iain, Raju, Raghu, Spencer, Charlotte, Safavi, Shahideh, Deegan, Paul, Seymour, John, Hickman, Katherine, Hughes, John, Wieboldt, Jason, Shaheen, Fizah, Peedell, Clive, Mackenzie, Nesta, Nicholl, David, Jolley, Caroline, Crooks, Gillian, Dow, Claire, Deveson, Pete, Bintcliffe, Oliver, Gray, Barry, Kumar, Sanjay, Haney, Sarah, Docherty, Marianne, Thomas, Angela, Chua, Felix, Dwarakanath, Akshay, Summers, Geoffrey, Prowse, Keith, Lytton, Stephen, Ong, Yee Ean, Graves, Jennifer, Banerjee, Tushar, English, Peter, Leonard, Andrew, Brunet, Martin, Chaudhry, Nauman, Ketchell, Robert Ian, Cummings, Natalie, Lebus, Jenny, Sharp, Charles, Meadows, Chris, Harle, Amelie, Stewart, Tara, Parry, Diane, Templeton-Wright, Suzanne, Moore-Gillon, John, Stratford- Martin, James, Saini, Sarvesh, Matusiewicz, Simon, Merritt, Simon, Dowson, Lee, Satkunam, Karnan, Hodgson, Luke, Suh, Eui-Sik, Durrington, Hannah, Browne, Emma, Walters, Nicola, Steier, Joerg, Barry, Simon, Griffiths, Mark, Hart, Nicholas, Nikolic, Marko, Berry, Matthew, Thomas, Ajit, Miller, Joy, McNicholl, Diarmuid, Marsden, Paul, Warwick, Geoffrey, Barr, Laura, Adeboyeku, David, Mohd Noh, Mohd Shahrin, Griffiths, Paul, Davies, Lisa, Quint, Jennifer, Lyall, Rebecca, Shribman, Jonathan, Collins, Andrea, Goldman, Jon, Bloch, Susannah, Gill, Alison, Man, William, Christopher, Anne, Yasso, Razouqi, Rajhan, Ashwin, Shrikrishna, Dinesh, Moore, Caroline, Absalom, Gareth, Booton, Richard, Fowler, Robert William, Mackinlay, Carolyn, Sapey, Elizabeth, Lock, Sara, Walker, Paul, Jha, Akhilesh, Satia, Imran, Bradley, Bethia, Mustfa, Naveed, Haqqee, Raana, Thomas, Matt, Patel, Anant, Redington, Anthony, Pillai, Anilkumar, Keaney, Niall, Fowler, Stephen, Lowe, Lesley, Brennan, Amanda, Morrison, Douglas, Murray, Clare, Hankinson, Jenny, Dutta, P, Maddocks, Matthew, Pengo, Martino, Curtis, Katrina, Rafferty, Gerrard, Hutchinson, John, Whitfield, Ruth, Turner, Steve, Breen, Ronan, Naveed, Shams-un-nisa, Goode, Chris, Esterbrook, Georgina, Ahmed, Liju, Walker, Woolf, Ford, David, Connett, Gary, Davidson, Philip, Elston, Will, Stanton, Andrew, Morgan, David, Myerson, James, Maxwell, David, Harrris, Ann, Parmar, Sonia, Houghton, Catherine, Winter, Robert, Puthucheary, Zudin, Thomson, Fiona, Sturney, Sharon, Harvey, John, Haslam, Patricia L, Patel, Irem, Jennings, David, Range, Simon, Mallia-Milanes, Brendan, Collett, Anne, Tate, Paul, Russell, Richard, Feary, Johanna, O'Driscoll, Ronan, Eaden, James, Round, Jonathan, Sharkey, Emma, Montgomery, Mary, Vaughan, Sophie, Scheele, Kate, Lithgow, Anna, Partridge, Samuel, Chavasse, Richard, Restrick, Louise, Agrawal, Sanjay, Abdallah, Said, Lacy-Colson, Amruta, Adams, Nick, Mitchell, Sally, Haja Mydin, Helmy, Ward, Ann, Denniston, Sarah, Steel, Mark, Ghosh, Dipansu, Connellan, Stephen, Rigge, Lucy, Williams, Ruth, Grove, Alison, Anwar, Sadia, Dobson, Lee, Hosker, Harold, Stableforth, David, Greening, Neil, Howell, Tim, Casswell, Georgina, Davies, Sarah, Tunnicliffe, Georgia, Mitchelmore, Philip, Phitidis, Elpida, Robinson, Louise, Bafadhel, Mona, Robinson, Grace, Boland, Alison, Lipman, Marc, Bourke, Stephen, Kaul, Sundeep, Cowie, Calvin, Forrest, Ian, Starren, Elizabeth, Burke, Hannah, Furness, John, Bhowmik, Angshu, Everett, Caroline, Seaton, Douglas, Holmes, Steve, Doe, Simon, Parker, Samuel, Graham, Annika, Paterson, Ian, Maqsood, Usman, Ohri, Chandra, Iles, Peter, Kemp, Samuel, Iftikhar, Ahsan, Carlin, Chris, Fletcher, Tim, Emerson, Peter, Beasley, Victoria, Ramsay, Michelle, Buttery, Robert, Mungall, Sarah, Crooks, Stephen, Ridyard, John, Ross, David, Guadagno, Alison, Holden, Emma, Coutts, Ian, Cullen, Kathy, O'Connor, Sally, Barker, Jack, Sloper, Katherine, Watson, John, Smith, Peter, Anderson, Paul, Brown, Louise, Nyman, Cyril, Milburn, Heather, Clive, Amelia, Serlin, Matthew, Bolton, Charlotte, Fuld, Jonathan, Powell, Helen, Dayer, Mark, Woolhouse, Ian, Georgiadi, Adamantia, Leonard, Helen, Dodd, James, Campbell, Ian, Ruiz, Gary, Zurek, Andrew, Paton, James Y, Malin, Adam, Wood, Fraser, Hynes, Gareth, Connell, David, Spencer, David, Brown, Sarah, Smith, David, Cooper, David, O'Kane, Cecilia, Hicks, Alex, Creagh-Brown, Ben, Lordan, James, Nickol, Annabel, Primhak, Robert, Fleming, Louise, Powrie, Duncan, Brown, Joanna, Zoumot, Zaid, Elkin, Sarah, Szram, Joanna, Scaffardi, Anthony, Marshall, Robert, Macdonald, Ian, Lightbody, Darren, Farmer, Ray, Wheatley, Iain, Radnan, Paul, Lane, Ian, Booth, Andrew, Tilbrook, Sean, Capstick, Toby, Hewitt, Lee, McHugh, Martin, Nelson, Christopher, Wilson, Patrick, Padmanaban, Vijay, White, John, Davison, John, O'Callaghan, Una, Hodson, Matthew, Edwards, John, Campbell, Colin, Ward, Simon, Wooler, Edwina, Ringrose, Elizabeth, Bridges, Diana, Matthew Hodson, John Edwards, Colin Campbell, Simon Ward, Edwina Wooler, Elizabeth Ringrose, Diana Bridges, Rosalind Backham, Kim Randall, Tracey Mathieson, Long, Alex, Parkes, Marilyn, Clarke, Sarah, Allen, Bev, Connelly, Carol, Forster, Georgia, Hoadley, Jacky, Martin, Katharine, Barnham, Kate, Khan, Katie, Munday, Maureen, Edwards, Catherine, O'Hara, Doreen, Turner, Sally, Pieri-Davies, Sue, Ford, Kate, Daniels, Tracey, Wright, Joanne, Towns, Rebecca, Fern, Karen, Butcher, Jane, Burgin, Karen, Winter, Barbara, Freeman, Debbie, Olive, Sandra, Gray, Linda, Pye, Kathy, Roots, Debbie, Cox, Nicola, Davies, Carol-Anne, Wicker, Jacquelyne, Hilton, Kay, Lloyd, Jananee, MacBean, Vicky, Wood, Marion, Kowal, Julia, Downs, Janis, Ryan, Helen, Guyatt, Fran, Nicoll, Debby, Lyons, Elizabeth, Narasimhan, Divya, Rodman, Anne, Walmsley, Sandy, Newey, Alison, Buxton, Maria, Dewar, Maria, Cooper, Angela, Reilly, Jacqui, Lloyd, Julie, Macmillan, Alison Bennett, Olley, Amy, Voase, Nia, Martin, Sarah, McCarvill, Iona, Christensen, Anne, Agate, Rowan, Heslop, Karen, Timlett, Amber, Hailes, Karen, Davey, Claire, Pawulska, Barbara, Lane, Amber, Ioakim, Shona, Hough, Alexandra, Treharne, Jo, Jones, Helen, Winter-Burke, Alice, Miller, Lauren, Connolly, Bronwen, Bingham, Lyn, Fraser, Una, Bott, Julia, Johnston, Carol, Graham, Alison, Curry, Denise, Sumner, Helen, Costello, Carol Ann, Bartoszewicz, Charlotte, Badman, Ros, Williamson, Kathryn, Taylor, Amy, Purcell, Helen, Barnett, Emma, Molloy, Alanna, Crawfurd, Laura, Collins, Nicola, Monaghan, Valerie, Mir, Misbah, Lord, Victoria, Stocks, Janet, Edwards, Adrian, Greenhalgh, Trish, Lenney, Warren, McKee, Martin, McAuley, Danny, Majeed, Azeem, Cookson, John, Baker, Emma, Janes, Sam, Wedzicha, Wisia, Lomas Dean, David, Harrison, Brian, Davison, Tony, Calverley, Peter, Wilson, Robert, Stockley, Robert, Ayres, Jon, Gibson, John, Simpson, John, Burge, Sherwood, Warner, John, Thomson, Neil, Davies, Peter, Woodcock, Ashley, Woodhead, Mark, Spiro, Stephen, Ormerod, Lawrence, Bothamley, Graham, Partridge, Martyn, Shields, Michael, Montgomery, Hugh, Simonds, Anita, Barnes, Peter, Durham, Stephen, Malone, Sarah, Arabnia, Gilda, Olivier, Sharon, Gardiner, Karen, and Edwards, Sheila

Subjects
Marketing, Tobacco harm reduction, Government, Adolescent, Health professionals, business.industry, MEDLINE, Tobacco Industry, Tobacco Products, General Medicine, Tobacco industry, United Kingdom, Lung disease, Environmental health, Tobacco in Alabama, Product Packaging, Humans, Medicine, Packaging and labeling, Child, business
Abstract

Every day in the UK, hundreds of children aged 11-15 years start smoking for the first time,1 2 and there is compelling evidence that children’s perceptions of cigarettes are influenced by branding.3 4 As health professionals working to prevent and treat lung disease caused by smoking, we welcome the government’s …

20. Si ion implantation into LEC semi-insulating GaAs

Author

Yan Shulan, Zhou Shuxing, and Dowson Lee

Subjects
Charge-carrier density, Ion implantation, Materials science, Hall effect, Annealing (metallurgy), Analytical chemistry, MESFET, Condensed Matter Physics, Instrumentation, Semi insulating, Lower energy, Surfaces, Coatings and Films
Abstract

The implantations were performed at room temperature on LEC semi-insulating GaAs substrates to form n-type layers at energies of 80–130 keV with doses of 3–8 × 10 12 cm −2 and an n + layer at lower energy of 40 keV with a higher dose of 1 × 10 14 cm −2 . I—V characteristic, capacity-voltage profiling, and Hall effect measurements were used to investigate the electrical properties of the implanted layers after annealing. The carrier mobilities and electrical activities measured in the n-type layers are 2500–3000 cm 2 V −1 and 55–88%, respectively, and the maximum carrier density of the n + /n structure, which is used to fabricate GaAs MESFET's and DIC's, is as high as 2 × 10 18 cm −3 and is desirable to decrease the resistances of source and drain contacts. Damage removal and carrier activation in the annealed implanted regions are discussed and device application results are presented in this paper.

Published
1989

22. Children must be protected from the tobacco industry's marketing tactics.

Author

Hopkinson N, Wallis C, Higgins B, Gaduzo S, Sherrington R, Keilty S, Stern M, Britton J, Bush A, Moxham J, Sylvester K, Griffiths V, Sutherland T, Crossingham I, Raju R, Spencer C, Safavi S, Deegan P, Seymour J, Hickman K, Hughes J, Wieboldt J, Shaheen F, Peedell C, Mackenzie N, Nicholl D, Jolley C, Crooks G, Crooks G, Dow C, Deveson P, Bintcliffe O, Gray B, Kumar S, Haney S, Docherty M, Thomas A, Chua F, Dwarakanath A, Summers G, Prowse K, Lytton S, Ong YE, Graves J, Banerjee T, English P, Leonard A, Brunet M, Chaudhry N, Ketchell RI, Cummings N, Lebus J, Sharp C, Meadows C, Harle A, Stewart T, Parry D, Templeton-Wright S, Moore-Gillon J, Stratford- Martin J, Saini S, Matusiewicz S, Merritt S, Dowson L, Satkunam K, Hodgson L, Suh ES, Durrington H, Browne E, Walters N, Steier J, Barry S, Griffiths M, Hart N, Nikolic M, Berry M, Thomas A, Miller J, McNicholl D, Marsden P, Warwick G, Barr L, Adeboyeku D, Mohd Noh MS, Griffiths P, Davies L, Quint J, Lyall R, Shribman J, Collins A, Goldman J, Bloch S, Gill A, Man W, Christopher A, Yasso R, Rajhan A, Shrikrishna D, Moore C, Absalom G, Booton R, Fowler RW, Mackinlay C, Sapey E, Lock S, Walker P, Jha A, Satia I, Bradley B, Mustfa N, Haqqee R, Thomas M, Patel A, Redington A, Pillai A, Keaney N, Fowler S, Lowe L, Brennan A, Morrison D, Murray C, Hankinson J, Dutta P, Maddocks M, Pengo M, Curtis K, Rafferty G, Hutchinson J, Whitfield R, Turner S, Breen R, Naveed SU, Goode C, Esterbrook G, Ahmed L, Walker W, Ford D, Connett G, Davidson P, Elston W, Stanton A, Morgan D, Myerson J, Maxwell D, Harrris A, Parmar S, Houghton C, Winter R, Puthucheary Z, Thomson F, Sturney S, Harvey J, Haslam PL, Patel I, Jennings D, Range S, Mallia-Milanes B, Collett A, Tate P, Russell R, Feary J, O'Driscoll R, Eaden J, Round J, Sharkey E, Montgomery M, Vaughan S, Scheele K, Lithgow A, Partridge S, Chavasse R, Restrick L, Agrawal S, Abdallah S, Lacy-Colson A, Adams N, Mitchell S, Haja Mydin H, Ward A, Denniston S, Steel M, Ghosh D, Connellan S, Rigge L, Williams R, Grove A, Anwar S, Dobson L, Hosker H, Stableforth D, Greening N, Howell T, Casswell G, Davies S, Tunnicliffe G, Mitchelmore P, Phitidis E, Robinson L, Prowse K, Bafadhel M, Robinson G, Boland A, Lipman M, Bourke S, Kaul S, Cowie C, Forrest I, Starren E, Burke H, Furness J, Bhowmik A, Everett C, Seaton D, Holmes S, Doe S, Parker S, Graham A, Paterson I, Maqsood U, Ohri C, Iles P, Kemp S, Iftikhar A, Carlin C, Fletcher T, Emerson P, Beasley V, Ramsay M, Buttery R, Mungall S, Crooks S, Ridyard J, Ross D, Guadagno A, Holden E, Coutts I, Cullen K, O'Connor S, Barker J, Sloper K, Watson J, Smith P, Anderson P, Brown L, Nyman C, Milburn H, Clive A, Serlin M, Bolton C, Fuld J, Powell H, Dayer M, Woolhouse I, Georgiadi A, Leonard H, Dodd J, Campbell I, Ruiz G, Zurek A, Paton JY, Malin A, Wood F, Hynes G, Connell D, Spencer D, Brown S, Smith D, Cooper D, O'Kane C, Hicks A, Creagh-Brown B, Lordan J, Nickol A, Primhak R, Fleming L, Powrie D, Brown J, Zoumot Z, Elkin S, Szram J, Scaffardi A, Marshall R, Macdonald I, Lightbody D, Farmer R, Wheatley I, Radnan P, Lane I, Booth A, Tilbrook S, Capstick T, Hewitt L, McHugh M, Nelson C, Wilson P, Padmanaban V, White J, Davison J, O'Callaghan U, Hodson M, Edwards J, Campbell C, Ward S, Wooler E, Ringrose E, Bridges D, Matthew Hodson, John Edwards, Colin Campbell, Simon Ward, Edwina Wooler, Elizabeth Ringrose, Diana Bridges, Rosalind Backham, Kim Randall, Tracey Mathieson, Long A, Parkes M, Clarke S, Allen B, Connelly C, Forster G, Hoadley J, Martin K, Barnham K, Khan K, Munday M, Edwards C, O'Hara D, Turner S, Pieri-Davies S, Ford K, Daniels T, Wright J, Towns R, Fern K, Butcher J, Burgin K, Winter B, Freeman D, Olive S, Gray L, Pye K, Roots D, Cox N, Davies CA, Wicker J, Hilton K, Lloyd J, MacBean V, Wood M, Kowal J, Downs J, Ryan H, Guyatt F, Nicoll D, Lyons E, Narasimhan D, Rodman A, Walmsley S, Newey A, Buxton M, Dewar M, Cooper A, Reilly J, Lloyd J, Macmillan AB, Roots D, Olley A, Voase N, Martin S, McCarvill I, Christensen A, Agate R, Heslop K, Timlett A, Hailes K, Davey C, Pawulska B, Lane A, Ioakim S, Hough A, Treharne J, Jones H, Winter-Burke A, Miller L, Connolly B, Bingham L, Fraser U, Bott J, Johnston C, Graham A, Curry D, Sumner H, Costello CA, Bartoszewicz C, Badman R, Williamson K, Taylor A, Purcell H, Barnett E, Molloy A, Crawfurd L, Collins N, Monaghan V, Mir M, Lord V, Stocks J, Edwards A, Greenhalgh T, Lenney W, McKee M, McAuley D, Majeed A, Cookson J, Baker E, Janes S, Wedzicha W, Lomas Dean D, Harrison B, Davison T, Calverley P, Wilson R, Stockley R, Ayres J, Gibson J, Simpson J, Burge S, Warner J, Lenney W, Thomson N, Davies P, Woodcock A, Woodhead M, Spiro S, Ormerod L, Bothamley G, Partridge M, Shields M, Montgomery H, Simonds A, Barnes P, Durham S, Malone S, Arabnia G, Olivier S, Gardiner K, and Edwards S

Subjects
Adolescent, Child, Humans, Marketing standards, Product Packaging standards, Tobacco Industry standards, United Kingdom, Marketing legislation & jurisprudence, Product Packaging legislation & jurisprudence, Tobacco Industry legislation & jurisprudence, Tobacco Products
Published
2013
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23. The effect of augmentation therapy on bronchial inflammation in alpha1-antitrypsin deficiency.

Author

Stockley RA, Bayley DL, Unsal I, and Dowson LJ

Subjects
Biomarkers analysis, Bronchitis blood, Dose-Response Relationship, Drug, Drug Administration Schedule, Enzyme-Linked Immunosorbent Assay, Female, Humans, Infusions, Intravenous, Interleukin-8 analysis, Leukotriene B4 analysis, Male, Pancreatic Elastase analysis, Peroxidase analysis, Prognosis, Reference Values, Sensitivity and Specificity, Sputum chemistry, Sputum cytology, Sputum microbiology, Treatment Outcome, alpha 1-Antitrypsin analysis, Bronchitis drug therapy, Bronchitis etiology, alpha 1-Antitrypsin administration & dosage, alpha 1-Antitrypsin Deficiency complications, alpha 1-Antitrypsin Deficiency drug therapy
Abstract

alpha1-Antitrypsin (AAT) deficiency predisposes to bronchitis and emphysema associated with neutrophilic airway inflammation. The efficacy of augmentation therapy has not been proven clinically or by demonstrating an effect on airway inflammation. We treated 12 patients with four infusions of Prolastin (60 mg/kg) at weekly intervals and monitored both the serum and secretion concentrations of AAT as well as markers of neutrophilic inflammation, including myeloperoxidase, elastase, and the neutrophil chemoattractants interleukin-8 and leukotriene B(4). Serum AAT rose and was maintained above the protective threshold. In addition, AAT concentrations in the sputum rose from a mean of 0.17 microM (SEM +/- 0.04) before therapy to concentrations similar to nondeficient subjects (0.43 +/- 0.12) 1 week after the first infusion (p < 0.01). This was associated with a reduction in elastase activity (p < 0.002) and the chemoattractant leukotriene B(4) (p < 0.02), which fell from a median baseline value of 13.46 nM (range, 4.17-55.00) to 8.62 nM (4.23-21.59) the day following the last infusion. Although median values for myeloperoxidase and interleukin-8 also fell, the changes failed to achieve statistical significance. In summary, short-term therapy with AAT increased lung secretion concentrations and was associated with a fall in leukotriene B(4), which is thought to be central to the airway inflammation of AAT deficiency.

Published
2002
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