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3. Peer support for people living with hepatitis B virus—A foundation for treatment expansion

Author

Downs, Louise O., primary, Kabagambe, Kenneth, additional, Williams, Sarah, additional, Waddilove, Elizabeth, additional, Delphin, Marion, additional, Lumley, Sheila F., additional, Ndungutse, Richard, additional, Kimono, Beatrice, additional, Newton, Robert, additional, Ko, Joy, additional, Martyn, Emily, additional, Carter, Jessica, additional, Kemper, Agnieszka, additional, Monteiro, Fernando, additional, O'Regan, Sive, additional, Surey, Julian, additional, Sultan, Binta, additional, Story, Alistair, additional, MacDonald, Douglas, additional, Tu, Thomas, additional, Seeley, Janet, additional, Dusheiko, Geoffrey, additional, Maponga, Tongai, additional, Andersson, Monique I., additional, Spearman, C. Wendy, additional, Tucker, Joseph D., additional, Cohen, Chari, additional, Wang, Su, additional, Adda, Danjuma, additional, Freeland, Catherine, additional, Halford, Rachel, additional, Jack, Kathryn, additional, Ghosh, Indrajit, additional, Elsharkawy, Ahmed M., additional, Matthews, Philippa C., additional, and Flanagan, Stuart, additional

Published
2024
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5. Nanopore metagenomic sequencing to investigate nosocomial transmission of human metapneumovirus from a unique genetic group among haematology patients in the United Kingdom

Author

Xu, Yifei, Lewandowski, Kuiama, Jeffery, Katie, Downs, Louise O., Foster, Dona, Sanderson, Nicholas D., Kavanagh, James, Vaughan, Ali, Salvagno, Claudia, Vipond, Richard, Carroll, Miles, Danby, Robert, Peto, Timothy, Crook, Derrick, Walker, A. Sarah, Matthews, Philippa C., and Pullan, Steven T.

Published
2020
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6. Corrigendum to A systematic review and meta-analysis of the risk of hepatitis B virus (HBV) resistance in people treated with entecavir or tenofovir.: Journal of Clinical Virology 174 (2024) 105711

Author

Lumley, Sheila F., Delphin, Marion, Mokaya, Jolynne, Tan, Cedric C.S., Martyn, Emily, Anderson, Motswedi, Li, Ka Chun, Waddilove, Elizabeth, Sukali, Gloria, Downs, Louise O., Said, Khadija, Okanda, Dorcas, Campbell, Cori, Harriss, Eli, Shimakawa, Yusuke, and Matthews, Philippa C.

Published
2024
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7. Where do those data go? Reuse of screening results from clinical trials to estimate population prevalence of HBV infection in adults in Kilifi, Kenya

Author

Downs, Louise O., primary, Campbell, Cori, additional, Abouyannis, Michael, additional, Otiende, Mark, additional, Kapulu, Melissa, additional, Obiero, Christina W., additional, Hamaluba, Mainga, additional, Ngetsa, Caroline, additional, Andersson, Monique I., additional, Githinji, George, additional, Warimwe, George, additional, Baisley, Kathy, additional, Scott, J. Anthony G., additional, Matthews, Philippa C., additional, and Etyang, Anthony, additional

Published
2023
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8. A systematic review and meta-analysis of the risk of hepatitis B virus (HBV) genotypic resistance in people treated with entecavir or tenofovir

Author

Lumley, Sheila F, primary, Delphin, Marion, additional, Mokaya, Jolynne F, additional, Tan, Cedric CS, additional, Martyn, Emily, additional, Anderson, Motswedi, additional, Li, Ka Chun, additional, Waddilove, Elizabeth, additional, Sukali, Gloria, additional, Downs, Louise O, additional, Said, Kadija, additional, Okanda, Dorcas, additional, Campbell, Cori, additional, Harriss, Eli, additional, Shimakawa, Yusuke, additional, and Matthews, Philippa C, additional

Published
2023
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10. Pan-genotypic probe-based enrichment to improve efficiency of Hepatitis B virus sequencing

Author

Lumley, Sheila F, primary, Jennings, Daisy, additional, Waddilove, Elizabeth, additional, Trebes, Amy, additional, Delphin, Marion, additional, Downs, Louise O, additional, MacIntyre-Cockett, George, additional, Wu, Yanxia, additional, Chaudron, Sandra, additional, de Lara, Catherine, additional, Chai, Haiting, additional, Maponga, Tongai G, additional, Martin, Jacqueline, additional, Collier, Jane, additional, Ip, Camilla LC, additional, Barnes, Eleanor, additional, Bonsall, David, additional, Piazza, Paolo, additional, Ansari, M. Azim, additional, and Matthews, Philippa C, additional

Published
2023
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14. Nanopore metagenomic sequencing of influenza virus directly from respiratory samples: diagnosis, drug resistance and nosocomial transmission, United Kingdom, 2018/19 influenza season

Author

Xu, Yifei, primary, Lewandowski, Kuiama, additional, Downs, Louise O, additional, Kavanagh, James, additional, Hender, Thomas, additional, Lumley, Sheila, additional, Jeffery, Katie, additional, Foster, Dona, additional, Sanderson, Nicholas D, additional, Vaughan, Ali, additional, Morgan, Marcus, additional, Vipond, Richard, additional, Carroll, Miles, additional, Peto, Timothy, additional, Crook, Derrick, additional, Walker, A Sarah, additional, Matthews, Philippa C, additional, and Pullan, Steven T, additional

Published
2021
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15. Differential occupational risks to healthcare workers from SARS-CoV-2: A prospective observational study

Author

Eyre, David W, Lumley, Sheila F, O’Donnell, Denise, Campbell, Mark, Sims, Elizabeth, Lawson, Elaine, Warren, Fiona, James, Tim, Cox, Stuart, Howarth, Alison, Doherty, George, Hatch, Stephanie B, Kavanagh, James, Chau, Kevin K, Fowler, Philip W, Swann, Jeremy, Volk, Denis, Yang-Turner, Fan, Stoesser, Nicole E, Matthews, Philippa C, Dudareva, Maria, Davies, Timothy, Shaw, Robert H, Peto, Leon, Downs, Louise O, Vogt, Alexander, Amini, Ali, Young, Bernadette C, Drennan, Philip, Mentzer, Alexander J, Skelly, Donal, Karpe, Fredrik, Neville, Matt J, Andersson, Monique, Brent, Andrew J, Jones, Nicola, Ferreira, Lucas Martins, Christott, Thomas, Marsden, Brian D, Hoosdally, Sarah, Cornall, Richard, Crook, Derrick W, Stuart, David, Screaton, Gavin, Peto, Timothy EA, Holthof, Bruno, O’Donnell, Anne-Marie, Ebner, Daniel, Conlon, Christopher P, Jeffery, Katie, and Walker, Timothy M

Subjects
medicine.medical_specialty, business.industry, Psychological intervention, Odds ratio, Logistic regression, Intensive care unit, law.invention, law, Emergency medicine, Health care, Medicine, Observational study, business, Personal protective equipment, Contact tracing
Abstract

BackgroundPersonal protective equipment (PPE) and social distancing are designed to mitigate risk of occupational SARS-CoV-2 infection in hospitals. Why healthcare workers nevertheless remain at increased risk is uncertain.MethodsWe conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using nasopharyngeal PCR testing and immunoassays for IgG antibodies. A positive result by either modality determined a composite outcome. Risk-factors for Covid-19 were investigated using multivariable logistic regression.Results1083/9809(11.0%) staff had evidence of Covid-19 at some time and provided data on potential risk-factors. Staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.63 [95%CI 3.30-6.50]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (21.2% vs. 8.2% elsewhere) (aOR 2.49 [2.00-3.12]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.50 [1.05-2.15]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit (ICU) staff were relatively protected (0.46 [0.29-0.72]). Positive results were more likely in Black (1.61 [1.20-2.16]) and Asian (1.58 [1.34-1.86]) staff, independent of role or working location, and in porters and cleaners (1.93 [1.25-2.97]). Contact tracing around asymptomatic staff did not lead to enhanced case identification. 24% of staff/patients remained PCR-positive at ≥6 weeks post-diagnosis.ConclusionsIncreased Covid-19 risk was seen in acute medicine, among Black and Asian staff, and porters and cleaners. A bundle of PPE-related interventions protected staff in ICU.

Published
2020
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17. SARS-CoV-2 antibody prevalence, titres and neutralising activity in an antenatal cohort, United Kingdom, 14 April to 15 June 2020

Author

Lumley, Sheila F, primary, Eyre, David W, additional, McNaughton, Anna L, additional, Howarth, Alison, additional, Hoosdally, Sarah, additional, Hatch, Stephanie B, additional, Kavanagh, James, additional, Chau, Kevin K, additional, Downs, Louise O, additional, Cox, Stuart, additional, Dunn, Laura, additional, Justice, Anita, additional, Wareing, Susan, additional, Dingle, Kate, additional, Rudkin, Justine, additional, Auckland, Kathryn, additional, Fyfe, Alexander, additional, Bolton, Jai, additional, Paton, Robert, additional, Mentzer, Alexander J, additional, Jeffery, Katie, additional, Andersson, Monique I, additional, James, Tim, additional, Peto, Tim E A, additional, Marsden, Brian D, additional, Screaton, Gavin, additional, Cornall, Richard J, additional, Klenerman, Paul, additional, Ebner, Daniel, additional, Stuart, David I, additional, Crook, Derrick W, additional, Stoesser, Nicole, additional, Kennedy, Stephen H, additional, Thompson, Craig, additional, Gupta, Sunetra, additional, and Matthews, Philippa C, additional

Published
2020
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19. Bimodal distribution and set point HBV DNA viral loads in chronic infection: retrospective analysis of cohorts from the UK and South Africa

Author

Downs, Louise O., primary, Vawda, Sabeehah, additional, Bester, Phillip Armand, additional, Lythgoe, Katrina A., additional, Wang, Tingyan, additional, McNaughton, Anna L., additional, Smith, David A., additional, Maponga, Tongai, additional, Freeman, Oliver, additional, Várnai, Kinga A., additional, Davies, Jim, additional, Woods, Kerrie, additional, Fraser, Christophe, additional, Barnes, Eleanor, additional, Goedhals, Dominique, additional, and Matthews, Philippa C., additional

Published
2020
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20. SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus

Author

Andersson, Monique I., primary, Arancibia-Carcamo, Carolina V., additional, Auckland, Kathryn, additional, Baillie, J. Kenneth, additional, Barnes, Eleanor, additional, Beneke, Tom, additional, Bibi, Sagida, additional, Brooks, Tim, additional, Carroll, Miles, additional, Crook, Derrick, additional, Dingle, Kate, additional, Dold, Christina, additional, Downs, Louise O., additional, Dunn, Laura, additional, Eyre, David W., additional, Gilbert Jaramillo, Javier, additional, Harvala, Heli, additional, Hoosdally, Sarah, additional, Ijaz, Samreen, additional, James, Tim, additional, James, William, additional, Jeffery, Katie, additional, Justice, Anita, additional, Klenerman, Paul, additional, Knight, Julian C., additional, Knight, Michael, additional, Liu, Xu, additional, Lumley, Sheila F., additional, Matthews, Philippa C., additional, McNaughton, Anna L., additional, Mentzer, Alexander J., additional, Mongkolsapaya, Juthathip, additional, Oakley, Sarah, additional, Oliveira, Marta S., additional, Peto, Timothy, additional, Ploeg, Rutger J., additional, Ratcliff, Jeremy, additional, Robbins, Melanie J., additional, Roberts, David J., additional, Rudkin, Justine, additional, Russell, Rebecca A., additional, Screaton, Gavin, additional, Semple, Malcolm G., additional, Skelly, Donal, additional, Simmonds, Peter, additional, Stoesser, Nicole, additional, Turtle, Lance, additional, Wareing, Susan, additional, and Zambon, Maria, additional

Published
2020
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21. SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus

Author

Andersson, Monique I, primary, Arancibia-Cárcamo, Carolina V, additional, Auckland, Kathryn, additional, Baillie, J Kenneth, additional, Barnes, Eleanor, additional, Beneke, Tom, additional, Bibi, Sagida, additional, Carroll, Miles, additional, Crook, Derrick, additional, Dingle, Kate, additional, Dold, Christina, additional, Downs, Louise O, additional, Dunn, Laura, additional, Eyre, David W, additional, Jaramillo, Javier Gilbert, additional, Harvala, Heli, additional, Hoosdally, Sarah, additional, Ijaz, Samreen, additional, James, Tim, additional, James, William, additional, Jeffery, Katie, additional, Justice, Anita, additional, Klenerman, Paul, additional, Knight, Julian, additional, Knight, Michael, additional, Liu, Xu, additional, Lumley, Sheila F, additional, Matthews, Philippa C, additional, McNaughton, Anna L, additional, Mentzer, Alexander J, additional, Mongkolsapaya, Juthathip, additional, Oakley, Sarah, additional, Oliveira, Marta S, additional, Peto, Timothy, additional, Ploeg, Rutger J, additional, Ratcliff, Jeremy, additional, Roberts, David J, additional, Rudkin, Justine, additional, Russell, Rebecca A, additional, Screaton, Gavin, additional, Semple, Malcolm G, additional, Skelly, Donal, additional, Simmonds, Peter, additional, Stoesser, Nicole, additional, Turtle, Lance, additional, Wareing, Sue, additional, and Zambon, Maria, additional

Published
2020
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22. Nanopore metagenomic sequencing of influenza virus directly from respiratory samples: diagnosis, drug resistance and nosocomial transmission

Author

Xu, Yifei, primary, Lewandowski, Kuiama, additional, Downs, Louise O, additional, Kavanagh, James, additional, Hender, Thomas, additional, Lumley, Sheila, additional, Jeffery, Katie, additional, Foster, Dona, additional, Sanderson, Nicholas D, additional, Vaughan, Ali, additional, Morgan, Marcus, additional, Vipond, Richard, additional, Carroll, Miles, additional, Peto, Timothy, additional, Crook, Derrick, additional, Walker, A Sarah, additional, Matthews, Philippa C, additional, and Pullan, Steven T, additional

Published
2020
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23. Liver function tests and fibrosis scores in a rural population in Africa: a cross-sectional study to estimate the burden of disease and associated risk factors

Author

O'Hara, Geraldine, primary, Mokaya, Jolynne, additional, Hau, Jeffrey P, additional, Downs, Louise O, additional, McNaughton, Anna L, additional, Karabarinde, Alex, additional, Asiki, Gershim, additional, Seeley, Janet, additional, Matthews, Philippa C, additional, and Newton, Robert, additional

Published
2020
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24. Bimodal distribution and set point HBV DNA viral loads in chronic infection: retrospective analysis of cohorts from the UK and South Africa

Author

Downs, Louise O, primary, Vawda, Sabeehah, additional, Bester, Phillip Armand, additional, Lythgoe, Katrina A, additional, Wang, Tingyan, additional, McNaughton, Anna L, additional, Smith, David A, additional, Maponga, Tongai, additional, Freeman, Oliver, additional, Várnai, Kinga A, additional, Davies, Jim, additional, Woods, Kerrie, additional, Fraser, Christophe, additional, Barnes, Eleanor, additional, Goedhals, Dominique, additional, and Matthews, Philippa C, additional

Published
2020
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25. Nanopore metagenomic sequencing of influenza virus directly from respiratory samples: diagnosis, drug resistance and nosocomial transmission, United Kingdom, 2018/19 influenza season.

Author

Yifei Xu, Lewandowski, Kuiama, Downs, Louise O., Kavanagh, James, Hender, Thomas, Lumley, Sheila, Jeffery, Katie, Foster, Dona, Sanderson, Nicholas D., Vaughan, Ali, Morgan, Marcus, Vipond, Richard, Carroll, Miles, Peto, Timothy, Crook, Derrick, Walker, A Sarah, Matthews, Philippa C., and Pullan, Steven T.

Published
2021
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27. Electronic Health Informatics Data To Describe Clearance Dynamics of Hepatitis B Surface Antigen (HBsAg) and e Antigen (HBeAg) in Chronic Hepatitis B Virus Infection

Author

Downs, Louise O., primary, Smith, David A., additional, Lumley, Sheila F., additional, Patel, Meha, additional, McNaughton, Anna L., additional, Mokaya, Jolynne, additional, Ansari, M. Azim, additional, Salih, Hizni, additional, Várnai, Kinga A., additional, Freeman, Oliver, additional, Cripps, Sarah, additional, Phillips, Jane, additional, Collier, Jane, additional, Woods, Kerrie, additional, Channon, Keith, additional, Davies, Jim, additional, Barnes, Eleanor, additional, Jeffery, Katie, additional, and Matthews, Philippa C., additional

Published
2019
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28. Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study.

Author

Eyre DW, Lumley SF, O'Donnell D, Campbell M, Sims E, Lawson E, Warren F, James T, Cox S, Howarth A, Doherty G, Hatch SB, Kavanagh J, Chau KK, Fowler PW, Swann J, Volk D, Yang-Turner F, Stoesser N, Matthews PC, Dudareva M, Davies T, Shaw RH, Peto L, Downs LO, Vogt A, Amini A, Young BC, Drennan PG, Mentzer AJ, Skelly DT, Karpe F, Neville MJ, Andersson M, Brent AJ, Jones N, Martins Ferreira L, Christott T, Marsden BD, Hoosdally S, Cornall R, Crook DW, Stuart DI, Screaton G, Peto TE, Holthof B, O'Donnell AM, Ebner D, Conlon CP, Jeffery K, and Walker TM

Subjects
Adolescent, Adult, Age Factors, Aged, Asymptomatic Infections epidemiology, Betacoronavirus isolation & purification, COVID-19, Coronavirus Infections transmission, Coronavirus Infections virology, Female, Hospitals, Teaching statistics & numerical data, Humans, Incidence, Infectious Disease Transmission, Patient-to-Professional statistics & numerical data, Intensive Care Units statistics & numerical data, Male, Middle Aged, Pandemics, Pneumonia, Viral transmission, Pneumonia, Viral virology, Risk, SARS-CoV-2, Surveys and Questionnaires, United Kingdom epidemiology, Young Adult, Coronavirus Infections epidemiology, Health Personnel statistics & numerical data, Pneumonia, Viral epidemiology
Abstract

We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15])., Competing Interests: DE Lecture fees from Gilead, outside the submitted work, SL, DO, MC, ES, EL, FW, TJ, SC, AH, GD, SH, JK, KC, PF, JS, DV, FY, NS, PM, MD, TD, RS, LP, LD, AV, AA, BY, PD, AM, DS, FK, MN, MA, AB, NJ, LM, TC, BM, SH, RC, DC, DS, GS, TP, BH, AO, DE, CC, KJ, TW No competing interests declared, (© 2020, Eyre et al.)

Published
2020
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