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466 results on '"Downie, Laura E"'

1. List of Contributors

Author

Barnett, Melissa, primary, Brennan, Noel A., additional, Bruce, Adrian S., additional, Chantal Coles, M.-L., additional, Neil Charman, W., additional, Downie, Laura E., additional, Efron, Nathan, additional, Efron, Suzanne E., additional, Ehrmann, Klaus, additional, Fadel, Daddi, additional, Gifford, Kate, additional, Gifford, Paul, additional, Jones, Lyndon W., additional, Lawrenson, John G., additional, Lindsay, Richard G., additional, Maldonado-Codina, Carole, additional, Meyler, John, additional, Morgan, Philip B., additional, Morgan, Sarah L., additional, Ng, Alison, additional, O'Donnell, Clare, additional, Ruston, David, additional, Sankaridurg, Padmaja, additional, Schulze, Marc-Mathias, additional, Tanner, Joe, additional, Tromans, Cindy, additional, Vincent, Stephen J., additional, Walsh, Karen, additional, Wilson, Helen, additional, Wolffsohn, James S., additional, and Young, Graeme, additional

Published
2024
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8. TFOS Lifestyle: Impact of contact lenses on the ocular surface

Author

Jones, Lyndon, Efron, Nathan, Bandamwar, Kalika, Barnett, Melissa, Jacobs, Deborah S., Jalbert, Isabelle, Pult, Heiko, Rhee, Michelle K., Sheardown, Heather, Shovlin, Joseph P., Stahl, Ulli, Stanila, Adriana, Tan, Jacqueline, Tavazzi, Silvia, Ucakhan, Omur O., Willcox, Mark D.P., and Downie, Laura E.

Published
2023
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9. TFOS Lifestyle: Impact of nutrition on the ocular surface

Author

Markoulli, Maria, Ahmad, Sumayya, Arcot, Jayashree, Arita, Reiko, Benitez-del-Castillo, Jose, Caffery, Barbara, Downie, Laura E., Edwards, Katie, Flanagan, Judith, Labetoulle, Marc, Misra, Stuti L., Mrugacz, Malgorzata, Singh, Sumeer, Sheppard, John, Vehof, Jelle, Versura, Piera, Willcox, Mark D.P., Ziemanski, Jillian, and Wolffsohn, James S.

Published
2023
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15. Knowledge, views and experiences of Australian optometrists in relation to ocular stem cell therapies.

Author

Cabrera-Aguas, Maria, Downie, Laura E, Munsie, Megan M, Di Girolamo, Nick, O'Connor, Michael, and Watson, Stephanie L

Subjects
*CAREER development, *DRY eye syndromes, *STEM cell treatment, *RETINAL diseases, *REGENERATIVE medicine
Abstract

Clinical relevance: Findings from this study examining Australian optometrists' insights into ocular stem cell (SC) therapies have capacity to inform continuing professional development (CPD) about these interventions. Background: This study investigated Australian optometrists' knowledge, views, experiences, and preferred education sources regarding ocular SC therapies. Methods: An online survey was distributed to optometrists via Optometry Australia, Mivision magazine, professional groups, and social media from August 2020 to March 2021. Data were collected on demographics, and SC knowledge, awareness and experience. Results: Of 81 optometrists who completed the survey, many were metropolitan-based (85%), worked in independent practice (47%), female (56%) and >46 years of age (45%). Approximately one-fifth indicated awareness of ocular SC therapies used in standard practice; one-third had knowledge of SC clinical trials. The most noted SC therapies were for corneal disease in the United States [US] (72%) and Australia (44%). Respondents identified the availability of SC therapies for dry eye disease in Australia and the US (39% and 44% respectively), despite no regulatory-approved treatments for this indication. Clinical trials investigating inherited retinal and corneal diseases in Australia were the most commonly identified (44% and 36%, respectively). Half the respondents felt 'unsure' about the quality of evidence for treating eye conditions using SCs. One-fifth indicated concerns with these therapies; of these, most mentioned efficacy (82%), safety (76%) and/or cost (71%). About one-fifth reported being asked for advice about SCs by patients. Two-thirds felt neutral, uncomfortable, or very uncomfortable providing this advice, due to lack of knowledge or the topic being beyond their expertise. Over half (57%) were unsure if clinical management should change if patients received SC therapies. Respondents were receptive to face-to-face education. Conclusion: Some optometrists responding to this survey were aware of ocular SC therapies and/or clinical trials. CPD programs may assist with maintaining currency in this evolving field. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Systematic review and appraisal of quality, definitions and treatment recommendations of clinical guidelines for glaucoma suspects.

Author

Wu, Zhichao, Karunaratne, Senuri, Ang, Ghee Soon, Martin, Keith R., and Downie, Laura E.

Subjects
OPEN-angle glaucoma, GLAUCOMA, ANGLE-closure glaucoma, EVIDENCE gaps, TREATMENT effectiveness
Abstract

Background: To appraise the quality of clinical practice guidelines for glaucoma suspects, and to assess their consistency for how a 'glaucoma suspect' is defined and their recommendations for treatment initiation for such individuals. Methods: This study included all documents that self‐identified as a 'guideline' and provided recommendation(s) for the clinical care of glaucoma suspects. The quality of eligible guidelines was assessed using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument. Results: From 1196 records retrieved from comprehensive searches and two records manually included, 20 clinical practice guidelines were deemed eligible. Based on an appraisal using the AGREE II instrument, 16 (80%) guidelines had ≤2 domains with scores >66%. Overall, the lowest scoring domains were for applicability, editorial independence and stakeholder involvement. There was relatively poor agreement across the guidelines for what defines a 'glaucoma suspect' or 'primary open angle glaucoma [POAG] suspect', as well as the recommendations and criteria for treatment initiation in these populations. There was better agreement for the definition and recommendations for treatment initiation for 'primary angle closure suspects'. Conclusions: There is substantial room to improve the methodological quality of most current international clinical guidelines for glaucoma suspects. Clinicians should consider this finding when using such guidelines to inform their care of glaucoma suspects. Substantial variation in the definition of a POAG suspect and recommendations for treatment initiation underscores important gaps in the current evidence for the accurate prediction of glaucoma development and treatment effectiveness in these individuals. [ABSTRACT FROM AUTHOR]

Published
2024
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20. Preexisting immunity restricts mucosal antibody recognition of SARS-CoV-2 and Fc profiles during breakthrough infections

Author

Selva, Kevin J., primary, Ramanathan, Pradhipa, additional, Haycroft, Ebene R., additional, Reynaldi, Arnold, additional, Cromer, Deborah, additional, Tan, Chee Wah, additional, Wang, Lin-Fa, additional, Wines, Bruce D., additional, Hogarth, P. Mark, additional, Downie, Laura E., additional, Davis, Samantha K., additional, Purcell, Ruth A., additional, Kent, Helen E., additional, Juno, Jennifer A., additional, Wheatley, Adam K., additional, Davenport, Miles P., additional, Kent, Stephen J., additional, and Chung, Amy W., additional

Published
2023
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21. Mucosal antibody responses following Vaxzevria vaccination

Author

Selva, Kevin J, primary, Ramanathan, Pradhipa, additional, Haycroft, Ebene R, additional, Tan, Chee Wah, additional, Wang, Lin‐Fa, additional, Downie, Laura E, additional, Davis, Samantha K, additional, Purcell, Ruth A, additional, Kent, Helen E, additional, Juno, Jennifer A, additional, Wheatley, Adam K, additional, Davenport, Miles P, additional, Kent, Stephen J, additional, and Chung, Amy W, additional

Published
2023
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24. Redefining the human corneal immune compartment using dynamic intravital imaging

Author

Downie, Laura E., primary, Zhang, Xinyuan, additional, Wu, Mengliang, additional, Karunaratne, Senuri, additional, Loi, Joon Keit, additional, Senthil, Kirthana, additional, Arshad, Sana, additional, Bertram, Kirstie, additional, Cunningham, Anthony L., additional, Carnt, Nicole, additional, Mueller, Scott N., additional, and Chinnery, Holly R., additional

Published
2023
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27. TFOS DEWS II Management and Therapy Report

Author

Jones, Lyndon, Downie, Laura E., Korb, Donald, Benitez-del-Castillo, Jose M., Dana, Reza, Deng, Sophie X., Dong, Pham N., Geerling, Gerd, Hida, Richard Yudi, Liu, Yang, Seo, Kyoung Yul, Tauber, Joseph, Wakamatsu, Tais H., Xu, Jianjiang, Wolffsohn, James S., and Craig, Jennifer P.

Published
2017
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31. Contributors

Author

Anand, Vijay, primary, Atkinson, Kerry, additional, Bennett, Edward S., additional, Bergmanson, Jan P.G., additional, Bowden, Tim, additional, Cagnolati, Wolfgang, additional, Carnt, Nicole, additional, Caroline, Patrick J., additional, Cho, Pauline, additional, Clamp, John H., additional, Craig, Jennifer P., additional, Curtis, Michael, additional, Diec, Jennie, additional, Downie, Laura E., additional, Dumbleton, Kathy, additional, Eperjesi, Frank, additional, Fonn, Desmond, additional, Gilmartin, Bernard, additional, Hough, Tony, additional, Hoy, Lachlan, additional, Hui, Alex, additional, Jalbert, Isabelle, additional, Jones, Lyndon, additional, Lamb, Jaqueline, additional, Lindsay, Richard G., additional, Logan, Nicola S., additional, Mann, Aisling M., additional, McMahon, Jennifer, additional, McMonnies, Charles W., additional, Mihailidis, Michael, additional, Morris, Judith, additional, Mountford, John, additional, Newman, Stephen D., additional, Papas, Eric B., additional, Phillips, Anthony J., additional, Pullum, Kenneth W., additional, Rabbetts, Ronald, additional, Speedwell, Lynne, additional, Stapleton, Fiona, additional, Swarbrick, Helen A., additional, Sweeney, Deborah F., additional, Terry, Robert, additional, Tighe, Brian J., additional, Tromans, Cindy, additional, Vojlay, Richard, additional, Walker, Maria K., additional, Watters, Grant, additional, Williams, Lewis, additional, Wolffsohn, James S., additional, and Young, Graeme, additional

Published
2019
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35. TFOS lifestyle report executive summary:A lifestyle epidemic - Ocular surface disease

Author

Craig, Jennifer P, Alves, Monica, Wolffsohn, James S, Downie, Laura E, Efron, Nathan, Galor, Anat, Gomes, José Alvaro P, Jones, Lyndon, Markoulli, Maria, Stapleton, Fiona, Starr, Christopher E, Sullivan, Amy Gallant, Willcox, Mark D P, Sullivan, David A, Craig, Jennifer P, Alves, Monica, Wolffsohn, James S, Downie, Laura E, Efron, Nathan, Galor, Anat, Gomes, José Alvaro P, Jones, Lyndon, Markoulli, Maria, Stapleton, Fiona, Starr, Christopher E, Sullivan, Amy Gallant, Willcox, Mark D P, and Sullivan, David A

Abstract

The Tear Film & Ocular Surface Society (TFOS) Workshop entitled 'A Lifestyle Epidemic: Ocular Surface Disease' was a global initiative undertaken to establish the direct and indirect impacts of everyday lifestyle choices and challenges on ocular surface health. This article presents an executive summary of the evidence-based conclusions and recommendations of the 10-part TFOS Lifestyle Workshop report. Lifestyle factors described within the report include contact lenses, cosmetics, digital environment, elective medications and procedures, environmental conditions, lifestyle challenges, nutrition, and societal challenges. For each topic area, the current literature was summarized and appraised in a narrative-style review and the answer to a key topic-specific question was sought using systematic review methodology. The TFOS Lifestyle Workshop report was published in its entirety in the April 2023 and July 2023 issues of The Ocular Surface journal. Links to downloadable versions of the document and supplementary material, including report translations, are available on the TFOS website: http://www.TearFilm.org.

Published
2023

36. TFOS lifestyle report introduction:A lifestyle epidemic - Ocular surface disease

Author

Craig, Jennifer P, Alves, Monica, Wolffsohn, James S, Downie, Laura E, Efron, Nathan, Galor, Anat, Gomes, José Alvaro P, Jones, Lyndon, Markoulli, Maria, Stapleton, Fiona, Starr, Christopher E, Sullivan, Amy Gallant, Willcox, Mark D P, Sullivan, David A, Craig, Jennifer P, Alves, Monica, Wolffsohn, James S, Downie, Laura E, Efron, Nathan, Galor, Anat, Gomes, José Alvaro P, Jones, Lyndon, Markoulli, Maria, Stapleton, Fiona, Starr, Christopher E, Sullivan, Amy Gallant, Willcox, Mark D P, and Sullivan, David A

Published
2023

37. TFOS lifestyle:Impact of nutrition on the ocular surface

Author

Markoulli, Maria, Arcot, Jayashree, Ahmad, Sumayya, Arita, Reiko, Benitez-Del-Castillo, Jose, Caffery, Barbara, Downie, Laura E, Edwards, Katie, Flanagan, Judith, Labetoulle, Marc, Misra, Stuti, Mrugacz, Malgorzata, Singh, Sumeer, Sheppard, John, Vehof, Jelle, Versura, Piera, Willcox, Mark D P, Ziemanski, Jillian, Wolffsohn, James S, Markoulli, Maria, Arcot, Jayashree, Ahmad, Sumayya, Arita, Reiko, Benitez-Del-Castillo, Jose, Caffery, Barbara, Downie, Laura E, Edwards, Katie, Flanagan, Judith, Labetoulle, Marc, Misra, Stuti, Mrugacz, Malgorzata, Singh, Sumeer, Sheppard, John, Vehof, Jelle, Versura, Piera, Willcox, Mark D P, Ziemanski, Jillian, and Wolffsohn, James S

Abstract

Nutrients, required by human bodies to perform life-sustaining functions, are obtained from the diet. They are broadly classified into macronutrients (carbohydrates, lipids, and proteins), micronutrients (vitamins and minerals) and water. All nutrients serve as a source of energy, provide structural support to the body and/or regulate the chemical processes of the body. Food and drinks also consist of non-nutrients that may be beneficial (e.g., antioxidants) or harmful (e.g., dyes or preservatives added to processed foods) to the body and the ocular surface. There is also a complex interplay between systemic disorders and an individual's nutritional status. Changes in the gut microbiome may lead to alterations at the ocular surface. Poor nutrition may exacerbate select systemic conditions. Similarly, certain systemic conditions may affect the uptake, processing and distribution of nutrients by the body. These disorders may lead to deficiencies in micro- and macro-nutrients that are important in maintaining ocular surface health. Medications used to treat these conditions may also cause ocular surface changes. The prevalence of nutrition-related chronic diseases is climbing worldwide. This report sought to review the evidence supporting the impact of nutrition on the ocular surface, either directly or as a consequence of the chronic diseases that result. To address a key question, a systematic review investigated the effects of intentional food restriction on ocular surface health; of the 25 included studies, most investigated Ramadan fasting (56%), followed by bariatric surgery (16%), anorexia nervosa (16%), but none were judged to be of high quality, with no randomized-controlled trials.

Published
2023

40. Contributing Authors

Author

Barr, Joseph T., primary, Brennan, Noel A., additional, Bruce, Adrian S., additional, Chantal Coles, M-L., additional, Charman, W. Neil, additional, Downie, Laura E., additional, Efron, Nathan, additional, Efron, Suzanne E., additional, Ehrmann, Klaus, additional, Gifford, Paul, additional, Hirji, Nizar K., additional, Holden, Brien A., additional, Hom, Milton M., additional, Jones, Lyndon W., additional, Lawrenson, John G., additional, Lindsay, Richard G., additional, Maldonado-Codina, Carole, additional, Meyler, John, additional, Morgan, Philip B., additional, Morgan, Sarah L., additional, Ng, Alison, additional, O’Donnell, Clare, additional, Ruston, David, additional, Sankaridurg, Padmaja, additional, Schulze, Marc, additional, Srinivasan, Sruthi, additional, Szczotka-Flynn, Loretta B., additional, Tanner, Joe, additional, Tromans, Cindy, additional, Weissman, Barry A., additional, Wilson, Helen, additional, Wolffsohn, James S.W., additional, Woods, Craig A., additional, and Young, Graeme, additional

Published
2018
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42. Interventions for myopia control in children: a living systematic review and network meta-analysis

Author

Lawrenson, John G, additional, Shah, Rakhee, additional, Huntjens, Byki, additional, Downie, Laura E, additional, Virgili, Gianni, additional, Dhakal, Rohit, additional, Verkicharla, Pavan K, additional, Li, Dongfeng, additional, Mavi, Sonia, additional, Kernohan, Ashleigh, additional, Li, Tianjing, additional, and Walline, Jeffrey J, additional

Published
2023
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