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1. Impact of preoperative brachytherapy followed by radical hysterectomy in stage IB2 (FIGO 2018) cervical cancer: An analysis of SENTICOL I-II trials

Author

Uzan, C., Morice, P., Stoeckle, E., Fourchotte, V., Querleu, D., Baron, M., Ott, B., Darai, E., Leveque, J., Lanvin, D., Pomel, C., Marret, H., Leblanc, E., Houvenaeghel, G., Rouanet, P., Descamps, P., Mage, G., Graesslin, O., Baldauf, J.J., Classe, J.M., Raudrant, D., Conri, V., Douvier, S., Barranger, E., Leguevaque, P., Fouché, Y., Boulanger, L., Magaud, L., Schott, A.M., Bouttitie, F., Kissel, M., Balaya, V., Guani, B., Mathevet, P., and Lécuru, F.

Published
2023
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3. Impact of preoperative brachytherapy followed by radical hysterectomy in stage IB2 (FIGO 2018) cervical cancer: An analysis of SENTICOL I-II trials

Author

Kissel, M., primary, Balaya, V., additional, Guani, B., additional, Magaud, L., additional, Mathevet, P., additional, Lécuru, F., additional, Uzan, C., additional, Morice, P., additional, Stoeckle, E., additional, Fourchotte, V., additional, Querleu, D., additional, Baron, M., additional, Ott, B., additional, Darai, E., additional, Leveque, J., additional, Lanvin, D., additional, Pomel, C., additional, Marret, H., additional, Leblanc, E., additional, Houvenaeghel, G., additional, Rouanet, P., additional, Descamps, P., additional, Mage, G., additional, Graesslin, O., additional, Baldauf, J.J., additional, Classe, J.M., additional, Raudrant, D., additional, Conri, V., additional, Douvier, S., additional, Barranger, E., additional, Leguevaque, P., additional, Fouché, Y., additional, Boulanger, L., additional, Schott, A.M., additional, and Bouttitie, F., additional

Published
2023
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5. Sentinel lymph node biopsy and morbidity outcomes in early cervical cancer: Results of a multicentre randomised trial (SENTICOL-2)

Author

Mathevet, Patrice, primary, Lécuru, Fabrice, additional, Uzan, Catherine, additional, Boutitie, Florent, additional, Magaud, Laurent, additional, Guyon, Frederic, additional, Querleu, Denis, additional, Fourchotte, Virginie, additional, Baron, Marc, additional, Bats, Anne-Sophie, additional, Morice, P., additional, Mathevet, P., additional, Stoeckle, E., additional, Querleu, D., additional, Fourchotte, V., additional, Lécuru, F., additional, Bats, A.S., additional, Baron, M., additional, Graesslin, O., additional, Lévèque, J., additional, Ott, B., additional, Daraï, E., additional, Lanvin, D., additional, Pomel, C., additional, Marret, H., additional, Mage, G., additional, Houvenaeghel, G., additional, Baldauf, J.J., additional, Conri, V., additional, Douvier, S., additional, Delpech, Y., additional, Leblanc, E., additional, Fouché, Y., additional, Boulanger, L., additional, Descamps, P., additional, Classe, J.M., additional, Raudrant, D., additional, and Rouanet, P., additional

Published
2021
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10. A multicenter randomized trial comparing robot-assisted versus pure laparoscopic sacrocolpopexy for pelvic organ prolapse

Author

Wagner, L., primary, Douvier, S., additional, Ruffion, A., additional, Saussine, C., additional, Soustelle, L., additional, Rigaud, J., additional, Meurette, G., additional, Chartier-Kastler, E., additional, Vidart, A., additional, Manunta, A., additional, Vincens, E., additional, Dorez, M., additional, Melanie, C., additional, Hoepffner, J.L., additional, Bouvier, S., additional, Costa, P., additional, and Droupy, S., additional

Published
2019
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11. Essai randomisé, ouvert, multicentrique comparant le taux de complications de la promontofixation (PF) laparoscopique robot-assistée à la promontofixation laparoscopique classique pour le traitement des prolapsus pelviens (PP)

Author

Wagner, L., primary, Douvier, S., additional, Ruffion, A., additional, Saussine, C., additional, Soustelle, L., additional, Rigaud, J., additional, Meurette, G., additional, Phé, V., additional, Vidart, A., additional, Manunta, A., additional, Vincens, E., additional, Dorez, M., additional, Cayrac, M., additional, Hoepffner, J.L., additional, Costa, P., additional, and Droupy, S., additional

Published
2018
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22. [Cervical screening: toward a new paradigm?]

Author

Lavoué , V., Bergeron , C., Riethmuller , D., Daraï , E., Mergui , J.-L., Baldauf , J.-J., Gondry , J., Douvier , S., Lopès , P., De Reilhac , P., Quéreux , C., Letombe , B., Marchetta , J., Boulanger , J.-C., Levêque , Jean, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC)-Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), and Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC )

Subjects
Adult, Vaginal Smears, Time Factors, Adolescent, Papillomavirus Infections, Uterine Cervical Neoplasms, [SDV.CAN]Life Sciences [q-bio]/Cancer, Uterine Cervical Dysplasia, female genital diseases and pregnancy complications, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, Europe, Humans, Mass Screening, Female, France, Papillomavirus Vaccines, Papillomaviridae, Papanicolaou Test, Randomized Controlled Trials as Topic
Abstract

International audience; OBJECTIVES: Analysis of the trials which compare the virologic testing (HPV testing) and the cytology in the cervical screening. MATERIAL AND METHODS: The MedLine database was consulted using the Keywords: "cervical screening", "pap smear", "liquid based cytology", "HPV testing", "adults", "adolescents", "cervical intraepithelial neoplasia (CIN)", "uterine cervix cancer". Articles were selected according their concern about the debate of the uterine cervix cancer screening in France. RESULTS: The HPV testing seems interesting allowing a decreasing delay in the diagnosis of CIN (more diagnosis of CIN2+ in the first round and less during the second one). But, when the two rounds are added, the number of CIN2+ are identical in the two arms (cytology and HPV testing) in all the trials (except the Italian NTCC trial). A negative HPV testing protects the women much longer than cytology can do: a delay of five years between two rounds seems ideal. The HPV testing alone increases the detection rate of cervical lesions, which could regress spontaneously and may induce an overtreatment, especially in the youngest population: a triage is necessary and the cytology appears to be the best way to select the candidates for colposcopy in case of positive HPV testing and cytology. The HPV infection presents some particularities in adolescent females: for this reason, the HPV testing should not be used in this special population. In vaccinated women, a consensus for the screening is necessary. CONCLUSION: The health care providers in France have to understand the characteristics of the HPV testing: its advantages compared to the cytologic screening are only evident in case of an organization of the screening in France and even in Europe.

Published
2009

33. Un nouveau paradigme pour le dépistage du cancer du col utérin ?

Author

Lavoué, V., primary, Bergeron, C., additional, Riethmuller, D., additional, Daraï, É., additional, Mergui, J.-L., additional, Baldauf, J.-J., additional, Gondry, J., additional, Douvier, S., additional, Lopès, P., additional, de Reilhac, P., additional, Quéreux, C., additional, Letombe, B., additional, Marchetta, J., additional, Boulanger, J.-C., additional, and Levêque, J., additional

Published
2010
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34. Un stérilet migrateur…

Author

Tixier, H., primary, Mourtialon, P., additional, Combier, J.-P., additional, El Khaddari, S., additional, Douvier, S., additional, and Sagot, P., additional

Published
2009
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40. Exploration de l΄endocol.

Author

Douvier, S.

Abstract

Copyright of Traité des Infections et Pathologies Génitales À Papillomavirus is the property of Springer Nature / Books and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2007
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46. Management of cervical intra-epithelial neoplasm during pregnancy

Author

Douvier, S., Filipuzzi, L., and Sagot, P.

Subjects
*CERVICAL cancer, *CANCER in women, *CANCER patients, *PREGNANT women, *PREGNANCY complications
Abstract

Approximately 30% of women diagnosed with cervical cancer are in their childbearing years. Prenatal care provides an excellent opportunity for cervical cancer screening. The incidence of abnormal Pap smear has been reported in 5–8% of pregnant women. But we must know that Pap smears have cytologic modifications because of pregnancy. All abnormal smears have to be referred to colposcopic examination. The squamocolumnar junction is visualized in almost 100% of cases. The sensitivity of colposcopy is nearly 87% with complete concordance in 72.6%. Colposcopically directed biopsies have a good correlation with the final diagnosis with very minimal risks for both mother and fetus. The high rate of complications (hemorrhage, abortion, premature labor) and residual lesions in half of cases do not encourage conization during pregnancy. The final treatment is carried out after delivery. The only absolute indication for conization in pregnancy is to rule out microinvasive disease or make the diagnosis of invasive carcinoma when such a diagnosis will alter the timing of delivery but also when there is a no satisfactory colposcopy and a high-grade Pap smear. In these cases conization is performed for diagnostic and not therapeutic purpose. We must be aware of the high rate of loss of follow-up (6–33%). [Copyright &y& Elsevier]

Published
2003
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47. Pre-clinical study of the epinephrine–cisplatin association for the treatment of intraperitoneal carcinomatosis

Author

*, P. Favoulet, †, Magnin, G., Guilland, J. C., Beltramo, J. L., *, L. Osmak, †, *, L. Benoit, †, Rat, P., and Douvier, S.

Abstract

We have previously shown that intraperitoneal (i.p.) epinephrine enhances tumour penetration and anti-cancer activity of i.p.-administered cisplatin in rats with peritoneal carcinomatosis. Here, we show a direct correlation between the i.p. epinephrine concentration and cisplatin accumulation in rat peritoneal tumour nodules up to a concentration of 5 mg/l. This concentration leads to a maximal 3.7-fold increase of tumour platinum content and a maximal vasoconstriction of the peritoneal and tumour superficial microcirculation when registered by a laser doppler probe. Further, epinephrine half-life was 20.8±3.6 min in the peritoneal cavity of two laparotomized pigs. In these animals, epinephrine plasma concentration, heart rate and systolic blood pressure were dependent on the intraperitoneal dose of epinephrine, and life-threatening signs were not observed in either animal. In conclusion, a 5 mg/l concentration of epinephrine could be safely maintained in peritoneal fluid by regular replacement. This concentration is sufficient to maintain a constant vasoconstriction of the peritoneal and tumoral microvascular bed, and enhance the slow diffusion of cisplatin into peritoneal tumour nodules in the course of per-operative intraperitoneal chemotherapy. Copyright Harcourt Publishers Limited

Published
2001
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